CN104106582B - A kind of bactericidal composition containing chlorine nalidixic bacterium ester and thiocarbamates - Google Patents
A kind of bactericidal composition containing chlorine nalidixic bacterium ester and thiocarbamates Download PDFInfo
- Publication number
- CN104106582B CN104106582B CN201310139019.XA CN201310139019A CN104106582B CN 104106582 B CN104106582 B CN 104106582B CN 201310139019 A CN201310139019 A CN 201310139019A CN 104106582 B CN104106582 B CN 104106582B
- Authority
- CN
- China
- Prior art keywords
- bacterium ester
- nalidixic bacterium
- chlorine nalidixic
- active component
- thiocarbamates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 241000894006 Bacteria Species 0.000 title claims abstract description 71
- MHWLWQUZZRMNGJ-UHFFFAOYSA-N nalidixic acid Chemical compound C1=C(C)N=C2N(CC)C=C(C(O)=O)C(=O)C2=C1 MHWLWQUZZRMNGJ-UHFFFAOYSA-N 0.000 title claims abstract description 70
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 title claims abstract description 68
- 239000000460 chlorine Substances 0.000 title claims abstract description 68
- 229910052801 chlorine Inorganic materials 0.000 title claims abstract description 68
- 150000002148 esters Chemical class 0.000 title claims abstract description 67
- 239000000203 mixture Substances 0.000 title claims abstract description 45
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 18
- 150000003558 thiocarbamic acid derivatives Chemical class 0.000 title claims abstract description 12
- 201000010099 disease Diseases 0.000 claims abstract description 29
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 29
- AMHNZOICSMBGDH-UHFFFAOYSA-L zineb Chemical compound [Zn+2].[S-]C(=S)NCCNC([S-])=S AMHNZOICSMBGDH-UHFFFAOYSA-L 0.000 claims abstract description 19
- 239000000375 suspending agent Substances 0.000 claims description 16
- 235000007164 Oryza sativa Nutrition 0.000 claims description 14
- 235000009566 rice Nutrition 0.000 claims description 14
- 241000233679 Peronosporaceae Species 0.000 claims description 12
- 239000003094 microcapsule Substances 0.000 claims description 12
- 239000000839 emulsion Substances 0.000 claims description 11
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 241000221785 Erysiphales Species 0.000 claims description 7
- 239000004562 water dispersible granule Substances 0.000 claims description 7
- 239000004563 wettable powder Substances 0.000 claims description 7
- 206010039509 Scab Diseases 0.000 claims description 6
- 239000004530 micro-emulsion Substances 0.000 claims description 6
- 239000000725 suspension Substances 0.000 claims description 6
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 5
- 230000035613 defoliation Effects 0.000 claims description 4
- 240000007594 Oryza sativa Species 0.000 claims 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 abstract description 32
- 230000002195 synergetic effect Effects 0.000 abstract description 20
- 239000011717 all-trans-retinol Substances 0.000 abstract description 16
- 235000019169 all-trans-retinol Nutrition 0.000 abstract description 16
- 239000005823 Propineb Substances 0.000 abstract description 14
- KKMLIVYBGSAJPM-UHFFFAOYSA-L propineb Chemical compound [Zn+2].[S-]C(=S)NC(C)CNC([S-])=S KKMLIVYBGSAJPM-UHFFFAOYSA-L 0.000 abstract description 14
- 230000000694 effects Effects 0.000 abstract description 13
- 150000001875 compounds Chemical class 0.000 abstract description 11
- 230000000855 fungicidal effect Effects 0.000 abstract description 3
- 238000001228 spectrum Methods 0.000 abstract description 2
- 238000005406 washing Methods 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 description 28
- 238000012360 testing method Methods 0.000 description 22
- 238000013329 compounding Methods 0.000 description 21
- 239000003814 drug Substances 0.000 description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 241000209094 Oryza Species 0.000 description 13
- 239000013530 defoamer Substances 0.000 description 13
- 239000002270 dispersing agent Substances 0.000 description 13
- 239000000575 pesticide Substances 0.000 description 11
- 239000012071 phase Substances 0.000 description 11
- 239000003995 emulsifying agent Substances 0.000 description 10
- 239000002904 solvent Substances 0.000 description 10
- 238000002474 experimental method Methods 0.000 description 9
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 8
- 240000003768 Solanum lycopersicum Species 0.000 description 8
- 230000002528 anti-freeze Effects 0.000 description 8
- 239000008367 deionised water Substances 0.000 description 8
- 229910021641 deionized water Inorganic materials 0.000 description 8
- 239000002562 thickening agent Substances 0.000 description 8
- 239000000080 wetting agent Substances 0.000 description 8
- 240000008067 Cucumis sativus Species 0.000 description 7
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 238000009472 formulation Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 231100000820 toxicity test Toxicity 0.000 description 6
- 241001530056 Athelia rolfsii Species 0.000 description 5
- 206010067482 No adverse event Diseases 0.000 description 5
- 239000008346 aqueous phase Substances 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 235000013399 edible fruits Nutrition 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 241000223600 Alternaria Species 0.000 description 4
- 241000193738 Bacillus anthracis Species 0.000 description 4
- 241000219109 Citrullus Species 0.000 description 4
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 description 4
- 206010011732 Cyst Diseases 0.000 description 4
- 208000031513 cyst Diseases 0.000 description 4
- 239000000945 filler Substances 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 229920002521 macromolecule Polymers 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 230000008485 antagonism Effects 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 239000007884 disintegrant Substances 0.000 description 3
- -1 ester compounds Chemical class 0.000 description 3
- 238000013401 experimental design Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000003002 pH adjusting agent Substances 0.000 description 3
- 230000001018 virulence Effects 0.000 description 3
- 239000011701 zinc Substances 0.000 description 3
- 229910052725 zinc Inorganic materials 0.000 description 3
- 241000219112 Cucumis Species 0.000 description 2
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 240000008042 Zea mays Species 0.000 description 2
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 2
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000011149 active material Substances 0.000 description 2
- 239000003905 agrochemical Substances 0.000 description 2
- 239000012752 auxiliary agent Substances 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 238000000498 ball milling Methods 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- 235000009973 maize Nutrition 0.000 description 2
- GTCAXTIRRLKXRU-UHFFFAOYSA-N methyl carbamate Chemical compound COC(N)=O GTCAXTIRRLKXRU-UHFFFAOYSA-N 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000010008 shearing Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 1
- 102100025287 Cytochrome b Human genes 0.000 description 1
- 102100030497 Cytochrome c Human genes 0.000 description 1
- 108010075028 Cytochromes b Proteins 0.000 description 1
- 108010075031 Cytochromes c Proteins 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 238000012271 agricultural production Methods 0.000 description 1
- 239000007798 antifreeze agent Substances 0.000 description 1
- 230000010165 autogamy Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- XCJXQCUJXDUNDN-UHFFFAOYSA-N chlordene Chemical compound C12C=CCC2C2(Cl)C(Cl)=C(Cl)C1(Cl)C2(Cl)Cl XCJXQCUJXDUNDN-UHFFFAOYSA-N 0.000 description 1
- ASDRZZPTJLDISZ-UHFFFAOYSA-N chlorine;pyridine Chemical compound [Cl].C1=CC=NC=C1 ASDRZZPTJLDISZ-UHFFFAOYSA-N 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000002242 deionisation method Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000004495 emulsifiable concentrate Substances 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- FRCCEHPWNOQAEU-UHFFFAOYSA-N heptachlor Chemical compound ClC1=C(Cl)C2(Cl)C3C=CC(Cl)C3C1(Cl)C2(Cl)Cl FRCCEHPWNOQAEU-UHFFFAOYSA-N 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 239000010871 livestock manure Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000005453 pelletization Methods 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 150000003233 pyrroles Chemical class 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of bactericidal composition containing chlorine nalidixic bacterium ester and thiocarbamates, effective active composition is active components A and active component B, and active components A is selected from chlorine nalidixic bacterium ester, and active component B is selected from any one following compound：Propineb, Carbatene, zineb, and active components A and active component B weight ratio are 1: 80~60: 1.The present composition has greater activity to the multiple diseases in various crop, and has obvious synergistic effect, expands fungicidal spectrum.And with the characteristics of dosage is small, resistance of rainwater washing against, and synergy is obvious.
Description
Technical field
The invention belongs to technical field of pesticide, is related to a kind of Bactericidal composite containing chlorine nalidixic bacterium ester and thiocarbamates
Application of the thing in crop disease.
Technical background
Chlorine nalidixic bacterium ester：Molecular formula is C15H13Cl3N2O4, chemical name is N- methoxyl groups-N- [2- [[(3,5,6- trichlorine pyrroles
Pyridine -2- bases) oxygen] methyl] phenyl] methyl carbamate, belong to carbamate fungicide, outward appearance is pale solid, with
The mechanism of action of other methoxy acrylic bactericides is the same, and chlorine nalidixic bacterium ester is also mitochondrial respiratory inhibitor, that is,
Cause to imitate by suppressing the breathing of electronics transfer Mitochondria between cytochrome b and c.
In the real process of agricultural production, controlling disease is easiest to generate the problem that the generation of disease drug resistance.No
Compounded with kind composition, be to prevent and treat the very common method of resistance disease.Heterogeneity is compounded, and is imitated according to practical application
Fruit, to judge that certain compounding is synergy plus and or antagonism.In most cases, the compounding effect of agricultural chemicals is all to add
And effect, really have that the compounding of synergistic effect is seldom, especially synergistic effect clearly, the very high compounding of synergy ratio just more
It is few.Studied by inventor, find mutually to compound chlorine nalidixic bacterium ester and Propineb, Carbatene or zineb, in certain limit
Inside there is a good synergistic effect, and about chlorine nalidixic bacterium ester compounding related to Propineb, Carbatene or zineb, at present at home and abroad
There is not yet relevant report.
The content of the invention
The purpose of the present invention is to propose to it is a kind of with synergistic function, use cost is low, preventive effect is good contains chlorine nalidixic bacterium ester
With the bactericidal composition of thiocarbamates.
The present invention is to be achieved through the following technical solutions：
A kind of bactericidal composition containing chlorine nalidixic bacterium ester and thiocarbamates, contains active components A and active component
B, active components A are 1: 80~60: 1 with active component B weight ratio, and described active components A is selected from chlorine nalidixic bacterium ester, active component
The one kind of B in Propineb, Carbatene or zineb；Preferably active components A and active component B weight ratio for 1 ︰ 60~
40 ︰ 1；More preferably the weight ratio of chlorine nalidixic bacterium ester and Propineb is 1: 24~10: 1, and the weight ratio of chlorine nalidixic bacterium ester and Carbatene is 1
: 30~10: 1, the weight ratio of chlorine nalidixic bacterium ester and zineb is 1: 34~10: 1；The most preferably weight of chlorine nalidixic bacterium ester and Propineb
Than for 1: 19~1: 1, the weight ratio of chlorine nalidixic bacterium ester and Carbatene is 1: 19~1: 1, the weight ratio of chlorine nalidixic bacterium ester and zineb is 1
: 29~9: 1.
The bactericidal composition of the present invention, can be processed into acceptable formulation in any sterilization on demand, wherein more preferably
Formulation for wettable powder, water dispersible granules, suspending agent, aqueous emulsion, microemulsion, microcapsule suspending agent.
The described bactericidal composition containing chlorine nalidixic bacterium ester and thiocarbamates is used for the disease for preventing and treating crop；It is described
Crop be cereal crops, it is legume crop, fibre crops, sugar crop, melon crop, fruits crop, dry fruit crop, thermophilic
Good crop, root crop, oil crops, flower crop, medicinal crop, crop, green manure pasture crop；Described disease
For downy mildew, rice blast, false smut, banded sclerotial blight, powdery mildew, sclerotiniose, anthracnose, epidemic disease, spot defoliation, brown spot, white
Maize ear rot, scab, ring spot, rust.
The amount of application when content of active component depends on being used alone in the bactericidal composition of the present invention, also depends on one
The mixed ratio and synergistic effect degree of kind compound and another compound, at the same it is also relevant with target disease.Usual group
The weight percentage of active component is the 1%~90% of gross weight, preferably 5%~80% in compound.According to different preparations
Type, active component content scope are different.Liquids in general preparation contains by weight 1%~60% active material, preferably
Ground is 5%~50%；Solid pharmaceutical preparation contains by weight 5%~80% active material, preferably 10%~80%.
The present invention bactericidal composition at least contain a kind of surfactant, in favor of administration when active component in water
It is scattered.Surface-active contents are the 2%~30% of total formulation weight, and surplus is solid or liquid diluent.
The bactericidal composition of the present invention can be used by user before use through dilution or directly.Its preparation can be by ability
Prepared by the processing method well known to field technique personnel, i.e., after active component is mixed with liquid flux or solid carrier, add
One or more in surfactant such as dispersant, stabilizer, wetting agent, binding agent, disintegrant, defoamer.According to not
Same formulation, antifreeze known in those skilled in the art etc. can also be contained in preparation.
Composition includes following component and content when wettable powder is made：Active components A 0.5%~60%, active component
B0.5%~80%, dispersant 1%~12%, wetting agent 1%~8%, filler surplus.
Composition includes following component and content when water dispersible granules are made：Active components A 0.5%~60%, active component
B0.5%~80%, dispersant 1%~12%, wetting agent 1%~8%, disintegrant 1%~10%, binding agent 0~8%, filler surplus.
Composition includes following component and content when suspending agent is made：Active components A 0.5%~50%, active component B0.5%
~50%, dispersant 1%~10%, wetting agent 1%~10%, defoamer 0.01%~2%, thickener 0~2%, antifreeze 0~8%, go
Ionized water adds to 100%.
Composition includes following component and content when aqueous emulsion is made：Active components A 0.5%~50%, active component B0.5%
~50%, solvent 1%~20%, emulsifying agent 1%~12%, antifreeze 0~8%, defoamer 0.01%~2%, thickener 0~2%, go from
Sub- water adds to 100%.
Composition includes following component and content when microemulsion is made：Active components A 0.5%~50%, active component B0.5%
~50%, emulsifying agent 3%~25%, solvent 1%~10%, antifreeze 0~8%, defoamer 0.01%~2%, deionized water add to 100%.
Composition includes following component and content when suspension emulsion is made：Active components A 0.5%~50%, active component B0.5%
~50%, emulsifying agent 1%~10%, dispersant 1%~10%, solvent 1%~20%, defoamer 0.01%~2%, thickener 0~2%, anti-
Freeze agent 0~8%, deionized water adds to 100%.
Composition includes following component and content when microcapsule suspending agent is made：Active components A 0.5%~50%, active component
B0.5%~50%, macromolecule cyst material 1%~10%, dispersant 2%~10%, solvent 1%~10%, emulsifying agent 1%~7%, pH are adjusted
Section agent 0.01%~5%, defoamer 0.01%~2%, deionized water add to 100%.
Composition includes following component and content when microcapsule suspension-suspendinagent agent is made：Active components A 0.5%~50%, activity
Composition B0.5%~50%, macromolecule cyst material 1%~12%, dispersant 1%~12%, wetting agent 1%~8%, solvent 1%~15%,
Emulsifying agent 1%~8%, defoamer 0.01%~2%, thickener 0~2%, pH adjusting agent 0.01%~5%, deionized water add to 100%.
The wettable powder the key technical indexes of the present invention：
The water dispersible granules the key technical indexes of the present invention：
The suspending agent the key technical indexes of the present invention：
The aqueous emulsion the key technical indexes of the present invention：
The microemulsion the key technical indexes of the present invention：
The suspension emulsion the key technical indexes of the present invention：
The microcapsule suspending agent the key technical indexes of the present invention：
The microcapsule suspension-suspendinagent agent the key technical indexes of the present invention：
The advantage of the invention is that：
（1）The present composition has good synergy and lasting effect within the specific limits, and preventive effect is higher than single dose；（2）Agriculture
Medicinal dose is reduced, and is reduced residual quantity of the agricultural chemicals on crop, is mitigated environmental pollution；（3）Fungicidal spectrum is expanded, to multiple diseases
Such as downy mildew, rice blast, false smut, banded sclerotial blight, powdery mildew, sclerotiniose, anthracnose, epidemic disease, spot defoliation, brown spot, white
Maize ear rot, scab, ring spot, rust etc. have greater activity.
Embodiment
With reference to embodiment to further instruction of the present invention, the percentage in embodiment is weight percentage, but
The invention is not limited in this.
Application Example one
The wettable powder of embodiment 1~11
Chlorine nalidixic bacterium ester, active component B, dispersant, wetting agent, filler are mixed, are well mixed in mixed cylinder, through air-flow
Pulverizer remixes uniformly after crushing, you can wettable powder product of the present invention is made.Specifically it is shown in Table 1.
The each component of 1 embodiment of table 1~11 and content
The water dispersible granules of embodiment 12~22
Chlorine nalidixic bacterium ester, active component B, dispersant, wetting agent, disintegrant, filler etc. are needed through air-flow crushing together
The particle diameter wanted, adds binding agent（Can add to be not added with）Etc. other auxiliary agents, materials of pelletizing are obtained.Item is quantified into feeding fluid bed
In granulating drier after granulation and drying, you can water dispersible granules product of the present invention is made, is specifically shown in Table 2.
The each component of 2 embodiment of table 12~22 and content
Propineb, Carbatene, zineb in table 1,2 are exchanged, novel formulation can be made.
The suspending agent of embodiment 23~29
By dispersant, wetting agent, defoamer, thickener（Can add to be not added with）, antifreeze（Can add to be not added with）, by a high speed
Shear-mixed is uniform, adds chlorine nalidixic bacterium ester, active component B, ball milling 2~3 hours in ball mill, makes diameter of particle all in 5 μ
Below m, surplus are supplied with deionized water, you can suspending agent product of the present invention is made, is specifically shown in Table 3.
The each component of 3 embodiment of table 23~29 and content
The aqueous emulsion of embodiment 30~34
Chlorine nalidixic bacterium ester, active component B, solvent, emulsifying agent are added together, make to be dissolved into homogeneous oil phase；By deionized water,
Antifreeze（Can add to be not added with）, thickener（Can add to be not added with）, defoamer mix, into homogeneous aqueous phase.In high-speed stirred
Under, aqueous phase is added into oil phase, aqueous emulsion product of the present invention is made.Specifically it is shown in Table 4.
The each component of 4 embodiment of table 30~34 and content
The microemulsion of embodiment 35~39
Chlorine nalidixic bacterium ester, active component B are dissolved in the homogenizer equipped with solvent, by emulsifying agent, antifreeze（Can add can not
Add）, defoamer, be added in the homogenizer equipped with above-mentioned solution, surplus gives mixing strongly and even after being supplied with deionized water
Change, finally obtain the transparent microemulsion product of the present invention of clear appearance.Specifically it is shown in Table 5.
The each component of 5 embodiment of table 35~39 and content
Carbatene, zineb in table 3~5 are exchanged, novel formulation can be made.
The suspension emulsion of embodiment 40~44
By dispersant, defoamer, thickener（Can add to be not added with）, antifreeze（Can add to be not added with）Mixed by high speed shear
Uniformly, add active component B, ball milling 2~3 hours in ball mill, make diameter of particle all less than 5 μm, it is obtained active into
Divide B suspending agents, then directly emulsify chlorine nalidixic bacterium ester, emulsifying agent, solvent and various auxiliary agents in suspending agent with high speed agitator,
Suspension emulsion product of the present invention is made.Specifically it is shown in Table 6.
The each component of 6 embodiment of table 40~44 and content
The microcapsule suspending agent of embodiment 45~47
Chlorine nalidixic bacterium ester, active component B, macromolecule cyst material, solvent are mixed, makes to be dissolved into homogeneous oil phase, is shearing
Under the conditions of, by oil phase be added to containing emulsifying agent, pH adjusting agent, dispersant, defoamer aqueous phase solution in, surplus deionization
Water is supplied, and two kinds of materials react in oil-water interfaces, forms high score ascus wall, and well dispersed micro- of the present composition is made
Capsule suspending agent product.Specifically it is shown in Table 7.
The each component of 7 embodiment of table 45~47 and content
The microcapsule suspension-suspendinagent agent of embodiment 48~50
Active component B, macromolecule cyst material, solvent are mixed, make to be dissolved into homogeneous oil phase, by oil phase in shearing condition
Under be added to containing emulsifying agent, pH adjusting agent aqueous phase solution in, well dispersed microcapsule suspending agent is made.By dispersant, wet
Moisten agent, defoamer, thickener（Can add to be not added with）It is well mixed by high speed shear, adds chlorine nalidixic bacterium ester, the ball in ball mill
Mill 2~3 hours, makes diameter of particle all below 5 μm, and suspending agent is made, suspending agent then is added into micro-capsule suspension
Aqueous phase solution in, deionized water supplies surplus, and the well dispersed microcapsule suspension-suspendinagent agent product of the present composition is made.
Specifically it is shown in Table 8.
The each component of 8 embodiment of table 48~50 and content
Active component B is Carbatene or zineb in table 6~8.
The embodiment of the present invention is the method being combined using Toxicity Determination and field test.First pass through indoor virulence survey
Calmly, the synergy ratio after clear and definite two kinds of medicaments compound by a certain percentage（SR）, SR ＜ 0.5 are antagonism, 0.5≤SR≤1.5
For summation action, SR ＞ 1.5 are synergistic effect, on this basis, then carry out field test.
Test method：After prerun determines the effective inhibition concentration scope of each medicament, medicament sets 5 respectively by active constituent content
Individual dosage processing, if clear water compares.Reference《Farm-chemical indoor determination test rule bactericide》Carry out, using mycelial growth speed
Rate method determines virulence of the medicament to crop germ.Colony diameter is measured with crossing method after 72h, calculates the net growth of each processing
Amount, mycelial growth inhibition rate.
Net growth（mm）=measurement colony diameter -5
Mycelial growth inhibition rate is converted into probit value（y）, liquor strength（μg/mL）It is converted into logarithm value（x）, with minimum
Square law tries to achieve virulence regression equation（y=a+bx）, and thus calculate the EC of every kind of medicament50Value.Simultaneously according to Wadley method meters
Calculate two medicament different ratio synergy ratios（SR）, SR ＜ 0.5 are antagonism, and 0.5≤SR≤1.5 are summation action, SR
＞ 1.5 is synergistic effect.Calculation formula is as follows：
Wherein：A, b is respectively active components A and active component B ratio shared in combination；
A is chlorine nalidixic bacterium ester；
B is selected from one of Propineb, Carbatene or zineb kind.
Application Example two：
For trying disease：Cucumber downy mildew, test medicine provide by Shaanxi Meibang Pesticide Co., Ltd., experimental design：Through
Cross effective inhibition concentration scope that pilot study determines chlorine nalidixic bacterium ester and both Propinebs different ratio mixture.
Toxicity test result
The chlorine nalidixic bacterium ester of table 9 compounds the toxicity test analysis of results table to cucumber downy mildew with Propineb
As shown in Table 9, chlorine nalidixic bacterium ester compounds the proportioning for preventing and treating cucumber downy mildew in 1 80~60 ︰ 1 of ︰ with Propineb, synergy
Ratio SR is all higher than 1.5, illustrates that both show synergistic effect at the mixture in the range of the ︰ 1 of 1 ︰ 80~60, chlorine nalidixic bacterium ester is gloomy with third
The proportioning of zinc is 1: 24~10: 1, and synergistic effect is more prominent, and synergy ratio is more than 2.30.Tested through applicant and find chlorine
The proportioning of nalidixic bacterium ester and Propineb is 10 ︰ 1,5 ︰ 1,1 ︰ 1,1 ︰ 5,1 ︰ 6,1 ︰ 7,1 ︰ 8,1 ︰ 9,1 ︰ 10,1 ︰ 11,1 ︰ 12,1 ︰ 13,1 ︰
14th, 1 ︰ 15,1 ︰ 16,1 ︰ 17,1 ︰ 18,1 ︰ 19,1 ︰ 20,1 ︰ 21,1 ︰ 22,1 ︰ 23,1 ︰ 24, wherein chlorine nalidixic bacterium ester and Propineb weight
Than for 1：Synergy ratio is maximum when 14, and synergistic effect is the most obvious.
Application Example three：
For trying disease：Rice blast, test medicine provide by Shaanxi Meibang Pesticide Co., Ltd., experimental design：Through
Cross pilot study and determine chlorine nalidixic bacterium ester and Carbatene active compound and effective inhibition concentration scope of the two different ratio mixture.
Toxicity test result
The chlorine nalidixic bacterium ester of table 10 compounds the toxicity test analysis of results table to rice blast with Carbatene
As shown in Table 10, chlorine nalidixic bacterium ester increases with the proportioning of Carbatene compounding preventing and treating rice blast in 1 80~60 ︰ 1 of ︰
Effect ratio SR is all higher than 1.5, illustrates that both show synergistic effect, chlorine nalidixic bacterium ester and generation at the mixture in the range of the ︰ 1 of 1 ︰ 80~60
Gloomy proportioning is 1: 30~10: 1, and synergistic effect is more prominent, and synergy ratio is more than 2.30.Test and find through applicant
The proportioning of chlorine nalidixic bacterium ester and Carbatene is 10 ︰ 1,5 ︰ 1,1 ︰ 1,1 ︰ 2,1 ︰ 3,1 ︰ 4,1 ︰ 5,1 ︰ 6,1 ︰ 7,1 ︰ 8,1 ︰ 9,1 ︰ 10,1 ︰
11st, 1 ︰ 16,1 ︰ 17,1 ︰ 18,1 ︰ 19,1 ︰ 20,1 ︰ 25,1 ︰ 30, wherein chlorine nalidixic bacterium ester are 1 with Carbatene weight ratio：Synergic ratio when 9
Value is maximum, and synergistic effect is the most obvious.
Application Example four：
For trying disease：Tomato blight, test medicine provide by Shaanxi Meibang Pesticide Co., Ltd., experimental design：By
Pilot study determines chlorine nalidixic bacterium ester and zineb active compound and effective inhibition concentration scope of the two different ratio mixture.
Toxicity test result
The chlorine nalidixic bacterium ester of table 11 compounds the toxicity test analysis of results table to tomato blight with zineb
As shown in Table 11, chlorine nalidixic bacterium ester compounds the proportioning for preventing and treating tomato blight in 1 80~60 ︰ 1 of ︰ with zineb, synergy
Ratio SR is all higher than 1.5, illustrates that both show synergistic effect, chlorine nalidixic bacterium ester and Dai Sen at the mixture in the range of the ︰ 1 of 1 ︰ 80~60
The proportioning of zinc is 1: 34~1: 1, and synergistic effect is more prominent, and synergy ratio is more than 2.30.Tested through applicant and find chlorine
The proportioning of nalidixic bacterium ester and zineb be 1 ︰ 1,1 ︰ 5,1 ︰ 6,1 ︰ 7,1 ︰ 8,1 ︰ 9,1 ︰ 10,1 ︰ 11,1 ︰ 16,1 ︰ 17,1 ︰ 18,1 ︰ 19,
1 ︰ 20,1 ︰ 21,1 ︰ 22,1 ︰ 23,1 ︰ 24,1 ︰ 25,1 ︰ 26,1 ︰ 27,1 ︰ 28,1 ︰ 29,1 ︰ 30, wherein 1 ︰ 34, chlorine nalidixic bacterium ester and generation
Gloomy zinc weight ratio is 1：Synergy ratio is maximum when 19, and synergistic effect is the most obvious.
Found through experiment：Chlorine nalidixic bacterium ester is bent to the downy mildew in various crop, rice blast, rice after being compounded with active component B
Disease, banded sclerotial blight, powdery mildew, sclerotiniose, anthracnose, epidemic disease, spot defoliation, brown spot, white rot, scab, ring spot, rust
The preventing and treating of disease has obvious synergistic effect, and synergy ratio is more than 1.5.
Effect experiment part：Test medicine is researched and developed by Shaanxi Meibang Pesticide Co., Ltd., provided, the chlorine pyridine of comparison medicament 15%
Bacterium emulsifiable concentrate（Autogamy）, 70% Wettable propineb powder（It is purchased in market）, 70% Carbatene water dispersible granules（It is purchased in market）, 65% zineb
Wettable powder（It is purchased in market）.
The chlorine nalidixic bacterium ester of Application Example five and active component B and its compounding preventing and treating cucumber downy mildew test of pesticide effectiveness
This experimental arrangement investigates the cucumber downy mildew state of an illness before Shaanxi Province Jingyang County, medicine, in state of an illness first time at initial stage dispenser,
Every dispenser in 7 days once, is total to dispenser 2 times.7 days after second of dispenser, disease index is investigated respectively and calculates preventive effect within 14 days, 30 days.
Experimental result is as follows：
The chlorine nalidixic bacterium ester of table 12 and active component B and its compounding preventing and treating cucumber downy mildew test of pesticide effectiveness
As can be seen from Table 12, chlorine nalidixic bacterium ester is prevented and treated with can effectively prevent and treat cucumber downy mildew after active component B and its compounding
Effect is superior to the preventive effect of single dose, and preventive effect phase is grown.Target crop is had no adverse effects in experiment scope of medication.Simultaneously to Huang
Melon scab, powdery mildew, sclerotiniose also have good preventive effect, and preventive effect is up to more than 96%.
Application Example chlordene nalidixic bacterium ester and active component B and its compounding preventing and treating tomato blight test of pesticide effectiveness
This test arrangement investigates the tomato blight state of an illness before Xi'an City, Shanxi Province, medicine, in state of an illness first time at initial stage dispenser, often
Dispenser in 7 days once, is total to dispenser 2 times.3 days after second of dispenser, disease index is investigated respectively and calculates preventive effect within 7 days, 15 days.Experiment
As a result it is as follows：
The chlorine nalidixic bacterium ester of table 13 and active component B and its compounding preventing and treating tomato blight test of pesticide effectiveness
As can be seen from Table 13, chlorine nalidixic bacterium ester is with can effectively prevent and treat tomato blight, preventing and treating effect after active component B and its compounding
Fruit is superior to the preventive effect of single dose, and preventive effect phase is grown, and target crop is had no adverse effects in experiment scope of medication.Simultaneously to tomato
Anthracnose has good preventive effect, and preventive effect is up to more than 96%.
Application Example heptachlor nalidixic bacterium ester and active component B and its compounding preventing and treating rice blast test of pesticide effectiveness
This test arrangement investigates the rice blast state of an illness before Shaanxi Province's Hanzhong City, medicine, in state of an illness first time at initial stage dispenser,
Every dispenser in 7 days once, is total to dispenser 2 times.7 days after second of dispenser, disease index is investigated respectively and calculates preventive effect within 14 days, 30 days.
Experimental result is as follows：
The chlorine nalidixic bacterium ester of table 14 and active component B and its compounding preventing and treating rice blast test of pesticide effectiveness
As can be seen from Table 14, chlorine nalidixic bacterium ester and efficiency preventing and treating rice blast, preventing and treating effect after active component B and its compounding
Fruit is superior to the preventive effect of single dose, and preventive effect phase is grown.Target crop is had no adverse effects in experiment scope of medication.Simultaneously to rice
Banded sclerotial blight, false smut also have good preventive effect, and preventive effect is up to more than 96%.
The chlorine nalidixic bacterium ester of Application Example eight and active component B and its compounding preventing and treating watermelon anthrax test of pesticide effectiveness
This test arrangement investigates the watermelon anthrax state of an illness before Shaanxi Province Dali County, medicine, in state of an illness first time at initial stage dispenser,
Every dispenser in 7 days once, is total to dispenser 2 times.7 days after second of dispenser, disease index is investigated respectively and calculates preventive effect within 14 days, 30 days.
Experimental result is as follows：
The chlorine nalidixic bacterium ester of table 15 and active component B and its compounding preventing and treating watermelon anthrax test of pesticide effectiveness
As can be seen from Table 15, chlorine nalidixic bacterium ester is prevented and treated with can effectively prevent and treat watermelon anthrax after active component B and its compounding
Effect is superior to the preventive effect of single dose, and preventive effect phase is grown.Target crop is had no adverse effects in experiment scope of medication.Simultaneously to west
Melon epidemic disease, powdery mildew also have good preventive effect, and preventive effect is up to more than 96%.
The chlorine nalidixic bacterium ester of Application Example nine and active component B and its compounding preventing and treating alternaria leaf spot of apple test of pesticide effectiveness
This test arrangement investigates the alternaria leaf spot of apple state of an illness before Shaanxi Province's Weinan City, medicine, in state of an illness first time at initial stage
Dispenser, every dispenser in 7 days once, are total to dispenser 2 times.7 days after second of dispenser, disease index is investigated respectively and is calculated within 14 days, 30 days
Preventive effect.Experimental result is as follows：
The chlorine nalidixic bacterium ester of table 16 and active component B and its compounding preventing and treating alternaria leaf spot of apple test of pesticide effectiveness
As can be seen from Table 16, alternaria leaf spot of apple can be effectively prevented and treated after chlorine nalidixic bacterium ester and active component B and its compounding,
Prevention effect is superior to the preventive effect of single dose, and preventive effect phase is grown.Target crop is had no adverse effects in experiment scope of medication.Simultaneously
Also there is good preventive effect to apple mildew, preventive effect is up to more than 96%.
The experiment by different places throughout the country is drawn afterwards, and chlorine nalidixic bacterium ester compounds with Propineb, Carbatene, zineb
The downy mildew in various crop, rice blast, false smut, banded sclerotial blight, powdery mildew, sclerotiniose, anthracnose, epidemic disease, spot are fallen afterwards
The preventive effect of the Common Diseases such as leaf disease, brown spot, white rot, scab, ring spot, rust is 95% on excellent, to prevent in single dose
Effect, synergistic effect are obvious.
Claims (6)
1. a kind of bactericidal composition containing chlorine nalidixic bacterium ester and thiocarbamates, effective active composition be active components A and
Active component B, it is characterised in that：Active components A and active component B weight ratio are 1: 80~60: 1, described active components A
Selected from chlorine nalidixic bacterium ester, active component B is Carbatene.
2. the bactericidal composition according to claim 1 containing chlorine nalidixic bacterium ester and thiocarbamates, it is characterised in that：
Active components A and active component B weight ratio are 1：60~40: 1.
3. the bactericidal composition according to claim 2 containing chlorine nalidixic bacterium ester and thiocarbamates, it is characterised in that：
The weight of chlorine nalidixic bacterium ester and Carbatene ratio is 1: 30~10: 1.
4. according to the bactericidal composition according to any one of claims 1 to 3 containing chlorine nalidixic bacterium ester and thiocarbamates,
It is characterized in that：Composition is made wettable powder, water dispersible granules, suspending agent, aqueous emulsion, microemulsion, suspension emulsion, micro-capsule and hanged
Floating agent or microcapsule suspension-suspendinagent agent.
5. the bactericidal composition according to claim 4 containing chlorine nalidixic bacterium ester and thiocarbamates is used to prevent and treat crop
The purposes of disease.
6. purposes according to claim 5, it is characterised in that：Described disease is downy mildew, rice blast, false smut, line
Rot, powdery mildew, sclerotiniose, anthracnose, epidemic disease, spot defoliation, brown spot, white rot, scab, ring spot or rust.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310139019.XA CN104106582B (en) | 2013-04-20 | 2013-04-20 | A kind of bactericidal composition containing chlorine nalidixic bacterium ester and thiocarbamates |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310139019.XA CN104106582B (en) | 2013-04-20 | 2013-04-20 | A kind of bactericidal composition containing chlorine nalidixic bacterium ester and thiocarbamates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104106582A CN104106582A (en) | 2014-10-22 |
| CN104106582B true CN104106582B (en) | 2018-04-03 |
Family
ID=51703727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310139019.XA Active CN104106582B (en) | 2013-04-20 | 2013-04-20 | A kind of bactericidal composition containing chlorine nalidixic bacterium ester and thiocarbamates |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104106582B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104542661A (en) * | 2015-01-27 | 2015-04-29 | 江苏宝灵化工股份有限公司 | Sterilization composition containing triclopyricarb and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1953662A (en) * | 2004-05-13 | 2007-04-25 | 巴斯福股份公司 | Fungicidal mixtures and novel triazolopyrimidines |
| CN101069511A (en) * | 2006-05-09 | 2007-11-14 | 陶氏农业科学公司 | Stabilized fungus-killing agent composition |
| CN101522677A (en) * | 2006-10-06 | 2009-09-02 | 巴斯夫欧洲公司 | Fungicidal n-heteroaryl-condensed pyridine derivatives and fungicidal compositions |
-
2013
- 2013-04-20 CN CN201310139019.XA patent/CN104106582B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1953662A (en) * | 2004-05-13 | 2007-04-25 | 巴斯福股份公司 | Fungicidal mixtures and novel triazolopyrimidines |
| CN101069511A (en) * | 2006-05-09 | 2007-11-14 | 陶氏农业科学公司 | Stabilized fungus-killing agent composition |
| CN101522677A (en) * | 2006-10-06 | 2009-09-02 | 巴斯夫欧洲公司 | Fungicidal n-heteroaryl-condensed pyridine derivatives and fungicidal compositions |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104106582A (en) | 2014-10-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104161042B (en) | A kind of composition pesticide of fluorine-containing azoles bacterium aniline and methoxy acrylic | |
| CN104938488B (en) | High-efficiency bactericidal composition | |
| CN105191939B (en) | A kind of bactericidal composition | |
| CN103518724B (en) | Bactericidal composition containing fluopyram and methoxyacrylate | |
| CN104137836B (en) | A kind of bactericidal composition of fluorine-containing azoles bacterium aniline and methoxy acrylic | |
| CN104126585B (en) | A kind of combination sterilization composition of fluorine-containing azoles bacterium aniline | |
| CN103651460B (en) | Pesticide composition containing fluorine azole activated ester and methoxy acrylic esters | |
| CN105494345B (en) | A kind of efficient bactericidal composite | |
| CN104106582B (en) | A kind of bactericidal composition containing chlorine nalidixic bacterium ester and thiocarbamates | |
| CN105211082B (en) | A kind of composition pesticide containing dimoxystrobin | |
| CN105284806B (en) | A kind of bactericidal composition containing zoxamide and methoxy acrylic | |
| CN103621562B (en) | A kind of bactericidal composition | |
| CN104012536B (en) | A kind of bactericidal composition of fluorine-containing mepanipyrim and methoxy acrylic | |
| CN104115855B (en) | A kind of efficient bactericidal composite containing chlorine nalidixic bacterium ester | |
| CN105028419B (en) | A kind of bactericidal composition containing Fenarimol | |
| CN104012556B (en) | A kind of bactericidal composition containing fluorine mepanipyrim and thiocarbamates | |
| CN104521978B (en) | A kind of bactericidal composition containing dimoxystrobin | |
| CN104604863B (en) | A kind of bactericidal composition containing dimoxystrobin | |
| CN104412996B (en) | A kind of high-efficient pesticide composition of fluorine-containing ether bacterium amide | |
| CN104757007B (en) | A kind of bactericidal composition containing Hexanaphthene flusulfamide | |
| CN105211063B (en) | A kind of bactericidal composition containing dimoxystrobin and antibioticses | |
| CN104012546B (en) | A kind of efficient bactericidal composite of fluorine-containing mepanipyrim and methoxy acrylic | |
| CN104115854B (en) | A kind of Synergistic bactericidal composition containing chlorine nalidixic bacterium ester | |
| CN105815314B (en) | A kind of bactericidal composition containing metrafenone and methoxy acrylic | |
| CN104719308B (en) | A kind of bactericidal composition of fluorine-containing azoles Acibenzolar |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address | ||
| CP03 | Change of name, title or address |
Address after: 715500 Pucheng high tech Industrial Development Zone, Weinan, Shaanxi Patentee after: SHAANXI MEIBANG PHARMACEUTICAL GROUP Co.,Ltd. Address before: 715500 Shaanxi Pucheng Weinan County agricultural base industrial park Patentee before: Shaanxi Meibang pesticide Co.,Ltd. |
|
| OL01 | Intention to license declared | ||
| OL01 | Intention to license declared |