CN101690487A - Agricultural bactericidal composition - Google Patents
Agricultural bactericidal composition Download PDFInfo
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- CN101690487A CN101690487A CN200910139733A CN200910139733A CN101690487A CN 101690487 A CN101690487 A CN 101690487A CN 200910139733 A CN200910139733 A CN 200910139733A CN 200910139733 A CN200910139733 A CN 200910139733A CN 101690487 A CN101690487 A CN 101690487A
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- bupirimate
- phonetic phenol
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Abstract
The invention relates to a bactericidal composition comprising the effective components of (A) and (B), wherein the (A) is ethirimol or bupirimate, the (B) is one of sanmate, benomyl, thiophanate-methyl or thiabendazole, and the mass proportion of the A to the B is 50:1-1:50. The composition has an obvious synergistic action and can be used for preventing and treating diseases on crops, such as fruit trees, cotton, paddy, wheat, vegetables and the like, especially for preventing and treating fungoid diseases.
Description
Technical field
The present invention relates to a kind of bactericidal composition, especially a kind of bactericidal composition that contains phonetic phenol of second or bupirimate.
Background technology
In recent years, because single drug and the medication of non-science have caused many diseases that the agricultural chemicals of current use has been produced resistance,, become a great problem of chemical control as powdery mildew of cucumber, wheat powdery mildew, grape powdery mildew, sigatoka etc.Simultaneously, frequent dispenser causes peasant burden to increase the weight of and increasing environmental pollution again.Therefore, be badly in need of the bactericide new varieties of efficient, low toxicity, environmental protection.
Phonetic phenol of second (ETHIRMOL) or bupirimate (BUPIRIMATE), they are adenosine deaminase inhibitors, are systemic fungicides, have protection and therapeutic action.Can be absorbed rapidly by plant roots, stem, leaf, and in plant corpus, run to each position, so resistance of rainwater washing against.10～14 days lasting periods after the dispenser.There is not cross resistance with conventional dose.But the control spectrum is narrower, exist to produce resistance risk, and use cost is higher separately.
Carbendazim (CARBENDAZIM), benomyl (BENOMYL), thiophanate-methyl (THIOPHANATE-METHYL), probenazole (THIABENDAZOLE); all belong to benzene (also) imidazoles bactericide; the high-efficiency broad spectrum low toxicity, effective to sac fungi and imperfect fungus, have protection and therapeutic action.The mechanism of action is the formation of spindle in the mitosis of disturbing bacterium, thereby influences cell division.Activity is lower, dosage is big but use separately, is easy to generate resistance.
In view of this, the necessary efficient bactericidal composite that uses on a kind of suitable agricultural that provides.
Summary of the invention
The objective of the invention is to: the Synergistic bactericidal composition that uses on a kind of suitable agricultural, disease had outstanding control efficiency is provided.
For solving the problems of the technologies described above, the inventor is by a large amount of biologicall test screenings, and the unexpected discovery phonetic phenol of second or bupirimate and benzene (also) imidazoles carbendazim etc. are composite with certain proportion, and some diseases are had significant synergies.
On the basis of above-mentioned discovery, through composition is carried out symphyogenetic quantitative analysis and research, formed technical scheme of the present invention, promptly with phonetic phenol of second or bupirimate be a kind of active ingredient (A), a kind of for another active ingredient (B) with in carbendazim, benomyl, thiophanate-methyl, the probenazole, the mass ratio of A and B is 50: 1-1: 50, and ratio is 20 preferably: 1-1: 20.
The present composition can be prepared into known method and be fit to the formulation that agricultural is used, and the total content of active ingredient is 5%-90% in the preparation.
The adjuvant that uses in the composition of the present invention comprises that dispersant, wetting agent, antifreezing agent etc. and other are of value to the known substance that active ingredient is stablized and drug effect is brought into play in storing and using, all be the various compositions of using or allow use in the pesticidal preparations always, be not particularly limited, concrete composition and consumption require to determine by simple experiment according to prescription.
Composition described in the invention can the finished product preparation form provide, and promptly each material mixes in the composition, and the composition of composition also can provide with single agent form, directly directly mixes in bucket or jar before the use, is diluted to required concentration then.
Bactericidal composition of the present invention is mainly used in the disease of crops such as fruit tree, cotton, paddy rice, wheat, vegetables, and especially fungal disease control is as wheat powdery mildew, powdery mildew of cucumber, sigatoka etc.
Compared with prior art, the beneficial effect of the present invention's generation is: (1) is compared with single agent, and this bactericidal composition has tangible synergy to disease, has improved control efficiency; (2) can significantly reduce the field dosage, effectively reduce environmental pollution and residue of pesticide, and reduce and produce and use cost; (3) mechanism of action of active ingredient is different in the bactericidal composition, the generation that helps overcoming the disease resistance He delay disease drug resistance.
Embodiment
In order to make purpose of the present invention, technical scheme and advantage clearer, the present invention describes with following specific embodiment, but the present invention is limited to these examples absolutely not.
The combination of active principles of different agricultural chemicals being carried out composite, is a kind of mode effectively and efficiently that solves some problems in the agricultural chemicals list agent application process at present.The agricultural chemicals of different cultivars shows three kinds of type of action after mixing usually, and promptly summation action, synergistic effect and antagonism act on but which kind of is specially, and be unpredictable, has only by a large amount of tests and just can know.Compound synergic is well filled a prescription, and can improve actual control efficiency, reduces the usage amount of agricultural chemicals, helps the generation of delaying drug resistance, is the important means of integrated control.
The present composition is an active ingredient with the phonetic phenol of second or bupirimate and carbendazim, probenazole, benomyl or thiophanate-methyl, combination has obvious role in synergism to disease between them, and be not only the simple addition of two kinds of medicament effects, specifically be illustrated with following biologicall test example.
Biologicall test example 1: the composite toxicity test of phonetic phenol of second or bupirimate and carbendazim, probenazole, benomyl or thiophanate-methyl to powdery mildew of cucumber
Subjects: powdery mildew of cucumber germ
Pot-culture method is adopted in this test.Sowing sense powdery mildew of cucumber kind potted plantly is cultured to 2-4 leaf periods, numbers standby.With the pure water that is added with a small amount of surface reactive material, draw the fresh spore that covers with on the white powder germ cucumber leaves, making spore concentration is 1 * 10
5Individual/mL spore suspension is standby.On the basis of preliminary experiment,, 5-7 series mass concentration is set according to the medicament activity.Soup is evenly sprayed in the blade face to all wetting, treat that the soup natural air drying is standby.Every processing 3 basins repeat for 4 times, and establish the processing that only contains solvent and surfactant and do not contain effective composition and make blank.24h behind the medicine, inoculation powdery mildew spore.Cultivate 7d in the greenhouse after, add up the lesion area on every strain cucumber seedling blade, the investigation prevention effect is calculated control efficiency with disease index.
Grade scale
0 grade: anosis;
1 grade: the sorus area accounts for below 5% of one-piece blade area;
3 grades: the sorus area accounts for the 6%-10% of one-piece blade area;
5 grades: the sorus area accounts for the 11%-20% of one-piece blade area;
7 grades: the sorus area accounts for the 21%-50% of one-piece blade area;
9 grades: the sorus area accounts for more than 50% of one-piece blade area.
The drug effect computational methods:
Control efficiency is converted into probability value (y), and liquor strength (μ g/ml) converts logarithm value (x) to, calculates concentration EC in virulence equation and the inhibition with method of least squares
50, according to the toxicity index and the co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun medicament.
Actual measurement toxicity index (ATI)=(standard medicament EC
50/ reagent agent EC
50) * 100
The percentage composition of B in percentage composition+B medicament toxicity index * mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixture
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (the ATI)/theoretical toxicity index (TTI) of mixture] * 100
When CTC≤80, then the composition performance is for antagonism, and when 80＜CTC＜120, then the composition performance is for summation action, and when CTC 〉=120, then the composition performance is synergistic effect.
Toxicity test result referring to table 1 to table 5.
The serial proportioning of table 1 bupirimate and carbendazim is to the Toxicity Determination result of powdery mildew of cucumber
| Handle | ??EC 50(μg/mL) | ??ATI | ??TTI | Co-toxicity coefficient CTC |
| Bupirimate | ??14.12 | ??100 | ??/ | ??/ |
| Carbendazim | ??46.15 | ??30.6 | ??/ | ??/ |
| Bupirimate 50: carbendazim 1 | ??10.13 | ??139.4 | ??98.6 | ??141.3 |
| Bupirimate 20: carbendazim 1 | ??9.72 | ??145.3 | ??96.7 | ??150.2 |
| Bupirimate 10: carbendazim 1 | ??8.52 | ??165.7 | ??93.7 | ??176.9 |
| Bupirimate 5: carbendazim 1 | ??7.35 | ??192.1 | ??88.4 | ??217.2 |
| Bupirimate 1: carbendazim 1 | ??9.73 | ??145.1 | ??65.3 | ??222.2 |
| Bupirimate 1: carbendazim 5 | ??12.34 | ??114.4 | ??42.2 | ??271.4 |
| Bupirimate 1: carbendazim 20 | ??15.61 | ??90.5 | ??33.9 | ??266.8 |
| Bupirimate 1: carbendazim 50 | ??30.12 | ??46.9 | ??32.0 | ??146.7 |
Table 1 result of the test shows, the composite powdery mildew of cucumber of preventing and treating of bupirimate and carbendazim, proportioning is 50: 1-1: in the time of between 50, listed proportioning co-toxicity coefficient CTC is more than 141.3, has synergistic effect, and 20: 1-1: in the time of between 20, listed proportioning co-toxicity coefficient all is higher than 150.2, and synergistic effect is more obvious.
The serial proportioning of phonetic phenol of table 2 second and carbendazim is to the Toxicity Determination result of powdery mildew of cucumber
| Handle | ??EC 50(μg/mL) | ??ATI | ??TTI | Co-toxicity coefficient CTC |
| The phonetic phenol of second | ??15.72 | ??100 | ??/ | ??/ |
| Carbendazim | ??46.25 | ??34.0 | ??/ | ??/ |
| The phonetic phenol 50 of second: carbendazim 1 | ??10.13 | ??155.2 | ??98.7 | ??157.2 |
| The phonetic phenol 20 of second: carbendazim 1 | ??9.72 | ??161.7 | ??96.9 | ??167.0 |
| The phonetic phenol 10 of second: carbendazim 1 | ??8.52 | ??184.5 | ??94.0 | ??196.3 |
| The phonetic phenol 5 of second: carbendazim 1 | ??7.35 | ??213.9 | ??89.0 | ??240.3 |
| The phonetic phenol 1 of second: carbendazim 1 | ??9.73 | ??161.6 | ??67.0 | ??241.2 |
| The phonetic phenol 1 of second: carbendazim 5 | ??12.34 | ??127.4 | ??45.0 | ??283.1 |
| The phonetic phenol 1 of second: carbendazim 20 | ??15.61 | ??100.7 | ??37.1 | ??271.2 |
| The phonetic phenol 1 of second: carbendazim 50 | ??30.12 | ??52.2 | ??35.3 | ??147.9 |
Table 2 result of the test shows, the composite powdery mildew of cucumber of preventing and treating of phonetic phenol of second and carbendazim, proportioning is 50: 1-1: in the time of between 50, listed proportioning co-toxicity coefficient CTC is more than 147.9, has synergistic effect, and 20: 1-1: in the time of between 20, listed proportioning co-toxicity coefficient all is higher than 167.0, and synergistic effect is more obvious.
The serial proportioning of phonetic phenol of table 3 second and thiophanate-methyl is to the Toxicity Determination result of powdery mildew of cucumber
| Handle | ??EC 50(μg/mL) | ??ATI | ??TTI | Co-toxicity coefficient CTC |
| The phonetic phenol of second | ??19.12 | ??100 | ??/ | ??/ |
| Thiophanate-methyl | ??46.15 | ??41.4 | ??/ | ??/ |
| The phonetic phenol 50 of second: thiophanate-methyl 1 | ??14.13 | ??135.3 | ??98.9 | ??136.9 |
| The phonetic phenol 20 of second: thiophanate-methyl 1 | ??9.72 | ??196.7 | ??97.2 | ??202.4 |
| The phonetic phenol 10 of second: thiophanate-methyl 1 | ??8.52 | ??224.4 | ??94.7 | ??237.0 |
| The phonetic phenol 5 of second: thiophanate-methyl 1 | ??7.35 | ??260.1 | ??90.2 | ??288.3 |
| Handle | ??EC 50(μg/mL) | ??ATI | ??TTI | Co-toxicity coefficient CTC |
| The phonetic phenol 1 of second: thiophanate-methyl 1 | ??9.23 | ??207.2 | ??70.7 | ??292.9 |
| The phonetic phenol 1 of second: thiophanate-methyl 5 | ??12.34 | ??154.9 | ??51.2 | ??302.7 |
| The phonetic phenol 1 of second: thiophanate-methyl 20 | ??15.61 | ??122.5 | ??44.2 | ??277.0 |
| The phonetic phenol 1 of second: thiophanate-methyl 50 | ??30.12 | ??63.5 | ??42.6 | ??149.1 |
Table 3 result of the test shows, the composite powdery mildew of cucumber of preventing and treating of phonetic phenol of second and thiophanate-methyl, proportioning is 50: 1-1: in the time of between 50, listed proportioning co-toxicity coefficient CTC is more than 136.9, has synergistic effect, and 20: 1-1: in the time of between 20, listed proportioning co-toxicity coefficient all is higher than 202.4, and synergistic effect is more obvious.
The serial proportioning of phonetic phenol of table 4 second and benomyl is to the Toxicity Determination result of powdery mildew of cucumber
| Handle | ??EC 50(μg/mL) | ??ATI | ??TTI | Co-toxicity coefficient CTC |
| The phonetic phenol of second | ??18.12 | ??100 | ??/ | ??/ |
| Benomyl | ??42.15 | ??43.0 | ??/ | ??/ |
| The phonetic phenol 50 of second: benomyl 1 | ??12.13 | ??149.4 | ??98.9 | ??151.1 |
| The phonetic phenol 20 of second: benomyl 1 | ??11.42 | ??158.7 | ??97.3 | ??163.1 |
| The phonetic phenol 10 of second: benomyl 1 | ??10.22 | ??177.3 | ??94.8 | ??187.0 |
| The phonetic phenol 5 of second: benomyl 1 | ??7.35 | ??246.5 | ??90.5 | ??272.4 |
| The phonetic phenol 1 of second: benomyl 1 | ??8.23 | ??220.2 | ??71.5 | ??308.0 |
| The phonetic phenol 1 of second: benomyl 5 | ??10.34 | ??175.2 | ??52.5 | ??333.9 |
| The phonetic phenol 1 of second: benomyl 20 | ??17.61 | ??102.9 | ??45.7 | ??225.1 |
| The phonetic phenol 1 of second: benomyl 50 | ??30.12 | ??60.2 | ??44.1 | ??136.4 |
Table 4 result of the test shows, the composite powdery mildew of cucumber of preventing and treating of phonetic phenol of second and benomyl, proportioning is 50: 1-1: in the time of between 50, listed proportioning co-toxicity coefficient CTC is more than 136.4, has synergistic effect, and 20: 1-1: in the time of between 20, listed proportioning co-toxicity coefficient all is higher than 163.1, and synergistic effect is more obvious.
The serial proportioning of phonetic phenol of table 5 second and probenazole is to the Toxicity Determination result of powdery mildew of cucumber
| Handle | ??EC 50(μg/mL) | ??ATI | ??TTI | Co-toxicity coefficient CTC |
| The phonetic phenol of second | ??18.12 | ??100 | ??/ | ??/ |
| Probenazole | ??35.15 | ??51.6 | ??/ | ??/ |
| The phonetic phenol 50 of second: probenazole 1 | ??12.53 | ??144.6 | ??99.1 | ??146.0 |
| The phonetic phenol 20 of second: probenazole 1 | ??11.23 | ??161.4 | ??97.7 | ??165.2 |
| The phonetic phenol 10 of second: probenazole 1 | ??10.12 | ??179.1 | ??95.6 | ??187.3 |
| The phonetic phenol 5 of second: probenazole 1 | ??8.35 | ??217.0 | ??91.9 | ??236.1 |
| The phonetic phenol 1 of second: probenazole 1 | ??9.23 | ??196.3 | ??75.8 | ??259.1 |
| The phonetic phenol 1 of second: probenazole 5 | ??9.94 | ??182.3 | ??59.6 | ??305.7 |
| The phonetic phenol 1 of second: probenazole 20 | ??13.61 | ??133.1 | ??53.9 | ??247.2 |
| The phonetic phenol 1 of second: probenazole 50 | ??24.12 | ??75.1 | ??52.5 | ??143.1 |
Table 5 result of the test shows, the composite powdery mildew of cucumber of preventing and treating of phonetic phenol of second and probenazole, proportioning is 50: 1-1: in the time of between 50, listed proportioning co-toxicity coefficient CTC is more than 143.1, has synergistic effect, and 20: 1-1: in the time of between 20, listed proportioning co-toxicity coefficient all is higher than 165.2, and synergistic effect is more obvious.
Biologicall test example 2: phonetic phenol of second or bupirimate and carbendazim, benomyl, probenazole, the composite toxicity test of thiophanate-methyl to sigatoka
Subjects: sigatoka bacterium
Growth rate method (Plating) is adopted in test.On the basis of preliminary experiment, handling the sterilising medium that will melt in advance according to test quantitatively places in the aseptic conical flask, getting the 5ml soup from the low concentration to the high concentration successively joins respectively the hot medium of 45ml (PDA medium is housed, 45-50 ℃) conical flask in, after shaking up, treat that medium drops to and pour diameter 90mm glass culture dish when being fit to temperature rapidly into, each culture dish is poured band medicine medium 10ml into.Level leaves standstill, and makes flat board after the cooling.Five repetitions of each concentration.Make blank with the processing that does not contain the medicament effective ingredient.With cultured pathogen, under aseptic condition,, cut the bacterium cake from colony edge with the sterilization card punch of diameter 4mm, with inoculator the bacterium cake is inoculated in the dull and stereotyped central authorities of pastille, will there be one of mycelia to face down and the medium applying, cover the ware lid.Above all operations all carries out sterile working at superclean bench.Be placed on after the processing in 28 ± 0.5 ℃ the constant temperature aseptic culture case and cultivate, take out behind the 5d.Adopt the right-angled intersection method to measure the colony diameter (is unit with the millimeter) that each is handled respectively, calculate the mean value of colony diameter.Calculate and respectively handle the clean amount of growth of mycelia, mycelial growth inhibition rate.
Clean amount of growth (mm)=measurement colony diameter-4
Mycelial growth rate (%)=[(the clean amount of growth of the clean amount of growth-processed group of control group)/clean amount of growth of control group] * 100
The mycelial growth rate conversion is become probability value (y), and liquor strength (μ g/ml) converts logarithm value (x) to, calculates concentration EC in virulence equation and the inhibition with method of least squares
50, according to the toxicity index and the co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun medicament.
Toxicity test result referring to table 6 to table 8
The serial proportioning of table 6 bupirimate and thiophanate-methyl is to the Toxicity Determination result of sigatoka
| Handle | ??EC 50(μg/mL) | ??ATI | ??TTI | Co-toxicity coefficient CTC |
| Bupirimate | ??18.12 | ??100 | ??/ | ??/ |
| Thiophanate-methyl | ??46.35 | ??39.1 | ??/ | ??/ |
| Bupirimate 50: thiophanate-methyl 1 | ??14.13 | ??128.2 | ??98.8 | ??129.8 |
| Bupirimate 20: thiophanate-methyl 1 | ??9.72 | ??186.4 | ??97.1 | ??192.0 |
| Bupirimate 10: thiophanate-methyl 1 | ??8.52 | ??212.7 | ??94.5 | ??225.1 |
| Bupirimate 5: thiophanate-methyl 1 | ??7.35 | ??246.5 | ??89.8 | ??274.4 |
| Bupirimate 1: thiophanate-methyl 1 | ??9.23 | ??196.3 | ??69.5 | ??282.3 |
| Bupirimate 1: thiophanate-methyl 5 | ??12.34 | ??146.8 | ??49.2 | ??298.2 |
| Bupirimate 1: thiophanate-methyl 20 | ??15.61 | ??116.1 | ??42.0 | ??276.4 |
| Bupirimate 1: thiophanate-methyl 50 | ??30.12 | ??60.2 | ??40.3 | ??149.3 |
Table 6 result of the test shows, the composite sigatoka of preventing and treating of bupirimate and thiophanate-methyl, proportioning is 50: 1-1: in the time of between 50, listed proportioning co-toxicity coefficient CTC is more than 129.8, has synergistic effect, and 20: 1-1: in the time of between 20, listed proportioning co-toxicity coefficient all is higher than 192.0, and synergistic effect is more obvious.
The serial proportioning of table 7 bupirimate and benomyl is to the Toxicity Determination result of sigatoka
| Handle | ?EC 50(μg/mL) | ??ATI | ??TTI | Co-toxicity coefficient CTC |
| Bupirimate | ??20.12 | ??100 | ??/ | ??/ |
| Benomyl | ??44.35 | ??45.4 | ??/ | ??/ |
| Bupirimate 50: benomyl 1 | ??15.13 | ??133.0 | ??98.9 | ??134.4 |
| Bupirimate 20: benomyl 1 | ??12.72 | ??158.2 | ??97.4 | ??162.4 |
| Bupirimate 10: benomyl 1 | ??11.52 | ??174.7 | ??95.0 | ??183.8 |
| Bupirimate 5: benomyl 1 | ??10.28 | ??195.7 | ??90.9 | ??215.3 |
| Handle | ?EC 50(μg/mL) | ??ATI | ??TTI | Co-toxicity coefficient CTC |
| Bupirimate 1: benomyl 1 | ??9.43 | ??213.4 | ??72.7 | ??293.6 |
| Bupirimate 1: benomyl 5 | ??11.34 | ??177.4 | ??54.5 | ??325.7 |
| Bupirimate 1: benomyl 20 | ??15.61 | ??128.9 | ??48.0 | ??268.7 |
| Bupirimate 1: benomyl 50 | ??30.12 | ??66.8 | ??46.4 | ??143.8 |
Table 7 result of the test shows, the composite sigatoka of preventing and treating of bupirimate and thiophanate-methyl, proportioning is 50: 1-1: in the time of between 50, listed proportioning co-toxicity coefficient CTC is more than 134.4, has synergistic effect, and 20: 1-1: in the time of between 20, listed proportioning co-toxicity coefficient all is higher than 162.4, and synergistic effect is more obvious.
The serial proportioning of phonetic phenol of table 8 second and probenazole is to the Toxicity Determination result of sigatoka
| Handle | ??EC 50(μ??g/mL) | ??ATI | ??TTI | Co-toxicity coefficient CTC |
| The phonetic phenol of second | ??21.12 | ??100 | ??/ | ??/ |
| Probenazole | ??42.35 | ??49.9 | ??/ | ??/ |
| The phonetic phenol 50 of second: probenazole 1 | ??16.13 | ??130.9 | ??99.0 | ??132.2 |
| The phonetic phenol 20 of second: probenazole 1 | ??14.72 | ??143.5 | ??97.6 | ??147.0 |
| The phonetic phenol 10 of second: probenazole 1 | ??12.52 | ??168.7 | ??95.4 | ??176.7 |
| The phonetic phenol 5 of second: probenazole 1 | ??10.28 | ??205.4 | ??91.6 | ??224.2 |
| The phonetic phenol 1 of second: probenazole 1 | ??9.73 | ??217.1 | ??74.9 | ??289.7 |
| The phonetic phenol 1 of second: probenazole 5 | ??10.34 | ??204.3 | ??58.2 | ??350.8 |
| The phonetic phenol 1 of second: probenazole 20 | ??16.61 | ??127.2 | ??52.3 | ??243.3 |
| The phonetic phenol 1 of second: probenazole 50 | ??31.12 | ??67.9 | ??50.9 | ??133.5 |
Table 8 result of the test shows, the composite sigatoka of preventing and treating of phonetic phenol of second and probenazole, proportioning is 50: 1-1: in the time of between 50, listed proportioning co-toxicity coefficient CTC is more than 132.2, has synergistic effect, and 20: 1-1: in the time of between 20, listed proportioning co-toxicity coefficient all is higher than 147.0, and synergistic effect is more obvious.
Above measurement result shows, the proportioning of phonetic phenol of second or bupirimate and carbendazim, benomyl, thiophanate-methyl or probenazole is 50: 1-1: in the time of between 50, have synergistic effect, 20: 1-1: in the time of between 20, synergistic effect is more obvious, and co-toxicity coefficient is more than 147.0.
Bactericidal composition of the present invention can be prepared into known method and be fit to wetting powder, suspending agent or the water dispersible granules that agricultural is used.Below describe with specific embodiment, percentage is mass percent in the prescription.The phonetic phenol of present specification middle finger bupirimate/second and benzimidazole germicide carbendazim, benomyl, thiophanate-methyl or probenazole, former medicine refer to active component chemosynthesis, unprocessed, below repeat no more.
Embodiment 1:25.5% bupirimate carbendazim suspending agent
Bupirimate 25%
Carbendazim 0.5%
Methyl naphthalene sulfonate formaldehyde condensate (wetting dispersing agent) 10%
Xanthans (thickener) 1%
Bentonite (carrier) 1%
Glycerine (antifreeze) 1%
Water complements to 100%.
The ratio of each component such as the former medicine of active component, wetting dispersing agent, thickener, carrier and water in prescription mixed, after grinding and/or high speed shear, obtain 25.5% bupirimate carbendazim suspending agent.
This embodiment is applied to prevent and treat powdery mildew of cucumber.25.5% bupirimate carbendazim suspending agent is sprayed by 1250 times of (bupirimate valid density is 200 μ g/ml, and carbendazim valid density is 4 μ g/ml) thin ups, and the control efficiency of 7 days and 15 days is respectively 98.3%, 96.2% behind the medicine.25% bupirimate suspending agent by 1000 times (valid density is 250 μ g/ml) and 25% carbendazim suspending agent by 1000 times (valid density is 250 μ g/ml), with using with quadrat method, the preventive effect of 7 days and 15 days is respectively 92.1%, 89.9% and 80.9%, 78.6% behind the medicine.The synergistic effect of the composite back of bupirimate and carbendazim is obvious, to the preventive effect of powdery mildew of cucumber significantly better than single agent.
Embodiment 2:50% bupirimate thiophanate-methyl suspending agent
Bupirimate 20%
Thiophanate-methyl 30%
Methyl naphthalene sulfonate formaldehyde condensate (wetting dispersing agent) 10%
Xanthans (thickener) 1%
Bentonite (carrier) 1%
Glycerine (antifreeze) 1%
Water complements to 100%.
The ratio of each component such as former medicine, wetting dispersing agent, thickener, antifreeze, carrier and water in prescription mixed, after grinding and/or high speed shear, obtain 50% bupirimate thiophanate-methyl suspending agent.
This embodiment is applied to prevent and treat wheat powdery mildew.(bupirimate valid density is 100 μ g/ml by 2000 times with 50% bupirimate thiophanate-methyl suspending agent, thiophanate-methyl valid density is 125 μ g/ml) thin up spraying, the control efficiency of 7 days and 15 days is respectively 96.7%, 93.9% behind the medicine.4% bupirimate suspending agent by 200 times (valid density is 200 μ g/ml) and 20% thiophanate-methyl wetting powder by 1000 times (valid density is 200 μ g/ml), with using with quadrat method, the preventive effect of 7 days and 15 days is respectively 87.3%, 86.2% and 78.8%, 77.4% behind the medicine.The synergistic effect of the composite back of bupirimate and thiophanate-methyl is obvious, to the preventive effect of wheat powdery mildew significantly better than single agent.
The phonetic phenol carbendazol wettable powder of embodiment 3:51% second
The phonetic phenol 1% of second
Carbendazim 50%
Lauryl sodium sulfate (wetting agent) 2%
Sodium lignin sulfonate (dispersant) 5%
Naphthalene sulfonate (dispersant) 3%
Kaolin (filler) complements to 100%.
Active component, various auxiliary agent and filler etc. are fully mixed in the ratio of prescription, after ultrafine crusher is pulverized, promptly get the phonetic phenol carbendazol wettable powder of 51% second.
This embodiment uses joint melon powdery mildew.The phonetic phenol carbendazol wettable powder of 51% second is sprayed by 1500 times of (the phonetic phenol valid density of second is 12.5 μ g/ml, and carbendazim valid density is 625 μ g/ml) thin ups, and the control efficiency of 7 days and 15 days is respectively 89.7%, 86.5% behind the medicine.The phonetic phenol wetting powder of 10% second is pressed 1000 times (300 μ g/ml) by 1000 times (valid density is 100 μ g/ml) and 30% carbendazol wettable powder, with using with quadrat method, the preventive effect of 7 days and 15 days is respectively 80.9%, 78.9% and 76.9%, 73.5% behind the medicine.The synergistic effect of the composite back of phonetic phenol of second and carbendazim is obvious, to the preventive effect of joint melon powdery mildew significantly better than single agent.
Embodiment 4:80% bupirimate thiophanate-methyl water dispersible granules
Bupirimate 15%
Thiophanate-methyl 65%
Negel (dispersant) 2%
Sodium lignin sulfonate (dispersant) 1%
Sulfuric acid amine (disintegrant) 2%
Lauryl sodium sulfate (wetting agent) 2%
Kaolin (filler) is to 100%
Active component, dispersant, disintegrant, wetting agent and the filler ratio in prescription is mixed, become wetting powder, add a certain amount of water mixing extruding again and make material through comminution by gas stream.Obtain 90% bupirimate thiophanate-methyl water dispersible granules after the drying screening.
This embodiment is applied to prevent and treat sigatoka.(bupirimate valid density is 100 μ g/ml with 3000 times of 90% bupirimate thiophanate-methyl water dispersible granules, thiophanate-methyl valid density is 200 μ g/ml) thin up spraying, the control efficiency of 7 days and 15 days is respectively 96.9%, 95.7% behind the medicine.30% bupirimate water dispersible granules by 1500 times (valid density is 200 μ g/ml) and 60% thiophanate-methyl wetting powder by 2000 times (valid density is 300 μ g/ml), with using with quadrat method, the preventive effect of 7 days and 15 days is respectively 87.5%, 86.9% and 80.6%, 78.4% behind the medicine.The synergistic effect of the composite back of bupirimate and thiophanate-methyl is obvious, to the preventive effect of sigatoka significantly better than single agent.
The phonetic phenol benomyl of embodiment 5:40% second wetting powder
The phonetic phenol 15% of second
Benomyl 25%
Lauryl sodium sulfate (wetting agent) 2%
Sodium lignin sulfonate (dispersant) 5%
Naphthalene sulfonate (dispersant) 3%
Kaolin (filler) complements to 100%.
Active component, various auxiliary agent and filler etc. are fully mixed in the ratio of prescription, after ultrafine crusher is pulverized, promptly get the phonetic phenol carbendazol wettable powder of 40% second.
This embodiment uses joint melon powdery mildew.The phonetic phenol benomyl of 40% second wetting powder is sprayed by 1000 times of (the phonetic phenol valid density of second is 150 μ g/ml, and benomyl valid density is 250 μ g/ml) thin ups, and the control efficiency of 7 days and 15 days is respectively 97.2%, 96.3% behind the medicine.The phonetic phenol suspending agent of 20% second by 1000 times (valid density is 200 μ g/ml) and 40% benomyl wetting powder by 1000 times (valid density is 400 μ g/ml), with using with quadrat method, the preventive effect of 7 days and 15 days is respectively 90.9%, 88.9% and 78.4%, 77.3% behind the medicine.The synergistic effect of the composite back of phonetic phenol of second and benomyl is obvious, to the preventive effect of joint melon powdery mildew significantly better than single agent.
The phonetic phenol probenazole of embodiment 6:45% second suspending agent
The phonetic phenol 15% of second
Probenazole 30%
Methyl naphthalene sulfonate formaldehyde condensate (wetting dispersing agent) 10%
Xanthans (thickener) 1%
Bentonite (carrier) 1%
Glycerine (antifreeze) 1%
Water complements to 100%.
The ratio of each component such as former medicine, wetting dispersing agent, thickener, carrier and water in prescription mixed, after grinding and/or high speed shear, obtain the phonetic phenol probenazole of 45% second suspending agent.
This embodiment uses grape powdery mildew.The phonetic phenol probenazole of 45% second suspending agent is sprayed by 1000 times of (the phonetic phenol valid density of second is 150 μ g/ml, and probenazole valid density is 300 μ g/ml) thin ups, and the control efficiency of 7 days and 15 days is respectively 98.9%, 97.7% behind the medicine.The phonetic phenol suspending agent of 20% second by 1000 times (valid density is 200 μ g/ml) and 40% probenazole wetting powder by 1000 times (valid density is 400 μ g/ml), with using with quadrat method, the preventive effect of 7 days and 15 days is respectively 90.9%, 87.3% and 82.8%, 81.3% behind the medicine.The synergistic effect of the composite back of phonetic phenol of second and probenazole is obvious, to the preventive effect of grape powdery mildew significantly better than single agent.
Claims (6)
1. bactericidal composition is characterized in that: active ingredient is (A) and (B) 2 kinds, (A) is phonetic phenol of second or bupirimate, (B) is one of carbendazim, benomyl, thiophanate-methyl or probenazole, and the mass ratio of A and B is 50: 1-1: 50.
2. according to claim 1, it is characterized in that: the mass ratio of effective constituents A and B is 20: 1-1: 20.
3. according to claim 1 or 2, it is characterized in that: the gross mass percentage composition of active ingredient is 5%-90% in the composition.
According in the claim 1 to 3 each, it is characterized in that: also contain the pesticidal preparations auxiliary element in the described bactericidal composition, be fit to the formulation that agricultural is used so that bactericidal composition made.
5. according to claim 4, it is characterized in that: the formulation of described bactericidal composition is wetting powder, suspending agent or water dispersible granules.
6. the described bactericidal composition of claim 1, the application on control of crop disease.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101715775B (en) * | 2009-11-30 | 2013-04-17 | 福建新农大正生物工程有限公司 | Sterilizing composition containing ethirimol |
| CN101715777B (en) * | 2010-01-12 | 2013-05-08 | 广东中迅农科股份有限公司 | Pesticide composition containing ethirimol and thiophanate-methyl, and application thereof |
| CN104938509A (en) * | 2015-06-09 | 2015-09-30 | 柳州市天姿园艺有限公司 | Composition for preventing and controlling leaf spot of cymbidium faberi Rolfe |
| CN108684693A (en) * | 2018-06-02 | 2018-10-23 | 允发化工（上海）有限公司 | A kind of modified benomyl wettable powder and its preparation method and application |
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|---|---|---|---|---|
| US20050227956A1 (en) * | 2004-04-13 | 2005-10-13 | Ying Wang | Control of mold growth on wood |
| CN101087529A (en) * | 2004-12-23 | 2007-12-12 | 巴斯福股份公司 | Fungicidal mixtures |
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- 2009-06-27 CN CN200910139733A patent/CN101690487A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050227956A1 (en) * | 2004-04-13 | 2005-10-13 | Ying Wang | Control of mold growth on wood |
| CN101087529A (en) * | 2004-12-23 | 2007-12-12 | 巴斯福股份公司 | Fungicidal mixtures |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101715775B (en) * | 2009-11-30 | 2013-04-17 | 福建新农大正生物工程有限公司 | Sterilizing composition containing ethirimol |
| CN101715777B (en) * | 2010-01-12 | 2013-05-08 | 广东中迅农科股份有限公司 | Pesticide composition containing ethirimol and thiophanate-methyl, and application thereof |
| CN104938509A (en) * | 2015-06-09 | 2015-09-30 | 柳州市天姿园艺有限公司 | Composition for preventing and controlling leaf spot of cymbidium faberi Rolfe |
| CN108684693A (en) * | 2018-06-02 | 2018-10-23 | 允发化工（上海）有限公司 | A kind of modified benomyl wettable powder and its preparation method and application |
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