CN105311050B - Seamless type Povidone Iodine Disinfection Solution - Google Patents
Seamless type Povidone Iodine Disinfection Solution Download PDFInfo
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- CN105311050B CN105311050B CN201510834421.9A CN201510834421A CN105311050B CN 105311050 B CN105311050 B CN 105311050B CN 201510834421 A CN201510834421 A CN 201510834421A CN 105311050 B CN105311050 B CN 105311050B
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Abstract
Seamless type Povidone Iodine Disinfection Solution disclosed by the invention, is prepared by following weight percent raw material：Polyvinylpyrrolidone 4.0% 4.5%, iodine 0.45% 0.55%, chelating agent 0.2% 0.8%, stabilizer 0.2% 0.8%, potassium hydroxide 0.1% 0.2%, disodium hydrogen phosphate 0.4% 0.8%, citric acid 0.2% 0.8%, potassium iodide 0.1% 0.5%, Potassiumiodate 0.2% 0.5%, water surplus.The present invention will be aided with certain chelating and technique for packing after iodine and polyvinylpyrrolidone complexing, it is made in 24 hours, to be washed away with clear water, naked-eye observation is almost without yellow trace on floor.Relative to common povidone iodine (Iodophor), in terms of to floor xanthochromia, there is larger advantage；To reduce the visual impact of operating room operating personnel and extend the service life of operating room floor.
Description
Technical field
The present invention relates to a kind of disinfectant tamed iodine, more particularly to a kind of seamless type Povidone Iodine Disinfection Solution.
Background technology
With the development of economy, the promotion of medical level, pursuit is higher and higher safely to operating room for people's door, and povidone iodine disappears
Venom is sterile products indispensable in a operating room.
Xanthochromia that is, during Iodophor use, contacts after a certain period of time with object, the phenomenon that being difficult to remove with clear water.Mesh
Before, public domain to be Iodophor can cause xanthochromia to skin, ground during use.In situations in the surgery room, povidone iodine (iodine
Volt) during use, inevitably trickled down on floor, since surgical procedure generally requires 6 hours or more, this
When cleaning worker even if cleaning is purged to ground.Due to the xanthochromia characteristic of Iodophor, it is difficult to remove to reuse clear water at this time, auxiliary
To remove idodine, although xanthochromia can be solved, cost can increased, and operation is also cumbersome, and time lengthening of keeping a public place clean reduces
The utilization rate of operating room.In addition undergo this period after Iodophor be dropped on floor it is caused irreversible yellow strain and
Damage, causes strong influence to the vision of doctor, seriously affects the safety of operation, and the floor service life also subtracts significantly
It is few.
Invention content
Technical problem to be solved by the present invention lies in asked for the above-mentioned technology present in existing Povidone Iodine Disinfection Solution
It inscribes and a kind of seamless type Povidone Iodine Disinfection Solution not generating xanthochromia is provided.The seamless type Povidone Iodine Disinfection Solution can not only be kept
The stability of Iodophor and the sterilizing rate under identical application method, trickle down on floor in 24 hours that wipe no xanthochromia with clear water existing
As.
The technical problems to be solved by the invention can be achieved through the following technical solutions：
Seamless type Povidone Iodine Disinfection Solution is prepared by following weight percent raw material：
In a preferred embodiment of the invention, the stabilizer is nonylphenol polyoxyethylene ether, alkyl phenol polyoxy second
The mixing of one or more of alkene ether, glycerine, polyethylene glycol, polyvinyl alcohol.
In a preferred embodiment of the invention, the chelating agent be EDTA-2Na, EDTA-4Na, PVP-K30,
The mixing of one or more of PVP-K90, hexadecyldimethyl benzyl ammonium benzylamine.
The present invention is used for maintaining product stability using potassium iodide with Potassiumiodate, using disodium hydrogen phosphate, citric acid, hydrogen-oxygen
Change potassium to be used for adjusting and stablizing pH value, has sustained release solubilization function using chelating agent and stabilizer.
The present invention will be aided with certain chelating and technique for packing after iodine and polyvinylpyrrolidone complexing, make it 24 on floor
It in a hour, is washed away with clear water, naked-eye observation is almost without yellow trace.Relative to common povidone iodine (Iodophor), to floor
In terms of xanthochromia, there is larger advantage；To reduce the visual impact of operating room operating personnel and extend making for operating room floor
Use the service life.
The present invention is that have the function of efficient, broad-spectrum sterilization by the thimerosal that povidone iodine is main sterilization component.
Major antibacterial ingredient in the present invention is povidone iodine, and povidone iodine has slow releasing function, safe to the human body stingless
Swash, disinfection can be rinsed to mucous membrane after diluting 10 to 20 times.
The test result of the sterilizing rate of the present invention is shown in Table 1
Table 1
Specific implementation mode
The present invention is described in detail below in conjunction with specific implementation mode, the following examples are only the description of the invention,
The limitation to the claims in the present invention protection domain is not constituted.
Embodiment 1
Seamless type Povidone Iodine Disinfection Solution is prepared by following weight percent raw material：Polyvinylpyrrolidone
4.5%, iodine 0.5%, EDTA-2Na 0.1%, nonylphenol polyoxyethylene ether 0.3%, potassium hydroxide 0.1%, disodium hydrogen phosphate
0.5%, citric acid 0.3%, potassium iodide 0.1%, Potassiumiodate 0.2%, remaining is water.
The bactericidal effect of the seamless type Povidone Iodine Disinfection Solution of the embodiment is shown in Table 2
Table 2
Embodiment 2
Seamless type Povidone Iodine Disinfection Solution is prepared by following weight percent raw material：Polyvinylpyrrolidone
4.5%, iodine 0.47%, EDTA-4Na 0.3%, alkyl phenol polyoxyethylene ether 0.5%, potassium hydroxide 0.2%, disodium hydrogen phosphate
0.7%, citric acid 0.5%, potassium iodide 0.2%, Potassiumiodate 0.3%, remaining is water.
The seamless type Povidone Iodine Disinfection Solution bactericidal effect of the embodiment is shown in Table 3
Table 3
Embodiment 3
Seamless type Povidone Iodine Disinfection Solution is prepared by following weight percent raw material：Polyvinylpyrrolidone
5.0%, iodine 0.5%, PVP-K300.6%, glycerine 0.1%, potassium hydroxide 0.2%, disodium hydrogen phosphate 0.6%, citric acid
0.45%, potassium iodide 0.3%, Potassiumiodate 0.4%, remaining is water.
The seamless type Povidone Iodine Disinfection Solution bactericidal effect of the embodiment is shown in Table 4
Table 4
Above-described embodiment is shown in Table 5 with existing povidone iodine, erasable iodine, common Iodophor test result
Table 5
Claims (1)
1. seamless type Povidone Iodine Disinfection Solution, which is characterized in that be prepared by following weight percent raw material：
The stabilizer is in nonylphenol polyoxyethylene ether, alkyl phenol polyoxyethylene ether, glycerine, polyethylene glycol, polyvinyl alcohol
A kind of or arbitrary two or more mixing；
The chelating agent is one kind in EDTA-2Na, EDTA-4Na, PVP-K30, PVP-K90, hexadecyldimethyl benzyl ammonium benzylamine
Or arbitrary two or more mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510834421.9A CN105311050B (en) | 2015-11-25 | 2015-11-25 | Seamless type Povidone Iodine Disinfection Solution |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510834421.9A CN105311050B (en) | 2015-11-25 | 2015-11-25 | Seamless type Povidone Iodine Disinfection Solution |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105311050A CN105311050A (en) | 2016-02-10 |
| CN105311050B true CN105311050B (en) | 2018-07-13 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510834421.9A Active CN105311050B (en) | 2015-11-25 | 2015-11-25 | Seamless type Povidone Iodine Disinfection Solution |
Country Status (1)
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106386853A (en) * | 2016-08-30 | 2017-02-15 | 四川创美克科技有限公司 | Multi-effect active iodine disinfectant as well as preparation method and application thereof |
| CN106821974B (en) * | 2017-03-29 | 2021-04-02 | 佛山市南海东方澳龙制药有限公司 | Preparation method of povidone-iodine solution and povidone-iodine solution prepared by same |
| CN107468706A (en) * | 2017-09-30 | 2017-12-15 | 蚌埠科卫消毒药剂有限公司 | A kind of disinfectant tamed iodine and preparation method thereof |
| CN107496448A (en) * | 2017-09-30 | 2017-12-22 | 蚌埠科卫消毒药剂有限公司 | A kind of Povidone Iodine Disinfection Solution and preparation method thereof |
| CN107595881A (en) * | 2017-09-30 | 2018-01-19 | 蚌埠科卫消毒药剂有限公司 | A kind of skin mucosa disinfectant and preparation method thereof |
| CN110037940A (en) * | 2019-05-22 | 2019-07-23 | 浙江欧洁科技股份有限公司 | A kind of sterilizing oral disinfection mouthwash and preparation method thereof and application method |
| CN112806387B (en) * | 2020-12-31 | 2022-02-25 | 佛山市正典生物技术有限公司 | Preparation method of iodine-containing disinfectant with stable component content |
| CN114149870B (en) * | 2021-12-16 | 2024-04-16 | 广东科伦药业有限公司 | Complex iodine floor disinfection cleaning agent and preparation process thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102488705A (en) * | 2011-12-08 | 2012-06-13 | 施耐克江苏生物制药有限公司 | Skin mucous membrane disinfectant for killing virus |
-
2015
- 2015-11-25 CN CN201510834421.9A patent/CN105311050B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102488705A (en) * | 2011-12-08 | 2012-06-13 | 施耐克江苏生物制药有限公司 | Skin mucous membrane disinfectant for killing virus |
Non-Patent Citations (1)
| Title |
|---|
| 聚乙烯吡咯烷酮—碘消毒剂的制备杀菌与应用;余五祥;《益阳师专学报》;20011130;第18卷(第6期);38-40 * |
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| CN105311050A (en) | 2016-02-10 |
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Effective date of registration: 20190418 Address after: Room B0830, 9 storeys, No. 2816 Yixian Road, Baoshan District, Shanghai, 2004 Patentee after: Jinli (Shanghai) Medical Technology Co., Ltd. Address before: 201300 No. 586 West Road, Nanhui Industrial Park, Pudong New Area, Shanghai Patentee before: Shanghai Yinjing Medical Supplies Co., Ltd. |
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