CN104106582A - Bactericidal composition containing triclopyricarb and thiocarbamate - Google Patents
Bactericidal composition containing triclopyricarb and thiocarbamate Download PDFInfo
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- CN104106582A CN104106582A CN201310139019.XA CN201310139019A CN104106582A CN 104106582 A CN104106582 A CN 104106582A CN 201310139019 A CN201310139019 A CN 201310139019A CN 104106582 A CN104106582 A CN 104106582A
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- bacterium ester
- nalidixic bacterium
- chlorine nalidixic
- active component
- composition containing
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- 239000000203 mixture Substances 0.000 title claims abstract description 44
- 230000000844 anti-bacterial effect Effects 0.000 title claims description 17
- QFNFRZHOXWNWAQ-UHFFFAOYSA-N triclopyricarb Chemical compound COC(=O)N(OC)C1=CC=CC=C1COC1=NC(Cl)=C(Cl)C=C1Cl QFNFRZHOXWNWAQ-UHFFFAOYSA-N 0.000 title abstract 3
- GNVMUORYQLCPJZ-UHFFFAOYSA-M Thiocarbamate Chemical compound NC([S-])=O GNVMUORYQLCPJZ-UHFFFAOYSA-M 0.000 title abstract 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims abstract description 40
- 201000010099 disease Diseases 0.000 claims abstract description 25
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 25
- 239000011717 all-trans-retinol Substances 0.000 claims abstract description 20
- 235000019169 all-trans-retinol Nutrition 0.000 claims abstract description 20
- 239000005823 Propineb Substances 0.000 claims abstract description 18
- KKMLIVYBGSAJPM-UHFFFAOYSA-L propineb Chemical compound [Zn+2].[S-]C(=S)NC(C)CNC([S-])=S KKMLIVYBGSAJPM-UHFFFAOYSA-L 0.000 claims abstract description 18
- 241000894006 Bacteria Species 0.000 claims description 70
- 150000002148 esters Chemical class 0.000 claims description 70
- MHWLWQUZZRMNGJ-UHFFFAOYSA-N nalidixic acid Chemical compound C1=C(C)N=C2N(CC)C=C(C(O)=O)C(=O)C2=C1 MHWLWQUZZRMNGJ-UHFFFAOYSA-N 0.000 claims description 69
- 239000000460 chlorine Substances 0.000 claims description 67
- 229910052801 chlorine Inorganic materials 0.000 claims description 67
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 66
- 239000000375 suspending agent Substances 0.000 claims description 22
- AMHNZOICSMBGDH-UHFFFAOYSA-L zineb Chemical compound [Zn+2].[S-]C(=S)NCCNC([S-])=S AMHNZOICSMBGDH-UHFFFAOYSA-L 0.000 claims description 19
- 235000007164 Oryza sativa Nutrition 0.000 claims description 13
- 239000003094 microcapsule Substances 0.000 claims description 13
- 235000009566 rice Nutrition 0.000 claims description 13
- 241000233679 Peronosporaceae Species 0.000 claims description 12
- 239000000839 emulsion Substances 0.000 claims description 11
- 150000003558 thiocarbamic acid derivatives Chemical class 0.000 claims description 10
- 241000221785 Erysiphales Species 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 7
- 239000004562 water dispersible granule Substances 0.000 claims description 7
- 241000221696 Sclerotinia sclerotiorum Species 0.000 claims description 6
- 239000004530 micro-emulsion Substances 0.000 claims description 6
- 239000000725 suspension Substances 0.000 claims description 6
- 238000009736 wetting Methods 0.000 claims description 6
- 241001530056 Athelia rolfsii Species 0.000 claims description 5
- 206010039509 Scab Diseases 0.000 claims description 5
- 230000035613 defoliation Effects 0.000 claims description 5
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 5
- 241000607479 Yersinia pestis Species 0.000 claims description 2
- 240000007594 Oryza sativa Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 6
- 238000001228 spectrum Methods 0.000 abstract description 2
- 230000001954 sterilising effect Effects 0.000 abstract description 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 2
- 230000000749 insecticidal effect Effects 0.000 abstract 3
- 238000005406 washing Methods 0.000 abstract 1
- 239000002131 composite material Substances 0.000 description 32
- 230000003449 preventive effect Effects 0.000 description 29
- 238000012360 testing method Methods 0.000 description 29
- 239000003814 drug Substances 0.000 description 23
- 230000002195 synergetic effect Effects 0.000 description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
- 239000013530 defoamer Substances 0.000 description 13
- 239000002270 dispersing agent Substances 0.000 description 13
- 241000209094 Oryza Species 0.000 description 12
- 239000008367 deionised water Substances 0.000 description 11
- 229910021641 deionized water Inorganic materials 0.000 description 11
- 239000000575 pesticide Substances 0.000 description 11
- 239000012071 phase Substances 0.000 description 11
- 239000003995 emulsifying agent Substances 0.000 description 10
- 239000002904 solvent Substances 0.000 description 10
- 230000002528 anti-freeze Effects 0.000 description 9
- 239000000080 wetting agent Substances 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 239000002562 thickening agent Substances 0.000 description 8
- 240000008067 Cucumis sativus Species 0.000 description 7
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 7
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 7
- 240000003768 Solanum lycopersicum Species 0.000 description 7
- 239000000463 material Substances 0.000 description 6
- 231100000820 toxicity test Toxicity 0.000 description 6
- 241000219109 Citrullus Species 0.000 description 5
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 description 5
- 206010011732 Cyst Diseases 0.000 description 5
- 206010067482 No adverse event Diseases 0.000 description 5
- 208000031513 cyst Diseases 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 229920002521 macromolecule Polymers 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 241000223600 Alternaria Species 0.000 description 4
- 241000193738 Bacillus anthracis Species 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 239000000945 filler Substances 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 239000003002 pH adjusting agent Substances 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 239000003905 agrochemical Substances 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 230000008485 antagonism Effects 0.000 description 3
- 239000008346 aqueous phase Substances 0.000 description 3
- 238000000498 ball milling Methods 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 239000007884 disintegrant Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 239000012752 auxiliary agent Substances 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 230000000855 fungicidal effect Effects 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- GTCAXTIRRLKXRU-UHFFFAOYSA-N methyl carbamate Chemical compound COC(N)=O GTCAXTIRRLKXRU-UHFFFAOYSA-N 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000010008 shearing Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001018 virulence Effects 0.000 description 2
- -1 3,5,6-trichloropyridine-2-yl Chemical group 0.000 description 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 1
- 241000395107 Cladosporium cucumerinum Species 0.000 description 1
- 241001123534 Colletotrichum coccodes Species 0.000 description 1
- 241000219112 Cucumis Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 102100025287 Cytochrome b Human genes 0.000 description 1
- 102100030497 Cytochrome c Human genes 0.000 description 1
- 108010075028 Cytochromes b Proteins 0.000 description 1
- 108010075031 Cytochromes c Proteins 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000012271 agricultural production Methods 0.000 description 1
- 230000010165 autogamy Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- XCJXQCUJXDUNDN-UHFFFAOYSA-N chlordene Chemical compound C12C=CCC2C2(Cl)C(Cl)=C(Cl)C1(Cl)C2(Cl)Cl XCJXQCUJXDUNDN-UHFFFAOYSA-N 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
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- 239000006185 dispersion Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- FRCCEHPWNOQAEU-UHFFFAOYSA-N heptachlor Chemical compound ClC1=C(Cl)C2(Cl)C3C=CC(Cl)C3C1(Cl)C2(Cl)Cl FRCCEHPWNOQAEU-UHFFFAOYSA-N 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 239000010871 livestock manure Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
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- 230000000241 respiratory effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
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- 238000010998 test method Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 239000004563 wettable powder Substances 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses an insecticidal composition containing triclopyricarb and thiocarbamate. The insecticidal composition comprises an active component A and an active component B, the active component A is triclopyricarb and the active component B is one of propineb, thioneb and zineb, and a weight ratio of the active component A to the active component B is in a range of 1: 80 to 60: 1. The insecticidal composition has high activity to a plurality of diseases of a plurality of crops, produces obvious synergism, enlarges a sterilization spectrum and has the characteristics of small use amount, rainwater washing resistance and obvious synergism.
Description
Technical field
The invention belongs to technical field of pesticide, relate to the application of a kind of bactericidal composition containing chlorine nalidixic bacterium ester and thiocarbamates in crop pest.
Technical background
Chlorine nalidixic bacterium ester: molecular formula is C
15h
13c
l3n
2o
4chemical name is N-methoxyl group-N-[2-[[(3,5,6-trichloropyridine-2-yl) oxygen] methyl] phenyl] methyl carbamate, belong to carbamate fungicide, outward appearance is pale solid, the same with the mechanism of action of other methoxy acrylic bactericide, chlorine nalidixic bacterium ester is also mitochondrial respiratory inhibitor, namely by suppressing the breathing of electronics transfer Mitochondria between cytochrome b and c, causes effect.
In the real process of agricultural production, preventing and treating the problem that disease the most easily produces is the generation of disease drug resistance.Different cultivars composition carries out composite, is to prevent and treat the very common method of resistance disease.Heterogeneity is carried out composite, according to practical application effect, judge certain composite be synergy, add and or antagonism.In most cases, the composite effect of agricultural chemicals is all additive effect, really has the seldom composite of synergistic effect, especially synergistic effect very obviously, synergy ratio very high composite just still less.Through inventor's research, discovery is mutually composite by chlorine nalidixic bacterium ester and Propineb, Carbatene or zineb, there is within the specific limits good synergistic effect, and relevant to Propineb, Carbatene or zineb composite about chlorine nalidixic bacterium ester, there is not yet at present relevant report at home and abroad.
Summary of the invention
The object of the invention is to propose a kind of have synergistic function, use cost is low, preventive effect the is good bactericidal composition containing chlorine nalidixic bacterium ester and thiocarbamates.
The present invention is achieved through the following technical solutions:
A kind of bactericidal composition containing chlorine nalidixic bacterium ester and thiocarbamates, contain active components A and active component B, active components A and active component B weight ratio are 1: 80～60: 1, described active components A is selected from chlorine nalidixic bacterium ester, and active component B is selected from a kind of in Propineb, Carbatene or zineb; The weight ratio that is preferably active components A and active component B is 1 ︰ 60～40 ︰ 1; More preferably the weight ratio of chlorine nalidixic bacterium ester and Propineb is 1: 24～10: 1, and the weight ratio of chlorine nalidixic bacterium ester and Carbatene is 1: 30～10: 1, and the weight ratio of chlorine nalidixic bacterium ester and zineb is 1: 34～10: 1; The weight ratio that most preferably is chlorine nalidixic bacterium ester and Propineb is 1: 19～1: 1, and the weight ratio of chlorine nalidixic bacterium ester and Carbatene is 1: 19～1: 1, and the weight ratio of chlorine nalidixic bacterium ester and zineb is 1: 29～9: 1.
Bactericidal composition of the present invention, can be processed into acceptable formulation in any sterilization on demand, and wherein more preferably formulation is wetting powder, water dispersible granules, suspending agent, aqueous emulsion, microemulsion, microcapsule suspending agent.
The disease of the described bactericidal composition containing chlorine nalidixic bacterium ester and thiocarbamates for preventing and treating crop; Described crop is cereal crops, legume crop, fiber crop, sugar [yielding, melon crop, fruits crop, dry fruit crop, hobby crop, root crop, oil crop, flowers crop, medicinal crop, raw material crop, green manure pasture crop; Described disease is downy mildew, rice blast, false smut, banded sclerotial blight, powdery mildew, stalk break, anthracnose, epidemic disease, spot defoliation, brown spot, white rot, scab, ring spot, rust.
The amount of application when content of active component depends on independent use in bactericidal composition of the present invention, also depends on mixed ratio and the synergistic effect degree of a kind of compound and another kind of compound, and the while is also relevant with target disease.Conventionally in composition, the weight percentage of active component is gross weight 1%～90%, is preferably 5%～80%.According to different preparation types, active component content scope is different.Liquids in general preparation contains 1%～60% active substance by weight, is preferably 5%～50%; Solid pharmaceutical preparation contains 5%～80% active substance by weight, is preferably 10%～80%.
In bactericidal composition of the present invention, at least contain a kind of surfactant, the dispersion of active component in water while being beneficial to use.Surface-active contents is 2%～30% of total formulation weight amount, and surplus is solid or liquid diluent.
Bactericidal composition of the present invention can be by user before use through dilution or directly use.Its preparation can be prepared by processing method known in those skilled in the art, after being about to active component and mixing with liquid flux or solid carrier, then add surfactant as one or more in dispersant, stabilizing agent, wetting agent, binding agent, disintegrant, defoamer etc.According to different dosage form, in preparation, can also contain antifreeze known in those skilled in the art etc.
When making wetting powder, composition comprises following component and content: active components A 0.5%～60%, active component B0.5%～80%, dispersant 1%～12%, wetting agent 1%～8%, filler surplus.
When making water dispersible granules, composition comprises following component and content: active components A 0.5%～60%, active component B0.5%～80%, dispersant 1%～12%, wetting agent 1%～8%, disintegrant 1%～10%, binding agent 0～8%, filler surplus.
When making suspending agent, composition comprises following component and content: active components A 0.5%～50%, active component B0.5%～50%, dispersant 1%～10%, wetting agent 1%～10%, defoamer 0.01%～2%, thickener 0～2%, antifreeze 0～8%, deionized water add to 100%.
When making aqueous emulsion, composition comprises following component and content: active components A 0.5%～50%, active component B0.5%～50%, solvent 1%～20%, emulsifier 1%～12%, antifreeze 0～8%, defoamer 0.01%～2%, thickener 0～2%, deionized water add to 100%.
When making microemulsion, composition comprises following component and content: active components A 0.5%～50%, active component B0.5%～50%, emulsifier 3%～25%, solvent 1%～10%, antifreeze 0～8%, defoamer 0.01%～2%, deionized water add to 100%.
When making suspension emulsion, composition comprises following component and content: active components A 0.5%～50%, active component B0.5%～50%, emulsifier 1%～10%, dispersant 1%～10%, solvent 1%～20%, defoamer 0.01%～2%, thickener 0～2%, antifreeze 0～8%, deionized water add to 100%.
When making microcapsule suspending agent, composition comprises following component and content: active components A 0.5%～50%, active component B0.5%～50%, macromolecule cyst material 1%～10%, dispersant 2%～10%, solvent 1%～10%, emulsifier 1%～7%, pH adjusting agent 0.01%～5%, defoamer 0.01%～2%, deionized water add to 100%.
When making microcapsule suspension-suspending agent, composition comprises following component and content: active components A 0.5%～50%, active component B0.5%～50%, macromolecule cyst material 1%～12%, dispersant 1%～12%, wetting agent 1%～8%, solvent 1%～15%, emulsifier 1%～8%, defoamer 0.01%～2%, thickener 0～2%, pH adjusting agent 0.01%～5%, deionized water add to 100%.
Wetting powder the key technical indexes of the present invention:
Water dispersible granules the key technical indexes of the present invention:
Suspending agent the key technical indexes of the present invention:
Aqueous emulsion the key technical indexes of the present invention:
Microemulsion the key technical indexes of the present invention:
Suspension emulsion the key technical indexes of the present invention:
Microcapsule suspending agent the key technical indexes of the present invention:
Microcapsule suspension-suspending agent the key technical indexes of the present invention:
The invention has the advantages that:
(1) present composition has good synergy and lasting effect within the specific limits, and preventive effect is higher than single dose; (2) agricultural chemicals dosage reduces, and reduces the residual quantity of agricultural chemicals on crop, alleviates environmental pollution; (3) expanded fungicidal spectrum, multiple diseases has been had to greater activity as downy mildew, rice blast, false smut, banded sclerotial blight, powdery mildew, stalk break, anthracnose, epidemic disease, spot defoliation, brown spot, white rot, scab, ring spot, rust etc.
Embodiment
Below in conjunction with embodiment, to further instruction of the present invention, the percentage in embodiment is all weight percentage, but the present invention is not limited thereto.
Application Example one
Embodiment 1～11 wetting powder
Chlorine nalidixic bacterium ester, active component B, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, can be made into wetting powder product of the present invention.Specifically in Table 1.
Table 1 embodiment 1～11 each component and content
Embodiment 12～22 water dispersible granules
Chlorine nalidixic bacterium ester, active component B, dispersant, wetting agent, disintegrant, filler etc. are obtained to the particle diameter needing through air-flow crushing together, then add other auxiliary agents such as binding agent (can add and can not add), obtain the materials of granulating.By item quantitatively send in fluidized bed granulation dryer through granulation and dry after, can make water dispersible granules product of the present invention, specifically in Table 2.
Table 2 embodiment 12～22 each component and content
Propineb, Carbatene, zineb in table 1,2 are exchanged, can make novel formulation.
Embodiment 23～29 suspending agents
By dispersant, wetting agent, defoamer, thickener (can add and can not add), antifreeze (can add and can not add), through high speed shear, mix, add chlorine nalidixic bacterium ester, active component B, in ball mill, ball milling is 2～3 hours, make diameter of particle all below 5 μ m, surplus is supplied by deionized water, can make suspending agent product of the present invention, specifically in Table 3.
Table 3 embodiment 23～29 each component and content
Embodiment 30～34 aqueous emulsions
Chlorine nalidixic bacterium ester, active component B, solvent, emulsifier are added together, make to be dissolved into even oil phase; Deionized water, antifreeze (can add and can not add), thickener (can add and can not add), defoamer are mixed, become homogeneous water.Under high-speed stirred, water is added to oil phase, make aqueous emulsion product of the present invention.Specifically in Table 4.
Table 4 embodiment 30～34 each component and content
Embodiment 35～39 microemulsions
Chlorine nalidixic bacterium ester, active component B are dissolved in the homogenizer that solvent is housed, by emulsifier, antifreeze (can add and can not add), defoamer, join in the homogenizer that above-mentioned solution is housed, surplus gives strong mixing and homogenize after supplying by deionized water, finally obtain the as clear as crystal microemulsion product of the present invention of outward appearance.Specifically in Table 5.
Table 5 embodiment 35～39 each component and content
Carbatene, zineb in table 3～5 are exchanged, can make novel formulation.
Embodiment 40～44 suspension emulsions
Dispersant, defoamer, thickener (can add and can not add), antifreeze (can add and can not add) are mixed through high speed shear, add active component B, in ball mill, ball milling is 2～3 hours, make diameter of particle all below 5 μ m, make active component B suspending agent, then by chlorine nalidixic bacterium ester, emulsifier, solvent and various auxiliary agent with the direct emulsification of high speed agitator in suspending agent, make suspension emulsion product of the present invention.Specifically in Table 6.
Table 6 embodiment 40～44 each component and content
Embodiment 45～47 microcapsule suspending agents
By chlorine nalidixic bacterium ester, active component B, macromolecule cyst material, solvent, make to be dissolved into even oil phase, under shearing condition, oil phase is joined in the aqueous phase solution that contains emulsifier, pH adjusting agent, dispersant, defoamer, surplus is supplied by deionized water, bi-material reacts at oil-water interfaces, forms macromolecule cyst wall, makes the finely disseminated microcapsule suspending agent product of the present composition.Specifically in Table 7.
Table 7 embodiment 45～47 each component and content
Embodiment 48～50 microcapsule suspensions-suspending agent
By active component B, macromolecule cyst material, solvent, make to be dissolved into even oil phase, oil phase is joined in the aqueous phase solution that contains emulsifier, pH adjusting agent under shearing condition, make finely disseminated microcapsule suspending agent.Dispersant, wetting agent, defoamer, thickener (can add and can not add) are mixed through high speed shear, add chlorine nalidixic bacterium ester, in ball mill, ball milling is 2～3 hours, make diameter of particle all below 5 μ m, make suspending agent, then suspending agent is joined in the aqueous phase solution of micro-capsule suspension, deionized water is supplied surplus, makes the finely disseminated microcapsule suspension-suspending agent of present composition product.Specifically in Table 8.
Table 8 embodiment 48～50 each component and content
In table 6～8, active component B is Carbatene or zineb.
The embodiment of the present invention is the method that adopts Toxicity Determination and field trial to combine.First by Toxicity Determination, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR < 0.5 is antagonism, 0.5≤SR≤1.5 are summation action, SR > 1.5 is synergistic effect, on this basis, then carries out field trial.
Test method: after the effective inhibition concentration scope of each medicament is determined in prerun, medicament is established respectively 5 dosage by active constituent content and processed, and establishes clear water contrast.With reference to < < farm-chemical indoor determination test rule bactericide > >, carry out, adopt mycelial growth rate method to measure the virulence of medicament to crop germ.After 72h, by right-angled intersection method, measure colony diameter, calculate and respectively process net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value to (x), with method of least squares, tries to achieve virulence regression equation (y=a+bx), and calculates thus the EC of every kind of medicament
50value.According to Wadley method, calculate the different proportioning synergy ratio (SR) of two medicaments, SR < 0.5 is antagonism simultaneously, and 0.5≤SR≤1.5 are summation action, and SR > 1.5 is synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively active components A and active component B shared ratio in combination;
A is chlorine nalidixic bacterium ester;
B is selected from a kind of in Propineb, Carbatene or zineb.
Application Example two:
For trying disease: cucumber downy mildew, test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd, experimental scheme: effective inhibition concentration scope of determining the two different proportioning mixture of chlorine nalidixic bacterium ester and Propineb through preliminary experiment.
Toxicity test result
The composite toxicity test analysis of results table to cucumber downy mildew of table 9 chlorine nalidixic bacterium ester and Propineb
As shown in Table 9, the proportioning of the composite control cucumber downy mildew of chlorine nalidixic bacterium ester and Propineb is when 1 ︰ 80～60 ︰ 1, synergy ratio SR is all greater than 1.5, illustrate that both are mixed and all show synergistic effect in 1 ︰ 80～60 ︰ 1 scopes, the proportioning of chlorine nalidixic bacterium ester and Propineb was at 1: 24～10: 1, synergistic effect is more outstanding, and synergy ratio is all more than 2.30.Through applicant, test and find that the proportioning of chlorine nalidixic bacterium ester and Propineb is 10 ︰ 1,5 ︰ 1,1 ︰ 1,1 ︰ 5,1 ︰ 6,1 ︰ 7,1 ︰ 8,1 ︰ 9,1 ︰ 10,1 ︰ 11,1 ︰ 12,1 ︰ 13,1 ︰ 14,1 ︰ 15,1 ︰ 16,1 ︰ 17,1 ︰ 18,1 ︰ 19,1 ︰ 20,1 ︰ 21,1 ︰ 22,1 ︰ 23,1 ︰ 24, when wherein chlorine nalidixic bacterium ester and Propineb weight ratio are 1:14, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example three:
For trying disease: rice blast, test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd, experimental scheme: effective inhibition concentration scope of determining the former medicine of chlorine nalidixic bacterium ester and Carbatene and the two different proportioning mixture through preliminary experiment.
Toxicity test result
The composite toxicity test analysis of results table to rice blast of table 10 chlorine nalidixic bacterium ester and Carbatene
As shown in Table 10, the proportioning of the composite control rice blast of chlorine nalidixic bacterium ester and Carbatene is when 1 ︰ 80～60 ︰ 1, synergy ratio SR is all greater than 1.5, illustrate that both are mixed and all show synergistic effect in 1 ︰ 80～60 ︰ 1 scopes, the proportioning of chlorine nalidixic bacterium ester and Carbatene was at 1: 30～10: 1, synergistic effect is more outstanding, and synergy ratio is all more than 2.30.Through applicant, test and find that the proportioning of chlorine nalidixic bacterium ester and Carbatene is 10 ︰ 1,5 ︰ 1,1 ︰ 1,1 ︰ 2,1 ︰ 3,1 ︰ 4,1 ︰ 5,1 ︰ 6,1 ︰ 7,1 ︰ 8,1 ︰ 9,1 ︰ 10,1 ︰ 11,1 ︰ 16,1 ︰ 17,1 ︰ 18,1 ︰ 19,1 ︰ 20,1 ︰ 25,1 ︰ 30, when wherein chlorine nalidixic bacterium ester and Carbatene weight ratio are 1:9, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example four:
For trying disease: tomato blight, test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd, experimental scheme: effective inhibition concentration scope of determining the former medicine of chlorine nalidixic bacterium ester and zineb and the two different proportioning mixture through preliminary experiment.
Toxicity test result
The composite toxicity test analysis of results table to tomato blight of table 11 chlorine nalidixic bacterium ester and zineb
As shown in Table 11, the proportioning of the composite control tomato blight of chlorine nalidixic bacterium ester and zineb is when 1 ︰ 80～60 ︰ 1, synergy ratio SR is all greater than 1.5, illustrate that both are mixed and all show synergistic effect in 1 ︰ 80～60 ︰ 1 scopes, the proportioning of chlorine nalidixic bacterium ester and zineb was at 1: 34～1: 1, synergistic effect is more outstanding, and synergy ratio is all more than 2.30.Through applicant, test and find that the proportioning of chlorine nalidixic bacterium ester and zineb is 1 ︰ 1,1 ︰ 5,1 ︰ 6,1 ︰ 7,1 ︰ 8,1 ︰ 9,1 ︰ 10,1 ︰ 11,1 ︰ 16,1 ︰ 17,1 ︰ 18,1 ︰ 19,1 ︰ 20,1 ︰ 21,1 ︰ 22,1 ︰ 23,1 ︰ 24,1 ︰ 25,1 ︰ 26,1 ︰ 27,1 ︰ 28,1 ︰ 29,1 ︰ 30,1 ︰ 34, when wherein chlorine nalidixic bacterium ester and zineb weight ratio are 1:19, synergy ratio is maximum, and synergistic effect is the most obvious.
Through test, find: after chlorine nalidixic bacterium ester and active component B are composite, the control of the downy mildew in various crop, rice blast, false smut, banded sclerotial blight, powdery mildew, stalk break, anthracnose, epidemic disease, spot defoliation, brown spot, white rot, scab, ring spot, rust is had to obvious synergistic effect, synergy ratio is all more than 1.5.
Effect experiment part: test medicine is researched and developed, provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd, contrast medicament 15% chlorine nalidixic bacterium ester missible oil (autogamy), 70% Wettable propineb powder (commercial), 70% Carbatene water dispersible granules (commercial), 65% Zineb wettable powder (commercial).
Application Example pentachloro-nalidixic bacterium ester and active component B and the composite control cucumber downy mildew test of pesticide effectiveness thereof
This experimental establishment, in Jingyang County, Shaanxi Province, is investigated the cucumber downy mildew state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, once, dispenser is 2 times altogether in dispenser in every 7 days.Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 12 chlorine nalidixic bacterium ester and active component B and the composite control cucumber downy mildew test of pesticide effectiveness thereof
As can be seen from Table 12, chlorine nalidixic bacterium ester and active component B and composite after can effectively prevent and treat cucumber downy mildew, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.Scab of cucumber, powdery mildew, stalk break are also had to good preventive effect, preventive effect is up to more than 96% simultaneously.
Application Example chlordene nalidixic bacterium ester and active component B and the composite control tomato blight test of pesticide effectiveness thereof
This test arrangement, in Xi'an City, Shanxi Province, is investigated the tomato blight state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, once, dispenser is 2 times altogether in dispenser in every 7 days.Within after dispenser 3 days, 7 days, 15 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 13 chlorine nalidixic bacterium ester and active component B and the composite control tomato blight test of pesticide effectiveness thereof
As can be seen from Table 13, chlorine nalidixic bacterium ester and active component B and composite after can effectively prevent and treat tomato blight, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long, in test, target crop is had no adverse effects in scope of medication.Anthracnose of tomato is had to good preventive effect, preventive effect is up to more than 96% simultaneously.
Application Example heptachlor nalidixic bacterium ester and active component B and the composite control rice blast test of pesticide effectiveness thereof
This test arrangement, at Shaanxi Province's Hanzhong City, is investigated the rice blast state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, once, dispenser is 2 times altogether in dispenser in every 7 days.Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 14 chlorine nalidixic bacterium ester and active component B and the composite control rice blast test of pesticide effectiveness thereof
As can be seen from Table 14, chlorine nalidixic bacterium ester and active component B and composite rear efficiency control rice blast thereof, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.Rice sheath blight disease, false smut are also had to good preventive effect, preventive effect is up to more than 96% simultaneously.
Application Example eight chlorine nalidixic bacterium esters and active component B and the composite control watermelon anthrax test of pesticide effectiveness thereof
This test arrangement, in Dali County, Shaanxi Province, is investigated the watermelon anthrax state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, once, dispenser is 2 times altogether in dispenser in every 7 days.Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 15 chlorine nalidixic bacterium ester and active component B and the composite control watermelon anthrax test of pesticide effectiveness thereof
As can be seen from Table 15, chlorine nalidixic bacterium ester and active component B and composite after can effectively prevent and treat watermelon anthrax, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.Watermelon epidemic disease, powdery mildew are also had to good preventive effect, preventive effect is up to more than 96% simultaneously.
Application Example nine chlorine nalidixic bacterium esters and active component B and the composite control alternaria leaf spot of apple test of pesticide effectiveness thereof
This test arrangement, at Shaanxi Province's Weinan City, is investigated the alternaria leaf spot of apple state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, once, dispenser is 2 times altogether in dispenser in every 7 days.Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 16 chlorine nalidixic bacterium ester and active component B and the composite control alternaria leaf spot of apple test of pesticide effectiveness thereof
As can be seen from Table 16, chlorine nalidixic bacterium ester and active component B and composite after can effectively prevent and treat alternaria leaf spot of apple, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.Apple mildew is also had to good preventive effect, preventive effect is up to more than 96% simultaneously.
After through different local throughout the country tests, draw, chlorine nalidixic bacterium ester and Propineb, Carbatene, zineb composite rear to the preventive effect of the Common Diseases such as the downy mildew in various crop, rice blast, false smut, banded sclerotial blight, powdery mildew, stalk break, anthracnose, epidemic disease, spot defoliation, brown spot, white rot, scab, ring spot, rust all 95% with on excellent, in single dose preventive effect, synergistic effect is obvious.
Claims (6)
1. the bactericidal composition containing chlorine nalidixic bacterium ester and thiocarbamates, effective active composition is active components A and active component B, it is characterized in that: the weight ratio of active components A and active component B is 1: 80～60: 1, described active components A is selected from chlorine nalidixic bacterium ester, and active component B is selected from a kind of in Propineb, Carbatene or zineb.
2. the bactericidal composition containing chlorine nalidixic bacterium ester and thiocarbamates according to claim 1, is characterized in that: the weight ratio of active components A and active component B is 1:60～40: 1.
3. the bactericidal composition containing chlorine nalidixic bacterium ester and thiocarbamates according to claim 2, is characterized in that:
The weight ratio of chlorine nalidixic bacterium ester and Propineb is 1: 24～10: 1;
The weight ratio of chlorine nalidixic bacterium ester and Carbatene is 1: 30～10: 1;
The weight ratio of chlorine nalidixic bacterium ester and zineb is 1: 34～10: 1.
4. according to the bactericidal composition containing chlorine nalidixic bacterium ester and thiocarbamates described in any one in claim 1～3, it is characterized in that: composition is made wetting powder, water dispersible granules, suspending agent, aqueous emulsion, microemulsion, suspension emulsion, microcapsule suspending agent or microcapsule suspension-suspending agent.
5. the bactericidal composition containing chlorine nalidixic bacterium ester and thiocarbamates according to claim 4 is for preventing and treating the purposes of crop pest.
6. purposes according to claim 5, is characterized in that: described disease is downy mildew, rice blast, false smut, banded sclerotial blight, powdery mildew, stalk break, anthracnose, epidemic disease, spot defoliation, brown spot, white rot, scab, ring spot or rust.
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| CN1953662A (en) * | 2004-05-13 | 2007-04-25 | 巴斯福股份公司 | Fungicidal mixtures and novel triazolopyrimidines |
| CN101069511A (en) * | 2006-05-09 | 2007-11-14 | 陶氏农业科学公司 | Stabilized fungus-killing agent composition |
| CN101522677A (en) * | 2006-10-06 | 2009-09-02 | 巴斯夫欧洲公司 | Fungicidal n-heteroaryl-condensed pyridine derivatives and fungicidal compositions |
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| CN1953662A (en) * | 2004-05-13 | 2007-04-25 | 巴斯福股份公司 | Fungicidal mixtures and novel triazolopyrimidines |
| CN101069511A (en) * | 2006-05-09 | 2007-11-14 | 陶氏农业科学公司 | Stabilized fungus-killing agent composition |
| CN101522677A (en) * | 2006-10-06 | 2009-09-02 | 巴斯夫欧洲公司 | Fungicidal n-heteroaryl-condensed pyridine derivatives and fungicidal compositions |
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| CN104542661A (en) * | 2015-01-27 | 2015-04-29 | 江苏宝灵化工股份有限公司 | Sterilization composition containing triclopyricarb and application thereof |
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