CN101658179A - Complex bactericidal composition containing cyazofamid - Google Patents
Complex bactericidal composition containing cyazofamid Download PDFInfo
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Abstract
The invention relates to a bactericidal composition, the active ingredients are cyazofamid (A) and a protective fungicide (B), the weight ratio of A to B is 30:1-1:80; and the protective fungicide B which can be used for the composition comprises chlorothalonil, thiram, ziram, mancozeb, zineb, propineb, amobam and metiram. The composition has obvious synergistic effect and can be used for the disease control of the crops of fruit trees, flowers, cotton, wheat, rice, rapeseed, vegetables and the like, especially the diseases of oomycetes.
Description
Technical field
The present invention relates to a kind of bactericidal composition, especially a kind of combination sterilization composition that contains cyanogen frost azoles.
Background technology
In recent years, because single drug and other unscientific application method have caused many diseases such as cucumber downy mildew, tomato late blight etc. that a lot of agricultural chemicals of current use have been produced resistance, become a great problem of chemical control.Simultaneously, frequent dispenser causes peasant economy burden and increasing environmental pollution again.Performance is particularly outstanding in the disease chemical control that Oomycete causes.Because in the control of oomycetes diseases such as downy mildew, selectable medicament is also few, single drug and repeated drug taking phenomenon are quite obvious.The bactericidal composition of synergy can solve these difficult problems.
The English common name Cyazofamid of cyanogen frost azoles, chemical name 4-chloro-2-cyano group-5-p-methylphenyl-imidazoles-1-N, N-dimethyl methyl acid amides, a kind of mitochondrial respiratory inhibitor by Japanese Ishihara Sangyo Kaisha, Ltd. Development and Production, act on the Qi site among the cytochrome b cl, be different from methoxy acrylate (being Q0 inhibitor among the cytochrome b cl).It is active that cyanogen frost azoles has good protection, and the lasting period is long, and resistance of rainwater washing against, also has certain interior suction and therapeutic activity.Cyanogen frost azoles all has effect to all vegetative stages of oomycetes, can prevent and treat downy mildew and eqpidemic disease.If can obtain some good synergistic formulas with some other composite reagent, then can improve the integral formulation drug effect on the one hand, can delay the speed that cyanogen frost azoles produces resistance on the other hand to a certain extent.At present cyanogen frost azoles and protective fungicide composite still do not have report.
In view of this, the necessary safety, the highly efficiency compositional bactericidal composition that contain cyanogen frost azoles that uses on a kind of suitable agricultural that provide.
Summary of the invention
The objective of the invention is to: the safety, the synergistic complex bactericidal composition that contain cyanogen frost azoles that use on a kind of suitable agricultural, the Oomycete disease had outstanding control efficiency are provided.
For solving the problems of the technologies described above, the inventor is by a large amount of biologicall test screenings, a kind of (B) in unexpected discovery cyanogen frost azoles (A) and tpn, tmtd, ziram, mancozeb, zineb, Propineb, ambam, the Carbatene is composite with certain proportion, and the Oomycete disease is had significant synergies.Tpn, tmtd, ziram, mancozeb, zineb, Propineb, ambam, these several medicaments of Carbatene all are the protectiveness medicaments commonly used of controlling plant diseases; the mechanism of action and cyanogen frost azoles is different, (A) may be from effect of (A) pharmaceutical treatment and (B) the coefficient result of medicament protective effect with the synergistic effect of (B) the composite plant disease that Oomycete is caused.
On the basis of above-mentioned discovery, through composition is carried out symphyogenetic quantitative analysis, formed technical scheme of the present invention, promptly be a kind of active ingredient, be another active ingredient with a kind of (B) in tpn, tmtd, ziram, mancozeb, zineb, Propineb, ambam, the Carbatene with cyanogen frost azoles (A), (A) be 30 with (B) mass ratio: 1-1: 80, ratio is 10 preferably: 1-1: 30.The present composition can be prepared into known method and be fit to the formulation that agricultural is used, and comprises suspending agent, wetting powder, water dispersible granules, and the total content of active ingredient is 10%-90% in the preparation.
The adjuvant that uses in the composition of the present invention comprises that dispersant, wetting agent, carrier etc. and other are of value to the known substance that active ingredient is stablized and drug effect is brought into play in storing and using, all be the various compositions of using or allow use in the pesticidal preparations always, be not particularly limited, concrete composition and consumption require to determine by simple experiment according to prescription.
Composition described in the invention can the finished product preparation form provide, and promptly each material mixes in the composition, and the composition of composition also can provide with single agent form, directly directly mixes in bucket or jar before the use, is diluted to required concentration then.
Bactericidal composition of the present invention is mainly used in the disease of crops such as fruit tree, flowers, cotton, wheat, paddy rice, rape, vegetables, especially oomycetes disease control.
Compared with prior art, the beneficial effect of the present invention's generation is: (1) is compared with single agent, and this bactericidal composition has tangible synergy to disease, has improved control efficiency; (2) can significantly reduce the field dosage, effectively reduce environmental pollution and residue of pesticide, reduce and produce and use cost; (3) mechanism of action of active ingredient is different in the bactericidal composition, the generation that helps overcoming the disease resistance He delay disease drug resistance.
Embodiment
In order to make purpose of the present invention, technical scheme and advantage clearer, the present invention describes with following specific embodiment, but the present invention is limited to these examples absolutely not.
The combination of active principles of different agricultural chemicals being carried out composite, is a kind of mode effectively and efficiently that solves some problems in the agricultural chemicals list agent application process at present.The agricultural chemicals of different cultivars shows three kinds of type of action after mixing usually, and promptly summation action, synergistic effect and antagonism act on but which kind of is specially, and be unpredictable, has only by a large amount of tests and just can know.Compound synergic is well filled a prescription, and can improve actual control efficiency, reduces the usage amount of agricultural chemicals, helps the generation of delaying drug resistance, is the important means of integrated control.
The present composition is a kind of active ingredient with cyanogen frost azoles (A), with a kind of (B) in tpn, tmtd, ziram, mancozeb, zineb, Propineb, ambam, the Carbatene is active ingredient, combination has obvious role in synergism to the Oomycete disease between them, and be not only the simple addition of two kinds of medicament effects, specifically be illustrated with following biologicall test example.
Biologicall test example 1: cyanogen frost azoles and the composite toxicity test of tpn, tmtd, mancozeb or Propineb to cucumber downy mildew
Subjects: cucumber downy mildew germ
Pot-culture method is adopted in this test.Dip in the sporangium that the distilled water of getting about 10 ℃ washes the cucumber leaves back side that has Pseudoperonospora cubensis of picking up from the field with writing brush, be made into 3 * 10
5The suspension of individual sporangium/mL.Choose two leaf period cucumber seedlings of growing way unanimity, each processing selects for use 5 basins for examination melon seedling, sprays the about 5mL of every processing under 50PSI pressure with the Potter spray tower.Each medicament is provided with 5 concentration gradients, is blank with what spray the equivalent clear water.Spray inoculation bacterium of downy mildew of cucumber sporangia suspension behind the chemicals treatment 24h, after the inoculation cucumber seedling placed climatic cabinate (relative moisture 100%, temperature 15-20 ℃) cultivate, keep 15-24 ℃ of temperature, relative moisture about 90% to preserve moisture and bring out behind the 24h, 5d " Invest, Then Investigate " disease index, and calculate control efficiency.
Grade scale
0 grade: blade does not have scab;
1 grade: lesion area accounts for below 5% of whole blade area;
3 grades: lesion area accounts for the 6-10% of whole blade area;
5 grades: lesion area accounts for the 11-25% of whole blade area;
7 grades: lesion area accounts for the 26-50% of whole blade area;
9 grades: lesion area accounts for more than 50% of whole blade area.
The drug effect computational methods:
Control efficiency is converted into probability value (y), and liquor strength (μ g/ml) converts logarithm value (x) to, calculates concentration EC in virulence equation and the inhibition with method of least squares
50, according to the toxicity index and the co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun medicament.
Actual measurement toxicity index (ATI)=(standard medicament EC
50/ reagent agent EC
50) * 100
The percentage composition of B in percentage composition+B medicament toxicity index * mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixture
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (the ATI)/theoretical toxicity index (TTI) of mixture] * 100
When CTC≤80, then the composition performance is for antagonism, and when 80＜CTC＜120, then the composition performance is for summation action, and when CTC 〉=120, then the composition performance is synergistic effect.
Toxicity test result referring to table 1 to table 4
The serial proportioning of table 1 cyanogen frost azoles and tpn is to the Toxicity Determination result of cucumber downy mildew
| Handle | ??EC 50(μg/mL) | ??ATI | ??TTI | Co-toxicity coefficient CTC |
| Cyanogen frost azoles | ??0.37 | ??100 | ??/ | ??/ |
| Tpn | ??60.67 | ??0.6 | ??/ | ??/ |
| Cyanogen frost azoles 30: tpn 1 | ??0.29 | ??127.6 | ??96.8 | ??131.8 |
| Cyanogen frost azoles 20: tpn 1 | ??0.25 | ??148.0 | ??95.3 | ??155.4 |
| Cyanogen frost azoles 10: tpn 1 | ??0.21 | ??176.2 | ??91.0 | ??193.7 |
| Cyanogen frost azoles 5: tpn 1 | ??0.19 | ??194.7 | ??83.4 | ??233.4 |
| Cyanogen frost azoles 1: tpn 1 | ??0.28 | ??132.1 | ??50.3 | ??262.7 |
| Cyanogen frost azoles 1: tpn 5 | ??0.68 | ??54.4 | ??17.2 | ??316.8 |
| Cyanogen frost azoles 1: tpn 10 | ??0.68 | ??54.4 | ??9.6 | ??564.1 |
| Cyanogen frost azoles 1: tpn 20 | ??3.09 | ??12.0 | ??5.3 | ??224.1 |
| Cyanogen frost azoles 1: tpn 30 | ??4.68 | ??7.9 | ??3.8 | ??207.2 |
| Cyanogen frost azoles 1: tpn 50 | ??8.85 | ??4.2 | ??2.6 | ??163.4 |
| Cyanogen frost azoles 1: tpn 80 | ??14.86 | ??2.5 | ??1.8 | ??135.5 |
Result of the test shows, cyanogen frost azoles and chlorothalonil compound control cucumber downy mildew, and proportioning is 50: 1-1: in the time of between 80, co-toxicity coefficient all more than 131.8, has synergistic effect, and 10: 1-1: in the time of between 30, co-toxicity coefficient all is higher than 193.7, and synergistic effect is more obvious.
The serial proportioning of table 2 cyanogen frost azoles and tmtd is to the Toxicity Determination result of cucumber downy mildew
| Handle | ??EC 50(μg/mL) | ??ATI | ??TTI | Co-toxicity coefficient CTC |
| Cyanogen frost azoles | ??0.37 | ??100 | ??/ | ??/ |
| Tmtd | ??56.35 | ??0.7 | ??/ | ??/ |
| Cyanogen frost azoles 30: tmtd 1 | ??0.28 | ??132.1 | ??96.8 | ??136.5 |
| Cyanogen frost azoles 20: tmtd 1 | ??0.24 | ??154.2 | ??95.3 | ??161.8 |
| Cyanogen frost azoles 10: tmtd 1 | ??0.2 | ??185.0 | ??91.0 | ??203.4 |
| Cyanogen frost azoles 5: tmtd 1 | ??0.18 | ??205.6 | ??83.4 | ??246.3 |
| Cyanogen frost azoles 1: tmtd 1 | ??0.27 | ??137.0 | ??50.3 | ??272.3 |
| Cyanogen frost azoles 1: tmtd 5 | ??0.68 | ??54.4 | ??17.2 | ??316.1 |
| Cyanogen frost azoles 1: tmtd 10 | ??1.08 | ??34.3 | ??9.7 | ??353.6 |
| Cyanogen frost azoles 1: tmtd 20 | ??2.09 | ??17.7 | ??5.4 | ??328.6 |
| Cyanogen frost azoles 1: tmtd 30 | ??4.96 | ??7.5 | ??3.9 | ??193.2 |
| Cyanogen frost azoles 1: tmtd 50 | ??8.89 | ??4.2 | ??2.6 | ??159.8 |
| Cyanogen frost azoles 1: tmtd 80 | ??14.86 | ??2.5 | ??1.9 | ??132.2 |
Result of the test shows, cyanogen frost azoles and the composite control cucumber downy mildew of tmtd, and proportioning is 30: 1-1: in the time of between 80, co-toxicity coefficient all more than 132.2, has synergistic effect, and 10: 1-1: in the time of between 30, co-toxicity coefficient all is higher than 193.2, and synergistic effect is more obvious.
The serial proportioning of table 3 cyanogen frost azoles and mancozeb is to the Toxicity Determination result of cucumber downy mildew
| Handle | ??EC 50(μg/mL) | ??ATI | ??TTI | Co-toxicity coefficient CTC |
| Cyanogen frost azoles | ??0.33 | ??100 | ??/ | ??/ |
| Mancozeb | ??76.35 | ??0.4 | ??/ | ??/ |
| Cyanogen frost azoles 30: mancozeb 1 | ??0.26 | ??126.9 | ??96.8 | ??131.1 |
| Cyanogen frost azoles 20: mancozeb 1 | ??0.21 | ??157.1 | ??95.3 | ??165.0 |
| Cyanogen frost azoles 10: mancozeb 1 | ??0.18 | ??183.3 | ??90.9 | ??201.6 |
| Cyanogen frost azoles 5: mancozeb 1 | ??0.16 | ??206.3 | ??83.4 | ??247.3 |
| Cyanogen frost azoles 1: mancozeb 1 | ??0.23 | ??143.5 | ??50.2 | ??285.7 |
| Cyanogen frost azoles 1: mancozeb 5 | ??0.64 | ??51.6 | ??17.0 | ??302.8 |
| Cyanogen frost azoles 1: mancozeb 10 | ??1.27 | ??26.0 | ??9.5 | ??274.0 |
| Cyanogen frost azoles 1: mancozeb 20 | ??2.49 | ??13.3 | ??5.2 | ??256.2 |
| Cyanogen frost azoles 1: mancozeb 30 | ??3.96 | ??8.3 | ??3.6 | ??228.7 |
| Cyanogen frost azoles 1: mancozeb 50 | ??8.69 | ??3.8 | ??2.4 | ??159.3 |
| Cyanogen frost azoles 1: mancozeb 80 | ??15.13 | ??2.2 | ??1.7 | ??131.3 |
Result of the test shows, cyanogen frost azoles and the composite control cucumber downy mildew of mancozeb, and proportioning is 30: 1-1: in the time of between 80, co-toxicity coefficient has synergistic effect more than 131.1, and 10: 1-1: in the time of between 30, co-toxicity coefficient all is higher than 201.6, and synergistic effect is more obvious.
The serial proportioning of table 4 cyanogen frost azoles and Propineb is to the Toxicity Determination result of cucumber downy mildew
| Handle | ??EC 50(μg/mL) | ??ATI | ??TTI | Co-toxicity coefficient CTC |
| Cyanogen frost azoles | ??0.37 | ??100 | ??/ | ??/ |
| Propineb | ??56.35 | ??0.7 | ??/ | ??/ |
| Cyanogen frost azoles 30: Propineb 1 | ??0.28 | ??132.1 | ??96.8 | ??136.5 |
| Cyanogen frost azoles 20: Propineb 1 | ??0.24 | ??154.2 | ??95.3 | ??161.8 |
| Cyanogen frost azoles 10: Propineb 1 | ??0.2 | ??185.0 | ??91.0 | ??203.4 |
| Cyanogen frost azoles 5: Propineb 1 | ??0.18 | ??205.6 | ??83.4 | ??246.3 |
| Cyanogen frost azoles 1: Propineb 1 | ??0.27 | ??137.0 | ??50.3 | ??272.3 |
| Cyanogen frost azoles 1: Propineb 5 | ??0.68 | ??54.4 | ??17.2 | ??316.1 |
| Cyanogen frost azoles 1: Propineb 10 | ??1.08 | ??34.3 | ??9.7 | ??353.6 |
| Cyanogen frost azoles 1: Propineb 20 | ??2.09 | ??17.7 | ??5.4 | ??328.6 |
| Cyanogen frost azoles 1: Propineb 30 | ??4.96 | ??7.5 | ??3.9 | ??193.2 |
| Cyanogen frost azoles 1: Propineb 50 | ??8.89 | ??4.2 | ??2.6 | ??159.8 |
| Cyanogen frost azoles 1: Propineb 80 | ??14.86 | ??2.5 | ??1.9 | ??132.2 |
Result of the test shows, cyanogen frost azoles and the composite control cucumber downy mildew of Propineb, and proportioning is 30: 1-1: in the time of between 80, co-toxicity coefficient all more than 132.2, has synergistic effect, and 10: 1-1: in the time of between 30, co-toxicity coefficient all is higher than 193.2, and synergistic effect is more obvious.
Biologicall test example 2: cyanogen frost azoles and the composite toxicity test of ziram, zineb, ambam or Carbatene to tomato late blight
Subjects: tomato late blight germ
Pot-culture method is adopted in test.Tomato is potted plant to grow to 2-4 leaf periods, numbers standby.To test with pathogen and on the suitable culture base, cultivate, after waiting to produce sporangium, sporangium be washed, filter, make 1 * 10 with double gauze with sterile water
5Individual sporangium/mL sporangia suspension.According to the medicament activity,, 5-7 series mass concentration is set according to the medicament activity.Soup is evenly sprayed in the blade face to all wetting, treat that the soup natural air drying is standby.Every processing 3 basins repeat for 4 times, and establish a bonding solvent and surfactant and blank is made in the processing that do not contain effective composition.Behind the chemicals treatment 24h, on tomato leaf, evenly spray inoculation with the crop sprayer.After the inoculation,, cultivated 7 days under the condition of relative moisture more than 90% at temperature 18-20 ℃.Add up the lesion area on every strain tomato leaf, the investigation prevention effect.30 leaves are investigated in every processing at least, and stage division is:
0 grade; Anosis;
1 grade: a small amount of little scab is only arranged on the blade, and scab accounts for leaf area below 10%;
3 grades: scab accounts for leaf area 10%-25% on the blade;
5 grades: scab accounts for leaf area 26%-50% on the blade;
7 grades: scab accounts for leaf area more than 50% on the blade;
9 grades: full leaf morbidity is withered.
Drug effect calculating, toxicity index and co-toxicity coefficient (CTC) calculate, analytical method is the same.
Toxicity test the results are shown in Table 5 to table 8.
The serial proportioning of table 5 cyanogen frost azoles and ziram is to the Toxicity Determination result of tomato late blight
| Handle | ??EC 50(μg/mL) | ??ATI | ??TTI | Co-toxicity coefficient CTC |
| Cyanogen frost azoles | ??0.39 | ??100 | ??/ | ??/ |
| Ziram | ??58.35 | ??0.7 | ??/ | ??/ |
| Cyanogen frost azoles 30: ziram 1 | ??0.31 | ??125.8 | ??96.8 | ??130.0 |
| Cyanogen frost azoles 20: ziram 1 | ??0.25 | ??156.0 | ??95.3 | ??163.7 |
| Cyanogen frost azoles 10: ziram 1 | ??0.2 | ??195.0 | ??91.0 | ??214.4 |
| Cyanogen frost azoles 5: ziram 1 | ??0.18 | ??216.7 | ??83.4 | ??259.7 |
| Cyanogen frost azoles 1: ziram 1 | ??0.28 | ??139.3 | ??50.3 | ??276.7 |
| Cyanogen frost azoles 1: ziram 5 | ??0.74 | ??52.7 | ??17.2 | ??306.0 |
| Cyanogen frost azoles 1: ziram 10 | ??1.47 | ??26.5 | ??9.7 | ??273.6 |
| Cyanogen frost azoles 1: ziram 20 | ??3.07 | ??12.7 | ??5.4 | ??235.3 |
| Cyanogen frost azoles 1: ziram 30 | ??4.96 | ??7.9 | ??3.9 | ??203.0 |
| Cyanogen frost azoles 1: ziram 50 | ??8.69 | ??4.5 | ??2.6 | ??171.6 |
| Cyanogen frost azoles 1: ziram 80 | ??15.13 | ??2.6 | ??1.9 | ??136.0 |
Result of the test shows, cyanogen frost azoles and the composite control tomato late blight of ziram, and proportioning is 30: 1-1: in the time of between 80, co-toxicity coefficient all more than 130.0, has synergistic effect, and 10: 1-1: in the time of between 30, co-toxicity coefficient all is higher than 203.0, and synergistic effect is more obvious.
The serial proportioning of table 6 cyanogen frost azoles and zineb is to the Toxicity Determination result of tomato late blight
| Handle | ?EC 50(μg/mL) | ??ATI | ??TTI | Co-toxicity coefficient CTC |
| Cyanogen frost azoles | ??0.42 | ??100 | ??/ | ??/ |
| Zineb | ??88.35 | ??0.5 | ??/ | ??/ |
| Cyanogen frost azoles 30: zineb 1 | ??0.32 | ??131.3 | ??96.8 | ??135.6 |
| Cyanogen frost azoles 20: zineb 1 | ??0.28 | ??150.0 | ??95.3 | ??157.5 |
| Cyanogen frost azoles 10: zineb 1 | ??0.22 | ??190.9 | ??91.0 | ??209.9 |
| Cyanogen frost azoles 5: zineb 1 | ??0.19 | ??221.1 | ??83.4 | ??265.0 |
| Cyanogen frost azoles 1: zineb 1 | ??0.29 | ??144.8 | ??50.2 | ??288.3 |
| Cyanogen frost azoles 1: zineb 5 | ??0.76 | ??55.3 | ??17.1 | ??323.9 |
| Cyanogen frost azoles 1: zineb 10 | ??1.48 | ??28.4 | ??9.5 | ??298.0 |
| Cyanogen frost azoles 1: zineb 20 | ??3.47 | ??12.1 | ??5.2 | ??232.1 |
| Cyanogen frost azoles 1: zineb 30 | ??5.96 | ??7.0 | ??3.7 | ??191.2 |
| Cyanogen frost azoles 1: zineb 50 | ??11.42 | ??3.7 | ??2.4 | ??151.5 |
| Cyanogen frost azoles 1: zineb 80 | ??17.53 | ??2.4 | ??1.7 | ??140.6 |
Result of the test shows, cyanogen frost azoles and the composite control tomato late blight of zineb, and proportioning is 30: 1-1: in the time of between 80, co-toxicity coefficient all more than 135.6, has synergistic effect, and 10: 1-1: in the time of between 30, co-toxicity coefficient all is higher than 191.2, and synergistic effect is more obvious.
The serial proportioning of table 7 cyanogen frost azoles and ambam is to the Toxicity Determination result of tomato late blight
| Handle | ??EC 50(μg/mL) | ??ATI | ??TTI | Co-toxicity coefficient CTC |
| Cyanogen frost azoles | ??0.42 | ??100 | ??/ | ??/ |
| For gloomy amine | ??86.35 | ??0.5 | ??/ | ??/ |
| Cyanogen frost azoles 30: ambam 1 | ??0.3 | ??140.0 | ??96.8 | ??144.6 |
| Cyanogen frost azoles 20: ambam 1 | ??0.27 | ??155.6 | ??95.3 | ??163.3 |
| Cyanogen frost azoles 10: ambam 1 | ??0.21 | ??200.0 | ??91.0 | ??219.9 |
| Cyanogen frost azoles 5: ambam 1 | ??0.19 | ??221.1 | ??83.4 | ??265.0 |
| Cyanogen frost azoles 1: ambam 1 | ??0.29 | ??144.8 | ??50.2 | ??288.3 |
| Cyanogen frost azoles 1: ambam 5 | ??0.75 | ??56.0 | ??17.1 | ??328.0 |
| Cyanogen frost azoles 1: ambam 10 | ??1.48 | ??28.4 | ??9.5 | ??297.7 |
| Cyanogen frost azoles 1: ambam 20 | ??3.27 | ??12.8 | ??5.2 | ??245.8 |
| Cyanogen frost azoles 1: ambam 30 | ??5.56 | ??7.6 | ??3.7 | ??204.4 |
| Cyanogen frost azoles 1: ambam 50 | ??11.31 | ??3.7 | ??2.4 | ??152.3 |
| Cyanogen frost azoles 1: ambam 80 | ??17.43 | ??2.4 | ??1.7 | ??140.5 |
Result of the test shows, cyanogen frost azoles and the composite control tomato late blight of ambam, and proportioning is 30: 1-1: in the time of between 80, co-toxicity coefficient all more than 140.5, has synergistic effect, and 10: 1-1: in the time of between 30, co-toxicity coefficient all is higher than 204.4, and synergistic effect is more obvious.
The serial proportioning of table 8 cyanogen frost azoles and Carbatene is to the Toxicity Determination result of tomato late blight
| Handle | ??EC 50(μg/mL) | ??ATI | ??TTI | Co-toxicity coefficient CTC |
| Cyanogen frost azoles | ??0.44 | ??100 | ??/ | ??/ |
| Carbatene | ??90.35 | ??0.5 | ??/ | ??/ |
| Cyanogen frost azoles 30: Carbatene 1 | ??0.31 | ??141.9 | ??96.8 | ??146.6 |
| Cyanogen frost azoles 20: Carbatene 1 | ??0.28 | ??157.1 | ??95.3 | ??165.0 |
| Cyanogen frost azoles 10: Carbatene 1 | ??0.21 | ??209.5 | ??91.0 | ??230.4 |
| Cyanogen frost azoles 5: Carbatene 1 | ??0.19 | ??231.6 | ??83.4 | ??277.6 |
| Cyanogen frost azoles 1: Carbatene 1 | ??0.28 | ??157.1 | ??50.2 | ??312.8 |
| Cyanogen frost azoles 1: Carbatene 5 | ??0.69 | ??63.8 | ??17.1 | ??373.5 |
| Cyanogen frost azoles 1: Carbatene 10 | ??1.38 | ??31.9 | ??9.5 | ??334.4 |
| Cyanogen frost azoles 1: Carbatene 20 | ??3.27 | ??13.5 | ??5.2 | ??257.5 |
| Cyanogen frost azoles 1: Carbatene 30 | ??5.28 | ??8.3 | ??3.7 | ??225.4 |
| Cyanogen frost azoles 1: Carbatene 50 | ??11.31 | ??3.9 | ??2.4 | ??159.6 |
| Cyanogen frost azoles 1: Carbatene 80 | ??17.83 | ??2.5 | ??1.7 | ??143.8 |
Result of the test shows, cyanogen frost azoles and the composite control tomato late blight of Carbatene, and proportioning is 30: 1-1: in the time of between 80, co-toxicity coefficient all more than 143.8, has synergistic effect, and 10: 1-1: in the time of between 30, co-toxicity coefficient all is higher than 225.4, and synergistic effect is more obvious.
Above measurement result shows, the proportioning of a kind of composite control cucumber downy mildew and tomato late blight is 30 in cyanogen frost azoles (A) and tpn, tmtd, ziram, mancozeb, zineb, ambam, Carbatene, the Propineb (B): 1-1: in the time of between 80, has synergistic effect, 10: 1-1: in the time of between 30, co-toxicity coefficient is more than 191.2, and synergistic effect is more obvious.
Bactericidal composition of the present invention can be prepared into known method and be fit to wetting powder, suspending agent or the water dispersible granules that agricultural is used.Below describe with specific embodiment, percentage is mass percent in the prescription.A kind of in active component present specification middle finger cyanogen frost azoles (A) and tpn, tmtd, ziram, mancozeb, zineb, ambam, Carbatene and the Propineb (B), below repeat no more.
Embodiment 1:31% cyanogen frost azoles tpn wetting powder
The former medicine 30% of 93.5% cyanogen frost azoles
The former medicine 1% of 98% tpn
Lauryl sodium sulfate (wetting agent) 2%
Sodium lignin sulfonate (dispersant) 5%
Naphthalene sulfonate (dispersant) 3%
Kaolin (filler) complements to 100%.
Active component, various auxiliary agent and filler etc. are fully mixed in the ratio of prescription, after ultrafine crusher is pulverized, make 100 grams, 31% cyanogen frost azoles tpn wetting powder.
This embodiment is applied to prevent and treat cucumber downy mildew.31% cyanogen frost azoles tpn suspending agent is sprayed by 4000 times of (cyanogen frost azoles valid density is 75 μ g/ml, and tpn valid density is 2.5 μ g/ml) thin ups, and the control efficiency of 7 days and 15 days is respectively 89.8%, 88.2% behind the medicine.9% cyanogen frost azole suspending agent by 1000 times (the white azoles valid density of cyanogen is 90 μ g/ml) and 25% tpn wetting powder by 500 times (valid density is 500 μ g/ml), with using with quadrat method, the preventive effect of 7 days and 15 days is respectively 84.1%, 83.3% and 75.3%, 71.7% behind the medicine.Synergistic effect is obvious behind cyanogen frost azoles and the chlorothalonil compound, to the preventive effect of cucumber downy mildew significantly better than single agent.
Embodiment 2:10% cyanogen frost azoles tmtd suspending agent
The former medicine 5% of 93.5% cyanogen frost azoles
The former medicine 5% of 96% tmtd
Methyl naphthalene sulfonate formaldehyde condensate (wetting dispersing agent) 10%
Xanthans (thickener) 1%
Bentonite (carrier) 1%
Glycerine (antifreeze) 1%
Water complements to 100%.
The ratio of each component such as active component, wetting dispersing agent, thickener, carrier and water in prescription mixed, after grinding and/or high speed shear, obtain 10% cyanogen frost azoles tmtd suspending agent, 100 grams.
This embodiment is applied to prevent and treat peronophythora litchi.10% cyanogen frost azoles tmtd suspending agent is sprayed by 1000 times of (cyanogen frost azoles valid density is 50 μ g/ml, and tmtd valid density is 50 μ g/ml) thin ups, and the control efficiency of 7 days and 15 days is respectively 88.3%, 87.7% behind the medicine.15% cyanogen frost azole suspending agent by 2000 times (valid density is 75 μ g/ml) and 50% thiram wettable powder by 500 times (valid density is 1000 μ g/ml), with using with quadrat method, the preventive effect of 7 days and 15 days is respectively 84.9%, 83.2% and 85.4%, 81.6% behind the medicine.Cyanogen frost azoles is obvious with the composite synergistic effect afterwards of tmtd, to the preventive effect of peronophythora litchi significantly better than single agent.
Embodiment 3:81% cyanogen frost azoles mancozeb wettable powder
The former medicine 1% of 93.5% cyanogen frost azoles
The former medicine 80% of 96% mancozeb
Lauryl sodium sulfate (wetting agent) 2%
Sodium lignin sulfonate (dispersant) 5%
Naphthalene sulfonate (dispersant) 3%
Kaolin (filler) complements to 100%.
Active component, various auxiliary agent and filler etc. are fully mixed in the ratio of prescription, after ultrafine crusher is pulverized, make 40.5% cyanogen frost azoles mancozeb wettable powder, 100 grams and be used for field trial.
This embodiment is applied to downy mildew of lettuce.81% cyanogen frost azoles mancozeb is sprayed by 1000 times of (cyanogen frost azoles valid density is 10 μ g/ml, and mancozeb valid density is 800 μ g/ml) thin ups, and the control efficiency of 7 days and 15 days is respectively 84.1%, 82.3% behind the medicine.4% cyanogen frost azole suspending agent by 1000 times (valid density is 20 μ g/ml) and 80% mancozeb water dispersible granule by 800 times (valid density is 1000 μ g/ml), with using with quadrat method, the preventive effect of 7 days and 15 days is respectively 72.9%, 70.7% and 76.3%, 75.5% behind the medicine.Cyanogen frost azoles is obvious with the composite synergistic effect afterwards of mancozeb, to the preventive effect of downy mildew of lettuce significantly better than single agent.
Embodiment 4:90% cyanogen frost azoles Propineb water dispersible granules
The former medicine 30% of 93.5% cyanogen frost azoles
The former medicine 60% of 90% Propineb
Negel (dispersant) 0.5%
Sodium lignin sulfonate (dispersant 0.5%
Lauryl sodium sulfate (wetting agent) 0.5%
Kaolin (filler) is to 100%
Active component, dispersant, wetting agent and the filler ratio in prescription is mixed, become wetting powder, add a certain amount of water mixing extruding again and make material through comminution by gas stream.Obtain 100 grams, 90% cyanogen frost azoles Propineb water dispersible granules after the drying screening.
This embodiment is applied to prevent and treat tomato late blight.With 4000 times of 90% cyanogen frost azoles Propineb water dispersible granules (cyanogen frost azoles valid density is 75 μ g/ml, and Propineb valid density is 150 μ g/ml) thin ups spraying, field trial shows behind the medicine that the control efficiency of 7 days and 15 days is respectively 95.9%, 94.7%.20% cyanogen frost azoles water dispersible granules is by 2000 times (valid density is 100 μ g/ml), 80% Propineb water dispersible granules is by 1000 times (valid density is 800 μ g/ml), with using with quadrat method, the preventive effect of 7 days and 15 days is respectively 89.2%, 88.7% and 82.6%, 78.4% behind the medicine.Cyanogen frost azoles is obvious with the composite synergistic effect afterwards of Propineb, to the preventive effect of tomato late blight significantly better than single agent.
Embodiment 5:50% cyanogen frost azoles Zineb wettable powder
The former medicine 10% of 93.5% cyanogen frost azoles
The former medicine 40% of 96% zineb
Lauryl sodium sulfate (wetting agent) 2%
Sodium lignin sulfonate (dispersant) 5%
Naphthalene sulfonate (dispersant) 3%
Kaolin (filler) complements to 100%.
Active component, various auxiliary agent and filler etc. are fully mixed in the ratio of prescription, after ultrafine crusher is pulverized, make 100 grams, 50% cyanogen frost azoles Zineb wettable powder.
This embodiment is applied to the balsam pear cream mildew.Field trial is taked 50% cyanogen frost azoles zineb by 2500 times of (cyanogen frost azoles valid density is 40 μ g/ml, and zineb valid density is 160 μ g/ml) thin ups sprayings, and the control efficiency of 7 days and 15 days is respectively 94.6%, 92.4% behind the medicine.Check experiment be with 6% cyanogen frost azole suspending agent by 1000 times (valid density is 60 μ g/ml) and 80% water dispersion granules agent of dithane by 1000 times (valid density is 800 μ g/ml), with using with quadrat method, the preventive effect of 7 days and 15 days is respectively 85.9%, 84.7% and 84.3%, 80.5% behind the medicine.Cyanogen frost azoles is obvious with the composite synergistic effect afterwards of zineb, to the preventive effect of balsam pear cream mildew significantly better than single agent.
Embodiment 6:30% cyanogen frost azoles thioneb wettable powder
The former medicine 5% of 93.5% cyanogen frost azoles
The former medicine 25% of 85% Carbatene
Lauryl sodium sulfate (wetting agent) 2%
Sodium lignin sulfonate (dispersant) 5%
Naphthalene sulfonate (dispersant) 3%
Kaolin (filler) complements to 100%.
Active component, various auxiliary agent and filler etc. are fully mixed in the ratio of prescription, after ultrafine crusher is pulverized, make 100 grams, 30% cyanogen frost azoles thioneb wettable powder.
This embodiment is applied to the balsam pear cream mildew.Field trial is taked 30% cyanogen frost azoles Carbatene by 1000 times of (cyanogen frost azoles valid density is 50 μ g/ml, and Carbatene valid density is 250 μ g/ml) thin ups sprayings, and the control efficiency of 7 days and 15 days is respectively 94.6%, 92.4% behind the medicine.Check experiment be with 6% cyanogen frost azole suspending agent by 1000 times (valid density is 60 μ g/ml) and 40% Carbatene water dispersible granules by 1000 times (valid density is 400 μ g/ml), with using with quadrat method, the preventive effect of 7 days and 15 days is respectively 83.9%, 81.7% and 81.3%, 79.3% behind the medicine.Cyanogen frost azoles is obvious with the composite synergistic effect afterwards of Carbatene, to the preventive effect of balsam pear cream mildew significantly better than single agent.
Embodiment 7:30% cyanogen frost azoles ziram suspending agent
93.5% cyanogen frost azoles 5%
96% ziram 25%
Negel (wetting dispersing agent) 4%
Sodium lignin sulfonate (dispersant) 2%
Lauryl sodium sulfate (wetting agent) 5%
Kaolin (filler) is to 100%
The ratio of each component such as active component, wetting dispersing agent, thickener, carrier and water in prescription mixed, after grinding and/or high speed shear, obtain 30% cyanogen frost azoles ziram suspending agent, 100 grams and be used for field trial.
This embodiment is applied to prevent and treat downy mildew of garpe.30% cyanogen frost azoles ziram suspending agent is sprayed by 1000 times of (cyanogen frost azoles valid density is 50 μ g/ml, and ziram valid density is 250 μ g/ml) thin ups, and the control efficiency of 7 days and 15 days is respectively 89.5%, 88.2% behind the medicine.15% cyanogen frost azole suspending agent by 2000 times (valid density is 75 μ g/ml) and 80% ziram water dispersible granules by 1000 times (valid density is 800 μ g/ml), with using with quadrat method, the preventive effect of 7 days and 15 days is respectively 84.9%, 83.9% and 84.7%, 80.6% behind the medicine.Cyanogen frost azoles is obvious with the composite synergistic effect afterwards of ziram, to the preventive effect of downy mildew of garpe significantly better than single agent.
Embodiment 8:40% cyanogen frost azoles tpn wetting powder
The former medicine 10% of 93.5% cyanogen frost azoles
The former medicine 30% of 96% tpn
Lauryl sodium sulfate (wetting agent) 2%
Sodium lignin sulfonate (dispersant) 5%
Naphthalene sulfonate (dispersant) 3%
Kaolin (filler) complements to 100%.
Active component, various auxiliary agent and filler etc. are fully mixed in the ratio of prescription, after ultrafine crusher is pulverized, promptly get 100 grams, 40% cyanogen frost azoles tpn wetting powder.
This embodiment is applied to capsicum epidemic disease.40% cyanogen frost azoles tpn is sprayed by 2000 times of (cyanogen frost azoles valid density is 50 μ g/ml, and tpn valid density is 150 μ g/ml) thin ups, and the control efficiency of 7 days and 15 days is respectively 89.1%, 88.3% behind the medicine.8% cyanogen frost azole suspending agent by 1000 times (valid density is 80 μ g/ml) and 80% chlorothalonil water dispersible granule by 800 times (valid density is 1000 μ g/ml), with using with quadrat method, the preventive effect of 7 days and 15 days is respectively 82.6%, 81.5% and 81.5%, 80.2% behind the medicine.Synergistic effect is obvious behind cyanogen frost azoles and the chlorothalonil compound, to the preventive effect of capsicum epidemic disease significantly better than single agent.
Claims (7)
1, a kind of bactericidal composition; it is characterized in that: contain active ingredient cyanogen frost azoles (A) and another kind of protective fungicide (B) in the described bactericidal composition; B can be selected from tpn, tmtd, ziram, mancozeb, zineb, Propineb, ambam and the Carbatene any, and the mass ratio of A and B is 30: 1-1: 80.
2, according to claim 1, it is characterized in that: the mass ratio of effective constituents A and B is 10: 1-1: 30.
3, according to claim 1 or 2, it is characterized in that: the gross mass percentage composition of active ingredient in bactericidal composition is 10%-90%.
4, according to claim 3, it is characterized in that: the formulation of described bactericidal composition is wetting powder, suspending agent or water dispersible granules.
5, according to claim 1, it is characterized in that: described bactericidal composition is applied to prevent and treat crop pest.
6, the application of bactericidal composition according to claim 5 is characterized in that: described crop is flowers, paddy rice, wheat, fruit tree, cotton, rape, vegetables.
7, according to claim 5 or 6, it is characterized in that: described bactericidal composition is applied to prevent and treat the Oomycete disease.
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| CN200910161263A CN101658179A (en) | 2009-07-22 | 2009-07-22 | Complex bactericidal composition containing cyazofamid |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101743984A (en) * | 2010-01-22 | 2010-06-23 | 青岛奥迪斯生物科技有限公司 | Efficient bactericidal composite with cyazofamid and metiram |
| CN101773130A (en) * | 2010-01-22 | 2010-07-14 | 青岛奥迪斯生物科技有限公司 | Bactericidal composition containing cyazofamid and propineb |
| CN101700014B (en) * | 2009-11-30 | 2013-07-24 | 青岛星牌作物科学有限公司 | Germicide composition and application |
| CN103271037A (en) * | 2013-03-23 | 2013-09-04 | 内蒙古帅旗生物科技股份有限公司 | Pesticide composition for preventing and curing cucumber downy mildew |
| CN103598204A (en) * | 2013-11-14 | 2014-02-26 | 山东美罗福农业科技股份有限公司 | Bactericide composition and application thereof |
| CN104222092A (en) * | 2014-09-18 | 2014-12-24 | 中农立华生物科技股份有限公司 | Sterilization composition, preparation and application of preparation |
| CN104920401A (en) * | 2015-06-08 | 2015-09-23 | 柳州市天姿园艺有限公司 | Composition for controlling phytophthora root rot of dendrobium nobile lindl |
| CN104938507A (en) * | 2015-06-09 | 2015-09-30 | 柳州市天姿园艺有限公司 | Composition for preventing and controlling phytophthora root rot of vanda |
| CN111642503A (en) * | 2013-11-26 | 2020-09-11 | Upl 有限公司 | Method for controlling rust |
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2009
- 2009-07-22 CN CN200910161263A patent/CN101658179A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101700014B (en) * | 2009-11-30 | 2013-07-24 | 青岛星牌作物科学有限公司 | Germicide composition and application |
| CN101743984A (en) * | 2010-01-22 | 2010-06-23 | 青岛奥迪斯生物科技有限公司 | Efficient bactericidal composite with cyazofamid and metiram |
| CN101773130A (en) * | 2010-01-22 | 2010-07-14 | 青岛奥迪斯生物科技有限公司 | Bactericidal composition containing cyazofamid and propineb |
| CN103271037A (en) * | 2013-03-23 | 2013-09-04 | 内蒙古帅旗生物科技股份有限公司 | Pesticide composition for preventing and curing cucumber downy mildew |
| CN103598204A (en) * | 2013-11-14 | 2014-02-26 | 山东美罗福农业科技股份有限公司 | Bactericide composition and application thereof |
| CN111642503A (en) * | 2013-11-26 | 2020-09-11 | Upl 有限公司 | Method for controlling rust |
| CN104222092A (en) * | 2014-09-18 | 2014-12-24 | 中农立华生物科技股份有限公司 | Sterilization composition, preparation and application of preparation |
| CN104222092B (en) * | 2014-09-18 | 2016-04-20 | 中农立华生物科技股份有限公司 | A kind of bactericidal composition and preparation and application thereof |
| CN104920401A (en) * | 2015-06-08 | 2015-09-23 | 柳州市天姿园艺有限公司 | Composition for controlling phytophthora root rot of dendrobium nobile lindl |
| CN104938507A (en) * | 2015-06-09 | 2015-09-30 | 柳州市天姿园艺有限公司 | Composition for preventing and controlling phytophthora root rot of vanda |
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Application publication date: 20100303 |