CN108522851A - Eucommia leaf extract and its application in preparing the feed addictive for improving meat rabbit growth performance - Google Patents
Eucommia leaf extract and its application in preparing the feed addictive for improving meat rabbit growth performance Download PDFInfo
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- CN108522851A CN108522851A CN201810747745.2A CN201810747745A CN108522851A CN 108522851 A CN108522851 A CN 108522851A CN 201810747745 A CN201810747745 A CN 201810747745A CN 108522851 A CN108522851 A CN 108522851A
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- leaf extract
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- eucommia leaf
- eucommia
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/111—Aromatic compounds
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/121—Heterocyclic compounds containing oxygen or sulfur as hetero atom
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/50—Feeding-stuffs specially adapted for particular animals for rodents
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Abstract
The present invention provides application of the eucommia leaf extract in preparing the feed addictive for improving meat rabbit growth performance.The present invention is using meat rabbit as research object, the influence by experimental study eucommia ulmoides extracts substitute antibiotics to meat rabbit growth performance.Result of study shows that it is feasible that eucommia leaf extract all or part substitute antibiotics are added in young rabbit daily ration, and can improve meat rabbit production performance, increases economic benefit.The present invention, which tests, determines that addition 200g/t eucommia leaf extracts substitute whole antibiotic in rabbit diet or 100g/t substitutes 50% antibiotic.Eucommia leaf extract chlorogenic acid containing Cortex Eucommiae, eucommia bark polycose and eucommia bark flavone of the present invention have antibacterial, resisting stress, anti-oxidant, the effect of removing free radical, promote growth, promote intestinal beneficial bacterium proliferation, keep intestinal flora balance, improve immunity of organisms；It is a kind of green feed additive efficient, environmentally friendly, safe and free of toxic and side effects of substitute antibiotics.
Description
Technical field
The invention belongs to animal feed additive technical fields, and in particular to eucommia leaf extract and its prepare for carrying
Application in the feed addictive of high meat rabbit growth performance.
Background technology
Antibiotic is widely used in rabbit daily ration at present to prevent disease and promote rabbit growth and development.Since excess is exceeded the time limit
Addition antibiotic causes medicament residue exceeded, brings and seriously affects to health of masses and environment.In May, 2012《Feed
With feed addictive management rules》Execution, stringent specification and limit carried out using kind and dosage to drug in feed
System, forbidding in feed adding antibiotic becomes being necessarily required to for modern cultivation, from people's health demand, find safety,
Green, efficient Substitutes For Antibiotic has become current meat rabbit aquaculture urgent problem to be solved.
Rabbit there are weaning stress, first time physiological moult stress, the unsound physiological phenomenon of enteric microorganism,
Diarrhea easily occurs in production, dead serious problem is generally solved using Multiple Classes of Antibiotics is added in feed in production, right
Human health and environment cause certain harm.
Invention content
The goal of the invention of the present invention is there is provided eucommia leaf extract and its is preparing for improving meat rabbit growth performance
Application in feed addictive.The present invention adds eucommia leaf extract by experiment in rabbit diet, determines that it gives birth to rabbit
Eucommia leaf extract of the present invention, can be added in rabbit daily ration, be a kind of high by long development and anti-diarrhea influence
Effect, nontoxic, substitute antibiotics green feed additive.
For achieving the above object, the present invention is achieved by the following scheme：
The present invention provides a kind of eucommia leaf extract, the eucommia leaf extract includes following components：Cortex Eucommiae chlorogenic acid
3%-8%, eucommia bark flavone 8%-16% and eucommia bark polycose 20%-40%.
The extracting method of the eucommia leaf extract is as follows：
(1) it extracts：Folium cortex eucommiae is weighed, crushes, feeds intake, the water for accounting for 5-10 times of Cortex Eucommiae leaf quality is added, extraction is primary；It adjusts
The pH value of water is 5, adds water, the pH value of second of extraction, water is 5；
(2) alcohol precipitation：The ethyl alcohol that 5-10 times of volume is added into Aqueous extracts carries out polysaccharide precipitation；
(3) it filters：Solution is filtered；
(4) it concentrates：Filtered fluid single-action concentrates, and is concentrated into proportion between 1 and 2；
(5) spray drying：Eucommia leaf extract is made in concentrate spray drying tower spray drying.
The present invention also provides the eucommia leaf extracts to prepare the feed addition for improving meat rabbit growth performance
Application in agent.
Further：100g/t~200g/t eucommia leaf extracts are added in the meat rabbit feed.
Further：200g/t eucommia leaf extracts are added in the meat rabbit feed, significantly improve the average day of meat rabbit
Weightening.
Further：200g/t eucommia leaf extracts are added in the meat rabbit feed, the feed for significantly reducing meat rabbit turns
Rate.
Further：200g/t eucommia leaf extracts are added in the meat rabbit feed, significantly reduce the per kilogram of meat rabbit
Increase weight feed cost.
Compared with prior art, it advantages of the present invention and has the technical effect that：The present invention passes through reality using meat rabbit as research object
Test influence of the research eucommia ulmoides extracts substitute antibiotics to meat rabbit growth performance.Result of study shows to add in young rabbit daily ration
Eucommia leaf extract all or part substitute antibiotics are feasible, and can improve meat rabbit production performance, increase economic effect
Benefit.The present invention, which tests, determines that addition 200g/t eucommia leaf extracts substitute whole antibiotic in rabbit diet or 100g/t is substituted
50% antibiotic.
Eucommia leaf extract chlorogenic acid containing Cortex Eucommiae, eucommia bark polycose and eucommia bark flavone of the present invention, have it is antibacterial, it is anti-to answer
Swash, it is anti-oxidant, free radical is removed, growth is promoted, promotes intestinal beneficial bacterium proliferation, keeps intestinal flora balance, body is improved and exempts from
The effect of epidemic disease power；It is a kind of green feed additive efficient, environmentally friendly, safe and free of toxic and side effects of substitute antibiotics.
Specific implementation mode
Further detailed description is done to technical scheme of the present invention with reference to specific embodiment.
Embodiment 1
The present embodiment is by experimental verification eucommia leaf extract to the influence in terms of meat rabbit growth performance.
1 material and method
Selection, grouping and the experimental period of 1.1 experiment rabbits
The healthy New Zealand son rabbit 300 for selecting the wean in (± 2 days) of 35 ages in days is randomly divided into control group, test group I, examination
Test a group II, test group III and test group IV, every group 60 (male and female is fifty-fifty).Control group adds antibiotic, test group I, test group
II and test group III do not add antibiotic, add eucommia leaf extract 100g/t, 150g/t and 200g/t, test group IV respectively
It adds eucommia leaf extract 100g/t and substitutes 50% antibiotic.It tests 35 ages in days to start, until 70 ages in days terminate.
1.2 test periods, place and trial target
Test period：2 days-May 6 April in 2014,35 days experimental periods.
Test site：Sichuan Agricultural University's teaching and scientific research warren.
The eucommia leaf extract：Its extracting method is as follows：
(1) it extracts：Folium cortex eucommiae 1kg is weighed, 60 mesh is crushed to, feeds intake, 6kg water is added, extraction is primary.The pH value of water is 5,
Add 6kg water, second of extraction；The pH value of water is 5.
(2) alcohol precipitation：Aqueous extracts are added to 6 times of 75% ethyl alcohol and carry out polysaccharide precipitation.
(3) it filters：Solution is crossed into plate-frame filtering.
(4) it concentrates：Filtered fluid single-action concentrates, and is concentrated into proportion 1.2 or so.
(5) spray drying：The eucommia leaf extract is made in concentrate spray drying tower spray drying.
1.3 experimental design
It is designed using single-factor random experiment, experimental design refers to table 1.
1 experimental design of table
1.4 experiment Diet Formulas and trophic level
2 Diet Formula of table and trophic level
1.5 feeding managements are measured with experiment
Every morning 8 cleanings, 9 points start to feed.33 ages in days and 60 ages in days injection rabbit pest and rabbit bar Combined vaccine, 42
Age in days injects clostridieum welchii vaccine, is freely eaten and drinks water.During experiment, meat rabbit diarrhea and death condition are observed and recorded.
2 testing indexs
2.1 weight
2.1.1 35 age in days weight；70 age in days weight.
2.1.2 daily gain=(last weight-starting weight)/experiment number of days
2.2 feed conversion rate
Feed conversion rate=experimental period feed consumption rate/experimental period weightening.
2.3 diarrhea and death condition
Loose stools and watery stool are diarrhea, record diarrhea situation accordingly.
2.3.1 diarrhea rate=young rabbit diarrhea number of elements in experimental period/rabbit number of elements of participating in the experiment.
2.3.2 the death rate=young rabbit death number of elements in experimental period/rabbit number of elements of participating in the experiment.
2.4 feed intake
3 statistical analyses
It is for statistical analysis using SPASS softwares, carry out one-way analysis of variance with ANOVA.
4 results and analysis
Off-test, statistical analysis each group production performance index and economic benefit, experimental result refer to table 3.
3 meat rabbit production performance of table compares
Note：Same column data alphabet difference person indicates significant difference (p ＜ 0.05)
Test result shows：The diarrhea rate of test group I and test group II, the death rate, feed conversion rate and per kilogram weightening
Feed cost is not notable (p ＞ 0.05) with control group difference；The average daily gain of test group III is significantly higher than control group, experiment
Group I and test group II (p ＜ 0.05), per kilogram weightening feed cost are substantially less than control group, test group I and test group II (p ＜
0.05), diarrhea rate, the death rate, feed conversion rate difference is not notable (p ＞ 0.05)；The average daily gain of test group IV is significantly high
In control group, test group I and test group II (p ＜ 0.05), diarrhea rate, the death rate, feed conversion rate and per kilogram weightening feed
Cost is substantially less than control group, test group I and test group II (p ＜ 0.05)；Compared with the control group, test group III averagely increases day by day
Bring up again high by 4.5%, feed conversion rate reduction by 2.3%, per kilogram weightening feed cost reduction by 3%, diarrhea rate and death rate indifference
It is different；Test group IV average daily gains improve 5.0%, and feed conversion rate reduces by 6.4%, and per kilogram weightening feed cost reduces by 6%,
Diarrhea rate reduces by 25.1%, and the death rate reduces by 50%.
This result of study shows that it is practical that eucommia leaf extract all or part substitute antibiotics are added in young rabbit daily ration
It is feasible, and meat rabbit production performance can be improved, increase economic benefit.The present invention, which tests, determines addition 200g/t Du in rabbit diet
Secondary leaf extract substitutes whole antibiotic or 100g/t substitutes 50% antibiotic.
Eucommia leaf extract of the present invention contains chlorogenic acid, polysaccharide and flavones, has antibacterial, resisting stress, anti-oxidant, removes
Free radical promotes growth, the effect of promoting intestinal beneficial bacterium proliferation, keep intestinal flora balance, improve immunity of organisms；It is one
The green feed additive efficient, environmentally friendly, safe and free of toxic and side effects of kind substitute antibiotics.
Eucommia leaf extract main component Cortex Eucommiae chlorogenic acid, primary efficacy is antibacterial anti-inflammatory, to various pathogens and on exhale
Inhaling road Infective virus etc. has significant inhibiting effect.Extracorporeal bacteria inhibitor test the result shows that, to staphylococcus aureus, second
Type streptococcus, Escherichia coli and typhoid bacillus etc. have good inhibiting effect.It in addition can also strengthen immunity, removing free radical
And other effects.Eucommia leaf extract also contains the ingredients such as eucommia bark flavone, eucommia bark polycose, to immune system, internal system, maincenter god
There is different degrees of adjustment effect through system, the circulatory system and urinary system.
The above embodiments are merely illustrative of the technical solutions of the present invention, rather than is limited；Although with reference to aforementioned reality
Applying example, invention is explained in detail, for those of ordinary skill in the art, still can be to aforementioned implementation
Technical solution recorded in example is modified or equivalent replacement of some of the technical features；And these are changed or replace
It changes, the spirit and scope for claimed technical solution of the invention that it does not separate the essence of the corresponding technical solution.
Claims (7)
1. a kind of eucommia leaf extract, it is characterised in that：The eucommia leaf extract includes following components：Cortex Eucommiae chlorogenic acid 3%-
8%, eucommia bark flavone 8%-16% and eucommia bark polycose 20%-40%.
2. eucommia leaf extract according to claim 1, it is characterised in that the extracting method of the eucommia leaf extract is such as
Under：
（1）Extraction：Folium cortex eucommiae is weighed, crushes, feeds intake, the water for accounting for 5-10 times of Cortex Eucommiae leaf quality is added, extraction is primary；Adjust water
PH value is 5, adds water, the pH value of second of extraction, water is 5；
（2）Alcohol precipitation：The ethyl alcohol that 5-10 times of volume is added into Aqueous extracts carries out polysaccharide precipitation；
（3）Filtering：Solution is filtered；
（4）Concentration：Filtered fluid single-action concentrates, and is concentrated into proportion between 1 and 2；
（5）Spray drying：Eucommia leaf extract is made in concentrate spray drying tower spray drying.
3. eucommia leaf extract as claimed in claim 1 or 2 is in preparing the feed addictive for improving meat rabbit growth performance
Application.
4. eucommia leaf extract according to claim 3 is in preparing the feed addictive for improving meat rabbit growth performance
Application, it is characterised in that：100g/t ~ 200g/t eucommia leaf extracts are added in the meat rabbit feed.
5. eucommia leaf extract according to claim 3 is in preparing the feed addictive for improving meat rabbit growth performance
Application, it is characterised in that：200g/t eucommia leaf extracts are added in the meat rabbit feed, significantly improve the average day of meat rabbit
Weightening.
6. eucommia leaf extract according to claim 3 is in preparing the feed addictive for improving meat rabbit growth performance
Application, it is characterised in that：200g/t eucommia leaf extracts are added in the meat rabbit feed, the feed for significantly reducing meat rabbit turns
Rate.
7. eucommia leaf extract according to claim 3 is in preparing the feed addictive for improving meat rabbit growth performance
Application, it is characterised in that：200g/t eucommia leaf extracts are added in the meat rabbit feed, significantly reduce the per kilogram of meat rabbit
Increase weight feed cost.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810747745.2A CN108522851A (en) | 2018-07-09 | 2018-07-09 | Eucommia leaf extract and its application in preparing the feed addictive for improving meat rabbit growth performance |
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| CN201810747745.2A CN108522851A (en) | 2018-07-09 | 2018-07-09 | Eucommia leaf extract and its application in preparing the feed addictive for improving meat rabbit growth performance |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111802527A (en) * | 2020-06-08 | 2020-10-23 | 浙江大学 | Application of eucommia ulmoides extract in preparation of feed for improving delicate flavor of chicken |
| CN114009591A (en) * | 2021-12-17 | 2022-02-08 | 湖南德诺健康产业集团有限公司 | Natural feed additive for improving growth performance and meat quality of livestock and poultry and application thereof |
| CN114027398A (en) * | 2021-12-17 | 2022-02-11 | 湖南德诺健康产业集团有限公司 | Natural feed additive for improving livestock and poultry feed conversion rate and meat quality and application thereof |
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| CN1593188A (en) * | 2004-07-14 | 2005-03-16 | 张家界恒兴生物科技有限公司 | Eucommia feed addictive |
| CN102228133A (en) * | 2011-06-15 | 2011-11-02 | 曹爱智 | Folium cortex eucommiae extract and application thereof |
| CN103829038A (en) * | 2014-03-05 | 2014-06-04 | 张家界恒兴生物科技有限公司 | Novel eucommia feed additive and production method thereof |
| CN105767563A (en) * | 2016-03-11 | 2016-07-20 | 四川农业大学 | Feed for reducing immature-rabbit diarrhea diseases and feeding method of immature rabbit thereof |
| CN106361799A (en) * | 2016-08-31 | 2017-02-01 | 无锡正大生物股份有限公司 | Eucommia leaf extract and preparation method and application thereof |
| CN107865190A (en) * | 2017-12-12 | 2018-04-03 | 四川农业大学 | Improve meat rabbit growth performance and the mixed feed of weaning period son's rabbit survival rate and preparation method thereof |
-
2018
- 2018-07-09 CN CN201810747745.2A patent/CN108522851A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1593188A (en) * | 2004-07-14 | 2005-03-16 | 张家界恒兴生物科技有限公司 | Eucommia feed addictive |
| CN102228133A (en) * | 2011-06-15 | 2011-11-02 | 曹爱智 | Folium cortex eucommiae extract and application thereof |
| CN103829038A (en) * | 2014-03-05 | 2014-06-04 | 张家界恒兴生物科技有限公司 | Novel eucommia feed additive and production method thereof |
| CN105767563A (en) * | 2016-03-11 | 2016-07-20 | 四川农业大学 | Feed for reducing immature-rabbit diarrhea diseases and feeding method of immature rabbit thereof |
| CN106361799A (en) * | 2016-08-31 | 2017-02-01 | 无锡正大生物股份有限公司 | Eucommia leaf extract and preparation method and application thereof |
| CN107865190A (en) * | 2017-12-12 | 2018-04-03 | 四川农业大学 | Improve meat rabbit growth performance and the mixed feed of weaning period son's rabbit survival rate and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111802527A (en) * | 2020-06-08 | 2020-10-23 | 浙江大学 | Application of eucommia ulmoides extract in preparation of feed for improving delicate flavor of chicken |
| CN114009591A (en) * | 2021-12-17 | 2022-02-08 | 湖南德诺健康产业集团有限公司 | Natural feed additive for improving growth performance and meat quality of livestock and poultry and application thereof |
| CN114027398A (en) * | 2021-12-17 | 2022-02-11 | 湖南德诺健康产业集团有限公司 | Natural feed additive for improving livestock and poultry feed conversion rate and meat quality and application thereof |
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