CN101642129A - Sterilization composite - Google Patents
Sterilization composite Download PDFInfo
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- CN101642129A CN101642129A CN200910150371A CN200910150371A CN101642129A CN 101642129 A CN101642129 A CN 101642129A CN 200910150371 A CN200910150371 A CN 200910150371A CN 200910150371 A CN200910150371 A CN 200910150371A CN 101642129 A CN101642129 A CN 101642129A
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Abstract
The invention discloses a sterilization composite. The active components thereof is cyprodinil (A) and triazole fungicide (B), B is difenoconazole, hexaconazole, propiconazole, flusilazole, penconazole, triazolone, diniconazole, triflumizole or flutriafol; the mass ratio of (A) and (B) is 50-1:1-50. The active components (A) and (B) have obvious synergized effect after compounding in curing and preventing diseases, especially fungal diseases, of crops of fruit tree, cotton, rice, vegetable and the like.
Description
Technical field
The present invention relates to a kind of bactericidal composition, especially a kind of bactericidal composition that contains cyprodinil.
Background technology
In recent years, because single drug and the medication of non-science have caused many diseases that the agricultural chemicals of current use has been produced resistance,, become a great problem of chemical control as rice blast, gray mold, powdery mildew, scab, the rot etc. that is full of.Simultaneously, frequent dispenser causes peasant burden to increase the weight of and increasing environmental pollution again.Therefore, be badly in need of the bactericide new varieties of efficient, low toxicity, environmental protection.
Cyprodinil, English common name Cyprodinil, chemical name 4-cyclopropyl-6-methyl-N-phenyl pyrimidine-2-amine; it is a kind of protective fungicide; the mechanism of action is the methionine biosynthesis inhibitor, works after spore germination, suppresses the process that penetrates and the mycelial growth of fungi.There is not cross resistance with bactericide such as triazole type, imidazoles, morpholine class, phenylpyrrole classes.Be mainly used in and prevent and treat gray mold, powdery mildew, scab, glume blight and wheat eyeprint disease etc.But use relative price higher separately, and the disease species that can prevent and treat is insufficient.
The triazole bactericidal agent bactericidal mechanism is complicated, mainly is the biosynthesis that suppresses the thalline ergosterol, thereby inhibition or interference thalline adhere to the growth of spore and haustorium, the growth of mycelia and the formation of spore.Better to the powdery mildew effect, but the white powder germ in many areas has resistance to triazole type, single undesirable with effect.In addition, most triazole bactericidal agents in use cause poisoning to crop easily.
In view of this, necessary safety, the efficient bactericidal composite that uses on a kind of suitable agricultural that provide.
Summary of the invention
The objective of the invention is to: the safe and efficient bactericidal composition that uses on a kind of suitable agricultural, disease had outstanding control efficiency is provided.
For solving the problems of the technologies described above, the inventor is by a large amount of biologicall test screenings, and unexpected discovery cyprodinil and triazole bactericidal agent are composite with certain proportion, and diseases such as rice blast, powdery mildew, gray mold are had significant synergies.
On the basis of above-mentioned discovery, through composition is carried out symphyogenetic quantitative analysis, formed technical scheme of the present invention, promptly with cyprodinil (A) be a kind of active ingredient, with a kind of triazole bactericidal agent (B) for another active ingredient, be 50 (A): 1-1: 50 with (B) mass ratio; Described triazole bactericidal agent is Difenoconazole, own azoles alcohol, propiconazole, Flusilazole, penconazole, triazolone, alkene azoles alcohol, fluorine bacterium azoles or Flutriafol.
As a kind of improvement of the present invention, active ingredient (A) with (B) preferably ratio be 20: 1-1: 20.
The present composition can be prepared into known method and be fit to the formulation that agricultural is used, and the total content of active ingredient is 5%-80% in the preparation.
The adjuvant that uses in the composition of the present invention comprises that dispersant, wetting agent, antifreezing agent, bleeding agent etc. and other are of value to the known substance that active ingredient is stablized and drug effect is brought into play in storing and using, all be the various compositions of using or allow use in the pesticidal preparations always, be not particularly limited, concrete composition and consumption require to determine by simple experiment according to prescription.
Composition described in the invention can the finished product preparation form provide, and promptly each material mixes in the composition, and the composition of composition also can provide with single agent form, directly directly mixes in bucket or jar before the use, is diluted to required concentration then.
Bactericidal composition of the present invention is mainly used in the disease of crops such as fruit tree, cotton, paddy rice, vegetables, especially fungal disease control.
Compared with prior art, the beneficial effect of the present invention's generation is: (1) is compared with single agent, and this bactericidal composition has tangible synergy to diseases such as rice blast, powdery mildew, gray molds, has improved control efficiency; And, because reduced the consumption of triazole bactericidal agent, to the safety raising of crop.(2) can significantly reduce the field dosage, effectively reduce environmental pollution and residue of pesticide, reduce and produce and use cost; (3) mechanism of action of active ingredient is different in the bactericidal composition, helps overcoming and delaying the generation of disease drug resistance.
Embodiment
In order to make purpose of the present invention, technical scheme and advantage clearer, the present invention describes with following specific embodiment, but the present invention is limited to these examples absolutely not.
The combination of active principles of different agricultural chemicals being carried out composite, is a kind of mode effectively and efficiently that solves some problems in the agricultural chemicals list agent application process at present.The agricultural chemicals of different cultivars shows three kinds of type of action after mixing usually, and promptly summation action, synergistic effect and antagonism act on but which kind of is specially, and be unpredictable, has only by a large amount of tests and just can know.Compound synergic is well filled a prescription, and can improve actual control efficiency, reduces the usage amount of agricultural chemicals, helps the generation of delaying drug resistance, is the important means of integrated control.
The present composition is that a kind of active ingredient, a kind of triazole bactericidal agent (B) are another active ingredient with cyprodinil (A), combination has obvious role in synergism to diseases such as rice blast, powdery mildew, gray molds between them, and be not only the simple addition of two kinds of medicament effects, this can very clearly from the result of following biologicall test example find out.
Biologicall test example 1 cyprodinil (A) and the composite toxicity test of a kind of triazole bactericidal agent (B) to powdery mildew of cucumber
Subjects: powdery mildew of cucumber
Test is with reference to " pesticide bioassay technology " (old spring chief editor, publishing house of Beijing Agricultural University publishes), and the potted plant determination method of powdery mildew of cucumber is adopted in " agricultural chemicals indoor bioassay test rule NY/T1156.2-2006 " this test.On the basis of preliminary experiment, select 2 leaf periods, the consistent melon seedling of growing way, write tag number, insert in the potted plant cucumber seedling basin with permanent pen, discharging according to the order of sequence, adopt the foliar spray method, medicament is sprayed on the melon seedling leaf, will tries material after spraying is handled and in fume hood or greenhouse, dry in the shade and inoculate behind the 24h.Cultivate 7d investigation prevention effect in the greenhouse, grade scale is carried out State Standard of the People's Republic of China " pesticide field efficacy medicine test criterion () ", calculates control efficiency with disease index, carries out statistical analysis with the DPS data processing software, calculates the EC of each medicament
50, press the abundant method of Sun Yun then and calculate co-toxicity coefficient (CTC).
When CTC≤80, then the composition performance is for antagonism, and when 80＜CTC＜120, then the composition performance is for summation action, and when CTC 〉=120, then the composition performance is synergistic effect.
Actual measurement toxicity index (ATI)=(standard medicament EC
50/ reagent agent EC
50) * 100
The percentage composition of B in percentage composition+B medicament toxicity index * mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixture
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (the ATI)/theoretical toxicity index (TTI) of mixture] * 100
The composite measurement result of cyprodinil and Difenoconazole sees Table 1, and the composite measurement result of cyprodinil and Flutriafol sees Table 2.
The serial proportioning of table 1 composition is to the Toxicity Determination result of powdery mildew of cucumber
| Handle | ??EC 50(μ ??g/mL) | ??ATI | ??TTI | Co-toxicity coefficient CTC |
| Cyprodinil | ??8.12 | ??100 | ??/ | ??/ |
| Difenoconazole | ??15.02 | ??54.1 | ??/ | ??/ |
| Cyprodinil 50: Difenoconazole 1 | ??5.07 | ??160.2 | ??99.1 | ??161.6 |
| Cyprodinil 20: Difenoconazole 1 | ??4.62 | ??175.8 | ??97.8 | ??179.7 |
| Cyprodinil 10: Difenoconazole 1 | ??3.85 | ??210.9 | ??95.8 | ??220.1 |
| Cyprodinil 5: Difenoconazole 1 | ??2.22 | ??365.8 | ??92.3 | ??396.1 |
| Cyprodinil 1: Difenoconazole 1 | ??2.57 | ??316.0 | ??77.0 | ??410.2 |
| Cyprodinil 1: Difenoconazole 5 | ??3.28 | ??247.6 | ??61.7 | ??401.1 |
| Cyprodinil 1: Difenoconazole 20 | ??5.94 | ??136.7 | ??56.2 | ??243.0 |
| Cyprodinil 1: Difenoconazole 50 | ??8.72 | ??93.1 | ??55.0 | ??169.4 |
Result of the test shows, the composite powdery mildew of cucumber of preventing and treating of cyprodinil and Difenoconazole, proportioning is 50: 1-1: in the time of between 50, co-toxicity coefficient CTC is more than 120, has obvious synergistic effect, and 20: 1-1: in the time of between 20, listed proportioning co-toxicity coefficient all is higher than 179.7, and synergistic effect is more obvious.
The serial proportioning of table 2 composition is to the Toxicity Determination result of powdery mildew of cucumber
| Handle | ??EC 50(μ ??g/mL) | ??ATI | ??TTI | Co-toxicity coefficient CTC |
| Cyprodinil | ??14.12 | ??100 | ??/ | ??/ |
| Flutriafol | ??20.15 | ??70.1 | ??/ | ??/ |
| Cyprodinil 50: Flutriafol 1 | ??10.13 | ??139.4 | ??99.4 | ??140.2 |
| Cyprodinil 20: Flutriafol 1 | ??9.72 | ??145.3 | ??98.6 | ??147.4 |
| Cyprodinil 10: Flutriafol 1 | ??9.52 | ??148.3 | ??97.3 | ??152.5 |
| Cyprodinil 5: Flutriafol 1 | ??9.35 | ??151.0 | ??95.0 | ??158.9 |
| Cyprodinil 1: Flutriafol 1 | ??8.73 | ??161.7 | ??85.0 | ??190.2 |
| Cyprodinil 1: Flutriafol 5 | ??12.74 | ??110.8 | ??75.1 | ??147.7 |
| Cyprodinil 1: Flutriafol 20 | ??13.54 | ??104.3 | ??71.5 | ??145.9 |
| Cyprodinil 1: Flutriafol 50 | ??15.12 | ??93.4 | ??70.7 | ??132.2 |
Result of the test shows, the composite powdery mildew of cucumber of preventing and treating of cyprodinil and Flutriafol, and proportioning is 50: 1-1: in the time of between 50, co-toxicity coefficient CTC all is higher than 120, the tool synergistic effect, and 20: 1-1: in the time of between 20, listed proportioning co-toxicity coefficient is all more than 145.9, and synergistic effect is more obvious.
Biologicall test example 2: cyprodinil (A) and the composite toxicity test of a kind of triazole bactericidal agent (B) to rice blast
Subjects: rice blast fungus
Test is with reference to " pesticide bioassay technology " (old spring chief editor, publishing house of Beijing Agricultural University publishes), and live body pot experiment method is adopted in " agricultural chemicals indoor bioassay test rule NY/T1156.2-2006 " this test, every basin rice cultivation 2 strains, five repetitions of each concentration, each is handled and amounts to 10 strain paddy rice, divides and makes 5 basins.Make blank with the clear water processing.With cultured pathogen, wash surperficial spore with sterile water, be made into 1 * 10
6Individual spore/ml spore suspension, paddy rice are seeded in evenly sprinkling inoculation on the rice leaf with the crop sprayer during tri-leaf period.Behind the dark 24h, preserve moisture, take out behind the 10d.Add up the scab number on every strain rice leaf (amounting to 30 leaves), carry out classification according to the leaf spot lesion number.Calculate control efficiency with disease index, carry out statistical analysis, calculate the EC of each medicament with the DPS data processing software
50, press the abundant method of Sun Yun then and calculate co-toxicity coefficient (CTC).
Grade scale:
Leaf pest (is unit with the blade)
0 grade: anosis;
1 grade: leaf spot lesion is less than 5, and length is less than 1cm;
3 grades: leaf spot lesion 6-10, part scab length is greater than 1cm;
5 grades: leaf spot lesion 11-25, the part scab is linked to be sheet, accounts for leaf area 10%-25%;
7 grades: leaf spot lesion is more than 26, and scab is linked to be sheet, accounts for leaf area 26-50%;
9 grades: scab is linked to be sheet, and leaf is withered more than 50% or entirely to account for leaf area.
The drug effect computational methods:
Cyprodinil respectively with own azoles alcohol, propiconazole compound to the measurement result of rice blast see Table 3, table 4.
The serial proportioning of table 3 composition is to the Toxicity Determination result of rice blast
| Handle | ??EC 50(μ ??g/mL) | ??ATI | ??TTI | Co-toxicity coefficient CTC |
| Cyprodinil | ??9.12 | ??100 | ??/ | ??/ |
| Own azoles alcohol | ??15.02 | ??60.7 | ??/ | ??/ |
| Cyprodinil 50: own azoles alcohol 1 | ??7.07 | ??129.0 | ??99.2 | ??130.0 |
| Cyprodinil 20: own azoles alcohol 1 | ??6.12 | ??149.0 | ??98.1 | ??151.9 |
| Cyprodinil 10: own azoles alcohol 1 | ??5.85 | ??155.9 | ??96.4 | ??161.7 |
| Cyprodinil 5: own azoles alcohol 1 | ??5.67 | ??160.8 | ??93.5 | ??172.1 |
| Cyprodinil 1: own azoles alcohol 1 | ??7.37 | ??123.7 | ??80.4 | ??154.0 |
| Cyprodinil 1: own azoles alcohol 5 | ??8.08 | ??112.9 | ??67.3 | ??167.8 |
| Cyprodinil 1: own azoles alcohol 20 | ??8.94 | ??102.0 | ??62.6 | ??163.0 |
| Cyprodinil 1: own azoles alcohol 50 | ??10.42 | ??87.5 | ??61.5 | ??142.3 |
Result of the test shows, cyprodinil and the composite control rice blast of own azoles alcohol, proportioning is 50: 1-1: in the time of between 50, co-toxicity coefficient CTC is more than 130.0, has obvious synergistic effect, and 20: 1-1: in the time of between 20, listed proportioning co-toxicity coefficient all is higher than 151.9, and synergistic effect is the most obvious.
The serial proportioning of table 4 composition is to the Toxicity Determination result of rice blast
| Handle | ??EC 50(μ ??g/mL) | ??ATI | ??TTI | Co-toxicity coefficient CTC |
| Cyprodinil | ??7.12 | ??100 | ??/ | ??/ |
| Propiconazole | ??13.25 | ??53.7 | ??/ | ??/ |
| Cyprodinil 50: propiconazole 1 | ??4.87 | ??146.2 | ??99.1 | ??147.5 |
| Cyprodinil 20: propiconazole 1 | ??4.22 | ??168.7 | ??97.8 | ??172.5 |
| Cyprodinil 10: propiconazole 1 | ??4.22 | ??168.7 | ??95.8 | ??176.1 |
| Cyprodinil 5: propiconazole 1 | ??3.87 | ??184.0 | ??92.3 | ??199.4 |
| Cyprodinil 1: propiconazole 1 | ??3.42 | ??208.2 | ??76.9 | ??270.8 |
| Cyprodinil 1: propiconazole 5 | ??4.79 | ??148.6 | ??61.4 | ??241.9 |
| Cyprodinil 1: propiconazole 20 | ??4.57 | ??155.8 | ??55.9 | ??278.5 |
| Cyprodinil 1: propiconazole 50 | ??7.92 | ??89.9 | ??54.6 | ??164.5 |
Result of the test shows, cyprodinil and propiconazole compound control rice blast, proportioning is 50: 1-1: in the time of between 50, co-toxicity coefficient CTC all is higher than 147.5, has obvious synergistic effect, and 20: 1-1: in the time of between 20, listed proportioning co-toxicity coefficient is all more than 172.5, and synergistic effect is the most obvious.
Biologicall test example 3: cyprodinil (A) and the composite toxicity test of a kind of triazole bactericidal agent (B) to gray mold
Subjects: gray mold of cucumber germ, graw mold of tomato germ
Test is adopted growth rate method (Plating) with reference to " pesticide bioassay technology " (old spring chief editor, publishing house of Beijing Agricultural University publishes) and " agricultural chemicals indoor bioassay test rule NY/T1156.2-2006 ".On the basis of preliminary experiment, on the sterile working platform, handling the sterilising medium that will melt in advance according to test quantitatively places in the aseptic conical flask, getting the 5ml soup from the low concentration to the high concentration successively joins respectively the hot medium of 45ml (PDA medium is housed, 45-50 ℃) conical flask in, after shaking up, pour diameter 90mm glass culture dish rapidly into, each culture dish is poured band medicine medium 10ml into.Level leaves standstill, and makes flat board after the cooling.Five repetitions of each concentration.Make blank with the processing that does not contain the medicament effective ingredient.With cultured pathogen, under aseptic condition,, cut the bacterium cake from colony edge with the sterilization card punch of diameter 4mm, with inoculator the bacterium cake is inoculated in the dull and stereotyped central authorities of pastille, will there be one of mycelia to face down and the medium applying, cover the ware lid.Above all operations all carries out sterile working at superclean bench.Be placed on after the processing in 26 ± 0.5 ℃ the constant temperature aseptic culture case and cultivate, take out behind the 5d.Adopt the right-angled intersection method to measure the colony diameter (is unit with the millimeter) that each is handled respectively, calculate the mean value of colony diameter.Carry out statistical analysis with the DPS data processing software, calculate the EC of each medicament
50, press the abundant method of Sun Yun then and calculate co-toxicity coefficient (CTC).
The composite measurement result to botrytis cinerea pers of cyprodinil and penconazole sees Table 5, and the composite measurement result to botrytis cinerea pers of cyprodinil and Flusilazole sees Table 6.
The serial proportioning of table 5 composition is to the Toxicity Determination result of gray mold of cucumber
Result of the test shows, the composite control gray mold of cucumber of cyprodinil and penconazole, proportioning is 50: 1-1: in the time of between 50, listed proportioning co-toxicity coefficient CTC is more than 146.6, has obvious synergistic effect, and 20: 1-1: in the time of between 20, listed proportioning co-toxicity coefficient all is higher than 219.4, and synergistic effect is the most obvious.
The serial proportioning of table 6 composition is to the Toxicity Determination result of graw mold of tomato
| Handle | ??EC 50(μ ??g/mL) | ??ATI | ??TTI | Co-toxicity coefficient CTC |
| Cyprodinil | ??0.82 | ??100 | ??/ | ??/ |
| Flusilazole | ??1.22 | ??67.2 | ??/ | ??/ |
| Cyprodinil 50: Flusilazole 1 | ??0.58 | ??141.4 | ??99.4 | ??142.3 |
| Cyprodinil 20: Flusilazole 1 | ??0.53 | ??154.7 | ??98.4 | ??157.2 |
| Cyprodinil 10: Flusilazole 1 | ??0.51 | ??160.8 | ??97.0 | ??165.7 |
| Cyprodinil 5: Flusilazole 1 | ??0.49 | ??167.3 | ??94.5 | ??177.0 |
| Cyprodinil 1: Flusilazole 1 | ??0.47 | ??174.5 | ??83.6 | ??208.7 |
| Cyprodinil 1: Flusilazole 5 | ??0.58 | ??141.4 | ??72.7 | ??194.5 |
| Cyprodinil 1: Flusilazole 20 | ??0.64 | ??128.1 | ??68.8 | ??186.3 |
| Cyprodinil 1: Flusilazole 50 | ??0.82 | ??100.0 | ??67.9 | ??147.4 |
Result of the test shows, the composite control graw mold of tomato of cyprodinil and Flusilazole, proportioning is 50: 1-1: in the time of between 50, listed proportioning co-toxicity coefficient CTC all is higher than 142.3, has obvious synergistic effect, and 20: 1-1: in the time of between 20, listed proportioning co-toxicity coefficient is all more than 157.2, and synergistic effect is the most obvious.
By the mensuration on multiple object, the result shows that all cyprodinil (A) and a kind of triazole bactericidal agent (B) of selecting are composite at proportioning 50: 1-1: in the time of between 50, has synergistic effect, 20: 1-1: in the time of between 20, synergistic effect is more obvious, and co-toxicity coefficient is more than 145.9.
Bactericidal composition of the present invention can be prepared into known method and be fit to wetting powder, suspending agent, missible oil, aqueous emulsion, microemulsion or the water dispersible granules that agricultural is used.Below describe with specific embodiment, percentage is mass percent in the prescription.
The agent of embodiment 1:51% cyprodinil difenoconazole suspending
Cyprodinil 50%
Difenoconazole 1%
Methyl naphthalene sulfonate formaldehyde condensate (dispersant) 10%
Xanthans (thickener) 1%
Bentonite (carrier) 1%
Glycerine (antifreeze) 1%
Water complements to 100%.
With active component (present specification middle finger cyprodinil and triazole bactericidal agent, below repeat no more) each component such as former medicine, dispersant, wetting agent and water mix in the ratio of prescription, through grind and/or high speed shear after obtain 51% cyprodinil difenoconazole suspending agent.
This embodiment is applied to prevent and treat powdery mildew of cucumber.51% cyprodinil difenoconazole suspending agent is sprayed by 2800 times of (cyprodinil valid density is 178.6g/ml, and Difenoconazole valid density is 3.6 μ g/ml) thin ups, and the control efficiency of 7 days and 15 days is respectively 96.5%, 94.2% behind the medicine.50% cyprodinil suspending agent by 2000 times (valid density is 250 μ g/ml) and 5% Difenoconazole missible oil by 1000 times (valid density is 50 μ g/ml), with using with quadrat method, the preventive effect of 7 days and 15 days is respectively 91.1%, 84.9% and 87.9%, 83.6% behind the medicine.The synergistic effect of the composite back of cyprodinil and Difenoconazole is obvious, to the preventive effect of powdery mildew of cucumber significantly better than single agent.
Embodiment 2:20% cyprodinil hexaconazole aqueous emulsion
Cyprodinil 15%
Own azoles alcohol 5%
N-Methyl pyrrolidone (solvent) 10%
Calcium dodecyl benzene sulfonate (emulsifier) 5%
The newborn 600# of farming (emulsifier) 5%
Water complements to 100%
Former medicine (present specification Central Plains medicine refers to active component chemosynthesis, unprocessed, below repeats no more), solvent, emulsifier are added together, make and be dissolved into even oil phase; With water-soluble component and the mixed water that gets of water; Under high-speed stirred, oil phase is mixed with water, make 20% cyprodinil hexaconazole aqueous emulsion.
This embodiment is applied to prevent and treat rice blast.By 1500 times of (cyprodinil valid density is 100 μ g/ml, and own azoles alcohol valid density is 33.3 μ g/ml) thin ups sprayings, the control efficiency of 7 days and 15 days is respectively 89.7%, 92.9% behind the medicine with 20% cyprodinil hexaconazole aqueous emulsion.20% cyprodinil suspending agent by 1500 times (valid density is 133.3 μ g/ml) and 10% hexaconazole suspending agent by 1000 times (valid density is 100 μ g/ml), with using with quadrat method, the preventive effect of 7 days and 15 days is respectively 86.3%, 87.2% and 82.8%, 83.4% behind the medicine.The composite back synergistic effect of cyprodinil and own azoles alcohol is obvious, to the preventive effect of rice blast significantly better than single agent.
Embodiment 3:5% cyprodinil penconazole microemulsion
Cyprodinil 2.5%
Penconazole 2.5%
N-Methyl pyrrolidone (solvent) 10%
Isopropyl alcohol (cosolvent) 15%
The newborn 500# of farming (emulsifier) 5%
The newborn 1601# of farming (emulsifier) 5%
Water complements to 100%.
Former medicine, solvent, emulsifier are added together, make and be dissolved into even oil phase; With water-soluble component and the mixed water that gets of water; Under high-speed stirred, oil phase is mixed with water, make 5% cyprodinil penconazole microemulsion.
This embodiment is applied to prevent and treat gray mold of cucumber.5% cyprodinil penconazole microemulsion is sprayed by 500 times of (cyprodinil valid density is 50 μ g/ml, and penconazole valid density is 50 μ g/ml) thin ups, and the control efficiency of 7 days and 15 days is respectively 85.2%, 82.3% behind the medicine.5% cyprodinil suspending agent by 500 times (valid density is 100 μ g/ml) and 5% penconazole suspending agent by 500 times (valid density is 100 μ g/ml), with using with quadrat method, the preventive effect of 7 days and 15 days is respectively 82.4%, 80.9% and 80.1%, 79.8% behind the medicine.The synergistic effect of the composite back of cyprodinil and penconazole is obvious, to the preventive effect of gray mold of cucumber significantly better than single agent.
Embodiment 4:31% cyprodinil Flusilazole wetting powder
Cyprodinil 1%
Flusilazole 30%
Lauryl sodium sulfate (wetting agent) 2%
Sodium lignin sulfonate (dispersant) 5%
Naphthalene sulfonate (dispersant) 3%
Kaolin (filler) complements to 100%.
Active component, various auxiliary agent and filler etc. are fully mixed in the ratio of prescription, after ultrafine crusher is pulverized, promptly get 31% cyprodinil Flusilazole wetting powder.
This embodiment is applied to pear scab.31% cyprodinil Flusilazole wetting powder is sprayed by 1500 times of (cyprodinil valid density is 6.7 μ g/ml, and Flusilazole valid density is 200 μ g/ml) thin ups, and the control efficiency of 7 days and 15 days is respectively 95.3%, 97.7% behind the medicine.5% cyprodinil suspending agent by 1000 times (valid density is 50 μ g/ml) and 30% Flusilazole missible oil by 1000 times (valid density is 300 μ g/ml), with using with quadrat method, the preventive effect of 7 days and 15 days is respectively 72.9%, 73.9% and 85.9%, 90.5% behind the medicine.The synergistic effect of the composite back of cyprodinil and Flusilazole is obvious, to the preventive effect of pear scab significantly better than single agent.
Embodiment 5:41% cyprodinil propiconazole emulsifiable concentrate
Cyprodinil 1%
Propiconazole 40%
N-Methyl pyrrolidone (solvent) 10%
DMF (solvent) 10%
The newborn 1601# of farming (emulsifier) 5%
The newborn 500# of farming (emulsifier) 5%
Dimethylbenzene (solvent) complements to 100%.
Active component, emulsifier and the auxiliary agent ratio in prescription is added in the mixing kettle successively, stir, make 41% cyprodinil propiconazole emulsifiable concentrate.
This embodiment apply to Section melon powdery mildew.41% cyprodinil propiconazole emulsifiable concentrate is sprayed by 3000 times of (cyprodinil valid density is 3.3 μ g/ml, and propiconazole valid density is 133.3 μ g/ml) thin ups, and the control efficiency of 7 days and 15 days is respectively 93.9%, 90.7% behind the medicine.5% cyprodinil suspending agent by 600 times (valid density is 83.3 μ g/ml) and 40% propiconazole emulsifiable concentrate by 2000 times (valid density is 200 μ g/ml), with using with quadrat method, the preventive effect of 7 days and 15 days is respectively 75.9%, 73.7% and 85.8%, 83.6% behind the medicine.Synergistic effect is obvious behind cyprodinil and the propiconazole compound, to the preventive effect of joint melon powdery mildew significantly better than single agent.
Embodiment 6:80% cyprodinil Flutriafol water dispersible granules
Cyprodinil 30%
Flutriafol 50%
Negel (dispersant) 4%
Sodium lignin sulfonate (dispersant) 2%
Lauryl sodium sulfate (wetting agent) 5%
Kaolin (filler) is to 100%
Active component, dispersant, wetting agent, disintegrant and the filler ratio in prescription is mixed, become wetting powder, add a certain amount of water mixing extruding again and make material through comminution by gas stream.Obtain 80% cyprodinil Flutriafol water dispersible granules after the drying screening.
This embodiment is applied to prevent and treat wheat powdery mildew.With 4000 times of 80% cyprodinil Flutriafol water dispersible granules (cyprodinil valid density is 75 μ g/ml, and Flutriafol valid density is 125 μ g/ml) thin up spraying, the control efficiency of 7 days and 15 days is respectively 97.9%, 94.7% behind the medicine.30% cyprodinil water dispersible granules by 2000 times (valid density is 150 μ g/ml) and 50% Flutriafol water dispersible granules by 2500 times (valid density is 200 μ g/ml), with using with quadrat method, the preventive effect of 7 days and 15 days is respectively 86.5%, 84.9% and 85.6%, 83.4% behind the medicine.The synergistic effect of the composite back of cyprodinil and Flutriafol is obvious, to the preventive effect of wheat powdery mildew significantly better than single agent.
Embodiment 7:30% cyprodinil difenoconazole water dispersible granule
Cyprodinil 25%
Difenoconazole 5%
Negel (dispersant) 4%
Sodium lignin sulfonate (dispersant) 2%
Lauryl sodium sulfate (wetting agent) 5%
Kaolin (filler) is to 100%
Active component, dispersant, wetting agent, disintegrant and the filler ratio in prescription is mixed, become wetting powder, add a certain amount of water mixing extruding again and make material through comminution by gas stream.Obtain 30% cyprodinil difenoconazole water dispersible granule after the drying screening.
This embodiment is applied to prevent and treat wheat powdery mildew.With 2000 times of 30% cyprodinil difenoconazole water dispersible granules (cyprodinil valid density is 125 μ g/ml, and Difenoconazole valid density is 25 μ g/ml) thin up spraying, the control efficiency of 7 days and 15 days is respectively 98.9%, 97.7% behind the medicine.30% cyprodinil water dispersible granules by 2000 times (valid density is 150 μ g/ml) and 10% difenoconazole water dispersible granule by 2000 times (valid density is 50 μ g/ml), with using with quadrat method, the preventive effect of 7 days and 15 days is respectively 89.5%, 87.9% and 82.6%, 80.4% behind the medicine.The synergistic effect of the composite back of cyprodinil and Difenoconazole is obvious, to the preventive effect of wheat powdery mildew significantly better than single agent.
Claims (8)
1, a kind of bactericidal composition, it is characterized in that: active ingredient is cyprodinil (A) and a kind of triazole bactericidal agent (B) in the described bactericidal composition, (B) being Difenoconazole, own azoles alcohol, propiconazole, Flusilazole, penconazole, triazolone, alkene azoles alcohol, fluorine bacterium azoles or Flutriafol, is 50 with (B) mass ratio (A): 1-1: 50.
2, according to claim 1, it is characterized in that: active ingredient (A) and mass ratio (B) are 20: 1-1: 20.
3, according to claim 1 or 2, it is characterized in that: also contain the pesticidal preparations auxiliary element in the described bactericidal composition, be fit to the formulation that agricultural is used so that make.
4, according to claim 3, it is characterized in that: the formulation that is fit to is wetting powder, missible oil, suspending agent, aqueous emulsion, microemulsion or water dispersible granules.
5, according to claim 3, it is characterized in that: active ingredient (A) is 5%-80% with (B) the gross mass percentage composition in bactericidal composition.
6, the described bactericidal composition of claim 1, the application on control of crop disease.
7, the application of bactericidal composition according to claim 6 is characterized in that: described crop is paddy rice, fruit tree, cotton, vegetables.
8, according to claim 6 or 7, it is characterized in that: described bactericidal composition be applied to prevent and treat fungal disease.
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| CN2009101503717A CN101642129B (en) | 2009-06-20 | 2009-06-20 | Sterilization composite |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102177895A (en) * | 2011-03-05 | 2011-09-14 | 陕西美邦农药有限公司 | Antibacterial composition containing cyprodinil |
| CN102696628A (en) * | 2012-07-10 | 2012-10-03 | 杭州宇龙化工有限公司 | Sterilization combination containing phenylate diazole and cyprodinil |
| CN102907437A (en) * | 2012-11-19 | 2013-02-06 | 江苏丰登农药有限公司 | Emulsifiable powder of preparation of Cyprodinil and triazole fungicide |
| CN103039461A (en) * | 2012-12-17 | 2013-04-17 | 广东中迅农科股份有限公司 | Pesticide composition containing zinc bacteria amine and hexaconazole |
| CN109699651A (en) * | 2019-01-27 | 2019-05-03 | 陕西上格之路生物科学有限公司 | A kind of bactericidal composition of the copper containing imidazole quinoline |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU652302B2 (en) * | 1991-12-19 | 1994-08-18 | Novartis Ag | Microbicides |
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2009
- 2009-06-20 CN CN2009101503717A patent/CN101642129B/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102177895A (en) * | 2011-03-05 | 2011-09-14 | 陕西美邦农药有限公司 | Antibacterial composition containing cyprodinil |
| CN102696628A (en) * | 2012-07-10 | 2012-10-03 | 杭州宇龙化工有限公司 | Sterilization combination containing phenylate diazole and cyprodinil |
| CN102907437A (en) * | 2012-11-19 | 2013-02-06 | 江苏丰登农药有限公司 | Emulsifiable powder of preparation of Cyprodinil and triazole fungicide |
| CN103039461A (en) * | 2012-12-17 | 2013-04-17 | 广东中迅农科股份有限公司 | Pesticide composition containing zinc bacteria amine and hexaconazole |
| CN109699651A (en) * | 2019-01-27 | 2019-05-03 | 陕西上格之路生物科学有限公司 | A kind of bactericidal composition of the copper containing imidazole quinoline |
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| CN101642129B (en) | 2012-06-27 |
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