CN113332310A - Compound disinfectant for treating river crab shaking disease and preparation method and application thereof - Google Patents
Compound disinfectant for treating river crab shaking disease and preparation method and application thereof Download PDFInfo
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- CN113332310A CN113332310A CN202110593982.XA CN202110593982A CN113332310A CN 113332310 A CN113332310 A CN 113332310A CN 202110593982 A CN202110593982 A CN 202110593982A CN 113332310 A CN113332310 A CN 113332310A
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- compound disinfectant
- river crab
- benzalkonium bromide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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Abstract
The invention discloses a compound disinfectant for treating river crab shaking diseases, a preparation method and an application thereof, wherein the compound disinfectant comprises the following components in percentage by weight: 60-68% of polyhexamethylene guanidine, 11-15% of benzalkonium bromide, 7-10% of didodecyldimethylammonium chloride and the balance of pure water. Compared with the prior art, the invention has the advantages that: the polyhexamethylene guanidine, the benzalkonium bromide and the didodecyldimethylammonium chloride which belong to the same cationic surfactant are compounded, and are ionized in a water solution to generate strong electropositivity, so that bacteria and viruses with negative charges can be adsorbed, and the sterilization and disinfection effects are better.
Description
Technical Field
The invention relates to a compound disinfectant, a preparation method and application thereof, in particular to a compound disinfectant for treating river crab shaking diseases, a preparation method and application thereof.
Background
River crab, also known as Eriocheir sinensis (Eriocheir sinensis), has tender meat, fresh taste and rich nutrition, is one of the main crustacean economic animals cultured in fresh water in China, and has more than 30 years of history of artificial culture. In recent years, with the continuous expansion of the culture scale, the types of river crab diseases are more and more, and the disease degree is more and more serious. The shaking disease of river crabs is particularly prominent. The symptoms of tremor are mainly manifested as tremor and curliness of the appendages, slow movements, and poor appetite. The disease is fast in onset, only 2-3 days from symptom to death, the death rate is high, the size of the survived river crabs is small due to missing of the optimal growth period, loss occurs to farmers, and the breeding production of the river crabs is seriously influenced.
At present, in aquaculture, farmers mostly select chemical drugs such as crystal trichlorfon, furazolidone, terramycin and the like to treat the river crab shaking disease, but the drugs easily cause drug resistance of pathogens and drug residue and pollute aquaculture water.
Disclosure of Invention
The invention aims to solve the technical problems and provide a compound disinfectant for treating river crab shaking diseases, a preparation method and application thereof.
In order to solve the technical problems, the technical scheme provided by the invention is as follows: a compound disinfectant for treating river crab shaking diseases specifically comprises the following components in percentage by weight: 60-68% of polyhexamethylene guanidine, 11-15% of benzalkonium bromide, 7-10% of didodecyldimethylammonium chloride and the balance of pure water.
As an improvement, the mass concentration of the polyhexamethylene guanidine is 25%, the mass concentration of the benzalkonium bromide is 45%, and the mass concentration of the didodecyldimethylammonium chloride is 70%.
A preparation method of a compound disinfectant for treating river crab shaking diseases comprises the following specific steps:
the method comprises the following steps: weighing polyhexamethylene guanidine, benzalkonium bromide and didodecyldimethylammonium chloride according to the weight percentage and the mass concentration percentage;
step two: and (3) adding the polyhexamethylene guanidine, the benzalkonium bromide and the didodecyldimethylammonium chloride in the second step into pure water, and uniformly mixing and stirring.
An application of a compound disinfectant for treating the shaking disease of river crabs in treating the shaking disease of river crabs.
Compared with the prior art, the invention has the advantages that: the invention adopts polyhexamethylene guanidine, which is safe and efficient and has no toxic or side effect; does not generate bacterial drug resistance and is effective for a long time; colorless, tasteless and non-volatile; heavy metal and phenolic substances are not contained; is environment-friendly. By adopting benzalkonium bromide which is a cationic surfactant broad-spectrum bactericide, the permeability of bacterial cytoplasmic membranes can be changed, and bacterial cytoplasmic substances are caused to seep out to block the metabolism of the bacterial cytoplasmic substances to play a role in killing. The didodecyldimethylammonium chloride has low toxicity, low corrosivity and low irritation, can kill various microorganisms such as viruses, bacteria, mold, fungi and the like, has the advantages of no influence of organic pollution on the toxicity-killing capacity, no influence of light, heat, hard water, pH value, temperature, humidity and the like, and long duration of the drug effect. The polyhexamethylene guanidine, the benzalkonium bromide and the didodecyldimethylammonium chloride which belong to the same cationic surfactant are compounded, and are ionized in a water solution to generate strong electropositivity, so that bacteria and viruses with negative charges can be adsorbed, and the sterilization and disinfection effects are better.
Drawings
FIG. 1 is a graph showing a statistical comparison of the treatment effects of the control group and the respective test groups.
Detailed Description
Example one
A compound disinfectant for treating river crab shaking diseases specifically comprises the following components in percentage by weight: 60% of polyhexamethylene guanidine, 15% of benzalkonium bromide, 7% of didodecyldimethylammonium chloride and the balance of pure water.
The mass concentration of the polyhexamethylene guanidine is 25%, the mass concentration of the benzalkonium bromide is 45%, and the mass concentration of the didodecyldimethylammonium chloride is 70%.
A preparation method of a compound disinfectant for treating river crab shaking diseases comprises the following specific steps:
the method comprises the following steps: weighing polyhexamethylene guanidine, benzalkonium bromide and didodecyldimethylammonium chloride according to the weight percentage and the mass concentration percentage;
step two: and (3) adding the polyhexamethylene guanidine, the benzalkonium bromide and the didodecyldimethylammonium chloride in the second step into pure water, and uniformly mixing and stirring.
Example two
A compound disinfectant for treating river crab shaking diseases specifically comprises the following components in percentage by weight: 64% of polyhexamethylene guanidine, 13% of benzalkonium bromide, 8.5% of didodecyldimethylammonium chloride and the balance of pure water.
The mass concentration of the polyhexamethylene guanidine is 25%, the mass concentration of the benzalkonium bromide is 45%, and the mass concentration of the didodecyldimethylammonium chloride is 70%.
A preparation method of a compound disinfectant for treating river crab shaking diseases comprises the following specific steps:
the method comprises the following steps: weighing polyhexamethylene guanidine, benzalkonium bromide and didodecyldimethylammonium chloride according to the weight percentage and the mass concentration percentage;
step two: and (3) adding the polyhexamethylene guanidine, the benzalkonium bromide and the didodecyldimethylammonium chloride in the second step into pure water, and uniformly mixing and stirring.
EXAMPLE III
A compound disinfectant for treating river crab shaking diseases specifically comprises the following components in percentage by weight: 68% of polyhexamethylene guanidine, 11% of benzalkonium bromide, 10% of didodecyldimethylammonium chloride and the balance of pure water.
The mass concentration of the polyhexamethylene guanidine is 25%, the mass concentration of the benzalkonium bromide is 45%, and the mass concentration of the didodecyldimethylammonium chloride is 70%.
A preparation method of a compound disinfectant for treating river crab shaking diseases comprises the following specific steps:
the method comprises the following steps: weighing polyhexamethylene guanidine, benzalkonium bromide and didodecyldimethylammonium chloride according to the weight percentage and the mass concentration percentage;
step two: and (3) adding the polyhexamethylene guanidine, the benzalkonium bromide and the didodecyldimethylammonium chloride in the second step into pure water, and uniformly mixing and stirring. FIG. 1 shows a schematic view of a
Application effect of compound disinfectant for treating river crab shaking disease
Four disease-causing ponds were selected and set as test groups one, two, three (corresponding to example one, example two, example three) and control group (non-treatment group), respectively. Each group is provided with three net cages, 40 diseased river crabs in the pond are cultured and put in each net cage, and the test observation lasts 15 days. During the normal feeding period, the compound disinfectant shown in the example I is used in the test group I, the compound disinfectant shown in the example II is used in the test group II, and the compound disinfectant shown in the example III is used in the test group III, and after being diluted by water, the compound disinfectant is uniformly sprinkled in a whole pool according to the dosage of 250 ml/mu-meter and is three times a day. The control group was not treated. Feeding, time to death and number of deaths were observed and recorded and cumulative mortality was calculated.
Results of the experiment
The experimental result is shown in figure 1, and the experimental result shows that the compound disinfectant can effectively treat the river crab shaking disease. The cumulative mortality of the test groups is lower than that of the control group, the treatment effect of the test group three is most obvious, and the death can be controlled on the fourth day.
The present invention and the embodiments thereof have been described above, and it is within the scope of the present invention that the present invention shall not be limited by the claims of the present invention.
Claims (4)
1. The compound disinfectant for treating the river crab shaking disease is characterized by comprising the following components in percentage by weight: 60-68% of polyhexamethylene guanidine, 11-15% of benzalkonium bromide, 7-10% of didodecyldimethylammonium chloride and the balance of pure water.
2. The compound disinfectant for treating river crab shaking disease according to claim 1, wherein the compound disinfectant comprises: the mass concentration of the polyhexamethylene guanidine is 25%, the mass concentration of the benzalkonium bromide is 45%, and the mass concentration of the didodecyldimethylammonium chloride is 70%.
3. The preparation method of the compound disinfectant for treating the river crab shaking disease according to claim 1, which comprises the following steps:
the method comprises the following steps: weighing polyhexamethylene guanidine, benzalkonium bromide and didodecyldimethylammonium chloride according to the weight percentage and the mass concentration percentage of the components in the claims 1 and 2;
step two: and (3) adding the polyhexamethylene guanidine, the benzalkonium bromide and the didodecyldimethylammonium chloride in the second step into pure water, and uniformly mixing and stirring.
4. The use of the compound disinfectant according to any one of claims 1-2 for treating the shaking disease of river crabs.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN202110593982.XA CN113332310A (en) | 2021-05-28 | 2021-05-28 | Compound disinfectant for treating river crab shaking disease and preparation method and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110593982.XA CN113332310A (en) | 2021-05-28 | 2021-05-28 | Compound disinfectant for treating river crab shaking disease and preparation method and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114652711A (en) * | 2022-03-01 | 2022-06-24 | 吉林省水产技术推广总站(吉林省水产引种育种中心、吉林省水生动物防疫检疫与病害防治中心) | Medicine for treating 'milk disease' of river crab, use method and application |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114652711A (en) * | 2022-03-01 | 2022-06-24 | 吉林省水产技术推广总站(吉林省水产引种育种中心、吉林省水生动物防疫检疫与病害防治中心) | Medicine for treating 'milk disease' of river crab, use method and application |
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