CN104013573B - Available iodine content is the liquid PVP-I of 5-12% - Google Patents
Available iodine content is the liquid PVP-I of 5-12% Download PDFInfo
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- CN104013573B CN104013573B CN201410286042.6A CN201410286042A CN104013573B CN 104013573 B CN104013573 B CN 104013573B CN 201410286042 A CN201410286042 A CN 201410286042A CN 104013573 B CN104013573 B CN 104013573B
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Abstract
The present invention relates to a kind of antibacterial-anti-inflammatory drug, a kind of available iodine content is the liquid PVP-I of 5 12%, is to be prepared from by the raw material of following weight percents, iodine 5.2% ~ 12.24%；Polyvinylpyrrolidone 10% ~ 24%；KI 2% ~ 4.8%；Potassiumiodate 0.1% ~ 0.24%；Ethanol 15% ~ 36%；Water surplus.Available iodine content of the present invention is the liquid PVP-I of 5 12%, for rufous thick liquid, soluble in water, its stable performance, fungicidal effectiveness is strong, have no stimulation, it is applicable to the sterilization of operative site, skin and mucosa, can also be used for the sterilization of breeding water body, the bacteriosis that preventing and treating aquiculture animal is caused by vibrios, Aeromonas hydrophila, tarda etc., it is additionally operable to livestock and poultry pouity dwelling place environment disinfected, various bacteria, gemma, virus, fungi etc. are had killing action, be a kind of well containing iodine medical bactericide and health and epidemic prevention disinfectant.
Description
Technical field
The present invention relates to a kind of antibacterial-anti-inflammatory drug, specifically a kind of high amount of liquid PVP-I.
Background technology
PVP-I (PVP-I), is a kind of iodine-containing disinfectant, by release free-iodine, destroys thalline metabolism, makes thin
Bacterium etc. are microorganism deactivated, and bacterium, virus and fungi are all had good killing action.It is usually used in operative site, skin and mucosa
Sterilization；Can also be used for the sterilization of breeding water body, preventing and treating aquiculture animal is by vibrios, Aeromonas hydrophila, tarda etc.
The bacteriosis caused；It is additionally operable to livestock and poultry pouity dwelling place environment disinfected.
PVP-I in the market, available iodine content 9% ~ 12% for yellowish-brown to rufous amorphous powder,
Typically will be diluted to available iodine time actually used between 0.5% ~ 2%, and need to add during the dilution of the PVP-I of powder
Second alcohol and water, in addition it is also necessary to add sodium alkyl benzene sulfonate and citric acid (if application for a patent for invention publication No. is CN102475678A
Product) or add disodium hydrogen phosphate and citric acid (if application for a patent for invention publication No. is the product of CN102475679A), work
Skill is the most more complicated, loaded down with trivial details.
Domestic existing PVP-I, available iodine content 5% ~ 12% can only be pulverulent solids, and the poly-dimension of liquid
In ketone iodine, the effective content of iodine can only be below 5%, generally 0.1%, 0.5%, 1%, 2% several specifications.Its technical reason is because
In current PVP-I, it is necessary to assure polyvinylpyrrolidone (PVP) and iodine (I2) part by weight at about 9:1.When poly-
When vinylpyrrolidone (PVP) is less than this ratio, iodine just can not be stablized, and is prone to volatilization when producing and preserve and reduces and contain
Amount.And polyvinylpyrrolidone and iodine are all solids, so available iodine content reaches 10%(most 12%) time, the most do not add second
Alcohol or the space of water equal solvent.
Summary of the invention
The present invention is to solve complex process, loaded down with trivial details and liquid when the dilution of existing high-load powder PVP-I uses
PVP-I in the relatively low problem of the effective content of iodine, it is provided that a kind of high amount of liquid PVP-I.
The present invention is achieved by the following technical solutions: high amount of liquid PVP-I, is by following weight percents
Raw material be prepared from,
Iodine 5.2% ~ 12.24%
Polyvinylpyrrolidone 10% ~ 24%
KI 2% ~ 4.8%
Potassiumiodate 0.1% ~ 0.24%
Ethanol 15% ~ 36%
Water surplus.
The content of high amount of liquid its available iodine of PVP-I of the present invention is 5% ~ 12%.But polyethylene in the present invention
The content of pyrrolidones (PVP) only has 10% ~ 24%, adds second alcohol and water and has conceded space, use 2% ~ 4.8% during for preparing liquid
KI and 0.1% ~ 0.24% Potassiumiodate instead of substantial amounts of polyvinylpyrrolidone (PVP), can guarantee that the present invention equally
The stability of described high amount of liquid PVP-I, its stability is more preferable relative to original PVP-I, is better than existing country
Standard, water solubility is more excellent simultaneously, and dilution only need to add water when using.
In the present invention, KI forms soluble complexes with iodine, and plays hydrotropy effect, and makes iodine stable, is difficult to wave
Send out.And complex reaction is reversible, therefore remain to keep the sterilizing power of iodine.And Potassiumiodate has certain stability to iodine, it is a kind of
Strong oxidizer, makes the reduzate iodine anion of free-iodine be oxidized to iodine, and keeps disinfection vitality.
If the content of polyvinylpyrrolidone is less than 10% ~ 24%, the stability of iodine will be affected；If more than 24%, poly-
Tie up ketone iodine excessively thickness and cannot produce.
If the content of KI is less than 2% ~ 4.8%, the stability of iodine will reduce；If more than 2% ~ 4.8%, then can be because increasing
Unnecessary cost and lose market value.
If the content of Potassiumiodate is less than 0.1% ~ 0.24%, the stability of iodine will reduce；If more than 0.1% ~ 0.24%, will
Increase unnecessary cost.
Time specifically used, adding water and high amount of liquid PVP-I is diluted to available iodine content is molten between 0.1% ~ 2%
Liquid, it is not necessary to other solvents, without heating.Use the preparation side of high amount of liquid PVP-I of the present invention
Method, the high amount of liquid PVP-I stability prepared is more preferable, and water solubility is more excellent, uses more convenient.
The preparation method of described high amount of liquid PVP-I,
The steps include:
(1) ethanol of 15% ~ 36% is weighed by gross weight；
(2) by the 5.2% ~ 12.24% of gross weight iodine and gross weight 2% ~ 4.8% KI put in ethanol, stir
Mix dissolving, obtain A liquid；
(3) water of surplus is weighed；
(4) polyvinylpyrrolidone of the 10% ~ 24% of gross weight is put in water, stirring and dissolving, obtain B liquid；
(5) A liquid is mixed with B liquid, and add gross weight 0.1% ~ 0.24% Potassiumiodate, uniform stirring is allowed to the most molten
Solve, obtain high amount of liquid PVP-I.
High amount of liquid PVP-I of the present invention, for rufous thick liquid, soluble in water, its stable performance,
Fungicidal effectiveness is strong, has no stimulation, it is adaptable to operative site, skin and mucosa sterilization it can also be used to the sterilization of breeding water body, anti-
Control the bacteriosis that aquiculture animal is caused by vibrios, Aeromonas hydrophila, tarda etc., be additionally operable to livestock and poultry pouity dwelling place
Environment disinfected, has killing action to various bacteria, gemma, virus, fungi etc., is that one well contains iodine medical bactericide and defends
Biological and ecological methods to prevent plant disease, pests, and erosion epidemic disease disinfectant.And high amount of liquid PVP-I stability of the present invention is better than existing national standard, water-soluble
It is better than the PVP-I of the identical powder of content of iodine.
Experiment: the stability experiment of high amount of liquid PVP-I
Experiment 1: available iodine content is the high amount of liquid PVP-I of 5%
High amount of liquid PVP-I in this experiment, is to be prepared from by the raw material of following weight percents,
Iodine 5.2%
Polyvinylpyrrolidone 10%
KI 2%
Potassiumiodate 0.1%
Ethanol 15%
Water surplus.
The PVP-I powder (B) of high amount of liquid PVP-I (A) of the present invention with high-load is diluted to advising
The product (available iodine content is the solution of 1%) of lattice, carries out stability and compares, by the detection method of national standard be: respectively take solution
10ml, is placed in 50ml conical flask, shakes up (in bottle, neck is sure not to stain), and bottleneck covers a filter moistened with starch indicator solution
Paper, places.Standard is 60 seconds not aobvious bluenesss.
Table 1 stability comparative result
Experiment 2: available iodine content is the high amount of liquid PVP-I of 10%
High amount of liquid PVP-I in this experiment, is to be prepared from by the raw material of following weight percents,
Iodine 10.4%
Polyvinylpyrrolidone 20%
KI 4%
Potassiumiodate 0.2%
Ethanol 30%
Water surplus.
The PVP-I powder (B) of high amount of liquid PVP-I (A) of the present invention with high-load is diluted to advising
The product (available iodine content is the solution of 1%) of lattice, carries out stability and compares, by the detection method of national standard be: respectively take solution
10ml, is placed in 50ml conical flask, shakes up (in bottle, neck is sure not to stain), and bottleneck covers a filter moistened with starch indicator solution
Paper, places.Standard is 60 seconds not aobvious bluenesss.
Table 2 stability comparative result
Experiment 3: available iodine content is the high amount of liquid PVP-I of 12%
High amount of liquid PVP-I in this experiment, is to be prepared from by the raw material of following weight percents,
Iodine 12.24%
Polyvinylpyrrolidone 24%
KI 4.8%
Potassiumiodate 0.24%
Ethanol 36%
Water surplus.
The PVP-I powder (B) of high amount of liquid PVP-I (A) of the present invention with high-load is diluted to advising
The product (available iodine content is the solution of 1%) of lattice, carries out stability and compares, by the detection method of national standard be: respectively take solution
10ml, is placed in 50ml conical flask, shakes up (in bottle, neck is sure not to stain), and bottleneck covers a filter moistened with starch indicator solution
Paper, places.Standard is 60 seconds not aobvious bluenesss.
Table 3 stability comparative result
| Product | Stability | Evaluate |
| The product made after A dilution | 185 seconds not aobvious bluenesss | Excellent |
| The product made after B dilution | 65 seconds not aobvious bluenesss | Qualified |
Detailed description of the invention
Embodiment 1
The preparation method of described high amount of liquid PVP-I,
The steps include:
(1) ethanol of 15% is weighed by gross weight；
(2) by the 5.2% of gross weight iodine and gross weight 2% KI put in ethanol, stirring and dissolving, obtain A liquid；
(3) weigh gross weight 67.7% water；
(4) polyvinylpyrrolidone of the 10% of gross weight is put in water, stirring and dissolving, obtain B liquid；
(5) A liquid is mixed with B liquid, and add gross weight 0.1% Potassiumiodate, uniform stirring is allowed to be completely dissolved, i.e.
Obtain high amount of liquid PVP-I.
Embodiment 2
The preparation method of described high amount of liquid PVP-I,
The steps include:
(1) ethanol of 30% is weighed by gross weight；
(2) by the 10.4% of gross weight iodine and gross weight 4% KI put in ethanol, stirring and dissolving, obtain A
Liquid；
(3) weigh gross weight 35.4% water；
(4) polyvinylpyrrolidone of the 20% of gross weight is put in water, stirring and dissolving, obtain B liquid；
(5) A liquid is mixed with B liquid, and add gross weight 0.2% Potassiumiodate, uniform stirring is allowed to be completely dissolved, i.e.
Obtain high amount of liquid PVP-I.
Embodiment 3
The preparation method of described high amount of liquid PVP-I,
The steps include:
(1) ethanol of 36% is weighed by gross weight；
(2) by the 12.24% of gross weight iodine and gross weight 4.8% KI put in ethanol, stirring and dissolving,
A liquid；
(3) weigh gross weight 22.72% water；
(4) polyvinylpyrrolidone of the 24% of gross weight is put in water, stirring and dissolving, obtain B liquid；
(5) A liquid is mixed with B liquid, and add gross weight 0.24% Potassiumiodate, uniform stirring is allowed to be completely dissolved, i.e.
Obtain high amount of liquid PVP-I.
Embodiment 4
The preparation method of described high amount of liquid PVP-I,
The steps include:
(1) ethanol of 18% is weighed by gross weight；
(2) by the 5.2% of gross weight iodine and gross weight 2% KI put in ethanol, stirring and dissolving, obtain A liquid；
(3) weigh gross weight 62.7% water；
(4) polyvinylpyrrolidone of the 12% of gross weight is put in water, stirring and dissolving, obtain B liquid；
(5) A liquid is mixed with B liquid, and add gross weight 0.1% Potassiumiodate, uniform stirring is allowed to be completely dissolved, i.e.
Obtain high amount of liquid PVP-I.
Claims (2)
1. available iodine content is the liquid PVP-I of 5-12%, it is characterised in that be to be prepared by the raw material of following weight percents
,
Iodine 5.2% ~ 12.24%
Polyvinylpyrrolidone 10% ~ 24%
KI 2% ~ 4.8%
Potassiumiodate 0.1% ~ 0.24%
Ethanol 15% ~ 36%
Water surplus.
2. the available iodine content described in claim 1 is the preparation method of liquid PVP-I of 5-12%, it is characterised in that
The steps include:
(1) ethanol of 15% ~ 36% is weighed by gross weight；
(2) by the 5.2% ~ 12.24% of gross weight iodine and gross weight 2% ~ 4.8% KI put in ethanol, stir molten
Solve, obtain A liquid；
(3) water of surplus is weighed；
(4) polyvinylpyrrolidone of the 10% ~ 24% of gross weight is put in water, stirring and dissolving, obtain B liquid；
(5) A liquid is mixed with B liquid, and add gross weight 0.1% ~ 0.24% Potassiumiodate, uniform stirring is allowed to be completely dissolved,
Obtain the liquid PVP-I that available iodine content is 5-12%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410286042.6A CN104013573B (en) | 2014-06-25 | 2014-06-25 | Available iodine content is the liquid PVP-I of 5-12% |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410286042.6A CN104013573B (en) | 2014-06-25 | 2014-06-25 | Available iodine content is the liquid PVP-I of 5-12% |
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| CN104013573A CN104013573A (en) | 2014-09-03 |
| CN104013573B true CN104013573B (en) | 2016-08-24 |
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Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104224825A (en) * | 2014-09-16 | 2014-12-24 | 王子章 | Disinfectant and preparation method thereof |
| CN105853397B (en) * | 2016-04-26 | 2019-03-05 | 上海宇昂新材料科技有限公司 | A kind of povidone iodine concentrate and its preparation method and application |
| CN106386853A (en) * | 2016-08-30 | 2017-02-15 | 四川创美克科技有限公司 | Multi-effect active iodine disinfectant as well as preparation method and application thereof |
| CN108403671B (en) * | 2018-06-11 | 2021-04-27 | 佛山市南海东方澳龙制药有限公司 | Povidone-iodine solution and preparation method thereof |
| CN109362797A (en) * | 2018-12-04 | 2019-02-22 | 怀化学院 | Iodic disinfecting liquid and preparation method thereof |
| CN110037940A (en) * | 2019-05-22 | 2019-07-23 | 浙江欧洁科技股份有限公司 | A kind of sterilizing oral disinfection mouthwash and preparation method thereof and application method |
| CN111657297B (en) * | 2020-07-10 | 2022-05-03 | 四川成邦药业有限公司 | Chelated povidone iodine solution and preparation method thereof |
| CN114672182A (en) * | 2020-12-24 | 2022-06-28 | 苏州北辰新材料科技有限公司 | Coating composition, preparation method thereof and coating |
| CN112841181B (en) * | 2020-12-31 | 2022-06-17 | 佛山市正典生物技术有限公司 | Stable iodine-containing disinfectant and preparation method thereof |
| CN113288913A (en) * | 2021-05-25 | 2021-08-24 | 厦门惠盈动物药业有限公司 | Povidone iodine solution and preparation method thereof |
| CN114931586B (en) * | 2021-06-25 | 2023-09-29 | 浙江科瑞特生物科技有限公司 | Povidone-iodine solution for animal oral administration and preparation method thereof |
| CN113768951A (en) * | 2021-08-25 | 2021-12-10 | 广东瑞吉生物技术有限公司 | High-polyiodide preparation and preparation method and application thereof |
| CN115337410A (en) * | 2022-08-30 | 2022-11-15 | 四川大学华西医院 | Tissue staining agent for endoscopic screening of canceration and preparation method thereof |
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| CN102949338A (en) * | 2012-11-17 | 2013-03-06 | 河南省康星药业有限公司 | 5% povidone-iodine solution for dairy cattle with strong stability and preparation process thereof |
| CN102973601A (en) * | 2012-12-26 | 2013-03-20 | 哈尔滨五牛生物技术开发有限公司 | Medicated bath film forming agent for preventing bouine mastitis and preparation method of medicated bath film forming agent |
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