CN104336023A - Sterilization composition containing oxathiapiprolin - Google Patents
Sterilization composition containing oxathiapiprolin Download PDFInfo
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- CN104336023A CN104336023A CN201310343719.0A CN201310343719A CN104336023A CN 104336023 A CN104336023 A CN 104336023A CN 201310343719 A CN201310343719 A CN 201310343719A CN 104336023 A CN104336023 A CN 104336023A
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Abstract
A disclosed compound sterilization composition containing oxathiapiprolin comprises an active component A and an active component B according to the weight ratio of 1:80-80:1, the active component A is oxathiapiprolin, and the active component B is selected from any one of the following compounds: iprodione, acibenzolar, fluazinam, PEIP, fluopicolide and ethaboxam. The composition has synergic effect on multiple disease harmful to agricultural production, helps to reduce usage amount of pesticides, reduce residual quantity of pesticides on crops and mitigate environmental pollution, is safe to people and livestock and good in environment compatibility, and does not easily enable crops to generate drug resistance.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of application of bactericidal composition on corps diseases of fluorine-containing thiazole pyrrole ethyl ketone.
Background technology
Iprodione, Acibenzolar, fluazinam, pyridine bacterium amine, fluopicolide or Guardian all belong to common fungicide, are widely used in the disease of crops.
But in the real process of agricultural production, the problem that controlling disease the most easily produces is the generation of disease drug resistance.Different cultivars composition carries out composite, is to prevent and treat the very common method of resistance disease.Heterogeneity is carried out composite, according to practical application effect, judge certain composite be synergy, add and or antagonism.In most cases, the composite effect of sterilization is all additive effect, really has the seldom composite of synergistic effect, especially synergistic effect clearly, very high composite just less of synergy ratio.Study through inventor, find by fluorine thiazole pyrrole ethyl ketone and iprodione, Acibenzolar, fluazinam, pyridine bacterium amine, fluopicolide or Guardian composite after can produce good synergistic effect, and about fluorine thiazole pyrrole ethyl ketone and the composite relevant report of iprodione, Acibenzolar, fluazinam, pyridine bacterium amine, fluopicolide or Guardian not yet open.
Summary of the invention
The object of the invention is to propose a kind of bactericidal composition with synergistic function, use cost is low, preventive effect is good fluorine-containing thiazole pyrrole ethyl ketone.
The bactericidal composition of the fluorine-containing thiazole pyrrole ethyl ketone that the present invention proposes contains active components A and active component B, active components A and active component B weight ratio are 1 ︰ 80 ~ 80 ︰ 1, described active components A is selected from fluorine thiazole pyrrole ethyl ketone, active component B is selected from the one in iprodione, Acibenzolar, fluazinam, pyridine bacterium amine, fluopicolide or Guardian, and active components A and the preferred weight ratio of active component B are 1 ︰ 50 ~ 50 ︰ 1; The weight ratio being more preferably fluorine thiazole pyrrole ethyl ketone and iprodione is 15:1 ~ 1:25, the weight ratio of fluorine thiazole pyrrole ethyl ketone and Acibenzolar is 30:1 ~ 1:10, the weight ratio of fluorine thiazole pyrrole ethyl ketone and fluazinam is 20:1 ~ 1:20, the weight ratio of fluorine thiazole pyrrole ethyl ketone and pyridine bacterium amine is 25:1 ~ 1:15, the weight ratio of fluorine thiazole pyrrole ethyl ketone and fluopicolide is 20:1 ~ 1:20, and the weight ratio of fluorine thiazole pyrrole ethyl ketone and Guardian is 20:1 ~ 1:20; The weight ratio most preferably being fluorine thiazole pyrrole ethyl ketone and iprodione is 4:1 ~ 1:14, the weight ratio of fluorine thiazole pyrrole ethyl ketone and Acibenzolar is 19:1 ~ 1:1, the weight ratio of fluorine thiazole pyrrole ethyl ketone and fluazinam is 9:1 ~ 1:9, the weight ratio of fluorine thiazole pyrrole ethyl ketone and pyridine bacterium amine is 14:1 ~ 1:4, the weight ratio of fluorine thiazole pyrrole ethyl ketone and fluopicolide is 9:1 ~ 1:9, and the weight ratio of fluorine thiazole pyrrole ethyl ketone and Guardian is 9:1 ~ 1:9.
The bactericidal composition of the fluorine-containing thiazole pyrrole ethyl ketone that the present invention proposes is for preventing and treating the purposes of disease on crops, and described crops comprise cereal crops, legume crop, fiber crop, sugar [yielding, melon crop, fruits crop, dry fruit crop, hobby crop, root crop, oil crop, flower crop, medicinal crop, crop, green manure pasture crop; Described disease comprises gray mold, epidemic disease, spot defoliation, brown spot, zonate spot, crown rot, spike rot, stalk break, powdery mildew, rust, head mold disease, club root, rice blast, damping off or downy mildew.
The weight ratio of active components A, active component B is 1 ︰ 80 ~ 80 ︰ 1.In usual composition, the weight percentage of active component is 0.5% ~ 90% of gross weight, is preferably 5% ~ 80%.According to different preparation types, active component content scope is different.Usually, liquid preparation contains the active substance of by weight 1% ~ 70%, is preferably 5% ~ 50%; Solid pharmaceutical preparation contains the active substance of by weight 5% ~ 80%, is preferably 10% ~ 80%.
At least containing a kind of surfactant in bactericidal composition of the present invention, the dispersion of active component in water when being beneficial to use.Surface-active contents is 5% ~ 30% of total formulation weight amount, and surplus is solid or liquid diluent.
Bactericidal composition of the present invention can by user before use through diluting or directly using.Its preparation can be prepared by common processing method known in those skilled in the art, after mixing with liquid flux or solid carrier by active substance, then add surfactant as one or more in dispersant, stabilizing agent, wetting agent, binding agent, defoamer, disintegrant, antifreeze etc.
Bactericidal composition of the present invention, acceptable formulation in any sterilization can be processed on demand, wherein more preferably formulation is wetting powder, water dispersible granules, suspending agent, oil-suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent or microcapsule suspension-suspendinagent agent, can also make seed coat agent, plant clothing suspending agent.
Composition comprises following constituent content when making wetting powder: active components A 1% ~ 80%, active component B1% ~ 80%, dispersant 2% ~ 10%, wetting agent 2% ~ 10%, filler surplus.
Composition comprises following constituent content when making water dispersible granules: active components A 0.5% ~ 80%, active component B0.5% ~ 80%, dispersant 3% ~ 12%, wetting agent 1% ~ 8%, disintegrant 1% ~ 10%, binding agent 0 ~ 8%, filler surplus.
Composition comprises following constituent content when making suspending agent or oil-suspending agent: active components A 0.1% ~ 50%, active component B0.1% ~ 50%, dispersant 2% ~ 10%, wetting agent 2% ~ 10%, defoamer 0.01% ~ 2%, thickener 0 ~ 2%, antifreeze 0 ~ 8%, deionized water or vegetable oil add to 100%.
Composition comprises following constituent content when making suspension emulsion: active components A 0.1% ~ 50%, active component B0.1% ~ 50%, dispersant 2% ~ 10%, defoamer 0.01% ~ 2%, solvent 1% ~ 15%, thickener 0 ~ 2%, emulsifier 2% ~ 12%, antifreeze 0 ~ 8%, deionized water add to 100%.
Composition comprises following constituent content when making aqueous emulsion: active components A 0.5% ~ 50%, active component B0.5% ~ 50%, solvent 1% ~ 30%, emulsifier 1% ~ 15%, antifreeze 0 ~ 8%, thickener 0 ~ 2%, defoamer 0.01% ~ 2%, deionized water supply surplus.
Composition comprises following constituent content when making microemulsion: active components A 0.1% ~ 50%, active component B0.1% ~ 50%, solvent 1% ~ 30%, emulsifier 3% ~ 25%, antifreeze 0 ~ 8%, defoamer 0.01% ~ 2%, deionized water supply surplus.
Composition comprises following constituent content when making microcapsule suspending agent: active components A 0.1% ~ 50%, active component B0.1% ~ 50%, macromolecule cyst material 2% ~ 10%, dispersant 1% ~ 10%, organic solvent 1% ~ 10%, emulsifier 1% ~ 7%, defoamer 0.01% ~ 2%, pH adjusting agent 0.01% ~ 5%, deionized water add to 100%.
Composition comprises following constituent content when making microcapsule suspension-suspendinagent agent: active components A 0.1% ~ 50%, active component B0.1% ~ 50%, macromolecule cyst material 2% ~ 10%, dispersant 1% ~ 12%, wetting agent 1% ~ 8%, organic solvent 1% ~ 15%, emulsifier 1% ~ 6%, defoamer 0.01% ~ 2%, thickener 0 ~ 2%, pH adjusting agent 0.01% ~ 5%, deionized water add to 100%;
Wetting powder the key technical indexes of the present invention:
Water dispersible granules the key technical indexes of the present invention:
Suspending agent the key technical indexes of the present invention:
Suspension emulsion the key technical indexes of the present invention:
Aqueous emulsion the key technical indexes of the present invention:
Microemulsion the key technical indexes of the present invention:
Microcapsule suspending agent the key technical indexes of the present invention:
Microcapsule suspension-suspendinagent agent the key technical indexes of the present invention:
The invention has the advantages that:
(1) fluorine thiazole pyrrole ethyl ketone and iprodione, Acibenzolar, fluazinam, pyridine bacterium amine, fluopicolide or Guardian composite after, there is obvious synergy and lasting effect; (2) all greater activity is had to the disease on cereal crops, legume crop, fiber crop, sugar [yielding, melon crop, fruits crop, dry fruit crop, hobby crop, root crop, oil crop, flower crop, medicinal crop, crop, green manure pasture crop; (3) decrease pesticide usage amount, reduce the residual quantity of agricultural chemicals on crop, alleviate environmental pollution; (4) to person poultry safety, Environmental compatibility is good; And preparation adhesion strength strengthens, resistance of rainwater washing against.
Embodiment
Below in conjunction with embodiment to further instruction of the present invention, the percentage in embodiment is all weight percentage, but the present invention is not limited thereto.
Application Example one
Embodiment 1 ~ 17 wetting powder
Fluorine thiazole pyrrole ethyl ketone, active component B, dispersant, wetting agent, filler are mixed in mixed cylinder, mixes again after airslide disintegrating mill is pulverized, wetting powder product of the present invention can be obtained, specifically in table 1.
The each component of table 1 embodiment 1 ~ 17 and weight portion
Embodiment 18 ~ 34 water dispersible granules
Fluorine thiazole pyrrole ethyl ketone, active component B, dispersant, wetting agent, disintegrant, filler etc. are obtained together the particle diameter needed through air-flow crushing, then add other auxiliary agents such as binding agent (can add and can not add), obtain granulation materials.Item is quantitatively sent in fluidized bed granulating dryer through granulating and after drying, water dispersible granules product of the present invention can being obtained, specifically in table 2.
The each component of table 2 embodiment 18 ~ 34 and weight portion
Embodiment 35 ~ 51 suspending agent or oil-suspending agent
By dispersant, wetting agent, defoamer, thickener (can add and can not add), antifreeze (can add and can not add), mix through high speed shear, add fluorine thiazole pyrrole ethyl ketone, active component B, ball milling 2 ~ 3 hours in ball mill, make diameter of particle all below 5 μm, surplus deionized water or vegetable oil are supplied, and can obtain suspending agent of the present invention or oil-suspending agent product, specifically in table 3.
The each component of table 3 embodiment 35 ~ 51 and weight portion
Embodiment 52 ~ 62 suspension emulsion
Dispersant, defoamer, thickener (can add and can not add), antifreeze (can add and can not add) are mixed through high speed shear, add active component B, ball milling 2 ~ 3 hours in ball mill, make diameter of particle all below 5 μm, obtained active component B suspending agent, then by fluorine thiazole pyrrole ethyl ketone, solvent, emulsifier and the direct emulsification of various auxiliary agent high speed agitators in suspending agent, surplus deionized water is supplied, obtained suspension emulsion product of the present invention, specifically in table 4.
The each component of table 4 embodiment 52 ~ 62 and weight portion
Embodiment 63 ~ 73 aqueous emulsion
Fluorine thiazole pyrrole ethyl ketone, active component B, solvent, emulsifier are added together, make to be dissolved into homogeneous oil phase; Deionized water, antifreeze (can add and can not add), thickener (can add and can not add), defoamer are mixed, becomes homogeneous aqueous phase.Under high velocity agitation, aqueous phase is added oil phase, surplus deionized water is supplied; Aqueous emulsion product of the present invention can be obtained, specifically in table 5.
The each component of table 5 embodiment 63 ~ 73 and weight portion
Iprodione, Acibenzolar, fluazinam, pyridine bacterium amine, fluopicolide or Guardian in table 1 ~ 5 are exchanged, can novel formulation be obtained.
Embodiment 74,75 microemulsion
Fluorine thiazole pyrrole ethyl ketone, active component B, solvent, emulsifier, antifreeze (can add and can not add), defoamer are fully mixed into the oil phase of homogeneous transparent, under agitation slowly add deionized water, form WO emulsion, again through agitating heating, make it rapid phase inversion and become oil-in-water type, be chilled to room temperature to make it to reach balance, after filtration, surplus deionized water is supplied; Microemulsion product of the present invention can be obtained, specifically in table 6.
Table 6 embodiment 74,75 each component and weight portion
Embodiment 76,77 microcapsule suspending agent
By fluorine thiazole pyrrole ethyl ketone, active component B, macromolecule cyst material, solvent, make to be dissolved into homogeneous oil phase, in a shear condition, oil phase is joined in the aqueous phase solution containing emulsifier, pH adjusting agent, dispersant, surplus deionized water is supplied, bi-material reacts at oil-water interfaces, forms macromolecule cyst wall, makes the finely disseminated microcapsule suspending agent product of the present composition.Specifically in table 7.
Table 7 embodiment 76,77 each component and weight portion
Embodiment 78,79 microcapsule suspension-suspendinagent agent
By fluorine thiazole pyrrole ethyl ketone, macromolecule cyst material, solvent, make to be dissolved into homogeneous oil phase, oil phase is joined in a shear condition in the aqueous phase solution containing emulsifier, pH adjusting agent, make finely disseminated microcapsule suspending agent.Dispersant, wetting agent, defoamer, thickener (can add and can not add) are mixed through high speed shear, add active component B, ball milling 2 ~ 3 hours in ball mill, make diameter of particle all below 5 μm, obtained suspending agent, then join in the aqueous phase solution of micro-capsule suspension by suspending agent, deionized water supplies surplus, make the finely disseminated microcapsule suspension-suspendinagent agent product of the present composition, specifically in table 8.
Table 8 embodiment 78,79 each component and weight portion
The embodiment of the present invention is the method adopting Toxicity Determination and field trial to combine.First by Toxicity Determination, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR < 0.5 is antagonism, 0.5≤SR≤1.5 are summation action, SR > 1.5 is synergistic effect, on this basis, then carries out field trial.
Test method: determine that after the effective inhibition concentration scope of each medicament, medicament establishes 5 dosage process respectively by active constituent content through prerun, if clear water contrast.Carry out with reference to " farm-chemical indoor determination test rule bactericide ", adopt mycelial growth rate method to measure medicament to the virulence of crop germ.Measure colony diameter by right-angled intersection method after 72h, calculate each process net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value to (x), tries to achieve virulence regression equation (y=a+bx), and calculate the EC of often kind of medicament thus with method of least squares
50value.Calculate two medicament different ratio synergies ratio (SR) according to Wadley method, SR < 0.5 is antagonism, and 0.5≤SR≤1.5 are summation action simultaneously, and SR > 1.5 is synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively active components A and the ratio of active component B shared by combination;
A is fluorine thiazole pyrrole ethyl ketone;
B choosing is to the one in iprodione, Acibenzolar, fluazinam, pyridine bacterium amine, fluopicolide or Guardian.
Application Example two
For examination disease: graw mold of tomato
Test medicine provides by Shaanxi Meibang Pesticide Co., Ltd..
Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination fluorine thiazole pyrrole ethyl ketone and the former medicine of iprodione and the two different ratio mixture.
Table 9 fluorine thiazole pyrrole ethyl ketone and iprodione are to the toxicity test analysis of results table of graw mold of tomato
As shown in Table 9, fluorine thiazole pyrrole ethyl ketone and iprodione proportioning are all greater than 1.5 when 1 ︰ 80 ~ 80 ︰ 1 to the synergy ratio SR of graw mold of tomato, both explanations mixture in 1 ︰ 80 ~ 80 ︰ 1 scope all shows synergistic effect, when the proportioning of fluorine thiazole pyrrole ethyl ketone and iprodione is at 15:1 ~ 1:25, synergistic effect is more outstanding, synergy ratio all more than 2.30, when the proportioning of fluorine thiazole pyrrole ethyl ketone and iprodione is at 4:1 ~ 1:14, synergistic effect is the most outstanding, and synergy ratio is all more than 2.40.Testing through applicant the optimum ratio finding fluorine thiazole pyrrole ethyl ketone and iprodione is 15 ︰ 1, 14 ︰ 1, 13 ︰ 1, 12 ︰ 1, 11 ︰ 1, 10 ︰ 1, 9 ︰ 1, 8 ︰ 1, 7 ︰ 1, 6 ︰ 1, 5 ︰ 1, 4 ︰ 1, 3 ︰ 1, 2 ︰ 1, 1 ︰ 1, 1 ︰ 2, 1 ︰ 3, 1 ︰ 4, 1 ︰ 5, 1 ︰ 6, 1 ︰ 7, 1 ︰ 8, 1 ︰ 9, 1 ︰ 10, 1 ︰ 11, 1 ︰ 12, 1 ︰ 13, 1 ︰ 14, 1 ︰ 15, 1 ︰ 16, 1 ︰ 17, 1 ︰ 18, 1 ︰ 19, 1 ︰ 20, 1 ︰ 21, 1 ︰ 22, 1 ︰ 23, 1 ︰ 24, during 1 ︰ 25, especially when fluorine thiazole pyrrole ethyl ketone and iprodione weight ratio are 1:5, synergy ratio is maximum, synergistic effect is the most obvious.
Application Example three
For examination disease: downy mildew of garpe
Test medicine provides by Shaanxi Meibang Pesticide Co., Ltd..
Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination fluorine thiazole pyrrole ethyl ketone and the former medicine of Acibenzolar and the two different ratio mixture.
Table 10 fluorine thiazole pyrrole ethyl ketone and the composite toxicity test analysis of results table to downy mildew of garpe of Acibenzolar
As shown in Table 10, fluorine thiazole pyrrole ethyl ketone and Acibenzolar proportioning are all greater than 1.5 when 1 ︰ 80 ~ 80 ︰ 1 to the synergy ratio SR of downy mildew of garpe, both explanations mixture in 1 ︰ 80 ~ 80 ︰ 1 scope all shows synergistic effect, when the proportioning of fluorine thiazole pyrrole ethyl ketone and Acibenzolar is at 30:1 ~ 1:10, synergistic effect is more outstanding, synergy ratio all more than 2.25, when the proportioning of fluorine thiazole pyrrole ethyl ketone and Acibenzolar is at 19:1 ~ 1:1, synergistic effect is the most outstanding, and synergy ratio is all more than 2.45.Testing through applicant the optimum ratio finding fluorine thiazole pyrrole ethyl ketone and Acibenzolar is 30 ︰ 1, 29 ︰ 1, 28 ︰ 1, 27 ︰ 1, 26 ︰ 1, 25 ︰ 1, 24 ︰ 1, 23 ︰ 1, 22 ︰ 1, 21 ︰ 1, 20 ︰ 1, 19 ︰ 1, 18 ︰ 1, 17 ︰ 1, 16 ︰ 1, 15 ︰ 1, 14 ︰ 1, 13 ︰ 1, 12 ︰ 1, 11 ︰ 1, 10 ︰ 1, 9 ︰ 1, 8 ︰ 1, 7 ︰ 1, 6 ︰ 1, 5 ︰ 1, 4 ︰ 1, 3 ︰ 1, 2 ︰ 1, 1 ︰ 1, 1 ︰ 2, 1 ︰ 3, 1 ︰ 4, 1 ︰ 5, 1 ︰ 6, 1 ︰ 7, 1 ︰ 8, 1 ︰ 9, during 1 ︰ 10, especially when fluorine thiazole pyrrole ethyl ketone and Acibenzolar weight ratio are 8:1, synergy ratio is maximum, synergistic effect is the most obvious.
Application Example four
For examination disease: capsicum epidemic disease
Test medicine provides by Shaanxi Meibang Pesticide Co., Ltd..
Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination fluorine thiazole pyrrole ethyl ketone and the former medicine of fluazinam and the two different ratio mixture.
Table 11 fluorine thiazole pyrrole ethyl ketone and the composite toxicity test analysis of results table to capsicum epidemic disease of fluazinam
As shown in Table 11, fluorine thiazole pyrrole ethyl ketone and fluazinam proportioning are all greater than 1.5 when 1 ︰ 80 ~ 80 ︰ 1 to the synergy ratio SR of capsicum epidemic disease, both explanations mixture in 1 ︰ 80 ~ 80 ︰ 1 scope all shows synergistic effect, when the proportioning of fluorine thiazole pyrrole ethyl ketone and fluazinam is at 20:1 ~ 1:20, synergistic effect is more outstanding, synergy ratio all more than 2.20, when the proportioning of fluorine thiazole pyrrole ethyl ketone and fluazinam is at 9:1 ~ 1:9, synergistic effect is the most outstanding, and synergy ratio is all more than 2.40.Testing through applicant the optimum ratio finding fluorine thiazole pyrrole ethyl ketone and fluazinam is 20 ︰ 1, 19 ︰ 1, 18 ︰ 1, 17 ︰ 1, 16 ︰ 1, 15 ︰ 1, 14 ︰ 1, 13 ︰ 1, 12 ︰ 1, 11 ︰ 1, 10 ︰ 1, 9 ︰ 1, 8 ︰ 1, 7 ︰ 1, 6 ︰ 1, 5 ︰ 1, 4 ︰ 1, 3 ︰ 1, 2 ︰ 1, 1 ︰ 1, 1 ︰ 2, 1 ︰ 3, 1 ︰ 4, 1 ︰ 5, 1 ︰ 6, 1 ︰ 7, 1 ︰ 8, 1 ︰ 9, 1 ︰ 10, 1 ︰ 11, 1 ︰ 12, 1 ︰ 13, 1 ︰ 14, 1 ︰ 15, 1 ︰ 16, 1 ︰ 17, 1 ︰ 18, 1 ︰ 19, during 1 ︰ 20, especially when fluorine thiazole pyrrole ethyl ketone and fluazinam weight ratio are 1:1, synergy ratio is maximum, synergistic effect is the most obvious.
Application Example five
For examination disease: grape grey mould
Test medicine provides by Shaanxi Meibang Pesticide Co., Ltd..
Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination fluorine thiazole pyrrole ethyl ketone and the former medicine of pyridine bacterium amine and the two different ratio mixture.
Table 12 fluorine thiazole pyrrole ethyl ketone and the composite toxicity test analysis of results table to grape grey mould of pyridine bacterium amine
As shown in Table 12, fluorine thiazole pyrrole ethyl ketone and pyridine bacterium amine proportioning are all greater than 1.5 when 1 ︰ 80 ~ 80 ︰ 1 to the synergy ratio SR of grape grey mould, both explanations mixture in 1 ︰ 80 ~ 80 ︰ 1 scope all shows synergistic effect, when the proportioning of fluorine thiazole pyrrole ethyl ketone and pyridine bacterium amine is at 25:1 ~ 1:15, synergistic effect is more outstanding, synergy ratio all more than 2.25, when the proportioning of fluorine thiazole pyrrole ethyl ketone and pyridine bacterium amine is at 14:1 ~ 1:4, synergistic effect is the most outstanding, and synergy ratio is all more than 2.40.Testing through applicant the optimum ratio finding fluorine thiazole pyrrole ethyl ketone and pyridine bacterium amine is 25 ︰ 1, 24 ︰ 1, 23 ︰ 1, 22 ︰ 1, 21 ︰ 1, 20 ︰ 1, 19 ︰ 1, 18 ︰ 1, 17 ︰ 1, 16 ︰ 1, 15 ︰ 1, 14 ︰ 1, 13 ︰ 1, 12 ︰ 1, 11 ︰ 1, 10 ︰ 1, 9 ︰ 1, 8 ︰ 1, 7 ︰ 1, 6 ︰ 1, 5 ︰ 1, 4 ︰ 1, 3 ︰ 1, 2 ︰ 1, 1 ︰ 1, 1 ︰ 2, 1 ︰ 3, 1 ︰ 4, 1 ︰ 5, 1 ︰ 6, 1 ︰ 7, 1 ︰ 8, 1 ︰ 9, 1 ︰ 10, 1 ︰ 11, 1 ︰ 12, 1 ︰ 13, 1 ︰ 14, during 1 ︰ 15, especially when fluorine thiazole pyrrole ethyl ketone and pyridine bacterium amine weight ratio are 6:1, synergy ratio is maximum, synergistic effect is the most obvious.
Application Example six
For examination disease: cucumber downy mildew
Test medicine provides by Shaanxi Meibang Pesticide Co., Ltd..
Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination fluorine thiazole pyrrole ethyl ketone and the former medicine of fluopicolide and the two different ratio mixture.
Table 13 fluorine thiazole pyrrole ethyl ketone and the composite toxicity test analysis of results table to cucumber downy mildew of fluopicolide
As shown in Table 13, fluorine thiazole pyrrole ethyl ketone and fluopicolide proportioning are all greater than 1.5 when 1 ︰ 80 ~ 80 ︰ 1 to the synergy ratio SR of cucumber downy mildew, both explanations mixture in 1 ︰ 80 ~ 80 ︰ 1 scope all shows synergistic effect, when the proportioning of fluorine thiazole pyrrole ethyl ketone and fluopicolide is at 20:1 ~ 1:20, synergistic effect is more outstanding, synergy ratio is all more than 2.30, when the proportioning of fluorine thiazole pyrrole ethyl ketone and fluopicolide is at 9:1 ~ 1:9, synergistic effect is the most outstanding, and synergy ratio is all more than 2.45.Testing through applicant the optimum ratio finding fluorine thiazole pyrrole ethyl ketone and fluopicolide is 20 ︰ 1, 19 ︰ 1, 18 ︰ 1, 17 ︰ 1, 16 ︰ 1, 15 ︰ 1, 14 ︰ 1, 13 ︰ 1, 12 ︰ 1, 11 ︰ 1, 10 ︰ 1, 9 ︰ 1, 8 ︰ 1, 7 ︰ 1, 6 ︰ 1, 5 ︰ 1, 4 ︰ 1, 3 ︰ 1, 2 ︰ 1, 1 ︰ 1, 1 ︰ 2, 1 ︰ 3, 1 ︰ 4, 1 ︰ 5, 1 ︰ 6, 1 ︰ 7, 1 ︰ 8, 1 ︰ 9, 1 ︰ 10, 1 ︰ 11, 1 ︰ 12, 1 ︰ 13, 1 ︰ 14, 1 ︰ 15, 1 ︰ 16, 1 ︰ 17, 1 ︰ 18, 1 ︰ 19, during 1 ︰ 20, especially when fluorine thiazole pyrrole ethyl ketone and fluopicolide weight ratio are 2:3, synergy ratio is maximum, synergistic effect is the most obvious.
Application Example seven
For examination disease: cucumber downy mildew
Test medicine provides by Shaanxi Meibang Pesticide Co., Ltd..
Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination fluorine thiazole pyrrole ethyl ketone and the former medicine of Guardian and the two different ratio mixture.
Table 14 fluorine thiazole pyrrole ethyl ketone and the composite toxicity test analysis of results table to cucumber downy mildew of Guardian
As shown in Table 14, fluorine thiazole pyrrole ethyl ketone and Guardian proportioning are all greater than 1.5 when 1 ︰ 80 ~ 80 ︰ 1 to the synergy ratio SR of cucumber downy mildew, both explanations mixture in 1 ︰ 80 ~ 80 ︰ 1 scope all shows synergistic effect, when the proportioning of fluorine thiazole pyrrole ethyl ketone and Guardian is at 20:1 ~ 1:20, synergistic effect is more outstanding, synergy ratio is all more than 2.25, when the proportioning of fluorine thiazole pyrrole ethyl ketone and Guardian is at 9:1 ~ 1:9, synergistic effect is the most outstanding, and synergy ratio is all more than 2.40.Testing through applicant the optimum ratio finding fluorine thiazole pyrrole ethyl ketone and Guardian is 20 ︰ 1, 19 ︰ 1, 18 ︰ 1, 17 ︰ 1, 16 ︰ 1, 15 ︰ 1, 14 ︰ 1, 13 ︰ 1, 12 ︰ 1, 11 ︰ 1, 10 ︰ 1, 9 ︰ 1, 8 ︰ 1, 7 ︰ 1, 6 ︰ 1, 5 ︰ 1, 4 ︰ 1, 3 ︰ 1, 2 ︰ 1, 1 ︰ 1, 1 ︰ 2, 1 ︰ 3, 1 ︰ 4, 1 ︰ 5, 1 ︰ 6, 1 ︰ 7, 1 ︰ 8, 1 ︰ 9, 1 ︰ 10, 1 ︰ 11, 1 ︰ 12, 1 ︰ 13, 1 ︰ 14, 1 ︰ 15, 1 ︰ 16, 1 ︰ 17, 1 ︰ 18, 1 ︰ 19, during 1 ︰ 20, especially when fluorine thiazole pyrrole ethyl ketone and Guardian weight ratio are 1:1, synergy ratio is maximum, synergistic effect is the most obvious.
Through test find: fluorine thiazole pyrrole ethyl ketone and active component B composite after have obvious synergistic effect to the control of the gray mold in various crop, epidemic disease, spot defoliation, brown spot, zonate spot, crown rot, spike rot, stalk break, powdery mildew, rust, head mold disease, club root, rice blast, damping off or downy mildew, synergy ratio SR is all greater than 1.5.
Effect experiment part: test medicine is researched and developed by Shaanxi Meibang Pesticide Co., Ltd., provided, contrast medicament: 20% fluorine thiazole pyrrole ethyl ketone oil-suspending agent (autogamy), 50% iprodione wettable powder (commercial), 24% Acibenzolar suspending agent (autogamy), 500g/ fluazinam suspending agent (autogamy), 5% pyridine bacterium amine suspending agent (autogamy), 25% fluopicolide suspending agent (autogamy), 20% Guardian wetting powder (commercial).
Application Example octafluoro thiazole pyrrole ethyl ketone and active component B and the composite control cucumber downy mildew test of pesticide effectiveness thereof
This test arrangement is at Xian District, Shanxi Province suburban area, and investigation cucumber downy mildew disease index before medicine, in the dispenser of disease initial stage of origination, 3 days, 10 days, 20 days investigation disease indexes after dispenser also calculate preventive effect.Result of the test is as follows:
Table 15 fluorine thiazole pyrrole ethyl ketone and active component B and the composite control cucumber downy mildew test of pesticide effectiveness thereof
As can be seen from Table 15, fluorine thiazole pyrrole ethyl ketone and active component B composite after effectively can prevent and treat cucumber downy mildew, through applicant test find fluorine thiazole pyrrole ethyl ketone and active component B composite after also can effectively prevent and treat powdery mildew of cucumber, gray mold of cucumber, control efficiency is all higher than 97%, be better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example nine fluorine thiazole pyrrole ethyl ketone and active component B and the composite control graw mold of tomato test of pesticide effectiveness thereof
This test arrangement is at Xianyang, Shanxi province suburban area, and investigation graw mold of tomato disease index before medicine, in the dispenser of disease initial stage of origination, 3 days, 10 days, 20 days investigation disease indexes after dispenser also calculate preventive effect.Result of the test is as follows:
Table 16 fluorine thiazole pyrrole ethyl ketone and active component B and the composite control graw mold of tomato test of pesticide effectiveness thereof
As can be seen from Table 16, fluorine thiazole pyrrole ethyl ketone and active component B composite after effectively can prevent and treat graw mold of tomato, through applicant test find fluorine thiazole pyrrole ethyl ketone and active component B composite after also effectively can prevent and treat tomato blight, tomato powdery mildew, control efficiency is all higher than 97%, be better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example ten fluorine thiazole pyrrole ethyl ketone and active component B and the composite control capsicum epidemic disease test of pesticide effectiveness thereof
This test arrangement is in Weinan City suburb, Shaanxi Province, and investigation capsicum epidemic disease disease index before medicine, in the dispenser of disease initial stage of origination, 3 days, 10 days, 20 days investigation disease indexes after dispenser also calculate preventive effect.Result of the test is as follows:
Table 17 fluorine thiazole pyrrole ethyl ketone and active component B and the composite control capsicum epidemic disease test of pesticide effectiveness thereof
As can be seen from Table 17, fluorine thiazole pyrrole ethyl ketone and active component B composite after effectively can prevent and treat capsicum epidemic disease, through applicant test find fluorine thiazole pyrrole ethyl ketone and active component B composite after also effectively can prevent and treat tomato blight, tomato powdery mildew, control efficiency is all higher than 97%, be better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example 11 fluorine thiazole pyrrole ethyl ketone and active component B and the composite control rice blast test of pesticide effectiveness thereof
This test arrangement is at Shaanxi Province's Hanzhong City, and investigation rice blast disease index before medicine, in the dispenser of disease initial stage of origination, 3 days, 10 days, 20 days investigation disease indexes after dispenser also calculate preventive effect.Result of the test is as follows:
Table 18 fluorine thiazole pyrrole ethyl ketone and active component B and the composite control rice blast test of pesticide effectiveness thereof
As can be seen from Table 18, fluorine thiazole pyrrole ethyl ketone and active component B composite after effectively can prevent and treat rice blast, control efficiency, all higher than 97%, is better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example ten difluoro thiazole pyrrole ethyl ketone and active component B and the composite control wheat powdery mildew test of pesticide effectiveness thereof
This test arrangement is at Xian District, Shanxi Province suburban area, and investigation wheat powdery mildew disease index before medicine, in the dispenser of disease initial stage of origination, 3 days, 10 days, 20 days investigation disease indexes after dispenser also calculate preventive effect.Result of the test is as follows:
Table 19 fluorine thiazole pyrrole ethyl ketone and active component B and the composite control wheat powdery mildew test of pesticide effectiveness thereof
As can be seen from Table 19, fluorine thiazole pyrrole ethyl ketone and active component B composite after effectively can prevent and treat wheat powdery mildew, through applicant test find fluorine thiazole pyrrole ethyl ketone and active component B composite after also effectively can prevent and treat wheat rust, control efficiency is all higher than 97%, be better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
After draw through tests different local throughout the country, fluorine thiazole pyrrole ethyl ketone and the composite rear preventive effect to Common Diseases such as the gray mold in various crop, epidemic disease, spot defoliation, brown spot, zonate spot, crown rot, spike rot, stalk break, powdery mildew, rust, head mold disease, club root, rice blast, damping off or downy mildew of iprodione, Acibenzolar, fluazinam, pyridine bacterium amine, fluopicolide or Guardian are all more than 97%, be better than single dose preventive effect, synergistic effect is obvious.
Claims (6)
1. the bactericidal composition of a fluorine-containing thiazole pyrrole ethyl ketone, effective active composition is active components A and active component B, it is characterized in that: active components A and active component B weight ratio are 1 ︰ 80 ~ 80 ︰ 1, described active components A is selected from fluorine thiazole pyrrole ethyl ketone, and active component B is selected from the one in iprodione, Acibenzolar, fluazinam, pyridine bacterium amine, fluopicolide or Guardian.
2. the bactericidal composition of fluorine-containing thiazole pyrrole ethyl ketone according to claim 1, is characterized in that: the weight ratio of active components A and active component B is 1 ︰ 50 ~ 50 ︰ 1.
3. the bactericidal composition of fluorine-containing thiazole pyrrole ethyl ketone according to claim 2, is characterized in that:
The weight ratio of fluorine thiazole pyrrole ethyl ketone and iprodione is 15:1 ~ 1:25;
The weight ratio of fluorine thiazole pyrrole ethyl ketone and Acibenzolar is 30:1 ~ 1:10;
The weight ratio of fluorine thiazole pyrrole ethyl ketone and fluazinam is 20:1 ~ 1:20;
The weight ratio of fluorine thiazole pyrrole ethyl ketone and pyridine bacterium amine is 25:1 ~ 1:15;
The weight ratio of fluorine thiazole pyrrole ethyl ketone and fluopicolide is 20:1 ~ 1:20;
The weight ratio of fluorine thiazole pyrrole ethyl ketone and Guardian is 20:1 ~ 1:20.
4. the bactericidal composition of fluorine-containing thiazole pyrrole ethyl ketone according to any one of claim 1 to 3, is characterized in that: composition makes wetting powder, water dispersible granules, suspending agent, oil-suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent or microcapsule suspension-suspendinagent agent.
5. the bactericidal composition of fluorine-containing thiazole pyrrole ethyl ketone according to claim 4 is for preventing and treating the purposes of disease on crops.
6. purposes according to claim 5, it is characterized in that, described disease is: gray mold, epidemic disease, spot defoliation, brown spot, zonate spot, crown rot, spike rot, stalk break, powdery mildew, rust, head mold disease, club root, rice blast, damping off or downy mildew.
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| CN105052945A (en) * | 2015-09-09 | 2015-11-18 | 江苏省绿盾植保农药实验有限公司 | Fungicide composition containing fluopicolide and oxathiapiprolin |
| CN105941426A (en) * | 2016-07-25 | 2016-09-21 | 李祥英 | Pesticide composition containing oxathiapiprolin and copper succinate |
| WO2016173996A1 (en) * | 2015-04-29 | 2016-11-03 | Bayer Cropscience Aktiengesellschaft | Use of 2-{3-[2-(1-{[3,5-bis(difluoromethyl)-1h-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}-3-chlorophenyl methanesulfonate |
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| WO2017094576A1 (en) * | 2015-12-01 | 2017-06-08 | 住友化学株式会社 | Plant disease control composition, and plant disease control method |
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| CN101969781A (en) * | 2007-10-23 | 2011-02-09 | 杜邦公司 | Fungicidal compounds and mixtures |
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| WO2016173996A1 (en) * | 2015-04-29 | 2016-11-03 | Bayer Cropscience Aktiengesellschaft | Use of 2-{3-[2-(1-{[3,5-bis(difluoromethyl)-1h-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}-3-chlorophenyl methanesulfonate |
| CN105052945A (en) * | 2015-09-09 | 2015-11-18 | 江苏省绿盾植保农药实验有限公司 | Fungicide composition containing fluopicolide and oxathiapiprolin |
| WO2017094576A1 (en) * | 2015-12-01 | 2017-06-08 | 住友化学株式会社 | Plant disease control composition, and plant disease control method |
| CN108289446A (en) * | 2015-12-01 | 2018-07-17 | 住友化学株式会社 | Control of plant disease composition and control of plant disease method |
| US10631540B2 (en) | 2015-12-01 | 2020-04-28 | Sumitomo Chemical Company, Limited | Plant disease control composition, and plant disease control method |
| AU2016364422B2 (en) * | 2015-12-01 | 2021-04-15 | Sumitomo Chemical Company, Limited | Plant disease control composition, and plant disease control method |
| CN105941426A (en) * | 2016-07-25 | 2016-09-21 | 李祥英 | Pesticide composition containing oxathiapiprolin and copper succinate |
| CN106172433A (en) * | 2016-07-25 | 2016-12-07 | 李祥英 | A kind of fluorine-containing thiazole pyrrole ethyl ketone and the composition pesticide of amino-oligosaccharide |
| CN106212476A (en) * | 2016-08-03 | 2016-12-14 | 田文华 | A kind of fluorine-containing thiazole pyrrole ethyl ketone and the bactericidal composition of copper rosinate |
| CN106234377A (en) * | 2016-08-03 | 2016-12-21 | 李祥英 | A kind of fluorine-containing thiazole pyrrole ethyl ketone and the complex composition of acetaminol |
| CN106234389A (en) * | 2016-08-03 | 2016-12-21 | 李祥英 | A kind of fluorine-containing thiazole pyrrole ethyl ketone and the composition pesticide of berberine |
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