CN111096398A - Feed additive for improving pig immunity and pig antiviral infection capacity - Google Patents
Feed additive for improving pig immunity and pig antiviral infection capacity Download PDFInfo
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- CN111096398A CN111096398A CN201911396971.1A CN201911396971A CN111096398A CN 111096398 A CN111096398 A CN 111096398A CN 201911396971 A CN201911396971 A CN 201911396971A CN 111096398 A CN111096398 A CN 111096398A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/24—Compounds of alkaline earth metals, e.g. magnesium
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
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- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
Abstract
The invention provides a feed additive for improving pig immunity and pig antiviral infection capacity, which comprises 10-30 parts of citrus extract, 10-25 parts of ganoderma lucidum powder, 10-30 parts of polysaccharide, 10-25 parts of iron glycinate chelate, 10-25 parts of magnesium sulfate and 1-5 parts of glutathione, can effectively inhibit virus growth, improve organism immunity, improve organism hematopoietic function, reduce stress, improve organism digestion and absorption functions and the like, can improve individual immunity function, and can prevent and control African swine fever.
Description
Technical Field
The invention relates to the technical field of disease prevention and control, in particular to a feed additive for improving pig immunity and pig antiviral infection capacity.
Background
Along with the improvement of living standard of people, the demand of pork is more and more large, and the requirements on the nutritive value and the edible safety of the pork are also more and more high. With the continuous development of animal husbandry, the breeding quantity of pork pigs in China is continuously increased, but the common breeding feed only can enable the pigs to grow rapidly, but cannot improve the immunity of the pigs, and particularly improves the antiviral infection capacity of the pigs. In recent years, the probability of the pigs being sick is very high, and most of the pigs are dead due to infection caused by pestiviruses. Of these, African swine fever is the most severe.
African Swine Fever (ASF) is a virulent infectious disease caused by infection of domestic and wild pigs by African Swine Fever Virus (ASFV). Pigs of different ages are susceptible, clinically, the symptoms of high fever, skin cyanosis and organ failure are high, and the death rate of acute and subacute diseases reaches 100%. In 8 months in 2018, African swine fever is introduced into China for the first time and then rapidly spread in a large range, which poses a significant threat to the pig industry in China and has extremely severe prevention and control situation. African swine fever viruses mainly affect monocyte-macrophages, ASFV infection typically begins with monocyte-macrophages in the tonsils and mandibular lymph nodes, with lymph and blood circulation to target organs (lymph nodes-bone marrow, spleen, lung, liver and kidney). The pulmonary edema and organ failure of pigs caused by the late stage of acute and subacute African swine fever are the main causes of pig mortality. The researched attenuated live vaccine shows relative effectiveness in clinic, but has the problems of virus dispersion and poor safety; mass production is difficult due to the absence of organelles in non-pesticidally infected cells. Under the influence of epidemic situation of African swine fever, domestic pig stock is greatly reduced, pork is forbidden to be transported and restricted, and meat supply quantity can not meet market demand, so that price is continuously increased. Non-pestiviruses destroy monocytes-macrophages and cause T-cell apoptosis, which is caused by toxins released by non-pestiviruses, and are susceptible in sick pigs due to their own low resistance. The resistance of the pigs is low, and in addition to the low resistance caused by a captive breeding mode, free radicals generated under a stress state have an injury effect on organisms, the updating speed of a blood circulation system is slow, and deposition of endotoxin is also an important factor. Therefore, it is urgently needed to improve the immune function of pigs, improve the antiviral ability and reduce non-pestilence infection by a feed regulation mode.
Patent CN201910350987.2 discloses a feed additive of inorganic salt for preventing and controlling African swine fever, which is prepared by melting, gelatinizing, puffing and compounding soluble inorganic salt with antibacterial function, and on the basis of carrying out strict sterilization and disinfection on a live pig farm, the feed additive is added into pig feed for daily feeding, so that the African swine fever can be prevented and treated; the technical scheme starts from the aspect of supplementing trace elements, has no effects on sterilization and virus killing, has no effects of improving hematopoietic function, discharging vivotoxin and the like, and has certain limitation in the using process.
Therefore, there is a need for a feed additive and a preparation method thereof, which comprises amino acids, vitamins and a part of physiologically active substances as essential substances satisfying life and vital activities, has high safety, has the effects of improving hematopoietic function, discharging vivotoxin and the like, and has a good effect of preventing and controlling African swine fever.
Disclosure of Invention
Aiming at the defects of the prior art, particularly the problem of difficult comprehensive treatment of infectious diseases caused by combining the pathogenesis of African swine fever with poor immune function of organisms and the like, the invention provides the feed additive for improving the immunity of pigs and the antiviral infection capacity of pigs, which can improve the immune function of individuals and effectively prevent and control the African swine fever.
In order to solve the technical problems, the invention provides the following technical scheme:
on one hand, the invention provides a feed additive for improving pig immunity and pig antiviral infection capacity, which comprises, by weight, 10-30 parts of citrus extract, 10-25 parts of ganoderma lucidum powder, 10-30 parts of polysaccharide, 10-25 parts of iron glycine chelate, 10-25 parts of magnesium sulfate and 1-5 parts of glutathione.
Further, the feed additive for improving the pig immunity and the pig antiviral infection capacity comprises, by weight, 20 parts of a citrus extract, 10 parts of ganoderma lucidum powder, 20 parts of polysaccharide, 10 parts of iron glycine chelate, 10 parts of magnesium sulfate and 1 part of glutathione.
Glutathione can improve pig individual immunity, and can improve antioxidant effect and detoxication ability.
The citrus extract is derived from fruit and citrus, is a very safe food-grade raw material, contains a large amount of vitamin C, flavonoids, plant essential oil and other components, and can improve the immunity and the hematopoietic function of the organism.
The ganoderma lucidum can improve the immunity of the organism and greatly improve the hematopoietic function of the organism.
Polysaccharide, the palatability of the feed additive is adjusted, and the feed intake of individual pigs is improved.
Iron is chelated by glycine, which can provide iron element for hematopoiesis and supplement amino acid.
Magnesium sulfate, which provides a beneficial element magnesium.
Further, the preparation method of the citrus extract comprises the following steps:
pulverizing Mandarin orange, extracting with water solution of ethanol and sodium salicylate, standing the obtained mixed solution, and concentrating the supernatant under reduced pressure to obtain Mandarin orange extract. The citrus extract has antioxidant, antiviral, and antibacterial effects.
Further, the citrus is crushed to 80 meshes, 1-5 times volume of 60% ethanol and equal volume of saturated sodium salicylate aqueous solution are used for extracting for 5-12 hours at 50-90 ℃, the obtained mixed solution is kept stand for 12 hours, supernatant is taken and subjected to reduced pressure concentration to form an extract with the volume ratio of 1.0-1.5, and the extract is dried at low temperature.
Further, the orange is crushed to 80 meshes, extracted for 8 hours at 80 ℃ by 5 times volume of 60% ethanol and equal volume of saturated sodium salicylate aqueous solution, the obtained mixed solution is kept stand for 12 hours, supernatant is taken and concentrated under reduced pressure to form an extract with the volume ratio of 1.0-1.5, the solvent is pumped out under reduced pressure at 30-40 ℃, and the low-temperature drying is carried out.
On the other hand, the invention provides a preparation method of the feed additive, which comprises the following specific steps:
the orange extract, the ganoderma lucidum powder, the polysaccharide, the glycine chelated iron, the magnesium sulfate and the glutathione are uniformly mixed and then crushed into 100-mesh and 200-mesh powder to prepare the feed additive.
In another aspect, the invention provides the use of the feed additive, wherein the feed additive is directly added into a pig trough to be fed, and is added together with feed for at least 1 month continuously.
Advantageous effects
Compared with the prior art, the invention has the following beneficial effects:
the invention provides a feed additive for improving pig immunity and pig antiviral infection capacity, which has the following advantages:
the feed additive provided by the invention is prepared by compounding the citrus extract with the ganoderma lucidum powder, the polysaccharide, the glycine chelated iron, the magnesium sulfate and the glutathione according to a proportion, so that the feed additive not only can inhibit the growth of viruses, improve the immunity of an organism, improve the hematopoietic function of the organism, reduce stress, improve the digestion and absorption functions of the organism and the like, but also is safe and pollution-free in each component, edible, strong in inhibition effect on virus propagation and good in prevention and control effect realized by synergistic treatment.
The feed additive provided by the invention has sweet taste of each component, can improve the feed intake of pigs, and simultaneously improve the immunity, so as to improve the control effect of swine fever, thereby finally achieving the purposes of promoting the growth of the pigs, improving the survival rate of swinery, reducing the use of antibiotics and chemical drugs, and improving the economic benefit of households.
The feed additive provided by the invention can realize comprehensive prevention and control of African swine fever, inhibit the spread of diseases among individuals, greatly reduce the death rate of pig bodies, realize the survival rate of over 70 percent when fed in a pig farm with positive detection, and only realize the survival rate of about 10 percent in a blank group.
Detailed Description
The present invention will be described in further detail with reference to specific embodiments, but it should not be construed that the scope of the subject matter of the present invention is limited to the examples.
The process equipment or devices not specifically noted in the following examples are conventional in the art; all reagents are commercially available.
Example 1
A feed additive for improving pig immunity and pig antiviral infection capacity comprises, by weight, 30 parts of citrus extract, 10 parts of ganoderma lucidum powder, 30 parts of polysaccharide, 10 parts of iron glycine chelate, 25 parts of magnesium sulfate and 1 part of glutathione.
The preparation method of the citrus extract comprises the following steps:
pulverizing Mandarin orange to 80 mesh, extracting with 5 volume times of 60% ethanol and equal volume of saturated sodium salicylate water solution at 90 deg.C for 5 hr, standing for 12 hr, collecting supernatant, concentrating under reduced pressure to obtain extract with volume ratio of 1.0-1.5, vacuum drying at 30-40 deg.C to remove solvent, and drying at low temperature.
The preparation method of the feed additive comprises the following specific steps:
the citrus extract, the ganoderma lucidum powder, the polysaccharide, the iron glycine chelate, the magnesium sulfate and the glutathione are uniformly mixed and then crushed to 100 meshes to prepare the feed additive.
Example 2
A feed additive for improving pig immunity and pig antiviral infection capacity comprises, by weight, 10 parts of citrus extract, 25 parts of ganoderma lucidum powder, 10 parts of polysaccharide, 25 parts of iron glycine chelate, 10 parts of magnesium sulfate and 5 parts of glutathione.
The preparation method of the citrus extract comprises the following steps:
pulverizing Mandarin orange to 80 mesh, extracting with 1 volume of 60% ethanol and equal volume of saturated sodium salicylate water solution at 60 deg.C for 12 hr, standing for 12 hr, collecting supernatant, concentrating under reduced pressure to obtain extract with volume ratio of 1.0-1.5, vacuum drying at 30-40 deg.C to remove solvent, and drying at low temperature.
The preparation method of the feed additive comprises the following specific steps:
mixing Mandarin orange extract, Ganoderma powder, polysaccharide, iron glycine chelate, magnesium sulfate, and glutathione, vacuum pumping out solvent at 30-40 deg.C, and pulverizing to 200 mesh to obtain feed additive.
Example 3
A feed additive for improving pig immunity and pig antiviral infection capacity comprises, by weight, 20 parts of citrus extract, 10 parts of ganoderma lucidum powder, 20 parts of polysaccharide, 10 parts of iron glycine chelate, 10 parts of magnesium sulfate and 1 part of glutathione.
The preparation method of the citrus extract comprises the following steps: pulverizing Mandarin orange to 80 mesh, extracting with 5 times volume of 60% ethanol and equal volume of saturated sodium salicylate water solution at 80 deg.C for 8 hr, standing for 12 hr, collecting supernatant, concentrating under reduced pressure to obtain extract with volume ratio of 1.0-1.5, vacuum drying at 30-40 deg.C to remove solvent, and drying at low temperature.
The preparation method of the feed additive comprises the following specific steps:
mixing the citrus extract, the ganoderma lucidum powder, the polysaccharide, the iron glycine chelate, the magnesium sulfate and the glutathione, and crushing to 150 meshes to prepare the feed additive.
Effect experiment 1
In order to verify the application effect of the feed additive, the feed additive is added into a pig trough to be fed, the feed additive and the pig trough are added together, the weight and the growth cycle of the pig are similar, and the pig with positive African swine fever is detected to perform an experiment and divided into a control group, a blank group and an experimental group, wherein each group has 30 heads, the control group is only added with lucid ganoderma powder and glutathione, and the ratio of the lucid ganoderma powder to the glutathione to the lucid ganoderma powder to the glutathione is 10: 1; the blank group is not used any feed additive; the experimental group used the product of any of examples 1-3; and providing living environment and sufficient food during the test period, feeding the pigs three times a day with the feeding amount of 30-120 g, and counting the living condition of the pigs after 30 days.
TABLE 1
| Experiment grouping | Total number of | Number of survivors |
| Control group | 30 | 7 |
| Blank group | 30 | 3 |
| Example 1 | 30 | 20 |
| Example 2 | 30 | 20 |
| Example 3 | 30 | 21 |
The experiments in the table show that the feed additive provided by the invention can effectively prevent and control the African swine fever, inhibit the spread of diseases, has an excellent effect on preventing and controlling the African swine fever, improves the immunity of the organism and realizes the improvement of the survival rate of pigs.
It will be understood that the above embodiments are merely exemplary embodiments taken to illustrate the principles of the present invention, which is not limited thereto. It will be apparent to those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention, and these changes and modifications are also considered to be included in the scope of the invention.
Claims (7)
1. The feed additive for improving pig immunity and pig antiviral infection capacity is characterized by comprising, by weight, 10-30 parts of citrus extract, 10-25 parts of ganoderma lucidum powder, 10-30 parts of polysaccharide, 10-25 parts of iron glycine chelate, 10-25 parts of magnesium sulfate and 1-5 parts of glutathione.
2. The feed additive for improving the pig immunity and the pig antiviral infection capacity according to claim 1, which is characterized by comprising 20 parts of citrus extract, 10 parts of ganoderma lucidum powder, 20 parts of polysaccharide, 10 parts of iron glycine chelate, 10 parts of magnesium sulfate and 1 part of glutathione in percentage by weight.
3. The feed additive for improving pig immunity and pig antiviral infection capability according to claim 1, wherein the citrus extract is prepared by the following method:
pulverizing Mandarin orange, extracting with water solution of ethanol and sodium salicylate, standing the obtained mixed solution, collecting supernatant, concentrating under reduced pressure, and drying to obtain Mandarin orange extract.
4. The feed additive for improving the pig immunity and the pig antiviral infection capacity according to claim 3, wherein the citrus is crushed to 80 meshes, 1-5 times of the volume of 60% ethanol and the same volume of saturated sodium salicylate aqueous solution are used for extracting at 50-90 ℃ for 5-12 hours, the obtained mixed solution is kept still for 12 hours, supernatant is taken and subjected to reduced pressure concentration to obtain an extract with the volume ratio of 1.0-1.5, and the extract is dried at low temperature.
5. The feed additive for improving the pig immunity and the pig antiviral infection capacity according to claim 4, wherein the citrus is crushed to 80 meshes, extracted for 8 hours at 80 ℃ by using 5 times volume of 60% ethanol and equal volume of saturated sodium salicylate aqueous solution, the obtained mixed solution is kept still for 12 hours, then the supernatant is taken and concentrated under reduced pressure to obtain an extract with the volume ratio of 1.0-1.5, the solvent is extracted under reduced pressure at 30-40 ℃, and the extract is dried at low temperature.
6. A preparation method of the feed additive as claimed in any one of claims 1 to 5, which is characterized by comprising the following steps:
mixing citrus extract, Ganoderma powder, polysaccharide, iron glycinate chelate, magnesium sulfate and glutathione, pulverizing, and making into feed additive.
7. Use of the feed additive according to any one of claims 1 to 5, wherein the feed additive is added directly to a trough of pigs to be fed, and added together with the feed, and wherein a single pig is fed with 50 to 200g per day for at least 1 month of continuous treatment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911396971.1A CN111096398A (en) | 2019-12-30 | 2019-12-30 | Feed additive for improving pig immunity and pig antiviral infection capacity |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201911396971.1A CN111096398A (en) | 2019-12-30 | 2019-12-30 | Feed additive for improving pig immunity and pig antiviral infection capacity |
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| CN111096398A true CN111096398A (en) | 2020-05-05 |
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| CN201911396971.1A Pending CN111096398A (en) | 2019-12-30 | 2019-12-30 | Feed additive for improving pig immunity and pig antiviral infection capacity |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114557406A (en) * | 2022-03-18 | 2022-05-31 | 江苏农牧科技职业学院 | Feed additive for improving pig immunity and preparation method thereof |
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| CN104161180A (en) * | 2013-07-18 | 2014-11-26 | 河南联合英伟饲料有限公司 | Feed additive for resisting viral diseases of pigs, preparation method and application |
| CN106387422A (en) * | 2016-09-18 | 2017-02-15 | 胡云龙 | Feed for improving survival rate of piglets |
| CN109221699A (en) * | 2018-08-06 | 2019-01-18 | 山东金城生物药业有限公司 | Reduced glutathione is promoting pig growth and is improving the application in pig health status |
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2019
- 2019-12-30 CN CN201911396971.1A patent/CN111096398A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101390578A (en) * | 2008-10-24 | 2009-03-25 | 厦门百拓生物工程有限公司 | Polysaccharide additive premixing feedstuff for pig |
| CN104161180A (en) * | 2013-07-18 | 2014-11-26 | 河南联合英伟饲料有限公司 | Feed additive for resisting viral diseases of pigs, preparation method and application |
| CN106387422A (en) * | 2016-09-18 | 2017-02-15 | 胡云龙 | Feed for improving survival rate of piglets |
| CN109221699A (en) * | 2018-08-06 | 2019-01-18 | 山东金城生物药业有限公司 | Reduced glutathione is promoting pig growth and is improving the application in pig health status |
Non-Patent Citations (2)
| Title |
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| 崔艺燕 等: "柑橘提取物对仔猪免疫功能的影响", 《动物营养学报》 * |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114557406A (en) * | 2022-03-18 | 2022-05-31 | 江苏农牧科技职业学院 | Feed additive for improving pig immunity and preparation method thereof |
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