CN110037940A - A kind of sterilizing oral disinfection mouthwash and preparation method thereof and application method - Google Patents
A kind of sterilizing oral disinfection mouthwash and preparation method thereof and application method Download PDFInfo
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- CN110037940A CN110037940A CN201910429206.9A CN201910429206A CN110037940A CN 110037940 A CN110037940 A CN 110037940A CN 201910429206 A CN201910429206 A CN 201910429206A CN 110037940 A CN110037940 A CN 110037940A
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- mouthwash
- solution
- sterilizing oral
- sterilizes
- essence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
Abstract
The present invention relates to mouthwash technical field more particularly to a kind of sterilizing oral disinfection mouthwash and preparation method thereof and application methods.The component of this sterilizing oral disinfection mouthwash and the weight percent of each component are as follows: povidone iodine 4.5% ~ 5.5%;Potassiumiodate 0 ~ 0.05%;Potassium iodide 0.1% ~ 0.15%;Polyvinylpyrrolidone 0.5% ~ 0.8%;Lauryl sodium sulfate 0.05% ~ 0.1%;Glycerol 1% ~ 3%;Polyethylene glycol 400 0.4% ~ 0.6%;Citric acid 0.15% ~ 0.25%;Auxiliary material 0% ~ 0.1%;Freshener 0.5% ~ 1.2%;Purify water surplus.The mouthwash has the characteristics that disinfection effect is good, irritation is low, harmless and stability is good, the resting period is long.
Description
Technical field
The present invention relates to mouthwash technical field more particularly to a kind of sterilizing oral disinfection mouthwash and preparation method thereof and
Application method.
Background technique
Oral cavity is the good interior environment that multiple-microorganism is lived away from home and bred, when body immunity decline, oral cavity itself
Self-cleaning ability will reduce, and at this moment oral bacteria organic will take advantage of, and cause oral inflammation, gingivitis, canker sore, dental hemorrhage
Etc. a series of oral problems.With the improvement of living standards, oral health is increasingly valued by people, while oral cavity is protected
Strong mouthwash also proposed more requirements, and the function of some auxiliary prevention mouth diseases is also added other than clean tooth
Energy.
Most of oral problem, mainly due in oral cavity there are caused by pathogenic bacteria, control oral cavity pathogen is
The main task for preventing mouth disease.After after brushing, mouthwash is sterilized using sterilizing oral, is conducive to further clean mouth
Chamber effectively reduces bacteria breed, prevents oral problem.
Mouthwash type currently on the market is more, can be divided into two classes, and one kind is civilian common mouthwash, and another kind of is tool
There is the medical mouthwash of therapeutic effect, but can really play a role seldom.
For example the patent document of Publication No. CN107049867A discloses the dedicated mouthwash of such a Medical oral cavity,
Raw material constituent is made of following ratio in parts by weight: 25-30 parts of gluconic acid chlorhexidine, 15-20 parts of glucose, and nitre difficult to understand
It 10-20 parts of azoles, 5-12 parts of metronidazole, 10-15 parts of glycerol, 10-16 parts of ethyl alcohol, 8-14 parts of sodium chloride, dense Peppermint Water 5-10 parts, goes
40-50 parts of ionized water.Contain gluconic acid chlorhexidine in this mouthwash, gluconic acid chlorhexidine, which is used for a long time, will cause tooth
And tongue jaundice, and the sense of taste can be caused to change, there is drug resistance.
The patent document of Publication No. CN108379098A discloses such a mouthwash for another example, is contained by following percentages
The supplementary material of amount forms: sodium chlorite 0.2-0.25%, pH adjusting agent 0.5-1% (v/v), stabilizer 1.1-2.1%, flavoring agent
0.1-0.2%, preservative 0.1-0.2%, solubilizer 0.1-0.2%, surplus are purified water.Contain chlorous acid in this mouthwash
Sodium stimulates oral mucosa with irritation, unhealthful.
The patent document of for another example Publication No. CN105030818A discloses such a I type povidone iodine gargle
(0.1% available iodine) and its preparing process, component are as follows: povidone iodine, disodium hydrogen phosphate, citric acid, propylene glycol, glycerol, sweet
Reveal alcohol, saccharin sodium, poloxamer188, ethyl alcohol, water-soluble peppermint oil, gaultherolin, purified water.This gargle contains
The ethyl alcohol of 4.5%-6%, and stability is bad, and the activity of available iodine is high, increases cost.
Summary of the invention
The invention solves the above problem, provide a kind of low, stable, health the sterilizing oral disinfection mouthwash of irritation and
Preparation method and application method.
The technical solution that the present invention solves the problems, such as is to provide a kind of sterilizing oral disinfection mouthwash, component and each group
The weight percent divided is as follows: povidone iodine 4.5% ~ 5.5%;Potassiumiodate 0 ~ 0.05%;Potassium iodide 0.1% ~ 0.15%;It is poly-
Vinylpyrrolidone 0.5% ~ 0.8%;Lauryl sodium sulfate 0.05% ~ 0.1%;Glycerol 1% ~ 3%;Polyethylene glycol 400
0.4% ~ 0.6%;Citric acid 0.15% ~ 0.25%;Auxiliary material 0% ~ 0.1%;Freshener 0.5% ~ 1.2%;Purify water surplus.
Preferably, the auxiliary material includes saccharin sodium.
Preferably, the freshener includes water-soluble peppermint oil 0 ~ 0.2%.
Preferably, the freshener includes essence 0.5% ~ 1%.
Preferably, the water-soluble peppermint oil main component is l-menthol.
Preferably, the essence include jasmine flower essence, lily essence, increasing aroma from green tea essence, one of osmanthus flower fragrance or
It is several.
It is a further object to provide a kind of preparation methods of sterilizing oral disinfection mouthwash, including following step
It is rapid:
(1) povidone iodine is slowly added in the mixed liquor of purified water, glycerol and polyethylene glycol 400, stirring and dissolving obtains solution
1;
(2) Potassiumiodate and polyvinylpyrrolidone are dissolved in solution 1, obtain solution 3;
(3) lauryl sodium sulfate, potassium iodide, citric acid and auxiliary material are dissolved in purified water, obtain solution 2;
(4) solution 2 is added in solution 3 and stirs to get mixed solution, freshener and residue are then added into mixed solution
Purified water, be heated to 40 ~ 50 DEG C and stir 2.5 ~ 3.5h, obtain mouthwash.
A further object of the present invention is to provide a kind of application method of sterilizing oral disinfection mouthwash, and when use is dilute with water
After releasing 15 ~ 30 times, spue after the 40-80s that gargles.
Beneficial effects of the present invention:
1. adding povidone iodine, povidone iodine is loose compound made of elemental iodine and polymer support combine, water-soluble
For liquid in acidity, free-iodine can be released in water by being not required to the de- iodine of ethyl alcohol.Microorganism can be risen and be killed by the oxidation of iodine
Effect, and it is small to mucosa irritation, it is corrosion-free effect, toxicity it is low.Simultaneously as it is supported on carrier, in the solution by
Iodine is gradually released, a kind of slow releasing function is played, with the sterilizing power being maintained for a long time.
2. loading Potassiumiodate, lauryl sodium sulfate potassium iodide with polyvinylpyrrolidone, distinguish in the solution
Iodate ion and iodide ion are slowly released, and iodate ion and iodide ion are acted in the acid environment of povidone iodine aqueous solution
Lower reaction obtains iodine, increases effective iodine concentration in solution.Active iodine slow release, raising can not only be promoted to disappear by load
Kill the action time of bacterium, moreover it is possible to keep the stability of iodate ion and iodide ion, to reduce the decline of available iodine, can mention
The stability of high mouthwash, so that mouthwash is placed for a long time.
3. outside lauryl sodium sulfate iodate potassium carrier, moreover it is possible to, can be with as surfactant to improve cleaning action
Improve the saturate vision disadvantage of PVP-I liquid, color can be made thin out, it is easier to be accepted by the public.
4. adding citric acid, when it is acid for further adjusting solution environmental, also there is bactericidal effect.
5. mouthwash made from is concentrated type, and when use is diluted with water, to reduce cost.
Specific embodiment
It is a specific embodiment of the invention below, and technical scheme of the present invention will be further described, but this hair
It is bright to be not limited to these examples.
Embodiment 1
(1) under room temperature, 4.0g glycerol and 1.0g polyethylene glycol 400 is added in 120g purified water, is mixed and stirred for uniformly obtaining
Mixed liquor;Then 10.0g povidone iodine is slowly added into mixed liquor, is stirred to dissolve, obtain solution 1.
(2) under room temperature, 0.20g lauryl sodium sulfate, 0.15g saccharin sodium, 0.30g iodate are dissolved in 70g purified water
Potassium and 0.40g citric acid, stir evenly, and obtain solution 2.
(3) under room temperature, 0.06g Potassiumiodate and 1.60g polyvinylpyrrolidone are dissolved in 1 solution, obtain solution 3.
(4) solution 2 is added in solution 3, is stirred evenly, water-soluble peppermint oil is then added into its mixed solution
0.20g, 0.20g jasmine flower essence, heating are stirred 2.5 hours at 40 DEG C, can obtain mouthwash.The pH of the mouthwash is 2.5-
3.5。
Embodiment 2
(1) under room temperature, 5.0g glycerol and 1.0g polyethylene glycol 400 is added in 120g purified water, is mixed and stirred for uniformly obtaining
Mixed liquor;Then 10.5g povidone iodine is slowly added into mixed liquor, is stirred to dissolve, obtain solution 1.
(2) under room temperature, 0.20g lauryl sodium sulfate, 0.15g saccharin sodium, 0.30g iodate are dissolved in 70g purified water
Potassium and 0.40g citric acid, stir evenly, and obtain solution 2.
(3) under room temperature, 0.06g Potassiumiodate and 1.60g polyvinylpyrrolidone are dissolved in 1 solution, obtain solution 3.
(4) solution 2 is added in solution 3, is stirred evenly, 0.20g thin, water soluble is then added into its mixed solution
Lotus oil, 0.20g jasmine flower essence, heating are stirred 3 hours at 45 DEG C, can obtain mouthwash.
Embodiment 3
(1) under room temperature, 4.0g glycerol and 0.8g polyethylene glycol 400 is added in 120g purified water, is mixed and stirred for uniformly obtaining
Mixed liquor;Then 10.0g povidone iodine is slowly added into mixed liquor, is stirred to dissolve, obtain solution 1.
(2) under room temperature, 0.20g lauryl sodium sulfate, 0.15g saccharin sodium, 0.20g iodate are dissolved in 70g purified water
Potassium and 0.45g citric acid, stir evenly, and obtain solution 2.
(3) under room temperature, 0.06g Potassiumiodate and 1.20g polyvinylpyrrolidone are dissolved in 1 solution, obtain solution 3.
(4) solution 2 is added in solution 3, is stirred evenly, 0.15g thin, water soluble is then added into its mixed solution
Lotus oil, 0.20g jasmine flower essence, heating are stirred 3.5 hours at 50 DEG C, can obtain mouthwash.
Embodiment 4
(1) under room temperature, 4.5g glycerol and 1.0g polyethylene glycol 400 is added in 120g purified water, is mixed and stirred for uniformly obtaining
Mixed liquor;Then 11.0g povidone iodine is slowly added into mixed liquor, is stirred to dissolve, obtain solution 1.
(2) under room temperature, 0.20g lauryl sodium sulfate, 0.10g saccharin sodium, 0.30g iodate are dissolved in 70g purified water
Potassium and 0.40g citric acid, stir evenly, and obtain solution 2.
(3) under room temperature, 0.06g Potassiumiodate and 1.60g polyvinylpyrrolidone are dissolved in 1 solution, obtain solution 3.
(4) solution 2 is added in solution 3, is stirred evenly, 0.20g thin, water soluble is then added into its mixed solution
Lotus oil, 0.20g jasmine flower essence, heating are stirred 3 hours at 45 DEG C, can obtain mouthwash.
Specific embodiment described herein is only an example for the spirit of the invention.The neck of technology belonging to the present invention
The technical staff in domain can make various modifications or additions to the described embodiments or replace by a similar method
In generation, however, it does not deviate from the spirit of the invention or beyond the scope of the appended claims.
Claims (8)
1. a kind of sterilizing oral sterilizes mouthwash, it is characterised in that: the weight percent of its component and each component is as follows:
Povidone iodine 4.5% ~ 5.5%;
Potassiumiodate 0 ~ 0.05%;
Potassium iodide 0.1% ~ 0.15%;
Polyvinylpyrrolidone 0.5% ~ 0.8%;
Lauryl sodium sulfate 0.05% ~ 0.1%;
Glycerol 1% ~ 3%;
Polyethylene glycol 400 0.4% ~ 0.6%;
Citric acid 0.15% ~ 0.25%;
Auxiliary material 0% ~ 0.1%;
Freshener 0.5% ~ 1.2%;
Purify water surplus.
2. a kind of sterilizing oral according to claim 1 sterilizes mouthwash, it is characterised in that: the auxiliary material includes saccharin
Sodium.
3. a kind of sterilizing oral according to claim 1 sterilizes mouthwash, it is characterised in that: the freshener includes water-soluble
Property peppermint oil 0 ~ 0.2%.
4. a kind of sterilizing oral according to claim 1 sterilizes mouthwash, it is characterised in that: the freshener includes essence
0.5% ~ 1%。
5. a kind of sterilizing oral according to claim 3 sterilizes mouthwash, it is characterised in that: the water solubility peppermint oil master
Wanting ingredient is l-menthol.
6. a kind of sterilizing oral according to claim 4 sterilizes mouthwash, it is characterised in that: the essence includes Jasmine
One or more of essence, lily essence, increasing aroma from green tea essence, osmanthus flower fragrance.
7. a kind of preparation method of sterilizing oral disinfection mouthwash, feature shown in -6 any one exist according to claim 1
In: the following steps are included:
(1) povidone iodine is slowly added in the mixed liquor of purified water, glycerol and polyethylene glycol 400, stirring and dissolving obtains solution
1;
(2) Potassiumiodate and polyvinylpyrrolidone are dissolved in solution 1, obtain solution 3;
(3) lauryl sodium sulfate, potassium iodide, citric acid and auxiliary material are dissolved in purified water, obtain solution 2;
(4) solution 2 is added in solution 3 and stirs to get mixed solution, freshener and residue are then added into mixed solution
Purified water, be heated to 40 ~ 50 DEG C and stir 2.5 ~ 3.5h, obtain mouthwash.
8. a kind of application method of sterilizing oral disinfection mouthwash, feature shown in -6 any one exist according to claim 1
In: after 15 ~ 30 times are diluted with water when use, spue after the 40-80s that gargles.
Priority Applications (2)
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CN201910429206.9A CN110037940A (en) | 2019-05-22 | 2019-05-22 | A kind of sterilizing oral disinfection mouthwash and preparation method thereof and application method |
PCT/CN2020/087640 WO2020233371A1 (en) | 2019-05-22 | 2020-04-29 | Mouthwash for sterilization and disinfection of oral cavity, preparation method therefor and method for using same |
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CN201910429206.9A CN110037940A (en) | 2019-05-22 | 2019-05-22 | A kind of sterilizing oral disinfection mouthwash and preparation method thereof and application method |
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CN110037940A true CN110037940A (en) | 2019-07-23 |
Family
ID=67283053
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CN201910429206.9A Pending CN110037940A (en) | 2019-05-22 | 2019-05-22 | A kind of sterilizing oral disinfection mouthwash and preparation method thereof and application method |
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WO (1) | WO2020233371A1 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111328811A (en) * | 2020-04-16 | 2020-06-26 | 广州康健医学科技有限公司 | Low-concentration alcohol sterilization disinfectant and application thereof |
WO2020233371A1 (en) * | 2019-05-22 | 2020-11-26 | 浙江欧洁科技股份有限公司 | Mouthwash for sterilization and disinfection of oral cavity, preparation method therefor and method for using same |
CN112315974A (en) * | 2020-11-16 | 2021-02-05 | 乐泰药业有限公司 | Povidone iodine solution with enhanced stability and preparation method thereof |
CN113730345A (en) * | 2021-09-13 | 2021-12-03 | 佛山市仁汇医药科技有限公司 | Povidone iodine liquid preparation for oral bacteriostasis |
CN115501141A (en) * | 2022-10-21 | 2022-12-23 | 深圳市安杏舒电子商务有限公司 | Tooth brushing water and preparation method and use method thereof |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4954351A (en) * | 1983-03-02 | 1990-09-04 | Euroceltique S.A. | Method of producing standardized povidone iodine preparations and such preparations |
CN1481812A (en) * | 2003-07-23 | 2004-03-17 | 南京大学 | Spray formulation of providone iodine |
CN104013573A (en) * | 2014-06-25 | 2014-09-03 | 山西神龙天翼科技有限公司 | High-content liquid povidone-iodine |
CN104887623A (en) * | 2015-06-18 | 2015-09-09 | 李少博 | Type II povidone-iodine gargle containing 0.1% of available iodine and preparation process of type II povidone-iodine gargle |
CN108653201A (en) * | 2018-06-11 | 2018-10-16 | 佛山市南海东方澳龙制药有限公司 | Drip-proof type Betagen Solution and preparation method thereof |
CN108714138A (en) * | 2018-06-11 | 2018-10-30 | 佛山市南海东方澳龙制药有限公司 | Betagen Solution and preparation method thereof |
CN111657297A (en) * | 2020-07-10 | 2020-09-15 | 四川成邦药业有限公司 | Chelated povidone iodine solution and preparation method thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH061713A (en) * | 1992-06-16 | 1994-01-11 | Meiji Seika Kaisha Ltd | Treating agent for gingivitis and pyorrhea |
CN1245954C (en) * | 2004-08-08 | 2006-03-22 | 广东庆发药业有限公司 | Povidone iodine toothpaste and preparing method |
CN102919269A (en) * | 2012-11-02 | 2013-02-13 | 青岛康地恩药业股份有限公司 | Povidone-iodine disinfectant and preparation method thereof |
WO2016175727A1 (en) * | 2015-04-27 | 2016-11-03 | Aydin Kimya Sanayi Ve Ticaret Anonim Sirketi | Production method of iodophor based antimicrobial hydrogel |
CN105030818B (en) * | 2015-06-18 | 2018-07-03 | 李少博 | A kind of I types povidone iodine gargle and its preparing process |
CN105311050B (en) * | 2015-11-25 | 2018-07-13 | 上海银京医用卫生材料有限公司 | Seamless type Povidone Iodine Disinfection Solution |
CN106798749B (en) * | 2015-11-26 | 2020-03-10 | 洛阳惠中兽药有限公司 | Povidone-iodine film-forming disinfectant and preparation method and application thereof |
CN110037940A (en) * | 2019-05-22 | 2019-07-23 | 浙江欧洁科技股份有限公司 | A kind of sterilizing oral disinfection mouthwash and preparation method thereof and application method |
-
2019
- 2019-05-22 CN CN201910429206.9A patent/CN110037940A/en active Pending
-
2020
- 2020-04-29 WO PCT/CN2020/087640 patent/WO2020233371A1/en active Application Filing
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4954351A (en) * | 1983-03-02 | 1990-09-04 | Euroceltique S.A. | Method of producing standardized povidone iodine preparations and such preparations |
CN1481812A (en) * | 2003-07-23 | 2004-03-17 | 南京大学 | Spray formulation of providone iodine |
CN104013573A (en) * | 2014-06-25 | 2014-09-03 | 山西神龙天翼科技有限公司 | High-content liquid povidone-iodine |
CN104887623A (en) * | 2015-06-18 | 2015-09-09 | 李少博 | Type II povidone-iodine gargle containing 0.1% of available iodine and preparation process of type II povidone-iodine gargle |
CN108653201A (en) * | 2018-06-11 | 2018-10-16 | 佛山市南海东方澳龙制药有限公司 | Drip-proof type Betagen Solution and preparation method thereof |
CN108714138A (en) * | 2018-06-11 | 2018-10-30 | 佛山市南海东方澳龙制药有限公司 | Betagen Solution and preparation method thereof |
CN111657297A (en) * | 2020-07-10 | 2020-09-15 | 四川成邦药业有限公司 | Chelated povidone iodine solution and preparation method thereof |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020233371A1 (en) * | 2019-05-22 | 2020-11-26 | 浙江欧洁科技股份有限公司 | Mouthwash for sterilization and disinfection of oral cavity, preparation method therefor and method for using same |
CN111328811A (en) * | 2020-04-16 | 2020-06-26 | 广州康健医学科技有限公司 | Low-concentration alcohol sterilization disinfectant and application thereof |
CN111328811B (en) * | 2020-04-16 | 2021-07-23 | 广州康健医学科技有限公司 | Low-concentration alcohol sterilization disinfectant and application thereof |
CN112315974A (en) * | 2020-11-16 | 2021-02-05 | 乐泰药业有限公司 | Povidone iodine solution with enhanced stability and preparation method thereof |
CN113730345A (en) * | 2021-09-13 | 2021-12-03 | 佛山市仁汇医药科技有限公司 | Povidone iodine liquid preparation for oral bacteriostasis |
CN115501141A (en) * | 2022-10-21 | 2022-12-23 | 深圳市安杏舒电子商务有限公司 | Tooth brushing water and preparation method and use method thereof |
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