CN104412982A - Compound efficient antibacterial composition containing fluoride ether bacteria amide - Google Patents
Compound efficient antibacterial composition containing fluoride ether bacteria amide Download PDFInfo
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- CN104412982A CN104412982A CN201310403776.3A CN201310403776A CN104412982A CN 104412982 A CN104412982 A CN 104412982A CN 201310403776 A CN201310403776 A CN 201310403776A CN 104412982 A CN104412982 A CN 104412982A
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Abstract
The invention discloses a compound efficient antibacterial composition containing fluoride ether bacteria amide. The composition is prepared from an active ingredient A and an active ingredient B, wherein the active ingredient A is fluoride ether bacteria amide, and the active ingredient B is any one selected from metalaxyl, metalaxyl-M, mandipropamid, fluazinam, boscalid, zoxamide, fluopicolide and flutolanil; and the weight ratio of the active ingredient A to the active ingredient B is 1:80 to 80:1. The composition has a synergetic effect on multiple diseases harmful to agricultural production, so that usage of pesticide can be reduced, residual amount of pesticide on crops can be reduced, and environmental pollution can be reduced. The composition is safe to humans and livestock and is good in environmental compatibility, and drug resistance is unlikely to produce against diseases.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of application of compound highly effective bactericidal composition on corps diseases of fluorine-containing ether bacterium acid amides.
Background technology
Fluorine ether bacterium acid amides is a kind of amide-type wide-spectrum bactericide; very high biologically active is had to Oomycete fungal germ; there is protection and therapeutic action preferably; fluorine phonetic bacterium acid amides has stronger interior absorption; absorb by cauline leaf; conducted by plant lower to upper part direction, distribute to whole strain crop along plant xylem.Metalaxyl, Metalaxyl-M, mandipropamid, fluazinam, Boscalid, zoxamide, fluopicolide, flutolanil all belong to common fungicide, are widely used in the disease of crops.
But in the real process of agricultural production, the problem that controlling disease the most easily produces is the generation of disease drug resistance.Different cultivars composition carries out composite, is to prevent and treat the very common method of resistance disease.Heterogeneity is carried out composite, according to practical application effect, judge certain composite be synergy, add and or antagonism.In most cases, the composite effect of sterilization is all additive effect, really has the seldom composite of synergistic effect, especially synergistic effect clearly, very high composite just less of synergy ratio.Study through inventor, find fluorine ether bacterium acid amides and metalaxyl, Metalaxyl-M, mandipropamid, fluazinam, Boscalid, zoxamide, fluopicolide, flutolanil is composite after can produce good synergistic effect, and not yet open about the relevant report that fluorine ether bacterium acid amides and metalaxyl, Metalaxyl-M, mandipropamid, fluazinam, Boscalid, zoxamide, fluopicolide, flutolanil are composite.
Summary of the invention
The object of the invention is to propose a kind of to there is synergistic function, the compound highly effective bactericidal composition of use cost is low, preventive effect is good fluorine-containing ether bacterium acid amides.
The compound highly effective bactericidal composition of the fluorine-containing ether bacterium acid amides that the present invention proposes contains active components A and active component B, activity is divided into A and active component B weight ratio is 1:80 ~ 80:1, described active components A is selected from fluorine ether bacterium acid amides, active component B is selected from the one in metalaxyl, Metalaxyl-M, mandipropamid, fluazinam, Boscalid, zoxamide, fluopicolide, flutolanil, and active components A and the preferred weight ratio of active component B are 1:40 ~ 40:1, the weight ratio being more preferably fluorine ether bacterium acid amides and metalaxyl is 15:1 ~ 1:25, the weight ratio of fluorine ether bacterium acid amides and Metalaxyl-M is 20:1 ~ 1:20, the weight ratio of fluorine ether bacterium acid amides and mandipropamid is 20:1 ~ 1:20, the weight ratio of fluorine ether bacterium acid amides and fluazinam is 20:1 ~ 1:20, the weight ratio of fluorine ether bacterium acid amides and Boscalid is 20:1 ~ 1:20, the weight ratio of fluorine ether bacterium acid amides and zoxamide is 20:1 ~ 1:20, the weight ratio of fluorine ether bacterium acid amides and fluopicolide is 20:1 ~ 1:20, the weight ratio of fluorine ether bacterium acid amides and flutolanil is 15:1 ~ 1:25, the weight ratio most preferably being fluorine ether bacterium acid amides and metalaxyl is 4:1 ~ 1:14, the weight ratio of fluorine ether bacterium acid amides and Metalaxyl-M is 9:1 ~ 1:9, the weight ratio of fluorine ether bacterium acid amides and mandipropamid is 9:1 ~ 1:9, the weight ratio of fluorine ether bacterium acid amides and fluazinam is 9:1 ~ 1:9, the weight ratio of fluorine ether bacterium acid amides and Boscalid is 9:1 ~ 1:9, the weight ratio of fluorine ether bacterium acid amides and zoxamide is 9:1 ~ 1:9, the weight ratio of fluorine ether bacterium acid amides and fluopicolide is 9:1 ~ 1:9, and the weight ratio of fluorine ether bacterium acid amides and flutolanil is 4:1 ~ 1:9.
The compound highly effective bactericidal composition of the fluorine-containing ether bacterium acid amides that the present invention proposes is for preventing and treating the purposes of disease on crops, and described crops comprise cereal crops, legume crop, fiber crop, sugar [yielding, melon crop, fruits crop, dry fruit crop, hobby crop, root crop, oil crop, flower crop, medicinal crop, crop, green manure pasture crop; Described disease comprises downy mildew, epidemic disease, rust, balck shank, foot rot, powdery mildew, root rot, damping off, seedling rot, club root, gray mold, dish stalk mould, brown spot, rice blast or banded sclerotial blight.
The weight ratio of active components A, active component B is 1:80 ~ 80:1.In usual composition, the weight percentage of active component is 0.5% ~ 90% of gross weight, is preferably 5% ~ 80%.According to different preparation types, active component content scope is different.Usually, liquid preparation contains the active substance of by weight 1% ~ 70%, is preferably 5% ~ 50%; Solid pharmaceutical preparation contains the active substance of by weight 5% ~ 80%, is preferably 10% ~ 80%.
At least containing a kind of surfactant in bactericidal composition of the present invention, the dispersion of active component in water when being beneficial to use.Surface-active contents is 5% ~ 30% of total formulation weight amount, and surplus is solid or liquid diluent.
Bactericidal composition of the present invention can by user before use through diluting or directly using.Its preparation can be prepared by common processing method known in those skilled in the art, after mixing with liquid flux or solid carrier by active substance, then add surfactant as one or more in dispersant, stabilizing agent, wetting agent, binding agent, defoamer, disintegrant, antifreeze etc.
Bactericidal composition of the present invention, acceptable formulation in any sterilization can be processed on demand, wherein more preferably formulation is wetting powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent or microcapsule suspension-suspendinagent agent, can also make granule, seed coat agent, suspension seed-coating agent, ultra low volume liquids, missible oil.
Composition comprises following constituent content when making wetting powder: active components A 0.1% ~ 80%, active component B0.1% ~ 80%, dispersant 2% ~ 10%, wetting agent 2% ~ 10%, filler surplus.
Composition comprises following constituent content when making water dispersible granules: active components A 0.1% ~ 80%, active component B0.1% ~ 80%, dispersant 3% ~ 12%, wetting agent 1% ~ 8%, disintegrant 1% ~ 10%, binding agent 0 ~ 8%, filler surplus.
Composition comprises following constituent content when making suspending agent: active components A 0.1% ~ 50%, active component B0.1% ~ 50%, dispersant 2% ~ 10%, wetting agent 2% ~ 10%, defoamer 0.01% ~ 2%, thickener 0 ~ 2%, antifreeze 0 ~ 8%, deionized water add to 100%.
Composition comprises following constituent content when making suspension emulsion: active components A 0.1% ~ 50%, active component B0.1% ~ 50%, dispersant 2% ~ 10%, defoamer 0.01% ~ 2%, solvent 1% ~ 15%, thickener 0 ~ 2%, emulsifier 2% ~ 12%, antifreeze 0 ~ 8%, deionized water add to 100%.
Composition comprises following constituent content when making aqueous emulsion: active components A 0.1% ~ 50%, active component B0.1% ~ 50%, solvent 1% ~ 30%, emulsifier 1% ~ 15%, antifreeze 0 ~ 8%, thickener 0 ~ 2%, defoamer 0.01% ~ 2%, deionized water supply surplus.
Composition comprises following constituent content when making microemulsion: active components A 0.1% ~ 50%, active component B0.1% ~ 50%, solvent 1% ~ 30%, emulsifier 3% ~ 25%, antifreeze 0 ~ 8%, defoamer 0.01% ~ 2%, deionized water supply surplus.
Composition comprises following constituent content when making microcapsule suspending agent: active components A 0.1% ~ 50%, active component B0.1% ~ 50%, macromolecule cyst material 2% ~ 10%, dispersant 1% ~ 10%, organic solvent 1% ~ 10%, emulsifier 1% ~ 7%, defoamer 0.01% ~ 2%, pH adjusting agent 0.01% ~ 5%, deionized water add to 100%.
Composition comprises following constituent content when making microcapsule suspension-suspendinagent agent: active components A 0.5% ~ 50%, active component B0.5% ~ 50%, macromolecule cyst material 2% ~ 10%, dispersant 1% ~ 12%, wetting agent 1% ~ 8%, organic solvent 1% ~ 15%, emulsifier 1% ~ 6%, defoamer 0.01% ~ 2%, thickener 0 ~ 2%, pH adjusting agent 0.01% ~ 5%, deionized water add to 100%;
Wetting powder the key technical indexes of the present invention:
Water dispersible granules the key technical indexes of the present invention:
Suspending agent the key technical indexes of the present invention:
Suspension emulsion the key technical indexes of the present invention:
Aqueous emulsion the key technical indexes of the present invention:
Microemulsion the key technical indexes of the present invention:
Microcapsule suspending agent the key technical indexes of the present invention:
Microcapsule suspension-suspendinagent agent the key technical indexes of the present invention:
The invention has the advantages that: after (1) fluorine ether bacterium acid amides and metalaxyl, Metalaxyl-M, mandipropamid, fluazinam, Boscalid, zoxamide, fluopicolide, flutolanil are composite, there is obvious synergy and lasting effect; (2) all greater activity is had to the disease on cereal crops, legume crop, fiber crop, sugar [yielding, melon crop, fruits crop, dry fruit crop, hobby crop, root crop, oil crop, flower crop, medicinal crop, crop, green manure pasture crop; (3) decrease pesticide usage amount, reduce the residual quantity of agricultural chemicals on crop, alleviate environmental pollution; (4) to person poultry safety, Environmental compatibility is good; And preparation adhesion strength strengthens, resistance of rainwater washing against.
Embodiment
Below in conjunction with embodiment to further instruction of the present invention, the percentage in embodiment is all weight percentage, but the present invention is not limited thereto.
Application Example one
Embodiment 1 ~ 22 wetting powder
Fluorine ether bacterium acid amides, active component B, dispersant, wetting agent, filler are mixed in mixed cylinder, mixes again after airslide disintegrating mill is pulverized, wetting powder product of the present invention can be obtained, specifically in table 1.
The each component of table 1 embodiment 1 ~ 22 and weight portion
Embodiment 23 ~ 44 water dispersible granules
Fluorine ether bacterium acid amides, active component B, dispersant, wetting agent, disintegrant, filler etc. are obtained together the particle diameter needed through air-flow crushing, then add other auxiliary agents such as binding agent (can add and can not add), obtain granulation materials.Item is quantitatively sent in fluidized bed granulating dryer through granulating and after drying, water dispersible granules product of the present invention can being obtained, specifically in table 2.
The each component of table 2 embodiment 23 ~ 44 and weight portion
Embodiment 45 ~ 66 suspending agent
By dispersant, wetting agent, defoamer, thickener (can add and can not add), antifreeze (can add and can not add), mix through high speed shear, add fluorine ether bacterium acid amides, active component B, ball milling 2 ~ 3 hours in ball mill, make diameter of particle all below 5 μm, surplus deionized water is supplied, and can obtain suspending agent product of the present invention, specifically in table 3.
The each component of table 3 embodiment 45 ~ 66 and weight portion
Embodiment 67 ~ 77 suspension emulsion
Dispersant, defoamer, thickener (can add and can not add), antifreeze (can add and can not add) are mixed through high speed shear, add fluorine ether bacterium acid amides, ball milling 2 ~ 3 hours in ball mill, make diameter of particle all below 5 μm, obtained fluorine ether bacterium amide suspending agents, then by active component B, solvent, emulsifier and the direct emulsification of various auxiliary agent high speed agitators in suspending agent, surplus deionized water is supplied, obtained suspension emulsion product of the present invention, specifically in table 4.The each component of table 4 embodiment 67 ~ 77 and weight portion
Embodiment 78 ~ 88 aqueous emulsion
Fluorine ether bacterium acid amides, active component B, solvent, emulsifier are added together, make to be dissolved into homogeneous oil phase; Deionized water, antifreeze (can add and can not add), thickener (can add and can not add), defoamer are mixed, becomes homogeneous aqueous phase.Under high velocity agitation, aqueous phase is added oil phase, surplus deionized water is supplied; Aqueous emulsion product of the present invention can be obtained, specifically in table 5.The each component of table 5 embodiment 78 ~ 88 and weight portion
Metalaxyl in 1-5, Metalaxyl-M, mandipropamid, fluazinam, Boscalid, zoxamide, fluopicolide, flutolanil exchange will be shown, can novel formulation be obtained.
Embodiment 89 ~ 91 microemulsion
Fluorine ether bacterium acid amides, active component B, solvent, emulsifier, antifreeze (can add and can not add), defoamer are fully mixed into the oil phase of homogeneous transparent, under agitation slowly add deionized water, form WO emulsion, again through agitating heating, make it rapid phase inversion and become oil-in-water type, be chilled to room temperature to make it to reach balance, after filtration, surplus deionized water is supplied; Microemulsion product of the present invention can be obtained, specifically in table 6.
The each component of table 6 embodiment 89 ~ 91 and weight portion
Embodiment 92,93 microcapsule suspending agent
By fluorine ether bacterium acid amides, active component B, macromolecule cyst material, solvent, make to be dissolved into homogeneous oil phase, in a shear condition, oil phase is joined in the aqueous phase solution containing emulsifier, pH adjusting agent, dispersant, surplus deionized water is supplied, bi-material reacts at oil-water interfaces, forms macromolecule cyst wall, makes the finely disseminated microcapsule suspending agent product of the present composition.Specifically in table 7.
Table 7 embodiment 92,93 each component and weight portion
Embodiment 94,95 microcapsule suspension-suspendinagent agent
By active component B, macromolecule cyst material, solvent, make to be dissolved into homogeneous oil phase, oil phase is joined in a shear condition in the aqueous phase solution containing emulsifier, pH adjusting agent, make finely disseminated microcapsule suspending agent.Dispersant, wetting agent, defoamer, thickener (can add and can not add) are mixed through high speed shear, add fluorine ether bacterium acid amides, ball milling 2 ~ 3 hours in ball mill, make diameter of particle all below 5 μm, obtained suspending agent, then join in the aqueous phase solution of micro-capsule suspension by suspending agent, deionized water supplies surplus, make the finely disseminated microcapsule suspension-suspendinagent agent product of the present composition, specifically in table 8.
Table 8 embodiment 94,95 each component and weight portion
The embodiment of the present invention is the method adopting Toxicity Determination and field trial to combine.First pass through Toxicity Determination, synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR<0.5 is antagonism, 0.5≤SR≤1.5 are summation action, SR>1.5 is synergistic effect, on this basis, then carry out field trial.
Test method: determine that after the effective inhibition concentration scope of each medicament, medicament establishes 5 dosage process respectively by active constituent content through prerun, if clear water contrast.Carry out with reference to " farm-chemical indoor determination test rule bactericide ", adopt mycelial growth rate method to measure medicament to the virulence of crop germ.Measure colony diameter by right-angled intersection method after 72h, calculate each process net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), liquor strength (μ g/mL) converts logarithm value (x) to, try to achieve virulence regression equation (y=a+bx) with method of least squares, and calculate the EC of often kind of medicament thus
50value.Calculate two medicament different ratio synergies ratio (SR) according to Wadley method, SR<0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR>1.5 is synergistic effect simultaneously.Computing formula is as follows:
Wherein: a, b are respectively active components A and the ratio of active component B shared by combination;
A is fluorine ether bacterium acid amides; B is selected from the one in metalaxyl, Metalaxyl-M, mandipropamid, fluazinam, Boscalid, zoxamide, fluopicolide or flutolanil.
Application Example two:
For examination disease: cucumber downy mildew; Test medicine provides by applicant.
Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination fluorine ether bacterium acid amides and the former medicine of metalaxyl and the two different ratio mixture.Toxicity test result
Table 9 fluorine ether bacterium acid amides and the composite toxicity test analysis of results table to cucumber downy mildew of metalaxyl
As shown in Table 9, fluorine ether bacterium acid amides and metalaxyl proportioning are all greater than 1.5 when 1:80 ~ 80:1 to the synergy ratio SR of cucumber downy mildew, both explanations mixture within the scope of 1:80 ~ 80:1 all shows synergistic effect, when the proportioning of fluorine ether bacterium acid amides and metalaxyl is at 15:1 ~ 1:25, synergistic effect is more outstanding, and synergy ratio is all more than 2.25; When the proportioning of fluorine ether bacterium acid amides and metalaxyl is at 4:1 ~ 1:14, synergistic effect is more outstanding, and synergy ratio is all more than 2.35, and when fluorine ether bacterium acid amides and metalaxyl weight ratio are 1:5, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example three:
For examination disease: downy mildew of garpe; Test medicine provides by applicant.
Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination fluorine ether bacterium acid amides and the former medicine of Metalaxyl-M and the two different ratio mixture.
Toxicity test result
Table 10 fluorine ether bacterium acid amides and the composite toxicity test analysis of results table to downy mildew of garpe of Metalaxyl-M
As shown in Table 10, fluorine ether bacterium acid amides and Metalaxyl-M proportioning are all greater than 1.5 when 1:80 ~ 80:1 to the synergy ratio SR of downy mildew of garpe, both explanations mixture within the scope of 1:80 ~ 80:1 all shows synergistic effect, when the proportioning of fluorine ether bacterium acid amides and Metalaxyl-M is at 20:1 ~ 1:20, synergistic effect is more outstanding, and synergy ratio is all more than 2.35; When the proportioning of fluorine ether bacterium acid amides and Metalaxyl-M is at 9:1 ~ 1:9, synergistic effect is more outstanding, and synergy ratio is all more than 2.40, and when fluorine ether bacterium acid amides and Metalaxyl-M weight ratio are 1:1, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example four:
For examination disease: capsicum epidemic disease; Test medicine provides by applicant.
Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination fluorine ether bacterium acid amides and the former medicine of mandipropamid and the two different ratio mixture.
Toxicity test result
Table 11 fluorine ether bacterium acid amides and the composite toxicity test analysis of results table to capsicum epidemic disease of mandipropamid
As shown in Table 11, fluorine ether bacterium acid amides and mandipropamid proportioning are all greater than 1.5 when 1:80 ~ 80:1 to the synergy ratio SR of capsicum epidemic disease, both explanations mixture within the scope of 1:80 ~ 80:1 all shows synergistic effect, when the proportioning of fluorine ether bacterium acid amides and mandipropamid is at 20:1 ~ 1:20, synergistic effect is more outstanding, and synergy ratio is all more than 2.25; When the proportioning of fluorine ether bacterium acid amides and mandipropamid is at 9:1 ~ 1:9, synergistic effect is more outstanding, and synergy ratio is all more than 2.35, and when fluorine ether bacterium acid amides and mandipropamid weight ratio are 1:1, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example five:
For examination disease: potato late blight; Test medicine provides by applicant.
Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination fluorine ether bacterium acid amides and the former medicine of fluazinam and the two different ratio mixture.
Toxicity test result
Table 12 fluorine ether bacterium acid amides and the composite toxicity test analysis of results table to potato late blight of fluazinam
As shown in Table 12, fluorine ether bacterium acid amides and fluazinam proportioning are all greater than 1.5 when 1:80 ~ 80:1 to the synergy ratio SR of potato late blight, both explanations mixture within the scope of 1:80 ~ 80:1 all shows synergistic effect, when the proportioning of fluorine ether bacterium acid amides and fluazinam is at 20:1 ~ 1:20, synergistic effect is more outstanding, and synergy ratio is all more than 2.25; When fluorine ether bacterium acid amides and fluazinam weight ratio are 1:2, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example six:
For examination disease: grape grey mould; Test medicine provides by applicant.
Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination fluorine ether bacterium acid amides and the former medicine of Boscalid and the two different ratio mixture.
Toxicity test result
Table 13 fluorine ether bacterium acid amides and the composite toxicity test analysis of results table to grape grey mould of Boscalid
As shown in Table 13, fluorine ether bacterium acid amides and Boscalid proportioning are all greater than 1.5 when 1:80 ~ 80:1 to the synergy ratio SR of grape grey mould, both explanations mixture within the scope of 1:80 ~ 80:1 all shows synergistic effect, when the proportioning of fluorine ether bacterium acid amides and Boscalid is at 20:1 ~ 1:20, synergistic effect is more outstanding, and synergy ratio is all more than 2.25; When fluorine ether bacterium acid amides and Boscalid weight ratio are 1:2, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example seven:
For examination disease: powdery mildew of cucumber; Test medicine provides by applicant.
Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination fluorine ether bacterium acid amides and the former medicine of zoxamide and the two different ratio mixture.
Toxicity test result
Table 14 fluorine ether bacterium acid amides and the composite toxicity test analysis of results table to powdery mildew of cucumber of zoxamide
As shown in Table 14, fluorine ether bacterium acid amides and zoxamide proportioning are all greater than 1.5 when 1:80 ~ 80:1 to the synergy ratio SR of powdery mildew of cucumber, both explanations mixture within the scope of 1:80 ~ 80:1 all shows synergistic effect, when the proportioning of fluorine ether bacterium acid amides and zoxamide is at 20:1 ~ 1:20, synergistic effect is more outstanding, and synergy ratio is all more than 2.25; When fluorine ether bacterium acid amides and zoxamide weight ratio are 2:3, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example eight:
For examination disease: rice blast; Test medicine provides by applicant.
Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination fluorine ether bacterium acid amides and the former medicine of fluopicolide and the two different ratio mixture.
Toxicity test result
Table 15 fluorine ether bacterium acid amides and the composite toxicity test analysis of results table to rice blast of fluopicolide
As shown in Table 15, fluorine ether bacterium acid amides and fluopicolide proportioning are all greater than 1.5 when 1:80 ~ 80:1 to the synergy ratio SR of rice blast, both explanations mixture within the scope of 1:80 ~ 80:1 all shows synergistic effect, when the proportioning of fluorine ether bacterium acid amides and fluopicolide is at 20:1 ~ 1:20, synergistic effect is more outstanding, and synergy ratio is all more than 2.30; When fluorine ether bacterium acid amides and fluopicolide weight ratio are 1:2, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example nine:
For examination disease: rice sheath blight disease; Test medicine provides by applicant.
Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination flutolanil and the former medicine of flutolanil and the two different ratio mixture.
Toxicity test result
Table 16 flutolanil and the composite toxicity test analysis of results table to rice sheath blight disease of flutolanil
As shown in Table 16, flutolanil and flutolanil proportioning are all greater than 1.5 when 1:80 ~ 80:1 to the synergy ratio SR of rice sheath blight disease, both explanations mixture within the scope of 1:80 ~ 80:1 all shows synergistic effect, when the proportioning of flutolanil and flutolanil is at 15:1 ~ 1:25, synergistic effect is more outstanding, and synergy ratio is all more than 2.25; When flutolanil and flutolanil weight ratio are 1:3, synergy ratio is maximum, and synergistic effect is the most obvious.
Testing through applicant the optimum ratio finding fluorine ether bacterium acid amides and metalaxyl or flutolanil is 15:1, 14:1, 13:1, 12:1, 11:1, 10:1, 9:1, 8:1, 7:1, 6:1, 5:1, 4:1, 3:1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:11, 1:12, 1:13, 1:14, 1:15, 1:16, 1:17, 1:18, 1:19, 1:20, 1:21, 1:22, 1:23, 1:24, 1:25, fluorine ether bacterium acid amides and Metalaxyl-M, mandipropamid, fluazinam, Boscalid, the optimum ratio of zoxamide or fluopicolide is 20:1, 19:1, 18:1, 17:1, 16:1, 15:1, 14:1, 13:1, 12:1, 11:1, 10:1, 9:1, 8:1, 7:1, 6:1, 5:1, 4:1, 3:1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:11, 1:12, 1:13, 1:14, 1:15, 1:16, 1:17, 1:18, 1:19, 1:20 synergistic effect is comparatively obvious.
Find through test: fluorine ether bacterium acid amides and active component B composite after to the downy mildew in various crop, epidemic disease, rust, balck shank, foot rot, powdery mildew, root rot, damping off, seedling rot, club root, gray mold, dish obstructs mould, brown spot, rice blast or banded sclerotial blight control obvious synergistic effect, synergy ratio SR is all greater than 1.5.
Effect experiment part: test medicine is researched and developed by applicant, there is provided, contrast medicament 50% fluorine ether bacterium acid amides wetting powder (autogamy), 25% metalaxyl wetting powder (commercial), 350g/l Metalaxyl-M seed treatment emulsion (commercial), 23.4% mandipropamid suspending agent (commercial), 500g/l fluazinam suspending agent (autogamy), 50% Boscalid water dispersible granules (commercial), 24% zoxamide suspending agent (commercial), 25% fluopicolide suspending agent (autogamy), 20% flutolanil wetting powder (commercial).
Application Example ten fluorine ether bacterium acid amides and active component B and the composite control cucumber downy mildew test of pesticide effectiveness thereof.This test arrangement is at Xianyang, Shanxi province suburban area, and investigation cucumber downy mildew disease index before medicine, in the dispenser of disease initial stage of origination, 3 days, 10 days, 20 days investigation disease indexes after dispenser also calculate preventive effect.Result of the test is as follows:
Table 17 fluorine ether bacterium acid amides and active component B and the composite control cucumber downy mildew test of pesticide effectiveness thereof
As can be seen from Table 17, fluorine ether bacterium acid amides and active component B composite after effectively can prevent and treat cucumber downy mildew, through applicant test find fluorine ether bacterium acid amides and active component B composite after also can effectively prevent and treat powdery mildew of cucumber or gray mold of cucumber, control efficiency is all higher than 97%, be better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example ten monofluoro-ether bacterium acid amides and active component B and the composite control tomato blight test of pesticide effectiveness thereof.This test arrangement is at Xian District, Shanxi Province suburban area, and investigation tomato blight disease index before medicine, in the dispenser of disease initial stage of origination, 3 days, 10 days, 20 days investigation disease indexes after dispenser also calculate preventive effect.Result of the test is as follows:
Table 18 fluorine ether bacterium acid amides and active component B and the composite control tomato blight test of pesticide effectiveness thereof
As can be seen from Table 18, fluorine ether bacterium acid amides and active component B composite after effectively can prevent and treat tomato blight, control efficiency, all higher than 97%, is better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example ten difluoro ether bacterium acid amides and active component B and the composite control rice blast test of pesticide effectiveness thereof.This test arrangement is at Shaanxi Province's Hanzhong City, and investigation rice blast disease index before medicine, in the dispenser of disease initial stage of origination, 3 days, 10 days, 20 days investigation disease indexes after dispenser also calculate preventive effect.Result of the test is as follows:
Table 19 fluorine ether bacterium acid amides and active component B and the composite control rice blast test of pesticide effectiveness thereof
As can be seen from Table 19, fluorine ether bacterium acid amides and active component B composite after effectively can prevent and treat rice blast, test through applicant and find that fluorine ether bacterium acid amides and active component B also effectively can prevent and treat paddy rice damping off, rice sheath blight disease or Achlya spp disease after composite, control efficiency is all higher than 97%, be better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example ten trifluoro bacterium acid amides and active component B and the composite control grape grey mould test of pesticide effectiveness thereof.This test arrangement is in Weinan City Dali County, Shaanxi Province, and investigation grape grey mould disease index before medicine, in the dispenser of disease initial stage of origination, 3 days, 10 days, 20 days investigation disease indexes after dispenser also calculate preventive effect.Result of the test is as follows:
Table 20 fluorine ether bacterium acid amides and active component B and the composite control grape grey mould test of pesticide effectiveness thereof
As can be seen from Table 20, fluorine ether bacterium acid amides and active component B composite after effectively can prevent and treat grape grey mould, through applicant test find fluorine ether bacterium acid amides and active component B composite after also can effectively prevent and treat downy mildew of garpe or grape powdery mildew, control efficiency is all higher than 97%, be better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
After draw through tests different local throughout the country, fluorine ether bacterium acid amides and active component B is composite obstructs the preventive effect of mould, the Common Diseases such as brown spot, rice blast or banded sclerotial blight all more than 95% to the downy mildew in various crop, epidemic disease, rust, balck shank, foot rot, powdery mildew, root rot, damping off, seedling rot, club root, gray mold, dish afterwards, be better than single dose preventive effect, synergistic effect is obvious.
Claims (6)
1. the compound highly effective bactericidal composition of a fluorine-containing ether bacterium acid amides, effective active composition is active components A and active component B, it is characterized in that: active components A and active component B weight ratio are 1:80 ~ 80:1, described active components A is selected from fluorine ether bacterium acid amides, and active component B is selected from the one in metalaxyl, Metalaxyl-M, mandipropamid, fluazinam, Boscalid, zoxamide, fluopicolide or flutolanil.
2. the compound highly effective bactericidal composition of fluorine-containing ether bacterium acid amides according to claim 1, is characterized in that: the weight ratio of active components A and active component B is 1:40 ~ 40:1.
3. the compound highly effective bactericidal composition of fluorine-containing ether bacterium acid amides according to claim 2, is characterized in that:
The weight ratio of fluorine ether bacterium acid amides and metalaxyl is 15:1 ~ 1:25;
The weight ratio of fluorine ether bacterium acid amides and Metalaxyl-M is 20:1 ~ 1:20;
The weight ratio of fluorine ether bacterium acid amides and mandipropamid is 20:1 ~ 1:20;
The weight ratio of fluorine ether bacterium acid amides and fluazinam is 20:1 ~ 1:20;
The weight ratio of fluorine ether bacterium acid amides and Boscalid is 20:1 ~ 1:20;
The weight ratio of fluorine ether bacterium acid amides and zoxamide is 20:1 ~ 1:20;
The weight ratio of fluorine ether bacterium acid amides and fluopicolide is 20:1 ~ 1:20;
The weight ratio of fluorine ether bacterium acid amides and flutolanil is 15:1 ~ 1:25.
4. the compound highly effective bactericidal composition of fluorine-containing ether bacterium acid amides according to any one of claim 1 to 3, is characterized in that: composition makes wetting powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent or microcapsule suspension-suspendinagent agent.
5. the compound highly effective bactericidal composition of fluorine-containing ether bacterium acid amides according to claim 4 is for preventing and treating the purposes of disease on crops.
6. purposes according to claim 5, is characterized in that: described disease is downy mildew, epidemic disease, rust, balck shank, foot rot, powdery mildew, root rot, damping off, seedling rot, club root, gray mold, dish stalk mould, brown spot, rice blast or banded sclerotial blight.
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| CN201810578205.6A CN108849906A (en) | 2013-09-02 | 2013-09-02 | A kind of combination sterilization composition of fluorine-containing ether bacterium amide |
| CN201310403776.3A CN104412982B (en) | 2013-09-02 | 2013-09-02 | A kind of compound highly effective bactericidal composition of fluorine-containing ether bacterium amide |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105028417A (en) * | 2015-06-08 | 2015-11-11 | 柳州市天姿园艺有限公司 | Composition for preventing and treating phytophthora root rot of cymbidium kanran |
| CN106689136A (en) * | 2017-01-10 | 2017-05-24 | 山东省联合农药工业有限公司 | High-efficiency bactericidal composition containing fluoroether bacteria amide and use thereof |
| CN106942252A (en) * | 2017-04-01 | 2017-07-14 | 山东省联合农药工业有限公司 | A kind of composite bactericide of fluorine-containing ether bacterium acid amides |
| WO2020225242A1 (en) | 2019-05-08 | 2020-11-12 | Bayer Aktiengesellschaft | Active compound combination |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102086173B (en) * | 2010-09-07 | 2012-08-22 | 山东省联合农药工业有限公司 | Tetrafluorophenoxy nicotinamide compound as well as preparation method and application thereof for sterilizing |
| CN102754650A (en) * | 2012-07-24 | 2012-10-31 | 山东省联合农药工业有限公司 | Desflurane bacteria amide compound bactericide |
| CN102792952B (en) * | 2012-09-12 | 2014-02-12 | 山东棉花研究中心 | Bactericide composition for preventing and controlling cotton disease |
| CN102845426A (en) * | 2012-09-19 | 2013-01-02 | 山东省联合农药工业有限公司 | Bactericide combination containing fluorine ether bacteria amide and chlorothalonil |
-
2013
- 2013-09-02 CN CN201810578205.6A patent/CN108849906A/en active Pending
- 2013-09-02 CN CN201310403776.3A patent/CN104412982B/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105028417A (en) * | 2015-06-08 | 2015-11-11 | 柳州市天姿园艺有限公司 | Composition for preventing and treating phytophthora root rot of cymbidium kanran |
| CN106689136A (en) * | 2017-01-10 | 2017-05-24 | 山东省联合农药工业有限公司 | High-efficiency bactericidal composition containing fluoroether bacteria amide and use thereof |
| CN106942252A (en) * | 2017-04-01 | 2017-07-14 | 山东省联合农药工业有限公司 | A kind of composite bactericide of fluorine-containing ether bacterium acid amides |
| WO2020225242A1 (en) | 2019-05-08 | 2020-11-12 | Bayer Aktiengesellschaft | Active compound combination |
| CN113840533A (en) * | 2019-05-08 | 2021-12-24 | 拜耳公司 | Active compound combinations |
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| CN104412982B (en) | 2018-08-03 |
| CN108849906A (en) | 2018-11-23 |
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