CN106879629A - A kind of multi-effective active iodine antibiotic bactericide and preparation method thereof - Google Patents
A kind of multi-effective active iodine antibiotic bactericide and preparation method thereof Download PDFInfo
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- CN106879629A CN106879629A CN201710216319.1A CN201710216319A CN106879629A CN 106879629 A CN106879629 A CN 106879629A CN 201710216319 A CN201710216319 A CN 201710216319A CN 106879629 A CN106879629 A CN 106879629A
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- Prior art keywords
- iodine
- effective active
- antibiotic
- active iodine
- antibiotic bactericide
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/12—Iodine, e.g. iodophors; Compounds thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
- A01N25/10—Macromolecular compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/32—Ingredients for reducing the noxious effect of the active substances to organisms other than pests, e.g. toxicity reducing compositions, self-destructing compositions
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
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- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Inorganic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of multi-effective active iodine antibiotic bactericide, the multi-effective active iodine antibiotic bactericide has good antibiotic and sterilizing performance, silver iodide are first complexed with nonionic surfactant, different from existing simple substance silver antibacterial agent and silver ion antimicrobial agent product, good stability；Iodine acts synergistically with silver iodide, realizes that antibiotic and sterilizing is acted on.Multi-effective active iodine antibiotic bactericide of the invention, it is by each material composition of following weight proportion：Iodine 1 10%, iodate silver complex 1 10%, nonionic surfactant 15 50%, cosolvent 1 10%, solvent 1 20%, pH adjusting agent 0 2%, water adds to 100%.
Description
Technical field
The present invention relates to a kind of antibiotic bactericide and preparation method thereof, more specifically to a kind of multi-effective active iodine antibacterial
Bactericide and preparation method thereof.
Background technology
In recent years, with the progress and the raising of living standards of the people of science and technology, the health care consciousness and peace of people
Full consciousness increasingly strengthens, and the disease caused due to harmful microorganism in environment is more and more universal, thus active development it is various with
People live closely related antibiotic and sterilizing material as study hotspot.Iodine disinfectant is with iodine by main sterilization component is made
Preparation, it be by dissociate I make protein precipitation play bactericidal action a class efficiently, broad-spectrum disinfectant, can quickly kill
Go out the pathogen such as bacterium, gemma, virus, bacteriophage, fungi.Current liquid disinfectant product of the GB product containing iodine, available iodine
Generally all than relatively low, available iodine content is usually less than 3% to content, and GB product only has the content of iodine tincture,strong higher, is effective
Iodine 10%, but because it has the shortcomings that stability is poor, permeability is strong, Yi Ranhuang, so gradually eliminated by market；Market
Upper high concentration iodine-containing disinfectant generally has as a drawback that：Stability is poor, disinfectant excitant is than in larger, bad dispersibility, water
Dissolution velocity is slow, be diluted with water after there is muddy and lamination.Silver iodide are used only as a long time because there is photonasty simultaneously
Developer and the catalyst in increasing rain artificially, are also used for medical industry sometimes.It is oral, local because the unstability of silver iodide
Contact or occupational Long Term Contact this product, can cause topically or systemically silver calmness, occur locally or systemically skin hemachromatosis,
Eye injury, chronic bronchitis etc., therefore seldom used as antiseptic.If can be by the sterilization of iodine and nano silver iodide
Anti-microbial property cooperateed with, develop it is a kind of it is cheap, easy to use, safely and effectively environmental protection antibiotic bactericide then may be used
To solve problems of the prior art.
The content of the invention
It is to provide a kind of multi-effective active iodine antibiotic bactericide that the purpose of the present invention is.The multi-effective active iodine antibiotic bactericide
With good antibiotic and sterilizing performance, silver iodide are first complexed with nonionic surfactant, different from existing elemental silver
Antiseptic and silver ion antimicrobial agent product, good stability；Iodine acts synergistically with silver iodide, realizes that antibiotic and sterilizing is acted on.
Another object of the present invention is to provide the preparation method of above-mentioned multi-effective active iodine antibiotic bactericide.
It is of the invention to be achieved through the following technical solutions：
Multi-effective active iodine antibiotic bactericide of the invention, it is by each material composition of following weight proportion：Iodine 1-10%,
Iodate silver complex 1-10%, nonionic surfactant 15-50%, cosolvent 1-10%, solvent 1-20%, pH adjusting agent 0-
2%, water adds to 100%.
The above-mentioned multi-effective active iodine antibiotic bactericide of the present invention, its further technical scheme is described silver iodide complexing
The preparation method of thing is as follows：Silver nitrate and iodide are added dropwise in nonionic surfactant water-soluble liquid, lucifuge stirring
Nano silver iodide complex compound is obtained after ultrasonically treated.Further technical scheme be described silver nitrate and iodide mole
Than being 0.5~2.0, described iodide are sodium iodide or KI.Further technical scheme can also be at 20-80 DEG C
Under conditions of ultrasonically treated 30 minutes or more time.
The above-mentioned multi-effective active iodine antibiotic bactericide of the present invention, its further technical scheme is also being described nonionic
Surfactant is PVP, AEO, NPE or hydroxypropyl methyl cellulose.
The above-mentioned multi-effective active iodine antibiotic bactericide of the present invention, its further technical scheme is also being described cosolvent
It is sodium iodide or KI.
The above-mentioned multi-effective active iodine antibiotic bactericide of the present invention, its further technical scheme is also being that described solvent is
Propane diols, sorbierite or mannitol.
The above-mentioned multi-effective active iodine antibiotic bactericide of the present invention, its further technical scheme is also being that described pH is adjusted
Agent is the acid of citric acid, lactic acid, tartaric acid, sorbic acid or matrimony vine；Wherein after pH adjusting agent is added, lower its bactericidal effect of pH value is more
Get well, preferably 2-3pH values, bactericidal effect is excellent and dry rot corrosion is small.
The preparation method of the above-mentioned multi-effective active iodine antibiotic bactericide of the present invention, comprises the following steps：
A, nonionic surfactant, partial solvent and part water addition reactor are heated to 45-60 DEG C, maintain stirring
Until all dissolving；
B, again by iodine, cosolvent and pH adjusting agent add reactor, at 45-60 DEG C stirring be completely dissolved it；PH is adjusted
Agent can be added without as needed；
C, again to adding remaining solvent in reactor；
D, again to iodate silver complex is added in reactor, and stir；
E, excess water add constant volume, are uniformly mixed and obtain final product multi-effective active iodine antibiotic bactericide.
Compared with prior art the invention has the advantages that：
The present invention has given full play to cooperateing with for iodine and silver iodide, realizes that antibiotic and sterilizing multiple-effect is acted on；By using green ring
Guarantor's type high molecular surfactant makes silver iodide to stablize and preserves as the carrier of silver iodide, improves effective agi content,
Good anti-bacterial effect；The complexing agent of environmental type high molecular surfactant or iodine, content of iodine is also higher, is greatly improved
Its bactericidal property；Other pH adjusting agent alternative is used, and also has good anti-microbial property when being added without.Solvent and cosolvent
As diluent, it is ensured that even if product is when available iodine content is more than 10%, still with excellent water solubility, so as to solve to add
There are the phenomenons such as muddy, layering in water dilution.Multi-effective active iodine antibiotic bactericide of the invention can be used for livestock and poultry cultivation colony house, device
Tool, body surface, disinfection of drinking water, aquaculture system sterilization, aquaculture disinfecting utensils and aquiculture animal bacteriosis
Prevention and control field；Can be additionally used in prevention, the treatment of the various diseases of green plants.Other preparation method is simple, without three in production process
It is useless to produce, environment will not be caused harm.
Specific embodiment
The preparation method of iodate silver complex is as follows used in embodiment：By the silver nitrate of 100mL 0.5mol/L and
100mL0.5mol/L KIs are added dropwise in 500mL nonionic surfactant water-soluble liquid, after being stirred at 35 DEG C
Ultrasonically treated 1 hour.Nonionic surfactant is PVP, AEO, NPE or hydroxyl
Propyl methocel.
Embodiment 1
The present embodiment is matched：Iodine 5%, iodate silver complex 5%, 30 POVIDONE K 30 BP/USP 90 20%, KI 5%, sorbierite
10%, water adds to full dose.
Prepare 10 liters of multi-effective active iodine antibiotic and sterilizing agent methods of the invention as follows：
A, 2kg PVPs 90,0.4kg sorbierites and 2kg water addition reactor are heated to 50 DEG C, maintain stirring until complete
Dissolve in portion；
B, again by iodine 0.5kg, KI 0.5kg add reactor, at 50 DEG C stirring be completely dissolved it；
C, again to adding remaining sorbierite 0.6kg in reactor；
D, again to iodate silver complex 0.5kg is added in reactor, and stir；
E, excess water 3.5kg add constant volume, are uniformly mixed and obtain final product multi-effective active iodine antibiotic bactericide.
The multi-effective active iodine antibiotic bactericide that the present embodiment is provided is carried out into bacteriostasis rate experiment, its result has stronger resisting
Bacterium characteristic.
Embodiment 2
The present embodiment is matched：Iodine 1%, iodate silver complex 10%, AEO 30%, sodium iodide 10%,
Propane diols 5%, citric acid 1%, water adds to full dose.
Prepare 10 liters of multi-effective active iodine antibiotic and sterilizing agent methods of the invention as follows：
A, 3kg AEOs, 0.2kg propane diols and 2.3kg water addition reactor are heated to 50 DEG C, maintained
Stirring is until all dissolve；
B, again by iodine 0.1kg, sodium iodide 1kg and citric acid 0.1kg add reactor, at 50 DEG C stirring make its completely it is molten
Solution；
C, again to adding remaining propane diols 0.3kg in reactor；
D, again to iodate silver complex 1kg is added in reactor, and stir；
E, excess water 3kg add constant volume, are uniformly mixed and obtain final product multi-effective active iodine antibiotic bactericide.
The multi-effective active iodine antibiotic bactericide of the present embodiment, sterilized test effect shows that iodine concentration is after dilution
5000ppm to test organisms staphylococcus aureus, Escherichia coli, pseudomonas aeruginosa, staphylococcus albus was at 1.5 minutes to 5
Sterilization rate is up to 100% in minute.The iodic disinfecting liquid transdermal stimulation of the present embodiment is tested and shown to no skin irritation, its nothing
Xanthochromia easy cleaning.
Embodiment 3
The present embodiment is matched：Iodine 10%, iodate silver complex 1%, AEO 15%, KI 1% is sweet
Dew alcohol 20%, sorbic acid 1%, water adds to full dose.
Prepare 10 liters of multi-effective active iodine antibiotic and sterilizing agent methods of the invention as follows：
A, by 1.5kg AEOs, 1kg mannitol and 2kg water addition reactor be heated to 60 DEG C, maintain to stir
Mix until all dissolving；
B, again by iodine 1kg, KI 0.1kg and sorbic acid 0.1kg add reactor, at 60 DEG C stirring make its completely it is molten
Solution；
C, again to adding remaining mannitol 1kg in reactor；
D, again to iodate silver complex 0.1kg is added in reactor, and stir；
E, excess water 3.2kg add constant volume, are uniformly mixed and obtain final product multi-effective active iodine antibiotic bactericide.
The multi-effective active iodine antibiotic bactericide that the present embodiment is provided is carried out into bacteriostasis rate experiment, its result has stronger resisting
Bacterium sterilization idiocratic.
Embodiment 4
The present embodiment is matched：Iodine 5%, iodate silver complex 5%, 30 POVIDONE K 30 BP/USP 90 25%, KI 5%, sorbierite
10%, citric acid 2%, water adds to full dose.
Prepare 10 liters of multi-effective active iodine antibiotic and sterilizing agent methods of the invention as follows：
A, 2.5kg PVPs 90,0.5kg sorbierites and 2kg water addition reactor are heated to 45 DEG C, maintain stirring until
All dissolvings；
B, again by iodine 0.5kg, KI 0.5kg add reactor, at 45 DEG C stirring be completely dissolved it；
C, again to adding remaining sorbierite 0.5kg in reactor；
D, again to iodate silver complex 0.5kg is added in reactor, and stir；
E, excess water 1.8kg add constant volume, are uniformly mixed and obtain final product multi-effective active iodine antibiotic bactericide.
The multi-effective active iodine antibiotic bactericide that the present embodiment is provided is carried out into bacteriostasis rate experiment, its result has stronger resisting
Bacterium sterilization idiocratic.
Claims (8)
1. a kind of multi-effective active iodine antibiotic bactericide, it is characterised in that by each material composition of following weight proportion：Iodine 1-10%,
Iodate silver complex 1-10%, nonionic surfactant 15-50%, cosolvent 1-10%, solvent 1-20%, pH adjusting agent 0-
2%, water adds to 100%.
2. multi-effective active iodine antibiotic bactericide according to claim 1, it is characterised in that described iodate silver complex
Preparation method is as follows：Silver nitrate and iodide are added dropwise in nonionic surfactant water-soluble liquid, lucifuge stirring ultrasound
Nano silver iodide complex compound is obtained after treatment.
3. multi-effective active iodine antibiotic bactericide according to claim 2, it is characterised in that described silver nitrate and iodide
Mol ratio be 0.5~2.0, described iodide are sodium iodide or KI.
4. multi-effective active iodine antibiotic bactericide according to claim 1, it is characterised in that described non-ionic surface active
Agent is PVP, AEO, NPE or hydroxypropyl methyl cellulose.
5. multi-effective active iodine antibiotic bactericide according to claim 1, it is characterised in that described cosolvent is sodium iodide
Or KI.
6. multi-effective active iodine antibiotic bactericide according to claim 1, it is characterised in that described solvent is propane diols, mountain
Pears alcohol or mannitol.
7. multi-effective active iodine antibiotic bactericide according to claim 1, it is characterised in that described pH adjusting agent is lemon
The acid of acid, lactic acid, tartaric acid, sorbic acid or matrimony vine.
8. a kind of preparation method of multi-effective active iodine antibiotic bactericide as described in claim 1-8 is any, it is characterised in that bag
Include following steps：
A, nonionic surfactant, partial solvent and part water addition reactor are heated to 45-60 DEG C, maintain stirring until
All dissolvings；
B, again by iodine, cosolvent and pH adjusting agent add reactor, at 45-60 DEG C stirring be completely dissolved it；
C, again to adding remaining solvent in reactor；
D, again to nano silver iodide complex compound is added in reactor, and stir；
E, excess water add constant volume, are uniformly mixed and obtain final product multi-effective active iodine antibiotic bactericide.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710216319.1A CN106879629A (en) | 2017-04-05 | 2017-04-05 | A kind of multi-effective active iodine antibiotic bactericide and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710216319.1A CN106879629A (en) | 2017-04-05 | 2017-04-05 | A kind of multi-effective active iodine antibiotic bactericide and preparation method thereof |
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| CN106879629A true CN106879629A (en) | 2017-06-23 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110128751A (en) * | 2019-05-23 | 2019-08-16 | 浙江金彩新材料有限公司 | A kind of iodine system antibacterial matrices and preparation method thereof |
| CN111358807A (en) * | 2020-04-01 | 2020-07-03 | 赵莹 | Nano-silver modified complex iodine composite dry powder disinfection aerosol and preparation method thereof |
| CN115852555A (en) * | 2022-12-15 | 2023-03-28 | 汕头市大江电子商务有限公司 | Environment-friendly antibacterial carpet and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1673093A (en) * | 2005-03-25 | 2005-09-28 | 吉林大学 | Prepn process of nano silver iodide powder |
| CN103202317A (en) * | 2013-04-16 | 2013-07-17 | 苏州大学 | Silver iodine complexing antibacterial agent and preparation method thereof |
| CN106386853A (en) * | 2016-08-30 | 2017-02-15 | 四川创美克科技有限公司 | Multi-effect active iodine disinfectant as well as preparation method and application thereof |
-
2017
- 2017-04-05 CN CN201710216319.1A patent/CN106879629A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1673093A (en) * | 2005-03-25 | 2005-09-28 | 吉林大学 | Prepn process of nano silver iodide powder |
| CN103202317A (en) * | 2013-04-16 | 2013-07-17 | 苏州大学 | Silver iodine complexing antibacterial agent and preparation method thereof |
| CN106386853A (en) * | 2016-08-30 | 2017-02-15 | 四川创美克科技有限公司 | Multi-effect active iodine disinfectant as well as preparation method and application thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110128751A (en) * | 2019-05-23 | 2019-08-16 | 浙江金彩新材料有限公司 | A kind of iodine system antibacterial matrices and preparation method thereof |
| CN111358807A (en) * | 2020-04-01 | 2020-07-03 | 赵莹 | Nano-silver modified complex iodine composite dry powder disinfection aerosol and preparation method thereof |
| CN115852555A (en) * | 2022-12-15 | 2023-03-28 | 汕头市大江电子商务有限公司 | Environment-friendly antibacterial carpet and preparation method thereof |
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Application publication date: 20170623 |