CN105900991A - Fenamidone containing antibacterial composition - Google Patents
Fenamidone containing antibacterial composition Download PDFInfo
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- CN105900991A CN105900991A CN201610284881.3A CN201610284881A CN105900991A CN 105900991 A CN105900991 A CN 105900991A CN 201610284881 A CN201610284881 A CN 201610284881A CN 105900991 A CN105900991 A CN 105900991A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/34—Nitriles
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/10—Animals; Substances produced thereby or obtained therefrom
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Abstract
The invention discloses a fenamidone containing antibacterial composition. The antibacterial composition comprises an active component A and an active component B, wherein the active component A is selected from fenamidone, the active component B is arbitrarily selected from one of compounds including polyoxin, fludioxonil, bromothalonil, ethirimol or salts thereof and pyrimidine nucleotide bacteriophage, and a weight ratio of the active component A to the active component B is 1:80-60:1. The fenamidone containing antibacterial composition is high in activity on various diseases of various crops, has an evident synergistic effect and expands a bactericidal spectrum. In addition, the fenamidone containing antibacterial composition has advantages of low dosage, rain wash resistance and evident synergism.
Description
The application is divisional application, and original application is patent application " a kind of bacterium Han imidazoles of Shaanxi Meibang Pesticide Co., Ltd.
The bactericidal composition of ketone ", the Application No. 201210199879.8 of original application, original application day is 2012.6.18.
Technical field
The invention belongs to technical field of pesticide, relate to a kind of bactericidal composition containing Fenamidone in crop pest
Application.
Technical background
Fenamidone (fenamidone) molecular formula: C17H17N3OS, chemical name: (S)-1-anilino--4-methyl-2-
Methyl mercapto-4-benzylimidazoline-5-ketone, the effect machine of Fenamidone and Famoxate and methoxy acrylic bactericide
Reason is similar, suppresses line runic by stating blocks electrons transfer in former side of body level at hydrogenation olive ferment Q mono-cytochrome C radon
Breathing, imidazoles bacterium cave (s)-enantiomer specific activity (R)-enantiomer is much higher.
Antibiotic in pyrimidine nucleoside class is called: pesticide corrosion 120.The salt of ethirimol is bupirimate, it may have well kill
Bacterium activity, is widely used in agricultural.
In the real process of agricultural production, controlling disease is easiest to generate the problem that the generation of disease drug resistance.No
Compound with kind composition, be to prevent and treat the method that resistance disease is the most common.Heterogeneity compounds, according to reality application effect
Really, judge certain compounding be potentiation, add and or antagonism.In most cases, the compounding effect of pesticide all adds
And effect, really have potentiation compounding seldom, especially potentiation clearly, potentiation ratio the highest compounding the most more
Few.Study through inventor, find Fenamidone and polyoxin, CGA-173506, bromothalonil, ethirimol or its salt, pyrimidine
Ucleosides antibiotics is the most compounding, has good potentiation within the specific limits, and about Fenamidone and polyoxin, cough up
Bacterium nitrile, bromothalonil, ethirimol or its salt, the relevant of antibiotic in pyrimidine nucleoside class compound, and the most at home and abroad there is not yet relevant report
Road.
Summary of the invention
The purpose of the present invention is to propose to a kind of have that synergistic function, use cost be low, preventive effect is good containing Fenamidone
Bactericidal composition.
A kind of bactericidal composition containing Fenamidone, comprises active components A and active component B, and active components A becomes with activity
Dividing B weight ratio is 1 80～60 1, and described active components A is selected from Fenamidone, and active component B is selected from polyoxin, coughs up bacterium
Nitrile, bromothalonil, ethirimol or one of its salt, antibiotic in pyrimidine nucleoside class are planted, active components A and the weight ratio of active component B
Being 1 60～40 1, preferably Fenamidone is 1 30～20 1 with the weight ratio of polyoxin；Fenamidone and CGA-173506
Weight ratio is 1 20～20 1；Fenamidone is 1 40～10 1 with the weight ratio of bromothalonil；Fenamidone and ethirimol or its
The weight ratio of salt is 1 30～10 1；Fenamidone is 1 20～20 1 with the weight ratio of antibiotic in pyrimidine nucleoside class, most preferably
Weight ratio for Fenamidone Yu polyoxin is 1 15～10 1；Fenamidone is 1 10～10 with the weight ratio of CGA-173506
1；Fenamidone is 1 20～5 1 with the weight ratio of bromothalonil；The weight ratio of Fenamidone and ethirimol or its salt be 1 15～
51；Fenamidone is 1 10～10 1 with the weight ratio of antibiotic in pyrimidine nucleoside class.
The described bactericidal composition containing Fenamidone is for preventing and treating the disease of crops, and described crops include grain
Crop, legume crop, oil crop, fibre crops, sugar crop, melon crop, fruits crop, dry fruit crop, hobby
Crop, root crop, flower crop, medicinal crop, crop, green manure pasture crop.
The described bactericidal composition containing Fenamidone is for preventing and treating the disease of crops, and described disease includes downy mildew
Disease, late blight, peronospora tabacina, early blight, spot defoliation, gray mold, melasma, damping off, powdery mildew, droop, red star
Disease, leaf mold, graywall, root rot, damping-off, bakanae disease, sclerotiniose, bunt, anthrax, ring spot, rust, black star
Sick.
In the present composition, the content of active component depends on amount of application when being used alone, and also depends on a kind of chemical combination
The mixed ratio of thing and another kind of compound and potentiation degree, also the most relevant with target disease.Generally in compositions
The weight percentage of active component is the 2%～90% of gross weight, is preferably 5%～80%.According to different preparation classes
Type, active component content scope is different.Generally, liquid preparation contains the active substance of by weight 1%～60%, preferably
Ground is 5%～50%；Solid preparation contains the active substance of by weight 5%～80%, preferably 10%～80%.
At least containing a kind of surfactant in the bactericidal composition of the present invention, when being beneficial to use, active component is in water
Dispersion.Surface-active contents is the 2%～30% of total formulation weight amount, and surplus is solid or liquid diluent.
Surfactant selected by the bactericidal composition of the present invention is known in those skilled in the art: can be selected from
One or more in dispersant, wetting agent, thickening agent or defoamer.According to different dosage form, preparation can also contain this area
Stabilizer well known to technical staff, antifreeze etc..
The bactericidal composition of the present invention through dilution or directly can be used before use by user.Its preparation can be by ability
Prepared by the processing method well known to field technique personnel, will add after active component mixes with liquid flux or solid carrier
One or more in surfactant such as dispersant, stabilizer, wetting agent, binding agent, defoamer etc..
The bactericidal composition of the present invention, can be processed into acceptable dosage form on any pesticide, wherein preferably agent on demand
Type is wettable powder, water dispersible granules, suspending agent, suspension emulsion, microemulsion, aqueous emulsion, microcapsule suspending agent, microcapsule suspension-outstanding
Floating agent, it is possible to make water preparation, soluble liquid, soluble powder.
Compositions comprises following constituent content when making wettable powder: active components A 0.1%～60%, active component
B0.1%～80%, dispersant 2%～10%, wetting agent 2%～10%, filler surplus.
Compositions includes following constituent content when making water dispersible granules: active components A 0.1%～60%, active component B
0.1%～80%, dispersant 3%～12%, wetting agent 1%～8%, disintegrating agent 1%～10%, binding agent 0～4%, filler
Surplus.
Compositions includes following constituent content when making suspending agent: active components A 0.1%～50%, active component B
0.1%～50%, dispersant 2%～10%, wetting agent 2%～10%, defoamer 0.01%～2%, thickening agent 0%～2%,
Antifreeze 0～8%, deionized water add to 100%.
Compositions includes following constituent content when making suspension emulsion: active components A 0.1%～50%, active component B
0.1%～50%, dispersant 2%～10%, defoamer 0.01%～2%, solvent 1%～15%, thickening agent 0%～2%, breast
Agent 2%～12%, antifreeze 0～8%, deionized water add to 100%.
Compositions comprises following constituent content when making aqueous emulsion: active components A 0.1%～50%, active component B
0.1%～50%, solvent 1%～30%, emulsifying agent 1%～15%, antifreeze 0～8%, thickening agent 0%～2%, defoamer
0.01%～2%, deionized water supplies surplus.
Compositions comprises following constituent content when making microemulsion: active components A 0.1%～50%, active component B
0.1%～50%, solvent 0～30%, emulsifying agent 3%～20%, antifreeze 0～8%, defoamer 0.01%～2%, stabilizer
0～4%, deionized water supplies surplus.
Compositions includes following constituent content when making microcapsule suspending agent: active components A 0.1%～50%, active component B
0.1%～50%, macromolecule cyst material 2%～10%, dispersant 1%～10%, solvent 1%～10%, defoamer
0.01%～2%, emulsifying agent 1%～7%, pH adjusting agent 0.01%～5%, deionized water add to 100%.
Compositions includes following constituent content when making microcapsule suspension-suspendinagent agent: active components A 0.1%～50%, activity
Composition B 0.1%～50%, macromolecule cyst material 2%～12%, dispersant 1%～12%, wetting agent 1%～8%, solvent
1%～15%, emulsifying agent 1%～6%, defoamer 0.01%～2%, thickening agent 0.05%～2%, pH adjusting agent 0.01%～
5%, deionized water adds to 100%.
The wettable powder the key technical indexes of the present invention:
The water dispersible granules the key technical indexes of the present invention:
The suspending agent the key technical indexes of the present invention:
The aqueous emulsion the key technical indexes of the present invention:
The microemulsion the key technical indexes of the present invention:
The microcapsule suspending agent the key technical indexes of the present invention:
The microcapsule suspension-suspendinagent agent the key technical indexes of the present invention:
The suspension emulsion the key technical indexes of the present invention:
It is an advantage of the current invention that:
(1) present composition has good potentiation and lasting effect within the specific limits, and preventive effect is higher than single dose；(2) agriculture
Medicinal dose reduces, and reduces pesticide residual quantity on crop, alleviates environmental pollution；(3) fungicidal spectrum is expanded, to multiple diseases
Such as downy mildew, late blight, peronospora tabacina, early blight, spot defoliation, gray mold, melasma, damping off, powdery mildew, wither
Disease, rust, leaf mold, graywall, root rot, damping-off, bakanae disease, sclerotiniose, bunt, anthrax, ring spot, rust
Sick, scab has greater activity.
Detailed description of the invention
Below in conjunction with embodiment, further instruction of the present invention, the percentage ratio in embodiment are all weight percentage, but
The invention is not limited in this.
Application Example one
Example 1～16 wettable powder
By Fenamidone, effective ingredient B, dispersant, wetting agent, filler mixing, mix homogeneously in mixed cylinder, through air-flow
Pulverizer remixes uniformly after pulverizing, and i.e. can be made into wettable powder product of the present invention.Specifically it is shown in Table 1.
Table 1 example 1～16 each component and content
Example 17～31 water dispersible granules
By Fenamidone, effective ingredient B, dispersant, wetting agent, binding agent (can add and can be not added with), disintegrating agent, filler together
Obtain the particle diameter needed through comminution by gas stream, obtain granulation materials.System is passed through in item is quantitatively sent into fluidized bed granulating dryer
Grain and dried, prepares water dispersible granules product of the present invention.Specifically it is shown in Table 2.
Table 2 example 17～31 each component and content
Example 32～47 suspending agent
By dispersant, wetting agent, defoamer, thickening agent (can add and can be not added with), antifreeze (can add and can be not added with) through at a high speed
Shear-mixed is uniform, adds Fenamidone, effective ingredient B, and surplus deionized water is supplied, and in ball mill, ball milling 2～3 is little
Time, make diameter of particle all below 5 μm, prepare oil-suspending agent product of the present invention.Specifically it is shown in Table 3.
Table 3 example 32～47 each component and content
By antibacterial to active component B polyoxin, CGA-173506, bromothalonil, ethirimol or its salt in table 1～3, pyridimine nucleosides
Element exchanges, and can prepare novel formulation.
48～50 suspension emulsions
By dispersant in above-mentioned formulation material, defoamer, thickening agent (can add and can be not added with), antifreeze (can add and can be not added with), steady
Determining agent (can add and can be not added with), solvent through high speed shear mix homogeneously, add Fenamidone, in ball mill, ball milling 2～3 is little
Time, make diameter of particle all below 5 μm, prepare Fenamidone suspending agent, then by active component B, emulsifying agent and various help
The direct emulsifying of agent high speed agitator, in suspending agent, prepares suspension emulsion product of the present invention.Specifically it is shown in Table 4.
Table 4 example 48～50 each component and content
By active component B CGA-173506, bromothalonil, ethirimol or its salt interchange in table 4, novel formulation can be prepared.
Example 51～60 aqueous emulsion
Fenamidone, effective ingredient B, solvent, emulsifying agent are added together, make to be dissolved into homogeneous oil phase；By deionized water,
Antifreeze (can add and can be not added with), thickening agent (can add and can be not added with), defoamer mix, and become homogeneous aqueous phase.In high-speed stirred
Under, aqueous phase is added oil phase, prepares aqueous emulsion product of the present invention.Specifically it is shown in Table 5.
Table 5 example 51～60 each component and content
By active component B polyoxin, CGA-173506, bromothalonil, ethirimol or its salt, antibiotic in pyrimidine nucleoside class in table 5
Exchange, novel formulation can be prepared.
Example 61～64 microcapsule suspending agent
By Fenamidone, active component B, macromolecule cyst material, solvent mixing, make to be dissolved into homogeneous oil phase, shearing
Under the conditions of, oil phase is joined containing emulsifying agent, pH adjusting agent, dispersant, defoamer aqueous phase solution in, surplus deionization
Water is supplied, and bi-material reacts at oil-water interfaces, forms macromolecule cyst wall, makes the present composition finely disseminated micro-
Capsule suspending agent product.Specifically it is shown in Table 6.
Table 6 example 61～64 each component and content
Example 65,66 microcapsule suspension-suspendinagent agent
By active component B, macromolecule cyst material, solvent mixing, make to be dissolved into homogeneous oil phase, by oil phase at shearing condition
Under join containing emulsifying agent, pH adjusting agent aqueous phase solution in, make finely disseminated microcapsule suspending agent.By dispersant, wet
Profit agent, defoamer, thickening agent (can add and can be not added with), through high speed shear mix homogeneously, add Fenamidone, ball in ball mill
Grind 2～3 hours, make diameter of particle all below 5 μm, prepare suspending agent, then suspending agent is joined micro-capsule suspension
Aqueous phase solution in, deionized water supplies surplus, makes the present composition finely disseminated microcapsule suspension-suspendinagent agent product.
Specifically it is shown in Table 7.
Table 7 example 65,66 each component and content
The embodiment of the present invention is the method using Toxicity Determination and field test to combine.First pass through indoor virulence to survey
Fixed, after clear and definite two kinds of medicaments are compounding by a certain percentage potentiation ratio (SR), SR ＜ 0.5 is antagonism, 0.5≤SR≤1.5
For summation action, SR ＞ 1.5 is potentiation, on this basis, then carries out field test.
Test method: after prerun determines each medicament effective inhibition concentration scope, medicament is set 5 respectively by active constituent content
Individual dosage processes, if clear water comparison.Carry out with reference to " farm-chemical indoor determination test rule antibacterial ", use mycelial growth speed
Rate method measures the medicament virulence to crop pathogenic bacteria.Measure colony diameter by decussation method after 72h, calculate each process and only grow
Amount, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) is converted into logarithm value (x), with minimum
Square law tries to achieve virulence regression equation (y=a+bx), and thus calculates the EC of every kind of medicament50Value.Simultaneously according to Wadley method
Calculating two medicaments different ratio synergy ratio (SR), SR ＜ 0.5 is antagonism, and 0.5≤SR≤1.5 are summation action,
SR ＞ 1.5 is potentiation.Computing formula is as follows:
Wherein: a, b are respectively the ratio that active components A is shared in combination with active component B；
A is Fenamidone；
B choosing is planted to polyoxin, CGA-173506, bromothalonil, ethirimol or one of its salt, antibiotic in pyrimidine nucleoside class.
Application Example two:
For examination disease: cucumber downy mildew.
Test medicine is provided by Shaanxi Meibang Pesticide Co., Ltd..
EXPERIMENTAL DESIGN: determine having of the former medicine of Fenamidone and polyoxin and the two different ratio mixture through pilot study
Effect inhibition concentration scope.
Toxicity test result
Table 8 Fenamidone toxicity test analysis of results table to cucumber downy mildew compounding with polyoxin
As shown in Table 8, Fenamidone and polyoxin to the proportioning of cucumber downy mildew when 1:80～60:1, potentiation ratio
SR is all higher than 1.7, illustrates that both all show potentiation at mixture in the range of 1:80～60:1, when Fenamidone and many anti-mildews
Element proportioning when 1:30～20:1, potentiation is the most prominent, potentiation ratio all more than 2.05, wherein when Fenamidone with
When polyoxin weight ratio is 2:3, potentiation ratio is maximum, and potentiation is the most obvious.Through applicant test discovery Fenamidone with
The proportioning of polyoxin is 20:1,15:1,10:1,9:1,8:1,7:1,6:1,5:1,4:1,3:1,2:1,1:1,1:2,1:3,1:
4, when 1:5,1:6,1:7,1:8,1:9,1:10,1:15,1:20,1:25,1:30, Fenamidone is compounding with polyoxin to downy mildew
Disease, late blight, peronospora tabacina, early blight, spot defoliation, gray mold, melasma, damping off, powdery mildew, droop, red star
Disease, leaf mold, graywall, root rot, damping-off, bakanae disease, sclerotiniose, bunt, anthrax, ring spot, rust, black star
Sick preventing and treating has obvious potentiation, and potentiation ratio is all more than 1.50.
Application Example three:
For examination disease: grape grey mould.
Test medicine is provided by Shaanxi Meibang Pesticide Co., Ltd..
EXPERIMENTAL DESIGN: determine the effective of the former medicine of Fenamidone and CGA-173506 and the two different ratio mixture through pilot study
Inhibition concentration scope.
Toxicity test result
Table 9 Fenamidone toxicity test analysis of results table to grape grey mould compounding with CGA-173506
As shown in Table 9, Fenamidone and CGA-173506 proportioning are equal to grape grey mould potentiation ratio SR when 1:80～60:1
More than 1.5, illustrate that both all show potentiation at mixture in the range of 1:80～60:1, when joining of Fenamidone and CGA-173506
Ratio is when 1:20～20:1, and potentiation is the most prominent, and potentiation ratio is all more than 2.00.Wherein when Fenamidone and CGA-173506
When weight ratio is 1:1, potentiation ratio is maximum, and potentiation is the most obvious, tests finding Fenamidone and CGA-173506 through applicant
Proportioning is 20:1,15:1,10:1,9:1,8:1,7:1,6:1,5:1,4:1,3:1,2:1,1:1,2:3,1:2,1:3,1:4,1:5,
When 1:6,1:7,1:8,1:9,1:10,1:15,1:20, Fenamidone is compounding with CGA-173506 to downy mildew, late blight, frost phytophthora
Disease, early blight, spot defoliation, gray mold, melasma, damping off, powdery mildew, droop, rust, leaf mold, graywall,
Root rot, damping-off, bakanae disease, sclerotiniose, bunt, anthrax, ring spot, rust, the preventing and treating of scab have substantially
Potentiation, potentiation ratio is all more than 1.50.
Application Example four:
For examination disease: apple anthracnose.
Test medicine is provided by Shaanxi Meibang Pesticide Co., Ltd..
EXPERIMENTAL DESIGN: determine the effective of the former medicine of Fenamidone and bromothalonil and the two different ratio mixture through pilot study
Inhibition concentration scope.
Toxicity test result
Table 10 Fenamidone and the bromothalonil compounded toxicity test analysis of results table to apple anthracnose
As shown in Table 10, Fenamidone and bromothalonil to the proportioning of apple anthracnose when 1:80～60:1, potentiation ratio
SR is all higher than 1.5, illustrates that both all show potentiation, when Fenamidone and bromothalonil at mixture in the range of 1:80～60:1
Proportioning when 1:40～10:1, potentiation is the most prominent, and potentiation ratio is all more than 2.20, wherein when Fenamidone and bromine
When bacterium nitrile weight ratio is 1:4, potentiation ratio is maximum, and potentiation is the most obvious.Discovery Fenamidone and bromine bacterium is tested through applicant
The proportioning of nitrile is 10:1,9:1,8:1,7:1,6:1,5:1,4:1,3:1,2:1,1:1,1:5,1:6,1:7,1:8,1:9,1:10,
When 1:11,1:12,1:13,1:14,1:15,1:16,1:17,1:18,1:19,1:20,1:25,1:30,1:35,1:40, imidazoles
Bacterium ketone and bromothalonil compounded to downy mildew, late blight, peronospora tabacina, early blight, spot defoliation, gray mold, melasma, damping off
Disease, powdery mildew, droop, rust, leaf mold, graywall, root rot, damping-off, bakanae disease, sclerotiniose, bunt, charcoal
Cellulitis disease, ring spot, rust, the preventing and treating of scab have obvious potentiation, and potentiation ratio is all more than 1.50.
Application Example five:
For examination disease: powdery mildew of strawberry.
Test medicine is provided by Shaanxi Meibang Pesticide Co., Ltd..
EXPERIMENTAL DESIGN: determine Fenamidone and ethirimol or the former medicine of its salt and the two different ratio mixture through pilot study
Effective inhibition concentration scope.
Toxicity test result
Table 11 Fenamidone toxicity test analysis of results table to powdery mildew of strawberry compounding with ethirimol or its salt
As shown in Table 11, the proportioning of powdery mildew of strawberry when 1:80～60:1, is increased by Fenamidone and ethirimol or its salt
Effect ratio SR is all higher than 1.5, illustrate that both all show potentiation at mixture in the range of 1:80～60:1, when Fenamidone and
The proportioning of ethirimol or its salt is when 1:30～10:1, and potentiation is the most prominent, and potentiation ratio is all more than 2.20.Wherein when
When Fenamidone is 1:3 with ethirimol or its salt weight ratio, potentiation ratio is maximum, and potentiation is the most obvious.Test through applicant
The proportioning finding Fenamidone and ethirimol or its salt is 10:1,9:1,8:1,7:1,6:1,5:1,4:1,3:1,2:1,1:1,1:
2, when 1:3,1:4,1:5,1:6,1:7,1:8,1:9,1:10,1:15,1:20,1:25,1:30, Fenamidone and ethirimol or its
Salt compounding to downy mildew, late blight, peronospora tabacina, early blight, spot defoliation, gray mold, melasma, damping off, powdery mildew,
Droop, rust, leaf mold, graywall, root rot, damping-off, bakanae disease, sclerotiniose, bunt, anthrax, wheel stricture of vagina
Disease, rust, the preventing and treating of scab have obvious potentiation, and potentiation ratio is all more than 1.50.
Application Example six:
For examination disease: tomato blight.
Test medicine is provided by Shaanxi Meibang Pesticide Co., Ltd..
EXPERIMENTAL DESIGN: determine Fenamidone and the former medicine of antibiotic in pyrimidine nucleoside class and the two different ratio through pilot study
Effective inhibition concentration scope of mixture.
Toxicity test result
Table 12 Fenamidone toxicity test analysis of results table to tomato blight compounding with antibiotic in pyrimidine nucleoside class
As shown in Table 12, Fenamidone and antibiotic in pyrimidine nucleoside class to the proportioning of tomato blight when 1:80～60:1,
Potentiation ratio SR is all higher than 1.5, illustrates that both all show potentiation at mixture in the range of 1:80～60:1, works as Fenamidone
With the proportioning of antibiotic in pyrimidine nucleoside class when 1:20～20:1, potentiation is the most prominent, and potentiation ratio is all more than 2.10.
Wherein when Fenamidone and antibiotic in pyrimidine nucleoside class weight ratio are 1:1, potentiation ratio is maximum, and potentiation is the most obvious.Warp
Applicant test find the proportioning of Fenamidone and antibiotic in pyrimidine nucleoside class be 20:1,15:1,10:1,9:1,8:1,7:1,6:
1, when 5:1,4:1,3:1,2:1,1:1,1:2,1:3,1:4,1:5,1:6,1:7,1:8,1:9,1:10,1:15,1:20, imidazoles bacterium
Ketone and polyoxin compound downy mildew, late blight, peronospora tabacina, early blight, spot defoliation, gray mold, melasma, damping off
Disease, powdery mildew, droop, rust, leaf mold, graywall, root rot, damping-off, bakanae disease, sclerotiniose, bunt, charcoal
Cellulitis disease, ring spot, rust, the preventing and treating of scab have obvious potentiation, and potentiation ratio is all more than 1.50.
Test of pesticide effectiveness part:
Test medicine is researched and developed by Shaanxi Meibang Pesticide Co., Ltd., is provided, comparison medicament 20% Fenamidone suspending agent (from
Join), 3% Wettable polyoxin powder (commercial), 50% CGA-173506 wettable powder (commercial), 25% bromothalonil wettable powder
Agent (commercial), 25% ethirimol suspending agent (autogamy), 4% antibiotic in pyrimidine nucleoside class water preparation (commercial).
Application Example seven Fenamidone and active component B and the compounding preventing and treating cucumber downy mildew test of pesticide effectiveness thereof
This test arrangement, in Weinan city Linwei district, Shaanxi Province, investigates the cucumber downy mildew state of an illness, in the state of an illness initial stage first before medicine
Secondary dispenser, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days, 30 days for the second time, investigate disease index respectively and count
Calculate preventive effect.Experimental result is as follows:
Table 13 Fenamidone and active component B and the compounding preventing and treating cucumber downy mildew test of pesticide effectiveness thereof
As can be seen from Table 13, cucumber downy mildew, prevention effect can effectively be prevented and treated after Fenamidone is compounding with active component B
It is superior to the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example eight Fenamidone and active component B and compounding prevent and treat the late blight of potato test of pesticide effectiveness
This test arrangement, in Weinan City suburb, Shaanxi Province, investigates the late blight of potato state of an illness, in the state of an illness initial stage first before medicine
Secondary dispenser, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days, 30 days for the second time, investigate disease index respectively and count
Calculate preventive effect.Experimental result is as follows:
Table 14 Fenamidone and active component B and compounding prevent and treat the late blight of potato test of pesticide effectiveness
As can be seen from Table 14, the late blight of potato, preventing and treating effect can effectively be prevented and treated after Fenamidone is compounding with active component B
Fruit is superior to the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example nine Fenamidone and active component B and the compounding preventing and treating peronophythora litchi test of pesticide effectiveness thereof
This test arrangement, in suburb, Dongguan City, Guangdong Province, investigates the peronophythora litchi state of an illness, in the state of an illness initial stage first before medicine
Secondary dispenser, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days, 30 days for the second time, investigate disease index respectively and count
Calculate preventive effect.Experimental result is as follows:
Table 15 Fenamidone and active component B and the compounding preventing and treating peronophythora litchi test of pesticide effectiveness thereof
As can be seen from Table 15, peronophythora litchi, preventing and treating effect can effectively be prevented and treated after Fenamidone is compounding with active component B
Fruit is superior to the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example ten Fenamidone and active component B and the compounding preventing and treating wheat powdery mildew test of pesticide effectiveness thereof
This test arrangement, at Shaanxi Province's Hanzhong City, investigates the wheat powdery mildew state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage,
Dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days, 30 days for the second time, investigate disease index respectively and calculate preventive effect.
Experimental result is as follows:
Table 16 Fenamidone and active component B and the compounding preventing and treating wheat powdery mildew test of pesticide effectiveness thereof
As can be seen from Table 16, wheat powdery mildew, prevention effect can effectively be prevented and treated after Fenamidone is compounding with active component B
It is superior to the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example 11 Fenamidone and active component B and the compounding preventing and treating graw mold of tomato test of pesticide effectiveness thereof
This test arrangement, in Jingyang County, Shaanxi Province, investigates the graw mold of tomato state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage,
Dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days, 30 days for the second time, investigate disease index respectively and calculate preventive effect.
Experimental result is as follows:
Table 17 Fenamidone and active component B and the compounding preventing and treating graw mold of tomato test of pesticide effectiveness thereof
As can be seen from Table 17, graw mold of tomato, prevention effect can effectively be prevented and treated after Fenamidone is compounding with active component B
It is superior to the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example ten diimidazole bacterium ketone and active component B and the compounding preventing and treating apple anthracnose test of pesticide effectiveness thereof
This test arrangement, in Weinan City Pucheng County, Shaanxi Province, investigates the apple anthracnose state of an illness, in the state of an illness initial stage first before medicine
Secondary dispenser, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days, 30 days for the second time, investigate disease index respectively and count
Calculate preventive effect.Experimental result is as follows:
Table 18 Fenamidone and active component B and the compounding preventing and treating apple anthracnose test of pesticide effectiveness thereof
As can be seen from Table 18, apple anthracnose, prevention effect can effectively be prevented and treated after Fenamidone is compounding with active component B
It is superior to the preventive effect of single dose, and the preventive effect phase is long, and alternaria leaf spot of apple, ring spot can be treated, prevention effect after 14 days
Up to more than 97%.In test scope of medication, target crop is had no adverse effects.
After draw through tests different local throughout the country, Fenamidone and polyoxin, CGA-173506, bromothalonil,
To the downy mildew in various crop, late blight, peronospora tabacina, early epidemic after ethirimol or its salt, antibiotic in pyrimidine nucleoside class are compounding
Disease, spot defoliation, gray mold, melasma, damping off, powdery mildew, droop, rust, leaf mold, graywall, root rot,
The preventive effect of the Common Diseases such as damping-off, bakanae disease, sclerotiniose, bunt, anthrax, ring spot, rust, scab all exists
More than 95%, it is better than single dose preventive effect, potentiation is obvious.
Claims (8)
1. the bactericidal composition containing Fenamidone, it is characterised in that containing active components A and active component B, active components A
Being 1 80～60 1 with active component B weight ratio, described active components A is selected from Fenamidone, and active component B is selected from bromine bacterium
Nitrile, ethirimol or one of its salt, antibiotic in pyrimidine nucleoside class are planted.
Bactericidal composition containing Fenamidone the most according to claim 1, it is characterised in that: active components A becomes with activity
The weight ratio dividing B is 1 60～40 1.
Bactericidal composition containing Fenamidone the most according to claim 2, it is characterised in that: Fenamidone and bromothalonil
Weight ratio is 1 40～10 1.
Bactericidal composition containing Fenamidone the most according to claim 2, it is characterised in that: Fenamidone and ethirimol or
The weight ratio of its salt is 1 30～10 1.
Bactericidal composition containing Fenamidone the most according to claim 2, it is characterised in that: Fenamidone and pyrimidine nucleoside
The weight ratio of antibiotics is 1 20～20 1.
6. the bactericidal composition of Fenamidone is contained according to any one described in claim 3 to 5, it is characterised in that: compositions system
Become wettable powder, water dispersible granules, suspending agent, suspension emulsion, microemulsion, aqueous emulsion, microcapsule suspending agent, microcapsule suspension-suspension
Agent.
Bactericidal composition containing Fenamidone the most according to claim 6, for preventing and treating the application of crop pest.
Application the most according to claim 7, it is characterised in that: described disease includes downy mildew, late blight, frost phytophthora
Disease, early blight, spot defoliation, gray mold, melasma, damping off, powdery mildew, droop, rust, leaf mold, graywall,
Root rot, damping-off, bakanae disease, sclerotiniose, bunt, anthrax, ring spot, rust, scab.
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| CN201610284881.3A CN105900991A (en) | 2012-06-18 | 2012-06-18 | Fenamidone containing antibacterial composition |
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| CN201210199879.8A CN103503894B (en) | 2012-06-18 | 2012-06-18 | A kind of bactericidal composition containing Fenamidone |
| CN201610284881.3A CN105900991A (en) | 2012-06-18 | 2012-06-18 | Fenamidone containing antibacterial composition |
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| CN104186550A (en) * | 2014-09-22 | 2014-12-10 | 江苏省绿盾植保农药实验有限公司 | Sterilizing composition containing pyrimidine nucleoside antibiotics and eugenol and application thereof |
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| CN101697722A (en) * | 2009-10-29 | 2010-04-28 | 深圳诺普信农化股份有限公司 | Famoxadone-containing bactericidal composition |
| EP2329713A1 (en) * | 2008-08-18 | 2011-06-08 | Mitsui Chemicals Agro, Inc. | Plant disease control agent comprising d-tagatose as active ingredient, and plant disease control method |
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2012
- 2012-06-18 CN CN201610284881.3A patent/CN105900991A/en active Pending
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| CN1153454A (en) * | 1994-07-22 | 1997-07-02 | 罗纳-普朗克农业化学公司 | Fungicidal composition including 2-imidazoline-5-one |
| CN1245396A (en) * | 1997-12-02 | 2000-02-23 | 罗纳-普朗克农业化学公司 | Fungicide composition containing 2-imidazoline-5-one |
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| EP2329713A1 (en) * | 2008-08-18 | 2011-06-08 | Mitsui Chemicals Agro, Inc. | Plant disease control agent comprising d-tagatose as active ingredient, and plant disease control method |
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| CN103503894A (en) | 2014-01-15 |
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