CN108849906A - A kind of combination sterilization composition of fluorine-containing ether bacterium amide - Google Patents
A kind of combination sterilization composition of fluorine-containing ether bacterium amide Download PDFInfo
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- CN108849906A CN108849906A CN201810578205.6A CN201810578205A CN108849906A CN 108849906 A CN108849906 A CN 108849906A CN 201810578205 A CN201810578205 A CN 201810578205A CN 108849906 A CN108849906 A CN 108849906A
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- Prior art keywords
- ether bacterium
- bacterium amide
- fluorine
- weight ratio
- fluorine ether
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 title claims abstract description 216
- 241000894006 Bacteria Species 0.000 title claims abstract description 119
- 150000001408 amides Chemical class 0.000 title claims abstract description 110
- 239000011737 fluorine Substances 0.000 title claims abstract description 109
- 229910052731 fluorine Inorganic materials 0.000 title claims abstract description 109
- 239000000203 mixture Substances 0.000 title claims abstract description 49
- 125000001153 fluoro group Chemical group F* 0.000 title claims abstract description 11
- 230000001954 sterilising effect Effects 0.000 title claims description 10
- 238000004659 sterilization and disinfection Methods 0.000 title claims description 9
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims abstract description 98
- 239000000470 constituent Substances 0.000 claims abstract description 54
- 201000010099 disease Diseases 0.000 claims abstract description 46
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 46
- 239000005786 Flutolanil Substances 0.000 claims abstract description 24
- PTCGDEVVHUXTMP-UHFFFAOYSA-N flutolanil Chemical compound CC(C)OC1=CC=CC(NC(=O)C=2C(=CC=CC=2)C(F)(F)F)=C1 PTCGDEVVHUXTMP-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000005808 Metalaxyl-M Substances 0.000 claims abstract description 19
- ZQEIXNIJLIKNTD-GFCCVEGCSA-N metalaxyl-M Chemical compound COCC(=O)N([C@H](C)C(=O)OC)C1=C(C)C=CC=C1C ZQEIXNIJLIKNTD-GFCCVEGCSA-N 0.000 claims abstract description 19
- 239000005807 Metalaxyl Substances 0.000 claims abstract description 18
- ZQEIXNIJLIKNTD-UHFFFAOYSA-N methyl N-(2,6-dimethylphenyl)-N-(methoxyacetyl)alaninate Chemical compound COCC(=O)N(C(C)C(=O)OC)C1=C(C)C=CC=C1C ZQEIXNIJLIKNTD-UHFFFAOYSA-N 0.000 claims abstract description 18
- SOUGWDPPRBKJEX-UHFFFAOYSA-N 3,5-dichloro-N-(1-chloro-3-methyl-2-oxopentan-3-yl)-4-methylbenzamide Chemical compound ClCC(=O)C(C)(CC)NC(=O)C1=CC(Cl)=C(C)C(Cl)=C1 SOUGWDPPRBKJEX-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000005782 Fluopicolide Substances 0.000 claims abstract description 17
- 239000005863 Zoxamide Substances 0.000 claims abstract description 17
- GBOYJIHYACSLGN-UHFFFAOYSA-N fluopicolide Chemical compound ClC1=CC(C(F)(F)F)=CN=C1CNC(=O)C1=C(Cl)C=CC=C1Cl GBOYJIHYACSLGN-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000005740 Boscalid Substances 0.000 claims abstract description 16
- 239000005780 Fluazinam Substances 0.000 claims abstract description 16
- WYEMLYFITZORAB-UHFFFAOYSA-N boscalid Chemical compound C1=CC(Cl)=CC=C1C1=CC=CC=C1NC(=O)C1=CC=CN=C1Cl WYEMLYFITZORAB-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229940118790 boscalid Drugs 0.000 claims abstract description 16
- UZCGKGPEKUCDTF-UHFFFAOYSA-N fluazinam Chemical compound [O-][N+](=O)C1=CC(C(F)(F)F)=C(Cl)C([N+]([O-])=O)=C1NC1=NC=C(C(F)(F)F)C=C1Cl UZCGKGPEKUCDTF-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000000375 suspending agent Substances 0.000 claims description 22
- 235000007164 Oryza sativa Nutrition 0.000 claims description 16
- 235000009566 rice Nutrition 0.000 claims description 16
- 241000233679 Peronosporaceae Species 0.000 claims description 15
- 239000003094 microcapsule Substances 0.000 claims description 14
- 239000004563 wettable powder Substances 0.000 claims description 9
- 241000221785 Erysiphales Species 0.000 claims description 8
- 239000000839 emulsion Substances 0.000 claims description 8
- 239000004562 water dispersible granule Substances 0.000 claims description 7
- 239000004530 micro-emulsion Substances 0.000 claims description 6
- 239000004548 suspo-emulsion Substances 0.000 claims description 6
- 208000010801 foot rot Diseases 0.000 claims description 4
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 4
- 240000007594 Oryza sativa Species 0.000 claims 1
- 230000002195 synergetic effect Effects 0.000 abstract description 40
- 150000001875 compounds Chemical class 0.000 abstract description 24
- KWLVWJPJKJMCSH-UHFFFAOYSA-N 2-(4-chlorophenyl)-N-{2-[3-methoxy-4-(prop-2-yn-1-yloxy)phenyl]ethyl}-2-(prop-2-yn-1-yloxy)acetamide Chemical compound C1=C(OCC#C)C(OC)=CC(CCNC(=O)C(OCC#C)C=2C=CC(Cl)=CC=2)=C1 KWLVWJPJKJMCSH-UHFFFAOYSA-N 0.000 abstract description 18
- 239000005804 Mandipropamid Substances 0.000 abstract description 18
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 10
- 239000000575 pesticide Substances 0.000 abstract description 5
- 206010059866 Drug resistance Diseases 0.000 abstract description 2
- 238000012271 agricultural production Methods 0.000 abstract description 2
- 238000003912 environmental pollution Methods 0.000 abstract description 2
- 244000144972 livestock Species 0.000 abstract description 2
- 230000007613 environmental effect Effects 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 35
- 239000003814 drug Substances 0.000 description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 21
- 231100000820 toxicity test Toxicity 0.000 description 17
- 241000209094 Oryza Species 0.000 description 15
- 230000003449 preventive effect Effects 0.000 description 15
- 239000003795 chemical substances by application Substances 0.000 description 13
- 239000002270 dispersing agent Substances 0.000 description 13
- 240000008067 Cucumis sativus Species 0.000 description 12
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 12
- 239000002518 antifoaming agent Substances 0.000 description 12
- 239000008367 deionised water Substances 0.000 description 12
- 229910021641 deionized water Inorganic materials 0.000 description 12
- 239000012071 phase Substances 0.000 description 12
- 150000001412 amines Chemical class 0.000 description 11
- 238000002474 experimental method Methods 0.000 description 10
- 239000002904 solvent Substances 0.000 description 10
- 230000002528 anti-freeze Effects 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 239000003995 emulsifying agent Substances 0.000 description 9
- 230000002265 prevention Effects 0.000 description 9
- 238000004458 analytical method Methods 0.000 description 8
- 238000013401 experimental design Methods 0.000 description 8
- 230000005764 inhibitory process Effects 0.000 description 8
- 230000003285 pharmacodynamic effect Effects 0.000 description 8
- 239000002562 thickening agent Substances 0.000 description 8
- 239000000080 wetting agent Substances 0.000 description 8
- 241000219095 Vitis Species 0.000 description 7
- 235000009754 Vitis X bourquina Nutrition 0.000 description 7
- 235000012333 Vitis X labruscana Nutrition 0.000 description 7
- 235000014787 Vitis vinifera Nutrition 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 238000013329 compounding Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 125000002252 acyl group Chemical group 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 5
- 206010011732 Cyst Diseases 0.000 description 4
- 241000227653 Lycopersicon Species 0.000 description 4
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 4
- 208000031513 cyst Diseases 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000000945 filler Substances 0.000 description 4
- 238000011835 investigation Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 229920002521 macromolecule Polymers 0.000 description 4
- 239000003002 pH adjusting agent Substances 0.000 description 4
- 241001530056 Athelia rolfsii Species 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 235000002566 Capsicum Nutrition 0.000 description 3
- 244000061456 Solanum tuberosum Species 0.000 description 3
- 235000002595 Solanum tuberosum Nutrition 0.000 description 3
- BAOWVDHYZBLYMB-UHFFFAOYSA-N [F].C1=CC=NC=C1 Chemical compound [F].C1=CC=NC=C1 BAOWVDHYZBLYMB-UHFFFAOYSA-N 0.000 description 3
- 239000011149 active material Substances 0.000 description 3
- 230000008485 antagonism Effects 0.000 description 3
- 239000008346 aqueous phase Substances 0.000 description 3
- 230000010165 autogamy Effects 0.000 description 3
- 238000000498 ball milling Methods 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 239000001390 capsicum minimum Substances 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 230000001018 virulence Effects 0.000 description 3
- 240000008574 Capsicum frutescens Species 0.000 description 2
- 241000219112 Cucumis Species 0.000 description 2
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 206010067482 No adverse event Diseases 0.000 description 2
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 2
- 239000012752 auxiliary agent Substances 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 210000003608 fece Anatomy 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000000855 fungicidal effect Effects 0.000 description 2
- 239000000417 fungicide Substances 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 235000021374 legumes Nutrition 0.000 description 2
- 239000010871 livestock manure Substances 0.000 description 2
- UJMWVICAENGCRF-UHFFFAOYSA-N oxygen difluoride Chemical compound FOF UJMWVICAENGCRF-UHFFFAOYSA-N 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 241000208293 Capsicum Species 0.000 description 1
- 241000510928 Erysiphe necator Species 0.000 description 1
- 241001330975 Magnaporthe oryzae Species 0.000 description 1
- 241000233654 Oomycetes Species 0.000 description 1
- -1 acyl Amine Chemical class 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000002242 deionisation method Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000009313 farming Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000005243 fluidization Methods 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000009775 high-speed stirring Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000002420 orchard Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
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- 230000001225 therapeutic effect Effects 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of compound highly effective bactericidal compositions of fluorine-containing ether bacterium amide, the bactericidal composition containing active components A and active constituent B, and wherein active components A is selected from fluorine ether bacterium amide, and active constituent B is selected from any one following compound：Metalaxyl, Metalaxyl-M, mandipropamid, fluazinam, Boscalid, zoxamide, fluopicolide, flutolanil, and active components A and the weight ratio of active constituent B are 1 ︰, 80 ~ 80 ︰ 1.The present composition has synergistic effect to the multiple diseases for endangering agricultural production, reduces pesticide usage amount, reduces residual quantity of the pesticide on crop, alleviate environmental pollution, to safety of human and livestock, Environmental compatibility is good, and disease is not likely to produce drug resistance.
Description
The application is divisional application, and original application is a logical patent application " a kind of compound sterilizing group for fluorine-containing ether bacterium amide
Close object ", original application application No. is 201310403776.3, original application date 2013.09.02
Technical field
The invention belongs to technical field of pesticide, are related to a kind of compound highly effective bactericidal composition of fluorine-containing ether bacterium amide in farming
Application in object disease.
Background technique
Fluorine ether bacterium amide is a kind of amides wide-spectrum bactericide, has very high bioactivity to Oomycete fungal germ, tool
There are preferable protection and therapeutic effect, the phonetic bacterium amide of fluorine has stronger absorbability, can absorb by cauline leaf, upward by plant lower part
The conduction of portion direction, is distributed along plant xylem to whole strain crop.Metalaxyl, Metalaxyl-M, mandipropamid, fluazinam, pyridine acyl
Bacterium amine, zoxamide, fluopicolide, flutolanil belong to common fungicide, are widely used in the disease of crops.
However, in the real process of agricultural production, the problem of controlling disease most easily produces is the production of disease drug resistance
It is raw.Different cultivars ingredient is compounded, and is to prevent and treat the very common method of resistance disease.Heterogeneity is compounded, according to reality
Application effect, to judge that certain compounding is synergy, adduction or antagonism.In most cases, the compounding effect of sterilization
All be additive effect, really have the compounding of synergistic effect seldom, especially synergistic effect clearly, synergy ratio it is very high multiple
With just less.It studies, is found fluorine ether bacterium amide and metalaxyl, Metalaxyl-M, mandipropamid, fluorine pyridine by inventor
Good synergistic effect can be generated after amine, Boscalid, zoxamide, fluopicolide, flutolanil compounding, and about fluorine ether
Bacterium amide and metalaxyl, Metalaxyl-M, mandipropamid, fluazinam, Boscalid, zoxamide, fluopicolide, flutolanil
The relevant report of compounding not yet discloses.
Summary of the invention
The purpose of the present invention is to propose to a kind of with synergistic function, the fluorine-containing ether bacterium acyl that use cost is low, preventive effect is good
The compound highly effective bactericidal composition of amine.
The compound highly effective bactericidal composition of fluorine-containing ether bacterium amide proposed by the present invention contains active components A and active constituent B,
Activity is divided into A and active constituent B weight ratio is 1 ︰, 80~80 ︰ 1, and the active components A is selected from fluorine ether bacterium amide, active constituent
B is in metalaxyl, Metalaxyl-M, mandipropamid, fluazinam, Boscalid, zoxamide, fluopicolide, flutolanil
One kind, active components A and the preferred weight ratio of active constituent B are 1 ︰, 40~40 ︰ 1；More preferably fluorine ether bacterium amide and first frost
The weight ratio of spirit is 15:1~1:25, the weight ratio of fluorine ether bacterium amide and Metalaxyl-M is 20:1~1:20, fluorine ether bacterium amide and
The weight ratio of mandipropamid is 20:1~1:20, the weight ratio of fluorine ether bacterium amide and fluazinam is 20:1~1:20, fluorine ether bacterium
The weight ratio of amide and Boscalid is 20:1~1:20, the weight ratio of fluorine ether bacterium amide and zoxamide is 20:1~1:20,
The weight ratio of fluorine ether bacterium amide and fluopicolide is 20:1~1:20, the weight ratio of fluorine ether bacterium amide and flutolanil is 15:1~
1:25；Most preferably the weight ratio of fluorine ether bacterium amide and metalaxyl is 4:1~1:14, the weight of fluorine ether bacterium amide and Metalaxyl-M
Than being 9:1~1:9, the weight ratio of fluorine ether bacterium amide and mandipropamid is 9:1~1:9, the weight of fluorine ether bacterium amide and fluazinam
Amount is than being 9:1~1:9, the weight ratio of fluorine ether bacterium amide and Boscalid is 9:1~1:9, fluorine ether bacterium amide and zoxamide
Weight ratio is 9:1~1:9, the weight ratio of fluorine ether bacterium amide and fluopicolide is 9:1~1:9, fluorine ether bacterium amide and flutolanil
Weight ratio be 4:1~1:9.
The compound highly effective bactericidal composition of fluorine-containing ether bacterium amide proposed by the present invention is used to prevent and treat the use of disease on crops
On the way, the crops include cereal crops, legume crop, fibre crops, sugar crop, melon crop, fruits crop, do
Orchard crop, hobby crop, root crop, oil crops, flower crop, medicinal crop, crop, green manure herbage make
Object；The disease include downy mildew, epidemic disease, rust, balck shank, foot rot, powdery mildew, root rot, samping off, seedling rot,
Clubroot, gray mold, disk obstruct mould, brown spot, rice blast or banded sclerotial blight.
Active components A, the weight ratio of active constituent B are 1 ︰, 80~80 ︰ 1.The weight hundred of active component in usual composition
Divide content for the 0.5%~90% of total weight, preferably 5%~80%.According to different preparation types, active component content
Range is different.In general, liquid preparation contains by weight 1%~70% active material, preferably 5%~50%；
Solid pharmaceutical preparation contains by weight 5%~80% active material, preferably 10%~80%.
In bactericidal composition of the invention at least contain a kind of surfactant, in favor of application when active component in water
Dispersion.Surface-active contents are the 5%~30% of total formulation weight, and surplus is solid or liquid diluent.
Bactericidal composition of the invention can used before through dilution or directly by user.Its preparation can be by usual
Processing method known in those skilled in the art preparation, i.e., after active material being mixed with liquid solvent or solid carrier,
Add one of surfactant such as dispersing agent, stabilizer, wetting agent, binder, defoaming agent, disintegrating agent, antifreeze etc.
Or it is several.
Bactericidal composition of the invention can be processed into acceptable dosage form in any sterilization, wherein more preferably as needed
Dosage form be that wettable powder, water dispersible granules, suspending agent, suspoemulsion, aqueous emulsion, microemulsion, microcapsule suspending agent or micro-capsule are outstanding
Floating-suspending agent, can also be made granule, seed coat agent, suspension seed-coating agent, ultra low volume liquids, missible oil.
Comprising following constituent content when wettable powder is made in composition：Active components A 0.1%~80%, active constituent
B0.1%~80%, dispersing agent 2%~10%, wetting agent 2%~10%, filler surplus.
Composition includes following constituent content when water dispersible granules are made：Active components A 0.1%~80%, active constituent
B0.1%~80%, dispersing agent 3%~12%, wetting agent 1%~8%, disintegrating agent 1%~10%, binder 0~8%, filler
Surplus.
Composition includes following constituent content when suspending agent is made：Active components A 0.1%~50%, active constituent
B0.1%~50%, dispersing agent 2%~10%, wetting agent 2%~10%, defoaming agent 0.01%~2%, thickener 0~2%,
Antifreeze 0~8%, deionized water add to 100%.
Composition includes following constituent content when suspoemulsion is made：Active components A 0.1%~50%, active constituent
B0.1%~50%, dispersing agent 2%~10%, defoaming agent 0.01%~2%, solvent 1%~15%, thickener 0~2%, cream
Agent 2%~12%, antifreeze 0~8%, deionized water add to 100%.
Comprising following constituent content when aqueous emulsion is made in composition：Active components A 0.1%~50%, active constituent
B0.1%~50%, solvent 1%~30%, emulsifier 1%~15%, antifreeze 0~8%, thickener 0~2%, defoaming agent
0.01%~2%, deionized water supplies surplus.
Comprising following constituent content when microemulsion is made in composition：Active components A 0.1%~50%, active constituent
B0.1%~50%, emulsifier 3%~25%, antifreeze 0~8%, defoaming agent 0.01%~2%, is gone solvent 1%~30%
Ionized water supplies surplus.
Composition includes following constituent content when microcapsule suspending agent is made：Active components A 0.1%~50%, active constituent
B0.1%~50%, macromolecule cyst material 2%~10%, dispersing agent 1%~10%, organic solvent 1%~10%, emulsifier
1%~7%, defoaming agent 0.01%~2%, pH adjusting agent 0.01%~5%, deionized water add to 100%.
Composition includes following constituent content when microcapsule suspension-suspendinagent agent is made：Active components A 0.5%~50% is lived
Property ingredient B0.5%~50%, dispersing agent 1%~12%, wetting agent 1%~8%, has macromolecule cyst material 2%~10%
Solvent 1%~15%, emulsifier 1%~6%, defoaming agent 0.01%~2%, thickener 0~2%, pH adjusting agent 0.01%
~5%, deionized water adds to 100%；
Wettable powder the key technical indexes of the invention：
Water dispersible granules the key technical indexes of the invention：
Suspending agent the key technical indexes of the invention：
Suspoemulsion the key technical indexes of the invention：
Aqueous emulsion the key technical indexes of the invention：
Microemulsion the key technical indexes of the invention：
Microcapsule suspending agent the key technical indexes of the invention：
Microcapsule suspension-suspendinagent agent the key technical indexes of the invention：
The advantage of the invention is that：(1) fluorine ether bacterium amide and metalaxyl, Metalaxyl-M, mandipropamid, fluazinam, pyridine
After acyl bacterium amine, zoxamide, fluopicolide, flutolanil compounding, there is apparent synergy and lasting effect；(2) grain is made
Object, legume crop, fibre crops, sugar crop, melon crop, fruits crop, dry fruit crop, hobby crop, tubers
Crop, oil crops, flower crop, medicinal crop, crop, the disease on green manure pasture crop have greater activity；(3)
Reduce pesticide usage amount, reduces residual quantity of the pesticide on crop, alleviate environmental pollution；(4) to safety of human and livestock, environment
Compatibility is good；And preparation adhesion strength enhances, resistance of rainwater washing against.
Specific embodiment
Below with reference to embodiment to further instruction of the present invention, the percentage in embodiment is weight percentage, but
The present invention is not limited thereto.
Application Example one
2 wettable powder of Examples 1 to 2
Fluorine ether bacterium amide, active constituent B, dispersing agent, wetting agent, filler are uniformly mixed in mixed cylinder, through air-flow powder
Broken machine remixes uniformly after crushing, and can be prepared by wettable powder product of the present invention, is specifically shown in Table 1.
1 Examples 1 to 2 of table, 2 each component and parts by weight
23~44 water dispersible granules of embodiment
Fluorine ether bacterium amide, active constituent B, dispersing agent, wetting agent, disintegrating agent, filler etc. are obtained through air-flow crushing together
The partial size needed adds other auxiliary agents such as binder (can add can be not added), obtains granulation materials.Item is quantified into feeding fluidisation
In bed granulating drier after granulation and drying, it can be prepared by water dispersible granules product of the present invention, be specifically shown in Table 2.
2 embodiment of table, 23~44 each component and parts by weight
45~66 suspending agent of embodiment
By dispersing agent, wetting agent, defoaming agent, thickener (can add can be not added), antifreeze (can add can be not added), by high speed
Shear-mixed is uniform, fluorine ether bacterium amide, active constituent B is added, ball milling 2~3 hours, make diameter of particle all exist in the ball mill
5 μm hereinafter, surplus is supplied with deionized water, can be prepared by suspending agent product of the present invention, specifically be shown in Table 3.
3 embodiment of table, 45~66 each component and parts by weight
67~77 suspoemulsion of embodiment
Dispersing agent, defoaming agent, thickener (can add can be not added), antifreeze (can add can be not added) are mixed by high speed shear
Uniformly, fluorine ether bacterium amide is added, in the ball mill ball milling 2~3 hours, makes diameter of particle all at 5 μm hereinafter, fluorine ether bacterium is made
Then amide suspending agents directly emulsify active constituent B, solvent, emulsifier and various auxiliary agents to suspending agent with high speed agitator
In, surplus is supplied with deionized water, and suspoemulsion product of the present invention is made, is specifically shown in Table 4.
4 embodiment of table, 67~77 each component and parts by weight
78~88 aqueous emulsion of embodiment
Fluorine ether bacterium amide, active constituent B, solvent, emulsifier are added together, make to be dissolved into homogeneous oil phase；By deionization
Water, antifreeze (can add can be not added), thickener (can add can be not added), defoaming agent mix, at uniform water phase.In high-speed stirring
It mixes down, oily phase is added in water phase, surplus is supplied with deionized water；It can be prepared by aqueous emulsion product of the present invention, be specifically shown in
Table 5.
5 embodiment of table, 78~88 each component and parts by weight
By metalaxyl, Metalaxyl-M, mandipropamid, fluazinam, Boscalid, zoxamide, fluorine pyridine acyl bacterium in table 1-5
Amine, flutolanil exchange, and novel formulation can be made.
89~91 microemulsion of embodiment
Fluorine ether bacterium amide, active constituent B, solvent, emulsifier, antifreeze (can add can be not added), defoaming agent are sufficiently mixed
At the oily phase of homogeneous transparent, it is slowly added into deionized water under stiring, forms WO emulsion, then agitated heating, makes
Rapid phase inversion at oil-in-water type, be cooled to room temperature and make up to balance, through filtering, surplus is supplied with deionized water；It can be prepared by
Microemulsion product of the present invention, is specifically shown in Table 6.
6 embodiment of table, 89~91 each component and parts by weight
Embodiment 92,93 microcapsule suspending agents
Fluorine ether bacterium amide, active constituent B, macromolecule cyst material, solvent are mixed, makes to be dissolved into homogeneous oil phase, cut
Under tangent condition, by oil be added to containing emulsifier, pH adjusting agent, dispersing agent aqueous phase solution in, surplus is mended with deionized water
Foot, two kinds of materials react in oil-water interfaces, form high score ascus wall, and it is outstanding that the well dispersed micro-capsule of the present composition is made
Floating agent product.Specifically it is shown in Table 7.
7 embodiment 92 of table, 93 each components and parts by weight
Embodiment 94,95 microcapsule suspension-suspendinagent agents
Active constituent B, macromolecule cyst material, solvent are mixed, make to be dissolved into homogeneous oil phase, by oily mutually in shearing condition
Under be added to containing emulsifier, pH adjusting agent aqueous phase solution in, well dispersed microcapsule suspending agent is made.By dispersing agent, wet
Profit agent, defoaming agent, thickener (can add can be not added) are uniformly mixed by high speed shear, fluorine ether bacterium amide are added, in the ball mill
Ball milling 2~3 hours, makes diameter of particle all at 5 μm hereinafter, suspending agent is made, suspending agent is then added to microcapsules and is suspended
In the aqueous phase solution of agent, deionized water supplies surplus, and the well dispersed microcapsule suspension-suspendinagent agent of the present composition is made and produces
Product are specifically shown in Table 8.
8 embodiment 94 of table, 95 each components and parts by weight
The embodiment of the present invention is the method combined using indoor toxicity test and field trial.First pass through indoor virulence survey
It is fixed, the synergy ratio (SR) after two kinds of medicaments compound by a certain percentage is defined, SR < 0.5 is antagonism, 0.5≤SR≤1.5
For summation action, SR > 1.5 is synergistic effect, on this basis, then carries out field trial.
Test method：After prerun determines the effective inhibition concentration range of each medicament, medicament sets 5 by active constituent content respectively
A dosage processing, if clear water compares.Reference《Farm-chemical indoor determination test rule fungicide》It carries out, speed is grown using mycelia
Rate method measures medicament to the virulence of crop germ.Colony diameter is measured with crossing method after 72h, calculates the net growth of each processing
Amount, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter -5
Mycelial growth inhibition rate is converted into probit value (y), liquor strength (μ g/mL) is converted into logarithm (x), with minimum
Square law acquires virulence regression equation (y=a+bx), and thus calculates the EC of every kind of medicament50Value.Simultaneously according to Wadley method
Two medicament different ratio synergy ratios (SR) are calculated, SR < 0.5 is antagonism, and 0.5≤SR≤1.5 are summation action,
SR > 1.5 is synergistic effect.Calculation formula is as follows：
Wherein：A, b is respectively active components A and active constituent B ratio shared in combination；
A is fluorine ether bacterium amide；B is selected from metalaxyl, Metalaxyl-M, mandipropamid, fluazinam, Boscalid, benzoyl bacterium
One of amine, fluopicolide or flutolanil kind.
Application Example two：
For trying disease：Cucumber downy mildew；Test medicine is provided by applicant.
Experimental design：Having for fluorine ether bacterium amide and metalaxyl raw medicine and the two different ratio mixture is determined by preliminary experiment
Imitate inhibition concentration range.
Toxicity test result
9 fluorine ether bacterium amide of table compounds the toxicity test analysis of results table to cucumber downy mildew with metalaxyl
As shown in Table 9, fluorine ether bacterium amide and metalaxyl are matched in 1 80~80 ︰ 1 of ︰ to the synergy ratio of cucumber downy mildew
SR is all larger than 1.5, illustrates that the two mixture in 1 ︰, 80~80 ︰, 1 range shows synergistic effect, when fluorine ether bacterium amide and first frost
For the proportion of spirit in 15 1~1 ︰ 25 of ︰, synergistic effect is more prominent, and synergy ratio is 2.25 or more；When fluorine ether bacterium amide and first
For the proportion of white spirit in 4 1~1 ︰ 14 of ︰, synergistic effect is more prominent, synergy ratio 2.35 or more, when fluorine ether bacterium amide and
Metalaxyl weight ratio is 1：Synergy ratio is maximum when 5, and synergistic effect is the most obvious.
Application Example three：
For trying disease：Downy mildew of garpe；Test medicine is provided by applicant.
Experimental design：Fluorine ether bacterium amide and Metalaxyl-M raw medicine and the two different ratio mixture are determined by preliminary experiment
Effective inhibition concentration range.
Toxicity test result
10 fluorine ether bacterium amide of table compounds the toxicity test analysis of results table to downy mildew of garpe with Metalaxyl-M
As shown in Table 10, fluorine ether bacterium amide and Metalaxyl-M are matched in 1 80~80 ︰ 1 of ︰ to the synergic ratio of downy mildew of garpe
Value SR is all larger than 1.5, illustrates that the two mixture in 1 ︰, 80~80 ︰, 1 range shows synergistic effect, when fluorine ether bacterium amide and essence
For the proportion of metalaxyl in 20 1~1 ︰ 20 of ︰, synergistic effect is more prominent, and synergy ratio is 2.35 or more；When fluorine ether bacterium amide
For proportion with Metalaxyl-M in 9 1~1 ︰ 9 of ︰, synergistic effect is more prominent, and synergy ratio is 2.40 or more, when fluorine ether bacterium acyl
Amine and Metalaxyl-M weight ratio are 1：Synergy ratio is maximum when 1, and synergistic effect is the most obvious.
Application Example four：
For trying disease：Capsicum epidemic disease；Test medicine is provided by applicant.
Experimental design：Fluorine ether bacterium amide and mandipropamid raw medicine and the two different ratio mixture are determined by preliminary experiment
Effective inhibition concentration range.
Toxicity test result
11 fluorine ether bacterium amide of table compounds the toxicity test analysis of results table to capsicum epidemic disease with mandipropamid
As shown in Table 11, fluorine ether bacterium amide and mandipropamid are matched in 1 80~80 ︰ 1 of ︰ to the synergic ratio of capsicum epidemic disease
Value SR is all larger than 1.5, both illustrates that mixture shows synergistic effect in 1 ︰, 80~80 ︰, 1 range, when fluorine ether bacterium amide and double
For the proportion of mandipropamid in 20 1~1 ︰ 20 of ︰, synergistic effect is more prominent, and synergy ratio is 2.25 or more；When fluorine ether bacterium acyl
For the proportion of amine and mandipropamid in 9 1~1 ︰ 9 of ︰, synergistic effect is more prominent, and synergy ratio is 2.35 or more, when fluorine ether
Bacterium amide and mandipropamid weight ratio are 1：Synergy ratio is maximum when 1, and synergistic effect is the most obvious.
Application Example five：
For trying disease：Potato blight；Test medicine is provided by applicant.
Experimental design：Having for fluorine ether bacterium amide and fluazinam raw medicine and the two different ratio mixture is determined by preliminary experiment
Imitate inhibition concentration range.
Toxicity test result
12 fluorine ether bacterium amide of table compounds the toxicity test analysis of results table to potato blight with fluazinam
As shown in Table 12, fluorine ether bacterium amide and fluazinam are matched in 1 80~80 ︰ 1 of ︰ to the synergy ratio of potato blight
SR is all larger than 1.5, illustrates that the two mixture in 1 ︰, 80~80 ︰, 1 range shows synergistic effect, when fluorine ether bacterium amide and fluorine pyridine
For the proportion of amine in 20 1~1 ︰ 20 of ︰, synergistic effect is more prominent, and synergy ratio is 2.25 or more；When fluorine ether bacterium amide and fluorine
Pyridine amine weight ratio is 1：Synergy ratio is maximum when 2, and synergistic effect is the most obvious.
Application Example six：
For trying disease：Grape grey mould；Test medicine is provided by applicant.
Experimental design：Fluorine ether bacterium amide and Boscalid raw medicine and the two different ratio mixture are determined by preliminary experiment
Effective inhibition concentration range.
Toxicity test result
13 fluorine ether bacterium amide of table compounds the toxicity test analysis of results table to grape grey mould with Boscalid
As shown in Table 13, fluorine ether bacterium amide and Boscalid are matched in 1 80~80 ︰ 1 of ︰ to the synergic ratio of grape grey mould
Value SR is all larger than 1.5, illustrates that the two mixture in 1 ︰, 80~80 ︰, 1 range shows synergistic effect, when fluorine ether bacterium amide and pyridine
For the proportion of acyl bacterium amine in 20 1~1 ︰ 20 of ︰, synergistic effect is more prominent, and synergy ratio is 2.25 or more；When fluorine ether bacterium amide
It is 1 with Boscalid weight ratio：Synergy ratio is maximum when 2, and synergistic effect is the most obvious.
Application Example seven：
For trying disease：Powdery mildew of cucumber；Test medicine is provided by applicant.
Experimental design：Fluorine ether bacterium amide and zoxamide raw medicine and the two different ratio mixture are determined by preliminary experiment
Effective inhibition concentration range.
Toxicity test result
14 fluorine ether bacterium amide of table compounds the toxicity test analysis of results table to powdery mildew of cucumber with zoxamide
As shown in Table 14, fluorine ether bacterium amide and zoxamide are matched in 1 80~80 ︰ 1 of ︰ to the synergic ratio of powdery mildew of cucumber
Value SR is all larger than 1.5, illustrates that the two mixture in 1 ︰, 80~80 ︰, 1 range shows synergistic effect, when fluorine ether bacterium amide and benzene
For the proportion of acyl bacterium amine in 20 1~1 ︰ 20 of ︰, synergistic effect is more prominent, and synergy ratio is 2.25 or more；When fluorine ether bacterium amide
It is 2 with zoxamide weight ratio：Synergy ratio is maximum when 3, and synergistic effect is the most obvious.
Application Example eight：
For trying disease：Rice blast；Test medicine is provided by applicant.
Experimental design：Fluorine ether bacterium amide and fluopicolide raw medicine and the two different ratio mixture are determined by preliminary experiment
Effective inhibition concentration range.
Toxicity test result
15 fluorine ether bacterium amide of table compounds the toxicity test analysis of results table to rice blast with fluopicolide
As shown in Table 15, fluorine ether bacterium amide and fluopicolide match the synergy in 1 80~80 ︰ 1 of ︰ to rice blast
Ratio SR is all larger than 1.5, both illustrates that mixture shows synergistic effect in 1 ︰, 80~80 ︰, 1 range, when fluorine ether bacterium amide with
For the proportion of fluopicolide in 20 1~1 ︰ 20 of ︰, synergistic effect is more prominent, and synergy ratio is 2.30 or more；When fluorine ether bacterium
Amide and fluopicolide weight ratio are 1：Synergy ratio is maximum when 2, and synergistic effect is the most obvious.
Application Example nine：
For trying disease：Rice sheath blight disease；Test medicine is provided by applicant.
Experimental design：Effective suppression of flutolanil and flutolanil raw medicine and the two different ratio mixture is determined by preliminary experiment
Concentration range processed.
Toxicity test result
16 flutolanil of table compounds the toxicity test analysis of results table to rice sheath blight disease with flutolanil
As shown in Table 16, flutolanil matches equal to the synergy ratio SR of rice sheath blight disease in 1 80~80 ︰ 1 of ︰ with flutolanil
Greater than 1.5, illustrate that the two mixture in 1 ︰, 80~80 ︰, 1 range shows synergistic effect, when the proportion of flutolanil and flutolanil
In 15 1~1 ︰ 25 of ︰, synergistic effect is more prominent, and synergy ratio is 2.25 or more；When flutolanil and flutolanil weight ratio are
1：Synergy ratio is maximum when 3, and synergistic effect is the most obvious.
Through applicant test the optimum ratio of discovery fluorine ether bacterium amide and metalaxyl or flutolanil be 15 ︰ 1,14 ︰ 1,13 ︰ 1,
12 ︰ 1,11 ︰ 1,10 ︰ 1,9 ︰ 1,8 ︰ 1,7 ︰ 1,6 ︰ 1,5 ︰ 1,4 ︰ 1,3 ︰ 1,2 ︰ 1,1 ︰ 1,1 ︰ 2,1 ︰ 3,1 ︰ 4,1 ︰ 5,1 ︰ 6,1 ︰ 7,1 ︰
8,1 ︰ 9,1 ︰ 10,1 ︰ 11,1 ︰ 12,1 ︰ 13,1 ︰ 14,1 ︰ 15,1 ︰ 16,1 ︰ 17,1 ︰ 18,1 ︰ 19,1 ︰ 20,1 ︰ 21,1 ︰ 22,1 ︰ 23,
1 ︰ 24,1 ︰ 25, fluorine ether bacterium amide and Metalaxyl-M, mandipropamid, fluazinam, Boscalid, zoxamide or fluorine pyridine acyl bacterium
The optimum ratio of amine be 20 ︰ 1,19 ︰ 1,18 ︰ 1,17 ︰ 1,16 ︰ 1,15 ︰ 1,14 ︰ 1,13 ︰ 1,12 ︰ 1,11 ︰ 1,10 ︰ 1,9 ︰ 1,8 ︰ 1,
7 ︰ 1,6 ︰ 1,5 ︰ 1,4 ︰ 1,3 ︰ 1,2 ︰ 1,1 ︰ 1,1 ︰ 2,1 ︰ 3,1 ︰ 4,1 ︰ 5,1 ︰ 6,1 ︰ 7,1 ︰ 8,1 ︰ 9,1 ︰ 10,1 ︰ 11,1 ︰ 12,1 ︰
13,1 ︰ 14,1 ︰ 15,1 ︰ 16,1 ︰ 17,1 ︰ 18,1 ︰ 19,1 ︰, 20 synergistic effect are more obvious.
It is found through experiment that：Fluorine ether bacterium amide compounded with active constituent B after in various crop downy mildew, epidemic disease, rust,
Balck shank, foot rot, powdery mildew, root rot, samping off, seedling rot, clubroot, gray mold, disk obstruct mould, brown spot, rice blast
Or the prevention and treatment of banded sclerotial blight has apparent synergistic effect, synergy ratio SR is all larger than 1.5.
Effect experiment part：Test medicine is researched and developed by applicant, is provided, 50% fluorine ether bacterium amide wettable powder of comparison medicament
Agent (autogamy), 25% metalaxyl wettable powder (commercially available), 350g/l Metalaxyl-M seed treatment emulsion (commercially available), 23.4% pair
Mandipropamid suspending agent (commercially available), 500g/l fluazinam suspending agent (autogamy), 50% Boscalid water dispersible granules (commercially available),
24% zoxamide suspending agent (commercially available), 25% fluopicolide suspending agent (autogamy), 20% flutolanil wettable powder (city
Purchase).
Ten fluorine ether bacterium amide of Application Example and active constituent B and its compound prevention and treatment cucumber downy mildew pharmacodynamic test.This examination
It tests and is arranged in Xianyang, Shanxi province suburban area, cucumber downy mildew disease index is investigated before medicine, is administered in the early stages of disease, after application
3 days, 10 days, 20 days investigation disease indexes and calculate preventive effect.Test result is as follows：
17 fluorine ether bacterium amide of table and active constituent B and its compound prevention and treatment cucumber downy mildew pharmacodynamic test
As can be seen from Table 17, cucumber downy mildew can be effectively prevented after fluorine ether bacterium amide is compounded with active constituent B, through applying
People, which tests after discovery fluorine ether bacterium amide is compounded with active constituent B, can also effectively prevent powdery mildew of cucumber or gray mold of cucumber, prevent
It controls effect and is above 97%, better than the preventive effect of single dose, and preventive effect phase is long.To target crop without bad shadow in test scope of medication
It rings.
Ten monofluoro-ether bacterium amide of Application Example and active constituent B and its compound prevention and treatment tomato blight pharmacodynamic test.This examination
It tests and is arranged in Xian District, Shanxi Province suburban area, tomato blight disease index is investigated before medicine, is administered in the early stages of disease, 3 after application
It, 10 days, 20 days investigation disease indexes and calculate preventive effect.Test result is as follows：
18 fluorine ether bacterium amide of table and active constituent B and its compound prevention and treatment tomato blight pharmacodynamic test
As can be seen from Table 18, tomato blight, control efficiency can be effectively prevented after fluorine ether bacterium amide is compounded with active constituent B
It is above 97%, better than the preventive effect of single dose, and preventive effect phase is long.It has no adverse effects in test scope of medication to target crop.
Ten difluoro ether bacterium amide of Application Example and active constituent B and its compound prevention and treatment rice blast pharmacodynamic test.This
Test arrangement investigates rice blast disease index before Shaanxi Province's Hanzhong City, medicine, is administered in the early stages of disease, 3 after application
It, 10 days, 20 days investigation disease indexes and calculate preventive effect.Test result is as follows：
19 fluorine ether bacterium amide of table and active constituent B and its compound prevention and treatment rice blast pharmacodynamic test
As can be seen from Table 19, rice blast can be effectively prevented after fluorine ether bacterium amide is compounded with active constituent B, through applying
People, which tests after discovery fluorine ether bacterium amide is compounded with active constituent B, can also effectively prevent rice samping off, rice sheath blight disease or water
Seedling blight of rice disease, control efficiency are above 97%, and better than the preventive effect of single dose, and preventive effect phase is long.To target in test scope of medication
Crop has no adverse effects.
Ten trifluoro bacterium amide of Application Example and active constituent B and its compound prevention and treatment grape grey mould pharmacodynamic test.This
Test arrangement investigates grape grey mould disease index before Shaanxi Province Weinan City Dali County, medicine, is administered, applies in the early stages of disease
3 days after medicine, 10 days, 20 days investigation disease indexes and calculate preventive effect.Test result is as follows：
20 fluorine ether bacterium amide of table and active constituent B and its compound prevention and treatment grape grey mould pharmacodynamic test
As can be seen from Table 20, grape grey mould can be effectively prevented after fluorine ether bacterium amide is compounded with active constituent B, through applying
People, which tests after discovery fluorine ether bacterium amide is compounded with active constituent B, can also effectively prevent downy mildew of garpe or uncinula necator, prevent
It controls effect and is above 97%, better than the preventive effect of single dose, and preventive effect phase is long.To target crop without bad shadow in test scope of medication
It rings.
The test by different places throughout the country obtains afterwards, fluorine ether bacterium amide compounded with active constituent B after to a variety of
Downy mildew, epidemic disease on crop, rust, balck shank, foot rot, powdery mildew, root rot, samping off, seedling rot, clubroot, ash
Mildew, disk obstruct the preventive effect of the Common Diseases such as mould, brown spot, rice blast or banded sclerotial blight 95% or more, are better than single dose preventive effect, increase
Effect effect is obvious.
Claims (6)
1. a kind of combination sterilization composition of fluorine-containing ether bacterium amide, effective active composition is active components A and active constituent B,
It is characterized in that：Active components A and active constituent B weight ratio are 1 ︰, 80 ~ 80 ︰ 1, and the active components A is selected from fluorine ether bacterium amide,
Active constituent B in metalaxyl, Metalaxyl-M, fluazinam, Boscalid, zoxamide, fluopicolide or flutolanil it
It is a kind of.
2. the combination sterilization composition of fluorine-containing ether bacterium amide according to claim 1, it is characterised in that：Active components A with
The weight ratio of active constituent B is 1 ︰, 40 ~ 40 ︰ 1.
3. the combination sterilization composition of fluorine-containing ether bacterium amide according to claim 2, it is characterised in that：
The weight ratio of fluorine ether bacterium amide and metalaxyl is 15:1~1:25；
The weight ratio of fluorine ether bacterium amide and Metalaxyl-M is 20:1~1:20；
The weight ratio of fluorine ether bacterium amide and fluazinam is 20:1~1:20；
The weight ratio of fluorine ether bacterium amide and Boscalid is 20:1~1:20；
The weight ratio of fluorine ether bacterium amide and zoxamide is 20:1~1:20；
The weight ratio of fluorine ether bacterium amide and fluopicolide is 20:1~1:20；
The weight ratio of fluorine ether bacterium amide and flutolanil is 15:1~1:25.
4. the combination sterilization composition of fluorine-containing ether bacterium amide according to any one of claim 1 to 3, it is characterised in that：
Wettable powder, water dispersible granules, suspending agent, suspoemulsion, aqueous emulsion, microemulsion, microcapsule suspending agent or micro-capsule is made in composition
Suspension-suspending agent.
5. the use that the combination sterilization composition of fluorine-containing ether bacterium amide according to claim 4 is used to prevent and treat disease on crops
On the way.
6. purposes according to claim 5, it is characterised in that：The disease be downy mildew, epidemic disease, rust, balck shank,
Foot rot, powdery mildew, root rot, samping off, seedling rot, clubroot, gray mold, the mould, brown spot of disk stalk, rice blast or line are withered
Disease.
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Effective date of registration: 20191226 Address after: 715500 Pucheng County High-tech Industrial Development Zone, Weinan City, Shaanxi Province Applicant after: Shaanxi Mei Bang Pharmaceutical Group Limited by Share Ltd Address before: 715500 middle section of North Ring Road, Pucheng County, Shaanxi, Weinan Applicant before: Zhang Tong |
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