CN107079908A - A kind of aquatic products thimerosal and preparation method thereof - Google Patents
A kind of aquatic products thimerosal and preparation method thereof Download PDFInfo
- Publication number
- CN107079908A CN107079908A CN201710408032.9A CN201710408032A CN107079908A CN 107079908 A CN107079908 A CN 107079908A CN 201710408032 A CN201710408032 A CN 201710408032A CN 107079908 A CN107079908 A CN 107079908A
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- thimerosal
- aquatic products
- parts
- preparation
- glutaraldehyde
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aliphatically bound aldehyde or keto groups, or thio analogues thereof; Derivatives thereof, e.g. acetals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
Abstract
The invention belongs to pharmaceutic preparation for livestock field, more particularly to a kind of aquatic products thimerosal and preparation method thereof；Aquatic products of the present invention is glutaraldehyde and benzalkonium bromide with thimerosal main active, and glutaraldehyde is aldehydes disinfectant, can kill bacterial propagule and gemma, fungi, virus；Benzalkonium bromide is double long chain cation surfactants, and its quaternary ammonium cation can actively attract negatively charged bacterium and virus and cover its surface, hinder bacterial metabolism, cause the permeability changes of film, and what is used with glutaraldehyde, with synergistic effect；Glutaraldehyde, benzalkonium bromide are evenly distributed in natural plant gum, are more stablized, are not susceptible to low temperature crystallization；Gel is prepared the excellent nano particle of dispersiveness, increase drug releasing surface product by high pressure homogenizer；Chitosan, sodium alginate are included in outside nano particle, and it controls the effect of sustained release so that antivirus effect extension；The preparation method of the aquatic products thimerosal of the present invention, it is simple to operate, it is adaptable to industrial production.
Description
Technical field
The invention belongs to pharmaceutic preparation for livestock field, more particularly to a kind of aquatic products thimerosal and preparation method thereof.
Background technology
Common disinfectant mainly has several major classes, halogen such as halogen, phenolic aldehyde alcohols, acid-base class, salt, quaternary ammonium salt
Disinfectant includes chloride class disinfectant, brominated class disinfectant and the disinfectant of class containing iodine etc., common are chlorine dioxide, bleaching powder,
Strong chlorine oil, BCDMH, PVP-I, compound iodine etc., mainly by acting on bacterial membrane surface, cytoplasm or the internal enzyme of destruction
Activity, makes bacterial death, reaches sterilisation purpose；Phenol, aldehyde, alcohol disinfectant are such as combined phenol, isopropanol, glutaraldehyde, main logical
Crossing makes bacterioprotein denaturation reach sterilizing purpose；In acid, alkali, salt, acids：Citric acid, acetic acid, formic acid, peroxide second
Acid etc. can make mycoprotein denaturation, precipitation or dissolve, and have killing effect, bases to various bacteria, fungi etc.：Conventional is aerobic
Change calcium, Ammonia, calcium oxide mixes generation calcium hydroxide with water, and discharges big calorimetric, can quick dissolution of bacteria albumen
Plasma membrane, makes its devitalization, so that the harmful organisms for killing pathogen in pond and residuing in pond, due to cheap, greatly
Measure for cleaning up the pond and prevention from suffering from the diseases, salt includes the conventional salt such as ferrous sulfate, niter cake, potassium permanganate, copper sulphate etc. is weighed
Hydrophobic grouping in metallic salt and quaternary ammonium salt etc., quaternary ammonium salt molecular structure can penetrate into bacterial cytoplasm film and protein layer,
Bacterium permeability is set to change, cellular content leaks and dead；Peroxide such as Peracetic acid, hydrogen peroxide, peroxide
Change calcium, ozone etc., with powerful oxidability, the activity in nascent oxygen, oxidizing bacteria body is released when being met with organic matter
Group.This kind of disinfectant sterilizing ability is strong, soluble in water, is decomposed in water and produces oxygen, can act also as oxygenation agent.
Culture environment of aquatic products is complex, and single disinfectant is not enough to reach excellent Disinfection Effect, in the prior art,
The disinfectant that above-mentioned a few class disinfectants progress simple superposition are made into complex class solves this problem, for example, prick glutaraldehyde and benzene
Bromine ammonium is combined, and antivirus effect is notable, but quaternary ammonium salt such as benzalkonium bromide has certain crystallization to separate out in low temperature in itself, therefore, is made
Disinfectant existence and stability it is not high the problem of.
The content of the invention
The present invention solves the not high technical problem of complex class disinfectant stability present in prior art.
To solve the above problems, technical scheme is as follows：
A kind of aquatic products thimerosal, includes the raw material of following parts by weight：
Glutaraldehyde：25-50 parts；
Benzalkonium bromide：10-30 parts；
Natural plant gum：10-15 parts；
Chitosan quaternary ammonium salt：3-7 parts；
Sodium alginate：3-7 parts；
Water：50-120 parts.
Preferably, described aquatic products thimerosal, it also includes the raw material of following parts by weight：Vanillic aldehyde：1-3 parts.
Preferably, the natural plant gum in sesbania gum, guar gum, flax gum, fenugreek gum any one or more.
A kind of preparation method of aquatic products thimerosal, comprises the following steps：
A. the glutaraldehyde, benzalkonium bromide are added to the water, it is well mixed after add natural plant gum, stirring to being completely dissolved,
Add homogeneous 2-4 times in high pressure homogenizer；
B. the chitosan quaternary ammonium salt is dissolved in the water, the step A obtained solutions added under being stirred vigorously continue to stir
For a period of time；
C. the sodium alginate is dissolved in hot water, the step B obtained solutions added under being stirred vigorously, continues to stir one
The section time, the aquatic products thimerosal is made.
Glutaraldehyde is aldehydes disinfectant, can kill bacterial propagule and gemma, fungi, virus；Benzalkonium bromide is double long-chains
Cationic surfactant, its quaternary ammonium cation can actively attract negatively charged bacterium and virus and cover its surface, hinder
Bacterial metabolism, causes the permeability changes of film, and what is used with glutaraldehyde, with synergistic effect；Glutaraldehyde, benzalkonium bromide are uniformly distributed
In natural plant gum, more stablize, be not susceptible to low temperature crystallization；Gel is prepared the excellent nanometer of dispersiveness by high pressure homogenizer
Grain, increase drug releasing surface product；Chitosan, sodium alginate are included in outside nano particle, and it controls the effect of sustained release so that kill
Toxic effect power extends.
Preferably, high pressure homogenizer pressure described in step A is 200-300bar.
Preferably, in step A, the vanillic aldehyde is together added to the water with glutaraldehyde, benzalkonium bromide；Vanillic aldehyde improves and disappeared
The smell of venom.
Preferably, more than step B mixing speeds 8000rpm, more than mixing time 1min；High-speed stirred so that system is equal
It is even.
Preferably, more than step C mixing speeds 8000rpm, more than mixing time 1min；High-speed stirred so that system is equal
It is even.
Relative to prior art, advantages of the present invention is as follows,
The aquatic products thimerosal of the present invention, compares existing thimerosal, Disinfection Effect is more preferable, disinfection time is longer,
Thimerosal is highly stable simultaneously, is not influenceed substantially by system pH, salinity, temperature, will not occur low temperature crystallization phenomenon, various
Preferable Disinfection Effect is kept in environment；Available for breeding water body, cultivate utensil sterilization, prevent fish, shrimp, crab, soft-shelled turtle,
The bacteriosises such as bleeding, gill rot, ascites, enteritis, the Beancurd sheet of the aquatic livestocks such as the frog.
The preparation method of the aquatic products thimerosal of the present invention, it is simple to operate, it is adaptable to industrial production.
Embodiment
Embodiment 1：
A kind of aquatic products thimerosal, includes the raw material of following parts by weight：
Glutaraldehyde：25 parts；
Benzalkonium bromide：10 parts；
Sesbania gum：10 parts；
Chitosan quaternary ammonium salt：3 parts；
Sodium alginate：3 parts；
Water：50 parts.
Embodiment 2：
A kind of aquatic products thimerosal, includes the raw material of following parts by weight：
Glutaraldehyde：50 parts；
Benzalkonium bromide：30 parts；
Guar gum：15 parts；
Chitosan quaternary ammonium salt：7 parts；
Sodium alginate：7 parts；
Water：120 parts.
Embodiment 3：
A kind of aquatic products thimerosal, includes the raw material of following parts by weight：
Glutaraldehyde：35 parts；
Benzalkonium bromide：20 parts；
Vanillic aldehyde：2 parts；
Fenugreek gum：12 parts；
Chitosan quaternary ammonium salt：5 parts；
Sodium alginate：5 parts；
Water：100 parts.
Embodiment 4：
Aquatic products thimerosal is prepared using embodiment 1-3 raw material proportioning, preparation method comprises the following steps：
A. the glutaraldehyde, benzalkonium bromide are added to the water, it is well mixed after add natural plant gum, stirring to being completely dissolved,
Homogeneous 3 times in high pressure homogenizer are added, pressure is 250bar；
B. the chitosan quaternary ammonium salt is dissolved in the water, the step A obtained solutions added under being stirred vigorously, mixing speed
8000rpm, continues to stir 1min；
C. the sodium alginate is dissolved in hot water, the step B obtained solutions added under being stirred vigorously, mixing speed
8000rpm, continues to stir 1min；The aquatic products thimerosal is made.
Embodiment 5：
Stability test
Aquatic products thimerosal and comparative example group (penta sold on the market will be prepared using embodiment 1-3 raw material proportioning
Dialdehyde/benzalkonium bromide solution) be placed on 25 DEG C, 15 DEG C, 48 hours are stood under 4 DEG C of environment, as a result such as table one：
The stability of the thimerosal of table one at different temperatures
| Group | 25℃ | 15℃ | 4℃ |
| Embodiment 1 | Faint yellow supernatant liquid | Faint yellow supernatant liquid | Faint yellow supernatant liquid |
| Embodiment 2 | Faint yellow supernatant liquid | Faint yellow supernatant liquid | Faint yellow supernatant liquid |
| Embodiment 3 | Faint yellow supernatant liquid | Faint yellow supernatant liquid | Faint yellow supernatant liquid |
| Comparative example group | Faint yellow supernatant liquid | A small amount of crystallization is separated out | Mass crystallization is separated out |
Embodiment 6：
Disinfection Effect test
The water in rainbow trout culture experiment field is gathered, is dispensed in equal volume into 4 same containers, at the beginning of test staphylococcus aureus
Beginning concentration C 0, prepares aquatic products thimerosal by the raw material proportioning using embodiment 1-3 and comparative example group thimerosal (is gone out on the market
Glutaraldehyde/the benzalkonium bromide solution sold) it is configured in same concentrations 4 same containers of addition, respectively at survey after 2 days, 4 days, 8 days
The concentration C of ensaying staphylococcus aureus, calculates sterilizing rate=(C0-C)/C0, as a result such as table two：
Table two uses the survival rate of different thimerosal staphylococcus aureuses
It should be noted that above-described embodiment is only presently preferred embodiments of the present invention, not for limiting the present invention's
Protection domain, the equivalent substitution or replacement made on the basis of the above belongs to protection scope of the present invention.
Claims (8)
1. a kind of aquatic products thimerosal, it is characterised in that include the raw material of following parts by weight：
Glutaraldehyde：25-50 parts；
Benzalkonium bromide：10-30 parts；
Natural plant gum：10-15 parts；
Chitosan quaternary ammonium salt：3-7 parts；
Sodium alginate：3-7 parts；
Water：50-120 parts.
2. aquatic products thimerosal as claimed in claim 1, it is characterised in that also include the raw material of following parts by weight：
Vanillic aldehyde：1-3 parts.
3. aquatic products thimerosal as claimed in claim 1 or 2, it is characterised in that the natural plant gum is selected from sesbania gum, Guar
Any one or more in glue, flax gum, fenugreek gum.
4. the preparation method of aquatic products thimerosal as claimed in claim 1 or 2, it is characterised in that comprise the following steps：
A. the glutaraldehyde, benzalkonium bromide are added to the water, natural plant gum is added after being well mixed, stirring is added to being completely dissolved
Homogeneous 2-4 times in high pressure homogenizer；
B. the chitosan quaternary ammonium salt is dissolved in the water, the step A obtained solutions added under being stirred vigorously continue to stir one section
Time；
C. the sodium alginate is dissolved in hot water, the step B obtained solutions added under being stirred vigorously, when continuing to stir one section
Between, the aquatic products thimerosal is made.
5. the preparation method of aquatic products thimerosal as claimed in claim 3, it is characterised in that high pressure homogenizer described in step A
Pressure is 200-300bar.
6. the preparation method of aquatic products thimerosal as claimed in claim 3, it is characterised in that in step A, by the vanillic aldehyde
Together it is added to the water with glutaraldehyde, benzalkonium bromide.
7. the preparation method of aquatic products thimerosal as claimed in claim 3, it is characterised in that step B mixing speeds 8000rpm
More than, more than mixing time 1min.
8. the preparation method of aquatic products thimerosal as claimed in claim 3, it is characterised in that step C mixing speeds 8000rpm
More than, more than mixing time 1min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710408032.9A CN107079908A (en) | 2017-06-02 | 2017-06-02 | A kind of aquatic products thimerosal and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710408032.9A CN107079908A (en) | 2017-06-02 | 2017-06-02 | A kind of aquatic products thimerosal and preparation method thereof |
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| CN107079908A true CN107079908A (en) | 2017-08-22 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710408032.9A Pending CN107079908A (en) | 2017-06-02 | 2017-06-02 | A kind of aquatic products thimerosal and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113332310A (en) * | 2021-05-28 | 2021-09-03 | 中泓鑫海盐城生物技术有限公司 | Compound disinfectant for treating river crab shaking disease and preparation method and application thereof |
| CN115380857A (en) * | 2022-08-26 | 2022-11-25 | 海南上泰生物科技发展有限公司 | Prawn larva incubation method |
Citations (4)
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|---|---|---|---|---|
| CN102626403A (en) * | 2012-03-14 | 2012-08-08 | 北京万海康医科技有限公司 | Disinfectant for animals and its preparation method and use |
| CN102885041A (en) * | 2011-07-20 | 2013-01-23 | 洛阳惠中兽药有限公司 | Veterinary disinfectant and preparation method thereof |
| CN103503868A (en) * | 2012-06-23 | 2014-01-15 | 江苏胜意药业有限公司 | Preparation method for Yuxuekang |
| CN106614689A (en) * | 2016-12-10 | 2017-05-10 | 钦州学院 | Liquid disinfectant for aquaculture and preparation method thereof |
-
2017
- 2017-06-02 CN CN201710408032.9A patent/CN107079908A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102885041A (en) * | 2011-07-20 | 2013-01-23 | 洛阳惠中兽药有限公司 | Veterinary disinfectant and preparation method thereof |
| CN102626403A (en) * | 2012-03-14 | 2012-08-08 | 北京万海康医科技有限公司 | Disinfectant for animals and its preparation method and use |
| CN103503868A (en) * | 2012-06-23 | 2014-01-15 | 江苏胜意药业有限公司 | Preparation method for Yuxuekang |
| CN106614689A (en) * | 2016-12-10 | 2017-05-10 | 钦州学院 | Liquid disinfectant for aquaculture and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113332310A (en) * | 2021-05-28 | 2021-09-03 | 中泓鑫海盐城生物技术有限公司 | Compound disinfectant for treating river crab shaking disease and preparation method and application thereof |
| CN115380857A (en) * | 2022-08-26 | 2022-11-25 | 海南上泰生物科技发展有限公司 | Prawn larva incubation method |
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Application publication date: 20170822 |