CN102488705A - Skin mucous membrane disinfectant for killing virus - Google Patents
Skin mucous membrane disinfectant for killing virus Download PDFInfo
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- CN102488705A CN102488705A CN201110404909XA CN201110404909A CN102488705A CN 102488705 A CN102488705 A CN 102488705A CN 201110404909X A CN201110404909X A CN 201110404909XA CN 201110404909 A CN201110404909 A CN 201110404909A CN 102488705 A CN102488705 A CN 102488705A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
The invention belongs to the field of medicinal disinfection, and particularly relates to a skin mucous membrane disinfectant for killing virus. The disinfectant provided by the invention comprises the following components: composite quaternary ammonium salt, ortho-phthalaldehyde, povidone iodine or other colorless iodine, a synergist, a surfactant, chlorine dioxide, ethanol, a chelating agent, a stabilizer, essence and a PH adjusting agent.
Description
Technical field:
The invention belongs to medicinal sterilization field, be specifically related to a kind of skin and mucous membrane disinfection agent that is used for kill virus.
Background technology:
As far back as 1915, Jacobs just report synthesized quaternary ammonium disinfectant, and has done germ-resistant research, points out that such sterilization has certain sterilizing ability, had opened the historical chapter of quaternary ammonium salt disinfectant, yet had never been paid attention to by people.Nineteen thirty-five, German Domagk has studied the relation of this type disinfectant bactericidal property and chemical constitution and system bacterium, causes the great interest of people.The same year, Wetzel promptly was used for the clinical disinfection practice.People to the research of this type disinfecting drug comes one after another subsequently; Be widely used in skin and mucous membrane disinfection, surgical hand sterilization and the medical apparatus sterilizing of hospital gradually; Also be used for the various public places apparatus next and the sterilization of equipment with producing each row; And the mildew-resistant of industrial goods and agriculture crops, the disinfecting aquaculture of animal house, algae are killed, plastic antimicrobial agent prepares, compound disinfectant preparation etc.
Quaternary ammonium salt disinfectant also is a kind of cationic surface active agent, and its molecular structure pattern is following:
In the structure, alkyl R
1, R
2, R
3And R
4Can be identical or different, substituted or non-substituted, saturated or unsaturated, branch can be arranged or do not have branch, can be circulus or linear chain structure, can comprise ether, ester, amide, also can be aromatic series or aromatic series substituent.Nitrogen-atoms links to each other with alkyl and forms positively charged cation group, is germ-resistant live part.X then is a negative ion, like halogen, and the negative ion of sulfate radical or other types.
The quaternary ammonium salt sterilization is gone into operation so far from eighties of last century the fifties, and kind reaches hundreds of, has only few species to have good bactericidal action.Comprise strand and double-chain quaternary ammonium salt class disinfectant.
The domestic market is used for Mucocutaneous disinfectant many to be main with antibacterial, seldom to have pair virus that deactivation is arranged at present.The hand-foot-mouth disease that took place in 2008 simultaneously, the H1N1 epidemic situation that took place in 2009 have all been explained; Develop a kind of can suppress or the skin and mucous membrane disinfection agent of inactivation of viruses is significant; Especially for doubtful rabies animal human body is caused disinfecting of wound surface; Can improve rabic initiation potential greatly, carry out the preceding Prevention Processing of immunoprophylaxis, have significant meaning more preventing and treating the rabies morbidity.
The present invention is number to be 201010237569.1 in one Chinese patent application; Denomination of invention is: the further improvement of doing on a kind of patent basis of the skin and mucous membrane disinfection agent that is used for kill virus, added new antiviral drugs, and make that the Disinfection Effect of disinfectant of the present invention is better; Subject range is wider; Characteristics such as it is faster to take effect, and safety is higher, and action time is longer.
Summary of the invention:
The purpose of this invention is to provide a kind of skin and mucous membrane disinfection agent that is used for kill virus.
Disinfectant of the present invention has killing effect rapidly and efficiently to antibacterial and virus, also has safe and effectively, and characteristics such as side effect is little are applicable to that animal grabs the wound surface sterilization of biting, and hands, skin, mucosa, the sterilization of wound, sterilization hands, body surface.
Disinfectant of the present invention comprises following composition:
Compound quaternary ammonium salt, OPA, povidone iodine or other colourless iodine, synergist, surfactant, chlorine dioxide, chelating agen, stabilizing agent, essence, PH regulator.
Wherein, said compound quaternary ammonium salt can be long-chain, short chain quaternary ammonium salt, perhaps is two long-chains, single long chain quaternary, can also be two long-chains or single pair of long-chain or several kinds of compound substances that different quaternary ammonium salts is formed.The working concentration of compound quaternary ammonium salt is 0.05～0.20%.Single two long chain quaternary concentration of component were than adjustable scope 3 or 4: 1.
Wherein, said povidone iodine or other colourless iodine, working concentration is 0.01～5.00%.
Wherein, said synergist is: disinfectant such as antiviral drugs such as idoxuridine, trifluorothymidine, ftibamzone, acyclovir, penciclovir, ribavirin and phenols, oxidation class, chlorhexidine acetate.Its working concentration is 0.01～2.0%.
Wherein, said surfactant is selected from: polyvinylpyrrolidone, non-ionic surface active agent or other cationic surface active substances, working concentration are controlled at polyvinylpyrrolidone 0.10～1.00%, surfactant 1.00～10.0%.
Wherein, said chlorine dioxide is a chloride type of material, and working concentration is 0.01～2.50%.
Wherein, said chelating agen is selected EDTA-2Na for use, or other chelating agen commonly used, and working concentration is 1～10mg/L.
Wherein, said stabilizing agent is selected from: cellulose derivatives such as cellulose, hydroxy methocel, or gelatin, arabic gum, agaropectin etc.Working concentration is according to dissimilar selections.
Wherein, said essence can be edible essence, also can be alcohols, esters that medicine, cosmetics use, or natural plants, mineral extract.
Wherein, said PH regulator, both inorganic base material NaOH, KOH, ammonium hydroxide; Also organic alkaloids sodium citrate, sodium succinate, sodium lactate; Also ethanolamine, diethanolamine, triethanolamine; Also inorganic or organic acid substance phosphoric acid, sulphuric acid, hydrochloric acid, malic acid, tartaric acid, glycolic, salicylic acid, acetic acid etc.These regulators can use separately, and two or more unites use.
Preferably, disinfectant of the present invention, be processed into by following composition:
Compound quaternary ammonium salt, 0.05～0.20%
OPA, 0.01～2.00%
Povidone iodine or other colourless iodine, 0.01～5.00%
Synergist, 0.01～2.00%
Surfactant, 1.00～10.00%
Chlorine dioxide, 0.01～2.50%
Chelating agen, 1.01～10.00mg/L
Stabilizing agent, 0.50～100.00mg/L
Essence, 0.01～10.0%
The PH regulator.Because of practical application (＜10%)
Wherein, preferred, compound quaternary ammonium salt is: two decyl alkyl dimethyl ammonium chlorides, N-zephiran.
Wherein, preferred, synergist is: in antiviral drugs such as idoxuridine, trifluorothymidine, ftibamzone, acyclovir, penciclovir, ribavirin and phenols, oxidation class, the chlorhexidine acetate one or more.
Wherein, preferred, surfactant is: non-ionic surface active agent.
Wherein, preferred, chelating agen is: EDTA-2Na.
Wherein, preferred, stabilizing agent is: hydroxy methocel.
Wherein, preferred, essence is: edible essence.
Wherein, preferred, the PH regulator is: alcamine compound.
Further, preferred disinfectant of the present invention, be processed into by following composition:
Compound quaternary ammonium salt, 0.20%
OPA, 0.20%
Povidone iodine or other colourless iodine, 0.20%
Synergist, 0.20%
Surfactant, 0.20%
Chlorine dioxide, 0.20%
Chelating agen, 10.00mg/L
Stabilizing agent, 10.00mg/L
Essence, 0.20%
The PH regulator uses (＜10.00%) because of practical situation
Other are preferred, and disinfectant of the present invention in an embodiment.
Another object of the present invention has been to provide the method for preparing of said disinfectant.
Specifically may further comprise the steps:
(1) compound quaternary ammonium salt, OPA, surfactant, synergist, chlorine dioxide, ethanol, chelating agen, stabilizing agent, essence are pressed the abundant mixed dissolution of configuration proportion.Add deionized water then to preparing total amount.
(2) regulate pH value: regulate disinfectant pH value to 4.0～about 12.0 with an amount of acid or alkaline matter.
(3) packing, storage: the bottle of packing is washed, dries, under the environment of cleaning, will go up the disinfectant that obtains of step and carry out packing, dress box and put into shady and cool dry place and preserve after the packing according to design specification.
Preferably, method for preparing of the present invention may further comprise the steps:
(1) compound quaternary ammonium salt, OPA, surfactant, synergist, chlorine dioxide, chelating agen, stabilizing agent, essence are pressed the abundant mixed dissolution of configuration proportion.Add deionized water then to preparing total amount.
(2) regulate pH value: regulate disinfectant pH value to 4.0～about 12.0 with an amount of acid or alkaline matter.
The present invention also provides the method for using of disinfectant:
(1) health hands, skin degerming, body surface: stock solution (sheet, sterile package are wiped in pasteurization towelette, sterilization) spraying or wiping, be 1 minute action time.
(2) wound surface, mucosa sterilization: stock solution (sheet, sterile package are wiped in pasteurization towelette, sterilization) spraying or wiping, be 1 minute action time, as when having viral infection, be 3 minutes action time.
Disinfectant of the present invention also should be noted that in use:
(1) disinfectant for external use must not be oral.Place the child to be difficult for touching the place.
(2) avoid using with anion surfactant and soap.
(3) any composition of these article there is the careful usefulness of allergy sufferers.
(4) lucifuge, sealing, protection against the tide, place cool place, dry place to preserve.
Disinfectant of the present invention is mainly used in skin, mucosa, wound kill virus.
Disinfectant of the present invention can effectively suppress, kill virus (comprising: poliovirus, rabies virus, hand-foot-mouth disease virus, herpesvirus, influenza virus and HIV etc.); Can also be used for kill bacteria (comprising: pathogenic entero becteria, pyococcus, pathogenic yeast, hospital infection common pathogen).
The present invention has introduced OPA compared with prior art, has also added new antiviral drugs simultaneously.Make the present invention in terms of existing technologies, Disinfection Effect is better, has produced synergy between the active component, and it is faster to take effect; Antiviral and antibacterial wider, side effect still less, safety is higher; Zest still less, can not mutagenesis property destruction, stability is better, the shelf-life is longer; Many characteristics such as cost is lower, and preparation technology is simple are fit to large-scale production.
The specific embodiment
Through following be specific embodiment, can more detailed explanation the present invention, but not as restriction.
Embodiment 1, disinfectant of the present invention
Disinfectant of the present invention, be processed into by following composition:
Compound quaternary ammonium salt, 0.10%
OPA, 0.01%
Povidone iodine or other colourless iodine, 0.01%
Synergist, 0.01%
Surfactant, 1.00%
Chlorine dioxide, 0.01%
Chelating agen, 1.00mg/L
Stabilizing agent, 0.50mg/L
Essence, 0.01%
The PH regulator uses (＜10.00%) because of practical situation
Wherein, compound quaternary ammonium salt is: two decyl alkyl dimethyl ammonium chlorides, N-zephiran.
Wherein, synergist is: antiviral drugs and disinfectant such as phenols, oxidation class or chlorhexidine acetate such as idoxuridine, trifluorothymidine, ftibamzone, acyclovir, penciclovir, ribavirin.
Wherein, surfactant is: non-ionic surface active agent.
Wherein, chelating agen is: EDTA-2Na.
Wherein, stabilizing agent is: hydroxy methocel.
Wherein, essence is: edible essence.
Wherein, the PH regulator is: alcamine compound.
Embodiment 2, disinfectant
Disinfectant of the present invention, be processed into by following composition:
Compound quaternary ammonium salt, 0.15%
OPA, 0.05%
Povidone iodine or other colourless iodine, 2.00%
Synergist, 0.05%
Surfactant, 5.00%
Chlorine dioxide, 0.2%
Chelating agen, 5.00mg/L
Stabilizing agent, 49.75mg/L
Essence, 5.00%
The PH regulator uses (＜10.00%) because of practical situation
Wherein, compound quaternary ammonium salt is: two decyl alkyl dimethyl ammonium chlorides, N-zephiran.
Wherein, synergist is: disinfectant such as antiviral drugs such as idoxuridine, trifluorothymidine, ftibamzone, acyclovir, penciclovir, ribavirin and phenols, oxidation class, chlorhexidine acetate.
Wherein, surfactant is: non-ionic surface active agent.
Wherein, chelating agen is: EDTA-2Na.
Wherein, stabilizing agent is: hydroxy methocel.
Wherein, essence is: edible essence.
Wherein, the PH regulator is: alcamine compound.
Embodiment 3, disinfectant
Disinfectant of the present invention, be processed into by following composition:
Compound quaternary ammonium salt, 0.18%
OPA, 0.08%
Povidone iodine or other colourless iodine, 3.00%
Synergist, 0.08%
Surfactant, 8.00%
Chlorine dioxide, 0.30%
Chelating agen, 8.00mg/L
Stabilizing agent, 75.00mg/L
Essence, 8.00%
The PH regulator uses (＜10.00%) because of practical situation
Wherein, compound quaternary ammonium salt is: two decyl alkyl dimethyl ammonium chlorides, N-zephiran.
Wherein, synergist is: disinfectant such as antiviral drugs such as idoxuridine, trifluorothymidine, ftibamzone, acyclovir, penciclovir, ribavirin and phenols, oxidation class, chlorhexidine acetate.
Wherein, surfactant is: non-ionic surface active agent.
Wherein, chelating agen is: EDTA-2Na.
Wherein, stabilizing agent is: hydroxy methocel.
Wherein, essence is: edible essence.
Wherein, the PH regulator is: alcamine compound.
Embodiment 4, disinfectant
Disinfectant of the present invention, be processed into by following composition:
Compound quaternary ammonium salt, 0.19%
OPA, 0.09%
Povidone iodine or other colourless iodine, 4.00%
Synergist, 0.09%
Surfactant, 9.00%
Chlorine dioxide, 0.40%
Chelating agen, 9.00mg/L
Stabilizing agent, 80.00mg/L
Essence, 9.00%
The PH regulator uses (＜10.00%) because of practical situation
Wherein, compound quaternary ammonium salt is: two decyl alkyl dimethyl ammonium chlorides, N-zephiran.
Wherein, synergist is: disinfectant such as antiviral drugs such as idoxuridine, trifluorothymidine, ftibamzone, acyclovir, penciclovir, ribavirin and phenols, oxidation class, chlorhexidine acetate.
Wherein, surfactant is: non-ionic surface active agent.
Wherein, chelating agen is: EDTA-2Na.
Wherein, stabilizing agent is: hydroxy methocel.
Wherein, essence is: edible essence.
Wherein, the PH regulator is: alcamine compound.
Embodiment 5, disinfectant
Disinfectant of the present invention, be processed into by following composition:
Compound quaternary ammonium salt, 0.13%
OPA, 0.03%
Povidone iodine or other colourless iodine, 2.00%
Synergist, 0.03%
Surfactant, 3.00%
Chlorine dioxide, 0.20%
Chelating agen, 3.00mg/L
Stabilizing agent, 40.00mg/L
Essence, 3.00%
The PH regulator uses (＜10.00%) because of practical situation
Wherein, compound quaternary ammonium salt is: two decyl alkyl dimethyl ammonium chlorides, N-zephiran.
Wherein, synergist is: disinfectant such as antiviral drugs such as idoxuridine, trifluorothymidine, ftibamzone, acyclovir, penciclovir, ribavirin and phenols, oxidation class, chlorhexidine acetate.
Wherein, surfactant is: non-ionic surface active agent.
Wherein, chelating agen is: EDTA-2Na.
Wherein, stabilizing agent is: hydroxy methocel.
Wherein, essence is: edible essence.
Wherein, the PH regulator is: alcamine compound.
Embodiment 6, disinfectant
Disinfectant of the present invention, be processed into by following composition:
Compound quaternary ammonium salt, 0.10%
OPA, 0.01%
Povidone iodine, 0.01%
Synergist, 0.01%
Surfactant, 1.00%
Chlorine dioxide, 0.01%
Chelating agen, 1.00mg/L
Stabilizing agent, 0.50mg/L
Essence, 0.01%
The PH regulator uses (＜10.00%) because of practical situation
Wherein, compound quaternary ammonium salt is: two decyl alkyl dimethyl ammonium chlorides,
Wherein, synergist is: idoxuridine.
Wherein, surfactant is: non-ionic surface active agent.
Wherein, chelating agen is: EDTA-2Na.
Wherein, stabilizing agent is: hydroxy methocel.
Wherein, essence is: edible essence.
Wherein, the PH regulator is: alcamine compound.
Embodiment 7, disinfectant
Disinfectant of the present invention, be processed into by following composition:
Compound quaternary ammonium salt, 0.15%
OPA, 0.05%
Povidone iodine, 2.00%
Synergist, 0.05%
Surfactant, 5.00%
Chlorine dioxide, 0.2%
Chelating agen, 5.00mg/L
Stabilizing agent, 49.75mg/L
Essence, 5.00%
The PH regulator uses (＜10.00%) because of practical situation
Wherein, compound quaternary ammonium salt is: the N-zephiran
Wherein, synergist is: trifluorothymidine.
Wherein, surfactant is: non-ionic surface active agent.
Wherein, chelating agen is: EDTA-2Na.
Wherein, stabilizing agent is: hydroxy methocel.
Wherein, essence is: edible essence.
Wherein, the PH regulator is: alcamine compound.
The development test of embodiment 8, disinfectant
Skin and mucous membrane disinfection agent of the present invention through Military Medical Science Institute of Chinese PLA detect stock solution can be in 60～180 seconds inactivation of viruses (comprising: poliovirus, rabies virus, hand-foot-mouth disease virus, herpesvirus, influenza virus and HIV etc.).
Test one, following be that the experimentation of disinfectant kill virus of the present invention is reported
Experimental technique:
One, equipment
1. Strain is used in test: poliovirus 1 type (PV-1 type, vaccine strain), the strain of HIV 1 type (HIV-1) U.S., rabies virus (CTN-1 strain), hand-foot-mouth disease virus (EV-71 strain), herpesvirus (VZV strain), influenza virus (H1N1 strain).
2. host cell: Vero cell, MT4 cell.
3. disinfectant effective ingredient and content: compound quaternary ammonium salt content is 1.80g/L～2.0g/L.
4. Tissue Culture Flask and 96 well culture plates.
5. constant water bath box, CO2 gas incubator, Biohazard Safety Equipment and adjustable pipette and aseptic equipment.
6. cell is kept culture medium, cell complete medium and hyclone.
7. deionized water and standard hard water.
The organic interfering material of 8.3% bovine serum albumin.
9. nertralizer solution: the PBS of 10g/L histidine, 3.0% tween 80 and 3g/ lecithin.
10. used disinfectant in testing:
The disinfectant of experimental group: embodiment 7
Matched group: one Chinese patent application number 201010237569 described disinfectant
Two, method
1. use titre for being 10
7～10
8TCID
50PV-1, CTN-1, EV-71, VZV, H1N1, HIV-1 viral suspension subsequent use with the organic chaff interference two-fold dilution of 3% bovine serum albumin respectively.
2. nertralizer qualification test: remove the residual disinfectancy agent with dilution method in the employing.Test uses skin and mucous membrane disinfection agent of the present invention to be stock solution.Action time 2min, experimental temperature is 20 ℃ ± 1 ℃.Test repetition 3 times.
3. various viruses are killed test: remove the residual disinfectancy agent with dilution method in the employing.Test uses skin and mucous membrane disinfection agent of the present invention to be stock solution.Be 1.5min, 3min and 4.5min action time, and test temperature is 20 ℃ ± 1 ℃.Test repetition 3 times.
Three, result
Virus is killed test
Purpose is to study the present invention's influence to viral killing effect after adding antiviral drugs and OPA composition.
Under 20 ℃ ± 1 ℃ condition of test temperature; Through 3 repeated trials; The skin mucous membrane disinfectants of experimental group is stock solution effect 3 minutes; All about 5, effect is far superior to the matched group disinfectant solution to the average deactivation logarithm value of, H1N1 virus viral to poliovirus, rabies virus, EV-71 virus, VZV and HIV-1 virus.It is better to viral killing effect after adding antiviral drugs and OPA composition to further specify the present invention.
The agent of table 1 skin and mucous membrane disinfection is to each viral deactivation logarithm value
The average deactivation logarithm value of effect 3min
Four, conclusion:
1. in adopting and dilution method; Show in the employing and the used nertralizer of the dilution method skin mucous membrane disinfectants of the present invention that can effectively neutralize, and nertralizer solution influences poliovirus 1 type, HIV 1 type, rabies virus, hand-foot-mouth disease virus, herpesvirus, influenza virus and cell growth nothing with neutralized reaction product solution.
2. under 20 ℃ ± 1 ℃ condition of test temperature; Skin mucous membrane disinfectants effect 3min of the present invention, to the deactivation logarithm value of poliovirus 1 type, HIV 1 type, rabies virus, hand-foot-mouth disease virus, herpesvirus, influenza virus all about 5.00.Prove that disinfectant solution of the present invention is effectively to the killing effect of virus, and on effect, be superior to existing disinfectant.
Embodiment 9, Application of disinfectants scope
Disinfectant of the present invention has effective killing action to poliovirus, rabies virus, hand-foot-mouth disease virus, HIV, influenza virus, herpesvirus, can be on the human body skin surface, mucomembranous surface, the spraying of damaged wound or wiping use.The instant use can effectively be blocked contingent virus is invaded human body through skin, mucosa, damaged wound process.
Disinfectant of the present invention is used in skin, mucosa, damaged wound, reaches not cause in the hands disinfecting process that toxicity, zest, mutagenicity destroy.
Disinfectant of the present invention has fine instantaneity and persistency; Needn't frequently reuse; Just can reach the effect of sterilizing, kill virus, repeated use can not cause skin, mucosal injury yet, can not cause situation such as damaged wound is further hemorrhage, pain sensation reinforcement yet.
Disinfectant of the present invention can be kept the stability of its active constituent content room temperature preservation 24 months.
Claims (10)
1. a skin and mucous membrane disinfection agent is characterized in that, comprises following composition:
Compound quaternary ammonium salt, OPA, povidone iodine or other colourless iodine, synergist, surfactant, chlorine dioxide, ethanol, chelating agen, stabilizing agent, essence, PH regulator.
2. disinfectant according to claim 1 is characterized in that, comprises following composition:
Compound quaternary ammonium salt, 0.05～0.20%
OPA, 0.01～2.00%
Povidone iodine or other colourless iodine, 0.01～5.00%
Synergist, 0.01～2.00%
Surfactant, 1.00～10.00%
Chlorine dioxide, 0.01～2.50%
Chelating agen, 1.01～10.00mg/L
Stabilizing agent, 0.50～100.00mg/L
Essence, 0.01～10.0%
The PH regulator is because of practical application (＜10%)
Said compound quaternary ammonium salt is long-chain, short chain quaternary ammonium salt, perhaps is two long-chains, single long chain quaternary, perhaps is two long-chains or single pair of long-chain or several kinds of compound substances that different quaternary ammonium salts is formed, and the concentration of compound quaternary ammonium salt is 0.05～0.20%,
Said povidone iodine or other colourless iodine, its concentration is 0.01～5.00%,
Said synergist is: disinfectant such as antiviral drugs such as idoxuridine, trifluorothymidine, ftibamzone, acyclovir, penciclovir, ribavirin and phenols, oxidation class, chlorhexidine acetate, and its concentration is 0.01～2.00%,
Said surfactant is selected from: polyvinylpyrrolidone, non-ionic surface active agent or other cationic surface active substances, and wherein, the concentration of polyvinylpyrrolidone is 0.10～1.00%, surfactant concentrations is 1.00～10.00%,
The concentration of said chlorine dioxide is 0.01～0.50%,
Said chelating agen is selected EDTA-2Na for use, or other chelating agen commonly used, and its concentration is 1～10mg/L,
Said stabilizing agent is selected from: cellulose derivatives such as cellulose, hydroxy methocel, or gelatin, arabic gum, agaropectin,
Said essence is selected edible essence for use, or the cosmetics alcohols, the esters that use, or natural plants, mineral extract,
Said PH regulator is selected inorganic base material NaOH, KOH, ammonium hydroxide for use; Perhaps organic alkaloids: sodium citrate, sodium succinate, sodium lactate; Perhaps be selected from: ethanolamine, diethanolamine, triethanolamine; Perhaps be selected from inorganic or organic acid substance: phosphoric acid, sulphuric acid, hydrochloric acid, malic acid, tartaric acid, glycolic, salicylic acid, acetic acid, in one or several mixing.
3. disinfectant according to claim 1 is characterized in that, is processed into by following composition:
Compound quaternary ammonium salt, 0.20%
OPA, 0.20%
Povidone iodine or other colourless iodine, 0.20%
Synergist, 0.20%
Surfactant, 0.20%
Chlorine dioxide, 0.20%
Chelating agen, 10.00mg/L
Stabilizing agent, 10.00mg/L
Essence, 0.20%
The PH regulator uses (＜10.00%) because of practical situation.
4. disinfectant according to claim 3 is characterized in that,
Wherein, compound quaternary ammonium salt is: two decyl alkyl dimethyl ammonium chlorides, N-zephiran,
Wherein, synergist is: disinfectant such as antiviral drugs such as idoxuridine, trifluorothymidine, ftibamzone, acyclovir, penciclovir, ribavirin and phenols, oxidation class, chlorhexidine acetate,
Wherein, surfactant is: non-ionic surface active agent,
Wherein, chelating agen is: EDTA-2Na,
Wherein, stabilizing agent is: hydroxy methocel,
Wherein, essence is: edible essence,
Wherein, the PH regulator is: alcamine compound.
5. disinfectant according to claim 3 is characterized in that, is processed into by following composition:
Wherein, compound quaternary ammonium salt is: two decyl alkyl dimethyl ammonium chlorides, N-zephiran,
Wherein, povidone iodine or other colourless iodine are: povidone iodine,
Wherein, surfactant is: polyvinylpyrrolidone,
Wherein, chelating agen is: EDTA-2Na,
Wherein, stabilizing agent is: hydroxy methocel,
Wherein, essence is: edible essence,
Wherein, the PH regulator is: NaOH.
6. disinfectant according to claim 1 is characterized in that, is processed into by following composition:
Compound quaternary ammonium salt, 0.15%
OPA, 0.05%
Povidone iodine, 2.00%
Synergist, 0.05%
Surfactant, 5.00%
Chlorine dioxide, 0.2%
Chelating agen, 5.00mg/L
Stabilizing agent, 49.75mg/L
Essence, 5.00%
The PH regulator uses (＜10.00%) because of practical situation
Wherein, compound quaternary ammonium salt is: the N-zephiran
Wherein, synergist is: trifluorothymidine
Wherein, surfactant is: non-ionic surface active agent
Wherein, chelating agen is: EDTA-2Na
Wherein, stabilizing agent is: hydroxy methocel
Wherein, essence is: edible essence
Wherein, the PH regulator is: alcamine compound.
7. the method for preparing of described any one disinfectant of claim 1-6 is characterized in that, may further comprise the steps:
(1) compound quaternary ammonium salt, OPA, surfactant, synergist, chlorine dioxide, ethanol, chelating agen, stabilizing agent, essence are pressed the abundant mixed dissolution of configuration proportion, add deionized water then to preparing total amount,
(2) regulate pH value: regulate disinfectant pH value to 4.0～12.0 with an amount of acid or alkaline matter,
(3) packing, storage: the bottle of packing is washed, dries, under the environment of cleaning, will go up the disinfectant that obtains of step and carry out packing, dress box and put into shady and cool dry place and preserve after the packing according to design specification.
8. described any one disinfectant of claim 1-6 (sheet, sterile package are wiped in pasteurization towelette, sterilization) is used to kill the virus and the antibacterial of skin, mucosa, wound, health hands and body surface.
9. application according to claim 8 is characterized in that, said virus comprises: viruses such as poliovirus, rabies virus, hand-foot-mouth disease virus, herpesvirus, first (second, third) HBV B, influenza virus and HIV.
10. application according to claim 8 is characterized in that, said antibacterial comprises: pathogenic entero becteria, pyococcus, pathogenic yeast, hospital infection common pathogen.
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