CN101653140B - Compound bactericidal composition containing boscalid - Google Patents
Compound bactericidal composition containing boscalid Download PDFInfo
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- CN101653140B CN101653140B CN 200910161493 CN200910161493A CN101653140B CN 101653140 B CN101653140 B CN 101653140B CN 200910161493 CN200910161493 CN 200910161493 CN 200910161493 A CN200910161493 A CN 200910161493A CN 101653140 B CN101653140 B CN 101653140B
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- boscalid
- fludioxonil
- iprodione
- bactericidal composition
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- 239000005740 Boscalid Substances 0.000 title claims abstract description 84
- WYEMLYFITZORAB-UHFFFAOYSA-N boscalid Chemical compound C1=CC(Cl)=CC=C1C1=CC=CC=C1NC(=O)C1=CC=CN=C1Cl WYEMLYFITZORAB-UHFFFAOYSA-N 0.000 title claims abstract description 84
- 229940118790 boscalid Drugs 0.000 title claims abstract description 84
- 239000000203 mixture Substances 0.000 title claims abstract description 44
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 22
- 150000001875 compounds Chemical class 0.000 title description 2
- 239000005867 Iprodione Substances 0.000 claims abstract description 42
- ONUFESLQCSAYKA-UHFFFAOYSA-N iprodione Chemical compound O=C1N(C(=O)NC(C)C)CC(=O)N1C1=CC(Cl)=CC(Cl)=C1 ONUFESLQCSAYKA-UHFFFAOYSA-N 0.000 claims abstract description 42
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 7
- 229920000742 Cotton Polymers 0.000 claims abstract description 3
- 235000021307 Triticum Nutrition 0.000 claims abstract description 3
- 235000013311 vegetables Nutrition 0.000 claims abstract description 3
- 241000209140 Triticum Species 0.000 claims abstract 2
- 239000000375 suspending agent Substances 0.000 claims description 18
- 239000004480 active ingredient Substances 0.000 claims description 12
- 238000009736 wetting Methods 0.000 claims description 11
- 239000000843 powder Substances 0.000 claims description 9
- 239000004562 water dispersible granule Substances 0.000 claims description 8
- 239000004530 micro-emulsion Substances 0.000 claims description 7
- 239000000839 emulsion Substances 0.000 claims description 6
- 238000009472 formulation Methods 0.000 claims description 3
- 240000007594 Oryza sativa Species 0.000 claims description 2
- 235000007164 Oryza sativa Nutrition 0.000 claims description 2
- 235000009566 rice Nutrition 0.000 claims description 2
- 239000005781 Fludioxonil Substances 0.000 abstract description 46
- MUJOIMFVNIBMKC-UHFFFAOYSA-N fludioxonil Chemical compound C=12OC(F)(F)OC2=CC=CC=1C1=CNC=C1C#N MUJOIMFVNIBMKC-UHFFFAOYSA-N 0.000 abstract description 46
- 230000009471 action Effects 0.000 abstract description 4
- 239000004615 ingredient Substances 0.000 abstract 2
- 239000003814 drug Substances 0.000 description 24
- 230000002195 synergetic effect Effects 0.000 description 18
- 240000008067 Cucumis sativus Species 0.000 description 15
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 15
- 230000003449 preventive effect Effects 0.000 description 14
- 239000003795 chemical substances by application Substances 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 239000002131 composite material Substances 0.000 description 9
- 238000012360 testing method Methods 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 238000012545 processing Methods 0.000 description 7
- 231100000419 toxicity Toxicity 0.000 description 7
- 230000001988 toxicity Effects 0.000 description 7
- 239000003899 bactericide agent Substances 0.000 description 6
- 230000003902 lesion Effects 0.000 description 6
- 241000227653 Lycopersicon Species 0.000 description 5
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 4
- 239000000575 pesticide Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 241000123650 Botrytis cinerea Species 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 3
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 3
- 206010034133 Pathogen resistance Diseases 0.000 description 3
- 239000012752 auxiliary agent Substances 0.000 description 3
- 230000000857 drug effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 239000005995 Aluminium silicate Substances 0.000 description 2
- 240000002791 Brassica napus Species 0.000 description 2
- 235000006008 Brassica napus var napus Nutrition 0.000 description 2
- 241000222290 Cladosporium Species 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 2
- 235000016623 Fragaria vesca Nutrition 0.000 description 2
- 240000009088 Fragaria x ananassa Species 0.000 description 2
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 208000031888 Mycoses Diseases 0.000 description 2
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 2
- 241000221662 Sclerotinia Species 0.000 description 2
- 235000009754 Vitis X bourquina Nutrition 0.000 description 2
- 235000012333 Vitis X labruscana Nutrition 0.000 description 2
- 240000006365 Vitis vinifera Species 0.000 description 2
- 235000014787 Vitis vinifera Nutrition 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 239000003905 agrochemical Substances 0.000 description 2
- 235000012211 aluminium silicate Nutrition 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000000306 component Substances 0.000 description 2
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 2
- 239000002270 dispersing agent Substances 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000003912 environmental pollution Methods 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- XUZHLZDRCCUWEV-UHFFFAOYSA-N formaldehyde;methyl naphthalene-1-sulfonate Chemical compound O=C.C1=CC=C2C(S(=O)(=O)OC)=CC=CC2=C1 XUZHLZDRCCUWEV-UHFFFAOYSA-N 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 235000014347 soups Nutrition 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 231100000820 toxicity test Toxicity 0.000 description 2
- JZCUPRBTPVMOJI-UHFFFAOYSA-N 4,5-dihydroimidazole-1-carboxamide Chemical class NC(=O)N1CCN=C1 JZCUPRBTPVMOJI-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000035240 Disease Resistance Diseases 0.000 description 1
- 241000221785 Erysiphales Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 241000221696 Sclerotinia sclerotiorum Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 102000019259 Succinate Dehydrogenase Human genes 0.000 description 1
- 108010012901 Succinate Dehydrogenase Proteins 0.000 description 1
- 102000004357 Transferases Human genes 0.000 description 1
- 108090000992 Transferases Proteins 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical compound [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000000205 computational method Methods 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 238000012136 culture method Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- SYHPANJAVIEQQL-UHFFFAOYSA-N dicarboxy carbonate Chemical compound OC(=O)OC(=O)OC(O)=O SYHPANJAVIEQQL-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- -1 formyl imines Chemical class 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- PSZYNBSKGUBXEH-UHFFFAOYSA-M naphthalene-1-sulfonate Chemical compound C1=CC=C2C(S(=O)(=O)[O-])=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-M 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000000361 pesticidal effect Effects 0.000 description 1
- 238000009700 powder processing Methods 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000009331 sowing Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000004763 spore germination Effects 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 239000011708 vitamin B3 Substances 0.000 description 1
- 235000019160 vitamin B3 Nutrition 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
Abstract
The invention relates to a bactericidal composition, the effective ingredients of which are boscalid (A) and one (B) of iprodione and fludioxonil, and the mass ratio of A to B is 50:1-1:50. The effective ingredients A and B have obvious synergized action after being compounded, and are used for preventing and treating gray mold of crops, such as fruit trees, flowers, cotton, wheat, paddy, rape, vegetables and the like.
Description
Technical field
The present invention relates to a kind of bactericidal composition, especially a kind of combination sterilization composition that contains Boscalid.
Background technology
Gray mold such as gray mold of cucumber and graw mold of tomato etc. are one type of very important diseases on the crops, often cause the heavy losses of crops.According to bibliographical information, because single drug and other unscientific application method have caused gray mold that common pesticides has been produced resistance, the field control effect of medicament declines to a great extent.The increase that resistance produces back formulation rate and spraying times causes peasant burden to increase the weight of and increasing environmental pollution again.Efficiently, the novel germicide of low toxicity, environmental protection, no cross resistance and composition thereof are one of ways of head it off.
Boscalid; English common name boscalid, chemical name: 2-chloro-N-(4 '-chlordiphenyl-2-yl) vitamin PP is the novel nicotinamide bactericide of BASF Aktiengesellschaft's exploitation; Fungicidal spectrum is wide; Have protection and therapeutic action, almost all fungies are had activity, especially efficient to gray mold, stalk break.Boscalid hinders tricarbonic acid cycle, the division of interference cell and growth through suppressing mitochondrial succinate dehydrogenase.Can suppress spore germination, the extension of bacterium pipe, mycelial growth and spore mother cell forms.There is not cross resistance with other bactericide such as iprodiones.Boscalid is the new and effective medicament of control crop gray mold and powdery mildew, but use cost is high and the risk of generation resistance arranged separately.
In view of this, the exploitation synergistic composition that contains the active ingredient Boscalid is prevented and treated gray mold and is had reasonability and feasibility.
Summary of the invention
The objective of the invention is to: provide and use on a kind of suitable agricultural, gray mold had safety, the efficient bactericidal composite of outstanding control efficiency.
For solving the problems of the technologies described above, the inventor is through a large amount of biologicall test screenings, and unexpected discovery Boscalid and iprodione or fludioxonil are composite with certain proportion, and gray mold is had significant synergies.
On the basis of above-mentioned discovery; Through composition is carried out symphyogenetic quantitative analysis; Formed technical scheme of the present invention; Promptly being a kind of active ingredient (A), being another active ingredient (B) with iprodione or fludioxonil with Boscalid, is 50 with (B) mass ratio (A): 1-1: 50, and ratio is 20 preferably: 1-1: 20.
The detailed introduction of said iprodione and fludioxonil is following:
Iprodione, English general iprodione by name, chemical name: 3-(3, the 5-dichlorophenyl)-N-isopropyl-2,4-dioxo imidazoline-1-carboxylic acid amides is dicarboxyl formyl imines series bactericidal agent.Mainly, control the interior signal of cell of many cell functions, disturb carbohydrate to combine entering fungal cell component through the CKIs kinases.Iprodione is a medicament commonly used of preventing and treating gray mold in the market, but active in Boscalid, using dosage is higher separately.
Fludioxonil has another name called and fits when happy English common name Fludioxonil, chemical name: 4-(2,2-two fluoro-1,3-benzo dioxole-4-yl)-1-hydrogen-pyrroles-3-nitrile.Belong to benzene pyroles bactericide, suppress mycelial growth, cause that germ is dead through suppressing glucose phosphorylated transferase.Be tagging property non-internal-absorting bactericide, can prevent and treat seed-borne fungi and soilborne fungal disease, the lasting period is long, and is difficult for and other bactericide generation cross resistance.
The present composition can be prepared into known method and be fit to the formulation that agricultural is used, and comprises wetting powder, water dispersible granules, suspending agent, missible oil, microemulsion, aqueous emulsion; The total content of active ingredient is 5%-80% in the preparation, and all the other are auxiliary element.
The adjuvant that uses in the composition of the present invention comprises that dispersant, wetting agent, antifreezing agent etc. and other are of value to the known substance that active ingredient is stablized and drug effect is brought into play in storing and using; All be the various compositions of using or allow use in the pesticidal preparations always; Do not have special qualification, concrete composition and consumption require to confirm through simple experiment according to prescription.
Composition described in the invention can the finished product preparation form provide, and promptly each material mixes in the composition, and the composition of composition also can provide with single agent form, directly in bucket or jar, directly mixes before the use, is diluted to required concentration then.
Bactericidal composition of the present invention is mainly used in the disease of crops such as fruit tree, flowers, cotton, wheat, paddy rice, rape, vegetables, especially fungal disease control.
Compared with prior art, the beneficial effect of the present invention's generation is: (1) is compared with single agent, and this bactericidal composition is obvious to the disease synergistic effect, has improved control efficiency; (2) because of drug effect improves, the field dosage significantly reduces, and has reduced residue of pesticide and environmental pollution, produces and use cost decline; (3) mechanism of action of active ingredient is different in the bactericidal composition, has reduced the single selection pressure to germ, helps avoiding the disease resistance to produce and delay the generation speed of disease drug resistance.
Embodiment
In order to make the object of the invention, technical scheme and advantage clearer, the present invention describes with following specific embodiment, but the present invention is limited to these examples absolutely not.
The combination of different pesticide active ingredient is carried out composite, be solve some problems in the agricultural chemicals list agent application process at present a kind of effectively with mode efficiently.Different pesticide active ingredients shows three kinds of type of action after mixing usually, and promptly summation action, synergistic effect and antagonism act on but which kind of is specially, and be unpredictable, has only through a large amount of tests and just can know.Compound synergic is well filled a prescription, and can improve actual control efficiency, reduces the usage amount of agricultural chemicals, helps the generation of delaying drug resistance, is one of important means of resistance management.
The present composition is an active ingredient with a kind of (B) in Boscalid (A) and iprodione, the fludioxonil; Combination has obvious role in synergism to gray mold between them; And be not only the simple addition of two kinds of medicament effects, specifically explain with following biologicall test instance.
Biologicall test instance: the composite toxicity test of Boscalid and iprodione or fludioxonil to gray mold of cucumber
Subjects: gray mold of cucumber germ (Botrytis cinerea Pers.)
Pot-culture method is adopted in this test.Sowing sense gray mold of cucumber kind potted plantly grows to 2-4 leaf periods, numbers subsequent use.On the basis of preliminary experiment, active according to medicament, 5-7 series mass concentration is set.Every processing 4 basins evenly spray in the blade face 10ml soup to all wetting, treat that the soup natural air drying is subsequent use.And establish the processing that only contains solvent and surfactant and do not contain effective composition and make blank.Behind the chemicals treatment 24h, on cucumber leaves, evenly spray inoculation botrytis cinerea pers conidial suspension with the crop sprayer.Botrytis cinerea pers conidial suspension process for preparation is following: test is cultured on the suitable culture base with pathogen and produces a large amount of conidiums, with sterile water conidium is washed, and double gauze filters, and is modulated into 1 * 10 behind the microscopy
5The suspension of individual conidium/milliliter (adding a little surfactant) in order to adhering to.Move in the humidistat (relative moisture more than 95%, temperature 20-22 ℃) dark condition after the inoculation and cultivate 24h down, under 20-25 ℃, relative moisture 80%-90% condition, cultivated 7 days then.Add up the lesion area on every strain cucumber leaves, calculate disease index and control efficiency.16 leaves of every processing investigation, stage division is:
The gray mold of cucumber grade scale
0 grade: blade does not have scab;
1 grade: lesion area accounts for below 5% of whole blade area;
3 grades: lesion area accounts for the 6-15% of whole blade area;
5 grades: lesion area accounts for the 16-25% of whole blade area;
7 grades: lesion area accounts for the 26-50% of whole blade area;
9 grades: lesion area accounts for more than 50% of whole blade area.
The drug effect computational methods:
Control efficiency is converted into probability value (y), and liquor strength (μ g/ml) converts logarithm value (x) to, concentration EC in calculating the virulence equation and suppress with method of least squares
50, according to the toxicity index and the co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun medicament.
Actual measurement toxicity index (ATI)=(standard medicament EC
50/ confession reagent agent EC
50) * 100
The percentage composition of B in percentage composition+B medicament toxicity index * mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixture
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (the ATI)/theoretical toxicity index (TTI) of mixture] * 100
When CTC≤80, then the composition performance is for antagonism, and when 80＜CTC＜120, then the composition performance is for summation action, and when CTC>=120, then the composition performance is synergistic effect.
Toxicity test result is referring to table 1 to table 2
The serial proportioning of table 1 Boscalid and iprodione is measured the result to the pot experiment of gray mold of cucumber
Handle EC
50(μ g/mL) ATI TTI co-toxicity coefficient CTC
Boscalid 25.86 100 //
Iprodione 38.35 67.4 //
Boscalid 50: iprodione 1 19.22 134.5 99.4 135.4
Boscalid 20: iprodione 1 14.37 180.0 98.4 182.8
Boscalid 10: iprodione 1 13.37 193.4 97.0 199.3
Boscalid 5: iprodione 1 12.26 210.9 94.6 223.0
Boscalid 1: iprodione 1 10.82 239.0 83.7 285.5
Boscalid 1: iprodione 5 14.44 179.1 72.9 245.8
Boscalid 1: iprodione 10 18.01 143.6 70.4 204.0
Boscalid 1: iprodione 20 20.32 127.3 69.0 184.5
Boscalid 1: iprodione 50 27.02 95.7 68.1 140.6
Result of the test shows, Boscalid and iprodione control gray mold of cucumber, and proportioning is 50: 1-1: in the time of between 50, co-toxicity coefficient all more than 135.4, has synergistic effect; Proportioning is 20: 1-1: in the time of between 20, co-toxicity coefficient all is higher than 182.8, and synergistic effect is more obvious.
The serial proportioning of table 2 Boscalid and fludioxonil is measured the result to the pot experiment of gray mold of cucumber
Handle EC
50(μ g/mL) ATI TTI co-toxicity coefficient CTC
Boscalid 25.86 100 //
Fludioxonil 9.35 276.6 //
Boscalid 50: fludioxonil 1 19.32 133.9 103.5 129.4
Boscalid 20: fludioxonil 1 13.37 193.4 108.4 178.4
Boscalid 10: fludioxonil 1 11.37 227.4 116.1 196.0
Boscalid 5: fludioxonil 1 9.26 279.3 129.4 215.8
Boscalid 1: fludioxonil 1 5.32 486.1 188.3 258.2
Boscalid 1: fludioxonil 5 4.44 582.4 247.1 235.7
Boscalid 1: fludioxonil 10 5.01 516.2 260.5 198.1
Boscalid 1: fludioxonil 20 5.32 486.1 268.2 181.3
Boscalid 1: fludioxonil 50 7.12 363.2 273.1 133.0
Result of the test shows, the composite control gray mold of cucumber of Boscalid and fludioxonil, and proportioning is 50: 1-1: in the time of between 50, co-toxicity coefficient all more than 129.4, has synergistic effect; Proportioning is 20: 1-1: in the time of between 20, co-toxicity coefficient all is higher than 178.4, and synergistic effect is more obvious.
More than measure the result and show that the proportioning of Boscalid and iprodione or fludioxonil is 50: 1-1: in the time of between 50, have synergistic effect, 20: 1-1: in the time of between 20, co-toxicity coefficient is more than 178.4, and synergistic effect is more obvious.
Bactericidal composition of the present invention can be prepared into known method and be fit to wetting powder, suspending agent, water dispersible granules, missible oil, aqueous emulsion, the microemulsion that agricultural is used.Below describe with specific embodiment, percentage is mass percent in the prescription.Active component refers to Boscalid and iprodione or fludioxonil in the present specification, below repeats no more.
One, missible oil processing and application example
Active component and other adjuvant are added in the mixing kettle in the ratio of filling a prescription successively, stir, make missible oil.
Embodiment 1:10.2% Boscalid iprodione missible oil
Boscalid 10%, iprodione 0.2%, N-Methyl pyrrolidone 10%, agricultural newborn 1601#5%, agricultural newborn 500# 5%, xylol complements to 100%.
This embodiment is applied to prevent and treat grey mould fruit rot of strawberry.10.2% Boscalid iprodione missible oil is sprayed by 400 times of (Boscalid valid density is 250 μ g/ml, and iprodione valid density is 5 μ g/ml) thin ups, and the control efficiency of 7 days and 15 days is respectively 94.8%, 92.2% behind the medicine.15% Boscalid suspending agent by 500 times (Boscalid valid density is 300 μ g/ml) and 30% iprodione water dispersible granules by 1000 times (valid density is 300 μ g/ml); In kind use, the preventive effect of 7 days and 15 days is respectively 86.1%, 84.9% and 78.4%, 74.1% behind the medicine.Synergistic effect is obvious behind Boscalid and the iprodione, and the preventive effect of grey mould fruit rot of strawberry obviously is better than single agent.
Two, microemulsion processing and application example
Active component, solvent, cosolvent, emulsifier are added together, make and be dissolved into even oil phase; With water-soluble component and the mixed water that gets of water; Under high-speed stirred, oil phase is mixed with water, make microemulsion.
Embodiment 2:5% Boscalid fludioxonil microemulsion
Boscalid 2.5%, fludioxonil 2.5%, xylol 10%, isopropyl alcohol 10%, agricultural newborn 500# 5%, agricultural newborn 1601# 5%, water complements to 100%.
This embodiment is applied to prevent and treat grape grey mould.5% Boscalid fludioxonil microemulsion is sprayed by 250 times of (Boscalid valid density is 100 μ g/ml, and fludioxonil valid density is 100 μ g/ml) thin ups, and the control efficiency of 7 days and 15 days is respectively 96.3%, 94.3% behind the medicine.20% Boscalid suspending agent by 1000 times (valid density is 200 μ g/ml) and 24% fludioxonil wetting powder by 2000 times (valid density is 120 μ g/ml); In kind use, the preventive effect of 7 days and 15 days is respectively 84.9%, 82.9% and 89.4%, 88.3% behind the medicine.The synergistic effect of the composite back of Boscalid and fludioxonil is obvious, and the preventive effect of grape grey mould obviously is better than single agent.
Three, aqueous emulsion processing and application example
Active component, solvent, emulsifier are added together, make and be dissolved into even oil phase; Oil phase is added in the entry, under high-speed stirred, oil phase is mixed with water, make aqueous emulsion.
Embodiment 3:20% Boscalid iprodione aqueous emulsion
Boscalid 5%, iprodione 15%, xylol 10%, calcium dodecyl benzene sulfonate 5%, agricultural newborn 600# 5%, water complements to 100%.
This embodiment is applied to graw mold of tomato.20% Boscalid iprodione aqueous emulsion is sprayed by 500 times of (Boscalid valid density is 100 μ g/ml, and iprodione valid density is 300 μ g/ml) thin ups, and the control efficiency of 7 days and 15 days is respectively 97.6%, 96.9% behind the medicine.20% Boscalid suspending agent by 1000 times (valid density is 200 μ g/ml) and 20% iprodione suspending agent by 500 times (valid density is 400 μ g/ml); In kind use, the preventive effect of 7 days and 15 days is respectively 88.9%, 85.7% and 86.3%, 84.5% behind the medicine.Synergistic effect is obvious behind Boscalid and the iprodione, and the preventive effect of graw mold of tomato obviously is better than single agent.
Four, suspending agent processing and application example
Each component such as active component, various auxiliary agent and water is even by the mixed of prescription, after grinding and/or high speed shear, obtain suspending agent.
Embodiment 4:30% Boscalid iprodione suspending agent
Boscalid 5%, iprodione 25%, methyl naphthalene sulfonate formaldehyde condensate 10%, Magnesiumaluminumsilicate 1%, white carbon 1%, ethylene glycol 4%, water complements to 100%.
This embodiment is applied to prevent and treat stem rot of cucumber.30% Boscalid iprodione suspending agent is sprayed by 1000 times of (Boscalid valid density is 50 μ g/ml, and iprodione valid density is 250 μ g/ml) thin ups, and the control efficiency of 7 days and 15 days is respectively 92.5%, 90.2% behind the medicine.10% Boscalid suspending agent by 1000 times (valid density is 100 μ g/ml) and 30% iprodione suspending agent by 1000 times (valid density is 300 μ g/ml); In kind use, the preventive effect of 7 days and 15 days is respectively 76.9%, 74.5% and 82.4%, 80.6% behind the medicine.Synergistic effect is obvious behind Boscalid and the iprodione, and the preventive effect of stem rot of cucumber obviously is better than single agent.
Embodiment 5:25% Boscalid fludioxonil suspending agent
Boscalid 20%, fludioxonil 5%, methyl naphthalene sulfonate formaldehyde condensate 10%, xanthans 1%, bentonite 1%, glycerine 4%, water complements to 100%.
This embodiment is applied to prevent and treat cladosporium leaf and fruit mould of tomato.25% Boscalid fludioxonil suspending agent is sprayed by 1000 times of (Boscalid valid density is 200 μ g/ml, and fludioxonil valid density is 50 μ g/ml) thin ups, and the control efficiency of 7 days and 15 days is respectively 92.8%, 91.5% behind the medicine.25% Boscalid wetting powder by 1000 times (valid density is 250 μ g/ml) and 8% fludioxonil suspending agent by 1000 times (valid density is 80 μ g/ml); In kind use, the preventive effect of 7 days and 15 days is respectively 85.9%, 83.2% and 84.4%, 82.6% behind the medicine.The synergistic effect of the composite back of Boscalid and fludioxonil is obvious, and the preventive effect of cladosporium leaf and fruit mould of tomato obviously is better than single agent.
Five, wetting powder processing and application example
Active component, various auxiliary agent and filler etc. are fully mixed in the ratio of prescription, after ultrafine crusher is pulverized, promptly get wetting powder.
Embodiment 6:30.6% Boscalid fludioxonil wetting powder
Boscalid 0.6%, fludioxonil 30%, lauryl sodium sulfate 2%, sodium lignin sulfonate 5%, naphthalene sulfonate 3%, kaolin complements to 100%.
This embodiment is applied to gray mold of cucumber.30.6% Boscalid fludioxonil is sprayed by 3000 times of (Boscalid valid density is 2 μ g/ml, and fludioxonil valid density is 100 μ g/ml) thin ups, and the control efficiency of 7 days and 15 days is respectively 92.1%, 91.3% behind the medicine.20% Boscalid suspending agent by 1000 times (valid density is 200 μ g/ml) and 24% fludioxonil wetting powder by 2000 times (valid density is 120 μ g/ml); In kind use, the preventive effect of 7 days and 15 days is respectively 84.9%, 82.5% and 88.3%, 87.5% behind the medicine.The synergistic effect of the composite back of Boscalid and fludioxonil is obvious, and the preventive effect of gray mold of cucumber obviously is better than single agent.
Six, water dispersant processing and application example
Active component, various auxiliary agent and filler is even by the mixed of prescription, become wetting powder through comminution by gas stream, add a certain amount of water extrusion again and make material.After dry screened, obtain water dispersible granules.
Embodiment 7:80% Boscalid fludioxonil water dispersible granules
Boscalid 60%, fludioxonil 20%, Negel 2%, sodium lignin sulfonate 1%, lauryl sodium sulfate 2%, kaolin complements to 100%.
This embodiment is applied to prevent and treat sclerotinia rot of colza.With 2500 times of 80% Boscalid fludioxonil water dispersible granules (Boscalid valid density is 240 μ g/ml, and fludioxonil valid density is 80 μ g/ml) thin up spraying, the control efficiency of 7 days and 15 days is respectively 98.9%, 96.7% behind the medicine.30% Boscalid water dispersible granules is by 1000 times (valid density is 300 μ g/ml); 10% fludioxonil suspending agent is by 1000 times (valid density is 100 μ g/ml); In kind use, the preventive effect of 7 days and 15 days is respectively 88.2%, 87.3% and 84.6%, 82.4% behind the medicine.The synergistic effect of the composite back of Boscalid and fludioxonil is obvious, and the preventive effect of sclerotinia rot of colza obviously is better than single agent.
Claims (6)
1. bactericidal composition, it is characterized in that: contain active ingredient Boscalid (A) and iprodione (B) in the said bactericidal composition, its mass ratio is 50: 1-1: 50.
2. according to the said bactericidal composition of claim 1, it is characterized in that: active ingredient (A) and mass ratio (B) are 20: 1-1: 20.
3. according to claim 1 or 2 said bactericidal compositions, it is characterized in that: the gross mass percentage composition of active ingredient in bactericidal composition is 5%-80%.
4. according to the said bactericidal composition of claim 3, it is characterized in that: the formulation of said bactericidal composition is missible oil, microemulsion, aqueous emulsion, wetting powder, suspending agent or water dispersible granules.
5. bactericidal composition according to claim 1 is used to prevent and treat the purposes of crop gray mold.
6. the application of bactericidal composition according to claim 5 is characterized in that: said crop is flowers, paddy rice, wheat, fruit tree, cotton, vegetables.
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| CN101237777A (en) * | 2005-06-09 | 2008-08-06 | 拜尔农作物科学股份公司 | Active substance combinations |
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