CN114680142A - Application of natural composition as disinfectant in blocking virus transmission - Google Patents
Application of natural composition as disinfectant in blocking virus transmission Download PDFInfo
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/34—Rosaceae [Rose family], e.g. strawberry, hawthorn, plum, cherry, peach, apricot or almond
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
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Abstract
The invention relates to an application of a natural composition as a disinfectant in blocking virus transmission, wherein viruses which can be blocked by the natural composition comprise: the natural composition is used for blocking the application of the composition for virus propagation in killing articles and the environment, and has very wide market application prospect and value.
Description
Technical Field
The invention belongs to the field of biological medicine, relates to application of a natural composition as a disinfectant in blocking virus transmission, and particularly relates to application of the natural composition in preventing and killing coronavirus on food.
Background
The traditional Chinese medicine considers that: the lung governs respiration and opens into the nose, warms up the pathogenic factors, first enters the lung to prevent epidemic diseases, and most importantly, the spread of epidemic qi is cut off to protect the nose, mouth and skin of a human body. The experts in traditional Chinese medicine indicate that: the prevention of Chinese herbs can be expressed in two sentences, one sentence called strengthening body qi and the second sentence called avoiding pathogenic qi. The traditional Chinese medicine has four flavors and five flavors, and the aromatic traditional Chinese medicine can play the roles of avoiding plague, avoiding dirty, refreshing, restoring consciousness, relieving stuffiness and inducing resuscitation, and can prevent infectious diseases such as influenza, for example, pepper and aniseed are common traditional Chinese medicines and also are aromatic famous materials for making dishes.
The research of modern medicine finds that the plant volatile oil is the material basis of aromatic traditional Chinese medicines, and in vitro tests find that the volatile oil has certain bacteriostatic and antiviral effects, is aromatic and avoids dirt, and changes the living environment where viruses attach. For example, shikimic acid, a component in Chinese medicinal anise, is a raw material for preparing oseltamivir and is used for developing anti-avian influenza medicaments.
Coronaviridae (Coronaviridae) viruses are a large group of viruses that are widely found in nature and infect vertebrates such as humans, mice, pigs, cats, dogs, wolves, chickens, cattle, birds. The human disease that can be caused by the disease is mainly respiratory infection (including severe acute respiratory syndrome, SARS). The virus is very temperature sensitive and grows well at 33 ℃ but is inhibited at 35 ℃. Due to this property, winter and early spring are the epidemic seasons of the viral disease. Coronavirus is one of the main pathogens of common cold of adults, the infection rate of children is high, the infection is mainly upper respiratory tract infection, the main symptoms are watery stool, fever and vomiting, serious patients even have watery stool, and the nervous system syndrome is caused in rare cases.
Therefore, the market urgently needs to develop a product which can effectively kill or prevent the coronavirus on the food, the product belongs to a disinfection or external preparation, can be used for manufacturing, storing, transporting, selling and using the food, can also be used for carrying out comprehensive disinfection and sterilization and personal daily protection measures of the surrounding environment of the high-risk area with important epidemic situation, and can play a role in preventing the spread and infection of the new coronavirus, so the invention has great significance.
The virus is sensitive to heat, and can be inactivated at 56 deg.C for 90min or 75 deg.C for 30 min; the effective time of ultraviolet irradiation is 30 min. Common disinfectants, such as 75% by volume ethanol, iodophors, mid-range quaternary ammonium salts, chlorine-containing species, peroxides and other chemical disinfectants, can be effectively killed within a specified time. In addition, hydrogen peroxide aerosol spraying, peracetic acid heating fumigation, pulse ultraviolet sterilization technology, visible light sterilization technology and the like are used as novel disinfectants and sterilization technologies, the inactivation effect on novel coronavirus is good, and the device is suitable for surface sterilization of objects. Chlorine disinfectants are commonly used in the market. The disinfectants such as bleaching powder, sodium hypochlorite, chlorine dioxide, sodium dichloroisocyanurate, sodium trichloroisocyanurate and the like can generate pungent chlorine in the disinfection process, so that the disinfectants are corrosive to a certain extent, have great harm to human bodies and damage the environment to a certain extent by residues of the disinfectants.
The natural composition comprises hawthorn kernel dry distillation oil, dry distillation liquid and other components, and comprises but is not limited to raw material products of Honghua medicinal preparations produced by Shandong step-size Shenzhou pharmaceutical Co Ltd, wherein the Honghua medicinal preparations are Fujie lotion, and the national standard number of the medicine is Z10980131. In vitro cell screening tests show that the traditional Chinese medicine lotion of the natural composition has a remarkable killing effect on the novel coronavirus.
The applicant expects that the natural composition of the present invention can be widely applied to environmental disinfection and personal disinfection, and the natural composition of the present invention is expected to be applied to disinfection of the food industry chain, thereby being beneficial to protection of food practitioners and consumers, but because the traditional Chinese medicine lotion and the food preparation of the natural composition are different, and the auxiliary materials, the preparation and the application environment are different, whether the natural composition of the present invention can be applied to disinfection of the food industry chain needs to be deeply researched, such research is not simply pushed forward, and the applicant has conducted deep research and development to meet the long-term need of epidemic situation prevention and control.
Disclosure of Invention
The invention provides an application of a natural composition as a disinfectant in blocking virus transmission, and the natural composition is used for preparing the disinfectant for blocking virus transmission, particularly for disinfecting cold chain transmission paths, articles and the surrounding environment. The invention has the advantages of wide virus killing range, controllable production quality, high efficiency and environmental protection, and is a product with controllable production cost and better market prospect.
The invention provides an application of a natural composition in blocking virus propagation, wherein the natural composition comprises the following components in parts by weight: 3-7 parts of hawthorn seed dry distillation oil.
As a preference of the present invention, the composition of the natural composition further comprises: 18-22 parts of hawthorn seed dry distillation liquid.
As a further preferred of the present invention, the natural composition is: 3-7 parts of hawthorn seed dry distillation oil and 18-22 parts of hawthorn seed dry distillation liquid.
The present invention provides for the use of a natural composition to block viral transmission, including but not limited to the cold chain.
The present invention provides the use of a natural composition to block viral transmission by any route including, but not limited to, food manufacture, storage, transportation, sale, use.
The invention provides an application of a natural composition in blocking virus transmission, and an application of the natural composition in preventing and killing coronavirus on food.
The invention provides an application of a natural composition in blocking virus transmission, wherein the natural composition comprises the following components in parts by weight: 5 parts of hawthorn seed dry distillation oil, 20 parts of hawthorn seed dry distillation liquid, 50 parts of deionized water and a proper amount of food auxiliary materials; the preparation can be made into external preparation, cleaning solution, gel, hand sanitizer and spray.
The invention provides an application of a natural composition in blocking virus transmission, and a preparation method of the natural composition comprises the following steps:
mixing the semen crataegi dry distillation oil and semen crataegi dry distillation liquid, adding food grade adjuvants, stirring at room temperature for 20-40 min to obtain mixed solution, standing, and filtering to obtain natural composition;
the natural composition can be in the form of solution, gel, spray, aerosol, disinfectant, liniment, or liquid smoke.
The invention provides an application of a natural composition in blocking virus transmission, and a preparation method of the natural composition comprises the following steps:
the method comprises the steps of putting hawthorn kernel dry distillation oil into a batching cylinder, adding 120-mesh screen food auxiliary materials, and stirring for 30 minutes at normal temperature;
adding the hawthorn kernel dry distillation liquid into the liquid medicine in the step, and stirring for 30 minutes at normal temperature to obtain a mixed liquid A;
adding purified water into the mixed solution obtained in the second step, and stirring at normal temperature for 30 minutes to obtain a mixed solution B;
fourthly, standing the mixed liquid B obtained in the step three for 4 hours, and filtering to obtain the liquid B.
The invention provides an application of a natural composition in blocking transmission of coronavirus, and an application of the natural composition in preparing a medicine for preventing and killing coronavirus.
Viruses that can be blocked by the natural composition of the invention include: single-stranded RNA viruses, double-stranded RNA viruses, single-stranded DNA viruses, and double-stranded DNA viruses;
the virus of the invention comprises: adenovirus, herpesvirus, poxvirus, reovirus, small DNA virus, togavirus, orthomyxovirus, paramyxovirus, cannonball virus, hepatitis a virus, hepatitis b virus, hepatitis c virus, hepatitis e virus, poliovirus, aids virus, encephalitis b virus, dengue fever virus, yellow fever virus, west nile virus, japanese encephalitis virus, tick-borne encephalitis virus, hemorrhagic fever virus, bovine viral diarrhea virus, zaka virus, measles virus, rabies virus, influenza virus, avian influenza virus, swine influenza virus, ebola virus, rotavirus, coronavirus, SARS virus, MERS virus;
the coronavirus of the present invention is preferably SARS-COV-2 novel coronavirus.
The natural medicine composition can block viruses, can also comprise bacteria (common in daily life: escherichia coli, salmonella, staphylococcus aureus and the like), mycoplasma, chlamydia and other germs, and expands the disinfection range.
The in vitro cell experiment of the present invention is represented by the novel coronavirus (SARS-COV-2), and the diseases prevented and killed by the present invention are not limited to the novel coronavirus, and can also refer to the coronavirus similar to the novel coronavirus.
The active component of the natural composition is a hawthorn seed extract, and all active component substances of the natural composition are hawthorn seed dry distillation liquid and hawthorn seed dry distillation oil. The extraction process method of the effective substance components comprises the following steps: taking hawthorn kernels, placing the hawthorn kernels in a dry distillation kettle, wherein the feeding amount is 55 percent of the volume ratio of equipment, adopting a dynamic dry distillation process taking nitrogen as a driving force, heating up at a rate of 40 ℃/h, controlling the reaction process of dry distillation liquid, keeping the pressure in the dry distillation kettle at 0.04-0.12MPa, heating at 160-190 ℃ for 1 h, collecting dry distillation products at the temperature of above 160 ℃, keeping the temperature at 250-280 ℃ for 3 h, and collecting fractions to obtain the hawthorn kernel dry distillation liquid and the dry distillation oil. The component research of the substances shows that the substances mainly contain various effective components such as organic acid, ursolic acid, furfuryl aldehyde, phenols and the like.
The natural composition can be prepared into a dosage form of solution, emulsion, cleaning liquid, gel, spray, aerosol, disinfectant, hand sanitizer, liniment, liquid smoke and the like by utilizing the hawthorn seed extract and adding the commonly used auxiliary materials.
Cleaning liquid agent: the hawthorn seed extract is mixed with a proper amount of auxiliary materials to prepare cleaning liquid. The selected solvents were: water, glycerol, ethanol, propylene glycol, fatty oil, etc. The solubilizer is as follows: sodium stearate, lauric acid, triethanolamine organic soap, alkali metal soap, sulfated castor oil, sodium lauryl sulfate, lecithin and soybean lecithin. Cosolvent: benzoic acid, potassium iodide, and the like. Latent solvent: glycerol, ethanol, propylene glycol, and the like. The preservatives selected were: sodium benzoate, sorbic acid, benzalkonium bromide, parabens, and the like.
Gelling agent: mixing semen crataegi extract with adjuvant, and making into gel. The selected aqueous gel matrix comprises: tragacanth, gelatin, polyethylene glycol, povidone, polyvinyl acetate, cellulose derivatives, propylene glycol, sodium alginate, carbomer, and the like. Oily gel bases, such as: liquid paraffin, polyoxyethylene, fatty oil, colloidal silica, aluminum soap or zinc soap, etc. Preservatives, such as: methyl paraben, benzalkonium bromide, and the like. Humectants, such as: polyethylene glycol, glycerol, propylene glycol, sorbitol, sodium pyrrolidone carboxylate, PDS-3 high-efficiency humectant, etc. Oils, such as: ethoxylated esters, almond oil, and the like. pH regulators, such as triethanolamine, sodium hydroxide, etc. Solubilizers, such as: PEG-40 hydrogenated castor oil or Tween 80.
Liquid soap: the hawthorn seed extract is mixed with a proper amount of pharmaceutical excipients to prepare a liquid soap or a liniment. The material is selected from dispersion medium, high concentration ethanol. Cationic bactericide: quaternary ammonium salts such as: benzalkonium chloride, benzylalkyl ammonium chloride, cetylpyridinium chloride, dialkyl dimethyl ammonium halides, monoalkyl benzylalkyl ammonium halides; biguanides such as chlorhexidine gluconate, chlorhexidine acetate, chlorhexidine hydrochloride, polyhexamethylene guanidine, etc. Thickening agent: including alkanolamides such as coconut diethanolamide, coconut monoethanolamide, coconut monoisopropanolamide, cocoamide, lauroyl-linoleoyl diethanolamide, lauroyl-myristoyl diethanolamide, isostearyl diethanolamide, linoleoyl diethanolamide, and the like. The surface active agent is: tea saponin, quillaja acid, cholesterol, phospholipid, Arabic gum, tragacanth gum, alginic acid, chitosan and the like. Nonionic surfactant: alkyl glycoside, coconut oil diethanolamide, lauramidopropyl amine oxide, sucrose ester, alkylphenol polyoxyethylene ether, etc. Zwitterionic surfactants: cocamidopropyl betaine or dodecyl dimethyl betaine. Anionic surfactant: sodium fatty alcohol-polyoxyethylene ether sulfate, secondary alkyl sodium sulfonate, fatty acid methyl ester sodium sulfonate, a-alkenyl sulfonate, sodium dodecyl sulfate, sodium lauroyl sarcosinate, potassium alkyl phosphate, sodium alkyl phosphate, ammonium alkyl sulfate and the like. pH regulator: and (4) citric acid. Humectant: glycerol, ethylene glycol, sorbitol, and the like. Essence: osmanthus essence, apple essence, lavender essence and the like.
Spraying agent: mixing semen crataegi extract with appropriate amount of medicinal adjuvants, and making into spray. The selected medicinal auxiliary material solubilizers are as follows: absolute ethyl alcohol, distilled water, and the like. Humectant: propylene glycol, glycerol, polyethylene glycol, and the like. Surfactant (B): such as polyethylene glycol, tween 80, sodium dodecyl sulfate, and the like. Preservative: methyl paraben, ethyl paraben, benzalkonium chloride, benzalkonium bromide, chlorhexidine acetate, and the like. pH regulator: one or more of disodium citrate, trisodium citrate, sodium citrate, citric acid monohydrate, potassium citrate, sodium carbonate, sodium bicarbonate, potassium bicarbonate, sodium hydroxide, potassium hydroxide, phosphate, dihydrogen phosphate, hydrogen phosphate, tartaric acid, tartrate, hydrogen tartrate, amino acid and salts thereof. Antioxidant: sulfurous acid, sulfites, bisulfites, pyrosulfites, thiosulfates, ascorbic acid, and the like. Aromatic agent: natural or synthetic essence and flavor including rose essence, clove oil, eucalyptus oil, etc.
The natural composition of the invention has the following beneficial effects: the in vitro efficacy test proves that the natural composition has stronger killing effect on the novel coronavirus (SARS-COV-2), the selected active components are various effective active components such as phenols (phenol, 2-methylphenol, guaiacol, 2-methoxy-4-methylphenol and the like), aldehydes (furfural), ketones, organic acids and the like contained in the hawthorn seed extract, and the natural composition has stronger in vitro sterilization, killing and virus replication inhibition effects.
The hawthorn seed extract of the natural composition can be prepared into the following components: solution, lotion, fat emulsion, cleaning solution, gel, spray, aerosol, disinfectant, hand sanitizer, liniment and liquid smoke.
The use of one of the natural compositions of the present invention as a prophylactic and/or a disinfectant against new coronaviruses provides the use of blocking the transmission of coronaviruses through routes including, but not limited to, the cold chain.
The use of one of the natural compositions of the present invention as a prophylactic and/or a disinfectant against new coronaviruses provides the use of blocking the transmission of coronaviruses through routes including, but not limited to, the manufacture, storage, transportation, sale, use of food products.
The natural composition also has the advantages of stable quality, lower production cost, obvious industrialization and very wide market application prospect and value.
The use method of the natural composition of the invention is characterized in that the preparation of the natural composition of the invention is applied to the surface of the food in modes of smearing, rubbing, smearing, soaking, washing, spraying, atomizing, gasifying and the like, and is used for cleaning the food.
The product of the invention is used in seafood, fresh seafood, aquatic products, slaughtering products, including meat products, bone products, viscera products, skin products, hoof products, ear products and the like. The use of the products of the invention relates to the entirety and to the processed products of these products. The food is in the form of block, powder, granule, paste and liquid.
The product of the invention is used in manual operation and mechanical operation, and has high automation degree.
The present invention is further illustrated by the following exemplary embodiments in order that the practice of the invention may be more fully understood. The natural composition of the invention has good treatment effect as proved by in vitro antiviral tests.
Examples of the experiments
1. Experimental report for in vitro screening of novel coronavirus (SARS-COV-2)
1.1, purpose of experiment
The anti-novel coronavirus (SARS-COV-2) effect of the Chinese medicinal preparation of the natural composition of the present invention was evaluated at the cellular level during the emergency of epidemic situation.
1.2, experimental materials:
1.2.1 test drugs: tests are carried out by adopting different drug concentrations of the traditional Chinese medicine preparation of the natural composition, and the name and the concentration of the drug are shown in table 1.
1.2.2 test cells: VeroE6 cells, maintained by the national stress laboratory Virus of respiratory diseases of the respiratory health institute, Guangzhou.
1.2.3 viral column sources tested: SARS-CoV-2, titer TCID50＝10-6100 μ L, stored at 80 ℃ in BSL-3 laboratory (respiratory disease national center laboratory high pathogenic microorganism research laboratory). The virus titer of 100TCID was used50。
1.3, experimental method:
1.3.1 sample preparation
The traditional Chinese medicine preparation (the red-core Fujie lotion) of the natural composition is respectively diluted by 800 times, 1000 times, 1600 times and 3200 times with purified water and is used as a determination sample solution of a sample.
1.3.2 test drugs:
table 1: drug name, experimental concentration and grouping
1.3.3 antiviral assay of test drugs
(1) Sterile 96-well culture plate, 100. mu.L of 2X 10 concentration was added to each well5cells/mLVeroE6 cells, 5% CO at 37 ℃2Culturing for 24 hours;
(2) adding 100TCID into the culture plate experimental group and the virus control group50100 mu L of virus liquid is added into each hole,37℃，5％CO2adsorbing for 2 hours by an incubator;
(3) after 2 hours, discarding the cell culture solution in the 96-well culture plate; diluting the tested medicine into each concentration in table 1, wherein each concentration is 3 multiple holes, and adding the liquid medicine into each hole with the concentration of 100 mu l;
(4) simultaneously setting a cell control, a blank control (solvent control) and a virus control (negative control);
(5) cell 37 ℃, 5% C02Incubating in an incubator for 3-4 days;
(6) and observing cytopathic effect (CPE) under an optical microscope, and recording the degree of the cytopathic effect according to the following 6-grade standard: "-" no lesions present; "±" means less than 10% cytopathic effect; "+" indicates about 25% cellular pathology; "+ +" indicates about 50% of cellular pathology; "+ + + +" indicates that about 75% of the cells are diseased: "+ ++" indicates that 75% or more of the lesions are diseased. The half maximal effective concentration (IC) was calculated using the Reed-Muench method or GraphPad prism5.050). Judging the drug effect standard: concentrations that inhibit viral CPE by 50% are considered effective concentrations.
1.3.4 Experimental conditions: the above experimental operations are all completed in a BSL-3 laboratory.
1.4, results of the experiment
TABLE 1 results of the pharmacological effects of Red nucleus (batch No. 180802) against the novel coronavirus
The experiment result shows that the Chinese medicinal preparation red nucleus gynecological cleaning lotion (batch No. 180802) of the natural composition has an IC50 value of 743.2 times of dilution for the cytopathic effect of a novel coronavirus (SARS-COV-2) infected Vero E6 cell.
The illustrative embodiments and descriptions of the present invention are provided to explain the present invention and do not constitute a limitation on the present invention, wherein the present invention is a red nucleus feminine wash.
Detailed Description
The following are specific examples of the present disclosure, which are used to illustrate technical solutions to be solved in the present disclosure and help those skilled in the art understand the present disclosure, but the present disclosure is not limited to these examples.
EXAMPLE 1 preparation and use of solution A of the Natural composition of the invention
Weighing 7g of hawthorn seed dry distillation oil and 15g of hawthorn seed dry distillation liquid, adding purified water to 1000ml, stirring uniformly, standing, and filtering to obtain the product.
The solution is used as a washing solution for washing food.
The food for killing comprises the following components: pork, beef, mutton, chicken, duck, goose, fish, mollusk, animal bone, animal cartilage, dairy, sausage, hot dog, smoked sausage, roasted sausage, casing, etc.
EXAMPLE 2 preparation and use of solution B of the Natural composition according to the invention
Weighing 7g of hawthorn seed dry distillation oil, 15g of hawthorn seed dry distillation liquid, a proper amount of glycerol and lauric acid, adding purified water to 1000ml, stirring and uniformly mixing, standing, and filtering to obtain the hawthorn seed dry distillation oil.
The application is the same as example 1.
EXAMPLE 3 preparation and use of solution C of the Natural composition of the invention
Weighing 7g of hawthorn seed dry distillation oil, 15g of hawthorn seed dry distillation liquid and a proper amount of glycerol, adding purified water to 1000ml, stirring and uniformly mixing, standing, and filtering to obtain the hawthorn seed dry distillation oil.
The application is the same as example 1.
EXAMPLE 4 preparation and use of solution C of the Natural composition of the invention
Weighing 7g of hawthorn seed dry distillation oil, 15g of hawthorn seed dry distillation liquid, a proper amount of propylene glycol and sodium dodecyl sulfate, adding purified water to 1000ml, stirring uniformly, standing, and filtering to obtain the product.
The application is the same as example 1.
EXAMPLE 5 preparation and use of solution D of the Natural composition of the invention
Weighing 7g of hawthorn seed dry distillation oil, 15g of hawthorn seed dry distillation liquid, sodium alginate, carbomer and the like, adding purified water to 1000ml, stirring uniformly, standing, and filtering to obtain the product.
The application is the same as example 1.
EXAMPLE 6 cleaning solution of Natural composition of the invention preparation method and use
The technical scheme includes that 5g of hawthorn kernel dry distillation oil is placed in a batching cylinder, a 120-mesh screen, 25g of bean phospholipid and 200g of purified water are added, and stirring is carried out for 30 minutes at normal temperature;
20g of hawthorn seed dry distillation liquid is added into the liquid medicine, and the mixture is stirred for 30 minutes at normal temperature;
thirdly, adding 775g of purified water into the liquid medicine, and stirring for 30 minutes at normal temperature;
fourth, the mixed liquid is left to stand for 4 hours and then filtered to prepare a cleaning liquid.
The application is the same as example 1.
EXAMPLE 7 preparation and use of spray A of Natural composition of the invention
Weighing 7g of hawthorn kernel dry distillation oil, 15g of hawthorn kernel dry distillation liquid and 96g of dietary cellulose for later use;
and taking a proper amount of purified water, adding 96g of dietary cellulose, and soaking for 12 hours until the dietary cellulose is completely swelled for later use.
And thirdly, sequentially adding 7g of hawthorn kernel dry distillation oil and 15g of hawthorn kernel dry distillation liquid into the solution obtained in the step 2, stirring while adding, and stirring uniformly.
Fourthly, supplementing purified water to 1000ml, stirring and uniformly mixing, standing, and filtering to obtain the water-based paint.
Spraying the spray on the surface of food, and cleaning the food.
The application is the same as example 1.
EXAMPLE 8 preparation and use of spray B of Natural composition of the invention
Weighing 7g of hawthorn kernel dry distillation oil, 15g of hawthorn kernel dry distillation liquid, 80g of sodium dodecyl sulfate, 160g of glycerol, 8g of sodium benzoate, 8ml of peppermint oil and 96g of carboxymethyl cellulose for later use;
and taking a proper amount of purified water, adding 96g of carboxymethyl cellulose, soaking for 12 hours, and waiting until the carboxymethyl cellulose is completely swelled for later use.
And thirdly, sequentially adding the hawthorn seed extract, the peppermint oil, the sodium dodecyl sulfate, the glycerol and the sodium benzoate into the solution obtained in the step 2, stirring while adding, and uniformly stirring.
And fourthly, supplementing purified water to 1000ml, stirring and uniformly mixing, standing, and filtering to obtain the water-soluble organic silicon dioxide.
Spraying the spray on the surface of food, and cleaning the food.
The application is the same as example 1.
Example 9
Example 9 was 8 solutions, each having a concentration of 10% of the concentration of the solutions of examples 1-8, respectively.
The use is as in example 1.
It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications therefrom are within the scope of the invention.
Claims (9)
1. Use of a natural composition as a disinfectant in blocking the transmission of viruses, characterized in that: the natural composition comprises the following components in percentage by weight: 3-7 parts of hawthorn seed dry distillation oil.
2. Use according to claim 1, characterized in that: the natural composition further comprises: 18-22 parts of hawthorn seed dry distillation liquid.
3. Use according to claim 1 or 2, characterized in that: the propagation pathway includes, but is not limited to, the cold chain.
4. Use according to claim 3, characterized in that: the transmission routes include, but are not limited to, the manufacture, storage, transportation, sale, use of food.
5. Use according to claim 1 or 2, characterized in that: the use of said natural composition for the prevention and the disinfection of coronavirus on food.
6. Use according to claim 1 or 2, characterized in that: the natural composition comprises the following components in percentage by weight: 5 parts of hawthorn seed dry distillation oil, 20 parts of hawthorn seed dry distillation liquid, 50 parts of deionized water and a proper amount of food auxiliary materials; the dosage forms are solution, emulsion, gel, spray, aerosol, disinfectant, liniment, and liquid smoke.
7. The use according to claim 6, wherein the natural composition is prepared by a process comprising:
mixing semen crataegi dry distillation oil and semen crataegi dry distillation liquid, adding food grade adjuvants, stirring at room temperature for 20-40 min to obtain mixed solution, standing, and filtering to obtain natural composition;
the natural composition can be in the form of solution, emulsion, fat emulsion, gel, spray, and aerosol.
8. The use according to claim 7, wherein the natural composition is prepared by a process comprising:
the method comprises the steps of putting hawthorn kernel dry distillation oil into a batching cylinder, adding 120-mesh screen food auxiliary materials, and stirring for 30 minutes at normal temperature;
adding the hawthorn kernel dry distillation liquid into the liquid medicine in the step, and stirring for 30 minutes at normal temperature to obtain a mixed liquid A;
adding purified water into the mixed solution obtained in the second step, and stirring at normal temperature for 30 minutes to obtain a mixed solution B;
fourthly, standing the mixed liquid B obtained in the step three for 4 hours, and filtering to obtain the liquid B.
9. Use according to claim 1 or 2, characterized in that: the virus comprises: adenovirus, herpesvirus, poxvirus, reovirus, small DNA virus, togavirus, orthomyxovirus, paramyxovirus, cannonball virus, hepatitis a virus, hepatitis b virus, hepatitis c virus, hepatitis e virus, poliovirus, aids virus, encephalitis b virus, dengue fever virus, yellow fever virus, west nile virus, japanese encephalitis virus, tick-borne encephalitis virus, hemorrhagic fever virus, bovine viral diarrhea virus, zaka virus, measles virus, rabies virus, influenza virus, avian influenza virus, swine influenza virus, ebola virus, rotavirus, coronavirus, SARS virus, MERS virus;
the coronavirus is preferably SARS-COV-2 novel coronavirus.
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| CN112402500A (en) * | 2020-11-20 | 2021-02-26 | 山东步长神州制药有限公司 | Application of traditional Chinese medicine preparation in preventing and killing coronavirus |
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| CN104107237A (en) * | 2014-07-22 | 2014-10-22 | 山东步长神州制药有限公司 | Application of traditional Chinese medicine preparation in preparation of medicines for treating dermatophytosis |
| CN112402500A (en) * | 2020-11-20 | 2021-02-26 | 山东步长神州制药有限公司 | Application of traditional Chinese medicine preparation in preventing and killing coronavirus |
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