CN104381268A - Compound bactericide - Google Patents
Compound bactericide Download PDFInfo
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- CN104381268A CN104381268A CN201410779113.6A CN201410779113A CN104381268A CN 104381268 A CN104381268 A CN 104381268A CN 201410779113 A CN201410779113 A CN 201410779113A CN 104381268 A CN104381268 A CN 104381268A
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- triazolone
- acid amides
- ether acid
- fluorobenzene ether
- dispersible granules
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Abstract
The invention belongs to the technical field of pesticides and relates to a compound bactericide. The compound bactericide is characterized in that active ingredients comprise fluorobenzene ether amide and triadimefon. The compound bactericide can be prepared into water dispersible granules, has remarkable synergism, prolongs the duration of efficacy and is friendly to the environment.
Description
Technical field
The invention belongs to technical field of pesticide, contain the composite bactericide with synergistic effect of triazolone and fluorobenzene ether acid amides specifically.
Background technology
The triazole bactericidal agent that triazolone (triadimefon) is a kind of efficient, low toxicity, low-residual, the lasting period is long, interior absorption is strong.After being absorbed by each several part of plant, can conduct in plant corpus.To rust and powdery mildew, there is prevention, root out, the effect such as treatment.As all effective in Helminthosporium carbonum, wheat class moire disease, wheat leaf blight, pineapple black rot, maize head smut etc. to the disease of various crop.Triazolone sterilization mainly suppresses the biosynthesis of thalline ergosterol, thus suppresses or disturb growth, the growth of mycelia and the formation of spore of thalline attachment spore and haustorium.Triazolone is very strong to some germ activity in live body, but in vitro poor effect.Strong to spore to the specific activity of mycelia.
Fluorobenzene ether acid amides is Central China Normal University's pyrazol acid amide compounds newly developed, has good preventive effect to the banded sclerotial blight of paddy rice and wheat, also has certain control efficiency to the epidemic disease of the crop such as cucumber, tomato and sigatoka simultaneously.
Rice sheath blight disease is infected by Rhizoctonia solani Kuhn to fall ill, and how to fall ill under high temperature, super-humid conditions.This disease can make paddy rice not ear, and particle weight declines.Visible banded sclerotial blight is serious in the harm of south rice region, is one of Major Diseases in current Rice Production.
Due to the use lack of standardization of current agricultural chemicals, cause disease more and more stronger to the resistance of agricultural chemicals, cause Pesticide use amount more and more higher, cause the pollution of environment.Shown by our experiment and relevant report, combined use of pesticides can be good at the deficiency overcoming existing product, improves drug effect, reduces usage amount.
Summary of the invention
The object of this invention is to provide a kind of composite bactericide with synergistic effect, for the water prevention rice sheath blight, compared with existing pesticide control, realize the object improving drug effect.Be specifically related to triazolone and the composite composite bactericide of fluorobenzene ether acid amides.
Utilize above-mentioned composite bactericide, be equipped with the known auxiliary agent of those skilled in that art, make formulation of the present invention with the known method of those skilled in that art, formulation of the present invention is water dispersible granules.
In above-mentioned composite bactericide, the weight ratio of triazolone and fluorobenzene ether acid amides is 1:50-50:1.
Above-mentioned composite bactericide has following characteristics: 1, use complex preparation, synergistic effect is obvious; 2, active ingredient and existing bactericide are without cross resistance, and effect is unique; 3, to rice safety, environmentally friendly; 4, bactericidal action is fast, and the lasting period is long; 5, formulation can be good at playing drug effect.
In order to verify two kinds of active ingredients composite after synergistic effect, first applicant uses these two kinds of compositions to carry out indoor biometrics test, according to the mode of action of active ingredient, the raw object surveyed is decided to be thanatephorus cucumeris(frank) donk (Thanatephorus cucumeris) by us, this Pseudomonas Basidiomycotina fungi, sclerotium is dark brown, and bacterium colony is light brown to taupe mildew, can cause the banded sclerotial blight of paddy rice.
The test method of indoor biometrics: reference standard NY/T1156.6-2006, adopts growth rate method to measure medicament to the inhibitory action of rice sheath blight disease pathogen mycelial growth.On the basis of preliminary experiment, from each medicament, design 5 concentration within the scope of 10%-90% are reached to germ mycelial growth inhibition rate, it is for subsequent use by the former medicine of 96% triazolone and the former medicine of 95% fluorobenzene ether acid amides with acetone to be first that solvent is made into the liquid of series concentration, then liquid is joined in 1% ratio in the PDA medium melting also cool to room temperature, after fully shaking up, pour in the culture dish (Φ 90mm) of sterilizing and make band medicine flat board, often process and repeat, to add the process of sterile water for blank for four times; With card punch (Φ 5mm) the picking Rhizoctonia solani Kuhn bacterium cake of sterilizing, mycelia faces down aseptic inoculation in the central authorities of band medicine flat board, be inverted in the interior cultivation of constant incubator of 25 DEG C, adopt right-angled intersection method to measure colony diameter after cultivating 6d, calculate the EC of each medicament to pathogen
50, and calculate toxicity index according to the following equation, compare virulence and the bacteriostasis of different agents.Former medicine used is tested in above-mentioned raw test and reagent is all bought from other producers.
The co-toxicity coefficient method representation that the co-toxicity of mixture preparation adopts Sun Yun abundant:
The theoretical toxicity index TTI=∑ of mixture preparation (percentage of this pharmaceutically active ingredient of the toxicity index ATI of certain medicine × in mixture).
Be synergistic effect when co-toxicity coefficient CTC is greater than 120, being antagonism when being less than 80, is addition time between 80-120.
Indoor biometrics test data sees the following form:
Table 1 triazolone and fluorobenzene ether acid amides and different ratio thereof are to the measurement result of rice sheath blight disease co-toxicity coefficient
Shown by above-mentioned data, when triazolone and fluorobenzene ether acid amides are composite in varing proportions, the co-toxicity coefficient (CTC) of formula is all greater than 120, the control efficiency of rice sheath blight disease is had to the raising of different proportion compared with single component.
Tested by indoor biometrics, determine triazolone and fluorobenzene ether acid amides two kinds of active ingredients composite after, can have good synergistic effect, below by way of instantiation in order to further describe the present invention, but the present invention is absolutely not only only limitted to these embodiments following.In formula, percentage is all weight percentage, and the former medicine used and auxiliary agent are other producers and buy.
Formulation examples is as follows:
Example one, 25.5% triazolone fluorobenzene ether acid amides water dispersible granules
Example two, 51% triazolone fluorobenzene ether acid amides water dispersible granules
Example three, 26% triazolone fluorobenzene ether acid amides water dispersible granules
Example four, 13% triazolone fluorobenzene ether acid amides water dispersible granules
Example five, 32% triazolone fluorobenzene ether acid amides water dispersible granules
Example six, 16% triazolone fluorobenzene ether acid amides water dispersible granules
Example seven, 36% triazolone fluorobenzene ether acid amides water dispersible granules
Example eight, 9% triazolone fluorobenzene ether acid amides water dispersible granules
Example nine, 50% triazolone fluorobenzene ether acid amides water dispersible granules
Example ten, 36% triazolone fluorobenzene ether acid amides water dispersible granules
Select above example to carry out the field trial of the water prevention rice sheath blight, simultaneously by the Contrast on effect with triazolone and fluorobenzene ether acid amides single dose, verify composite after synergistic effect.Test site is Anqing Area, Anhui Province, and the time is on June 3rd, 2014, and test each process three repetition, community randomized arrangement, each plot area is 85m
2, adopt back-pack electric compression sprayer, dispenser was sunny calm for the same day, and the planting habit of planting habit all with local of all communities is identical, records the synoptic data on the dispenser same day and a week thereafter, specific as follows:
Table 2 duration of test meteorological data
Investigation method is with reference to GB/T 17980.34-2000, each community diagonal 5 sampling, often some sampling 2-3 strain, investigate fixed 2 points of whole blade each community diagonal, often fixed 25 clumps of paddy rice of straight ahead, fixed point investigation in the 7th day, 21 days after dispenser, investigate each community disease to refer to, calculate preventive effect, and carry out the new multipole difference analysis of Deng Kenshi, calculate according to following grade scale:
0 grade: complete stool is anosis;
1 grade: quaterfoil and following leaf sheath, blade morbidity (taking sword-like leave as first leaf);
3 grades: Three-blade and following leaf sheath thereof, blade morbidity;
5 grades: second blade and following leaf sheath thereof, blade morbidity;
7 grades: sword-like leave blade and following leaf sheath thereof, blade morbidity;
9 grades: complete stool falls ill, withered ahead of time.
Computing formula is as follows:
Table 350% triazolone fluorobenzene ether acid amides water dispersible granules and different agents are to the preventive effect of rice sheath blight disease
Analyze above-mentioned data to draw, triazolone and fluorobenzene ether acid amides composite after after medicine, 7 days preventive effects are all more than 72%, and triazolone single dose 7 days preventive effects after medicine are 43.50%, and the preventive effect of fluorobenzene ether acid amides single dose is 40.09%, visible, two kinds of active ingredient is composite good synergistic effect.And after medicine 21 days, all complex preparations to be all better than after medicine 7 days to the preventive effect of rice sheath blight disease, and complex preparation can well improve drug effect, extends the lasting period, alleviates the amount of labour of peasant, has very high practicality.
Claims (2)
1. a composite bactericide, is characterized in that: active component is made up of triazolone and fluorobenzene ether acid amides, and the weight ratio of described triazolone and fluorobenzene ether acid amides is 1:50 ~ 50:1.
2. composite bactericide according to claim 1, is characterized in that: make water dispersible granules by active component and auxiliary material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410779113.6A CN104381268A (en) | 2014-12-15 | 2014-12-15 | Compound bactericide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410779113.6A CN104381268A (en) | 2014-12-15 | 2014-12-15 | Compound bactericide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104381268A true CN104381268A (en) | 2015-03-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410779113.6A Pending CN104381268A (en) | 2014-12-15 | 2014-12-15 | Compound bactericide |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104886079A (en) * | 2015-05-28 | 2015-09-09 | 西华大学 | Application of 1,2,3-thiadiazole-5-formamidine heterocyclic compound as acaricide |
| CN104886073A (en) * | 2015-05-21 | 2015-09-09 | 华中师范大学 | Fungicide composite, and preparation and application of fungicide composite |
| CN106614722A (en) * | 2016-12-29 | 2017-05-10 | 成都格瑞赛斯科技有限公司 | Chloramine phosphorus-containing insecticidal and bactericidal composition for preventing and treating rice diseases and pests |
| CN107006483A (en) * | 2017-04-28 | 2017-08-04 | 佛山市普尔玛农化有限公司 | A kind of synergetic pesticide composition containing prothioconazoles |
| CN107006491A (en) * | 2016-01-28 | 2017-08-04 | 响水县智诚知识产权信息服务有限公司 | A kind of azoles of bacterium containing methylsulfonyl and the bactericidal composition of fluorobenzene ether amide |
| CN112772663A (en) * | 2019-11-04 | 2021-05-11 | 东莞市东阳光菌阳氢专利农药有限公司 | Composition containing flufenoxanil and penconazole, preparation and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004189738A (en) * | 2002-11-29 | 2004-07-08 | Nippon Nohyaku Co Ltd | Substituted anilide derivative, its intermediate, agricultural horticultural chemical and usage of the same |
| CN101056858A (en) * | 2004-09-06 | 2007-10-17 | 巴斯福股份公司 | (hetero)cyclyl(thio) carboxylic acid anilides for controlling pathogenic fungi |
| CN103391925A (en) * | 2010-11-15 | 2013-11-13 | 拜耳知识产权有限责任公司 | 5-halogenopyrazolecarboxamides |
-
2014
- 2014-12-15 CN CN201410779113.6A patent/CN104381268A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004189738A (en) * | 2002-11-29 | 2004-07-08 | Nippon Nohyaku Co Ltd | Substituted anilide derivative, its intermediate, agricultural horticultural chemical and usage of the same |
| CN101056858A (en) * | 2004-09-06 | 2007-10-17 | 巴斯福股份公司 | (hetero)cyclyl(thio) carboxylic acid anilides for controlling pathogenic fungi |
| CN103391925A (en) * | 2010-11-15 | 2013-11-13 | 拜耳知识产权有限责任公司 | 5-halogenopyrazolecarboxamides |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104886073A (en) * | 2015-05-21 | 2015-09-09 | 华中师范大学 | Fungicide composite, and preparation and application of fungicide composite |
| CN104886079A (en) * | 2015-05-28 | 2015-09-09 | 西华大学 | Application of 1,2,3-thiadiazole-5-formamidine heterocyclic compound as acaricide |
| CN107006491A (en) * | 2016-01-28 | 2017-08-04 | 响水县智诚知识产权信息服务有限公司 | A kind of azoles of bacterium containing methylsulfonyl and the bactericidal composition of fluorobenzene ether amide |
| CN106614722A (en) * | 2016-12-29 | 2017-05-10 | 成都格瑞赛斯科技有限公司 | Chloramine phosphorus-containing insecticidal and bactericidal composition for preventing and treating rice diseases and pests |
| CN107006483A (en) * | 2017-04-28 | 2017-08-04 | 佛山市普尔玛农化有限公司 | A kind of synergetic pesticide composition containing prothioconazoles |
| CN112772663A (en) * | 2019-11-04 | 2021-05-11 | 东莞市东阳光菌阳氢专利农药有限公司 | Composition containing flufenoxanil and penconazole, preparation and application thereof |
| CN112772663B (en) * | 2019-11-04 | 2024-01-16 | 东莞市东阳光菌阳氢专利农药有限公司 | Composition containing fluoride phenylate amide and penconazole, preparation and application thereof |
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Application publication date: 20150304 |