CN106620673A - Hydrogel for treating infant dental ulcer and preparation method of hydrogel - Google Patents
Hydrogel for treating infant dental ulcer and preparation method of hydrogel Download PDFInfo
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- CN106620673A CN106620673A CN201611254353.XA CN201611254353A CN106620673A CN 106620673 A CN106620673 A CN 106620673A CN 201611254353 A CN201611254353 A CN 201611254353A CN 106620673 A CN106620673 A CN 106620673A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
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- A61K31/7135—Compounds containing heavy metals
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
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Abstract
The invention belongs to the field of medicine, and provides a hydrogel for treating infant dental ulcer and a preparation method of the hydrogel. The hydrogel consists of the following components: a mussel soft tissue extract, trypsin, honey, vitamin C, vitamin B1, vitamin B2, nicotinamide, vitamin B12, water-soluble menthol and a gel substrate. The hydrogel prepared by the invention is mainly applicable to local virus resistance, sterilization, inflammation diminishing and pain alleviating of a wound surface with the infant dental ulcer, and the hydrogel is capable of promoting the healing of the wound surface of the dental ulcer, so that a dental ulcer treating medicine, which is good in curative effect, rapid to take effects, durable in effect, free from dependency and free from toxic and side effects, is offered to broad infant patents.
Description
Technical field
The invention belongs to medical field, more particularly to a kind of hydrogel for treating dental ulcer of infant and its preparation side
Method.
Background technology
Dental ulcer of infant (also known as " aphtha ") is a kind of modal oral keritonocytes, illness rate one in children group
As think more than 10%.Dental ulcer of infant is that a kind of mucous membrane of mouth limitation ulcer with the characteristics of periodic flare is damaged
Evil, it is seen that in the children at any age, but it is more to be fallen ill with infant.Dental ulcer of infant includes thrush, herpes simplex
Property aphtha, exedens aphtha.Thrush is the invasion and attack due to there is Candida albicans, forms thrush.In the early stage in buccal mucosa,
There are point-like and strip to consider to be worth doing in vain at tongue, gums, maxilla, and be gradually fused into sheet, be difficult to wipe away.Herpes simplex aphtha be
Occur slight bright folliculus on the mucous membrane of oral cavity, tongue and congestion of throat, shortly diabrosis quickly, form ulcer.Cervical lymph
Also accordingly there is enlargement in knot, there is tenderness.Exedens aphtha is that various coccuses often invade infant, causes stomatitis, oral mucosa
There is obvious hyperemia, with the ulcer for differing in size, have linen pseudomembrane to cover in ulcer, children's very pain, salivation is not
Only, have the fidgets, refusal feed is often accompanied by heating and cervical lymph node enlargement.
Existing medicine for treating oral cavity ulcer composition mostly containing hormone such as dexamethasone etc., is not suitable for infant and children.
Though in a short time curative effect is obvious for hormone medicine, Long-Time Service can produce very big side effect, and patient uses hormone in clinical observation
Easily cause Relapse rate.Current medicine for treating oral cavity ulcer its analgesic effect relies primarily on the anaesthetic of addition, such as local anesthetic
Thing totokaine etc., its anaesthetic effect is of short duration, may simultaneously anaesthetize lip, cheek or tongue, is easily caused children and bites and may cause tight
Weight allergy.And existing medicine for treating oral cavity ulcer is mostly tablet, spray etc., length is difficult when acting on ulcer surface in irregular shape
Phase keeps playing often has saliva stop to reduce topically effective drug concentration in curative effect, and oral cavity, additionally, existing preparation formulation
Little childhood is being applied to, can often cause children to contradict.
Mussel (Mytilus edulis Linnaeus) is a kind of sea mollusk, belongs to bivalve shellfish, is commonly called as " blue or green
Mouthful " and " mussel ", each coastwise contries of throughout world.Mussel species are various, and only coastal area of china just has kind more than 30, and economic worth is higher
Have kind more than 10, wherein Mytilus galloprovincialis, Perna viridis and Trachyostracous mussel is main breed variety.Enriched Mussel containing protein, fat,
The nutrients such as carbohydrate, calcium, phosphorus, iron, riboflavin, niacin, and with very high medical value.
Trypsase (Trypsin, Parenzyme), EC 3.4.21.4 are the one kind extracted from the pancreas of ox, sheep, pig
Serine protein hydrolase.The precursor trypsinogen of pancreas manufacture is secreted into after small intestine, and erepsin activates it, becomes pancreas egg
White enzyme.Trypsase is endopeptidase, the carboxyl that it can optionally in the lysine and arginine residues of hydrolyzed peptide chain.
Trypsase not only plays digestive ferment, and can also limit decomposition chymotrypsinogen, procarboxypeptidase, phosphatide proenzyme etc. other
The precursor of enzyme, plays activation.
The content of the invention
It is unsuitable for children, easily causes that ulcer recurrence, anaesthetic effect be short, side effect containing hormone for solves that existing medicine is present
Greatly, DeGrain, drug effect keep the defect such as not lasting, and present invention proposition is a kind of to be particularly suitable for treating dental ulcer of infant
Hydrogel, is mainly used in topical antiviral, sterilization, anti-inflammatory, the pain relieving of the canker sore surface of a wound, promotes healing for the canker sore surface of a wound
Close, for vast pediatric patient provide good effect, instant effect, persistent, without rely on, have no toxic side effect canker sore use
Medicine.
For achieving the above object, the present invention proposes a kind of hydrogel for treating dental ulcer of infant, it is characterised in that include
It is mussel soft tissue extract, trypsase, honey, vitamin, vitamin B1, vitamin B2, niacinamide, vitamin B12, water-soluble
Property menthol and gel-type vehicle.
One or more aspects of the invention, the hydrogel of the treatment dental ulcer of infant, by gross weight meter：Make a gift of
Shellfish soft tissue extract 0.1-15 parts, trypsase 0.1-20 parts, honey 0.1-10 parts, vitamin C 0.1-5 parts, vitamin B1
0.1-5 parts, vitamin B2 0.1-5 parts, niacinamide 0.1-1 parts, vitamin B12 0.1-1 parts, water-soluble menthol 0.1-5 parts,
Gel-type vehicle.By gross weight meter：Mussel soft tissue extract is such as 0.1 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5
Part, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts, 10 parts, 10.5 parts, 11
Part, 11.5 parts, 12 parts, 12.5 parts, 13 parts, 13.5 parts, 14 parts, 14.5 parts, 15 parts etc., trypsase is such as 0.1 part, 0.2
Part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts,
8.5 parts, 9 parts, 9.5 parts, 10 parts, 10.5 parts, 11 parts, 11.5 parts, 12 parts, 12.5 parts, 13 parts, 13.5 parts, 14 parts, 14.5 parts,
15 parts, 15.5 parts, 16 parts, 16.5 parts, 17 parts, 17.5 parts, 18 parts, 18.5 parts, 19 parts, 19.5 parts, 20 parts etc., honey is for example
0.1 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8
Part, 8.5 parts, 9 parts, 9.5 parts, 10 parts etc., vitamin C is such as 0.1 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4
Part, 4.5 parts, 5 parts etc., vitamin B1 is such as 0.1 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5
Part etc., vitamin B2 is such as 0.1 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts etc., niacinamide
It it is such as 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part etc., vitamin B12 is
Such as 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part etc., water-soluble menthol
It is such as 0.1 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts etc., and appropriate gel-type vehicle.
One or more aspects of the invention, the hydrogel of the treatment dental ulcer of infant can also contain plant
Extract.
One or more aspects of the invention, plant extracts contained by the hydrogel of the treatment dental ulcer of infant
One or more in grape seed extract, Punica granatum L. extract, apple extract etc..
One or more aspects of the invention, the hydrogel of the treatment dental ulcer of infant can be added further
Auxiliary material, the auxiliary material can be antioxidant, bacteriostatic agent, essence or host material etc.；Or the composition is further included
Pharmaceutically acceptable carrier, such as solvent, salt, decentralized medium, coating material, surfactant, antioxidant, preservative
(such as antiseptic, antifungal agent), isotonic agent, absorption delaying agent, drug stabilizing agent, adhesive, excipient, disintegrant, lubrication
Agent, sweetener, flavouring, dyestuff etc. and combination a kind of, various or whole in them.
One or more aspects of the invention, in the hydrogel of the treatment dental ulcer of infant：Mussel soft tissue
Extract, trypsase can be dry powder.
One or more aspects of the invention, in the hydrogel of the treatment dental ulcer of infant：Mussel soft tissue
Extract, trypsase can be liquid.
One or more aspects of the invention, the final ph of the hydrogel of the treatment dental ulcer of infant can be with
For 3.8-5.8, e.g. 4.5-5.5.
One or more aspects of the invention, the mussel soft tissue extract is all in addition to shell with mussel
Component is raw material, and the supernatant for extracting through acidic aqueous solution and obtaining, wherein protein content are 0.2-15.0mg/ml, pH
Value 1.0-6.0.Especially, can be with byssus as raw material.
One or more aspects of the invention, the mussel can include Mytilus galloprovincialis, Perna viridis and Trachyostracous mussel
In one kind, two or three.
One or more embodiments of the invention, the acidic aqueous solution can include：Acetic acid-acetate buffer
Liquid, acetic acid, citric acid, perchloric acid etc., but not limited to this.
One or more embodiments of the invention, the protein content of the mussel soft tissue extract can be
Such as 0.2mg/ml, 0.3mg/ml, 0.4mg/ml, 0.5mg/ml, 0.6mg/ml, 0.7mg/ml, 0.8mg/ml, 0.9mg/ml,
1.0mg/ml、1.5mg/ml、2.0mg/ml、2.5mg/ml、3.0mg/ml、3.5mg/ml、4.0mg/ml、4.5mg/ml、
5.0mg/ml、5.5mg/ml、6.0mg/ml、6.5mg/ml、7.0mg/ml、7.5mg/ml、8.0mg/ml、8.5mg/ml、
9.0mg/ml、9.5mg/ml、10.0mg/ml、10.5mg/ml、11.0mg/ml、11.5mg/ml、12.0mg/ml、12.5mg/
Ml, 13.0mg/ml, 13.5mg/ml, 14.0mg/ml, 14.5mg/ml and 15.0mg/ml etc., but not limited to this.
One or more aspects of the invention, the trypsase can be conventional purchase from the market.Substitute
Ground, the trypsase can be by saltouing, it is prepared by the method such as column chromatography.
The hydrogel for the treatment of dental ulcer of infant of the invention is mainly used in the local of the dental ulcer of infant surface of a wound and resists
Virus, sterilization, anti-inflammatory, pain relieving, promote the healing of the canker sore surface of a wound, and it can especially act on infant thrush, pure blister
Rash aphtha, exedens aphtha, and gel preparations convenient drug administration, the lasting medicine of the present invention, provide for vast pediatric patient
Good effect, instant effect, persistent, without the canker sore medication for relying on, having no toxic side effect.
Additionally, the present invention also proposes a kind of hydrogel for treating dental ulcer of infant, containing mussel soft tissue extract, pancreas
Protease, honey, vitamin, vitamin B1, vitamin B2, niacinamide, vitamin B12, water-soluble menthol and gel base
Matter, optionally, can also commonly use or acceptable auxiliary material containing other field of medicaments.
One or more aspects of the invention, to experimenter in need hydrogel of the invention, institute are given
State hydrogel and contain mussel soft tissue extract, trypsase, honey, vitamin, vitamin B1, vitamin B2, niacinamide, dimension
Raw element B12, water-soluble menthol and gel-type vehicle.
One or more embodiments of the invention, the mussel soft tissue extract, trypsase, honey, dimension
Raw element, vitamin B1, vitamin B2, niacinamide, vitamin B12, water solubility menthol and gel-type vehicle be mixed in
In composition.
In one aspect of the invention, a kind of hydrogel for treating dental ulcer of infant, including：
Mussel soft tissue extract 0.1-15 parts,
Trypsase 0.1-20 parts,
Honey 0.1-10 parts,
Vitamin C 0.1-5 parts,
Vitamin B1 0.1-5 parts,
Vitamin B2 0.1-5 parts,
Niacinamide 0.1-1 parts,
Vitamin B12 0.1-1 parts,
Water-soluble menthol 0.1-5 parts,
Gel-type vehicle, and
Grape seed extract.
In one aspect of the invention, a kind of hydrogel for treating dental ulcer of infant, including：
Mussel soft tissue extract 0.1-15 parts,
Trypsase 0.1-20 parts,
Honey 0.1-10 parts,
Vitamin C 0.1-5 parts,
Vitamin B1 0.1-5 parts,
Vitamin B2 0.1-5 parts,
Niacinamide 0.1-1 parts,
Vitamin B12 0.1-1 parts,
Water-soluble menthol 0.1-5 parts,
Gel-type vehicle, and
Punica granatum L. extract 0.1-5 parts.
In one aspect of the invention, a kind of hydrogel for treating dental ulcer of infant, including：
Mussel soft tissue extract 0.1-15 parts,
Trypsase 0.1-20 parts,
Honey 0.1-10 parts,
Vitamin C 0.1-5 parts,
Vitamin B1 0.1-5 parts,
Vitamin B2 0.1-5 parts,
Niacinamide 0.1-1 parts,
Vitamin B12 0.1-1 parts,
Water-soluble menthol 0.1-5 parts,
Gel-type vehicle, and
Apple extract 0.1-5 parts.
Additionally, the invention allows for a kind of method prepared for treating the hydrogel of dental ulcer of infant, including step
Suddenly：
1) gel-type vehicle is dissolved in suitable quantity of water makes it fully swelling, adjusts pH value to 4.0-5.0；
2) by mussel soft tissue extract, trypsase, honey, vitamin C, vitamin B1, vitamin B2, niacinamide,
Vitamin B12, water-soluble menthol are dissolved in suitable quantity of water, stirring and dissolving；
3) by step 2) solution be added to step 1) in swelling good gel-type vehicle, stir；
4) by sweetener and the water stirring and dissolving of remaining recipe quantity, add step 3) matrix in, stir and evenly mix, by specification
Packing obtains hydrogel.
Following examples are illustrated by taking the hydrogel for treating dental ulcer of infant as an example, but not limited to this, and above-mentioned is sent out
Bright proposition it is various comprising mussel soft tissue extract, trypsase, honey, vitamin, vitamin B1, vitamin B2, nicotinoyl
Amine, vitamin B12, water-soluble menthol, the hydrogel of gel-type vehicle are applied to the present invention.
Specific embodiment
Embodiment 1：A kind of preparation method of mussel soft tissue extract
Take mussel to shell, collect soft tissue 300g, be divided into three parts, per part adds the following table acidity of 100ml contents 0.3% molten
Liquid, centrifugation after homogenate 10min obtains supernatant and is mussel soft tissue extract.
Protein content and pH value in supernatant is determined, determining the protein quantity adopts Coomassie Brilliant Blue.
Table 1
| Example | Acid solution | Protein content | PH value |
| 1 | Citric acid | 2.6mg/ml | 4.5 |
| 2 | Acetic acid | 3.5mg/ml | 3.2 |
| 3 | Perchloric acid | 3.0mg/ml | 1.0 |
Embodiment 2：A kind of hydrogel for treating dental ulcer of infant
A kind of hydrogel for treating dental ulcer of infant is included by gross weight meter：Mussel soft tissue extract dry powder 15mg,
Trypsase dry powder 20mg, honey 10mg, vitamin C 5mg, vitamin B1 5mg, vitamin B2 5mg, niacinamide 1.0mg,
Vitamin B12 1.0mg, water-soluble menthol 5mg and gel-type vehicle.
Embodiment 3：A kind of preparation method of the hydrogel for treating dental ulcer of infant
1) gel-type vehicle is dissolved in suitable quantity of water makes it fully swelling, adjusts pH value to 4.0-5.0；
2) by mussel soft tissue extract dry powder 15mg, trypsase dry powder 20mg, honey 10mg, vitamin C 5mg, dimension
Raw element B1 5mg, vitamin B2 5mg, niacinamide 1.0mg, vitamin B12 1.0mg, water-soluble menthol 5mg is dissolved in suitable quantity of water
In, stirring and dissolving；
3) by step 2) solution be added to step 1) in swelling good gel-type vehicle, stir；
4) by sweetener and the water stirring and dissolving of remaining recipe quantity, add step 3) matrix in, stir and evenly mix, by specification
Dispense the hydrogel of the dental ulcer of infant that obtains medical treatment.
60 infant thrush patients are collected, 30 is randomly selected as treatment group, in addition 30 as a control group.Treatment
The hydrogel of the treatment dental ulcer of infant that group is prepared using the embodiment of the present invention 3, is dried after mucous membrane with cotton swab, is applied in oral cavity
Affected part, 7 days is a course for the treatment of 3 times a day.Control group uses metronidazole oral sticking tabletses (Chinese medicines quasi-word H10930167), uses cotton
Label are dried after mucous membrane, adhere to oral cavity affected part, are within 7 days a course for the treatment of 3 times a day one at a time.
Curative effect is observed after one course for the treatment of.Criterion of therapeutical effect：Healing-oral mucosa considers in vain disappearance to be worth doing；In vain bits subtract improvement-oral mucosa
It is few；It is invalid：Oral mucosa is considered to be worth doing in vain unchanged.Therapeutic effect, is shown in Table 2.
The treatment curative effect of the hydrogel of the present invention treatment dental ulcer of infant of table 2
| Group | Case load | Cure | Take a turn for the better | It is invalid | Cure rate | It is efficient |
| Treatment group | 30 | 27 | 2 | 1 | 90% | 96.7% |
| Control group | 30 | 25 | 3 | 2 | 83.3% | 93.3% |
From the cure rate for the treatment of group in table 1 and it is efficient can be seen that, take the present invention treatment group's cure rate and it is total effectively
Rate is higher, it was demonstrated that the hydrogel of the present invention has significant curative effect to treating dental ulcer of infant.Additionally, controlling as can be seen from the table
Treatment group cure rate and total effective rate are above control group, and the hydrogel for further relating to present invention treatment dental ulcer of infant is more suitable for
In dental ulcer of infant patient.
Embodiment 4：A kind of spray for treating dental ulcer of infant
A kind of spray for treating dental ulcer of infant is included by gross weight meter：Mussel soft tissue extract dry powder 13.5mg,
Trypsase dry powder 18.5mg, honey 9mg, vitamin C 4.5mg, vitamin B1 3.5mg, vitamin B2 3.5mg, niacinamide
0.8mg, vitamin B12 0.8mg, water-soluble menthol 2.5mg, above-mentioned substance adds physiological saline to be prepared into spray after mixing.
20 dental ulcer of infant patients are collected, treatment group and control group is randomly divided into.Treatment group uses present invention enforcement
Hydrogel prepared by example 3, is dried after mucous membrane with cotton swab, is applied in oral cavity affected part, is within 7 days a course for the treatment of 3 times a day.Control group
The spray prepared using the embodiment of the present invention 4, is dried after mucous membrane with cotton swab, is sprayed at oral cavity affected part, is within 7 days one 3 times a day
The course for the treatment of.
Curative effect is observed after one course for the treatment of.Treatment group cures 8 people, and take a turn for the better 1 people, and efficient is 90%, and control group cures 6 people,
Take a turn for the better 1 people, and efficient is 70%.Efficacy result illustrates that compared with spray the hydrogel formulation of the present invention is to dental ulcer of infant
Therapeutic effect it is more preferable.
Certainly, the present invention can also have other various embodiments, ripe in the case of without departing substantially from spirit of the invention and its essence
Knowing those skilled in the art can make various corresponding changes and deformation, but these corresponding changes and deformation according to the present invention
The protection domain of the claims in the present invention should all be belonged to.
Claims (10)
1. a kind of hydrogel for treating dental ulcer of infant, comprising mussel soft tissue extract, trypsase, honey, vitamin,
Vitamin B1, vitamin B2, niacinamide, vitamin B12, water-soluble menthol and gel-type vehicle.
2. it is according to claim 1 treatment dental ulcer of infant hydrogel, it is characterised in that the treatment dental ulcer of infant
Hydrogel press gross weight meter：Mussel soft tissue extract 0.1-15 parts, trypsase 0.1-20 parts, honey 0.1-10 parts, dimension
Raw element C 0.1-5 parts, vitamin B1 0.1-5 parts, vitamin B2 0.1-5 parts, niacinamide 0.1-1 parts, vitamin B12 0.1-1
Part, water-soluble menthol 0.1-5 parts, gel-type vehicle, such as by gross weight meter：Mussel soft tissue extract is such as 0.1 part, 1
Part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5
Part, 9 parts, 9.5 parts, 10 parts, 10.5 parts, 11 parts, 11.5 parts, 12 parts, 12.5 parts, 13 parts, 13.5 parts, 14 parts, 14.5 parts, 15
Part, trypsase is such as 0.1 part, 0.2 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5
Part, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts, 10 parts, 10.5 parts, 11 parts, 11.5 parts, 12 parts, 12.5
Part, 13 parts, 13.5 parts, 14 parts, 14.5 parts, 15 parts, 15.5 parts, 16 parts, 16.5 parts, 17 parts, 17.5 parts, 18 parts, 18.5 parts, 19
Part, 19.5 parts, 20 parts, honey is such as 0.1 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts,
5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts, 10 parts, vitamin C is such as 0.1 part, 1 part, 1.5
Part, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, vitamin B1 is such as 0.1 part, 1 part, 1.5 parts, 2 parts, 2.5 parts,
3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, vitamin B2 is such as 0.1 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4
Part, 4.5 parts, 5 parts, niacinamide is such as 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9
Part, 1 part, vitamin B12 is such as 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1
Part, water-soluble menthol is such as 0.1 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, Yi Jining
Appropriate gel matrix.
3. according to arbitrary aforementioned claim treatment dental ulcer of infant hydrogel, it is characterised in that the water-setting
Glue also contains plant extracts.
4. it is according to claim 3 treatment dental ulcer of infant hydrogel, it is characterised in that the plant extracts be selected from Portugal
One or more in grape seed extract, Punica granatum L. extract, apple extract.
5. according to arbitrary aforementioned claim treatment dental ulcer of infant hydrogel, it is characterised in that the combination
Thing further includes auxiliary material, such as antioxidant, bacteriostatic agent, essence or host material；Or the composition is further included
Pharmaceutically acceptable carrier, such as solvent, salt, decentralized medium, coating material, surfactant, antioxidant, preservative
(such as antiseptic, antifungal agent), isotonic agent, absorption delaying agent, drug stabilizing agent, adhesive, excipient, disintegrant, lubrication
Agent, sweetener, flavouring, dyestuff and combination a kind of, various or whole in them.
6. according to arbitrary aforementioned claim treatment dental ulcer of infant hydrogel, it is characterised in that the mussel
Soft tissue extract, trypsase are dry powder or liquid.
7. according to arbitrary aforementioned claim treatment dental ulcer of infant hydrogel, it is characterised in that the combination
Thing final ph soluble in water is 3.8-5.8.
8. according to arbitrary aforementioned claim treatment dental ulcer of infant hydrogel, it is characterised in that the mussel
Soft tissue extract is the component raw material with mussel in addition to shell, is extracted through acidic aqueous solution, and supernatant acquisition is taken after centrifugation
, wherein protein content 0.2-15.0mg/ml, pH value 1.0-6.0；Or the dental ulcer of infant includes children's goose mouth
Sore, herpes simplex aphtha, exedens aphtha.
9. it is according to claim 8 treatment dental ulcer of infant hydrogel, wherein the acidic aqueous solution includes：Second
Acid-sodium acetate buffer, acetic acid, citric acid, perchloric acid, or the protein content example of wherein described mussel soft tissue extract
Such as 0.2mg/ml, 0.3mg/ml, 0.4mg/ml, 0.5mg/ml, 0.6mg/ml, 0.7mg/ml, 0.8mg/ml, 0.9mg/ml,
1.0mg/ml、1.5mg/ml、2.0mg/ml、2.5mg/ml、3.0mg/ml、3.5mg/ml、4.0mg/ml、4.5mg/ml、
5.0mg/ml、5.5mg/ml、6.0mg/ml、6.5mg/ml、7.0mg/ml、7.5mg/ml、8.0mg/ml、8.5mg/ml、
9.0mg/ml、9.5mg/ml、10.0mg/ml、10.5mg/ml、11.0mg/ml、11.5mg/ml、12.0mg/ml、12.5mg/
Ml, 13.0mg/ml, 13.5mg/ml, 14.0mg/ml, 14.5mg/ml and 15.0mg/ml；Or the mussel include Mytilus galloprovincialis,
One kind in Perna viridis, Trachyostracous mussel, two or three.
10. a kind of method prepared for treating the hydrogel of dental ulcer of infant, it is characterised in that including step：
1) gel-type vehicle is dissolved in suitable quantity of water makes it fully swelling, adjusts pH value to 4.0-5.0；
2) by mussel soft tissue extract, trypsase, honey, vitamin C, vitamin B1, vitamin B2, niacinamide, dimension life
Plain B12, water-soluble menthol are dissolved in suitable quantity of water, stirring and dissolving；
3) by step 2) solution be added to step 1) in swelling good gel-type vehicle, stir；With
4) by sweetener and the water stirring and dissolving of remaining recipe quantity, add step 3) matrix in, stir and evenly mix, dispense by specification
Obtain hydrogel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611254353.XA CN106620673A (en) | 2016-12-30 | 2016-12-30 | Hydrogel for treating infant dental ulcer and preparation method of hydrogel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611254353.XA CN106620673A (en) | 2016-12-30 | 2016-12-30 | Hydrogel for treating infant dental ulcer and preparation method of hydrogel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106620673A true CN106620673A (en) | 2017-05-10 |
Family
ID=58836334
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611254353.XA Withdrawn CN106620673A (en) | 2016-12-30 | 2016-12-30 | Hydrogel for treating infant dental ulcer and preparation method of hydrogel |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111184942A (en) * | 2020-03-18 | 2020-05-22 | 四川大学华西医院 | Soluble microneedle for treating chloasma |
| CN112546204A (en) * | 2019-09-10 | 2021-03-26 | 蔡娟 | Oral care solution for treating hand-foot-and-mouth disease and dental ulcer and preparation method thereof |
| RU2827882C1 (en) * | 2023-12-21 | 2024-10-03 | Сергей Владимирович Сирак | Wound healing gel for treating cheilitis and chronic lip fissures in patients with orthodontic pathology |
-
2016
- 2016-12-30 CN CN201611254353.XA patent/CN106620673A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112546204A (en) * | 2019-09-10 | 2021-03-26 | 蔡娟 | Oral care solution for treating hand-foot-and-mouth disease and dental ulcer and preparation method thereof |
| CN111184942A (en) * | 2020-03-18 | 2020-05-22 | 四川大学华西医院 | Soluble microneedle for treating chloasma |
| RU2827882C1 (en) * | 2023-12-21 | 2024-10-03 | Сергей Владимирович Сирак | Wound healing gel for treating cheilitis and chronic lip fissures in patients with orthodontic pathology |
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