CN108013072A - Efficient sterilization disinfectant and preparation method thereof - Google Patents
Efficient sterilization disinfectant and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/08—Alkali metal chlorides; Alkaline earth metal chlorides
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/12—Iodine, e.g. iodophors; Compounds thereof
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- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/50—Treatment of water, waste water, or sewage by addition or application of a germicide or by oligodynamic treatment
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- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2103/00—Nature of the water, waste water, sewage or sludge to be treated
- C02F2103/02—Non-contaminated water, e.g. for industrial water supply
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- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2103/00—Nature of the water, waste water, sewage or sludge to be treated
- C02F2103/34—Nature of the water, waste water, sewage or sludge to be treated from industrial activities not provided for in groups C02F2103/12 - C02F2103/32
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- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2303/00—Specific treatment goals
- C02F2303/04—Disinfection
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Abstract
The invention discloses efficient sterilization disinfectant and preparation method thereof, by the efficient sterilizing performance of bromine, iodine, by adding suitable stabilizer, surfactant and synergist, is prepared by ligand complex method and Micellar Solubilization method；Main raw materials in proportion is bromine, surfactant, stabilizer, synergist and deionized water；Or bromine, iodine, surfactant, stabilizer, synergist and deionized water.Product of the present invention is efficient, the composite disinfectant of wide spectrum, safety, can quickly, thoroughly sterilize, and stability is good, and the feature of environmental protection is strong, non-stimulated, safe, is adapted to long-term storage.
Description
Technical field
The present invention relates to daily-use chemical industry and disinfection technology field, and in particular to is used as control of microorganisms in water treatment field
The formula and preparation method of fungicide " bromine volt " and " bromine Iodophor ".
Background technology
At present, it is trend of the times to carry out intensive, scientific, ecological cultivation process, and country has also started to pay much attention to
The sustainable development that environment-friendly type cultivation is combined with the ecological agriculture；Numerous studies show, to realize this sustainable development, must
So to go to change from animal diseases control, production model, production management etc., could realize non-harmful green meat war
Slightly.Here, as the increase of centralization-breeding factory, breeding environment public health have attracted attention, it is particularly environment
Venereal disease opportunistic pathogen has become the normal in bacterium and the hidden danger of frequently-occurring disease of farm.Expert thinks, influence of the aerosol to breeding environment
Very big, the aerosol that the pathogen being especially suspended in air is formed can cause large-scale bacteriosis.Some cause of diseases
Bacterium, virus can also be propagated by the exchange of water body, trigger the generation of the extensive disease of aquaculture.Intensive culture process lacks
Point is the breeding for easily causing invasive organism, and the factor such as stocking density height, the narrow, environmental stress of range of movement causes to move
Object matter is poor, may cause bacterial infection disease.Correspondingly, bird flu, SARS, food security etc. jeopardize people's existence
The sensitive event of space, living environment etc. worldwide occurs often.So the bacillary and viral disease of prevention for
It is particularly important that for aquaculture just, if disinfection work can be carried out timely and effectively, it is possible to reduce environment pathogenic microorganism, into
And reduce the incidence of animal bacteria disease.For sterilizing reagent, although the product category commercially to circulate is various, greatly
It is most there is have the shortcomings that pollution, easily residual, irritation is strong or bactericidal effect is poor.It follows that carry out new, efficient, logical
There is important scientific meaning and application value with the strong disinfectant of property.
Halogen disinfectant is common disinfectant in aquaculture, and halogen refers to periodic table of elements Section VII major element, it
All there are seven electronics (ns of outermost layer2np5) unsaturated structure, so being readily available one electronically forms rock-steady structure.
Common halogen disinfectant includes three kinds, they are chlorine-containing disinfectant, iodine class disinfectant and bromine-containing disinfectant respectively.Wherein, 1)
All in occupation of the critical positions of aquaculture disinfectant since chlorine-containing disinfectant-straight, mainly there are sodium hypochlorite, bleaching powder, trichlorine
Isocyanuric acid, sodium dichloroisocyanurate etc..These disinfectants are all that its mechanism of action is to pass through for main disinfection composition with " chlorine "
Hypochlorous acid is formed in water to sterilize or reach sterilization purpose by the enzyme system of oxidation destruction microorganism.But,
The effect that this kind of disinfectant kills microorganism is substantially influenced by water environmental factor, is strengthened usually as temperature raises, and
And weaken as water pH value raises；In addition, chlorine-containing disinfectant is larger to the irritation of aquatic livestock, when organic matter in water body
The positive effect sterilized when excessive declines.2) very widely used today iodine class disinfectant mainly include double-strand quaternary amine chelated iodine and
Povidone iodine, its sterilization and disinfection mechanism gradually decomposite free-iodine when being and using, halogenation are carried out between microprotein,
Make it dead.Wherein, double-chain quaternary ammonium salt chelated iodine is comparatively ideal chlorine-containing disinfectant substitute products.This is because double-chain quaternary ammonium salt
Chelated iodine plays the synergistic effect of double-chain quaternary ammonium salt and iodine, kills virus and the scope of bacterium is wider, and disinfection force is from water
The influence of matter hardness and acid-base value.Meanwhile iodine class disinfectant is small to the irritation of aquatic livestock, security is higher, but iodine is easy
Volatilization, stability are poor.3) the common bromine-containing disinfectant of in the market is primarily referred to as bromochloroin, C5H6Br2N2O2, its mechanism of action
It is to form hypobromous acid in water, the biology enzyme oxygenolysis in microbial body is failed.The characteristics of this kind of disinfectant is can
Consumption of the organic matter to halogen is effectively prevented, in use, can obtain preferable Disinfection Effect in different fertilizer degree water bodys, and
Also there is good slow release, bactericidal nature can be maintained for a long time.There is good bactericidal effect in the range of pH value 5-9.Cause
This, bromine-containing disinfectant overcomes the shortcomings that conventional chlorinated product bactericidal effect is influenced by water environmental factor.
From the foregoing, it will be observed that compared with active ingredient-chlorine (Cl) in chlorine-containing disinfectant, advantage of the bromine in sterilization is mainly wrapped
Include：1) in alkaline water body and body containing ammonium hydroxide, bromine has higher bactericidal activity than chlorine；Chlorine and bromine are with the ammonia in water and other containing
Nitrogen compound reacts rapidly the corresponding chlorine ammonia of generation and bromine ammonia.Given birth to when a chlorine ammonia is mainly generated when being handled with chlorine, and being handled with bromine
Into the mixture of monobromo ammonia, dibromo ammonia and tribromo ammonia.Chlorine ammonia is highly stable in water, and bromine ammonia fast decoupled.The sterilization of bromine ammonia
Activity is than chlorine ammonia bactericidal activity higher；Summary is understood, in the water system under the conditions of body containing ammonium hydroxide and most of high pH, bromine
Performance exceed chlorine, bromine is faster than the sterilization speed of chlorine, therefore, bromine-containing disinfectant have higher disinfection.2) volatilization of bromine
Property is less than chlorine so that bromine is less susceptible to cause damages because of volatilization than chlorine；According to air-water distribution coefficient (Henry law constants),
The volatility for understanding chlorine is about 10 times of bromine, and hypohalogenous acids is more much smaller than corresponding gaseous halogen volatility.Hypochlorous volatilization
Property is 2 times of hypobromous acid；Here, although in alkaline pH and substantially non-volatile without the hypochlorite in ammonium hydroxide, exist in ammonia
Lower chlorine exists in the form of chlorine ammonia, and volatility is more than hypochlorous acid.It is as follows according to Henry law constants (20 DEG C) volatile order：
Ozone>Chlorine dioxide>Chlorine ammonia>Hypochlorous acid>Hypobromous acid.So the stability of bromine-containing disinfectant is higher than chlorine system under general condition
Agent.3) corrosivity is small when bromine is handled；Chlorine has the oxidisability of higher than bromine, therefore using the same dose of bromines to gold
The corrosivity of category is less than chlorine.It is well known that chlorine forms hypochlorous acid in low pH cooling water systems causes metal erosion.It is many to grind
Study carefully and show, corrosion rate of the disinfectant to carbon steel, stainless steel and copper alloy can be reduced for chlorine using bromo.Containing ammonia or alkalescence
In water, bromine corrosivity is less than chlorine, is because the dosage of bromine is low when reaching the chlorine residue of demand.And in acid condition
Under, bromide is similar to chlorion to the Electrochemical Performances of iron.But during with bromide, when spot corrosion ratio villaumite of stainless steel, is small
Much.4) free bromine and bromine compounds decay rate are fast, and pollution on the environment is small；Because residual chlorine oxidant is toxic,
All the pollution caused by discharge of wastewater is attached great importance to countries in the world.The toxicity of halogen mainly due to its reactivity and
Caused by the reaction product quickly formed.In some cases, haloform, three halogen will be formed especially in the presence of humic acid
Methane is proved to be a kind of carcinogen, therefore various countries' drinking-water has it stringent regulation.Reacting to form chloroform with chlorine
Under conditions of, bromine also generates bromofom to a certain extent, but the two maximum difference is bromofom fast decoupled in the environment, therefore
Its toxicity is far smaller than chloroform.According to surveying and determination, the half-life period of bromofom is 15 days, and chloroform is 50 days, is especially existed in microorganism
The decomposition rate of lower bromofom faster, in the dilution water containing identical chlorine and bromine, activity to fish test shows that, through putting 96 in a suitable place to breed
It is all dead in chloride water fish after hour, and in brominated water fish well-grown.It is similar to chlorination reaction, in water body
Organic compound occur bromination in bromination reaction, experiment shows that chlorinated organics are toxic to animal and fishing gear, and occurs
Biological accumulation.When being handled with bromine, water also produces bromination organic matter.But because its content is relatively fewer, it is difficult to discriminate between out.Base
It is water conservation, there is stringent Con trolling index in environmental protection administration to discharging small chlorine residue, overproof to discharge in above reason
Before must carry out dechlorination processing, and bromine is then required without this.
Iodophor class disinfectant have wide spectrum bactericidal effect, can kill bacterium, gemma, virus, bacteriophage, mycobacterium,
The pathogen such as protozoon, fungi.Iodophor (iodophor) is the complex compound of the indefinite form of formation such as iodine and surfactant (carrier),
It is substantially a kind of surfactant containing iodine.It is not to be connected with chemical bond between Iodophor various composition, is iodine and carrier
The uncertain complex compound of molecular size formed in the form of complexing or inclusion by hydrogen bond and other graviational interactions.At present, though
The exploitation and production of right Iodophor class product are ripe, but have the bromine for being similarly composed structure and sterilizing function with iodine, but always
Fail to emerge with the product form of " bromine volt " or compound " bromine Iodophor ", its technological difficulties developed is bromine sheet as liquid
Body, and it is readily volatilized, there are extremely strong strong toxic and corrosivity, it is relatively hazardous in practical operation.
The content of the invention
It is an object of the invention to overcome the deficiencies in the prior art, and adding stabilizer makes bromine (and iodine) be complexed with it
So as to suppressing its volatilization, reduce the danger of production and lost caused by bromine volatilizees, so again with special properties it is non-from
Sub- surfactant polyoxyethylene ether is in connection, plays Quadratic Stability and diluting effect, is then mixed with synergist solution
It is even to form disinfection liquid product
Being fixed the invention solves bromine prevents its volatilization, how with iodine addition for composite, pass through to compound and formed
The problem of how stablizing its quality after stable uniform liquid medicine.High concentration provided by the invention consolidates bromine disinfectant products " bromine volt "
And it is by coordination network using bromine and iodine as the preparation method of the composite sterilizer sterile products " bromine Iodophor " of active ingredient
Legal and Micellar Solubilization method, using bromine or iodine as disinfection source, by adding surfactant, stabilizer, synergist, through thing
Reason mixing forms it into stable disinfectant solution with being prepared under chemical coordination effect.
The present invention by following technical scheme in order to solve the above technical problems, be achieved：
Efficient sterilization disinfectant " bromine volt " is made of each component, and each constituent content is as follows：
It is preferably as follows：
Efficient sterilization disinfectant " bromine Iodophor " is made of each component, and each constituent content is as follows：：
It is preferably as follows：
In efficient sterilization disinfectant " bromine volt " and efficient sterilization disinfectant " bromine Iodophor ", bromine is simple substance bromine.
In efficient sterilization disinfectant " bromine Iodophor ", the mass ratio 1 of bromine and iodine:1-10:1.
In efficient sterilization disinfectant " bromine volt " and efficient sterilization disinfectant " bromine Iodophor ", the surfactant for it is non-from
Subtype surfactant, octylphenolpolyoxyethylene, such as OP-4, OP-7, OP-9, OP-10, OP-12, OP-15, or alkyl
Phenol and ethylene oxide condensate, such as TX-4, TX-7, TX-9, TX-10, TX-12, or nonylphenol polyoxyethylene ether, such as
NP-9, NP-10, NP-15, or fatty alcohol polyoxyethylene ether, such as AEO-3, AEO-5, AEO-7, AEO-9；Wherein, poly alkyl alcohol
The mass ratio of ethylene oxide ether and octylphenolpolyoxyethylene is 1：(0.3-1), nonylphenol polyoxyethylene ether and fatty alcohol polyoxy second
The mass ratio of alkene ether is 1：The mass ratio of (0.6-1.5), condensation compound of alkyl phenol and epoxy ethane and octylphenolpolyoxyethylene is
1：The mass ratio of (0.5-1), condensation compound of alkyl phenol and epoxy ethane and octylphenolpolyoxyethylene is 1：(0.5-1).
In efficient sterilization disinfectant " bromine volt " and efficient sterilization disinfectant " bromine Iodophor ", the stabilizer is ethanol, third
Alcohol, butanol, ethylene glycol, glycerine, sulfamic acid, monoethanolamine, diethanol amine or urea, optimum amount are 7-12 mass
Part.
In efficient sterilization disinfectant " bromine volt " and efficient sterilization disinfectant " bromine Iodophor ", the synergist for sodium chloride,
Potassium chloride or lithium chloride.
The preparation method of efficient sterilization disinfectant " bromine volt ", carries out as steps described below：
Step 1, according to the content requirement of each component, it is respectively cooperating with the first solution (ie in solution A) and the second solution is (instant
Liquid B)：Bromine is slowly added into stabilizer and is stirred to being completely dissolved, surfactant is added and stirs evenly to form first
Solution；Synergist is added under stirring condition in water to being completely dissolved, forms the second solution；
Step 2, the first solution and the second solution are uniformly mixed under agitation, forms it into brown liquid product, i.e.,
Efficient sterilization disinfectant " bromine volt ".
The preparation method of efficient sterilization disinfectant " bromine Iodophor ", carries out as steps described below：
Step 1, according to the content requirement of each component, it is respectively cooperating with the first solution (ie in solution A) and the second solution is (instant
Liquid B)：Bromine and iodine are slowly added into stabilizer and stirred to being completely dissolved, surfactant is added and stirs evenly
Form the first solution；Synergist is added under stirring condition in water to being completely dissolved, forms the second solution；
Step 2, the first solution and the second solution are uniformly mixed under agitation, forms it into brown liquid product, i.e.,
Efficient sterilization disinfectant " bromine Iodophor ".
Compared with prior art, efficient sterilization disinfectant of the invention " bromine volt ", " bromine Iodophor " have following features：
(1) disinfection liquid product has the characteristics that wide spectrum, efficient, safe and excitatory small, to the accommodation of water pH value
Extensively, there is strong sterilization, kill the virus, can effectively kill most bacterial propagule, gemma, virus, fungi, original
The pathogenic microorganisms such as worm, bacteriophage.
(2) overcome free-iodine be insoluble in water, unstable, irritation be big, coloring not fugitive color the shortcomings of, and price is low
It is honest and clean, it is economical and practical, it is suitable for disinfection and fish, the prevention of shrimp, poultry, avian disease of the aquaculture as cultivated factory.
(3) disinfection that liquid product can be used for culture fishery is sterilized, from water body environment condition under the conditions of conventional cultivation
Limitation, be applicable in various types of breeding water body, meanwhile, also have effects that improvement water quality.
(4) bactericidal activity in alkaline water body and body containing ammonium hydroxide is very high, its effect is much better than chlorine-containing disinfectant.
(5) it is relatively slow to sterilize corrosion of the liquid product to metal products such as mild steel, stainless steel and copper alloys, and dissociates
Bromine and bromine compounds decay rate are fast, and pollution on the environment is smaller.
(6) operate during use easily, splash after only need to being directly diluted with water.
(7) addition of stabilizer and surfactant, can reduce bromine volatile zone come danger and loss, while
Adding synergist in long-term placement can also prevent bromine iodine from changing into high-valence state compounds affect product quality.
(8) active ingredient is not compound that chemical bond is connected together in this thimerosal, it be it is intermolecular have it is certain
The part of affinity attract each other draw close or with electrostatic attraction formed compound.Bromine and iodine by be complexed or inclusion in the form of
It is present among carrier, bromine and elemental iodine can be discharged after being diluted with water, and then react generation hypobromous acid and hypoiodous acid, strengthens it
Sterilize the performance of antivirus；Here, since bromine and iodine are in the state being complexed by carrier or by ring inclusion, so product is stablized
Performance is good.
(9) in addition to washability, it also has somatic cells stronger nonionic surfactant (polyoxyethylene ether)
Affinity interaction, it is outer as carrier and cosolvent and bromine and iodine complexing, the affinity of somatic cells is strengthened, can be by contained bromine
It is transported to iodine on somatic cells film, and the target tissue majority of bromine and iodine, on cytoplasm or cell membrane, one is combined, that is, penetrates
Cell membrane, is sterilized up to mycoprotein deep.For this reason, polyoxyethylene ether plays synergic remove with bromine or iodine complexing,
Effectively increase Disinfection Effect.
(10) " bromine volt " is that high concentration consolidates bromine disinfectant products, only using bromine source as the fungicide of control of microorganisms, and " bromine
The composite sterilizer sterile products that Iodophor " is bromine and iodine is active ingredient, bromine can act synergistically in use with iodine
Carry out control of microorganisms.
Reasonable, the safe technological process of production that the present invention additionally uses, reaction kettle need to possess sealing, stirring condition, material
Enamel still need to be used, avoids corrosion of the bromine to metal kettle, preparation process must be stirred continuously lower progress, and ensure each component
It is completely dissolved.Product property is stablized, and effective time greatly prolongs.Therefore, it can be said that this product is a kind of preferably efficient, wide
Spectrum, storage is stablized, toxicity is low and possesses the disinfectant of cleaning and decontamination.
Specific embodiment
Technical scheme is further illustrated with reference to specific embodiment.
Embodiment 1
It is 18 DEG C in environment temperature, under conditions of relative humidity is 30%, takes bromine 15Kg；Surfactant is AEO-9
30Kg、OP-9 10Kg；Stabilizer is ethanol 10Kg；Synergist is sodium chloride 5Kg；Water 30Kg.
1) first 15Kg bromines are slowly added into 10Kg ethanol, be stirred continuously to being completely dissolved, then by this mixed solution
Add into the mixed liquor of 10Kg OP-9 and 30KgAEO-9, being stirred continuously makes it be mixed into homogeneous solution A；
2) 5Kg sodium chloride to being completely dissolved, makes into solution B in 30Kg water under stirring；
3) above-mentioned solution A and solution B are mixed, is stirred continuously, makes into brown-red solution, that is, be configured to the volt production of 100Kg bromines
Product.
Embodiment 2
It is 20 DEG C in environment temperature, under conditions of relative humidity is 35%, takes bromine 7.5k Kg；Surfactant is NP-
10 15Kg、OP-7 15Kg；Stabilizer is sulfamic acid 5Kg；Synergist is potassium chloride 10Kg；Water 47.5Kg.
1) first by 7.5Kg bromines be slowly added to dissolved with the 10Kg water of 5Kg sulfamic acids, be stirred continuously to completely it is molten
Solution, then this mixed solution is added into the mixed liquor of 15Kg NP-10 and 15Kg OP-7, be stirred continuously make into be uniformly mixed it is molten
Liquid A；
2) 10Kg potassium chloride is added to being completely dissolved in 37.5Kg water under stirring, and makes into solution B；
3) above-mentioned solution A and solution B are mixed, is stirred continuously, makes into brown-red solution, that is, be configured to the volt production of 100Kg bromines
Product.
Embodiment 3
It is 29 DEG C in environment temperature, under conditions of relative humidity is 45%, takes bromine 10Kg；Surfactant is OP-10
20Kg；Stabilizer is glycerine 15Kg；Synergist is lithium chloride 13Kg, sodium chloride 2Kg；Water 40Kg.
1) first 10Kg bromines are slowly added into 15Kg glycerine, be stirred continuously to being completely dissolved, then this mixing is molten
Liquid is added into the mixed liquor of 20Kg OP-10, and being stirred continuously makes into mixed solution A；
2) 13Kg lithium chlorides, 2Kg sodium chloride are added to being completely dissolved in 40Kg water under stirring, makes into solution B；
3) above-mentioned solution A and solution B are mixed, is stirred continuously, makes into brown-red solution, that is, be configured to the volt production of 100Kg bromines
Product.
Embodiment 4
It is 25 DEG C in environment temperature, under conditions of relative humidity is 30%, takes bromine 10Kg；Surfactant is AEO-9
15Kg、OP-9 15Kg；Stabilizer is ethanol 10Kg；Synergist is lithium chloride 13Kg；Water 37Kg.
1) first 10Kg bromines are slowly added into 10kg ethanol, be stirred continuously to being completely dissolved, then by this mixed solution
Add into the mixed liquor of 15Kg OP-9 and 15KgAEO-9, being stirred continuously makes into mixed solution A；
2) 13Kg lithium chlorides are added to being completely dissolved in 37Kg water under stirring, make into solution B；
3) above-mentioned solution A and solution B are mixed, is stirred continuously, makes into brown-red solution, that is, be configured to the volt production of 100Kg bromines
Product.
Embodiment 5
It is 25 DEG C in environment temperature, under conditions of relative humidity is 35%, takes bromine 11Kg；Surfactant is TX-10
12.5Kg、OP-10 12.5Kg；Stabilizer is monoethanolamine 8Kg；Synergist is sodium chloride 12Kg；Water 44Kg.1) first by 11Kg
Bromine is slowly added in 8Kg monoethanolamines, is stirred continuously to being completely dissolved, then this mixed solution is added to 12.5Kg TX-10
In the mixed liquor of 12.5Kg OP-10, being stirred continuously makes into mixed solution A；
2) 12Kg sodium chloride is added to being completely dissolved in 44Kg water under stirring, and makes into solution B；
3) above-mentioned solution A and solution B are mixed, is stirred continuously, makes into brown-red solution, that is, be configured to the volt production of 100Kg bromines
Product.
Embodiment 6
It is 22 DEG C in environment temperature, under conditions of relative humidity is 35%, takes bromine 5.7Kg, iodine 1Kg；Live on surface
Property agent is OP-4 10Kg, OP-15 10Kg；Stabilizer is propyl alcohol 8.5Kg；Synergist is potassium chloride 5Kg；Water 59.8Kg.
1) first 5.7Kg bromines and 1.0Kg iodines are slowly added into 8.5Kg propyl alcohol, be stirred continuously to be uniformly mixed,
This mixed solution is added into the mixed liquor of 10Kg OP-4 and 10KgOP-15 again, being stirred continuously makes it be mixed into homogeneous solution
A；
2) 5Kg potassium chloride is added to being completely dissolved in 59.8Kg water under stirring, and makes into solution B；
3) above-mentioned solution A and solution B are mixed, is stirred continuously, becomes dark red brown-red solution, that is, be configured to
100Kg bromine Iodophor products.
Embodiment 7
It is 25 DEG C in environment temperature, under conditions of relative humidity is 40%, takes bromine 5.7Kg, iodine 1Kg；Live on surface
Property agent is OP-10 15Kg, AEO-7 10Kg；Stabilizer is ethanol 8.5Kg；Synergist is sodium chloride 4.8Kg；Water 55Kg.
1) first 5.7Kg bromines and 1.0Kg iodines are slowly added into 8.5Kg ethanol, be stirred continuously to be uniformly mixed,
This mixed solution is added into the mixed liquor of 15Kg OP-10 and 10KgAEO-7 again, be stirred continuously make its be mixed into uniformly it is molten
Liquid A；
2) 4.8Kg sodium chloride is added to being completely dissolved in 55Kg water under stirring, and becomes solution B；
3) above-mentioned solution A and solution B are mixed, is stirred continuously, becomes dark red brown-red solution, that is, be configured to
100Kg bromine Iodophor products.
Embodiment 8
It is 19 DEG C in environment temperature, under conditions of relative humidity is 30%, takes bromine 8.5Kg, iodine 1Kg；Live on surface
Property agent is NP-10 10Kg, AEO-3 15Kg；Stabilizer is diethanol amine 13.5Kg；Synergist is potassium chloride 7Kg；Water 45Kg.
1) first 8.5Kg bromines and 1.0Kg iodines are slowly added into 13.5Kg diethanol amine, are stirred continuously to mixing
Uniformly, then by this mixed solution add into the mixed liquor of 10Kg NP-10 and 15KgAEO-3, being stirred continuously makes it be mixed into
Even solution A；
2) 7Kg potassium chloride is added to being completely dissolved in 45Kg water under stirring, and becomes solution B；
3) above-mentioned solution A and solution B are mixed, is stirred continuously, becomes dark red brown-red solution, that is, be configured to
100Kg bromine Iodophor products.
Embodiment 9
It is 20 DEG C in environment temperature, under conditions of relative humidity is 45%, takes bromine 4.5Kg, iodine 1.5Kg；Surface
Activating agent is NP-4 15Kg, AEO-7 10Kg；Stabilizer is glycerine 13.5Kg；Synergist is sodium chloride 1.5Kg, potassium chloride
5.5Kg；Water 48.5Kg.
1) first 4.5Kg bromines and 1.5Kg iodines are slowly added into 13.5Kg glycerine, are stirred continuously equal to mixing
It is even, then this mixed solution is added into the mixed liquor of 15Kg NP-4 and 10KgAEO-7, being stirred continuously makes it be mixed into uniformly
Solution A；
2) 1.5Kg sodium chloride and 5.5Kg potassium chloride are added to being completely dissolved in 48.5Kg water under stirring, is become molten
Liquid B；
3) above-mentioned solution A and solution B are mixed, is stirred continuously, becomes dark red brown-red solution, that is, be configured to
100Kg bromine Iodophor products.
Embodiment 10
It is 18 DEG C in environment temperature, under conditions of relative humidity is 35%, takes bromine 6.5Kg, iodine 1.5Kg；Surface
Activating agent is TX-10 10Kg, OP-7 10Kg；Stabilizer is ethanol 13.5Kg；Synergist is sodium chloride 7.5Kg；Water 51Kg.
1) first 6.5Kg bromines and 1.5Kg iodines are slowly added into 13.5Kg ethanol, are stirred continuously equal to mixing
It is even, then this mixed solution is added into the mixed liquor of 10Kg TX-10 and 10KgOP-7, being stirred continuously makes it be mixed into uniformly
Solution A；
2) 7.5Kg sodium chloride is added to being completely dissolved in 51Kg water under stirring, and becomes solution B；
3) above-mentioned solution A and solution B are mixed, is stirred continuously, becomes dark red brown-red solution, that is, be configured to
100Kg bromine Iodophor products.
Using Escherichia coli 1.2385；Aeromonas hydrophila 2016-TM-04；Staphylococcus aureus WB003；Thermophilic aqueous vapor
For monad HA-336 as test strain, the bromine volt and bromine Iodophor prepared using embodiment is dilute using two times as test drug
Interpretation of the law is tested, bacterium dense 103-104cfu/mL.Medicine is with after bacterium effect 30min, being down flat plate, 24h, after 30 DEG C of cultures, records
Bacterium growing state, it is as shown in the table.From the point of view of the average result of test, bromine volt and bromine Iodophor have stronger bactericidal effect,
Also there is good bactericidal effect at low concentrations.
The adjustment that the formula and method recorded according to present invention part carry out each constituent content can prepare this hair
Bright disinfectant, shows for the basically identical property of the embodiment of the present invention after tested.Example has been done to the present invention above
Property description, it should explanation, in the case where not departing from the core of the present invention, any simple deformation, modification or its
His those skilled in the art can not spend the equivalent substitution of creative work to each fall within protection scope of the present invention.
Claims (9)
1. efficient sterilization disinfectant, it is characterised in that by ligand complex method and Micellar Solubilization method, using bromine or iodine to disappear
Malicious source, by adding surfactant, stabilizer, synergist, prepares through physical mixed and chemical coordination effect are lower, forms it into
Stable disinfectant solution " bromine volt " and " bromine Iodophor ", wherein
Efficient sterilization disinfectant " bromine volt " is made of each component, and each constituent content is as follows：
Efficient sterilization disinfectant " bromine Iodophor " is made of each component, and each constituent content is as follows：：
2. efficient sterilization disinfectant according to claim 1, it is characterised in that in efficient sterilization disinfectant " bromine volt ",
Each constituent content is preferably as follows：
In efficient sterilization disinfectant " bromine Iodophor ", each constituent content is preferably as follows：
3. the efficient sterilization disinfectant according to claims 1 or 2, it is characterised in that bromine is simple substance bromine.
4. the efficient sterilization disinfectant according to claims 1 or 2, it is characterised in that the mass ratio of bromine and iodine
Example 1:1-10:1.
5. the efficient sterilization disinfectant according to claims 1 or 2, it is characterised in that the surfactant for it is non-from
Subtype surfactant, octylphenolpolyoxyethylene, such as OP-4, OP-7, OP-9, OP-10, OP-12, OP-15, or alkyl
Phenol and ethylene oxide condensate, such as TX-4, TX-7, TX-9, TX-10, TX-12, or nonylphenol polyoxyethylene ether, such as
NP-9, NP-10, NP-15, or fatty alcohol polyoxyethylene ether, such as AEO-3, AEO-5, AEO-7, AEO-9；Wherein, poly alkyl alcohol
The mass ratio of ethylene oxide ether and octylphenolpolyoxyethylene is 1：(0.3-1), nonylphenol polyoxyethylene ether and fatty alcohol polyoxy second
The mass ratio of alkene ether is 1：The mass ratio of (0.6-1.5), condensation compound of alkyl phenol and epoxy ethane and octylphenolpolyoxyethylene is
1：The mass ratio of (0.5-1), condensation compound of alkyl phenol and epoxy ethane and octylphenolpolyoxyethylene is 1：(0.5-1).
6. the efficient sterilization disinfectant according to claims 1 or 2, it is characterised in that the stabilizer is ethanol, third
Alcohol, butanol, ethylene glycol, glycerine, sulfamic acid, monoethanolamine, diethanol amine or urea.
7. the efficient sterilization disinfectant according to claims 1 or 2, it is characterised in that the synergist is sodium chloride, chlorine
Change potassium or lithium chloride.
8. the preparation method of efficient sterilization disinfectant " bromine volt ", it is characterised in that carry out as steps described below：
Step 1, according to the content requirement of each component, the first solution (ie in solution A) and the second solution (ie in solution are respectively cooperating with
B)：Bromine is slowly added into stabilizer and is stirred to being completely dissolved, surfactant is added and stirs evenly that to form first molten
Liquid；Synergist is added under stirring condition in water to being completely dissolved, forms the second solution；
Step 2, the first solution and the second solution are uniformly mixed under agitation, forms it into brown liquid product, i.e., efficiently
Disinfection sanitizer " bromine volt ".
9. the preparation method of efficient sterilization disinfectant " bromine Iodophor ", it is characterised in that carry out as steps described below：
Step 1, according to the content requirement of each component, the first solution (ie in solution A) and the second solution (ie in solution are respectively cooperating with
B)：Bromine and iodine are slowly added into stabilizer and stirred to being completely dissolved, surfactant is added and stirs evenly shape
Into the first solution；Synergist is added under stirring condition in water to being completely dissolved, forms the second solution；
Step 2, the first solution and the second solution are uniformly mixed under agitation, forms it into brown liquid product, i.e., efficiently
Disinfection sanitizer " bromine Iodophor ".
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111109257A (en) * | 2019-12-30 | 2020-05-08 | 河北华邦生物科技有限公司 | Ultrahigh-distribution-coefficient composite iodine solution and preparation method thereof |
| WO2021093271A1 (en) * | 2019-11-12 | 2021-05-20 | 南京华洲药业有限公司 | Beta cypermethrin nano aqueous agent, preparation method therefor and use thereof |
Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1275401A (en) * | 1968-02-16 | 1972-05-24 | Dipenidam Ltd | Improvements in and relating to disinfectant compositions |
| CN1114527A (en) * | 1995-02-17 | 1996-01-10 | 四川省卫生防疫科技开发服务中心 | Complex iodine liquid disinfectant |
| CN1337919A (en) * | 1999-04-21 | 2002-02-27 | 纳尔科化学公司 | Stable oxidizing bromine formulations, method of manufacture and uses thereof for biofouling control |
| CN1345385A (en) * | 1999-03-31 | 2002-04-17 | 纳尔科化学公司 | Stabilized bromine solutions, method of manufacture and uses thereof for biofouling control |
| CN1480044A (en) * | 2003-07-04 | 2004-03-10 | 同联集团沈阳抗生素厂 | High performance iodine disinfection liquid |
| EP1266571B1 (en) * | 2001-06-15 | 2006-11-29 | Oftrai, S.L. | Desinfecting and antiseptic composition |
| CN101766162A (en) * | 2009-01-07 | 2010-07-07 | 曹新国 | Aerosol air disinfectant |
| CN101999403A (en) * | 2009-09-02 | 2011-04-06 | 中国石油天然气股份有限公司 | Preparation method of liquid stable bromine biocide |
| CN102363616A (en) * | 2011-10-18 | 2012-02-29 | 山东美罗福农化有限公司 | Probenazole low-toxicity bactericide and preparation method thereof |
| CN102771513A (en) * | 2012-07-21 | 2012-11-14 | 辽宁力普工业技术有限公司 | Preparation method of liquid stable bromine bactericide using elemental bromine as bromine source |
| CN104068055A (en) * | 2014-06-27 | 2014-10-01 | 江苏丽莎环保科技有限公司 | Inorganic bromine disinfectant as well as preparation method and application thereof |
| CN105557751A (en) * | 2015-05-18 | 2016-05-11 | 深圳市安多福动物药业有限公司 | Macromolecular bioorganic iodine, method for preparing same and method for preventing and treating aquaculture diseases |
-
2016
- 2016-11-02 CN CN201610943110.0A patent/CN108013072B/en active Active
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1275401A (en) * | 1968-02-16 | 1972-05-24 | Dipenidam Ltd | Improvements in and relating to disinfectant compositions |
| CN1114527A (en) * | 1995-02-17 | 1996-01-10 | 四川省卫生防疫科技开发服务中心 | Complex iodine liquid disinfectant |
| CN1345385A (en) * | 1999-03-31 | 2002-04-17 | 纳尔科化学公司 | Stabilized bromine solutions, method of manufacture and uses thereof for biofouling control |
| CN1337919A (en) * | 1999-04-21 | 2002-02-27 | 纳尔科化学公司 | Stable oxidizing bromine formulations, method of manufacture and uses thereof for biofouling control |
| EP1266571B1 (en) * | 2001-06-15 | 2006-11-29 | Oftrai, S.L. | Desinfecting and antiseptic composition |
| CN1480044A (en) * | 2003-07-04 | 2004-03-10 | 同联集团沈阳抗生素厂 | High performance iodine disinfection liquid |
| CN101766162A (en) * | 2009-01-07 | 2010-07-07 | 曹新国 | Aerosol air disinfectant |
| CN101999403A (en) * | 2009-09-02 | 2011-04-06 | 中国石油天然气股份有限公司 | Preparation method of liquid stable bromine biocide |
| CN102363616A (en) * | 2011-10-18 | 2012-02-29 | 山东美罗福农化有限公司 | Probenazole low-toxicity bactericide and preparation method thereof |
| CN102771513A (en) * | 2012-07-21 | 2012-11-14 | 辽宁力普工业技术有限公司 | Preparation method of liquid stable bromine bactericide using elemental bromine as bromine source |
| CN104068055A (en) * | 2014-06-27 | 2014-10-01 | 江苏丽莎环保科技有限公司 | Inorganic bromine disinfectant as well as preparation method and application thereof |
| CN105557751A (en) * | 2015-05-18 | 2016-05-11 | 深圳市安多福动物药业有限公司 | Macromolecular bioorganic iodine, method for preparing same and method for preventing and treating aquaculture diseases |
Non-Patent Citations (3)
| Title |
|---|
| 孙世刚: "《物理化学.下》", 31 December 2008, 厦门大学出版社 * |
| 李孟 等: "《新型水处理材料的理论与应用研究》", 31 August 2005, 武汉理工大学出版社 * |
| 熊道陵 等: "《洗油分离精制应用技术》", 31 October 2013, 冶金工业出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021093271A1 (en) * | 2019-11-12 | 2021-05-20 | 南京华洲药业有限公司 | Beta cypermethrin nano aqueous agent, preparation method therefor and use thereof |
| CN111109257A (en) * | 2019-12-30 | 2020-05-08 | 河北华邦生物科技有限公司 | Ultrahigh-distribution-coefficient composite iodine solution and preparation method thereof |
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