CN104115855A - Efficient sterilization composition containing SYP-7017 - Google Patents
Efficient sterilization composition containing SYP-7017 Download PDFInfo
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- CN104115855A CN104115855A CN201310147102.1A CN201310147102A CN104115855A CN 104115855 A CN104115855 A CN 104115855A CN 201310147102 A CN201310147102 A CN 201310147102A CN 104115855 A CN104115855 A CN 104115855A
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- bacterium ester
- nalidixic bacterium
- chlorine nalidixic
- active component
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- 239000000203 mixture Substances 0.000 title claims abstract description 41
- 230000001954 sterilising effect Effects 0.000 title abstract description 5
- 238000004659 sterilization and disinfection Methods 0.000 title abstract description 5
- QFNFRZHOXWNWAQ-UHFFFAOYSA-N triclopyricarb Chemical compound COC(=O)N(OC)C1=CC=CC=C1COC1=NC(Cl)=C(Cl)C=C1Cl QFNFRZHOXWNWAQ-UHFFFAOYSA-N 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 claims abstract description 32
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 32
- 239000005780 Fluazinam Substances 0.000 claims abstract description 19
- 239000005782 Fluopicolide Substances 0.000 claims abstract description 19
- 239000005810 Metrafenone Substances 0.000 claims abstract description 19
- UZCGKGPEKUCDTF-UHFFFAOYSA-N fluazinam Chemical compound [O-][N+](=O)C1=CC(C(F)(F)F)=C(Cl)C([N+]([O-])=O)=C1NC1=NC=C(C(F)(F)F)C=C1Cl UZCGKGPEKUCDTF-UHFFFAOYSA-N 0.000 claims abstract description 19
- GBOYJIHYACSLGN-UHFFFAOYSA-N fluopicolide Chemical compound ClC1=CC(C(F)(F)F)=CN=C1CNC(=O)C1=C(Cl)C=CC=C1Cl GBOYJIHYACSLGN-UHFFFAOYSA-N 0.000 claims abstract description 19
- AMSPWOYQQAWRRM-UHFFFAOYSA-N metrafenone Chemical compound COC1=CC=C(Br)C(C)=C1C(=O)C1=C(C)C=C(OC)C(OC)=C1OC AMSPWOYQQAWRRM-UHFFFAOYSA-N 0.000 claims abstract description 19
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- MHWLWQUZZRMNGJ-UHFFFAOYSA-N nalidixic acid Chemical compound C1=C(C)N=C2N(CC)C=C(C(O)=O)C(=O)C2=C1 MHWLWQUZZRMNGJ-UHFFFAOYSA-N 0.000 claims description 85
- 239000000460 chlorine Substances 0.000 claims description 84
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- BBXXLROWFHWFQY-UHFFFAOYSA-N ethirimol Chemical compound CCCCC1=C(C)NC(NCC)=NC1=O BBXXLROWFHWFQY-UHFFFAOYSA-N 0.000 abstract 1
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- -1 3,5,6-trichloropyridine-2-yl Chemical group 0.000 description 7
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- GTCAXTIRRLKXRU-UHFFFAOYSA-N methyl carbamate Chemical compound COC(N)=O GTCAXTIRRLKXRU-UHFFFAOYSA-N 0.000 description 2
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- 241000123650 Botrytis cinerea Species 0.000 description 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 1
- 241000219112 Cucumis Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 102100025287 Cytochrome b Human genes 0.000 description 1
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- 108010075028 Cytochromes b Proteins 0.000 description 1
- 108010075031 Cytochromes c Proteins 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
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- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
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- FRCCEHPWNOQAEU-UHFFFAOYSA-N heptachlor Chemical compound ClC1=C(Cl)C2(Cl)C3C=CC(Cl)C3C1(Cl)C2(Cl)Cl FRCCEHPWNOQAEU-UHFFFAOYSA-N 0.000 description 1
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses an efficient sterilization composition containing SYP-7017. An active ingredient A is SYP-7017, and an active ingredient B is one selected from the group consisting of Metrafenone, ethirimol and salt thereof, fluopicolide, ethaboxam and fluazinam; and the active ingredient A and the active ingredient B are in the weight ratio of 1: 80 to 60: 1 The composition provided by the invention has high activity on a plurality of diseases on a plurality of crops, obvious synergic effect and enlarged sterilization spectrum. In addition, the sterilization composition has the characteristics of small drugs dose, rainwater washing resistance and obvious synergism.
Description
Technical field
The invention belongs to technical field of pesticide, relate to the application of a kind of efficient bactericidal composite containing chlorine nalidixic bacterium ester in crop pest.
Technical background
Chlorine nalidixic bacterium ester: molecular formula is C
15h
13c
l3n
2o
4chemical name is N-methoxyl group-N-[2-[[(3,5,6-trichloropyridine-2-yl) oxygen] methyl] phenyl] methyl carbamate, belong to carbamate fungicide, outward appearance is pale solid, the same with the mechanism of action of other methoxy acrylic bactericide, chlorine nalidixic bacterium ester is also mitochondrial respiratory inhibitor, namely causes effect by the breathing that suppresses electronics transfer Mitochondria between cytochrome b and c.
In the real process of agricultural production, preventing and treating the problem that disease the most easily produces is the generation of disease drug resistance.Different cultivars composition carries out composite, is to prevent and treat the very common method of resistance disease.Heterogeneity is carried out composite, according to practical application effect, judge certain composite be synergy, add and or antagonism.In most cases, the composite effect of agricultural chemicals is all additive effect, really have a synergistic effect composite seldom, especially synergistic effect very obviously, synergy ratio very high composite just still less.Through inventor's research, find mutually composite to chlorine nalidixic bacterium ester and metrafenone, the phonetic phenol of second and salt thereof, fluopicolide, Guardian, fluazinam, there is within the specific limits good synergistic effect, and relevant composite about chlorine nalidixic bacterium ester and metrafenone, the phonetic phenol of second and salt thereof, fluopicolide, Guardian, fluazinam, there is not yet at present relevant report at home and abroad.
Summary of the invention
The object of the invention is to propose a kind of have synergistic function, use cost is low, preventive effect the is good efficient bactericidal composite containing chlorine nalidixic bacterium ester.
The present invention is achieved through the following technical solutions:
A kind of efficient bactericidal composite containing chlorine nalidixic bacterium ester, contain active components A and active component B, active components A and active component B weight ratio are 1: 80～60: 1, described active components A is selected from chlorine nalidixic bacterium ester, and active component B is selected from the one in metrafenone, the phonetic phenol of second and salt, fluopicolide, Guardian or fluazinam; The weight ratio that is preferably active components A and active component B is 1 ︰ 60～40 ︰ 1; More preferably the weight ratio of chlorine nalidixic bacterium ester and metrafenone is 1: 20～15: 1, and the weight ratio of the phonetic phenol of chlorine nalidixic bacterium ester and second and salt, fluopicolide, Guardian or fluazinam is 1: 20～10: 1; The weight ratio that most preferably is chlorine nalidixic bacterium ester and metrafenone is 1: 9～9: 1, and the weight ratio of the phonetic phenol of chlorine nalidixic bacterium ester and second and salt, fluopicolide, Guardian or fluazinam is 1: 9～4: 1.
Bactericidal composition of the present invention, can be processed on demand acceptable formulation in any sterilization, wherein more preferably formulation is wetting powder, water dispersible granules, suspending agent, aqueous emulsion, microemulsion, suspension emulsion, microcapsule suspending agent, microcapsule suspension-suspending agent.
The disease of the described efficient bactericidal composite containing chlorine nalidixic bacterium ester for preventing and treating crop; Described crop is cereal crops, legume crop, fiber crop, sugar [yielding, melon crop, fruits crop, dry fruit crop, hobby crop, root crop, oil crop, flowers crop, medicinal crop, raw material crop, green manure pasture crop; Described disease is downy mildew, epidemic disease, powdery mildew, rice blast, false smut, banded sclerotial blight, damping off, anthracnose, gray mold, stalk break, club root.
The amount of application when content of active component depends on independent use in bactericidal composition of the present invention, also depends on mixed ratio and the synergistic effect degree of a kind of compound and another kind of compound, and the while is also relevant with target disease.Conventionally in composition, the weight percentage of active component is gross weight 1%～90%, is preferably 5%～80%.According to different preparation types, active component content scope is different.Liquids in general preparation contains 1%～60% active substance by weight, is preferably 5%～50%; Solid pharmaceutical preparation contains 5%～80% active substance by weight, is preferably 10%～80%.
In bactericidal composition of the present invention, at least contain a kind of surfactant, the dispersion of active component in water while being beneficial to use.Surface-active contents is 2%～30% of total formulation weight amount, and surplus is solid or liquid diluent.
Bactericidal composition of the present invention can be by user before use through dilution or directly use.Its preparation can be prepared by processing method known in those skilled in the art, after mixing with liquid flux or solid carrier by active component, then add surfactant as one or more in dispersant, stabilizing agent, wetting agent, binding agent, disintegrant, defoamer etc.According to different dosage form, in preparation, can also contain antifreeze known in those skilled in the art etc.
When making wetting powder, composition comprises following component and content: active components A 0.5%～60%, active component B0.5%～80%, dispersant 1%～12%, wetting agent 1%～8%, filler surplus.
When making water dispersible granules, composition comprises following component and content: active components A 0.5%～60%, active component B0.5%～80%, dispersant 1%～12%, wetting agent 1%～8%, disintegrant 1%～10%, binding agent 0～8%, filler surplus.
When making suspending agent, composition comprises following component and content: active components A 0.5%～50%, active component B0.5%～50%, dispersant 1%～10%, wetting agent 1%～10%, defoamer 0.01%～2%, thickener 0～2%, antifreeze 0～8%, deionized water add to 100%.
When making aqueous emulsion, composition comprises following component and content: active components A 0.5%～50%, active component B0.5%～50%, solvent 1%～20%, emulsifier 1%～12%, antifreeze 0～8%, defoamer 0.01%～2%, thickener 0～2%, deionized water add to 100%.
When making microemulsion, composition comprises following component and content: active components A 0.5%～50%, active component B0.5%～50%, emulsifier 3%～25%, solvent 1%～10%, antifreeze 0～8%, defoamer 0.01%～2%, deionized water add to 100%.
When making suspension emulsion, composition comprises following component and content: active components A 0.5%～50%, active component B0.5%～50%, emulsifier 1%～10%, dispersant 1%～10%, solvent 1%～20%, defoamer 0.01%～2%, thickener 0～2%, antifreeze 0～8%, deionized water add to 100%.
When making microcapsule suspending agent, composition comprises following component and content: active components A 0.5%～50%, active component B0.5%～50%, macromolecule cyst material 1%～10%, dispersant 2%～10%, solvent 1%～10%, emulsifier 1%～7%, pH adjusting agent 0.01%～5%, defoamer 0.01%～2%, deionized water add to 100%.
When making microcapsule suspension-suspending agent, composition comprises following component and content: active components A 0.5%～50%, active component B0.5%～50%, macromolecule cyst material 1%～12%, dispersant 1%～12%, wetting agent 1%～8%, solvent 1%～15%, emulsifier 1%～8%, defoamer 0.01%～2%, thickener 0～2%, pH adjusting agent 0.01%～5%, deionized water add to 100%.
Wetting powder the key technical indexes of the present invention:
Water dispersible granules the key technical indexes of the present invention:
Suspending agent the key technical indexes of the present invention:
Aqueous emulsion the key technical indexes of the present invention:
Microemulsion the key technical indexes of the present invention:
Suspension emulsion the key technical indexes of the present invention:
Microcapsule suspending agent the key technical indexes of the present invention:
Microcapsule suspension-suspending agent the key technical indexes of the present invention:
The invention has the advantages that:
(1) present composition has good synergy and lasting effect within the specific limits, and preventive effect is higher than single dose; (2) agricultural chemicals dosage reduces, and reduces the residual quantity of agricultural chemicals on crop, alleviates environmental pollution; (3) expanded fungicidal spectrum, multiple diseases has been had to greater activity as downy mildew, epidemic disease, powdery mildew, rice blast, false smut, banded sclerotial blight, damping off, anthracnose, gray mold, stalk break, club root etc.
Embodiment
Below in conjunction with embodiment, to further instruction of the present invention, the percentage in embodiment is all weight percentage, but the present invention is not limited thereto.
Application Example one
Embodiment 1～17 wetting powder
Chlorine nalidixic bacterium ester, active component B, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, can be made into wetting powder product of the present invention.Specifically in table 1.
The each component of table 1 embodiment 1～17 and content
Embodiment 18～34 water dispersible granules
Chlorine nalidixic bacterium ester, active component B, dispersant, wetting agent, disintegrant, filler etc. are obtained to the particle diameter needing through air-flow crushing together, then add other auxiliary agents such as binding agent (can add and can not add), obtain the materials of granulating.By item quantitatively send in fluidized bed granulation dryer through granulation and dry after, can make water dispersible granules product of the present invention, specifically in table 2.
The each component of table 2 embodiment 18～34 and content
Metrafenone, the phonetic phenol of second and salt thereof, fluopicolide, Guardian, fluazinam in table 1,2 are exchanged, can make novel formulation.
Embodiment 35～51 suspending agents
By dispersant, wetting agent, defoamer, thickener (can add and can not add), antifreeze (can add and can not add), mix through high speed shear, add chlorine nalidixic bacterium ester, active component B, ball milling 2～3 hours in ball mill, make diameter of particle all below 5 μ m, surplus is supplied by deionized water, can make suspending agent product of the present invention, specifically in table 3.
The each component of table 3 embodiment 35～51 and content
Embodiment 52～61 aqueous emulsions
Chlorine nalidixic bacterium ester, active component B, solvent, emulsifier are added together, make to be dissolved into even oil phase; Deionized water, antifreeze (can add and can not add), thickener (can add and can not add), defoamer are mixed, become homogeneous water.Under high-speed stirred, water is added to oil phase, make aqueous emulsion product of the present invention.Specifically in table 4.
The each component of table 4 embodiment 52～61 and content
Embodiment 62～71 microemulsions
Chlorine nalidixic bacterium ester, active component B are dissolved in the homogenizer that solvent is housed, by emulsifier, antifreeze (can add and can not add), defoamer, join in the homogenizer that above-mentioned solution is housed, surplus gives strong mixing and homogenize after supplying by deionized water, finally obtain the as clear as crystal microemulsion product of the present invention of outward appearance.Specifically in table 5.
The each component of table 5 embodiment 62～71 and content
Metrafenone, the phonetic phenol of second, fluopicolide, Guardian, fluazinam in table 3～5 are exchanged, can make novel formulation.
Embodiment 72～74 suspension emulsions
Dispersant, defoamer, thickener (can add and can not add), antifreeze (can add and can not add) are mixed through high speed shear, add active component B, ball milling 2～3 hours in ball mill, make diameter of particle all below 5 μ m, make active component B suspending agent, then by chlorine nalidixic bacterium ester, emulsifier, solvent and various auxiliary agent with the direct emulsification of high speed agitator in suspending agent, make suspension emulsion product of the present invention.Specifically in table 6.
The each component of table 6 embodiment 72～74 and content
Embodiment 75～77 microcapsule suspending agents
By chlorine nalidixic bacterium ester, active component B, macromolecule cyst material, solvent, make to be dissolved into even oil phase, under shearing condition, oil phase is joined in the aqueous phase solution that contains emulsifier, pH adjusting agent, dispersant, defoamer, surplus is supplied by deionized water, bi-material reacts at oil-water interfaces, forms macromolecule cyst wall, makes the finely disseminated microcapsule suspending agent product of the present composition.Specifically in table 7.
The each component of table 7 embodiment 75～77 and content
Embodiment 78～80 microcapsule suspensions-suspending agent
By active component B, macromolecule cyst material, solvent, make to be dissolved into even oil phase, oil phase is joined in the aqueous phase solution that contains emulsifier, pH adjusting agent under shearing condition, make finely disseminated microcapsule suspending agent.Dispersant, wetting agent, defoamer, thickener (can add and can not add) are mixed through high speed shear, add chlorine nalidixic bacterium ester, ball milling 2～3 hours in ball mill, make diameter of particle all below 5 μ m, make suspending agent, then suspending agent is joined in the aqueous phase solution of micro-capsule suspension, deionized water is supplied surplus, makes the finely disseminated microcapsule suspension-suspending agent of present composition product.Specifically in table 8.
The each component of table 8 embodiment 78～80 and content
The embodiment of the present invention is the method that adopts Toxicity Determination and field trial to combine.First by Toxicity Determination, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR < 0.5 is antagonism, 0.5≤SR≤1.5 are summation action, SR > 1.5 is synergistic effect, on this basis, then carries out field trial.
Test method: after the effective inhibition concentration scope of each medicament is determined in prerun, medicament is established respectively 5 dosage processing by active constituent content, establishes clear water contrast.Carry out with reference to " farm-chemical indoor determination test rule bactericide ", adopt mycelial growth rate method to measure the virulence of medicament to crop germ.After 72h, measure colony diameter by right-angled intersection method, calculate each processing net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value to (x), tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates thus the EC of every kind of medicament
50value.Calculate the different proportioning synergy ratios of two medicaments (SR) according to Wadley method, SR < 0.5 is antagonism simultaneously, and 0.5≤SR≤1.5 are summation action, and SR > 1.5 is synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively active components A and active component B shared ratio in combination;
A is chlorine nalidixic bacterium ester;
B is selected from the one in metrafenone, the phonetic phenol of second and salt thereof, fluopicolide, Guardian, fluazinam.
Application Example two:
For trying disease: grape powdery mildew, test medicine provides by Shaanxi Meibang Pesticide Co., Ltd., experimental scheme: effective inhibition concentration scope of determining the two different proportioning mixture of chlorine nalidixic bacterium ester and metrafenone through preliminary experiment.
Toxicity test result
The composite toxicity test analysis of results table to grape powdery mildew of table 9 chlorine nalidixic bacterium ester and metrafenone
As shown in Table 9, the proportioning of the composite control grape powdery mildew of chlorine nalidixic bacterium ester and metrafenone is in the time of 1 ︰ 80～60 ︰ 1, synergy ratio SR is all greater than 1.5, illustrate that both all show synergistic effect at mixture in 1 ︰ 80～60 ︰ 1 scopes, the proportioning of chlorine nalidixic bacterium ester and metrafenone was at 1: 20～15: 1, synergistic effect is more outstanding, and synergy ratio is all more than 2.30.Test and find that the proportioning of chlorine nalidixic bacterium ester and metrafenone is 15 ︰ 1,10 ︰ 1,5 ︰ 1,4 ︰ 1,3 ︰ 1,2 ︰ 1,1 ︰ 1,1 ︰ 2,1 ︰ 3,1 ︰ 4,1 ︰ 5,1 ︰ 6,1 ︰ 7,1 ︰ 8,1 ︰ 9,1 ︰ 10,1 ︰ 11,1 ︰ 12,1 ︰ 13,1 ︰ 14,1 ︰ 15,1 ︰ 20 through applicant, synergy ratio maximum when wherein chlorine nalidixic bacterium ester and metrafenone weight ratio are 3:2, synergistic effect is the most obvious.
Application Example three:
For trying disease: powdery mildew of cucumber, test medicine provides by Shaanxi Meibang Pesticide Co., Ltd., experimental scheme: effective inhibition concentration scope of determining the phonetic phenol of chlorine nalidixic bacterium ester and second and the former medicine of salt and the two different proportioning mixture through preliminary experiment.
Toxicity test result
The composite toxicity test analysis of results table to powdery mildew of cucumber of the phonetic phenol of table 10 chlorine nalidixic bacterium ester and second and salt thereof
As shown in Table 10, the composite proportioning of preventing and treating powdery mildew of cucumber of the phonetic phenol of chlorine nalidixic bacterium ester and second and salt thereof is in the time of 1 ︰ 80～60 ︰ 1, synergy ratio SR is all greater than 1.5, illustrate that both all show synergistic effect at mixture in 1 ︰ 80～60 ︰ 1 scopes, the proportioning of the phonetic phenol of chlorine nalidixic bacterium ester and second and salt thereof was at 1: 20～10: 1, synergistic effect is more outstanding, and synergy ratio is all more than 2.30.Test and find that the proportioning of chlorine nalidixic bacterium ester and the phonetic phenol of second and salt thereof is 10 ︰ 1,5 ︰ 1,4 ︰ 1,3 ︰ 1,2 ︰ 1,1 ︰ 1,1 ︰ 2,1 ︰ 3,1 ︰ 4,1 ︰ 5,1 ︰ 6,1 ︰ 7,1 ︰ 8,1 ︰ 9,1 ︰ 10,1 ︰ 11,1 ︰ 12,1 ︰ 13,1 ︰ 14,1 ︰ 15,1 ︰ 20 through applicant, synergy ratio maximum when wherein the phonetic phenol of chlorine nalidixic bacterium ester and second and salt weight ratio thereof are 2:5, synergistic effect is the most obvious.
Application Example four:
For trying disease: rice blast, test medicine provides by Shaanxi Meibang Pesticide Co., Ltd., experimental scheme: effective inhibition concentration scope of determining the former medicine of chlorine nalidixic bacterium ester and fluopicolide and the two different proportioning mixture through preliminary experiment.
Toxicity test result
The composite toxicity test analysis of results table to rice blast of table 11 chlorine nalidixic bacterium ester and fluopicolide
As shown in Table 11, the proportioning of the composite control rice blast of chlorine nalidixic bacterium ester and fluopicolide is in the time of 1 ︰ 80～60 ︰ 1, synergy ratio SR is all greater than 1.5, illustrate that both all show synergistic effect at mixture in 1 ︰ 80～60 ︰ 1 scopes, the proportioning of chlorine nalidixic bacterium ester and fluopicolide was at 1: 20～10: 1, synergistic effect is more outstanding, and synergy ratio is all more than 2.30.Test and find that the proportioning of chlorine nalidixic bacterium ester and fluopicolide is 10 ︰ 1,5 ︰ 1,4 ︰ 1,3 ︰ 1,2 ︰ 1,1 ︰ 1,1 ︰ 2,1 ︰ 3,1 ︰ 4,1 ︰ 5,1 ︰ 6,1 ︰ 7,1 ︰ 8,1 ︰ 9,1 ︰ 10,1 ︰ 11,1 ︰ 12,1 ︰ 13,1 ︰ 14,1 ︰ 15,1 ︰ 20 through applicant, synergy ratio maximum when wherein chlorine nalidixic bacterium ester and fluopicolide weight ratio are 1:2, synergistic effect is the most obvious.
Application Example five:
For trying disease: cucumber downy mildew, test medicine provides by Shaanxi Meibang Pesticide Co., Ltd., experimental scheme: effective inhibition concentration scope of determining the former medicine of chlorine nalidixic bacterium ester and Guardian and the two different proportioning mixture through preliminary experiment.
Toxicity test result
The composite toxicity test analysis of results table to cucumber downy mildew of table 12 chlorine nalidixic bacterium ester and Guardian
As shown in Table 12, the proportioning of the composite control cucumber downy mildew of chlorine nalidixic bacterium ester and Guardian is in the time of 1 ︰ 80～60 ︰ 1, synergy ratio SR is all greater than 1.5, illustrate that both all show synergistic effect at mixture in 1 ︰ 80～60 ︰ 1 scopes, the proportioning of chlorine nalidixic bacterium ester and Guardian was at 1: 20～10: 1, synergistic effect is more outstanding, and synergy ratio is all more than 2.30.Test and find that the proportioning of chlorine nalidixic bacterium ester and Guardian is 10 ︰ 1,5 ︰ 1,4 ︰ 1,3 ︰ 1,2 ︰ 1,1 ︰ 1,2 ︰ 3,1 ︰ 3,1 ︰ 4,1 ︰ 5,1 ︰ 6,1 ︰ 7,1 ︰ 8,1 ︰ 9,1 ︰ 10,1 ︰ 11,1 ︰ 12,1 ︰ 13,1 ︰ 14,1 ︰ 15,1 ︰ 20 through applicant, synergy ratio maximum when wherein chlorine nalidixic bacterium ester and Guardian weight ratio are 2:3, synergistic effect is the most obvious.
Application Example six:
For trying disease: potato late blight, test medicine provides by Shaanxi Meibang Pesticide Co., Ltd., experimental scheme: effective inhibition concentration scope of determining the former medicine of chlorine nalidixic bacterium ester and fluazinam and the two different proportioning mixture through preliminary experiment.
Toxicity test result
The composite toxicity test analysis of results table to potato late blight of table 13 chlorine nalidixic bacterium ester and fluazinam
As shown in Table 13, the proportioning of the composite control potato late blight of chlorine nalidixic bacterium ester and fluazinam is in the time of 1 ︰ 80～60 ︰ 1, synergy ratio SR is all greater than 1.5, illustrate that both all show synergistic effect at mixture in 1 ︰ 80～60 ︰ 1 scopes, the proportioning of chlorine nalidixic bacterium ester and fluazinam was at 1: 20～10: 1, synergistic effect is more outstanding, and synergy ratio is all more than 2.25.Test and find that the proportioning of chlorine nalidixic bacterium ester and fluazinam is 10 ︰ 1,5 ︰ 1,4 ︰ 1,3 ︰ 1,2 ︰ 1,1 ︰ 1,1 ︰ 2,1 ︰ 3,1 ︰ 4,1 ︰ 5,1 ︰ 6,1 ︰ 7,1 ︰ 8,1 ︰ 9,1 ︰ 10,1 ︰ 11,1 ︰ 12,1 ︰ 13,1 ︰ 14,1 ︰ 15,1 ︰ 20 through applicant, synergy ratio maximum when wherein chlorine nalidixic bacterium ester and fluazinam weight ratio are 1:2, synergistic effect is the most obvious.
Find through test: after chlorine nalidixic bacterium ester and active component B are composite, the control of the downy mildew in various crop, epidemic disease, powdery mildew, rice blast, false smut, banded sclerotial blight, damping off, anthracnose, gray mold, stalk break, club root is had to obvious synergistic effect, synergy ratio is all more than 1.5.
Effect experiment part: test medicine is researched and developed, provided by Shaanxi Meibang Pesticide Co., Ltd., contrast medicament 15% chlorine nalidixic bacterium ester missible oil (autogamy), 20% metrafenone suspending agent (autogamy), the phonetic phenol of 25% second and salt suspension agent (commercial) thereof, 25% fluopicolide suspending agent (autogamy), 12.5% Guardian wetting powder (commercial), 500g/L fluazinam suspending agent (commercial).
Application Example heptachlor nalidixic bacterium ester and active component B and the composite powdery mildew of cucumber test of pesticide effectiveness of preventing and treating thereof
This experimental establishment, in Jingyang County, Shaanxi Province, is investigated the powdery mildew of cucumber state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 14 chlorine nalidixic bacterium ester and active component B and the composite powdery mildew of cucumber test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 14, chlorine nalidixic bacterium ester and active component B and composite after can effectively prevent and treat powdery mildew of cucumber, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.Cucumber damping off, epidemic disease are also had to good preventive effect, preventive effect is up to more than 96% simultaneously.
Application Example eight chlorine nalidixic bacterium esters and active component B and the composite control rice blast test of pesticide effectiveness thereof
This test arrangement, at Shaanxi Province's Hanzhong City, is investigated the rice blast state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 3 days, 7 days, 15 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 15 chlorine nalidixic bacterium ester and active component B and the composite control rice blast test of pesticide effectiveness thereof
As can be seen from Table 15, chlorine nalidixic bacterium ester and active component B and composite after can effectively prevent and treat rice blast, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long, target crop is had no adverse effects in scope of medication in test.Rice green smut, banded sclerotial blight, damping off are also had to good preventive effect, preventive effect is up to more than 96% simultaneously.
Application Example nine chlorine nalidixic bacterium esters and active component B and the composite control capsicum epidemic disease test of pesticide effectiveness thereof
This test arrangement, in Xi'an City, Shanxi Province, is investigated the capsicum epidemic disease state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 16 chlorine nalidixic bacterium ester and active component B and the composite control capsicum epidemic disease test of pesticide effectiveness thereof
As can be seen from Table 16, chlorine nalidixic bacterium ester and active component B and composite rear efficiency control capsicum epidemic disease thereof, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.Botrytis cinerea, anthracnose are also had to good preventive effect, preventive effect is up to more than 96% simultaneously.
Application Example ten chlorine nalidixic bacterium esters and active component B and the composite control cucumber downy mildew test of pesticide effectiveness thereof
This test arrangement, in Xi'an City, Shanxi Province, is investigated the cucumber downy mildew state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 17 chlorine nalidixic bacterium ester and active component B and the composite control cucumber downy mildew test of pesticide effectiveness thereof
As can be seen from Table 17, chlorine nalidixic bacterium ester and active component B and composite after can effectively prevent and treat cucumber downy mildew, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example 11 chlorine nalidixic bacterium esters and active component B and the composite control grape powdery mildew test of pesticide effectiveness thereof
This test arrangement, in Xi'an City, Shanxi Province, is investigated the grape powdery mildew state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 18 chlorine nalidixic bacterium ester and active component B and the composite control grape powdery mildew test of pesticide effectiveness thereof
As can be seen from Table 18, chlorine nalidixic bacterium ester and active component B and composite after can effectively prevent and treat grape powdery mildew, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.Grape grey mould, anthracnose are also had to good preventive effect, preventive effect is up to more than 96% simultaneously.
Application Example 12 chlorine nalidixic bacterium esters and active component B and the composite control cabbage clubroot test of pesticide effectiveness thereof
This test arrangement, in Xi'an City, Shanxi Province, is investigated the cabbage clubroot state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 19 chlorine nalidixic bacterium ester and active component B and the composite control cabbage clubroot test of pesticide effectiveness thereof
As can be seen from Table 19, chlorine nalidixic bacterium ester and active component B and composite after can effectively prevent and treat cabbage clubroot, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example 13 chlorine nalidixic bacterium esters and active component B and the composite control grey mould fruit rot of strawberry test of pesticide effectiveness thereof
This test arrangement, in Xi'an City, Shanxi Province, is investigated the grey mould fruit rot of strawberry state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 20 chlorine nalidixic bacterium ester and active component B and the composite control grey mould fruit rot of strawberry test of pesticide effectiveness thereof
As can be seen from Table 20, chlorine nalidixic bacterium ester and active component B and composite after can effectively prevent and treat grey mould fruit rot of strawberry, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
After draw through different local throughout the country tests, chlorine nalidixic bacterium ester and metrafenone, the phonetic phenol of second and salt thereof, fluopicolide, Guardian, fluazinam composite rear to the preventive effect of the Common Diseases such as the downy mildew in various crop, epidemic disease, powdery mildew, rice blast, false smut, banded sclerotial blight, damping off, anthracnose, gray mold, stalk break, club root all 95% with on excellent, in single dose preventive effect, synergistic effect is obvious.
Claims (6)
1. the efficient bactericidal composite containing chlorine nalidixic bacterium ester, effective active composition is active components A and active component B, it is characterized in that: the weight ratio of active components A and active component B is 1: 80～60: 1, described active components A is selected from chlorine nalidixic bacterium ester, and active component B is selected from the one in metrafenone, the phonetic phenol of second and salt, fluopicolide, Guardian or fluazinam.
2. the efficient bactericidal composite containing chlorine nalidixic bacterium ester according to claim 1, is characterized in that: the weight ratio of active components A and active component B is 1:60～40: 1.
3. the efficient bactericidal composite containing chlorine nalidixic bacterium ester according to claim 2, is characterized in that:
The weight ratio of chlorine nalidixic bacterium ester and metrafenone is 1: 20～15: 1;
The weight ratio of the phonetic phenol of chlorine nalidixic bacterium ester and second and salt, fluopicolide, Guardian or fluazinam is 1: 20～10: 1.
4. according to the efficient bactericidal composite containing chlorine nalidixic bacterium ester described in any one in claim 1～3, it is characterized in that: composition is made wetting powder, water dispersible granules, suspending agent, aqueous emulsion, microemulsion, suspension emulsion, microcapsule suspending agent or microcapsule suspension-suspending agent.
5. the efficient bactericidal composite containing chlorine nalidixic bacterium ester according to claim 4 is for preventing and treating the purposes of crop pest.
6. purposes according to claim 5, is characterized in that: described disease is downy mildew, epidemic disease, powdery mildew, rice blast, false smut, banded sclerotial blight, damping off, anthracnose, gray mold, stalk break or club root.
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| CN107197873A (en) * | 2017-06-13 | 2017-09-26 | 江苏省绿盾植保农药实验有限公司 | A kind of composition pesticide and its application containing chlorine nalidixic bacterium ester and fluazinam |
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| CN101822259A (en) * | 2010-01-27 | 2010-09-08 | 深圳诺普信农化股份有限公司 | Sterilization compound containing ZJ0712 |
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