CN104412981B - A kind of bactericidal composition of fluorine-containing ether bacterium amide and methoxy acrylic - Google Patents
A kind of bactericidal composition of fluorine-containing ether bacterium amide and methoxy acrylic Download PDFInfo
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- CN104412981B CN104412981B CN201310403719.5A CN201310403719A CN104412981B CN 104412981 B CN104412981 B CN 104412981B CN 201310403719 A CN201310403719 A CN 201310403719A CN 104412981 B CN104412981 B CN 104412981B
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Abstract
The invention discloses a kind of bactericidal compositions of fluorine-containing ether bacterium amide and methoxy acrylic, and containing active components A and active constituent B, wherein active components A is selected from fluorine ether bacterium amide, and active constituent B is selected from any one following compound：Kresoxim-methyl, Fluoxastrobin, trifloxystrobin, pyraclostrobin, dimoxystrobin, fluoxastrobin, ZEN 90160, Enestroburin, pyraoxystrobin, and active components A and the weight ratio of active constituent B are 1：80~80：1.The present composition has synergistic effect to the multiple diseases for endangering agricultural production, reduces pesticide usage amount, reduces residual quantity of the pesticide on crop, alleviate environmental pollution, to safety of human and livestock, Environmental compatibility is good, and disease is not likely to produce drug resistance.
Description
Technical field
The invention belongs to technical field of pesticide, are related to a kind of sterilization group of fluorine-containing ether bacterium amide and methoxy acrylic
Close application of the object on corps diseases.
Background technology
Fluorine ether bacterium amide (LH-2010A) selective fungicide fluopicolide more similar than structure has wider array of fungicidal spectrum.
Fluorine ether bacterium amide is to the bacteriostatic activity highest of cotton standing dead rhizoctonia and botrytis cinerea, to Phytophthora capsici and potato late blight
Germ has higher antibacterial work, and fluorine ether bacterium amide is apparent to cotton standing dead rhizoctonia bacteriostasis, can significantly inhibit its sclerotium
Generation and mycelium morphology factor, make mycelia branch increase, shorten, is thicker；Fluorine ether bacterium amide has various plants pathogen higher
Bacteriostatic activity, and can obviously inhibit the multinomial physical signs of cotton standing dead rhizoctonia.
Kresoxim-methyl, Fluoxastrobin, trifloxystrobin, pyraclostrobin, dimoxystrobin, fluoxastrobin, ZEN 90160, Enestroburin or azoles
Bacterium ester belongs to the bactericidal composition of methoxy acrylic, is widely used in the disease of crops.
However, in the real process of agricultural production, the problem of controlling disease most easily produces is the production of disease drug resistance
It is raw.Different cultivars ingredient is compounded, and is to prevent the very common method of resistance disease.Heterogeneity is compounded, according to reality
Application effect, to judge that certain compounding is synergy, adduction or antagonism.In most cases, the compounding effect of pesticide
All it is additive effect, really has the compounding of synergistic effect seldom, especially synergistic effect is clearly, co-toxicity coefficient is very high answers
With just less.Studied by inventor, find by fluorine ether bacterium amide and kresoxim-methyl, Fluoxastrobin, trifloxystrobin, pyraclostrobin,
Good synergistic effect can be generated after dimoxystrobin, fluoxastrobin, ZEN 90160, Enestroburin or pyraoxystrobin compounding, and about
Fluorine ether bacterium amide and kresoxim-methyl, Fluoxastrobin, trifloxystrobin, pyraclostrobin, dimoxystrobin, fluoxastrobin, ZEN 90160, Enestroburin
Or the relevant report of pyraoxystrobin compounding not yet discloses.
Invention content
There is synergistic function, the fluorine-containing ether bacterium acyl that use cost is low, preventive effect is good the purpose of the present invention is to propose to a kind of
The bactericidal composition of amine and methoxy acrylic.
The bactericidal composition of fluorine-containing ether bacterium amide and methoxy acrylic proposed by the present invention contain active components A with
Active constituent B, active components A are 1 with active constituent B weight ratios：80~80：1, the active components A is selected from fluorine ether bacterium acyl
Amine, active constituent B are selected from kresoxim-methyl, Fluoxastrobin, trifloxystrobin, pyraclostrobin, dimoxystrobin, fluoxastrobin, ZEN 90160, alkene oxime
One of bacterium ester or pyraoxystrobin are planted, and active components A is 1 with the preferred weight ratios of active constituent B：60~60：1；More preferably fluorine
The weight ratio of ether bacterium amide and kresoxim-methyl is 1：25~20：1, the weight ratio of fluorine ether bacterium amide and Fluoxastrobin is 1：30~25：1,
The weight ratio of fluorine ether bacterium amide and trifloxystrobin is 1：25~20：1, the weight ratio of fluorine ether bacterium amide and pyraclostrobin is 1：30~
30：1, the weight ratio of fluorine ether bacterium amide and dimoxystrobin is 1：30~30：1, the weight ratio of fluorine ether bacterium amide and fluoxastrobin is 1：
25~20：1, the weight ratio of fluorine ether bacterium amide and ZEN 90160 is 1：25~20：1, the weight of fluorine ether bacterium amide and Enestroburin
Than being 1：25~20：1, the weight ratio of fluorine ether bacterium amide and pyraoxystrobin is 1：20~25：1；Most preferably fluorine ether bacterium amide and ether
The weight ratio of bacterium ester is 1：9~4：1, the weight ratio of fluorine ether bacterium amide and Fluoxastrobin is 1：11~4：1, fluorine ether bacterium amide and oxime bacterium
The weight ratio of ester is 1：9~4：1, the weight ratio of fluorine ether bacterium amide and pyraclostrobin is 1：11~11：1, fluorine ether bacterium amide with
The weight ratio of dimoxystrobin is 1：11~11：1, the weight ratio of fluorine ether bacterium amide and fluoxastrobin is 1：9~4：1, fluorine ether bacterium amide
Weight ratio with ZEN 90160 is 1：11~5：1, the weight ratio of fluorine ether bacterium amide and Enestroburin is 1：9~4：1, fluorine ether bacterium acyl
The weight ratio of amine and pyraoxystrobin is 1：9~6：1.
The bactericidal composition of fluorine-containing ether bacterium amide and methoxy acrylic of the present invention is for preventing crops
The purposes of upper disease, the crops include cereal crops, legume crop, fibre crops, sugar crop, melon crop, water
Orchard crop, dry fruit crop, hobby crop, root crop, oil crops, flower crop, medicinal crop, crop,
Green manure pasture crop；The disease includes rust, epidemic disease, sclerotiniose, gray mold, downy mildew, peronospora tabacina, spot fallen leaves
Disease, powdery mildew, scab, rice blast, banded sclerotial blight, shot hole, anthracnose, brown spot, leaf spot, leaf blight, spike rot, grain husk are withered
Disease, net blotch, moire disease.
Active components A, the weight ratio of active constituent B are 1：80~80：1.The weight hundred of active component in usual composition
Divide content for the 0.1%~90% of total weight, preferably 5%~70%.According to different preparation types, active component content
Range is different.In general, liquid preparation contains by weight 1%~70% active material, preferably 5%~50%；
Solid pharmaceutical preparation contains by weight 5%~70% active material, preferably 10%~70%.
The present invention bactericidal composition at least contain a kind of surfactant, in favor of application when active component in water
Dispersion.Surface-active contents are the 5%~30% of total formulation weight, and surplus is solid or liquid diluent.
The bactericidal composition of the present invention can used before through dilution or directly by user.Its preparation can be by usual
Processing method known in those skilled in the art prepare, i.e., after active material being mixed with liquid flux or solid carrier,
Add one kind in surfactant such as dispersant, stabilizer, wetting agent, binder, antifoaming agent, disintegrant, antifreeze
Or it is several.
The bactericidal composition of the present invention, can be processed into any dosage form pesticide-acceptable, wherein more preferably on demand
Dosage form be that wettable powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent, micro-capsule are outstanding
Floating-suspending agent, can also be made granule, seed coat agent, suspension seed-coating agent, ultra low volume liquids.
Composition includes following constituent content when wettable powder is made：Active components A 1%~80%, active constituent
B1%~80%, dispersant 2%~10%, wetting agent 2%~10%, filler surplus.
Composition includes following constituent content when water dispersible granules are made：Active components A 1%~80%, active constituent
B1%~80%, dispersant 3%~12%, wetting agent 1%~8%, disintegrant 1%~10%, binder 0~8%, more than filler
Amount.
Composition includes following constituent content when suspending agent is made：Active components A 0.5%~50%, active constituent
B0.5%~50%, dispersant 2%~10%, wetting agent 2%~10%, antifoaming agent 0.01%~2%, thickener 0~2%,
Antifreeze 0~8%, deionized water add to 100%.
Composition includes following constituent content when suspension emulsion is made：Active components A 0.5%~50%, active constituent
B0.5%~50%, dispersant 2%~10%, antifoaming agent 0.01%~2%, solvent 1%~15%, thickener 0~2%, breast
Agent 2%~12%, antifreeze 0~8%, deionized water add to 100%.
Composition includes following constituent content when aqueous emulsion is made：Active components A 0.5%~50%, active constituent
B0.5%~50%, solvent 1%~30%, emulsifier 1%~15%, antifreeze 0~8%, thickener 0~2%, antifoaming agent
0.01%~2%, deionized water supplies surplus.
Composition includes following component and content when microemulsion is made：Active components A 0.5%~50%, active constituent
B0.5%~50%, solvent 1%~10%, antifreeze 0~8%, antifoaming agent 0.01%~2%, is gone emulsifier 3%~25%
Ionized water adds to 100%.
Composition includes following constituent content when microcapsule suspending agent is made：Active components A 0.5%~50%, active constituent
B0.5%~50%, macromolecule cyst material 2%~10%, dispersant 1%~10%, organic solvent 1%~10%, emulsifier
1%~7%, antifoaming agent 0.01%~2%, pH adjusting agent 0.01%~5%, deionized water add to 100%.
Composition includes following constituent content when microcapsule suspension-suspendinagent agent is made：Active components A 0.5%~50%, activity
It is ingredient B0.5%~50%, macromolecule cyst material 2%~10%, dispersant 1%~12%, wetting agent 1%~8%, organic
Solvent 1%~15%, emulsifier 1%~6%, antifoaming agent 0.01%~2%, thickener 0~2%, pH adjusting agent 0.01%~
5%, deionized water adds to 100%.
The wettable powder the key technical indexes of the present invention：
The water dispersible granules the key technical indexes of the present invention：
The suspending agent the key technical indexes of the present invention：
The suspension emulsion the key technical indexes of the present invention：
The aqueous emulsion the key technical indexes of the present invention：
The microemulsion the key technical indexes of the present invention：
The microcapsule suspending agent the key technical indexes of the present invention：
The microcapsule suspension-suspendinagent agent the key technical indexes of the present invention：
The advantage of the invention is that：
(1) fluorine ether bacterium amide and kresoxim-methyl, Fluoxastrobin, trifloxystrobin, pyraclostrobin, dimoxystrobin, fluoxastrobin, pyridine oxygen bacterium
After ester, Enestroburin, pyraoxystrobin compounding, there is apparent synergy and lasting effect；(2) to cereal crops, legume crop, fiber
Crop, sugar crop, melon crop, fruits crop, dry fruit crop, hobby crop, root crop, oil crops, flower
Grass crop, medicinal crop, crop, disease has greater activity on green manure pasture crop；(3) reduce pesticide usage amount,
Residual quantity of the pesticide on crop is reduced, environmental pollution is alleviated；(4) to safety of human and livestock, Environmental compatibility is good；And preparation
Adhesion strength enhances, resistance of rainwater washing against.
Specific implementation mode
With reference to embodiment to further instruction of the present invention, the percentage in embodiment is weight percentage, but
The present invention is not limited thereto.
Application Example one
1~15 wettable powder of embodiment
Fluorine ether bacterium amide, active constituent B, dispersant, wetting agent, filler are uniformly mixed in mixed cylinder, through air-flow powder
Broken machine remixes uniformly after crushing, you can wettable powder product of the present invention is made, is specifically shown in Table 1.
1 embodiment of table, 1~15 each component and parts by weight
16~30 water dispersible granules of embodiment
Fluorine ether bacterium amide, active constituent B, dispersant, wetting agent, disintegrant, filler etc. are obtained through air-flow crushing together
The grain size needed adds other auxiliary agents such as binder (can add can be not added with), obtains granulation materials.Item is quantified into feeding fluidisation
In bed granulating drier after granulation and drying, you can water dispersible granules product of the present invention is made, is specifically shown in Table 2.
2 embodiment of table, 16~30 each component and parts by weight
31~45 suspending agent of embodiment
By dispersant, wetting agent, antifoaming agent, thickener (can add can be not added with), antifreeze (can add can be not added with), by high speed
Shear-mixed is uniform, fluorine ether bacterium amide, active constituent B is added, ball milling 2~3 hours, make diameter of particle all exist in the ball mill
5 μm hereinafter, surplus is supplied with deionized water, you can suspending agent product of the present invention is made, is specifically shown in Table 3.
3 embodiment of table, 31~45 each component and parts by weight
46~48 suspension emulsion of embodiment
Dispersant, antifoaming agent, thickener (can add can be not added with), antifreeze (can add can be not added with) are mixed by high speed shear
Uniformly, fluorine ether bacterium amide is added, in the ball mill ball milling 2~3 hours, makes diameter of particle all at 5 μm hereinafter, fluorine ether bacterium is made
Then active constituent B, solvent, emulsifier and various auxiliary agents are directly emulsified with high speed agitator and arrive suspending agent by amide suspending agents
In, surplus is supplied with deionized water, and suspension emulsion product of the present invention is made, and tool is originally shown in Table 4.
4 embodiment of table, 46~48 each group and parts by weight
49~60 aqueous emulsion of embodiment
Fluorine ether bacterium amide, active constituent B, solvent, emulsifier are added together, make to be dissolved into homogeneous oil phase；By deionization
Water, antifreeze (can add can be not added with), thickener (can add can be not added with), antifoaming agent mix, at uniform water phase.In high-speed stirring
It mixes down, oil phase is added in water phase, surplus is supplied with deionized water；Aqueous emulsion product of the present invention is can be prepared by, is specifically shown in
Table 5.
5 embodiment of table, 49~60 each component and parts by weight
By kresoxim-methyl, Fluoxastrobin, trifloxystrobin, pyraclostrobin, dimoxystrobin, fluorine kresoxim-methyl, ZEN 90160, alkene in table 1~5
Trifloxystrobin, pyraoxystrobin are exchanged, and novel formulation can be made.
61~63 microemulsion of embodiment
Fluorine ether bacterium amide, active constituent B are dissolved in the homogenizer equipped with solvent, by emulsifier, antifreeze, (can add can
Be not added with), antifoaming agent be added in the homogenizer equipped with above-mentioned solution, surplus give after being supplied with deionized water strongly mixing and it is even
Change, finally obtains the transparent microemulsion product of the present invention of clear appearance.Specifically it is shown in Table 6.
6 embodiment of table, 61~63 each component and content
Embodiment 64,65 microcapsule suspending agents
Fluorine ether bacterium amide, active constituent B, macromolecule cyst material, solvent are mixed, makes to be dissolved into homogeneous oil phase, cut
Under tangent condition, by oil phase be added to containing emulsifier, pH adjusting agent, dispersant aqueous phase solution in, surplus is mended with deionized water
Foot, two kinds of materials react in oil-water interfaces, form high score ascus wall, and it is outstanding that the well dispersed micro-capsule of the present composition is made
Floating agent product.Specifically it is shown in Table 7.
7 embodiment 64 of table, 65 each components and parts by weight
Embodiment 66,67 microcapsule suspension-suspendinagent agents
Active constituent B, macromolecule cyst material, solvent are mixed, make to be dissolved into homogeneous oil phase, by oil phase in shearing condition
Under be added to containing emulsifier, pH adjusting agent aqueous phase solution in, well dispersed microcapsule suspending agent is made.By dispersant, wet
Profit agent, antifoaming agent, thickener (can add can be not added with) are uniformly mixed by high speed shear, fluorine ether bacterium amide are added, in the ball mill
Ball milling 2~3 hours makes diameter of particle all at 5 μm hereinafter, suspending agent is made, suspending agent is then added to microcapsules and is suspended
In the aqueous phase solution of agent, deionized water supplies surplus, and the well dispersed microcapsule suspension-suspendinagent agent production of the present composition is made
Product are specifically shown in Table 8.
8 embodiment 66 of table, 67 each components and parts by weight
The embodiment of the present invention is the method being combined using Toxicity Determination and field trial.First pass through indoor virulence survey
It is fixed, define the co-toxicity coefficient (CTC) after two kinds of medicaments compound by a certain percentage, CTC<70 be antagonism, 70≤CTC≤120
For summation action, CTC>120 be synergistic effect, on this basis, then carries out field trial.
Test method：The mother liquor of each mixed agent is diluted to five series concentrations respectively when experiment, is respectively placed in beaker
It is spare.Using the first leaching leaf method that is followed by bacterium, by not in contact with the blade of the same size of any medicament in the liquid configured
It takes out, naturally dry, is put into bacteria box after immersion 5s, then connect for the young bacterium of examination, raised under the conditions of 25 DEG C, often handle 3
Secondary repetition, it is 50 often to repeat examination bacterium number used, while setting blank control, checks dead bacterium number in 72h, calculates the death rate and correction
The death rate acquires virulence regression equation and calculates LC50Value.If compareing the death rate is more than 10%, it is considered as invalid experiment.It calculates public
Formula is as follows：
Disease corrected mortality is converted into probit value (y), concentration for the treatment of (μ g/ml) is converted into logarithm (x), with minimum
Square law obtains virulence regression equation, and thus calculates the value of each medicament, and calculating total poison according to the abundant equations of Sun Yun is
Number CTC.Calculation formula is following (using fluorine ether bacterium amide as standard agent, toxicity index 100)：
TI × P of the theoretical toxicity index (TTI) of M=fluorine ether bacterium amideFluorine ether bacterium amide+The TI of effective active composition B ×
PEffective active compositionB
In formula：M is the mixture of different ratio
PEffective active compositionB is effective active composition B shared ratios in the composition
PFluorine ether bacterium amideFor fluorine ether bacterium amide shared ratio in the composition
B is selected from kresoxim-methyl, Fluoxastrobin, trifloxystrobin, pyraclostrobin, dimoxystrobin, fluoxastrobin, ZEN 90160, alkene oxime bacterium
One of ester, pyraoxystrobin are planted.
Application Example two：
For trying disease：Powdery mildew of cucumber；Test medicine is provided by applicant；Experimental design：It is determined by pilot study
Fluorine ether bacterium amide and kresoxim-methyl active compound and effective lethasl concentration range of the two different ratio mixture.
Toxicity test result
9 fluorine ether bacterium amide of table compounds the toxicity test analysis of results table to powdery mildew of cucumber with kresoxim-methyl
As shown in Table 9, fluorine ether bacterium amide is matched with kresoxim-methyl 1：80~80：To the synergy ratio of powdery mildew of cucumber when 1
SR is all higher than 1.5, illustrates the two 1：80~80：Mixture shows synergistic effect in 1 range, when fluorine ether bacterium amide and ether bacterium
The proportioning of ester is 1：25~20：When 1, synergistic effect is more prominent, and synergy ratio is 2.25 or more；When fluorine ether bacterium amide and ether
The proportioning of bacterium ester is 1：9~4：When 1, synergistic effect is more prominent, and synergy ratio is 2.40 or more.It tests and finds through applicant
The optimum ratio of fluorine ether bacterium amide and kresoxim-methyl is 20：1、15：1、10：1、8：1、7：1、6：1、5：1、4：1、3：1、2：1、1：1、
2：3、1：2、1：3、1：4、1：5、1：6、1：8、1：10、1：15、1：20、1：25, especially when fluorine ether bacterium amide and kresoxim-methyl weight
Amount is than being 2：Synergy ratio is maximum when 3, and synergistic effect is the most apparent.
Application Example three：
For trying disease：Downy mildew of garpe；Test medicine is provided by applicant；Experimental design：It is determined by pilot study
Fluorine ether bacterium amide and Fluoxastrobin active compound or effective inhibition concentration range of the two different ratio mixture.
Toxicity test result
10 fluorine ether bacterium amide of table is with azoxystrobin compound to the toxicity test analysis of results table of downy mildew of garpe
As shown in Table 10, fluorine ether bacterium amide is matched with Fluoxastrobin 1：80~80：To the synergy ratio of downy mildew of garpe when 1
SR is all higher than 1.5, illustrates the two 1：80~80：Mixture shows synergistic effect in 1 range, when fluorine ether bacterium amide and phonetic bacterium
The proportioning of ester is 1：30~25：When 1, synergistic effect becomes apparent protrusion, and synergy ratio is 2.25 or more；When fluorine ether bacterium amide
Proportioning with Fluoxastrobin is 1：11~4：When 1, synergistic effect becomes apparent protrusion, and synergy ratio is 2.40 or more.Through application
People, which tests, finds that the optimum ratio of fluorine ether bacterium amide and Fluoxastrobin is 25：1、20：1、15：1、10：1、8：1、6：1、5：1、4：1、
3：1、2：1、1：1、1：2、1：3、1：4、1：5、1：6、1：7、1：8、1：9、1：10、1；11、1：12、1：15、1：20、1：30, especially
It is when fluorine ether bacterium amide and Fluoxastrobin weight ratio are 1：Synergy ratio is maximum when 3, and synergistic effect is the most apparent.
Application Example four：
For trying disease：Wheat rust；Test medicine is provided by applicant.Experimental design：Fluorine is determined by pilot study
Ether bacterium amide and trifloxystrobin active compound or effective inhibition concentration range of the two different ratio mixture.
Toxicity test result
11 fluorine ether bacterium amide of table compounds the toxicity test analysis of results table to wheat rust with trifloxystrobin
As shown in Table 11, fluorine ether bacterium amide is matched with trifloxystrobin 1：80~80：To the synergy ratio SR of wheat rust when 1
1.5 are all higher than, illustrates the two 1：80~80：Mixture shows synergistic effect in 1 range, when fluorine ether bacterium amide and trifloxystrobin
Proportioning 1：25~20：When 1, synergistic effect becomes apparent protrusion, and synergy ratio is 2.20 or more；When fluorine ether bacterium amide with
The proportioning of trifloxystrobin is 1：9~4：When 1, synergistic effect becomes apparent protrusion, and synergy ratio is 2.40 or more.It is tried through applicant
The optimum ratio for issuing after examination and approval existing fluorine ether bacterium amide and trifloxystrobin is 20：1、15：1、10：1、8：1、7：1、6：1、5：1、4：1、3：1、2：
1、1：1、2：3、1：2、1：3、1：4、1：5、1：6、1：8、1：10、1：15、1：20、1：25, especially when fluorine ether bacterium amide and oxime
Bacterium ester weight ratio is 2：Synergy ratio is maximum when 3, and synergistic effect is the most apparent.
Application Example five：
For trying disease：Powdery mildew of cucumber；Test medicine is provided by applicant；Experimental design：It is determined by pilot study
Fluorine ether bacterium amide and pyraclostrobin active compound or effective inhibition concentration range of the two different ratio mixture.
Toxicity test result
12 fluorine ether bacterium amide of table compounds the toxicity test analysis of results table to powdery mildew of cucumber with pyraclostrobin
As shown in Table 12, fluorine ether bacterium amide is matched with pyraclostrobin 1：80~80：To the synergy of powdery mildew of cucumber when 1
Ratio SR is all higher than 1.5, illustrates the two 1：80~80：Mixture shows synergistic effect in 1 range, when fluorine ether bacterium amide with
The proportioning of pyraclostrobin is 1：30~30：When 1, synergistic effect becomes apparent protrusion, and synergy ratio is 2.25 or more, especially
It is when fluorine ether bacterium amide and pyraclostrobin weight ratio are 1：Synergy ratio is maximum when 1, and synergistic effect is the most apparent.
Application Example six：
For trying disease：Rice blast；Test medicine is provided by applicant.Experimental design：It is determined by pilot study
Fluorine ether bacterium amide and dimoxystrobin active compound or effective inhibition concentration range of the two different ratio mixture.
13 fluorine ether bacterium amide of table compounds the toxicity test analysis of results table to rice blast with dimoxystrobin
As shown in Table 13, fluorine ether bacterium amide is matched with dimoxystrobin 1：80~80：To the synergy ratio of rice blast when 1
SR is all higher than 1.5, illustrates the two 1：80~80：Mixture shows synergistic effect in 1 range, when fluorine ether bacterium amide and ether bacterium
The proportioning of amine is 1：30~30：When 1, synergistic effect is more prominent, and synergy ratio is 2.25 or more, especially when fluorine ether bacterium acyl
Amine is 1 with dimoxystrobin weight ratio：Synergy ratio is maximum when 1, and synergistic effect is the most apparent.
Application Example seven：
For trying disease：Wheat smut；Test medicine is provided by applicant；Experimental design：It is determined by pilot study
Fluorine ether bacterium amide and fluoxastrobin active compound or effective inhibition concentration range of the two different ratio mixture.
Toxicity test result
14 fluorine ether bacterium amide of table compounds the toxicity test analysis of results table to wheat smut with fluoxastrobin
As shown in Table 14, fluorine ether bacterium amide is matched with fluoxastrobin 1：80~80：To the synergic ratio of wheat smut when 1
Value SR is all higher than 1.5, illustrates the two 1：80~80：Mixture shows synergistic effect in 1 range, when fluorine ether bacterium amide and fluorine
The proportioning of Fluoxastrobin is 1：25~20：When 1, synergistic effect becomes apparent protrusion, synergy ratio 2.30 or more, especially when
Fluorine ether bacterium amide is 2 with fluoxastrobin weight ratio：Synergy ratio is maximum when 3, and synergistic effect is the most apparent.
Application Example eight：
For trying disease：Wheat leaf blight；Test medicine is provided by applicant；Experimental design：It is determined by pilot study
Fluorine ether bacterium amide and ZEN 90160 active compound or effective inhibition concentration range of the two different ratio mixture.
Toxicity test result
15 fluorine ether bacterium amide of table compounds the toxicity test analysis of results table to wheat leaf blight with ZEN 90160
As shown in Table 15, fluorine ether bacterium amide is matched with ZEN 90160 1：80~80：To the synergic ratio of wheat leaf blight when 1
Value SR is all higher than 1.5, illustrates the two 1：80~80：Mixture shows synergistic effect in 1 range, when fluorine ether bacterium amide and pyridine
The proportioning of oxygen bacterium ester is 1：25~20：When 1, synergistic effect becomes apparent protrusion, synergy ratio 2.25 or more, especially when
Fluorine ether bacterium amide is 1 with ZEN 90160 weight ratio：Synergy ratio is maximum when 2, and synergistic effect is the most apparent.
Application Example nine：
For trying disease：Cucumber downy mildew；Test medicine is provided by applicant；Experimental design：It is determined by pilot study
Fluorine ether bacterium amide and Enestroburin active compound or effective inhibition concentration range of the two different ratio mixture.
Toxicity test result
16 fluorine ether bacterium amide of table compounds the toxicity test analysis of results table to cucumber downy mildew with Enestroburin
As shown in Table 16, fluorine ether bacterium amide is matched with Enestroburin 1：80~80：To the synergic ratio of cucumber downy mildew when 1
Value SR is all higher than 1.5, illustrates the two 1：80~80：Mixture shows synergistic effect in 1 range, when fluorine ether bacterium amide and alkene
The proportioning of trifloxystrobin is 1：25~20：When 1, synergistic effect becomes apparent protrusion, synergy ratio 2.20 or more, especially when
Fluorine ether bacterium amide is 2 with Enestroburin weight ratio：Synergy ratio is maximum when 3, and synergistic effect is the most apparent.
Application Example ten：
For trying disease：Downy mildew of garpe；Test medicine is provided by applicant；Experimental design：It is determined by pilot study
Fluorine ether bacterium amide and pyraoxystrobin active compound or effective inhibition concentration range of the two different ratio mixture.
Toxicity test result
17 fluorine ether bacterium amide of table compounds the toxicity test analysis of results table to downy mildew of garpe with pyraoxystrobin
As shown in Table 17, fluorine ether bacterium amide is matched with pyraoxystrobin 1：80~80：To the synergy ratio of downy mildew of garpe when 1
SR is all higher than 1.5, illustrates the two 1：80~80：Mixture shows synergistic effect in 1 range, when fluorine ether bacterium amide and azoles bacterium
The proportioning of ester is 1：20~25：When 1, synergistic effect becomes apparent protrusion, and synergy ratio is 2.25 or more, especially when fluorine ether
Bacterium amide is 3 with pyraoxystrobin weight ratio：Synergy ratio is maximum when 2, and synergistic effect is the most apparent.
It is found through experiment that：Fluorine ether bacterium amide with after active constituent B compounding in various crop rust, epidemic disease, sclerotiniose,
Gray mold, downy mildew, peronospora tabacina, spot defoliation, powdery mildew, scab, rice blast, banded sclerotial blight, shot hole, anthracnose,
The prevention of brown spot, leaf spot, leaf blight, spike rot, glume blight, net blotch or moire disease has apparent synergistic effect, increases
Effect ratio SR is all higher than 1.5.
Effect experiment part：Test medicine is researched and developed by applicant, is provided, 20% fluorine ether bacterium amide suspending agents of comparison medicament
(autogamy), 30% kresoxim-methyl wettable powder (purchased in market), 250 grams per liter Fluoxastrobin suspending agents (purchased in market), 50% trifloxystrobin suspending agent
(autogamy), 250 grams per liter pyraclostrobin missible oils (purchased in market), 10% dimoxystrobin suspending agent (autogamy), 10% fluoxastrobin missible oil
(autogamy), 20% chlorfenapyr suspending agent (autogamy), 20% Enestroburin suspending agent (autogamy), 20% pyraoxystrobin suspending agent are (certainly
With).
Ten monofluoro-ether bacterium amide of Application Example and active constituent B and its compounding prevention wheat rust test of pesticide effectiveness
This test arrangement investigates wheat rust disease index before Shaanxi Province Weinan City Pucheng County, medicine, occurs just in disease
Phase dispenser 3 days after dispenser, investigates disease indexes and calculates preventive effect for 10 days, 20 days.Test result is as follows：
18 fluorine ether bacterium amide of table and active constituent B and its compounding prevention wheat rust test of pesticide effectiveness
As can be seen from Table 18, wheat rust can be effectively prevented after fluorine ether bacterium amide and active constituent B compoundings, through applicant
Experiment also can effectively prevent wheat glume blotch, moire disease after finding fluorine ether bacterium amide and active constituent B compoundings, and control effect is high
In 96%, it is better than the preventive effect of single dose, and preventive effect phase is long.It has no adverse effects to target crop in experiment scope of medication.
Ten difluoro ether bacterium amide of Application Example and active constituent B and its compounding prevention powdery mildew of cucumber test of pesticide effectiveness
This test arrangement investigates powdery mildew of cucumber disease index before Xian District, Shanxi Province suburban area, medicine, occurs just in disease
Phase dispenser 5 days after dispenser, investigates disease indexes and calculates preventive effect for 15 days, 30 days.Test result is as follows：
19 fluorine ether bacterium amide of table and active constituent B and its compounding prevention powdery mildew of cucumber test of pesticide effectiveness
As can be seen from Table 19, powdery mildew of cucumber can be effectively prevented after fluorine ether bacterium amide and active constituent B compoundings, through application
People test find fluorine ether bacterium amide with after active constituent B compounding also can effectively cucumber blight disease, sclerotiniose, anthracnose, prevention
Effect is above 95%, is better than the preventive effect of single dose, and preventive effect phase is long.To target crop without bad shadow in experiment scope of medication
It rings.Ten trifluoro bacterium amide of Application Example and active constituent B and its compounding prevention rice blast test of pesticide effectiveness
This test arrangement investigates rice blast disease index before Shaanxi Province Hanzhong suburban area, medicine, occurs just in disease
Phase dispenser 10 days after dispenser, investigates disease indexes and calculates preventive effect for 20 days, 30 days.Test result is as follows：
20 fluorine ether bacterium amide of table and active constituent B and its compounding prevention rice blast test of pesticide effectiveness
As can be seen from Table 20, fluorine ether bacterium amide and active constituent B and its compounding prevention rice blast, are tried through applicant
Rice sheath blight disease, leaf spot, leaf blight, prevention effect also can be effectively prevented after issuing after examination and approval existing fluorine ether bacterium amide and active constituent B compoundings
Fruit is above 96%, is better than the preventive effect of single dose, and preventive effect phase is long.It has no adverse effects to target crop in experiment scope of medication.
Ten tetrafluoro ether bacterium amide of Application Example and active constituent B and its compounding prevention downy mildew of garpe test of pesticide effectiveness
This test arrangement investigates downy mildew of garpe disease index before Shaanxi Province Weinan City Dali County, medicine, occurs in disease
Initial stage dispenser 1 day after dispenser, investigates disease indexes and calculates preventive effect for 5 days, 15 days.Test result is as follows：
21 fluorine ether bacterium amide of table and active constituent B and its compounding prevention downy mildew of garpe test of pesticide effectiveness
As can be seen from Table 21, downy mildew of garpe can be effectively prevented after fluorine ether bacterium amide and active constituent B compoundings, through application
People, which tests, to be found also can effectively prevent grape grey mould after fluorine ether bacterium amide is compounded with active constituent B, and control effect is above
95%, it is better than the preventive effect of single dose, and preventive effect phase is long.It has no adverse effects to target crop in experiment scope of medication.
15 fluorine ether bacterium amide of Application Example and active constituent B and its compounding prevention pear scab test of pesticide effectiveness
This test arrangement investigates pear scab disease index before Xianyang, Shanxi province suburban area, medicine, occurs just in disease
Phase dispenser 3 days after dispenser, investigates disease indexes and calculates preventive effect for 10 days, 20 days.Test result is as follows：
22 fluorine ether bacterium amide of table and active constituent B and its compounding prevention pear scab test of pesticide effectiveness
As can be seen from Table 22, pear scab can be effectively prevented after fluorine ether bacterium amide and active constituent B compoundings, through application
People, which tests, to be found also can effectively prevent pear tree brown spot after fluorine ether bacterium amide is compounded with active constituent B, and control effect is above
95%, it is better than the preventive effect of single dose, and preventive effect phase is long.It has no adverse effects to target crop in experiment scope of medication.
Ten hexafluoro ether bacterium amide of Application Example and active constituent B and its compounding prevention alternaria leaf spot of apple test of pesticide effectiveness
This test arrangement investigates alternaria leaf spot of apple disease index before Shaanxi Province's Weinan City Baishui County, medicine, in disease
Early period of origination dispenser 5 days after dispenser, investigates disease indexes and calculates preventive effect for 15 days, 30 days.Test result is as follows：
23 oxygen ether bacterium amide of table and active constituent B and its compounding prevention alternaria leaf spot of apple test of pesticide effectiveness
As can be seen from Table 23, alternaria leaf spot of apple can be effectively prevented after fluorine ether bacterium amide and active constituent B compoundings, passed through
Applicant, which tests, to be found also can effectively prevent apple marssonina leaf spot, spike rot, scab after fluorine ether bacterium amide is compounded with active constituent B
Disease, powdery mildew, control effect are above 96%, and control effect is superior to the preventive effect of single dose, and preventive effect phase is long.In experiment medication model
It encloses and interior has no adverse effects to target crop.
The experiment by different places throughout the country obtains afterwards, fluorine ether bacterium amide with after active constituent B compounding to a variety of
Rust, epidemic disease on crop, sclerotiniose, gray mold, downy mildew, peronospora tabacina, spot defoliation, powdery mildew, scab, rice blast
Disease, banded sclerotial blight, shot hole, anthracnose, brown spot, leaf spot, leaf blight, spike rot, glume blight, net blotch or moire disease etc. are normal
See that the preventive effect of disease 95% or more, is better than single dose preventive effect, synergistic effect is apparent.
Claims (6)
1. a kind of bactericidal composition of fluorine-containing ether bacterium amide and methoxy acrylic, contains active components A and active constituent
B, it is characterised in that：Active components A is 1: 80~80: 1 with active constituent B weight ratios, and the active components A is selected from fluorine ether bacterium
Amide, active constituent B are Fluoxastrobin.
2. the bactericidal composition of fluorine-containing ether bacterium amide and methoxy acrylic according to claim 1, feature exist
In：Active components A and the weight ratio of active constituent B are 1: 60~60: 1.
3. the bactericidal composition of fluorine-containing ether bacterium amide and methoxy acrylic according to claim 2, feature exist
In：
The weight ratio of fluorine ether bacterium amide and Fluoxastrobin is 1: 30~25: 1.
4. the Bactericidal composite of fluorine-containing ether bacterium amide and methoxy acrylic according to any one of claim 1 to 3
Object, it is characterised in that：Wettable powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, micro- is made in composition
Capsule suspending agent or microcapsule suspension-suspendinagent agent.
5. the bactericidal composition of fluorine-containing ether bacterium amide according to claim 4 and methoxy acrylic is for preventing agriculture
The purposes of disease on crop.
6. purposes according to claim 5, it is characterised in that：The disease be rust, epidemic disease, sclerotiniose, gray mold,
Downy mildew, peronospora tabacina, spot defoliation, powdery mildew, scab, rice blast, banded sclerotial blight, shot hole, anthracnose, brown spot,
Leaf spot, leaf blight, spike rot, glume blight, net blotch or moire disease.
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| CN201310403719.5A CN104412981B (en) | 2013-09-02 | 2013-09-02 | A kind of bactericidal composition of fluorine-containing ether bacterium amide and methoxy acrylic |
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| CN104886095B (en) * | 2015-06-04 | 2016-10-05 | 山东棉花研究中心 | A kind of microbicide compositions of fluorine-containing ether bacterium amide |
| CN105794781A (en) * | 2016-03-31 | 2016-07-27 | 太仓市东泾农场专业合作社 | Antibacterial compound containing benzamide fungicide and coumoxystrobin |
| CN105831132A (en) * | 2016-04-28 | 2016-08-10 | 安徽农业大学 | Sterilization composition containing benzothiostrobin and fluoride ether bacteria amide |
| CN105961396B (en) * | 2016-05-26 | 2018-01-26 | 南京华洲药业有限公司 | A kind of bactericidal composition and its application of fluorine-containing ether bacterium acid amides and SYP-3375 |
| CN106942252A (en) * | 2017-04-01 | 2017-07-14 | 山东省联合农药工业有限公司 | A kind of composite bactericide of fluorine-containing ether bacterium acid amides |
| CN107156133A (en) * | 2017-06-21 | 2017-09-15 | 天峨县平昌生态农业有限公司 | A kind of bactericidal composition and its application |
| CN107279163A (en) * | 2017-07-27 | 2017-10-24 | 北京明德立达农业科技有限公司 | A kind of microcapsule suspension suspending agent of fluorine-containing ether bacterium acid amides and pyraclostrobin and preparation method thereof |
Citations (2)
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| WO2010139653A1 (en) * | 2009-06-04 | 2010-12-09 | Basf Se | Fungicidal mixtures comprising heteraromatic sulfonamides |
| CN102365956A (en) * | 2011-11-03 | 2012-03-07 | 陕西美邦农药有限公司 | Sterilization composition containing fluopicolide and methoxyl acrylic acid ester compounds |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010139653A1 (en) * | 2009-06-04 | 2010-12-09 | Basf Se | Fungicidal mixtures comprising heteraromatic sulfonamides |
| CN102365956A (en) * | 2011-11-03 | 2012-03-07 | 陕西美邦农药有限公司 | Sterilization composition containing fluopicolide and methoxyl acrylic acid ester compounds |
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| 氟醚菌酰胺液相色谱法含量的测定;张晓霞 等;《山东化工》;20120915(第9期);第67-68、71页 * |
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