CN104887623A - Type II povidone-iodine gargle containing 0.1% of available iodine and preparation process of type II povidone-iodine gargle - Google Patents
Type II povidone-iodine gargle containing 0.1% of available iodine and preparation process of type II povidone-iodine gargle Download PDFInfo
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- CN104887623A CN104887623A CN201510341837.7A CN201510341837A CN104887623A CN 104887623 A CN104887623 A CN 104887623A CN 201510341837 A CN201510341837 A CN 201510341837A CN 104887623 A CN104887623 A CN 104887623A
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- solution
- iodine
- povidone
- type
- gargle
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- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 title claims abstract description 36
- 229920000153 Povidone-iodine Polymers 0.000 title claims abstract description 36
- 229960001621 povidone-iodine Drugs 0.000 title claims abstract description 36
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 title claims abstract description 22
- 229910052740 iodine Inorganic materials 0.000 title claims abstract description 22
- 239000011630 iodine Substances 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 28
- 239000008213 purified water Substances 0.000 claims abstract description 25
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 21
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 21
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 20
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims abstract description 7
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 7
- XINCECQTMHSORG-UHFFFAOYSA-N Isoamyl isovalerate Chemical compound CC(C)CCOC(=O)CC(C)C XINCECQTMHSORG-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229930195725 Mannitol Natural products 0.000 claims abstract description 7
- 239000000594 mannitol Substances 0.000 claims abstract description 7
- 235000010355 mannitol Nutrition 0.000 claims abstract description 7
- 229940085605 saccharin sodium Drugs 0.000 claims abstract description 7
- 239000000243 solution Substances 0.000 claims description 72
- 238000003756 stirring Methods 0.000 claims description 42
- 239000011259 mixed solution Substances 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 10
- 241000581835 Monodora junodii Species 0.000 claims description 7
- CTKXFMQHOOWWEB-UHFFFAOYSA-N Ethylene oxide/propylene oxide copolymer Chemical compound CCCOC(C)COCCO CTKXFMQHOOWWEB-UHFFFAOYSA-N 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 229940044519 poloxamer 188 Drugs 0.000 claims description 6
- 229920001993 poloxamer 188 Polymers 0.000 claims description 6
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 3
- 239000001257 hydrogen Substances 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- -1 phosphoric acid disodium hydrogen Chemical class 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 13
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 abstract description 4
- 229910000397 disodium phosphate Inorganic materials 0.000 abstract description 4
- 235000019800 disodium phosphate Nutrition 0.000 abstract description 4
- 208000006558 Dental Calculus Diseases 0.000 abstract description 3
- 238000004140 cleaning Methods 0.000 abstract description 2
- 238000004040 coloring Methods 0.000 abstract description 2
- 230000001954 sterilising effect Effects 0.000 abstract description 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 2
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 abstract 1
- 235000015165 citric acid Nutrition 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 230000007794 irritation Effects 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 abstract 1
- 239000002324 mouth wash Substances 0.000 abstract 1
- 229940051866 mouthwash Drugs 0.000 abstract 1
- 235000019477 peppermint oil Nutrition 0.000 abstract 1
- 229920001992 poloxamer 407 Polymers 0.000 abstract 1
- 229940044476 poloxamer 407 Drugs 0.000 abstract 1
- 235000013772 propylene glycol Nutrition 0.000 abstract 1
- 206010006326 Breath odour Diseases 0.000 description 2
- 208000032139 Halitosis Diseases 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 241000233866 Fungi Species 0.000 description 1
- 208000007117 Oral Ulcer Diseases 0.000 description 1
- 208000009019 Pericoronitis Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000003139 biocide Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 230000014860 sensory perception of taste Effects 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to type II povidone-iodine gargle containing 0.1% of available iodine and a preparation process of the type II povidone-iodine gargle. The type II povidone-iodine gargle comprises the following components: povidone-iodine, sodium hydrogen phosphate, citric acid, propylene glycol, glycerin, mannitol, saccharin sodium, poloxamer 407, ethanol, water-soluble peppermint oil, apple essence and purified water. The formula components and content are adjusted, so that the type II povidone-iodine gargle is low in irritation, has a sterilization function, is suitable for various patients especially ethanol sensitive patients, and has cleaning capacity, and tartar or dental face coloring and the like cannot be formed after long-term use. Advantages of common mouthwash for civil use and a medical gargle are integrated, and disadvantages are abandoned, so that the type II povidone-iodine gargle fills up the industrial blank and has broad market.
Description
Technical field
The present invention relates to curable product technical field, especially a kind of II type povidone iodine gargarism (0.1% available iodine) and preparing process thereof.
Background technology
In China, common collutory can be divided into two classes substantially: a class is civilian common collutory, the another kind of medical gargarism for having therapeutic effect containing drug ingredient.The former, because of containing the 20% even alcoholic content of higher concentration, forbids the patient in being impatient at high concentration ethanol; And the latter's life-time service also easily causes tartar formation, or facing is painted and the sense of taste changes.
Summary of the invention
The object of the present invention is to provide a kind of zest low and there is II type povidone iodine gargarism (0.1% available iodine) and the preparing process thereof of strong bactericidal effect.
The object of the invention is to be realized by following technological means:
A kind of II type povidone iodine gargarism (0.1% available iodine), is characterized in that: the content of its component and each component is as follows:
A kind of preparing process of II type povidone iodine gargarism (0.1% available iodine), is characterized in that: comprise the following steps:
(1), dissolve povidone iodine by purified water under normal temperature condition, stir, form solution 1;
(2), stirring with purified water dissolving phosphoric acid disodium hydrogen, citric acid, propylene glycol, glycerol under normal temperature condition, to dissolving completely, forming solution 2;
(3), dissolve saccharin sodium, mannitol by purified water under normal temperature condition, stir, until completely dissolved solution to be joined in solution 2 and mix homogeneously, form solution 3;
(4), by temperature be the purified water dissolving poloxamer188 of 45-55 DEG C, stir, until completely dissolved solution is joined in the mixed solution of solution 3, stir, form solution 4.
(5), by solution 4 join in solution 1, stir, form solution 5;
, under normal temperature condition with dissolve with ethanol water solublity Oleum menthae, green apple essence, after stirring, joined in the mixed solution of solution 5, stirred, namely obtained povidone iodine gargarism (0.1% available iodine).
Advantage of the present invention and good effect are:
1, this povidone iodine gargarism is novel containing iodine biocide as one, all has stronger killing action to each bacterioid and spore thereof, viral fungus, protozoon.This product also possesses minimizing ulcer surface and oozes out, promotes wound surface convergence speed, promotes newly to granulate the multiple medicinal advantages such as growth.Himself character is gentle, nonpoisonous and tasteless without sensitization, and has abrasive ability concurrently; More because of body sense advantages such as its low irritant to oral mucosa, dye-free coloring reactions; Originally focus is directly acted on, be applicable to the auxiliary treatment of the diseases such as gingivitis, pericoronitis, oral mucositis, stomatocace, to pharynx rear wall, flat bar body infects and upper respiratory tract infection all has therapeutic effect, splendid for halitosis, oral ulcer, swelling and aching of gum, fragile Susceptible population patient outcome.
2, this povidone iodine gargarism is because of its professional medicinal formula, there is strong bactericidal effect, also effectively can dispel tooth and oral cavity dirt, reduce or eliminate halitosis, effectively resist the respiratory system disease hidden danger that air environmental pollution causes child, old man or other easy infections crowd.
3, this povidone iodine gargarism is soft, gentle, non-stimulated, is applicable to various crowd.
4, this product is green apple taste, uses rear breath freshening, is especially applicable to the taste of youngster and child.
5, the present invention is owing to have adjusted recipe ingredient and content, and therefore not only zest is low, has sterilization functions, is applicable to various patient, especially to the patient of alcohol sensible, and has cleaning capacity, life-time service can not form tartar or facing painted etc.The advantage of civilian common collutory and medical gargarism rolls into one by the present invention, and has abandoned its shortcoming, and therefore industry blank has been filled up in the appearance of this product, has market widely.
Accompanying drawing explanation
Fig. 1 is process chart of the present invention.
Detailed description of the invention
Embodiments of the invention are described in detail below in conjunction with accompanying drawing; It should be noted that, the present embodiment is narrative, is not determinate, can not limit protection scope of the present invention with this.
A kind of II type povidone iodine gargarism (0.1% available iodine), the content of its component and each component is as follows:
The preparing process of above-mentioned II type povidone iodine gargarism (0.1% available iodine), comprises the following steps:
(1), dissolve povidone iodine by purified water under normal temperature condition, stir, form solution 1;
(2), stirring with purified water dissolving phosphoric acid disodium hydrogen, citric acid, propylene glycol, glycerol under normal temperature condition, to dissolving completely, forming solution 2;
(3), dissolve saccharin sodium, mannitol by purified water under normal temperature condition, stir, until completely dissolved solution to be joined in solution 2 and mix homogeneously, form solution 3;
(4), by temperature be the purified water dissolving poloxamer188 of 45-55 DEG C, stir, until completely dissolved solution is joined in the mixed solution of solution 3, stir, form solution 4.
(5), by solution 4 join in solution 1, stir, form solution 5;
, under normal temperature condition with dissolve with ethanol water solublity Oleum menthae, green apple essence, after stirring, joined in the mixed solution of solution 5, stirred, namely obtained povidone iodine gargarism (0.1% available iodine).
Below enumerate several embodiment, II type povidone iodine gargarism (0.1% available iodine) and preparation technology thereof are described in detail.
Embodiment one
A kind of preparing process of II type povidone iodine gargarism (0.1% available iodine), comprises the following steps:
(1), under normal temperature condition dissolve 9.5g povidone iodine by 200g purified water, stir, form solution 1;
(2), under normal temperature condition with 100g purified water dissolve 8.5g sodium hydrogen phosphate, 4.5g citric acid, 4.5g propylene glycol, 4.5g glycerol stirs, and to dissolving completely, forms solution 2;
(3), under normal temperature condition dissolve 0.5g saccharin sodium, 35g mannitol by 381.5g purified water, stir, until completely dissolved solution to be joined in solution 2 and mix homogeneously, form solution 3;
(4), by temperature be the purified water 200g dissolving 1g poloxamer188 of 45-55 DEG C, stir, until completely dissolved solution is joined in the mixed solution of solution 3, stir, form solution 4.
(5), by solution 4 join in solution 1, stir, form solution 5;
, under normal temperature condition with 45g dissolve with ethanol 1g water solublity Oleum menthae, 4.5g green apple essence, after stirring, joined in the mixed solution of solution 5, stirred, namely obtained 1 kilogram of povidone iodine gargarism (0.1% available iodine).
Embodiment two
A kind of preparing process of II type povidone iodine gargarism (0.1% available iodine), comprises the following steps:
(1), under normal temperature condition dissolve 11g povidone iodine by 200g purified water, stir, form solution 1;
(2), under normal temperature condition with 100g purified water dissolve 9g sodium hydrogen phosphate, 5g citric acid, 5g propylene glycol, 5g glycerol stirs, and to dissolving completely, forms solution 2;
(3), under normal temperature condition dissolve 0.1g saccharin sodium, 40g mannitol by 363.9g purified water, stir, until completely dissolved solution to be joined in solution 2 and mix homogeneously, form solution 3;
(4), by temperature be the purified water 200g dissolving 3g poloxamer188 of 45-55 DEG C, stir, until completely dissolved solution is joined in the mixed solution of solution 3, stir, form solution 4.
(5), by solution 4 join in solution 1, stir, form solution 5;
, under normal temperature condition with 50g dissolve with ethanol 3g water solublity Oleum menthae, 5g green apple essence, after stirring, joined in the mixed solution of solution 5, stirred, namely obtained 1 kilogram of povidone iodine gargarism (0.1% available iodine).
Embodiment three
A kind of preparing process of II type povidone iodine gargarism (0.1% available iodine), comprises the following steps:
(1), under normal temperature condition dissolve 12g povidone iodine by 200g purified water, stir, form solution 1;
(2), under normal temperature condition with 100g purified water dissolve 10g sodium hydrogen phosphate, 6g citric acid, 6g propylene glycol, 6g glycerol stirs, and to dissolving completely, forms solution 2;
(3), under normal temperature condition dissolve 10g saccharin sodium, 45g mannitol by 329g purified water, stir, until completely dissolved solution to be joined in solution 2 and mix homogeneously, form solution 3;
(4), by temperature be the purified water 200g dissolving 5g poloxamer188 of 45-55 DEG C, stir, until completely dissolved solution is joined in the mixed solution of solution 3, stir, form solution 4.
(5), by solution 4 join in solution 1, stir, form solution 5;
, under normal temperature condition with 60g dissolve with ethanol 5g water solublity Oleum menthae, 6g green apple essence, after stirring, joined in the mixed solution of solution 5, stirred, namely obtained 1 kilogram of povidone iodine gargarism (0.1% available iodine).
Claims (2)
1. an II type povidone iodine gargarism (0.1% available iodine), is characterized in that: the content of its component and each component is as follows:
2. a preparing process for II type povidone iodine gargarism (0.1% available iodine) as claimed in claim 1, is characterized in that: comprise the following steps:
(1), dissolve povidone iodine by purified water under normal temperature condition, stir, form solution 1;
(2), stirring with purified water dissolving phosphoric acid disodium hydrogen, citric acid, propylene glycol, glycerol under normal temperature condition, to dissolving completely, forming solution 2;
(3), dissolve saccharin sodium, mannitol by purified water under normal temperature condition, stir, until completely dissolved solution to be joined in solution 2 and mix homogeneously, form solution 3;
(4), by temperature be the purified water dissolving poloxamer188 of 45-55 DEG C, stir, until completely dissolved solution is joined in the mixed solution of solution 3, stir, form solution 4.
(5), by solution 4 join in solution 1, stir, form solution 5;
, under normal temperature condition with dissolve with ethanol water solublity Oleum menthae, green apple essence, after stirring, joined in the mixed solution of solution 5, stirred, namely obtained povidone iodine gargarism (0.1% available iodine).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510341837.7A CN104887623B (en) | 2015-06-18 | 2015-06-18 | A kind of II types povidone iodine gargle |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510341837.7A CN104887623B (en) | 2015-06-18 | 2015-06-18 | A kind of II types povidone iodine gargle |
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| Publication Number | Publication Date |
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| CN104887623A true CN104887623A (en) | 2015-09-09 |
| CN104887623B CN104887623B (en) | 2018-05-08 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510341837.7A Expired - Fee Related CN104887623B (en) | 2015-06-18 | 2015-06-18 | A kind of II types povidone iodine gargle |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109512683A (en) * | 2018-12-14 | 2019-03-26 | 上海融澈水性材料有限公司 | A kind of povidone iodine composition and the preparation method and application thereof |
| CN110037940A (en) * | 2019-05-22 | 2019-07-23 | 浙江欧洁科技股份有限公司 | A kind of sterilizing oral disinfection mouthwash and preparation method thereof and application method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102475679A (en) * | 2010-11-24 | 2012-05-30 | 江苏省勤奋药业有限公司 | 10% povidone iodine solution |
-
2015
- 2015-06-18 CN CN201510341837.7A patent/CN104887623B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102475679A (en) * | 2010-11-24 | 2012-05-30 | 江苏省勤奋药业有限公司 | 10% povidone iodine solution |
Non-Patent Citations (3)
| Title |
|---|
| 张英等: "《精品化学品配方大全》", 31 May 2001, 化学工业出版社 * |
| 王渠蔓等: "聚维酮碘漱口液抑制菌斑的作用", 《北京口腔医学》 * |
| 谢明勇等: "《日用化学品实用生产技术与配方》", 30 June 2002 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109512683A (en) * | 2018-12-14 | 2019-03-26 | 上海融澈水性材料有限公司 | A kind of povidone iodine composition and the preparation method and application thereof |
| CN109512683B (en) * | 2018-12-14 | 2021-06-15 | 上海融澈水性材料有限公司 | Povidone-iodine composition and preparation method and application thereof |
| CN110037940A (en) * | 2019-05-22 | 2019-07-23 | 浙江欧洁科技股份有限公司 | A kind of sterilizing oral disinfection mouthwash and preparation method thereof and application method |
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| Publication number | Publication date |
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| CN104887623B (en) | 2018-05-08 |
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