CN104430375A - Fungicidal composition - Google Patents
Fungicidal composition Download PDFInfo
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- CN104430375A CN104430375A CN201410596910.0A CN201410596910A CN104430375A CN 104430375 A CN104430375 A CN 104430375A CN 201410596910 A CN201410596910 A CN 201410596910A CN 104430375 A CN104430375 A CN 104430375A
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- azoles alcohol
- fluorobenzene ether
- cucumber
- composition
- acid amides
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Abstract
The invention belongs to the technical field of pesticides, and relates to a fungicidal composition. The fungicidal composition is characterized in that active ingredients comprise hexaconazole and fluorophenylate amide. The composition can be prepared into a suspending agent, a water dispersible agent, and a suspoemulsion, the synergism is obvious, the production of the drug resistance is delayed while the dosage is reduced, the lasting period is prolonged, and the composition is environmentally friendly.
Description
Technical field
The invention belongs to technical field of pesticide, contain the bactericidal composition of own azoles alcohol and fluorobenzene ether acid amides specifically.
Background technology
Own azoles alcohol (Hexaconzole) is novel low toxicity, efficient, wide-spectrum bactericide.Belong to triazole bactericidal agent, sterol demethylation inhibitors, the biosynthesis of the cell membrane important composition composition ergosterol of destruction and prevention germ, causes cell membrane not formed, and makes germ dead.This composition has interior suction, protection and therapeutic activity.Show also there is good control efficiency to powdery mildew of cucumber, grape powdery mildew and black rot, the cercospora brown spot of peanut through field control effectiveness test result.This composition shows cucumber, grape through field efficacy experiment, has no poisoning and occurs.
Fluorobenzene ether acid amides is Central China Normal University's pyrazol acid amide compounds newly developed, has extraordinary effect to the powdery mildew that the crop such as cucumber, grape is common, and active ingredient is novel, non-resistant.
Powdery mildew of cucumber is one of important disease of dependent territory cucumber.All there is distribution various places, usually serious in the morbidity of cucumber growth intermediary and later stages, cause the production loss of cucumber.All the time, the main area of cucumber is reused in a large number due to the medicament preventing and treating powdery mildew, improves Disease Resistance, causes powdery mildew seriously to occur year after year.
Summary of the invention
The object of this invention is to provide a kind of there is synergistic effect and the bactericidal composition of safety and environmental protection for preventing and treating powdery mildew of cucumber, compared with existing pesticide control, realize improving drug effect, decreasing pollution, the object that reduces costs.Be specifically related to the bactericidal composition of own azoles alcohol and fluorobenzene ether acid amides.
Utilize above-mentioned bactericidal composition, be equipped with the known auxiliary agent of those skilled in that art, make formulation of the present invention with the known method of those skilled in that art, comprise suspending agent, water dispersible granules, suspension emulsion.
In above-mentioned bactericidal composition, the weight ratio of own azoles alcohol and fluorobenzene ether acid amides is 1:60-60:1.
Above-mentioned bactericidal composition has following characteristics: the 1. advanced environmental protection of formulation, and environmental pollution is little; 2. bactericidal action is strong, not easily develops immunity to drugs; 3. two kinds of compositions are composite, have synergistic effect; 4. active ingredient is advanced, non-resistant.
First applicant uses these two kinds of compositions to carry out indoor biometrics test, test method and result as follows:
First, after analyzing the action character of two kinds of active ingredients, the raw object surveyed is decided to be monofilament powdery mildew by us, and this bacterium can cause powdery mildew of cucumber.
The test method of indoor biometrics, with reference to NYT 1156.11-2008, adopts pot-culture method to measure medicament to the preventive and therapeutic effect of powdery mildew of cucumber.On the basis of preliminary experiment, from each medicament, design 5 concentration within the scope of 10%-90% are reached to germ mycelial growth inhibition rate, it is for subsequent use by the 95% former medicine of own azoles alcohol and the former medicine of 95% fluorobenzene ether acid amides with methyl alcohol to be first that solvent is made into the liquid of series concentration, then liquid is joined in 1% ratio in the PDA medium melting also cool to room temperature, after fully shaking up, pour in the culture dish (Φ 90mm) of sterilizing and make band medicine flat board, often process and repeat, to add the process of sterile water for blank for four times; With card punch (Φ 5mm) the picking cucumber powdery mildew's pathogen bacterium cake of sterilizing, mycelia faces down aseptic inoculation in the central authorities of band medicine flat board, be inverted in the interior cultivation of constant incubator of 25 DEG C, adopt right-angled intersection method to measure colony diameter after cultivating 6d, calculate the EC of each medicament to pathogen
50, and calculate toxicity index according to the following equation, compare virulence and the bacteriostasis of different agents.Former medicine used is tested in above-mentioned raw test and reagent is all bought from other producers.
The co-toxicity coefficient method representation that the co-toxicity of mixture preparation adopts Sun Yun abundant:
The theoretical toxicity index TTI=∑ of mixture preparation (percentage of this pharmaceutically active ingredient of the toxicity index ATI of certain medicine × in mixture).
Be synergistic effect when co-toxicity coefficient CTC is greater than 120, being antagonism when being less than 80, is addition time between 80-120.Indoor biometrics test data sees the following form:
The own azoles alcohol of table 1, fluorobenzene ether acid amides and different ratio thereof are to the measurement result of powdery mildew of cucumber co-toxicity coefficient
Analyze above-mentioned data, can obviously find out, when own azoles alcohol and fluorobenzene ether acid amides are composite in varing proportions, the co-toxicity coefficient (CTC) of formula is all greater than 137, the prevention and control capability of powdery mildew of cucumber is had to the synergistic effect of different proportion.
Tested by indoor biometrics, determine own azoles alcohol and fluorobenzene ether acid amides two kinds of active ingredients composite after, can have good synergistic effect, below by way of instantiation in order to further describe the present invention, but the present invention is absolutely not only only limitted to these embodiments following.In formula, percentage is all weight percentage, and the former medicine used and auxiliary agent are other producers and buy.
Formulation examples is as follows:
The own azoles alcohol fluorobenzene ether acid amides water dispersible granules of example one, 36.6%
The own azoles alcohol fluorobenzene ether amide suspending agents of example two, 15.5%
The own azoles alcohol fluorobenzene ether amide suspending agents of example three, 33%
The own azoles alcohol fluorobenzene ether amide suspending agents of example four, 18%
The own azoles alcohol fluorobenzene ether acid amides suspension emulsion of example five, 16%
The own azoles alcohol fluorobenzene ether amide suspending agents of example six, 30%
The own azoles alcohol fluorobenzene ether acid amides water dispersible granules of example seven, 22%
The own azoles alcohol fluorobenzene ether amide suspending agents of example eight, 31%
The own azoles alcohol fluorobenzene ether amide suspending agents of example nine, 30.5%
Select above example to carry out preventing and treating the field trial of powdery mildew of cucumber, determine to fill a prescription and prevent and treat the effect of powdery mildew of cucumber; Simultaneously by the Contrast on effect with own azoles alcohol and fluorobenzene ether acid amides single dose, verify composite after synergistic effect.Concrete test method is with reference to GB/T17980.30-2000.
The field control effectiveness test of powdery mildew of cucumber prevented and treated by 30% own azoles alcohol fluorobenzene ether amide suspending agents and other preparation, carries out comparative trial with 5% hexaconazole suspending agent and 24% fluorobenzene ether amide suspending agents single dose simultaneously.Test site is green house of vegetables area, Heze city of Shandong province, time is on June 14th, 2014, test each process four repetition, community randomized arrangement, each plot area is 8m2, adopts back-pack electric compression sprayer, dispenser was sunny calm for the same day, the planting habit of planting habit all with local of all communities is identical, records the synoptic data on the dispenser same day and a week thereafter, specific as follows:
Table 2 duration of test meteorological data
| Date | Weather | With or without special weather situation |
| 6-14 | 20-31 DEG C fine | Nothing |
| 6-15 | 20-31 DEG C fine | Nothing |
| 6-16 | 20-32 DEG C cloudy | Nothing |
| 6-17 | 20-32 DEG C cloudy | Nothing |
| 6-18 | 20-32 DEG C fine | Nothing |
| 6-19 | 20-32 DEG C fine | Nothing |
| 6-20 | 21-31 DEG C cloudy | Nothing |
| 6-21 | 21-32 DEG C cloudy | Nothing |
| 6-22 | 20-32 DEG C fine | Nothing |
| 6-23 | 21-32 DEG C fine | Nothing |
| 6-24 | 21-31 DEG C cloudy | Nothing |
| 6-25 | 21-32 DEG C of the moon | Nothing |
| 6-26 | 21-31 DEG C cloudy | Nothing |
| 6-27 | 22-32 DEG C of the moon | Nothing |
| 6-28 | 22-32 DEG C fine | Nothing |
Investigation method is: each community gets 4 investigation at random, and look into two strains at often, whole blade is investigated in every strain.Every sheet leaf accounts for leaf area percentage classification record by lesion area.Investigation in 7th day after dispenser, dispenser 2 times, investigates each community disease and refers to altogether, calculates preventive effect, and carries out the new multipole difference analysis of Deng Kenshi.
Blade grade scale:
0 grade: without scab;
1 grade: lesion area accounts for less than 5% of whole leaf area;
3 grades: lesion area accounts for 6% ~ 10% of whole leaf area;
5 grades: lesion area accounts for 11% ~ 20% of whole leaf area;
7 grades: lesion area accounts for 21% ~ 40% of whole leaf area;
9 grades: lesion area accounts for more than 40% of whole leaf area.
Table 3 30% own azoles alcohol fluorobenzene ether amide suspending agents and different agents are to the preventive effect of powdery mildew of cucumber
As can be seen from above-mentioned data, own azoles alcohol and fluorobenzene ether acid amides complex preparation after first time medicine the preventive effect of 7 days all more than 74%.And the preventive effect that 24% fluorobenzene ether amide suspending agents, 7 days preventive effects after medicine are only 49.88%, 5% hexaconazole suspending agent is 54.04%, compare fluorobenzene ether acid amides and own azoles alcohol single dose, complex preparation has good synergistic effect.And after last medicine 7 days, all complex preparations have all exceeded 80% to the preventive effect of powdery mildew of cucumber.Compared with after first time medicine 7 days, preventive effect is higher.Visible, complex preparation can improve drug effect, extends the lasting period, alleviates the amount of labour of peasant, have very high practicality.
Claims (2)
1. bactericidal composition, is characterized in that: active component is made up of own azoles alcohol and fluorobenzene ether acid amides, and the weight ratio of described own azoles alcohol and fluorobenzene ether acid amides is 1:60 ~ 60:1.
2. composition according to claim 1, is characterized in that: make suspending agent, water dispersible granules, suspension emulsion by active component and auxiliary material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410596910.0A CN104430375A (en) | 2014-10-29 | 2014-10-29 | Fungicidal composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410596910.0A CN104430375A (en) | 2014-10-29 | 2014-10-29 | Fungicidal composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104430375A true CN104430375A (en) | 2015-03-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410596910.0A Pending CN104430375A (en) | 2014-10-29 | 2014-10-29 | Fungicidal composition |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104886073A (en) * | 2015-05-21 | 2015-09-09 | 华中师范大学 | Fungicide composite, and preparation and application of fungicide composite |
| CN107006491A (en) * | 2016-01-28 | 2017-08-04 | 响水县智诚知识产权信息服务有限公司 | A kind of azoles of bacterium containing methylsulfonyl and the bactericidal composition of fluorobenzene ether amide |
| CN112772663A (en) * | 2019-11-04 | 2021-05-11 | 东莞市东阳光菌阳氢专利农药有限公司 | Composition containing flufenoxanil and penconazole, preparation and application thereof |
| CN114097795A (en) * | 2020-08-26 | 2022-03-01 | 山东省联合农药工业有限公司 | Bactericidal composition containing pyrazole amide compounds and triazole bactericide |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1226244A (en) * | 1996-07-24 | 1999-08-18 | 拜尔公司 | Carbanilides used as pesticides |
| JP2004189738A (en) * | 2002-11-29 | 2004-07-08 | Nippon Nohyaku Co Ltd | Substituted anilide derivative, its intermediate, agricultural horticultural chemical and usage of the same |
| CN101056858A (en) * | 2004-09-06 | 2007-10-17 | 巴斯福股份公司 | (hetero)cyclyl(thio) carboxylic acid anilides for controlling pathogenic fungi |
| CN101217873A (en) * | 2005-07-06 | 2008-07-09 | 巴斯福股份公司 | Fungicidal mixtures made from 1-methylpyrazol-4-ylcarboxanilides |
| WO2012065947A1 (en) * | 2010-11-15 | 2012-05-24 | Bayer Cropscience Ag | 5-halogenopyrazolecarboxamides |
-
2014
- 2014-10-29 CN CN201410596910.0A patent/CN104430375A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1226244A (en) * | 1996-07-24 | 1999-08-18 | 拜尔公司 | Carbanilides used as pesticides |
| JP2004189738A (en) * | 2002-11-29 | 2004-07-08 | Nippon Nohyaku Co Ltd | Substituted anilide derivative, its intermediate, agricultural horticultural chemical and usage of the same |
| CN101056858A (en) * | 2004-09-06 | 2007-10-17 | 巴斯福股份公司 | (hetero)cyclyl(thio) carboxylic acid anilides for controlling pathogenic fungi |
| CN101217873A (en) * | 2005-07-06 | 2008-07-09 | 巴斯福股份公司 | Fungicidal mixtures made from 1-methylpyrazol-4-ylcarboxanilides |
| WO2012065947A1 (en) * | 2010-11-15 | 2012-05-24 | Bayer Cropscience Ag | 5-halogenopyrazolecarboxamides |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104886073A (en) * | 2015-05-21 | 2015-09-09 | 华中师范大学 | Fungicide composite, and preparation and application of fungicide composite |
| CN107006491A (en) * | 2016-01-28 | 2017-08-04 | 响水县智诚知识产权信息服务有限公司 | A kind of azoles of bacterium containing methylsulfonyl and the bactericidal composition of fluorobenzene ether amide |
| CN112772663A (en) * | 2019-11-04 | 2021-05-11 | 东莞市东阳光菌阳氢专利农药有限公司 | Composition containing flufenoxanil and penconazole, preparation and application thereof |
| CN112772663B (en) * | 2019-11-04 | 2024-01-16 | 东莞市东阳光菌阳氢专利农药有限公司 | Composition containing fluoride phenylate amide and penconazole, preparation and application thereof |
| CN114097795A (en) * | 2020-08-26 | 2022-03-01 | 山东省联合农药工业有限公司 | Bactericidal composition containing pyrazole amide compounds and triazole bactericide |
| WO2022042605A1 (en) * | 2020-08-26 | 2022-03-03 | 山东省联合农药工业有限公司 | Bactericidal composition comprising pyrazole amide compound and triazole bactericide |
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Application publication date: 20150325 |