CN109601535A - Disinfectant, preparation method and sterilized articles therefrom - Google Patents
Disinfectant, preparation method and sterilized articles therefrom Download PDFInfo
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- CN109601535A CN109601535A CN201811649180.0A CN201811649180A CN109601535A CN 109601535 A CN109601535 A CN 109601535A CN 201811649180 A CN201811649180 A CN 201811649180A CN 109601535 A CN109601535 A CN 109601535A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/12—Iodine, e.g. iodophors; Compounds thereof
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Abstract
Disinfectant, preparation method and sterilized articles therefrom belong to disinfection technology field.Disinfectant raw material includes: the water of quaternary ammonium salt 0.1-0.4%, iodine 0.1-0.3%, potassium iodide 1-3%, nonionic surfactant 0.2-2% and surplus by mass percentage.The preparation method of disinfectant includes that the other compositions in the raw material by disinfectant other than water are dissolved in water.Sterilized articles therefrom includes the disinfection ontology for being impregnated with disinfectant.Disinfectant uses iodine, quaternary ammonium salt disinfection and sterilization；Nonionic surfactant can directly adopt water as solvent as cosolvent；Quaternary ammonium salt and nonionic surfactant can also be competed to be complexed with iodine, and the efficiency time of iodine is long, irritation is small, bactericidal effect is good.Guarantee that disinfectant is nonirritant, have no toxic side effect, without allergic reaction, the germ virus for killing skin, mucous membrane, wound can be directly used in, can easily and timely be used for wound emergency processing.Preparation method is simple, and it is easy to use to be prepared into various sterilized articles therefroms.
Description
Technical field
The present invention relates to disinfection technology fields, in particular to a kind of disinfectant, preparation method and sterilized articles therefrom.
Background technique
Rabies can anti-uncurable disease, " rabies exposure prevention and disposition specification (2009 editions) " hereinafter referred to as " specification " provide:
After rabies exposure by doctor be determined as II grades and III level exposure should carry out immediately treatment of wounds, inoculation rabies vaccine and
Passive immunity preparation.Treatment of wounds includes cleaning down and disinfection treatment, wound irrigation should with 20% suds (or weak base
Property detergent) and a large amount of clear water alternately rinse all places 15 minutes or more of scratching and bite." rabies prophylaxis control technique guideline
(2016 editions) " in regulation: wound irrigation will use suds (or other alkalescent cleaning agents) and certain pressure flowing clear water
Alternately rinse the every place's wound for biting or scratching, at least 15 minutes.Such as conditions permit, it is proposed that use rabies professional cleaning equipment
Wound inside is rinsed with scavenger specially, finally uses normal saline flushing wound.
However, 20% suds (or alkalescent detergent) are not easy to configure and be not the doctor of standard in above-mentioned " specification "
Product is treated, and cannot be used for skin and mucous membrane disinfection, needs to special dog to hurt outpatient service using special equipment and carries out wound
Reason, causes to kill in virus of the first time to wound, virtually increases infection risk.Therefore, it is necessary to one
Kind it is used directly for the disinfectant of wound disinfection, when application is nonirritant to skin and mucosa, has no toxic side effect, is anti-without allergy
It answers, can quickly kill rabies viruses, make voluntarily to carry out disinfection to wound using disinfectant in the first time bitten, then arrive
Special dog hurts outpatient service and carries out treatment of wounds, reduces infection risk.
Summary of the invention
It is an object of the invention at least solve an above-mentioned technical problem, a kind of disinfectant, preparation method are provided
And sterilized articles therefrom, disinfectant is nonirritant, has no toxic side effect, without allergic reaction, can be directly used for killing skin, mucous membrane, wound
The germ of mouth and virus can facilitate, be used for wound emergency processing in time.
The embodiment of the present invention is achieved in that
In a first aspect, the embodiment of the present invention provides a kind of disinfectant, raw material includes: quaternary ammonium salt by mass percentage
The water of 0.1-0.4%, iodine 0.1-0.3%, potassium iodide 1-3%, nonionic surfactant 0.2-2% and surplus.
In above-mentioned technical proposal, iodine can be destroyed cellulosa by iodination, be can be widely applied to skin, glued
The disinfection of film, instrument, article.Inventor the study found that iodine work fast, but efficiency time it is short, to skin pierce
It is strong to swash property, and adds potassium iodide in disinfectant, reversible reaction occurs for elemental iodine and potassium iodide, is on the one hand conducive to elemental iodine and exists
It is sufficiently dissolved in water, on the other hand also helps to a certain extent and increase efficiency time, reduce the irritation to skin.In order to
Further overcome the above problem, adds quaternary ammonium salt in disinfectant and nonionic surfactant is mutually coordinated.Quaternary ammonium salt, a side
For face, there is excellent antibacterial, bactericidal property；For another aspect, as cationic surfactant, the macromolecular substances
Complexing can be carried out to iodine, efficiency time can be effectively improved, but studied through inventor and find that the complexing obtains
To complex compound free-iodine be not easy release and sterilization speed it is slower.Nonionic surfactant also can be used in carrying out network with iodine
It closes, the irritation for the complex compound being complexed is small, but there are still the problems that free-iodine rate of release is slow, sterilizing ability is weak.
And applicant further study show that, while adding quaternary ammonium salt and nonionic surfactant, quaternary ammonium salt and non-ionic surface are living
Property agent compete carry out complexing with iodine between each other, weaken the respectively binding force to iodine thus opposite, be conducive to free-iodine
Release, to ensure that disinfectant is provided simultaneously with the property such as irritation is small, aging time is long, disinfection and sterilization speed is fast and effect is good
Energy.Meanwhile nonionic surfactant can also be used as cosolvent in disinfectant, make disinfectant that water can be directly used as molten
Agent, without organic solvents such as alcohols as solvent, the nonirritant, presence that has no toxic side effect, while avoiding alcohol etc. and
Lead to allergic reaction.So that disinfectant provided by the embodiments of the present application can be directly used for killing the germ of skin, mucous membrane, wound
And virus, it can facilitate, be used for wound emergency processing in time.
In some optional embodiments, raw material includes: quaternary ammonium salt 0.2-0.3%, iodine 0.15- by mass percentage
0.25%, the water of potassium iodide 1.5-2.5%, nonionic surfactant 0.5-1.5% and surplus.
In above-mentioned technical proposal, each component is configured according to aforementioned proportion, it is mutually coordinated between component, it can play
More preferably, milder, more longlasting long-acting sterilization.
In some optional embodiments, quaternary ammonium salt is selected from least one of single-stranded quaternary ammonium salt and double-chain quaternary ammonium salt；
Optionally, single-stranded quaternary ammonium salt is benzalkonium chloride, and double-chain quaternary ammonium salt is double-track suspended self-propelled conveyor.
In above-mentioned technical proposal, in quaternary ammonium salt, the sterilizing of single-stranded quaternary ammonium salt and double-chain quaternary ammonium salt is had excellent performance, can
Play preferable disinfection effect.Benzalkonium chloride in single-stranded quaternary ammonium salt has wide spectrum, efficient sterilizing ability, and has
There are good dispersion and osmosis, the double-track suspended self-propelled conveyor in double-chain quaternary ammonium salt also shows good sterilizing
Effect is conducive to the sterilizing effect for playing quaternary ammonium salt.
In some optional embodiments, quaternary ammonium salt includes single-stranded quaternary ammonium salt and double-chain quaternary ammonium salt；Optionally, single-stranded season
Mass percent of the ammonium salt in quaternary ammonium salt is 30-60%.
In above-mentioned technical proposal, since single-stranded quaternary ammonium salt can only kill certain bacterial propagules and fat eliminating virus, double-strand season
Ammonium salt can then kill multiple-microorganism, including bacterial propagule, fungi and virus.Matched using single-stranded quaternary ammonium salt and double-chain quaternary ammonium salt
It closes and coordinates, more comprehensively, sterilization effect is more preferably for the microbe species that kill it can.Single-stranded quaternary ammonium salt and double-chain quaternary ammonium salt are pressed
It is configured according to aforementioned proportion, coordinative role between the two is more preferable, is conducive to the sterilization for giving full play to its compounding.
And inventor, the study found that when using benzalkonium chloride and mutually coordinated double-track suspended self-propelled conveyor, disinfectant is shown
Excellent disinfection, bactericidal effect, while being conducive to improve stability of the benzalkonium chloride in the disinfectant.
In some optional embodiments, it is poly- that nonionic surfactant is selected from fatty alcohol polyoxyethylene ether, alkyl phenol
In ethylene oxide ether, polyoxyethylene carboxylate, fatty acid methyl ester ethoxylate, sorbitan ester and alkylolamides extremely
Few one kind；Optionally, nonionic surfactant is polyoxyethylene carboxylate.
In above-mentioned technical proposal, above-mentioned each nonionic surfactant is provided with that good stability, irritation be small, toxic side effect
Small feature, and match with competitiveness of the quaternary ammonium salt to the complexing of iodine, making the rate of release of free-iodine is suitable for advantageously ensuring that
Disinfectant is efficient, long-acting, stable, non-stimulated, effect for having no toxic side effect etc..And the non-ionic surface active optionally uses rouge
When fat acid polyoxyethylene ester, competition coordination harmony to iodine and to the peptizaiton of solute more preferably.
In some optional embodiments, raw material is by mass percentage further include: antiviral synergist 0.1-
0.5%；It optionally, further include antiviral synergist 0.2-0.4%.
In above-mentioned technical proposal, synergist of the antiviral synergist as disinfectant can effectively enhance disinfectant
Antivirus effect, standby spy is when being applied to carry out disinfection to dog wound, can quickly and efficiently to kill virus, further decrease infection
Risk.
In some optional embodiments, antiviral synergist be selected from iodoxuridine, trifluorothymidine, phthiobuzonum, acyclovir,
At least one of Penciclovir and Ribavirin；Optionally, antiviral synergist is trifluorothymidine.
In above-mentioned technical proposal, the antiviral synergist of mentioned kind is selected, preferable antivirus action is all had.It is optional
Using trifluorothymidine when, it is good with the harmony of other components in disinfectant, ensure that the stability of disinfectant and efficiently disappear
Malicious bactericidal effect.
Second aspect, the embodiment of the present invention provide a kind of preparation method of disinfectant that first aspect embodiment provides,
Other compositions in raw material including the disinfectant for providing first aspect embodiment other than water are dissolved in water.
In above-mentioned technical proposal, each solute in raw material mixes in water can be sufficiently carried out complex reaction and dissolution
Dispersion, the preparation method is simple, is convenient for large-scale industrial production.Without the operation such as heating in preparation, effective component is avoided to exist
It is lost or is denaturalized in heating process, be able to maintain the high-effective disinfecting bactericidal effect of disinfectant.
In some optional embodiments, dissolution operation includes: that potassium iodide is dissolved in the water of part to obtain iodate
Iodine is dissolved in liquor kalii iodide and obtains iodine solution by potassium solution, and the residual components other than water in raw material are stirred in iodine solution
It is mixed after mixing mixing with remaining water.
In above-mentioned technical proposal, elemental iodine is dissolved in liquor kalii iodide, is conducive to elemental iodine and sufficiently dissolves, to iodine list
Matter after completely dissolution, adds quaternary ammonium salt, nonionic surfactant etc., and iodine is enable sufficiently to be complexed, and makes point of thimerosal
Scattered property is good, homogeneous and stability is good, is conducive to the quality for improving disinfectant.
The third aspect, the embodiment of the present invention provide a kind of sterilized articles therefrom comprising are impregnated with the offer of first aspect embodiment
Disinfectant disinfection ontology；Optionally, sterilized articles therefrom is selected from disinfecting cotton swab, sterilized cotton ball, pasteurization towelette, disinfection pad, disappears
Malicious dressing and contain be impregnated with disinfectant disinfection ontology sterile package.
In above-mentioned technical proposal, disinfectant is infiltrated on disinfection ontology and being packaged into and is suitble to different usage scenarios, using needing
The sterilized articles therefrom asked directly buys use convenient for user, easy to use.
Specific embodiment
It in order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below will be in the embodiment of the present invention
Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, according to normal conditions or manufacturer builds
The condition of view carries out.Reagents or instruments used without specified manufacturer is the conventional production that can be obtained by commercially available purchase
Product.
The disinfectant of the embodiment of the present invention, preparation method and sterilized articles therefrom are specifically described below.
In a first aspect, the embodiment of the present invention provides a kind of disinfectant, raw material includes: quaternary ammonium salt by mass percentage
The water of 0.1-0.4%, iodine 0.1-0.3%, potassium iodide 1-3%, nonionic surfactant 0.2-2% and surplus.
Optionally, the raw material of disinfectant is by mass percentage further include: antiviral synergist 0.1-0.5%.It can increase
The strong antiviral effect of disinfectant is further dropped especially suitable for handling animal bite, the disinfection and sterilization for the wounds such as scratching
Low infection risk.
In some specific embodiments, the mass percent of quaternary ammonium salt in the feed is optionally 0.2-0.4%, or
0.1-0.3% or 0.2-0.3%, such as, but not limited to 0.1%, 0.2%, 0.3%, 0.4%.Iodine in the present embodiment refers to
Elemental iodine, the mass percent of iodine in the feed are optionally 0.2-0.3% or 0.1-0.2%, such as, but not limited to 0.1%,
0.2%, 0.3%.Mass percent is optionally 1-2% or 2-3% to potassium iodide in the feed, such as, but not limited to 1%,
2%, 3%.The mass percent of nonionic surfactant in the feed is optionally 0.2-2% or 0.2-1.5%, or
0.5-2% or 0.5-1.5%, such as, but not limited to 0.2%, 0.5%, 0.8%, 1%, 1.2%, 1.5%, 1.8%, 2%.
The optional 0.1-0.4% of the mass percent of antiviral synergist in the feed or 0.2-0.5%, 0.2-0.4%, such as but
It is not limited to 0.1%, 0.2%, 0.3%, 0.4%, 0.5%.
The type of quaternary ammonium salt is not especially limited, as long as the conventional type that can apply to sterilizing, such as
Quaternary ammonium salt is optionally one of single-stranded quaternary ammonium salt, double-chain quaternary ammonium salt, mixing quaternary ammonium salt etc. or a variety of.Additionally need explanation
It is a variety of in the application, the case where each meaning at least two.
In some specific embodiments, quaternary ammonium salt is selected from least one of single-stranded quaternary ammonium salt and double-chain quaternary ammonium salt, example
It such as can be with: being made of at least one single-stranded quaternary ammonium salt；It is made of at least one double-chain quaternary ammonium salt；Or by least one single-stranded season
Ammonium salt and at least one double-chain quaternary ammonium salt collectively constitute, and optionally, mass percent of the single-stranded quaternary ammonium salt in quaternary ammonium salt is 30-
60% or 40-60%, such as, but not limited to 30%, 40%, 50%, 60%.
Single-stranded quaternary ammonium salt is optionally the mixed of any one or any multiple combinations in alkyl dimethyl benzyl ammonium halide
Close object.The alkyl dimethyl benzyl ammonium halide is optionally chloride, bromide, such as dodecyl dimethyl Benzylmagnesium chloride
Ammonium, myristyl benzyl dimethyl ammonium chloride, cetalkonium chloride, octadecyl dimethyl benzyl chlorination
Ammonium, dodecyl dimethyl benzyl ammonium bromide, tetradecyl dimethyl benzyl ammonium, hexadecyldimethyl benzyl ammonium Benzylphosphonium Bromide
Ammonium, octadecyl dimethyl benzyl ammonium bromide, dodecyl trimethyl ammonium chloride, tetradecyl trimethyl ammonium chloride, hexadecane
Base trimethyl ammonium chloride, octadecyltrimethylammonium chloride, dodecyl trimethyl ammonium bromide, tetradecyltrimethylammonium bromination
The mixing of any one or any multiple combinations in ammonium, cetyl trimethylammonium bromide and Cetyltrimethylammonium bromide
Object.
Double-chain quaternary ammonium salt is optionally double octyl quaternary ammonium salts, double decyl quaternary ammonium salts, double dodecyl quaternary ammonium salts and the octyl last of the ten Heavenly stems
The mixture of any one or any multiple combinations in based quaternary ammonium salt.Further alternative is double decyl quaternary ammonium salts, such as double
One or both of decyl dimethyl ammonium bromide, double-track suspended self-propelled conveyor.
In a specific embodiment, quaternary ammonium salt is made of benzalkonium chloride and double-track suspended self-propelled conveyor.Specifically exist
In one specific embodiment, such as quaternary ammonium salt is by the mass ratio substantially benzalkonium chloride of 1:1 and double-track suspended self-propelled conveyor
Composition.
The type of nonionic surfactant is not especially limited, and the standard of selection is: in water to other components
There is preferable hydrotropy solution, and suitable with the ability of quaternary ammonium salt competitive binding free-iodine.In some specific embodiments,
Nonionic surfactant is optionally fatty alcohol polyoxyethylene ether, alkyl phenol polyoxyethylene ether, polyoxyethylene carboxylate, rouge
At least one of fatty acid methyl esters ethoxylate, sorbitan ester and alkylolamides, it is such as arbitrary one or more.?
In one specific embodiment, which is polyoxyethylene carboxylate.
Antiviral synergist is optionally using the antiviral agent that can kill the virus such as rabies viruses, poliovirus
Object, type are not especially limited.In some alternative embodiments, antiviral synergist is selected from iodoxuridine, trifluorothymidine, phthalein fourth
At least one of peace, acyclovir, Penciclovir and Ribavirin, it is such as arbitrary one or more.It is specific real at one
It applies in example, which is trifluorothymidine.
In addition, the water in raw material uses deionized water, and impurity content is low, avoids water in some specific embodiments
In metal ion etc. complexing, flocculation etc. occurs with the ingredient in solution, keep the disinfectant Activity and stabill being configured to high.
Above-mentioned disinfectant can be used for killing virus and the bacterium of skin, mucous membrane, wound and body surface, be applied to kill
The virus gone out includes: rabies viruses, poliovirus.According to different use requirements, disinfectant is optionally produced as not
The bottled medicament of same specification size, packaged form are for example produced as wide-mouth bottle medicament or medicament or band with pressing extruder head
There is the spray of spray head, can adapt in different service conditions.
Second aspect, the embodiment of the present invention provide a kind of preparation method of disinfectant that first aspect embodiment provides,
Other compositions in raw material including the disinfectant for providing first aspect embodiment other than water are dissolved in water.
Other compositions (hereinafter referred to as solute) in the raw material of above-mentioned disinfectant other than water refer to: quaternary ammonium salt, iodine, potassium iodide
And nonionic surfactant, in the feed including also including the antiviral synergist in the case where antiviral synergist.This is molten
The charging sequence of solution operation, mixing method are not specifically limited, as long as solute can be made to be completely dissolved in water.In addition,
It should be noted that above-mentioned described solute is dissolved in the water, it further include by the Dispersion of Solute Matter of the undissolved Yu Shuizhong in few part
Yu Shuizhong.
In order to enable iodine sufficiently to dissolve, potassium iodide is first optionally configured to liquor kalii iodide, is then dissolved in iodine
In liquor kalii iodide, add quaternary ammonium salt, nonionic surfactant be sufficiently stirred a period of time make iodine and macromolecular progress network
It closes.Antiviral synergist is optionally added in solution together with quaternary ammonium salt, nonionic surfactant, or prior to, after in quaternary ammonium
Salt, nonionic surfactant are added in solution, as long as can sufficiently dissolve.
In some specific embodiments, dissolution operation includes: that potassium iodide is dissolved in the water of part to obtain potassium iodide
Solution.Iodine is dissolved in liquor kalii iodide and obtains iodine solution, the residual components other than water in raw material are stirred in iodine solution
Mixing.Optionally, when quaternary ammonium salt is mixture, before quaternary ammonium salt is added, first various quaternary ammonium salt is mixed
The quaternary ammonium salt of conjunction disperses various quaternary ammonium salt between each other more evenly, and more preferably, stability of solution is more preferable for coordinative role.In order to make
Iodine is sufficiently complexed, and optionally, the time being stirred optionally is about 1-2h, such as 1h, 1.5h, 2h.It is stirred and fills
Remaining water is added after point to mix.
In order to enable iodine sufficiently to dissolve and be complexed, while reducing manipulation strength when solution stirring, in some realities
It applies in example, potassium iodide is dissolved in the operation of water, to obtain the potassium iodide that mass concentration is about 30% molten according to configuration for water consumption
The standard of liquid is taken, and is 25-35% as configured the obtained mass concentration of liquor kalii iodide, such as, but not limited to 25%, 28%,
30%, 32%, 35%.
Further, in some embodiments, after iodine is dissolved in liquor kalii iodide, remaining component is according to following
Method sequentially adds.Specifically, quaternary ammonium salt is first added, nonionic surfactant is then added, when also contain antiviral synergy
Antiviral synergist is eventually adding when agent.The above-mentioned sequence successively added of quaternary ammonium salt and nonionic surfactant makes the two
Between have preferable competition coordination state, avoid the complexing degree of nonionic surfactant and iodine excessive, make disinfectant
The rate of release of used time iodine is appropriate.And antiviral synergist is finally added, it can be in the hydrotropy of nonionic surfactant
It sufficiently dissolves and is uniformly dispersed under effect.
After the completion of disinfectant is prepared, is dispensed, stored.The bottle of packing is washed, is dried, in clean environment
It is lower to dispense the upper obtained disinfectant prepared according to design specification, mounted box and shady and cool dry place's preservation is put into after packing.
The third aspect, the embodiment of the present invention provide a kind of sterilized articles therefrom comprising are impregnated with the offer of first aspect embodiment
Disinfectant disinfection ontology.
Disinfection ontology, which refers to, can directly act on the article for contacting position to be sterilized, conduct in disinfection and sterilization operation
The carrier of disinfectant can be the form that agent carrier is commonly sterilized in sterilizing operation, such as cotton swab, cotton balls, cotton piece, wiping cloth
Deng not doing specific restriction to its type.Sterilized articles therefrom refers to that by disinfectant, to be infiltrated on disinfection ontology in advance in production enterprising
The seal-packed product form of row can be used directly convenient for consumer in purchase, be can be disinfection common on the market and produced
The form of product.
In some specific embodiments, sterilized articles therefrom is for example selected from disinfecting cotton swab, sterilized cotton ball, pasteurization towelette, disinfection
Pad, aseptic dressing and the sterile package containing the disinfection ontology for being impregnated with disinfectant.The disinfection of disinfectant is impregnated in sterile package
Ontology is optionally any one or more in disinfecting cotton swab, sterilized cotton ball, pasteurization towelette, disinfection pad, aseptic dressing etc.,
In addition to this, sterile package optionally further includes some conventional disposable sterilization apparatus, such as disposable Medical forceps,
Gloves, pallet etc..
Feature and performance of the invention are described in further detail with reference to embodiments.
Embodiment 1-5 and comparative example 1-4
A kind of disinfectant, raw material composition and mass percent are as shown in table 1.Preparation method includes: that potassium iodide is molten
Solution in the deionized water of part, is configured to liquor kalii iodide in raw material.Iodine is dissolved in liquor kalii iodide, it is molten to be configured to iodine
Liquid.Uniformly mixed quaternary ammonium salt, nonionic surfactant and antiviral synergist are sequentially added, after stirring 1h, is added remaining
The deionized water of amount is uniformly mixed.
1 raw material of table composition and mass percent (wt%)
Test example
The property of disinfectant provided by the above embodiment is detected, it is 50ml/ bottles that each embodiment takes specification respectively
15 bottles of medicament.
One, physicochemical property
1, the color of disinfectant is observed.
2, detecting the available iodine content average value of each group disinfectant is about 0.218% (W/W), and quaternary ammonium salt content average value is about
For 0.217% (W/W), pH value average value is about 3.50.After 37 DEG C of insulating box constant temperature save 3 months, detection each group disinfectant
Available iodine content average value is about 0.204% (W/W), and rate of descent is about 6.42% compared with before preservation, and quaternary ammonium salt content is average
Value is about 0.214% (W/W), and rate of descent is about 1.38% compared with before preservation.Meet " disinfection technology standard " (version in 2002)
Storage period is set to requirement in 2 years.
In above-mentioned content detection, the assay (in terms of benzalkonium chloride, g/L) of quaternary ammonium salt, according to " quaternary ammonium disinfectant
Sanitary standard " (GB26369-2010), it is measured under 25 DEG C of -45% relative humidity.Same sample, replication twice, as a result
It is averaged.
3, lead content average value < 12.5 μ g/L, arsenic content average value < 50 μ g/L, mercury content for detecting each group disinfectant are flat
Mean value < 1.25ug/L.Content of beary metal is qualified.
Above-mentioned heavy metal limit " qualification ": refer to and meet " skin antiseptic hygienic requirements " (GB27951-2011) and " stick
Film sterilize General Requirement " (GB27954-2011) regulation.
Two, Germicidal Efficacy
1, every group of disinfectant is tested through 3 repetitions, used containing in 50%D/E and the PBS of meat soup (phosphate buffer
Saline, phosphate buffered saline solution) neutralization agent solution can effectively neutralize thimerosal stoste, and neutralize agent solution and neutralized reaction product
Solution is to the growth of staphylococcus aureus, Candida albicans, poliovirus I type vaccine strain and cell substantially without shadow
It rings.
2, it is tested through 3 repetitions, using thimerosal stoste, acts on 1.0min, embodiment 1-5, comparative example 1,2,4, to outstanding
The average killing logarithm of staphylococcus aureus, Escherichia coli and pseudomonas aeruginosa is substantially all > 5.00 in liquid.
3, it is tested through 3 repetitions, using thimerosal stoste, acts on 3.0min, embodiment 1-5, comparative example 1,2,4, to outstanding
The average inactivation logarithm of poliovirus I type vaccine strain is substantially all > 4.0 in liquid.
In above-mentioned detection, the measurement of logarithm is sterilized: being tested according to " disinfection technology standard " (version in 2002).And it examines
Surveying result is that each group disinfectant meets the qualified regulation of " disinfection technology standard " (version in 2002) disinfection substantially.
Three, skin degerming field test
Every group of disinfectant proves that thimerosal stoste acts on 1.0min, to the natural bacteria of skin surface through 30 sampling tests
Averagely kill logarithm > 1.00.Meet the qualified regulation of " disinfection technology standard " (version in 2002) disinfection.
Four, toxicology test
1, each group thimerosal animal during acute oral toxicity test does not occur obvious poisoning symptom and death.It is tested
Object is to female, male Mouse Acute Toxicity LD50 > 5000mg/kg weight.The toxicity of embodiment 1-5 and comparative example 2-4 each group thimerosal
It is classified the true nontoxic grade in border.
2. each group thimerosal stoste carries out Rabbits with Acute eye irritant test, according to " disinfection technology standard " (version in 2002)
2.3.4 acute eye irritation test carries out.The excitatory reaction grade scale of eye, corneal injury < 1, iris damage < 1, conjunctival congestion <
2, chemosis <, testing result determines that the tested material embodiment 1-5 and comparative example 2 are nothing to the type of impairment of rabbit eyes
Irritation.
3. each group thimerosal stoste carries out damaged skin irritant test of rabbit, according to " disinfection technology standard " (2002
Year version) standards of grading, highest skin irritation index is 0 (0- < 0.5), and embodiment 1-5 and 2 stimulus intensity of comparative example belong to stingless
Swash property.
The detection of above-mentioned properties as a result, each embodiment group and the corresponding specific testing result such as following table of comparative example group
Shown in 2.
2 disinfectant nature examination of table
According to table 2, each group disinfectant provided in an embodiment of the present invention all has effective killing logarithm, while right
There is no stimulate the reaction in skin, and have good stability, have effects that while cleaning and sterilizing wound.
In conclusion the disinfectant of the embodiment of the present invention, preparation method and sterilized articles therefrom, disinfectant uses iodine, quaternary ammonium
Salt disinfection and sterilization；Nonionic surfactant can directly adopt water as solvent as cosolvent；Quaternary ammonium salt and non-ionic surface
Activating agent can also be competed to be complexed with iodine, and the efficiency time of iodine is long, irritation is small, bactericidal effect is good.Guarantee that the disinfectant is stingless
Swash property, have no toxic side effect, without allergic reaction, the germ virus for killing skin, mucous membrane, wound can be directly used in, can conveniently and
When be used for wound emergency processing.Preparation method is simple, and it is easy to use to be prepared into various sterilized articles therefroms.
Embodiments described above is a part of the embodiment of the present invention, instead of all the embodiments.Reality of the invention
The detailed description for applying example is not intended to limit the range of claimed invention, but is merely representative of selected implementation of the invention
Example.Based on the embodiments of the present invention, obtained by those of ordinary skill in the art without making creative efforts
Every other embodiment, shall fall within the protection scope of the present invention.
Claims (10)
1. a kind of disinfectant, which is characterized in that its raw material includes: quaternary ammonium salt 0.1-0.4%, iodine 0.1- by mass percentage
0.3%, the water of potassium iodide 1-3%, nonionic surfactant 0.2-2% and surplus.
2. disinfectant according to claim 1, which is characterized in that the raw material includes: the season by mass percentage
Ammonium salt 0.2-0.3%, the iodine 0.15-0.25%, the potassium iodide 1.5-2.5%, the nonionic surfactant 0.5-
1.5% and surplus water.
3. disinfectant according to claim 1 or 2, which is characterized in that the quaternary ammonium salt is selected from single-stranded quaternary ammonium salt and double-strand
At least one of quaternary ammonium salt；Optionally, the single-stranded quaternary ammonium salt is benzalkonium chloride, and the double-chain quaternary ammonium salt is double decyl dimethyls
Ammonium chloride.
4. disinfectant according to claim 3, which is characterized in that the quaternary ammonium salt includes the single-stranded quaternary ammonium salt and described
Double-chain quaternary ammonium salt；Optionally, mass percent of the single-stranded quaternary ammonium salt in the quaternary ammonium salt is 30-60%.
5. disinfectant according to claim 1 or 2, which is characterized in that the nonionic surfactant is selected from fatty alcohol
Polyoxyethylene ether, alkyl phenol polyoxyethylene ether, polyoxyethylene carboxylate, fatty acid methyl ester ethoxylate, anhydrous sorbitol
At least one of ester and alkylolamides；Optionally, the nonionic surfactant is polyoxyethylene carboxylate.
6. disinfectant according to claim 1 or 2, which is characterized in that the raw material is by mass percentage further include: anti-
Virus synergy agent 0.1-0.5%；It optionally, further include the antiviral synergist 0.2-0.4%.
7. disinfectant according to claim 6, which is characterized in that the antiviral synergist be selected from iodoxuridine, trifluorothymidine,
At least one of phthiobuzonum, acyclovir, Penciclovir and Ribavirin；Optionally, the antiviral synergist is trifluoro
Thymidine.
8. the preparation method of the described in any item disinfectants of claim 1-7, characterized in that it comprises: will be in the raw material
Other compositions other than the water are dissolved in the water.
9. the preparation method of disinfectant according to claim 8, which is characterized in that dissolution operation includes: by the iodate
Potassium is dissolved in the water of part and obtains liquor kalii iodide, and the iodine is dissolved in the liquor kalii iodide to obtain iodine molten
Liquid mixes after being stirred the residual components other than water described in the raw material in the iodine solution with the remaining water
It is even.
10. a kind of sterilized articles therefrom, which is characterized in that it includes being impregnated with disappearing for the described in any item disinfectants of claim 1-7
Malicious ontology；Optionally, the sterilized articles therefrom be selected from disinfecting cotton swab, sterilized cotton ball, pasteurization towelette, disinfection pad, aseptic dressing and
Sterile package containing the disinfection ontology for being impregnated with the disinfectant.
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| CN201811649180.0A CN109601535A (en) | 2018-12-30 | 2018-12-30 | Disinfectant, preparation method and sterilized articles therefrom |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112806386A (en) * | 2020-12-30 | 2021-05-18 | 佛山市正典生物技术有限公司 | Disinfectant containing iodine complex and preparation method thereof |
| CN113018257A (en) * | 2021-03-03 | 2021-06-25 | 西安蓝茗医疗科技有限公司 | Alkalescent skin mucosa cleaning disinfectant and preparation method thereof |
| CN113632803A (en) * | 2020-04-27 | 2021-11-12 | 瑞普（天津）生物药业有限公司 | Quaternary ammonium salt complex iodine disinfectant and preparation method thereof |
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| CN103766399A (en) * | 2012-10-22 | 2014-05-07 | 洛阳惠中兽药有限公司 | Iodine-containing disinfectant and preparation method thereof |
| CN104055790A (en) * | 2014-06-24 | 2014-09-24 | 中国人民解放军疾病预防控制所 | Compound skin mucous membrane disinfectant, preparation method and application thereof |
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| CN102488705A (en) * | 2011-12-08 | 2012-06-13 | 施耐克江苏生物制药有限公司 | Skin mucous membrane disinfectant for killing virus |
| CN102600496A (en) * | 2012-01-30 | 2012-07-25 | 施耐克江苏生物制药有限公司 | I, II and III medical equipment products acting on skin, mucosa and wound for inactivating virus |
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| CN113632803A (en) * | 2020-04-27 | 2021-11-12 | 瑞普（天津）生物药业有限公司 | Quaternary ammonium salt complex iodine disinfectant and preparation method thereof |
| CN113632803B (en) * | 2020-04-27 | 2023-06-20 | 瑞普（天津）生物药业有限公司 | Quaternary ammonium salt complex iodine disinfectant and preparation method thereof |
| CN112806386A (en) * | 2020-12-30 | 2021-05-18 | 佛山市正典生物技术有限公司 | Disinfectant containing iodine complex and preparation method thereof |
| CN112806386B (en) * | 2020-12-30 | 2022-02-22 | 佛山市正典生物技术有限公司 | Disinfectant containing iodine complex and preparation method thereof |
| CN113018257A (en) * | 2021-03-03 | 2021-06-25 | 西安蓝茗医疗科技有限公司 | Alkalescent skin mucosa cleaning disinfectant and preparation method thereof |
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