CN105030818B - A kind of I types povidone iodine gargle and its preparing process - Google Patents
A kind of I types povidone iodine gargle and its preparing process Download PDFInfo
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- CN105030818B CN105030818B CN201510340407.3A CN201510340407A CN105030818B CN 105030818 B CN105030818 B CN 105030818B CN 201510340407 A CN201510340407 A CN 201510340407A CN 105030818 B CN105030818 B CN 105030818B
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- solution
- povidone iodine
- evenly
- gargle
- under normal
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- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 title claims abstract description 30
- 229920000153 Povidone-iodine Polymers 0.000 title claims abstract description 30
- 229960001621 povidone-iodine Drugs 0.000 title claims abstract description 30
- 238000000034 method Methods 0.000 title claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 28
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 19
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229910052740 iodine Inorganic materials 0.000 claims abstract description 16
- 239000011630 iodine Substances 0.000 claims abstract description 16
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 14
- 235000019441 ethanol Nutrition 0.000 claims abstract description 10
- 239000008213 purified water Substances 0.000 claims abstract description 10
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 7
- 229930195725 Mannitol Natural products 0.000 claims abstract description 7
- 235000011187 glycerol Nutrition 0.000 claims abstract description 7
- 239000000594 mannitol Substances 0.000 claims abstract description 7
- 235000010355 mannitol Nutrition 0.000 claims abstract description 7
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims abstract description 7
- 235000019477 peppermint oil Nutrition 0.000 claims abstract description 7
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims abstract description 4
- CTKXFMQHOOWWEB-UHFFFAOYSA-N Ethylene oxide/propylene oxide copolymer Chemical compound CCCOC(C)COCCO CTKXFMQHOOWWEB-UHFFFAOYSA-N 0.000 claims abstract description 4
- -1 gaultherolin Substances 0.000 claims abstract description 4
- 229940044519 poloxamer 188 Drugs 0.000 claims abstract description 4
- 229920001993 poloxamer 188 Polymers 0.000 claims abstract description 4
- 229940085605 saccharin sodium Drugs 0.000 claims abstract description 4
- 239000000243 solution Substances 0.000 claims description 75
- 238000003756 stirring Methods 0.000 claims description 28
- 238000004090 dissolution Methods 0.000 claims description 15
- 239000011259 mixed solution Substances 0.000 claims description 12
- 239000001257 hydrogen Substances 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 2
- 235000015165 citric acid Nutrition 0.000 abstract description 6
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 abstract description 4
- 239000002324 mouth wash Substances 0.000 abstract description 4
- 229940051866 mouthwash Drugs 0.000 abstract description 4
- 208000006558 Dental Calculus Diseases 0.000 abstract description 3
- 206010044029 Tooth deposit Diseases 0.000 abstract description 3
- 238000004040 coloring Methods 0.000 abstract description 3
- 239000004615 ingredient Substances 0.000 abstract description 3
- 230000007794 irritation Effects 0.000 abstract description 3
- 235000013772 propylene glycol Nutrition 0.000 abstract description 3
- 238000004140 cleaning Methods 0.000 abstract description 2
- 230000006870 function Effects 0.000 abstract description 2
- 230000001954 sterilising effect Effects 0.000 abstract description 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 2
- 229940081974 saccharin Drugs 0.000 description 3
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 3
- 235000019204 saccharin Nutrition 0.000 description 3
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 3
- 235000015424 sodium Nutrition 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000726221 Gemma Species 0.000 description 1
- 206010018291 Gingival swelling Diseases 0.000 description 1
- 208000009019 Pericoronitis Diseases 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000028446 budding cell bud growth Effects 0.000 description 1
- 208000020670 canker sore Diseases 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 238000011086 high cleaning Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 235000020995 raw meat Nutrition 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 230000014860 sensory perception of taste Effects 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a kind of I types povidone iodine gargles (0.1% available iodine) and its preparing process, component to be：Povidone iodine, disodium hydrogen phosphate, citric acid, propylene glycol, glycerine, mannitol, saccharin sodium, poloxamer188, ethyl alcohol, water-soluble peppermint oil, gaultherolin, purified water.The present invention is due to having adjusted recipe ingredient and content, and not only irritation is low, has sterilization functions, suitable for various patients, especially to the patient of alcohol sensible, and has cleaning capacity, long-time service will not form dental calculus or facing coloring etc..The present invention rolls into one the advantages of civilian common mouthwash and medical gargle, and abandoned its shortcoming, therefore industry blank has been filled up in the appearance of this product, has extensive market.
Description
Technical field
The present invention relates to curable product technical field, especially a kind of I types povidone iodine gargle (0.1% available iodine) and
Its preparing process.
Background technology
In China, common mouthwash is basically divided into two classes：One kind is civilian common mouthwash, and another kind of is containing drug
Ingredient has the medical gargle of therapeutic effect.The former is disabled in cannot because of the alcoholic content containing 20% even higher concentration
Endure the patient of high concentration ethanol；And also easily initiation dental calculus is formed the latter's long-time service or facing colours and the sense of taste changes.
Invention content
I type povidone iodine gargles low the purpose of the present invention is to provide a kind of irritation and with strong bactericidal effect
(0.1% available iodine) and its preparing process.
The purpose of the present invention is what is realized by following technological means：
A kind of I types povidone iodine gargle (0.1% available iodine), it is characterised in that：Its component and the content of each component are such as
Under：
A kind of preparing process of I types povidone iodine gargle (0.1% available iodine), it is characterised in that：Include the following steps：
(1), stirred evenly with purifying water dissolution povidone iodine under normal temperature condition, formed solution 1；
(2), stirred evenly under normal temperature condition with purified water dissolving phosphoric acid disodium hydrogen, citric acid, propylene glycol, glycerine, until complete
Dissolving forms solution 2；
(3), stirred evenly with purified water dissolving saccharin sodium, mannitol under normal temperature condition, until completely dissolved added solution
Enter into solution 2 and be uniformly mixed, form solution 3；
(4), the purifying water dissolution poloxamer188 for being 45-55 DEG C with temperature, stirs evenly, until completely dissolved by solution
It is added in the mixed solution of solution 3, stirs evenly, form solution 4；
(5), solution 4 is added in solution 1, is stirred evenly, forms solution 5；
(6) water-soluble peppermint oil, gaultherolin, are dissolved with ethyl alcohol under normal temperature condition, after stirring evenly, is added it to
In the mixed solution of solution 5, stir evenly to get to povidone iodine gargle (0.1% available iodine).
The advantages and positive effects of the present invention are：
1st, this povidone iodine gargle is as a kind of novel bactericidal agent containing iodine, to all kinds of bacteriums and its gemma, virus fungi,
Protozoon has stronger killing effect.The product is also equipped with reducing ulcer surface exudation, promotes wound surface convergence speed, promotes new raw meat
The multiple medicinal advantages such as bud growth.Its own property is mild, non-toxic and tasteless no sensitization, and has both high cleaning capability；More because of it
The body-sensings advantages such as low irritant, dye-free coloring reaction to mucous membrane of mouth；Originally directly act on lesion, suitable for gingivitis,
The auxiliary treatment of the diseases such as pericoronitis, oral mucositis, stomatocace, to pharynx rear wall, flat bar body-sensing dye and the upper respiratory tract
The diseases such as infection have therapeutic effect, for oral peculiar smell, canker sore, gum swelling, fragile Susceptible population patient outcome pole
It is good.
2nd, this povidone iodine gargle has strong bactericidal effect, also can effectively dispel tooth because of its professional medicinal formula
And oral cavity dirt, oral peculiar smell is reduced or eliminated, effectively antagonizes air environmental pollution to children, old man or other easy infections crowd
Caused by respiratory disease hidden danger.
3rd, this povidone iodine gargle not spirituosity, it is mild, non-stimulated, suitable for various crowds.
4th, the present invention is due to having adjusted recipe ingredient and content, and not only irritation is low, has sterilization functions, is suitable for
Various patients especially to the patient of alcohol sensible, and have cleaning capacity, and long-time service will not form dental calculus or facing
Coloring etc..The present invention rolls into one the advantages of civilian common mouthwash and medical gargle, and abandoned its shortcoming, therefore this
Industry blank has been filled up in the appearance of product, has extensive market.
Description of the drawings
Fig. 1 is the process flow chart of the present invention.
Specific embodiment
Describe the embodiment of the present invention in detail below in conjunction with the accompanying drawings；It should be noted that the present embodiment is narrative, no
It is limited, it is impossible to which protection scope of the present invention is limited with this.
A kind of I types povidone iodine gargle (0.1% available iodine), the content of component and each component is as follows：
The preparing process of above-mentioned I types povidone iodine gargle (0.1% available iodine), includes the following steps：
(1), stirred evenly with purifying water dissolution povidone iodine under normal temperature condition, formed solution 1；
(2), stirred evenly under normal temperature condition with purified water dissolving phosphoric acid disodium hydrogen, citric acid, propylene glycol, glycerine, until complete
Dissolving forms solution 2；
(3), stirred evenly with purified water dissolving saccharin sodium, mannitol under normal temperature condition, until completely dissolved added solution
Enter into solution 2 and be uniformly mixed, form solution 3；
(4), the purifying water dissolution poloxamer188 for being 45-55 DEG C with temperature, stirs evenly, until completely dissolved by solution
It is added in the mixed solution of solution 3, stirs evenly, form solution 4；
(5), solution 4 is added in solution 1, is stirred evenly, forms solution 5；
(6) water-soluble peppermint oil, gaultherolin, are dissolved with ethyl alcohol under normal temperature condition, after stirring evenly, is added it to
In the mixed solution of solution 5, stir evenly to get to povidone iodine gargle (0.1% available iodine).
Several embodiments are enumerated below, I type povidone iodine gargle (0.1% available iodine) and its preparation process are carried out detailed
It describes in detail bright.
Embodiment one
A kind of preparing process of I types povidone iodine gargle (0.1% available iodine), includes the following steps：
(1), purify water dissolution 9.5g povidone iodine with 200g under normal temperature condition, stir evenly, form solution 1；
(2), under normal temperature condition with 100g purify water dissolution 8.5g disodium hydrogen phosphates, 4.5g citric acids, 4.5g propylene glycol,
4.5g glycerine stirs evenly, until being completely dissolved, forms solution 2；
(3), purify water dissolution 0.2g saccharin sodiums, 35g mannitol with 350.8g under normal temperature condition, stir evenly, treat completely molten
Solution is added in solution 2 and is uniformly mixed after solution, forms solution 3；
(4), the purified water 200g for being 45-55 DEG C with temperature dissolves 1g poloxamer188s, stirs evenly, until completely dissolved
Solution is added in the mixed solution of solution 3, stirred evenly, form solution 4；
(5), solution 4 is added in solution 1, is stirred evenly, forms solution 5；
It (6), will after stirring evenly, with 80g ethyl alcohol dissolving 1g water solubilitys peppermint oil, 0.5g gaultherolins under normal temperature condition
It is added in the mixed solution of solution 5, is stirred evenly to get to 1 kilogram of povidone iodine gargle (0.1% available iodine).
Embodiment two
A kind of preparing process of I types povidone iodine gargle (0.1% available iodine), includes the following steps：
(1), purify water dissolution 11g povidone iodine with 200g under normal temperature condition, stir evenly, form solution 1；
(2), purify water dissolution 9g disodium hydrogen phosphates, 5g citric acids, 5g propylene glycol, 5g glycerine with 100g under normal temperature condition to stir
It mixes uniformly, until being completely dissolved, forms solution 2；
(3), purify water dissolution 0.5g saccharin sodiums, 40g mannitol with 319.5g under normal temperature condition, stir evenly, treat completely molten
Solution is added in solution 2 and is uniformly mixed after solution, forms solution 3；
(4), the purified water 200g for being 45-55 DEG C with temperature dissolves 2g poloxamer188s, stirs evenly, until completely dissolved
Solution is added in the mixed solution of solution 3, stirred evenly, form solution 4；
(5), solution 4 is added in solution 1, is stirred evenly, forms solution 5；
It (6), will after stirring evenly, with 100g ethyl alcohol dissolving 2g water solubilitys peppermint oil, 1g gaultherolins under normal temperature condition
It is added in the mixed solution of solution 5, is stirred evenly to get to 1 kilogram of povidone iodine gargle (0.1% available iodine).
Embodiment three
(1), purify water dissolution 12g povidone iodine with 200g under normal temperature condition, stir evenly, form solution 1；
(2), purify water dissolution 10g disodium hydrogen phosphates, 6g citric acids, 6g propylene glycol, 6g glycerine with 100g under normal temperature condition to stir
It mixes uniformly, until being completely dissolved, forms solution 2；
(3), purify water dissolution 1g saccharin sodiums, 45g mannitol with 292.5g under normal temperature condition, stir evenly, wait to be completely dissolved
Solution is added in solution 2 and is uniformly mixed afterwards, forms solution 3；
(4), the purified water 200g for being 45-55 DEG C with temperature dissolves 5g poloxamer188s, stirs evenly, until completely dissolved
Solution is added in the mixed solution of solution 3, stirred evenly, form solution 4；
(5), solution 4 is added in solution 1, is stirred evenly, forms solution 5；
(6), 5g water solubilitys peppermint oil, 1.5g gaultherolins are dissolved with 110g ethyl alcohol under normal temperature condition, after stirring evenly,
It adds it in the mixed solution of solution 5, stirs evenly to get to 1 kilogram of povidone iodine gargle (0.1% available iodine).
Claims (1)
1. a kind of I types povidone iodine gargle, which includes 0.1% available iodine, it is characterised in that：Its component and each component
Content it is as follows：
The preparing process of above-mentioned I types povidone iodine gargle, includes the following steps：
(1), stirred evenly with purifying water dissolution povidone iodine under normal temperature condition, formed solution 1；
(2), stirred evenly under normal temperature condition with purified water dissolving phosphoric acid disodium hydrogen, citric acid, propylene glycol, glycerine, until completely molten
Solution forms solution 2；
(3), stirred evenly with purified water dissolving saccharin sodium, mannitol under normal temperature condition, be until completely dissolved added to solution
It in solution 2 and is uniformly mixed, forms solution 3；
(4), the purifying water dissolution poloxamer188 for being 45-55 DEG C with temperature, stirs evenly, until completely dissolved adds in solution
It into the mixed solution of solution 3, stirs evenly, forms solution 4；
(5), solution 4 is added in solution 1, is stirred evenly, forms solution 5；
(6) water-soluble peppermint oil, gaultherolin, are dissolved with ethyl alcohol under normal temperature condition, after stirring evenly, adds it to solution 5
Mixed solution in, stir evenly to get to the povidone iodine gargle comprising 0.1% available iodine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510340407.3A CN105030818B (en) | 2015-06-18 | 2015-06-18 | A kind of I types povidone iodine gargle and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510340407.3A CN105030818B (en) | 2015-06-18 | 2015-06-18 | A kind of I types povidone iodine gargle and its preparing process |
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| Publication Number | Publication Date |
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| CN105030818A CN105030818A (en) | 2015-11-11 |
| CN105030818B true CN105030818B (en) | 2018-07-03 |
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| CN201510340407.3A Expired - Fee Related CN105030818B (en) | 2015-06-18 | 2015-06-18 | A kind of I types povidone iodine gargle and its preparing process |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109512683B (en) * | 2018-12-14 | 2021-06-15 | 上海融澈水性材料有限公司 | Povidone-iodine composition and preparation method and application thereof |
| CN110037940A (en) * | 2019-05-22 | 2019-07-23 | 浙江欧洁科技股份有限公司 | A kind of sterilizing oral disinfection mouthwash and preparation method thereof and application method |
| CN115501141A (en) * | 2022-10-21 | 2022-12-23 | 深圳市安杏舒电子商务有限公司 | Tooth brushing water and preparation method and use method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102475679A (en) * | 2010-11-24 | 2012-05-30 | 江苏省勤奋药业有限公司 | 10% povidone iodine solution |
-
2015
- 2015-06-18 CN CN201510340407.3A patent/CN105030818B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102475679A (en) * | 2010-11-24 | 2012-05-30 | 江苏省勤奋药业有限公司 | 10% povidone iodine solution |
Non-Patent Citations (1)
| Title |
|---|
| 聚维酮碘漱口液抑制菌斑的作用;王渠蔓等;《北京口腔医学》;20001231;第8卷(第3期);116-118 * |
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| CN105030818A (en) | 2015-11-11 |
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