CN103300024A - Sterilization composition containing tetramycin - Google Patents
Sterilization composition containing tetramycin Download PDFInfo
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- CN103300024A CN103300024A CN201310244974XA CN201310244974A CN103300024A CN 103300024 A CN103300024 A CN 103300024A CN 201310244974X A CN201310244974X A CN 201310244974XA CN 201310244974 A CN201310244974 A CN 201310244974A CN 103300024 A CN103300024 A CN 103300024A
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- tetramycin
- thifluzamide
- sterilization composition
- rice
- disease
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Abstract
The invention belongs to the technical field of pesticides and relates to a sterilization composition containing tetramycin. The sterilization composition is characterized in that the active ingredients comprise tetramycin and thifluzamide, wherein the weight ratio of tetramycin to thifluzamide (1:100)-(50:1). The composition can be prepared into a suspension and an aqueous solution. The sterilization composition is mainly used for preventing and treating the rice sheath blight disease, has the obvious synergistic effect and is safe to rice.
Description
Technical field
The invention belongs to technical field of pesticide, contain the bactericidal composition of tetramycin and thifluzamide specifically.
Background technology
Tetramycin (Tetramycin) claim tetramycin again, is by a strain that separates in the soil sample of Wuzhou, the Guangxi stimulation metabolite of streptomyces hygroscopicus Wuzhou subspecies (Streptomyces ahygroscopicn wuzhouensisn subsp.) not.This product fungicidal spectrum is wide, and three main kind of 26 kinds of known disease funguses such as mastigomycetes, sac fungi and Deuteromycotina fungi are all had extremely strong killing action.Be suitable for the control of the multiple fungal disease of various crops.This composition can obviously promote the callus healing simultaneously, promotes flourishing, the aging root system recovery of weak shoot root system, improves the crop disease-resistant ability and optimizes crop quality.
Thifluzamide (thifluzamide) belongs to the thiazole amide bactericide, has strong interior conductivity and the long lasting effect of inhaling.Thifluzamide is the succinate dehydrogenase inhibitor, because fluorine-containing, its its competitiveness in biochemical pathway is very strong, in case be combined with regard to difficult recovery with substrate or enzyme.Thifluzamide all has activity to pathomycetes such as Rhizoctonia, Puccinia, Ustilago, Tilletia, corticium, nuclear cavity Pseudomonas, especially the fungus-caused disease of Basidiomycetes such as banded sclerotial blight, damping off etc. is had special efficacy.Its main mechanism of action is to suppress succinic acid dehydrogenase in the germ tricarbonic acid cycle, causes thalline death.
Rice sheath blight disease (Rhizoctorzia solani) claims moire disease, popular name to spend sufficient stalk, mashed pin pest, features spot again.Be to infect and fall ill by Rhizoctonia solani Kuhn, how under high temperature, super-humid conditions, fall ill.Banded sclerotial blight is serious in the harm of south rice zone, is one of main disease on the current Rice Production.This disease can make paddy rice not ear, and particle weight descends, and has a strong impact on rice yield.
The bactericide product category is a lot of at present; but how lack of standardizationly use; kind and the consumption of bactericide are arbitrarily abused through regular meeting; make that the pesticide resistance of pathogen is more and more stronger; and draw according to our field control effectiveness test experience; two kinds of active ingredient is composite to can be good at alleviating pesticide resistance, and two kinds of active ingredients use with synergistic effect can also be arranged, and alleviates peasant's labour cost simultaneously.
Summary of the invention
The purpose of this invention is to provide a kind of bactericidal composition with synergistic effect, realize improving drug effect, reduce the purpose of polluting, reducing labour cost.This bactericidal composition contains tetramycin and two kinds of active ingredients of thifluzamide.
Utilize bactericidal composition of the present invention, be equipped with the known auxiliary agent of those skilled in that art, make formulation of the present invention with those skilled in that art's known method, comprise aqua and suspending agent.
In the above-mentioned bactericidal composition, the weight ratio of tetramycin and thifluzamide is 1:100~50:1.
Above-mentioned bactericidal composition has following characteristics: 1. composition novelty, and pesticide resistance is low; 2. organic principle is not added in formulation environmental protection; 3. two kinds of compositions are composite, and synergistic effect is remarkable; 4. twenty percent does not have cross resistance between dividing; 5. delay the generation of active ingredient resistance, reduce peasant's labour cost.
Embodiment
For determining tetramycin and two kinds of composite synergistic effects of active ingredient of thifluzamide, the applicant at first uses these two kinds of compositions to carry out the indoor biometrics test, and test method and result are as follows:
After at first having analyzed the effect characteristics of two kinds of active ingredients, we will give birth to the object of surveying control and be decided to be rice sheath blight disease, these sick pathogenic bacteria are thanatephorus cucumeris(frank) donk (Thanatephorus cucumeris), this Pseudomonas Basidiomycotina fungi, sclerotium is dark brown, and it is light brown to the taupe mildew that bacterium colony is.
The test method of indoor biometrics: adopt growth rate method to measure medicament to the inhibitory action of rice sheath blight disease mycelia growth.On the basis of preliminary experiment, from each medicament the germ mycelial growth inhibition rate is reached 5 concentration of design in 20%~90% scope, it is standby earlier with the former medicine of 95% tetramycin and the former medicinal methyl alcohol of 95% thifluzamide to be that solvent is made into the soup of series concentration, then with soup in 1% ratio join melt and the PDA medium of cool to room temperature in, after fully shaking up, pour into and make band medicine flat board in the culture dish (Φ 90mm) of sterilization, every processing repeats for four times, to add the blank that is treated to of sterile water; Card punch (Φ 5mm) picking Rhizoctonia solani Kuhn bacterium cake with sterilization, mycelia faces down aseptic inoculation in the central authorities of band medicine flat board, be inverted in 25 ℃ interior cultivation of constant incubator, adopt the right-angled intersection method to measure colony diameter after cultivating 6d, calculate each medicament to the EC50 of pathogen, and calculate toxicity index, the virulence of more different medicaments and bacteriostasis according to the following equation.Used former medicine is tested in above-mentioned living test and reagent is all bought from other producers.
The co-toxicity of mixture preparation adopts the abundant co-toxicity coefficient method representation of Sun Yun:
The theoretical toxicity index TTI=∑ of mixture preparation (the toxicity index ATI of certain medicine * percentage of this pharmaceutically active ingredient in mixture).
Co-toxicity coefficient CTC was synergistic effect greater than 120 o'clock, less than 80 o'clock be antagonism, be addition in the time of between 80~120.
The indoor biometrics test data sees the following form:
Table 1 tetramycin, thifluzamide and different proportioning are to the measurement result of rice sheath blight disease co-toxicity coefficient
By above-mentioned data as can be seen, when tetramycin and thifluzamide are composite in varing proportions, the co-toxicity coefficient (CTC) of prescription is all greater than 120, prevention and control capability to rice sheath blight disease has obvious synergistic effect, and wherein the synergistic effect between 1:5~5:1 of tetramycin and thifluzamide is the most remarkable.
By indoor biometrics verification experimental verification tetramycin and two kinds of active ingredients of thifluzamide are composite good synergistic effect arranged, below by instantiation in order to further describing the present invention, but the present invention absolutely not only only limits to following these embodiment.Percentage all is weight percentage in the prescription, and employed former medicine and auxiliary agent are other producers and buy.
Formulation examples is as follows:
Example one, 10.1% tetramycin thifluzamide suspending agent
Example two, 25.5% tetramycin thifluzamide suspending agent
Example three, 9.3% tetramycin thifluzamide suspending agent
Example four, 8.8% tetramycin thifluzamide aqua
Example five, 12% tetramycin thifluzamide suspending agent
Example six, 6% tetramycin thifluzamide suspending agent
Example seven, 18% tetramycin thifluzamide suspending agent
Example eight, 11% tetramycin thifluzamide aqua
Example nine, 6.2% tetramycin thifluzamide suspending agent
Example ten, 15.3% tetramycin thifluzamide suspending agent
Select above example to prevent and treat the field trial of rice sheath blight disease, the prescription of determining is prevented and treated the effect of rice sheath blight disease; Simultaneously by with the contrast of the effect of 10% tetramycin SC and 10% thifluzamide SC, verify the synergistic effect after composite.Concrete test method data are as follows:
6% tetramycin thifluzamide suspending agent and other preparation are done the test of pesticide effectiveness of field control rice sheath blight disease.Test site is Xiaogan Prefecture, Hubei Province Yingcheng City, and the time is on June 25th, 2012, test each and handle three repetitions, and the residential quarter randomized arrangement, each residential quarter area is 80m
2, adopt the back-pack electric compression sprayer, dispenser was sunny calm the same day, and the planting habit of all residential quarters all planting habit with the locality is identical, records the dispenser same day and the synoptic data in a week thereafter, and is specific as follows:
Table 2 duration of test meteorological data
Investigation method is: fixed 2 points of each residential quarter diagonal, and every some straight ahead is decided 25 clumps, and fixed point investigation in the 7th day, 21 days is investigated each residential quarter disease and is referred to after the dispenser, calculates preventive effect, and carries out the new multipole difference analysis of Deng Kenshi.
Table 36% tetramycin thifluzamide suspending agent and different medicament are to the preventive effect of rice sheath blight disease
Annotate: data are the mean value that repeats for 3 times in the table, and letter is all Duncan testing differentia remarkable time mutually: in June, 2012 place; Yingcheng City, Hubei
From above-mentioned data as can be seen, tetramycin and thifluzamide complex preparation behind medicine 7 days preventive effects all above 76%, and 10% tetramycin SC, 7 days preventive effects behind medicine are 44.81%, the preventive effect of 10% thifluzamide SC is 42.21%, compare 10% tetramycin SC, 10% thifluzamide SC, the complex preparation synergistic effect is extremely remarkable.Simultaneously, behind medicine 21 days, complex preparation all surpassed 85% to the preventive effect of rice sheath blight disease, and compares with 10% tetramycin SC, 10% thifluzamide SC, and the preparation after composite has prolonged the lasting period, and drug effect obviously improves.In field trial, testing crew is estimated all complex preparations to rice safety, no poisoning.Obviously, the complex preparation synergistic effect is remarkable, has prolonged the lasting period, alleviates peasant's the amount of labour, and very high practicality is arranged.
Claims (3)
1. contain the bactericidal composition of tetramycin, it is characterized in that: described active component is made up of tetramycin and thifluzamide, and the weight ratio of tetramycin and thifluzamide is 1:100~50:1.
2. bactericidal composition according to claim 1 is characterized in that: make suspending agent, aqua by active ingredient and auxiliary material.
3. according to claim 1 or the described bactericidal composition of claim 2, it is characterized in that: be used for preventing and treating rice sheath blight disease.
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CN201310244974XA CN103300024A (en) | 2013-06-19 | 2013-06-19 | Sterilization composition containing tetramycin |
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CN201310244974XA CN103300024A (en) | 2013-06-19 | 2013-06-19 | Sterilization composition containing tetramycin |
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Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103583532A (en) * | 2013-11-26 | 2014-02-19 | 辽宁微科生物工程有限公司 | Tetramycin complex and application |
CN103609572A (en) * | 2013-11-30 | 2014-03-05 | 海利尔药业集团股份有限公司 | Sterilization composition containing tetramycin and amino-oligosaccharin |
CN103636635A (en) * | 2013-11-28 | 2014-03-19 | 北京燕化永乐生物科技股份有限公司 | Pesticide composition |
CN103636622A (en) * | 2013-12-02 | 2014-03-19 | 海利尔药业集团股份有限公司 | Sterilizing composition containing tetramycin and bromothalonil |
CN104585195A (en) * | 2013-11-26 | 2015-05-06 | 辽宁微科生物工程有限公司 | Tetramycin compound and application thereof |
CN104585196A (en) * | 2013-11-26 | 2015-05-06 | 辽宁微科生物工程有限公司 | Tetramycin compound and application thereof |
CN104604895A (en) * | 2013-11-26 | 2015-05-13 | 辽宁微科生物工程有限公司 | Tetramycin compound and application |
CN104621147A (en) * | 2013-11-26 | 2015-05-20 | 辽宁微科生物工程有限公司 | Tetramycin compound and application |
CN104982445A (en) * | 2015-07-25 | 2015-10-21 | 海利尔药业集团股份有限公司 | Bactericidal composition comprising fluxapyroxad and tetramycin |
CN105010361A (en) * | 2015-07-25 | 2015-11-04 | 海利尔药业集团股份有限公司 | Sterilization composition containing tetramycin and boscalid |
CN105432638A (en) * | 2015-09-11 | 2016-03-30 | 广东中迅农科股份有限公司 | Pesticide composition containing tetramycin and propamocarb |
Citations (1)
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CN101755825A (en) * | 2009-11-23 | 2010-06-30 | 陈章艳 | Bactericide composition containing thifluzamide |
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2013
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Patent Citations (1)
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CN101755825A (en) * | 2009-11-23 | 2010-06-30 | 陈章艳 | Bactericide composition containing thifluzamide |
Non-Patent Citations (1)
Title |
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任跃全等: "四霉素防治水稻主要病害的应用技术", 《科技致富向导》, no. 19, 31 July 2011 (2011-07-31), pages 38 * |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103583532B (en) * | 2013-11-26 | 2015-08-05 | 辽宁微科生物工程有限公司 | Tetramycin complex and application |
CN104604895A (en) * | 2013-11-26 | 2015-05-13 | 辽宁微科生物工程有限公司 | Tetramycin compound and application |
CN104604895B (en) * | 2013-11-26 | 2017-05-10 | 辽宁微科生物工程股份有限公司 | Tetramycin compound and application |
CN104585195B (en) * | 2013-11-26 | 2016-08-17 | 辽宁微科生物工程股份有限公司 | Tetramycin complex and application |
CN103583532A (en) * | 2013-11-26 | 2014-02-19 | 辽宁微科生物工程有限公司 | Tetramycin complex and application |
CN104585196A (en) * | 2013-11-26 | 2015-05-06 | 辽宁微科生物工程有限公司 | Tetramycin compound and application thereof |
CN104585196B (en) * | 2013-11-26 | 2016-08-17 | 辽宁微科生物工程股份有限公司 | Tetramycin complex and application |
CN104621147A (en) * | 2013-11-26 | 2015-05-20 | 辽宁微科生物工程有限公司 | Tetramycin compound and application |
CN104585195A (en) * | 2013-11-26 | 2015-05-06 | 辽宁微科生物工程有限公司 | Tetramycin compound and application thereof |
CN103636635A (en) * | 2013-11-28 | 2014-03-19 | 北京燕化永乐生物科技股份有限公司 | Pesticide composition |
CN103609572B (en) * | 2013-11-30 | 2016-01-20 | 海利尔药业集团股份有限公司 | A kind of bactericidal composition containing tetramycin and amino-oligosaccharide |
CN103609572A (en) * | 2013-11-30 | 2014-03-05 | 海利尔药业集团股份有限公司 | Sterilization composition containing tetramycin and amino-oligosaccharin |
CN103636622A (en) * | 2013-12-02 | 2014-03-19 | 海利尔药业集团股份有限公司 | Sterilizing composition containing tetramycin and bromothalonil |
CN104982445A (en) * | 2015-07-25 | 2015-10-21 | 海利尔药业集团股份有限公司 | Bactericidal composition comprising fluxapyroxad and tetramycin |
CN105010361A (en) * | 2015-07-25 | 2015-11-04 | 海利尔药业集团股份有限公司 | Sterilization composition containing tetramycin and boscalid |
CN105432638A (en) * | 2015-09-11 | 2016-03-30 | 广东中迅农科股份有限公司 | Pesticide composition containing tetramycin and propamocarb |
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Address after: 102488 No. 8, Liangxiang, Beijing, Fangshan District Applicant after: Beijing Yanhua Yongle Biotechnology Co., Ltd. Address before: 102488 No. 8, Liangxiang, Beijing, Fangshan District Applicant before: Beijing Yoloo Pesticide Co., Ltd. |
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Free format text: CORRECT: APPLICANT; FROM: BEIJING YOLOO PESTICIDE CO., LTD. TO: BEIJING YANHUA YONGLE BIOTECHNOLOGYCO., LTD. |
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Application publication date: 20130918 |