CN103110609A - Film coating agent for treating dental ulcer and preparation method thereof - Google Patents

Abstract

The invention discloses a film coating agent for treating dental ulcer and a preparation method thereof. The film coating agent comprises the following raw materials: iodine chitosan, hydroxypropyl methyl cellulose, glacial acetic acid, polysorbate-20, glycerol, absolute ethyl alcohol, potassium iodate and purified water. The method for preparing the film coating agent comprises the following steps: (1) weighting the materials according to formula mass; (2) adding glacial acetic acid, polysorbate-20, glycerol and partial purified water to iodine chitosan, and then completely and uniformly stirring until complete dissolution; (3) adding hydroxypropyl methyl cellulose, and stirring overnight so as to completely dissolve, then adding absolute ethyl alcohol and uniformly stirring; (4) dissolving potassium iodate with a small amount of purified water, adding to the material in the former step, and then uniformly stirring; (5) adding the rest purified water to 100%, and then uniformly stirring; and (6) filling, and packaging to obtain the product. The film coating agent for treating the dental ulcer disclosed by the invention has the advantages of good stability, better sterilizing effect and convenience for use, so that the film coating agent can be applied clinically and can be used for treating dental ulcer.

Description

A kind of liniment for the treatment of oral ulcer and preparation method thereof

Technical field

The present invention relates to contain the dressing of polysaccharide derivates, particularly the chitosan iodine liniment for the treatment of oral ulcer.

Background technology

Oral ulcer is called again " aphtha ", is the superficial ulcer that occurs on oral mucosa, and large I is big or small from the grain of rice to Semen Glycines, circular or oval, and ulcer surface is recessed, congested on every side.Ulcer has the characteristics such as periodicity, recurrent and self limiting, is apt to occur in lip, cheek, lingual margin etc.It has been generally acknowledged that the cause of disease has extrinsic factor (virus and antibacterial) and endogenous inducement (variation of hormone, psychologic factors, malnutrition, systemic disease and immunologic function disorder) to interact and cause a disease.

Chitosan is a kind of macromolecular compound of biological property excellence, and after absorption iodine, the heat stability of iodine improves greatly, and is the same with other povidone iodine, and shell iodine can discharge elemental iodine, thereby has strong sterilization.This product is nontoxic, good stability, nonirritant.Bibliographical information has been arranged the sterilization effect of chitosan iodine (see " laboratory observation of chitosan iodine liquid bactericidal effect ", be stated from Hengyang Medical College's journal (medicine) 05 phase in 2000), its chitosan used is water-soluble chitosan.

In Chinese patent database, relate to the patent application of chitosan preparations treatment oral ulcer seldom, No. 200510023385.4 " a kind of medicine for the treatment of oral ulcer and preparation method thereof ", No. 200510025169.3 " chymotrypsin oral-cavity ulcer membrane " and No. 200810233762.0 " treating the medicine of oral ulcer " are only arranged.In such scheme, use a kind of raw material of chitosan as medicine, but do not used up to now the patent application of chitosan iodine preparation for treating oral ulcer.

Summary of the invention

The purpose of this invention is to provide a kind of liniment for the treatment of oral ulcer, it has advantages of that good stability, therapeutic effect are good, is mankind's health service.

Another purpose of the present invention is to provide the preparation method of the liniment for the treatment of oral ulcer, enables to realize clinical practical application.

The liniment of the treatment oral ulcer that the inventor provides, take chitosan iodine as main active, its raw materials quality formula is as follows:

Chitosan iodine 0.2%～5%

Hydroxypropyl emthylcellulose 1%～3%

Glacial acetic acid 0.1%～2.5%

Tween-20 2.0%～15%

Glycerol 0.2%～5%

Dehydrated alcohol 20%～45%

Potassium iodate 0.005%～0.5%

Purified water adds to 100%.

The preferred raw materials quality formula of the liniment for the treatment of oral ulcer is as follows:

Chitosan iodine 1%

Hydroxypropyl emthylcellulose 2%

Glacial acetic acid 0.5%

Tween-20 3%

Glycerol 1%

Dehydrated alcohol 30%

Potassium iodate 0.025%

Purified water adds to 100%.

Above-mentioned chitosan iodine take water-insoluble chitosan as raw material and the iodine complexation make.

Above-mentioned hydroxypropyl emthylcellulose, Tween-20, glycerol, dehydrated alcohol, potassium iodate, purified water all meet the requirement of the Pharmacopoeia of the People's Republic of China.

The liniment preparation method of the treatment oral ulcer that provides comprises the following steps:

1. according to the weighing of raw materials quality formula, standby;

2. add glacial acetic acid, Tween-20, glycerol, partial purification water to stir in chitosan iodine, make dissolving fully;

3. add hydroxypropyl emthylcellulose after, stirring is spent the night, and it is dissolved fully; Then add dehydrated alcohol, stir;

4. the purified water that takes a morsel dissolving potassium iodate, and join in the previous step material and mix, stir;

5. add to 100% with remaining purified water, stir;

6. fill, packing namely get product.

The using method of the liniment for the treatment of oral ulcer is external, is about to this liniment and is applied in the affected part, 2～3 times on the 1st.

In the liniment for the treatment of oral ulcer provided by the invention, chitosan iodine plays disinfection, promotes healing, glacial acetic acid is used for regulating pH value, and play collaborative solubilizing effect, Tween-20 plays solubilization, and glycerol plays blending and moisture-keeping function, and potassium iodate plays stabilizer function, hydroxypropyl emthylcellulose plays a part to increase viscosity, and purified water is diluent.Therefore, the present invention's liniment for the treatment of oral ulcer has the effects such as high-efficiency broad spectrum sterilization, antiinflammatory, pain relieving, the healing of promotion ulcer surface; This liniment is nontoxic, and to the oral mucosa nonirritant, good stability, advantage easy to use can be used for pain relieving and the treatment of oral ulcer.

The effect of clinical practice is: oral ulcer patient uses liniment of the present invention, and effective percentage reaches 100%, and cure rate reaches more than 90%.Typical case is: 1. certain man, 20 years old, people from Guiyang City, Guizhou Province, because of winter edible chaffy dish dish repeatedly, suffer from oral ulcer, uses liniment treatment of the present invention 2 days, fully recover.2. certain female, 43 years old, people from Chongqing City because liking the roasted seeds and nuts such as edible sunflower, Semen arachidis hypogaeae, pine nut, caused maxillary ulcer, was applied in the affected part, i.e. recovery from illness on the 3rd with the saline rear use liniment of the present invention of gargling.3. certain old people, 70 years old, the man, people from Longli County, Guizhou Province, because of the overlong time of warming oneself by a fire winter, dry mouth and parching tongue causes oral ulcer.Adopt liniment treatment of the present invention, recovery from illness on the 4th.

The specific embodiment

Describe the specific embodiment of the inventive method in detail by the following example:

EXAMPLE l

Prepare burden according to following formula: chitosan iodine 0.2g, hydroxypropyl emthylcellulose 1g, glacial acetic acid 0.1g, Tween-20 2g, glycerol 0.2g, dehydrated alcohol 20g, potassium iodate 0.005g, purified water adds to 100g.Add glacial acetic acid, Tween-20, glycerol, partial purification water to stir in chitosan iodine, make dissolving fully; Add afterwards hydroxypropyl emthylcellulose, stirring is spent the night, and it is dissolved fully; Then add dehydrated alcohol, stir; After this purified water that takes a morsel dissolving potassium iodate, and join in the previous step material and mix, stir; Purified water with remainder adds to 100g, stirs; Fill, packing namely get the liniment for the treatment of oral ulcer.

Embodiment 2

Prepare burden according to following formula: chitosan iodine 1g, hydroxypropyl emthylcellulose 2g, glacial acetic acid 0.5g, Tween-20 3g, glycerol 1g, dehydrated alcohol 30g, potassium iodate 0.025g adds to 100g with purified water.Method for making is with embodiment 1, the liniment of the oral ulcer that obtains medical treatment.

Embodiment 3

Prepare burden according to following formula: chitosan iodine 5g, hydroxypropyl emthylcellulose 3g, glacial acetic acid 2.5g, Tween-20 15g, glycerol 5g, dehydrated alcohol 45g, potassium iodate 0.5g adds to 100g with purified water.Method for making is with embodiment 1, the liniment of the oral ulcer that obtains medical treatment.

Claims (4)

1. a liniment for the treatment of oral ulcer, is characterized in that this liniment take chitosan iodine as main active, and its raw materials quality formula is as follows:

Chitosan iodine 0.2%～5%

Hydroxypropyl emthylcellulose 1%～3%

Glacial acetic acid 0.1%～2.5%

Tween-20 2.0%～15%

Glycerol 0.2%～5%

Dehydrated alcohol 20%～45%

Potassium iodate 0.005%～0.5%

Purified water adds to 100%.

2. liniment as claimed in claim 1, is characterized in that this liniment take chitosan iodine as main active, and its raw materials quality formula is as follows:

Chitosan iodine 1%

Hydroxypropyl emthylcellulose 2%

Glacial acetic acid 0.5%

Tween-20 3%

Glycerol 1%

Dehydrated alcohol 30%

Potassium iodate 0.025%

Purified water adds to 100%.

3. liniment as described in one of claim 1 or 2 is characterized in that described chitosan iodine take water-insoluble chitosan as raw material and the iodine complexation makes.

4. the method for preparing one of claim 1 or 2 described liniment, its feature comprises the following steps:

1. according to the weighing of raw materials quality formula, standby;

2. add glacial acetic acid, Tween-20, glycerol, partial purification water to stir in chitosan iodine, make dissolving fully;

3. add hydroxypropyl emthylcellulose after, stirring is spent the night, and it is dissolved fully; Then add dehydrated alcohol, stir;

4. the purified water that takes a morsel dissolving potassium iodate, and join in the previous step material and mix, stir;

5. add to 100% with remaining purified water, stir;

6. fill, packing namely get product.