CN112315974A - Povidone iodine solution with enhanced stability and preparation method thereof - Google Patents
Povidone iodine solution with enhanced stability and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/18—Iodine; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
- A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
- A61K31/79—Polymers of vinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a povidone iodine solution with enhanced stability and a preparation method thereof. The povidone iodine solution is composed of povidone iodine, sodium dihydrogen phosphate, disodium hydrogen phosphate dodecahydrate, potassium iodate, sodium dodecyl sulfate and purified water, wherein the concentration of each raw material is as follows: 5-20 g/L of povidone iodine, 1-10 g/L of sodium dihydrogen phosphate, 0.5-2 g/L of disodium hydrogen phosphate dodecahydrate, 0.2-1.0 g/L of potassium iodate and 1-10 g/L of sodium dodecyl sulfate, and adjusting the pH value of a sodium hydroxide solution to 5.20-5.30. In the invention, sodium dihydrogen phosphate and disodium hydrogen phosphate dodecahydrate are used as pH value adjusting buffer pairs, so that the acid-base balance of the solution can be maintained, and a buffer effect can be achieved. The potassium iodate and the sodium dodecyl sulfate are used as pH stabilizers, the sodium hydroxide is used as a pH regulator, and the pH value of the povidone iodine solution can be controlled within a specified range, so that the stability of the effective iodine content is ensured, and the sterilization effect of the povidone iodine solution is maintained.
Description
Technical Field
The invention relates to a povidone iodine solution with enhanced stability and a preparation method thereof, belonging to the technical field of medicines.
Background
Povidone iodine (PVP-I) is amorphous powder with yellow-brown to reddish-brown color, and is an amorphous complex iodine formed by polyvinyl pyrrolidone (PVP) and iodine in a complex form by means of hydrogen bonds and other external forces. PVP forms a micro-cavity carrier, and iodide ions are complexed in the cavity of the microcapsule to form PVP-I. Under the condition of aqueous solution, the PVP has affinity effect on cell membranes, so that iodine can be directly introduced to the surfaces of the bacterial membranes, iodine molecules are slowly released, the cell membranes and proteins of the iodine molecules are damaged, and the effects of disinfection and sterilization are achieved. Povidone iodine has the characteristics of film forming, adhesion, detoxification, slow release, strong water solubility, broad-spectrum sterilization effect and the like, and is more and more widely applied to sterilization and disinfection of skin mucosa, operation, instruments and the like. The povidone iodine is a broad-spectrum strong sterilization disinfectant, has strong killing effect on viruses, bacteria, fungi and mould spores, and has small irritation to skin, low toxicity and lasting effect. Safe and simple use, no irritation to tissues, and is usually used for skin and mucosa disinfection, such as cleaning before operation, and disinfection of operation parts and wounds.
The povidone iodine solution is used as a disinfectant, has broad-spectrum antibacterial action, is used for disinfecting pyogenic dermatitis, dermatophyte infection, small-area mild burns and scalds, and is also used for disinfecting small-area skin and mucous membrane wounds, and is a novel clinical disinfection preservative. Compared with iodine tincture, the povidone iodine solution has the advantages of stable and quick sterilization effect, good water solubility, no irritation and volatility, mild and lasting effect, no toxicity, no harm, no irritation, difficult dyeing and no residue to organisms, is widely applied to clinic,
povidone iodine solid is stable in natural environment, but the stability of the solution is not ideal. Currently, commercially available povidone-iodine solutions are prescribed: povidone iodine (containing effective iodine 9.0-12.0%) 10g, purified water: and preparing a proper amount of povidone iodine solution into 1000 ml. The preparation process comprises the following steps: weighing povidone iodine according to the prescription amount, adding 9 times of purified water, soaking for 24 hours, adding 2/3 of purified water according to the prescription amount, diluting, fixing the volume, stirring, filtering and filling to obtain the povidone iodine. However, the stability of the povidone iodine solution is influenced by various factors such as temperature, pH value, light, concentration, packaging materials and the like, the pH value can be obviously changed, and the povidone iodine solution is easy to decompose and sublimate in the storage process, so that the content of effective iodine is reduced, the effective sterilization concentration cannot be achieved, the product quality is influenced, and a plurality of adverse effects are brought to production, storage and use.
Patent application with publication number CN104906127A discloses a povidone-iodine compound preparation with enhanced stability of effective iodine content and a preparation method thereof. The method proposes that the content of the effective iodine in the preparation can be kept relatively stable by adding the sodium hydroxide, but the method does not investigate the influence of different pH values on the stability of the preparation, and meanwhile, the method only adds the sodium hydroxide as a pH regulator, and has no obvious effect on keeping the stability of the preparation. This application is except adding pH regulator, has still increased pH value and has adjusted the buffering to with the pH stabilizer, more can the effectual stability that keeps povidone iodine solution pH value and content.
Disclosure of Invention
In order to solve the problems occurring in the art, the present invention aims to provide a povidone-iodine solution with enhanced stability and a preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical means:
the povidone iodine solution with enhanced stability comprises povidone iodine, sodium dihydrogen phosphate, disodium hydrogen phosphate dodecahydrate, potassium iodate, sodium dodecyl sulfate and purified water, wherein the concentration of each raw material is as follows:
5-20 g/L of povidone iodine, 1-10 g/L of sodium dihydrogen phosphate, 0.5-2 g/L of disodium hydrogen phosphate dodecahydrate, 0.2-1.0 g/L of potassium iodate and 1-10 g/L of sodium dodecyl sulfate, and adjusting the pH value of a sodium hydroxide solution to 5.20-5.30.
Among them, the preferred concentrations of the respective raw materials are as follows:
5g/L of povidone iodine, 2g/L of sodium dihydrogen phosphate, 1.5g/L of disodium hydrogen phosphate dodecahydrate, 0.3g/L of potassium iodate and 2.5g/L of sodium dodecyl sulfate, and the pH value of a sodium hydroxide solution is adjusted to be 5.2.
Wherein, the concentration of the sodium hydroxide solution is preferably 5% w/v.
Further, the invention also provides a method for preparing the povidone iodine solution, which is characterized by comprising the following steps of:
(1) weighing raw materials: weighing the raw materials according to the concentration of the raw materials;
(2) preparation of solution 1: adding the weighed sodium dihydrogen phosphate, disodium hydrogen phosphate dodecahydrate and potassium iodate into purified water to dissolve the sodium dihydrogen phosphate, the disodium hydrogen phosphate dodecahydrate and the potassium iodate to obtain a solution 1;
(2) preparation of solution 2: dissolving the weighed sodium dodecyl sulfate in purified water to obtain a solution 2;
(3) preparation of sodium hydroxide solution: taking sodium hydroxide, and adding purified water to prepare a sodium hydroxide solution;
(4) and adding purified water into the weighed povidone iodine, standing overnight, stirring the weighed povidone iodine by using an electric stirrer until the weighed povidone iodine is completely dissolved, adding the solution 1, continuously and fully stirring the solution, adding the solution 2, fully stirring the solution uniformly, adding purified water to a constant volume, stirring the solution uniformly, and adjusting the pH value to 5.20 to 5.30 by using a sodium hydroxide solution to obtain the povidone iodine solution with enhanced stability.
Wherein, the concentration of the sodium hydroxide solution is preferably 5% w/v.
Furthermore, the invention also provides application of the povidone iodine solution in preparation of a bactericide or a disinfectant.
Compared with the prior art, the invention has the beneficial effects that:
the invention provides a povidone iodine solution with enhanced stability and a preparation method thereof. In the invention, sodium dihydrogen phosphate and disodium hydrogen phosphate dodecahydrate are used as pH value adjusting buffer pairs, so that the acid-base balance of the solution can be maintained, and a buffer effect can be achieved. The pH value of the povidone iodine solution can be controlled within a specified range by adopting the raw material composition of the invention, thereby ensuring the stability of the effective iodine content and maintaining the sterilization efficacy of the povidone iodine solution.
Detailed Description
The invention will be further described with reference to specific embodiments, and the advantages and features of the invention will become apparent as the description proceeds. These examples are illustrative only and do not limit the scope of the present invention in any way. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention, and that such changes and modifications may be made without departing from the spirit and scope of the invention.
Example 1: preparation of povidone-iodine solution with enhanced stability
The povidone-iodine solution with enhanced stability in this example is prepared from the following raw materials: povidone iodine 10g, sodium dihydrogen phosphate 4g, disodium hydrogen phosphate dodecahydrate 0.9g, potassium iodate 0.5g, sodium dodecyl sulfate 5g, sodium hydroxide with pH adjusted to 5.3, and purified water added to 1000 mL.
The preparation method comprises the following steps:
(1) weighing the following raw materials in parts by weight:
10g of povidone iodine, 4g of sodium dihydrogen phosphate, 0.9g of disodium hydrogen phosphate dodecahydrate, 0.5g of potassium iodate and 5g of sodium dodecyl sulfate;
(2) preparation of solution 1: adding the weighed sodium dihydrogen phosphate, disodium hydrogen phosphate dodecahydrate and potassium iodate into purified water to dissolve the sodium dihydrogen phosphate, the disodium hydrogen phosphate dodecahydrate and the potassium iodate to obtain a solution 1;
(3) preparation of solution 2: dissolving the weighed sodium dodecyl sulfate in purified water to obtain a solution 2;
(4) preparation of sodium hydroxide solution: taking sodium hydroxide, and adding purified water to prepare 5% w/v sodium hydroxide solution;
(5) and adding purified water into the weighed povidone iodine, standing overnight, stirring by using an electric stirrer until the povidone iodine is completely dissolved, adding the solution 1, continuing to stir fully, adding the solution 2, and stirring fully until the solution is uniform. Adding purified water to reach a constant volume of 1000ml, stirring the mixture until the mixture is uniformly mixed, and adjusting the pH value to 5.30 by using a 5% w/v sodium hydroxide solution to obtain the povidone-iodine solution with enhanced stability.
Example 2: preparation of povidone-iodine solution with enhanced stability
The povidone-iodine solution with enhanced stability in this example is prepared from the following raw materials: 5g of povidone iodine, 2g of sodium dihydrogen phosphate, 1.5g of disodium hydrogen phosphate dodecahydrate, 0.3g of potassium iodate, 2.5g of sodium dodecyl sulfate, pH value adjusted to 5.2 by sodium hydroxide, and purified water added to 1000 mL.
The preparation method comprises the following steps:
(1) weighing the following raw materials in parts by weight:
5g of povidone iodine, 2g of sodium dihydrogen phosphate, 1.5g of disodium hydrogen phosphate dodecahydrate, 0.3g of potassium iodate and 2.5g of sodium dodecyl sulfate;
(2) preparation of solution 1: adding the weighed sodium dihydrogen phosphate, disodium hydrogen phosphate dodecahydrate and potassium iodate into purified water to dissolve the sodium dihydrogen phosphate, the disodium hydrogen phosphate dodecahydrate and the potassium iodate to obtain a solution 1;
(3) preparation of solution 2: dissolving the weighed sodium dodecyl sulfate in purified water to obtain a solution 2;
(4) preparation of sodium hydroxide solution: taking sodium hydroxide, and adding purified water to prepare 5% w/v sodium hydroxide solution;
(5) and adding purified water into the weighed povidone iodine, standing overnight, stirring by using an electric stirrer until the povidone iodine is completely dissolved, adding the solution 1, continuing to stir fully, adding the solution 2, and stirring fully until the solution is uniform. Adding purified water to reach a constant volume of 1000ml, stirring the mixture until the mixture is uniformly mixed, and adjusting the pH value to 5.20 by using a 5% w/v sodium hydroxide solution to obtain the povidone-iodine solution with enhanced stability.
Example 3: preparation of povidone-iodine solution with enhanced stability
The povidone-iodine solution with enhanced stability in this example is prepared from the following raw materials: 15g of povidone iodine, 6g of sodium dihydrogen phosphate, 2.0g of disodium hydrogen phosphate dodecahydrate, 1.0g of potassium iodate, 8.5g of sodium dodecyl sulfate, adjusting the pH value to 5.25 by using sodium hydroxide, and adding purified water to 1000 mL.
The preparation method comprises the following steps:
(1) weighing the following raw materials in parts by weight:
15g of povidone iodine, 6g of sodium dihydrogen phosphate, 2.0g of disodium hydrogen phosphate dodecahydrate, 1.0g of potassium iodate and 8.5g of sodium dodecyl sulfate;
(2) preparation of solution 1: adding the weighed sodium dihydrogen phosphate, disodium hydrogen phosphate dodecahydrate and potassium iodate into purified water to dissolve the sodium dihydrogen phosphate, the disodium hydrogen phosphate dodecahydrate and the potassium iodate to obtain a solution 1;
(3) preparation of solution 2: dissolving the weighed sodium dodecyl sulfate in purified water to obtain a solution 2;
(4) preparation of sodium hydroxide solution: taking sodium hydroxide, and adding purified water to prepare 5% w/v sodium hydroxide solution;
(5) and adding purified water into the weighed povidone iodine, standing overnight, stirring by using an electric stirrer until the povidone iodine is completely dissolved, adding the solution 1, continuing to stir fully, adding the solution 2, and stirring fully until the solution is uniform. Adding purified water to reach a constant volume of 1000ml, stirring the mixture until the mixture is uniformly mixed, and adjusting the pH value to 5.25 by using a 5% w/v sodium hydroxide solution to obtain the povidone-iodine solution with enhanced stability.
Experimental example 1 Effect verification
1. The test method comprises the following steps:
(1) pH value: see the Chinese pharmacopoeia 2015 edition four parts general rule 0631, which should be 3.0-6.5.
(2) Content determination: an appropriate amount of povidone-iodine solution (about equivalent to 1.25g of povidone-iodine) with precise amount is put into a beaker, added with water to 125mL and titrated with sodium thiosulfate titration solution (0.1mol/L) according to potentiometric titration (see 0701 in the four headings of the 2015 version of Chinese pharmacopoeia). Each 1ml of sodium thiosulfate titrant (0.1mol/L) corresponds to 12.69mg of iodine (I). The content of povidone iodine in the product is 8.5-12.0% (g/ml) calculated according to the effective iodine (I).
Measuring the content in 0, 1, 2, 3, 6, 9, and 12 months respectively.
2. And (3) test data statistics:
2.1 stability test with addition of different masses of sodium lauryl sulfate
The povidone-iodine solution was prepared as in example 1 except that the weight of the sodium lauryl sulfate therein was replaced with the weight of the sodium lauryl sulfate listed in table 1, and the results are shown in table 1:
table 1 shows the stability test results (available iodine content% (g/ml)) of sodium dodecyl sulfate added in different amounts
2.2 stability test with different quantities of Potassium iodate
The povidone-iodine solution was prepared as in example 1 except that the weight of potassium iodate therein was replaced with the weight of potassium iodate listed in table 2 and the results are shown in table 2:
table 2 stability test results (effective iodine content% (g/ml)) of potassium iodate added in different amounts
2.3 stability test by adding NaOH to adjust to different pH values
The povidone-iodine solution was prepared as in example 1 except that sodium hydroxide was added to adjust to different pH values, and the results are shown in table 3.
TABLE 3 stability test results (available iodine content% (g/ml)) with sodium hydroxide addition adjusted to different pH values
2.4 stability testing of the examples of the invention
The pH and available iodine content% (g/ml) of the povidone-iodine solutions prepared in examples 1 to 3 of the present invention were measured, and the results are shown in table 4.
TABLE 4 stability test results (effective iodine content% (g/ml)) for the examples of the present invention
2.5 in situ stability test
The original prescription of the povidone iodine solution is as follows: povidone iodine (containing effective iodine 9.0-12.0%) 10g, purified water: and preparing a proper amount of povidone iodine solution into 1000 ml.
The preparation process comprises the following steps: weighing povidone iodine according to the prescription amount, adding 9 times of purified water, soaking for 24 hours, adding 2/3 of purified water according to the prescription amount, diluting, fixing the volume, stirring, filtering and filling to obtain the povidone iodine.
The pH and available iodine content% (g/ml) of povidone-iodine solution prepared according to the original preparation process were measured, and the results are shown in table 5.
TABLE 5 stability test results (effective iodine content% (g/ml))
| Time (moon) | pH value | Effective iodine content |
| 0 | 3.5 | 10.52 |
| 1 | 2.61 | 10.13 |
| 2 | 2.59 | 10.05 |
| 3 | 2.57 | 9.84 |
| 6 | 2.55 | 9.13 |
| 9 | 2.51 | 8.62 |
| 12 | 2.42 | 8.41 |
| RSD(％) | 13.72 | 8.51 |
| The result of the detection | Fail to be qualified | Fail to be qualified |
The pH value is unqualified in 1 month of the stability test, and the content is unqualified in 9 months of the stability test.
3. Results
The pH value and the effective iodine content are used as evaluation indexes in the experiment, the pH value and the effective iodine content in the povidone iodine solution are measured by adopting an accelerated stability experiment method, the stability of the pH value and the effective iodine content in the povidone iodine solution is judged by Relative Standard Deviation (RSD), and the smaller the RSD value is, the more stable the product is.
As can be seen from Table 1, the amount of sodium dodecyl sulfate added is out of the range (1-10 g/L) indicated in the invention, and the stability of pH value and effective iodine content is not good enough.
As can be seen from Table 2, the amount of potassium iodate added (0.2-1.0 g/L) is out of the range indicated by the present invention, and the stability of pH value and available iodine content is not good enough.
As can be seen from Table 3, the pH and the available iodine content were not stable enough when the pH was adjusted to a value outside the range of the present invention (5.20 to 5.30) by adding NaOH.
As can be seen from Table 4, the addition of sodium dihydrogen phosphate, disodium hydrogen phosphate dodecahydrate, potassium iodate, sodium lauryl sulfate, and sodium hydroxide according to the embodiment of the present invention maintained good stability of available iodine content and pH.
As can be seen from table 5, the povidone-iodine solution prepared according to the original formulation has poor stability of pH and available iodine content.
The test results show that the pH value and the effective iodine content in the povidone-iodine solution can be more stable according to the raw material composition ratio and the preparation method.
Claims (6)
1. The povidone-iodine solution with enhanced stability is characterized by consisting of povidone-iodine, sodium dihydrogen phosphate, disodium hydrogen phosphate dodecahydrate, potassium iodate, sodium dodecyl sulfate and purified water, wherein the concentration of each raw material is as follows:
5-20 g/L of povidone iodine, 1-10 g/L of sodium dihydrogen phosphate, 0.5-2 g/L of disodium hydrogen phosphate dodecahydrate, 0.2-1.0 g/L of potassium iodate and 1-10 g/L of sodium dodecyl sulfate, and adjusting the pH value of a sodium hydroxide solution to 5.20-5.30.
2. The povidone-iodine solution of claim 1, wherein the concentrations of the respective raw materials are as follows:
5g/L of povidone iodine, 2g/L of sodium dihydrogen phosphate, 1.5g/L of disodium hydrogen phosphate dodecahydrate, 0.3g/L of potassium iodate and 2.5g/L of sodium dodecyl sulfate, and the pH value of a sodium hydroxide solution is adjusted to be 5.2.
3. The method of claim 1 or 2, wherein the sodium hydroxide solution has a concentration of 5% w/v.
4. A process for preparing the povidone-iodine solution of claim 1 or 2, comprising the steps of:
(1) weighing raw materials: weighing the raw materials according to the concentrations of the raw materials in the claim 1 or 2;
(2) preparation of solution 1: adding the weighed sodium dihydrogen phosphate, disodium hydrogen phosphate dodecahydrate and potassium iodate into purified water to dissolve the sodium dihydrogen phosphate, the disodium hydrogen phosphate dodecahydrate and the potassium iodate to obtain a solution 1;
(2) preparation of solution 2: dissolving the weighed sodium dodecyl sulfate in purified water to obtain a solution 2;
(3) preparation of sodium hydroxide solution: taking sodium hydroxide, and adding purified water to prepare a sodium hydroxide solution;
(4) and adding purified water into the weighed povidone iodine, standing overnight, stirring the weighed povidone iodine by using an electric stirrer until the weighed povidone iodine is completely dissolved, adding the solution 1, continuously and fully stirring the solution, adding the solution 2, fully stirring the solution uniformly, adding purified water to a constant volume, stirring the solution uniformly, and adjusting the pH value to 5.20 to 5.30 by using a sodium hydroxide solution to obtain the povidone iodine solution with enhanced stability.
5. The method of claim 4, wherein the sodium hydroxide solution is at a concentration of 5% w/v.
6. Use of a povidone-iodine solution as defined in any one of claims 1 to 3 in the preparation of a bactericide or disinfectant.
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Cited By (3)
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|---|---|---|---|---|
| CN113396930A (en) * | 2021-07-13 | 2021-09-17 | 武汉华扬动物药业有限责任公司 | Compound iodine disinfectant for aquaculture and preparation method thereof |
| CN113615708A (en) * | 2021-07-19 | 2021-11-09 | 西安交通大学 | Corneal contact lens nursing composition, preparation method and application |
| CN113855628A (en) * | 2021-11-02 | 2021-12-31 | 广东托尔沃登卫生用品有限公司 | Production process of povidone iodine disinfectant and product thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102550601A (en) * | 2010-12-22 | 2012-07-11 | 昆明振华制药厂有限公司 | Iodine disinfection liquid and preparation method thereof |
| CN102919269A (en) * | 2012-11-02 | 2013-02-13 | 青岛康地恩药业股份有限公司 | Povidone-iodine disinfectant and preparation method thereof |
| CN102949338A (en) * | 2012-11-17 | 2013-03-06 | 河南省康星药业有限公司 | 5% povidone-iodine solution for dairy cattle with strong stability and preparation process thereof |
| US20140255332A1 (en) * | 2011-08-25 | 2014-09-11 | Altacor Limited | Ophthalmic formulations |
| CN104906127A (en) * | 2015-06-03 | 2015-09-16 | 哈尔滨乐泰药业有限公司 | Povidone iodine compound preparation with enhanced available iodine content stability and preparation method thereof |
| CN110037940A (en) * | 2019-05-22 | 2019-07-23 | 浙江欧洁科技股份有限公司 | A kind of sterilizing oral disinfection mouthwash and preparation method thereof and application method |
| CN110051687A (en) * | 2019-04-21 | 2019-07-26 | 云南钰普生物科技有限公司 | A kind of drip proof type povidone iodine disinfection preserved material and its preparation method and application |
-
2020
- 2020-11-16 CN CN202011280535.0A patent/CN112315974B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102550601A (en) * | 2010-12-22 | 2012-07-11 | 昆明振华制药厂有限公司 | Iodine disinfection liquid and preparation method thereof |
| US20140255332A1 (en) * | 2011-08-25 | 2014-09-11 | Altacor Limited | Ophthalmic formulations |
| CN102919269A (en) * | 2012-11-02 | 2013-02-13 | 青岛康地恩药业股份有限公司 | Povidone-iodine disinfectant and preparation method thereof |
| CN102949338A (en) * | 2012-11-17 | 2013-03-06 | 河南省康星药业有限公司 | 5% povidone-iodine solution for dairy cattle with strong stability and preparation process thereof |
| CN104906127A (en) * | 2015-06-03 | 2015-09-16 | 哈尔滨乐泰药业有限公司 | Povidone iodine compound preparation with enhanced available iodine content stability and preparation method thereof |
| CN110051687A (en) * | 2019-04-21 | 2019-07-26 | 云南钰普生物科技有限公司 | A kind of drip proof type povidone iodine disinfection preserved material and its preparation method and application |
| CN110037940A (en) * | 2019-05-22 | 2019-07-23 | 浙江欧洁科技股份有限公司 | A kind of sterilizing oral disinfection mouthwash and preparation method thereof and application method |
Non-Patent Citations (4)
| Title |
|---|
| SACHIN S THAKUR: "Ex vivo evaluation of the influence of pH on the ophthalmic safety, antibacterial efficacy and storage stability of povidone-iodine", 《CLINICAL AND EXPERIMENTAL OPTOMETRY》 * |
| 周庆民，等: "pH值对聚维酮碘溶液稳定性的影响", 《中国乳业》 * |
| 姜山，等: "提高聚维酮碘溶液稳定性的方法", 《中国医院药学杂志》 * |
| 栗金权，等: "表面活性剂与增稠剂影响聚维酮碘溶液稳定性的研究", 《浙江化工》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113396930A (en) * | 2021-07-13 | 2021-09-17 | 武汉华扬动物药业有限责任公司 | Compound iodine disinfectant for aquaculture and preparation method thereof |
| CN113615708A (en) * | 2021-07-19 | 2021-11-09 | 西安交通大学 | Corneal contact lens nursing composition, preparation method and application |
| CN113855628A (en) * | 2021-11-02 | 2021-12-31 | 广东托尔沃登卫生用品有限公司 | Production process of povidone iodine disinfectant and product thereof |
| CN113855628B (en) * | 2021-11-02 | 2023-03-14 | 广东托尔沃登卫生用品有限公司 | Production process of povidone iodine disinfectant and product thereof |
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