CN104396972A - Compound bactericide - Google Patents

Compound bactericide Download PDF

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Publication number
CN104396972A
CN104396972A CN201410579093.8A CN201410579093A CN104396972A CN 104396972 A CN104396972 A CN 104396972A CN 201410579093 A CN201410579093 A CN 201410579093A CN 104396972 A CN104396972 A CN 104396972A
Authority
CN
China
Prior art keywords
tricyclazole
acid amides
fluorobenzene ether
ether acid
dispersible granules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201410579093.8A
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Chinese (zh)
Inventor
杨会营
刘晓娇
吴勇
张�浩
田胜
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Yanhua Yongle Biotechnology Co Ltd
Original Assignee
Beijing Yanhua Yongle Biotechnology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Yanhua Yongle Biotechnology Co Ltd filed Critical Beijing Yanhua Yongle Biotechnology Co Ltd
Priority to CN201410579093.8A priority Critical patent/CN104396972A/en
Publication of CN104396972A publication Critical patent/CN104396972A/en
Pending legal-status Critical Current

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Abstract

Belonging to the technical field of pesticides, the invention relates to a compound bactericide, which is characterized by including fluorobenzene ether amide and tricyclazole as the active ingredients. The composition can be prepared into water dispersible granules, has an obvious synergistic effect, can delay drug resistance while reducing the dosage, prolongs the duration, and is friendly to the environment.

Description

A kind of composite bactericide
Technical field
The invention belongs to technical field of pesticide, contain the composition pesticide with synergistic effect of tricyclazole and fluorobenzene ether acid amides specifically.
Background technology
Tricyclazole (tricyclazole) has stronger interior absorption, can be absorbed by rice root cauline leaf rapidly, and is transported to each portion of rice strain, and generally the interior dose that absorbs of rice strain in 2 hours can reach saturated after spraying.Tricyclazole diseases prevention is based on preventive effect, and use at premorbid, effect is best.
Fluorobenzene ether acid amides is Central China Normal University's pyrazol acid amide compounds newly developed, has good preventive effect to the banded sclerotial blight of paddy rice and wheat, also has certain control efficiency to the epidemic disease of the crop such as cucumber, tomato and sigatoka simultaneously.
Rice sheath blight disease, also known as moire disease, is infected by Rhizoctonia solani Kuhn to fall ill, how falls ill under high temperature, super-humid conditions.Banded sclerotial blight is serious in the harm of south rice region, is one of Major Diseases in current Rice Production.This disease can make paddy rice not ear, and particle weight declines.
Due to the use lack of standardization of current agricultural chemicals, cause disease more and more stronger to the resistance of agricultural chemicals, cause Pesticide use amount more and more higher, cause the pollution of environment.Shown by our experiment and relevant report, combined use of pesticides can be good at the deficiency overcoming existing product, improves drug effect, reduces usage amount.
Summary of the invention
The object of this invention is to provide a kind of composite bactericide with synergistic effect, for the water prevention rice sheath blight, compared with existing pesticide control, realize the object improving drug effect.Be specifically related to tricyclazole and the composite composition pesticide of fluorobenzene ether acid amides.
Utilize above-mentioned composition pesticide, be equipped with the known auxiliary agent of those skilled in that art, make formulation of the present invention with the known method of those skilled in that art, formulation of the present invention is water dispersible granules.
In above-mentioned composite bactericide, the proportion of tricyclazole and fluorobenzene ether acid amides is 1:50-50:1.
Above-mentioned composite bactericide has following characteristics: 1. two kinds of active ingredients are composite, have good synergistic effect; 2. active ingredient is novel, with existing bactericide without cross resistance; 3. to crop safety; 4. bactericidal action is fast, and the lasting period is long.
First applicant uses these two kinds of compositions to carry out indoor biometrics test, test method and result as follows:
After the action character analyzing two kinds of active ingredients, the raw object surveyed is decided to be thanatephorus cucumeris(frank) donk (Thanatephoruscucumeris) by us, this Pseudomonas Basidiomycotina fungi, sclerotium is dark brown, bacterium colony is light brown to taupe mildew, and this bacterium can cause the banded sclerotial blight of paddy rice.
The test method of indoor biometrics: reference standard NY/T1156.6-2006, adopts growth rate method to measure medicament to the inhibitory action of rice sheath blight disease pathogen mycelial growth.On the basis of preliminary experiment, from each medicament, design 5 concentration within the scope of 10%-90% are reached to germ mycelial growth inhibition rate, it is for subsequent use by 96% Mensurating Tricyclazole Technical and the former medicine of 95% fluorobenzene ether acid amides with acetone to be first that solvent is made into the liquid of series concentration, then liquid is joined in 1% ratio in the PDA medium melting also cool to room temperature, after fully shaking up, pour in the culture dish (Φ 90mm) of sterilizing and make band medicine flat board, often process and repeat, to add the process of sterile water for blank for four times; With card punch (Φ 5mm) the picking Rhizoctonia solani Kuhn bacterium cake of sterilizing, mycelia faces down aseptic inoculation in the central authorities of band medicine flat board, be inverted in the interior cultivation of constant incubator of 25 DEG C, adopt right-angled intersection method to measure colony diameter after cultivating 6d, calculate the EC of each medicament to pathogen 50, and calculate toxicity index according to the following equation, compare virulence and the bacteriostasis of different agents.Former medicine used is tested in above-mentioned raw test and reagent is all bought from other producers.
The co-toxicity coefficient method representation that the co-toxicity of mixture preparation adopts Sun Yun abundant:
The theoretical toxicity index TTI=∑ of mixture preparation (percentage of this pharmaceutically active ingredient of the toxicity index ATI of certain medicine × in mixture).
Be synergistic effect when co-toxicity coefficient CTC is greater than 120, being antagonism when being less than 80, is addition time between 80-120.
Table 1 tricyclazole and fluorobenzene ether acid amides and different ratio thereof are to the measurement result of rice sheath blight disease co-toxicity coefficient
Shown by above-mentioned data, when tricyclazole and fluorobenzene ether acid amides are composite in varing proportions, the co-toxicity coefficient (CTC) of formula is all greater than 120, the prevention and control capability of rice sheath blight disease is had to the synergistic effect of different proportion.
Tested by indoor biometrics, determine tricyclazole and fluorobenzene ether acid amides two kinds of active ingredients composite after, can have good synergistic effect, below by way of instantiation in order to further describe the present invention, but the present invention is absolutely not only only limitted to these embodiments following.In formula, percentage is all weight percentage, and the former medicine used and auxiliary agent are other producers and buy.
Formulation examples is as follows:
Example one, 35.7% tricyclazole fluorobenzene ether acid amides water dispersible granules
Example two, 51% tricyclazole fluorobenzene ether acid amides water dispersible granules
Example three, 31% tricyclazole fluorobenzene ether acid amides water dispersible granules
Example four, 15.5% tricyclazole fluorobenzene ether acid amides water dispersible granules
Example five, 22% tricyclazole fluorobenzene ether acid amides water dispersible granules
Example six, 33% tricyclazole fluorobenzene ether acid amides water dispersible granules
Example seven, 18% tricyclazole fluorobenzene ether acid amides water dispersible granules
Example eight, 12% tricyclazole fluorobenzene ether acid amides water dispersible granules
Example nine, 10% tricyclazole fluorobenzene ether acid amides water dispersible granules
Example ten, 30% tricyclazole fluorobenzene ether acid amides water dispersible granules
Select above example to carry out the field trial of the water prevention rice sheath blight, simultaneously by the Contrast on effect with tricyclazole and fluorobenzene ether acid amides single dose, verify composite after synergistic effect.Test site is At Jiujiang Region, Jiangxi Province, and the time is on July 7th, 2013, and test each process three repetition, community randomized arrangement, each plot area is 80m 2, adopt back-pack electric compression sprayer, dispenser was sunny calm for the same day, and the planting habit of planting habit all with local of all communities is identical, records the synoptic data on the dispenser same day and a week thereafter, specific as follows:
Table 2 duration of test meteorological data
Investigation method is with reference to GB/T 17980.34-2000, each community diagonal 5 sampling, often some sampling 2-3 strain, investigate fixed 2 points of whole blade each community diagonal, often fixed 25 clumps of paddy rice of straight ahead, fixed point investigation in the 7th day, 21 days after dispenser, investigate each community disease to refer to, calculate preventive effect, and carry out the new multipole difference analysis of Deng Kenshi, calculate according to following grade scale:
0 grade: without scab;
1 grade: lesion area accounts for less than 5% of whole leaf area;
3 grades: lesion area accounts for 6% ~ 10% of whole leaf area;
5 grades: lesion area accounts for 11% ~ 25% of whole leaf area;
7 grades: lesion area accounts for 26% ~ 50% of whole leaf area;
9 grades: lesion area accounts for more than 51% of whole leaf area, stem stalk there is scab.
Computing formula is as follows:
Table 3 30% tricyclazole fluorobenzene ether acid amides water dispersible granules and different agents are to the preventive effect of rice sheath blight disease
Analyze above-mentioned data to draw, tricyclazole and fluorobenzene ether acid amides composite after, after medicine, the preventive effect of 7 days is all more than 70%, and tricyclazole single dose 7 days preventive effects after medicine are 43.50%, the preventive effect of fluorobenzene ether acid amides single dose is 36.67%, after visible two kinds of active ingredients are composite, has good synergistic effect.And after medicine 21 days, the preventive effect of all complex preparations to rice sheath blight disease to be better than after medicine 7 days, and visible composite rear preparation extended the lasting period of rice sheath blight disease controlling, and control efficiency is more lasting.

Claims (2)

1. a composite bactericide, is characterized in that: active component is made up of tricyclazole and fluorobenzene ether acid amides, and the weight ratio of described tricyclazole and fluorobenzene ether acid amides is 1:50 ~ 50:1.
2. composite bactericide according to claim 1, is characterized in that: make water dispersible granules by active component and auxiliary material.
CN201410579093.8A 2014-10-25 2014-10-25 Compound bactericide Pending CN104396972A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201410579093.8A CN104396972A (en) 2014-10-25 2014-10-25 Compound bactericide

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Application Number Priority Date Filing Date Title
CN201410579093.8A CN104396972A (en) 2014-10-25 2014-10-25 Compound bactericide

Publications (1)

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CN104396972A true CN104396972A (en) 2015-03-11

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104886073A (en) * 2015-05-21 2015-09-09 华中师范大学 Fungicide composite, and preparation and application of fungicide composite
CN109418270A (en) * 2017-09-01 2019-03-05 浙江省化工研究院有限公司 A kind of bactericidal composition of fluorine-containing phenylate amide

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1226244A (en) * 1996-07-24 1999-08-18 拜尔公司 Carbanilides used as pesticides
CN101056858A (en) * 2004-09-06 2007-10-17 巴斯福股份公司 (hetero)cyclyl(thio) carboxylic acid anilides for controlling pathogenic fungi
CN101790986A (en) * 2010-04-16 2010-08-04 陕西美邦农药有限公司 Fungicide composite containing tricyclazole and hexaconazole
CN102057921A (en) * 2010-12-14 2011-05-18 江苏省绿盾植保农药实验有限公司 Fungicide containing tricyclazole and kasugamycin

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1226244A (en) * 1996-07-24 1999-08-18 拜尔公司 Carbanilides used as pesticides
CN101056858A (en) * 2004-09-06 2007-10-17 巴斯福股份公司 (hetero)cyclyl(thio) carboxylic acid anilides for controlling pathogenic fungi
CN101790986A (en) * 2010-04-16 2010-08-04 陕西美邦农药有限公司 Fungicide composite containing tricyclazole and hexaconazole
CN102057921A (en) * 2010-12-14 2011-05-18 江苏省绿盾植保农药实验有限公司 Fungicide containing tricyclazole and kasugamycin

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104886073A (en) * 2015-05-21 2015-09-09 华中师范大学 Fungicide composite, and preparation and application of fungicide composite
CN109418270A (en) * 2017-09-01 2019-03-05 浙江省化工研究院有限公司 A kind of bactericidal composition of fluorine-containing phenylate amide

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Application publication date: 20150311