CN105248881A - Composite functional traditional Chinese medicine additive and preparation method thereof - Google Patents
Composite functional traditional Chinese medicine additive and preparation method thereof Download PDFInfo
- Publication number
- CN105248881A CN105248881A CN201510759209.0A CN201510759209A CN105248881A CN 105248881 A CN105248881 A CN 105248881A CN 201510759209 A CN201510759209 A CN 201510759209A CN 105248881 A CN105248881 A CN 105248881A
- Authority
- CN
- China
- Prior art keywords
- vitamin
- lentinan
- chinese medicine
- obtains
- enzyme
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention relates to a composite vitamin functional additive and a preparation method thereof, and belongs to the technical field of cultivation nutrition and prevention and treatment of diseases. The additive is prepared from ginseng polysugar, lentinan, various functional vitamins (including fat-soluble vitamin and water-soluble vitamin), amino acid and Chinese herb extract. The preparation method includes the steps that the extracted ginseng polysugar and the lentinan are added into a composite vitamin premix compound for beasts and birds to be mixed; the ginseng polysugar accounts for 8%-10% of the composite vitamin premix compound for beasts and birds, the lentinan accounts for 5% of the composite vitamin premix compound for beasts and birds, and the vitamin mixture accounts for 85%-87% of the composite vitamin premix compound for beasts and birds. By the adoption of the additive, the feed intake and the daily adding weight of beasts and birds can be effectively increased, the vital movement of beasts and birds is maintained, the immunity, disease resistance and anti-stress capacity are improved, nutritional deficiency diseases are prevented, feed consumption is reduced, toxic and side effects are avoided, no adverse effect on the environment is caused, and the utilization rate of the raw materials is greatly increased.
Description
Technical field
The present invention relates to a kind of additive, be specifically related to a kind of interpolation panaxan, lentinan preparation livestock and poultry B B-complex functional additive and preparation method thereof, belong to cultivation nutrition and disease prevention and cure technical field.
Background technology
In recent years, along with the development of modern farming, feed addictive almost for whole production processes of various livestock and poultry, one of three large pillars having become compound-feed industries raw material.Additive is often referred to trophism and the non-nutritive composition of the various trace made an addition in mixed feed.Nutritive additive comprises various vitamin, trace element, amino acid etc., although livestock and poultry are very small to the needs of this constituents, but they are that animal growth and development and the normal institute that produces are requisite, owing to can not synthesize in animal body or synthetic quantity deficiency, this kind of material just must by feed supply.Feed addictive is of a great variety in the market, distinct, and requirement is extremely small, and addition from every tonnage milligram to several grams, and is main in feed mainly with being added into, and this just brings stirring in directly using and homodisperse problem.And Aquavite directly can add in drinking-water, dissolubility is good, there is not the uneven situation of dispersion, greatly facilitates cultivation dealer.
The use of additive plays great effect to raising raising poultry nutritive efficiency and production performance, but general feeds additive is main component mainly with chemical synthetic drug, antibiotic or hormonal substance greatly, lasting use easily causes residual in carcass and drug resistance, even in the livestock products such as meat, egg, milk, also there are medicine and the toxin remains, and have the possibility causing canceration, sudden change, distortion, thus harm humans is healthy, its excreta more can cause the pollution of environment, and these problems have caused worldwide extensive concern.And Chinese herbal feed additive because it is safe and harmless, toxic and side effect is little, noresidue, without the resistance to the action of a drug, lower-price characteristic, day by day be subject to attention both domestic and external, the use of Chinese herbal feed additive, complies with the trend of the world today's " green agriculture ", has DEVELOPMENT PROSPECT widely.
Both at home and abroad, in feed industry and animal and veterinary field, as additive for farm animal feed, a large amount of scientific research and practical work are carried out to Chinese medicine and byproduct thereof, and has achieved good effect.Research shows, Chinese medicine feeds pigs as feed addictive, chicken, ox, sheep, duck, fish, deer, dove, fox, racoon dog, rabbit etc., the physiological function of body can not only be regulated, enhance metabolism, and there is the function of clearing heat and detoxicating, anti-inflammation, expelling parasite and develop immunitypty, to the quickening speed of growth, improve production performance, improve the aspects such as product quality and all have obvious facilitation.
China is vast in territory, and Chinese medicine is of a great variety, aboundresources, low price, can gather materials on the spot, and has and develops the advantageous condition of Chinese herbal feed additive.According to document announcement, that commonly uses animal doctor more than 1000 plants in Chinese medicine, about has more than 500 to plant and uses as feed addictive, various places sequential trial also have developed many Chinese herbal feed additives, in various Production of Livestock and Poultry, all have application, Chinese medicine, as feed addictive, has wide DEVELOPMENT PROSPECT.
As far back as the sixties in last century; the various active of ginseng, lentinan is found; the various biological activity such as the immunological regulation of various polysaccharides of traditional Chinese medicine subsequently, antitumor, hypoglycemic, reducing blood lipid, anti-oxidant, anti-ageing, antiviral, protection gastronintestinal system are proved gradually, find that LBP-X, GL-B, grifolan, tremella polysaccharides, redemption behavior, ophiopogonpolysaccharide just have antitumor, immunity moderation, the anti-ageing effect of waiting for a long time by research.
The molecular weight of polysaccharide is general all very large, and traditional method is all that ginseng, mushroom, the Radix Astragali, Poria cocos, white fungus, Hericium erinaceus, these Chinese herbal medicines being rich in polysaccharide of matrimony vine are boiled soup and eat, and common decocting method can only make the polysaccharide of about 1% molten in soup; If directly eaten, enteron aisle is also limited to the absorption of macromolecular polysaccharides of traditional Chinese medicine.So only have by specific extraction process, a large amount of polysaccharide obtained in Chinese herbal medicine, and then make and be easy to absorbed preparation, body can add to polysaccharides of traditional Chinese medicine quickly and easily, immunity moderation system, thus reach ' healthy tendency deposit in, heresy can not be done '.Secondly, past, a lot of people queried the validity of polysaccharides of traditional Chinese medicine, thought that small intestine can not absorb polysaccharides of traditional Chinese medicine, but research discovery lentinan directly can be absorbed at small intestine, and oral is the effective way of polysaccharides of traditional Chinese medicine.
Sugar or glucide are polyhydroxyl aldehyde or polyhydroxyketone compound, and their condensation polymer or derivative, also referred to as carbohydrate.Monose is the basic composition unit of sugar, and 2 ~ 10 monose composition oligosaccharides, more than 10 then form polysaccharide.And complex polysaccharide filters out science, effective polysaccharide combination, the combination collocation carried out with optimal proportion, has the effect of " 1+1 ﹥ 2 ".
The bioactivity research of polysaccharide:
Regulate, strengthen immunologic function: lentinan, tremella polysaccharides, Cordyceps sinensis polysaccharide, pachymaran, GL-B, panaxan, licorice polysaccharide, LBP-X, red jujube polysaccharide, astragalus polyose, Bupleurum chinense polysaccharide, plantago asiatica linne polyoses, Radix Et Caulis Acanthopanacis Senticosi polysaccharide, Radix Angelicae Sinensis polysaccharide etc.
Antitumor: Radix Et Caulis Acanthopanacis Senticosi polysaccharide, pachymaran, LBP-X, laminarin, astragalus polyose, GL-B, lentinan, tremella polysaccharides, coriolan etc.
Antiviral, antibacterial: Banlangen Polysaccharide, garlic polysaccharide, licorice polysaccharide, Rhodiola Sachinensis A. Bor Polysaccarides, Siberian solomonseal rhizome polysaccharide, astragalus polyose, Inokopolyose, lentinan, grifolan, fructus hippophae polysaccharide, Hijiki polysaccharide, laver amylose etc.
Delay senility, anti-oxidant: Hedyotidis Diffusae polysaccharide, Scutellaria Barbata D. Don Polysaccharides, Fructus Schisandrae Polysaccharide, Radix Angelicae Sinensis polysaccharide, LBP-X, GL-B, adenophora tetraphylla polysaccharide, Fructus Ligustri Lucidi polysaccharide, Taraxacum Polysaccharides, Polysaccharides from Prunella vulgaris L, tremella polysaccharides etc.
Anti-inflammatory, antiallergy, as tuber gourd fruit polysaccharide, pachymaran, astragalus polyose, flammulina velutipes, GL-B, ophiopogonpolysaccharide, anemaran etc.
Radioresistance: Radix Angelicae Sinensis polysaccharide, LBP-X, laminarin, Blackfungus polyhexose, astragalus polyose, GL-B, panaxan etc.
Regulate cardio-cerebrovascular Cordyceps sinensis polysaccharide, rhubarb polyoses, mankshood polysaccharide, LBP-X, laminarin, thunder godvine polysaccharide, GL-B, sea lettuce polysaccharide, gastrodia elata polysaccharide etc.
Regulate digestive system: conk polyose, aloe polysaccharide, pilose antler polysaccharides, astragalus polyose, soluble polysaccharide, LBP-X, polysaccharides from ginkgo biloba, panaxan, Kiwi berry polysaccharide, Fructus Schisandrae Polysaccharide, rhubarb polyoses, Bupleurum chinense polysaccharide, Radix Angelicae Sinensis polysaccharide, Hericium erinaceus Polysaccharides etc.
Protect the liver: Cordyceps sinensis polysaccharide, Radix Et Caulis Acanthopanacis Senticosi polysaccharide, Radix Angelicae Sinensis polysaccharide, pachymaran, LBP-X, laminarin, Hericium erinaceus Polysaccharides, astragalus polyose, redemption behavior, lentinan etc.
Analgesia: Radix Angelicae Sinensis polysaccharide, eucommia bark polycose, grifolan, Fructus Schisandrae Polysaccharide etc.
Chinese invention " a kind of compound polysaccharide feed stuff additive and application thereof ", application number 200910192559.8 discloses a kind of feed addictive prescription be made up of panaxan, lentinan and flammulina velutipes, but does not keep healthy prophylactic effect; Chinese invention " a kind of glycan feed additive ", application number 200910111367.x discloses the feed addictive that one is 0.1 ~ 50.0% immune polysaccharide containing percentage by weight; Chinese invention " feed Chinese medicine additive ", application number 201110168203.8 discloses in a kind of feed and adds traditional Chinese medicine ingredients, and trace element, amino acid, vitamin proportioning feed addictive, but there is no effect that is disease-resistant, immunity moderation.
Visible, functional vitamin additive is in the market main mainly with B B-complex or B B-complex amino acid or simple Chinese herbal compounds, function ratio is more single, multivitamin, amino acid and kinds of traditional Chinese medicines extract is adopted to be composited, play and can supplement the nutrients, can be kept healthy again prophylactic effect, and the Chinese medicine composite functional additive of a medicine multipotency have not been reported.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composite functional additive and preparation method thereof, formula of the present invention overcomes that to there is feed nutrition in the finished product feedstuff using feed market to sell or the daily ration prepared voluntarily with premix not comprehensive, effective ingredient is not enough and unbalanced problem, it is the additive of ideal protein amino acid system, maintain and need of production according to animal physiological completely, and provide the appropriate various essential amino acids that can directly absorb, the present invention one medicine multipotency, easy to use, with low cost, and the infection of the various bacteria virus vitamin that livestock and poultry can be prevented common, improve immunity and premunition.
A kind of Chinese medicine composite functional additive, be made up of the component of following weight portion:
Vitamin A 800 ~ 1,200 ten thousand IU, vitamine D3 80 ~ 1,200,000 IU, vitamin E 8 ~ 12g, VB11 ~ 3g, vitamin B2 3 ~ 5g, calcium pantothenate 8 ~ 12g, vitamin B6 1 ~ 2g, Catergen 0 ~ 30g, Vitamin K3 1 ~ 2g, glutamic acid 80 ~ 90mg, folic acid 400 ~ 600mg, niacin 10 ~ 30g, isoleucine 20 ~ 25g, methionine 30 ~ 60g, lysine 30 ~ 60g, alanine 11 ~ 13g, arginine 14 ~ 16g, aspartic acid 25 ~ 30g, cystine 1 ~ 2.5g, valine 25 ~ 30g, glycine 7 ~ 9g, histidine 10 ~ 12g, leucine 30 ~ 40g, phenylalanine 17 ~ 20g, proline 35 ~ 40g, serine 20 ~ 30g, threonine 15 ~ 20g, tryptophan 5 ~ 8g, panaxan 80 ~ 100g, lentinan 50g, auxiliary material DEXTROSE ANHYDROUS adds to 1000g.
A kind of Chinese medicine composite functional additive, be made up of the component of following weight portion:
Retinol1 0,000,000 IU, vitamine D3 1,000,000 IU, vitamin e1 0g, vitamin B12 g, vitamin B2 4g, calcium pantothenate 10g, vitamin B6 1.5g, Catergen 5g, Vitamin K3 1.5g, glutamic acid 85mg, folic acid 500mg, niacin 20g, isoleucine 23.6g, methionine 50g, lysine 50g, alanine 12.96g, arginine 15.6g, aspartic acid 27.8g, cystine 1.9g, valine 27.8g, glycine 8g, histidine 11.8g, leucine 35.4g, phenylalanine 19g, proline 3 9.2g, serine 24g, threonine 18.6g, tryptophan 6.4g, panaxan 100g, lentinan 50g, auxiliary material DEXTROSE ANHYDROUS adds to 1000g.
Present invention also offers a kind of preparation method of Chinese medicine composite functional additive, comprise the steps:
(1) extraction of panaxan:
A. ginseng is cleaned after drying, through cutting into slices, pulverizing, sieve, obtain ginseng pulverate;
B. soak at room temperature 20 ~ 200 minutes after ginseng pulverate being mixed with pure water, ultrasonic extraction 22 ~ 30 minutes, obtains extract;
C. said extracted liquid is filtered, supernatant is evaporated to 1/3 ~ 1/2 of original volume, obtains concentrate;
D. in concentrate, add the ethanol of mass concentration 95 ~ 98%, addition is 5 ~ 8 times of concentrate volume, and normal temperature leaves standstill 2 ~ 4 hours, obtains sediment;
E. by sediment freeze drying, pulverized 60 orders and obtained panaxan's powder;
(2) extraction of lentinan:
A. will cross the mushroom powder of 80 ~ 100 order granularities, 1 ~ 1.5h is soaked in 50 ~ 55 DEG C of water-baths, regulates PH to 6.5 ~ 6.8, obtains mushroom solution;
B. the ratio of papain, cellulase 2:1 is by mass percentage mixed into complex enzyme, addition is 0.3% of mushroom powder dry mass, and the water-soluble solution of complex enzyme obtains 1 ‰ enzyme liquid;
C. mushroom solution is put and is preheated to hydrolysis temperature 55 ~ 58 DEG C in a water bath, is joined in mushroom solution by enzyme liquid, constant temperature oscillator extracts 1-3h;
D. by extracting liquid filtering, filtrate is put in boiling water pot, and 10 ~ 15min boiling water bath goes out enzyme, obtains zyme extract;
E. zyme extract is cooled to room temperature, puts in centrifuge, centrifuging and taking supernatant, namely obtains enzyme and extracts polysaccharide liquid;
F. enzyme is extracted polysaccharide liquid to concentrate, dry, pulverize 60 ~ 80 mesh sieves, namely obtain lentinan powder;
(3) take vitamin A, vitamine D3, vitamin E, vitamin B1, vitamin B2, calcium pantothenate, vitamin B6, vitamin C, Vitamin K3, glutamic acid, folic acid, niacin, isoleucine, methionine, lysine, alanine, arginine, aspartic acid, cystine, valine, glycine, histidine, leucine, phenylalanine, proline, serine, threonine, tryptophan, panaxan, lentinan add that DEXTROSE ANHYDROUS is to full dose, fully mix, obtain Chinese medicine composite functional additive.
The solution temperature of ultrasonic extraction described in step (1) b is 30 ~ 50 DEG C, ultrasonic power 150 ~ 200 watts.
Step (1) (2) carry out in cleaning shop, and purity requirements is 300,000 grades, and other steps are carried out in GMP workshop.
The invention has the beneficial effects as follows: adopt several functions vitamin (comprising liposoluble vitamin and water soluble vitamin) and amino acid, Chinese medical extract is composited; Panaxan adopts ultrasonic extraction, freeze drying, lentinan adopts and adds multiplex-enzyme extraction, leaching process easily realizes, fully after mixing, and the coefficient of variation≤10%, compared with conventional method, extraction time save 2/3rds, extraction efficiency improve twice, wherein in panaxan galacturonic acid content more than 30%; Coordinative role with each pharmacodynamic raw materials can effectively improve livestock and poultry feed intake and adding weight, maintain the normal activities of kind of livestock and poultry, improve immunity, resistance against diseases and anti-stress ability, prevention deficiency disease, improve kind of a livestock and poultry production performance, reduce food consumption, reduce the generation of livestock and poultry, mutually complementary and the toxic and side effect weakened when each pharmacodynamic raw materials is used alone and bad reaction between raw material, have no side effect, environment is had no adverse effect, greatly improve the utilization rate of each pharmacodynamic raw materials.
One. the application in domestic animal:
1. prevention and therapy vitamin and amino acid starvation disease, muscular dystrophy, as stress phase and gravidic nutritional supplementation, the death of prevention newborn animal lactation and weak young number, improve gaining effect.
2. improve conception rate and the farrowing rate of breeding stock, prevent anaemia and anorexia.
3. increase appetite, eliminate prevention of sow constipation, eliminate udder edema, promote lactation function, weight after raising weaned piglet.
4. promote that sow normally oestruses, shorten breeding interval, shortening labor.
5. promote male animal sexual desire, improve ejaculate volume and sperm quality.
6. play the prophylactic effect of health care, the generation of prevention mammitis, hysteritis and bacterial disease viral disease simultaneously.
Two. the application in poultry:
1. prevention and therapy vitamin and amino acid starvation disease, muscular dystrophy, as stress the nutritional supplementation of phase and laying period, prevents young fowl dead and reduce weak young number, increases young fowl appetite, improve gaining effect.
2. improve laying rate, rate of fertilization, the incubation rate of kind of fowl, and improve eggshell quality and painted.
3. pair laying rate declines gradually, and produce soft-shelled egg, shell egg or white shell egg, egg diminishes, and lopsided egg, shell egg, soft-shelled egg, husky lime-preserved egg, the thick situation such as shell egg and little egg have tall and erect effect.
4. play the prophylactic effect of health care, prevention kind of fowl oaritis, salpingitis, peritonitis, apocamnosis of raising in cages, fatty liver syndrome, egg drop syndrome simultaneously.
5. the bacterium of laying eggs is affected on ewcastle disease, bird flu, egg drop syndrome, infective bronchitis etc. and viral disease has good auxiliary therapeutic action.
Scientific research finds: the ratio of animal to ideal amino acid is relative constancy, affects very little, the growth of follower by factors such as kind, sex and ages in days, the just various amino acid whose absolute demand amount of change, and mutual ratio remains unchanged substantially.Formula of the present invention can for animal provide balance, suitable proportion, the various essential amino acids being benchmark with methionine, lysine and tryptophan limiting amino acid that can directly absorb.Like this, as long as with the addition of the daily ration amino acid ratio balance of additive of the present invention, thering is provided of this over-all peace weighing apparatus gal4 amino acid, just maximally can improve the amino acid whose utilization rate of feed protein, as long as the amount of satisfying the demand, the nutritional need needed for animal growth and growing and fattening just can be ensured.
Additive of the present invention is the additive of best vitamin requirement target, best vitamin requirement target makes animal in modern management, himself genetic potential is given full play to and necessary under room and Disease epizootic condition, also by the vitamin such as vitamin A and vitamin D control and activate animal body inner growth hormone (as 1,25-(OH) 2D3) gene and the synthesis of growth promoting effects hormone (growth hormone, cortex hormone of aadrenaline etc. as anteriorpituitary secretion) and secretion and short long weightening finish.The present invention's formula had both met vitamin needs amount and the PLP(phosphopyridoxal pyridoxal phosphate by the promotion thiamine pyrophosphate (TPP) of vitamin B1, the FMN (FMN) of vitamin B2 and flavin adenine dinucleotide (FAD) enzyme (FAD), vitamin B6) albumen dependence enzyme, the effect of the enzymes such as the adenosylcobalamin coenzyme of vitamin B12, more can effectively promote digesting and assimilating of feed nutrition material, meet body growth to grow, the nutritional need of growing and fattening.
Growing and fattening, increase weight and improve production performance of livestock and poultry can be promoted fast, supplement the essential amino acid based on limiting amino acid, daily ration amino acid and body amino acid requirement ratio is made to be in balance, improve food conversion ratio to greatest extent, ensure the getting fat weightening finish of animal, improve daily gain, shorten and raise the time limit; Optimum vitamin needs amount is provided, except giving full play to genetic potential, the activity of animal body inner growth hormone gene and the synthesis of growth promoting effects hormone can also be activated, realize enhancing development and the object of fattening that increases weight.
The present invention can make the protein amino acid balance in feed, and breaks down proteins is that amino acid is abundant, discharges so can reduce over many nitrogen in metabolism with the form of uric acid and urea, reduces the consumption of ATP and alleviate stress; Vitamin A, E can suppress the release of glucocorticoid in body, adrenaline and prostaglandin; Vitamin E reduces too much calcium ion and flows in cell and reduce stress reaction.
The present invention can strengthen the disease resistance of body after using: one is realized by the approach of raising body nonspecific reaction and specific immunity effect, as vitamin A can promote epithelial cell growth, differentiation and integrality, thus improve the immune system of internal body and outside organization's opposing cause of disease invasion and non-antigen systems, comprise phagocytosis, periphery lymphocyte catches and location, the dissolving of natural killer cell, maintains the nonspecific reaction of leucocyte lysozyme activity etc.Can maintain the function of the immunoblastic lymphoma tissues such as thymus gland, marrow and the bursa of farbricius as vitamin A, accelerating lymphocyte differentiation is the process of T cell and B cell and the generation of amount, improves the specific function of Immune Function and humoral immunity level.Vitamin E can increase spleen weight, makes synthetic antibody cytosis and macrophage increase and improve the realization of red cell agglutination titre etc.Two is the raisings by supplementary amino acid and feed protein digestibility, increase the basic substance protein of antibody synthesis, protein, amino acid whose deficiency, circulating antibody can be reduced and support antimicrobial energy, immune system is very high to egg, essence, a word used in person's names amino acid and vitamin E and vitamin C required amount, so can improve premunition.
Detailed description of the invention
Be described in further details the present invention below by example, these examples are only used for the present invention is described, do not limit the scope of the invention.
Embodiment 1
A kind of Chinese medicine composite functional additive, be made up of the component of following weight portion:
Vitamin A 8,000,000 IU, vitamine D3 800,000 IU, vitamin E 8g, VB11 g, vitamin B2 3g, calcium pantothenate 8g, vitamin B6 1g, Catergen 0g, Vitamin K3 1g, glutamic acid 80mg, folic acid 400mg, niacin 10g, isoleucine 20g, methionine 30g, lysine 30g, alanine 11g, arginine 14g, aspartic acid 25g, cystine 1g, valine 25g, glycine 7g, histidine 10g, leucine 30g, phenylalanine 17g, proline 3 5g, serine 20g, threonine 15g, tryptophan 5g, panaxan 80g, lentinan 50g, auxiliary material DEXTROSE ANHYDROUS adds to 1000g.
A preparation method for Chinese medicine composite functional additive, comprises the steps:
(1) extraction of panaxan:
A. ginseng is cleaned after drying, through cutting into slices, pulverizing, sieve, obtain ginseng pulverate;
B. soak at room temperature 20 minutes after ginseng pulverate being mixed with pure water, solution temperature be 30 DEG C, under ultrasonic power 150 watts, ultrasonic extraction 22 minutes, obtains extract;
C. said extracted liquid is filtered, supernatant is evaporated to 1/3 of original volume, obtains concentrate;
D. in concentrate, add the ethanol of mass concentration 95%, addition is 5 times of concentrate volume, and normal temperature leaves standstill 2 hours, obtains sediment;
E. by sediment freeze drying, pulverized 60 orders and obtained panaxan's powder;
(2) extraction of lentinan:
A. will cross the mushroom powder of 80 order granularities, 1h is soaked in 50 DEG C of water-baths, regulates PH to 6.5, obtains mushroom solution;
B. the ratio of papain, cellulase 2:1 is by mass percentage mixed into complex enzyme, complex enzyme addition is 0.3% of mushroom powder dry mass, and the water-soluble solution of complex enzyme obtains 1 ‰ enzyme liquid;
C. mushroom solution is put and is preheated to hydrolysis temperature 55 DEG C in a water bath, is joined in mushroom solution by enzyme liquid, constant temperature oscillator extracts 1h;
D. by extracting liquid filtering, filtrate is put in boiling water pot, and 10min boiling water bath goes out enzyme, obtains zyme extract;
E. zyme extract is cooled to room temperature, puts in centrifuge, centrifuging and taking supernatant, namely obtains enzyme and extracts polysaccharide liquid;
F. enzyme is extracted polysaccharide liquid to concentrate, dry, pulverize 60 mesh sieves, namely obtain lentinan powder;
(3) take vitamin A, vitamine D3, vitamin E, vitamin B1, vitamin B2, calcium pantothenate, vitamin B6, vitamin C, Vitamin K3, glutamic acid, folic acid, niacin, isoleucine, methionine, lysine, alanine, arginine, aspartic acid, cystine, valine, glycine, histidine, leucine, phenylalanine, proline, serine, threonine, tryptophan, panaxan, lentinan add that DEXTROSE ANHYDROUS is to full dose, fully mix, obtain Chinese medicine composite functional additive;
Step (1) (2) carry out in cleaning shop, and purity requirements is 300,000 grades, and other steps are carried out in GMP workshop.
Embodiment 2
A kind of Chinese medicine composite functional additive, be made up of the component of following weight portion:
Retinol1 2,000,000 IU, vitamine D3 1,200,000 IU, vitamin e1 2g, orotic acid g, vitamin B2 5g, calcium pantothenate 12g, vitamin B6 2g, vitamin C 30g, Vitamin K3 2g, glutamic acid 90mg, folic acid 600mg, niacin 30g, isoleucine 25g, methionine 60g, lysine 60g, alanine 13g, arginine 16g, aspartic acid 30g, cystine 2.5g, valine 30g, glycine 9g, histidine 12g, leucine 40g, phenylalanine 20g, proline-4 0g, serine 30g, threonine 20g, tryptophan 8g, panaxan 100g, lentinan 50g, auxiliary material DEXTROSE ANHYDROUS adds to 1000g.
A preparation method for Chinese medicine composite functional additive, comprises the steps:
(1) extraction of panaxan:
A. ginseng is cleaned after drying, through cutting into slices, pulverizing, sieve, obtain ginseng pulverate;
B. soak at room temperature 200 minutes after ginseng pulverate being mixed with pure water, solution temperature be 50 DEG C, under ultrasonic power 200 watts, ultrasonic extraction 30 minutes, obtains extract;
C. said extracted liquid is filtered, supernatant is evaporated to 1/2 of original volume, obtains concentrate;
D. in concentrate, add the ethanol of mass concentration 98%, addition is 8 times of concentrate volume, and normal temperature leaves standstill 4 hours, obtains sediment;
E. by sediment freeze drying, pulverized 60 orders and obtained panaxan's powder;
(2) extraction of lentinan:
A. will cross the mushroom powder of 100 order granularities, 1.5h is soaked in 55 DEG C of water-baths, regulates PH to 6.8, obtains mushroom solution;
B. the ratio of papain, cellulase 2:1 is by mass percentage mixed into complex enzyme, complex enzyme addition is 0.3% of mushroom powder dry mass, and the water-soluble solution of complex enzyme obtains 1 ‰ enzyme liquid;
C. mushroom solution is put and is preheated to hydrolysis temperature 58 DEG C in a water bath, is joined in mushroom solution by enzyme liquid, constant temperature oscillator extracts 2h;
D. by extracting liquid filtering, filtrate is put in boiling water pot, and 15min boiling water bath goes out enzyme, obtains zyme extract;
E. zyme extract is cooled to room temperature, puts in centrifuge, centrifuging and taking supernatant, namely obtains enzyme and extracts polysaccharide liquid;
F. enzyme is extracted polysaccharide liquid to concentrate, dry, pulverize 80 mesh sieves, namely obtain lentinan powder;
(3) take vitamin A, vitamine D3, vitamin E, vitamin B1, vitamin B2, calcium pantothenate, vitamin B6, vitamin C, Vitamin K3, glutamic acid, folic acid, niacin, isoleucine, methionine, lysine, alanine, arginine, aspartic acid, cystine, valine, glycine, histidine, leucine, phenylalanine, proline, serine, threonine, tryptophan, panaxan, lentinan add that DEXTROSE ANHYDROUS is to full dose, fully mix, obtain Chinese medicine composite functional additive;
Step (1) (2) carry out in cleaning shop, and purity requirements is 300,000 grades, and other steps are carried out in GMP workshop.
Embodiment 3
A kind of Chinese medicine composite functional additive, be made up of the component of following weight portion:
Retinol1 0,000,000 IU, vitamine D3 1,000,000 IU, vitamin e1 0g, vitamin B12 g, vitamin B2 4g, calcium pantothenate 10g, vitamin B6 1.5g, Catergen 5g, Vitamin K3 1.5g, glutamic acid 85mg, folic acid 500mg, niacin 20g, isoleucine 23.6g, methionine 50g, lysine 50g, alanine 12.96g, arginine 15.6g, aspartic acid 27.8g, cystine 1.9g, valine 27.8g, glycine 8g, histidine 11.8g, leucine 35.4g, phenylalanine 19g, proline 3 9.2g, serine 24g, threonine 18.6g, tryptophan 6.4g, panaxan 100g, lentinan 50g, auxiliary material DEXTROSE ANHYDROUS adds to 1000g.
A preparation method for Chinese medicine composite functional additive, comprises the steps:
(1) extraction of panaxan:
A. ginseng is cleaned after drying, through cutting into slices, pulverizing, sieve, obtain ginseng pulverate;
B. soak at room temperature 100 minutes after ginseng pulverate being mixed with pure water, solution temperature be 40 DEG C, under ultrasonic power 180 watts, ultrasonic extraction 26 minutes, obtains extract;
C. said extracted liquid is filtered, supernatant is evaporated to 1/3 of original volume, obtains concentrate;
D. in concentrate, add the ethanol of mass concentration 95%, addition is 6 times of concentrate volume, and normal temperature leaves standstill 3 hours, obtains sediment;
E. by sediment freeze drying, pulverized 60 orders and obtained panaxan's powder;
(2) extraction of lentinan:
A. will cross the mushroom powder of 100 order granularities, 1h is soaked in 50 DEG C of water-baths, regulates PH to 6.5, obtains mushroom solution;
B. the ratio of papain, cellulase 2:1 is by mass percentage mixed into complex enzyme, complex enzyme addition is 0.3% of mushroom powder dry mass, and the water-soluble solution of complex enzyme obtains 1 ‰ enzyme liquid;
C. mushroom solution is put and is preheated to hydrolysis temperature 55 DEG C in a water bath, is joined in mushroom solution by enzyme liquid, constant temperature oscillator extracts 3h;
D. by extracting liquid filtering, filtrate is put in boiling water pot, and 10min boiling water bath goes out enzyme, obtains zyme extract;
E. zyme extract is cooled to room temperature, puts in centrifuge, centrifuging and taking supernatant, namely obtains enzyme and extracts polysaccharide liquid;
F. enzyme is extracted polysaccharide liquid to concentrate, dry, pulverize 60 mesh sieves, namely obtain lentinan powder;
(3) take vitamin A, vitamine D3, vitamin E, vitamin B1, vitamin B2, calcium pantothenate, vitamin B6, vitamin C, Vitamin K3, glutamic acid, folic acid, niacin, isoleucine, methionine, lysine, alanine, arginine, aspartic acid, cystine, valine, glycine, histidine, leucine, phenylalanine, proline, serine, threonine, tryptophan, panaxan, lentinan add that DEXTROSE ANHYDROUS is to full dose, fully mix, obtain Chinese medicine composite functional additive;
Step (1) (2) carry out in cleaning shop, and purity requirements is 300,000 grades, and other steps are carried out in GMP workshop.
Embodiment 4
A kind of Chinese medicine composite functional additive, be made up of the component of following weight portion:
Vitamin A 9,000,000 IU, vitamine D3 900,000 IU, vitamin E 9g, VB11 .5g, vitamin B2 3.5g, calcium pantothenate 9g, vitamin B6 1.25g, Catergen 2g, Vitamin K3 1.25g, glutamic acid 83mg, folic acid 450mg, niacin 15g, isoleucine 21g, methionine 37g, lysine 37g, alanine 11.5g, arginine 14.5g, aspartic acid 26g, cystine 1.5g, valine 26g, glycine 7.5g, histidine 10.5g, leucine 33g, phenylalanine 18g, proline 3 6g, serine 22g, threonine 17g, tryptophan 6g, panaxan 85g, lentinan 50g, auxiliary material DEXTROSE ANHYDROUS adds to 1000g.
A preparation method for Chinese medicine composite functional additive, comprises the steps:
(1) extraction of panaxan:
A. ginseng is cleaned after drying, through cutting into slices, pulverizing, sieve, obtain ginseng pulverate;
B. soak at room temperature 60 minutes after ginseng pulverate being mixed with pure water, solution temperature be 35 DEG C, under ultrasonic power 160 watts, ultrasonic extraction 24 minutes, obtains extract;
C. said extracted liquid is filtered, supernatant is evaporated to 1/3 of original volume, obtains concentrate;
D. in concentrate, add the ethanol of mass concentration 96%, addition is 6 times of concentrate volume, and normal temperature leaves standstill 2.5 hours, obtains sediment;
E. by sediment freeze drying, pulverized 60 orders and obtained panaxan's powder;
(2) extraction of lentinan:
A. will cross the mushroom powder of 90 order granularities, 1h is soaked in 52 DEG C of water-baths, regulates PH to 6.6, obtains mushroom solution;
B. the ratio of papain, cellulase 2:1 is by mass percentage mixed into complex enzyme, complex enzyme addition is 0.3% of mushroom powder dry mass, and the water-soluble solution of complex enzyme obtains 1 ‰ enzyme liquid;
C. mushroom solution is put and is preheated to hydrolysis temperature 56 DEG C in a water bath, is joined in mushroom solution by enzyme liquid, constant temperature oscillator extracts 2h;
D. by extracting liquid filtering, filtrate is put in boiling water pot, and 12min boiling water bath goes out enzyme, obtains zyme extract;
E. zyme extract is cooled to room temperature, puts in centrifuge, centrifuging and taking supernatant, namely obtains enzyme and extracts polysaccharide liquid;
F. enzyme is extracted polysaccharide liquid to concentrate, dry, pulverize 70 mesh sieves, namely obtain lentinan powder;
(3) take vitamin A, vitamine D3, vitamin E, vitamin B1, vitamin B2, calcium pantothenate, vitamin B6, vitamin C, Vitamin K3, glutamic acid, folic acid, niacin, isoleucine, methionine, lysine, alanine, arginine, aspartic acid, cystine, valine, glycine, histidine, leucine, phenylalanine, proline, serine, threonine, tryptophan, panaxan, lentinan add that DEXTROSE ANHYDROUS is to full dose, fully mix, obtain Chinese medicine composite functional additive;
Step (1) (2) carry out in cleaning shop, and purity requirements is 300,000 grades, and other steps are carried out in GMP workshop.
Embodiment 5
A kind of Chinese medicine composite functional additive, be made up of the component of following weight portion:
Retinol1 1,000,000 IU, vitamine D3 1,100,000 IU, vitamin e1 1g, vitamin B12 .5g, vitamin B2 4.5g, calcium pantothenate 11g, vitamin B6 2g, Catergen 8g, Vitamin K3 2g, glutamic acid 88mg, folic acid 550mg, niacin 25g, isoleucine 24g, methionine 52g, lysine 52g, alanine 13g, arginine 16g, aspartic acid 28g, cystine 2g, valine 28g, glycine 9g, histidine 12g, leucine 37g, phenylalanine 19g, proline 3 8g, serine 27g, threonine 19g, tryptophan 7g, panaxan 95g, lentinan 50g, auxiliary material DEXTROSE ANHYDROUS adds to 1000g.
A preparation method for Chinese medicine composite functional additive, comprises the steps:
(1) extraction of panaxan:
A. ginseng is cleaned after drying, through cutting into slices, pulverizing, sieve, obtain ginseng pulverate;
B. soak at room temperature 150 minutes after ginseng pulverate being mixed with pure water, solution temperature be 45 DEG C, under ultrasonic power 190 watts, ultrasonic extraction 28 minutes, obtains extract;
C. said extracted liquid is filtered, supernatant is evaporated to 1/2 of original volume, obtains concentrate;
D. in concentrate, add the ethanol of mass concentration 97%, addition is 7 times of concentrate volume, and normal temperature leaves standstill 3.5 hours, obtains sediment;
E. by sediment freeze drying, pulverized 60 orders and obtained panaxan's powder;
(2) extraction of lentinan:
A. will cross the mushroom powder of 100 order granularities, 1.5h is soaked in 54 DEG C of water-baths, regulates PH to 6.7, obtains mushroom solution;
B. the ratio of papain, cellulase 2:1 is by mass percentage mixed into complex enzyme, complex enzyme addition is 0.3% of mushroom powder dry mass, and the water-soluble solution of complex enzyme obtains 1 ‰ enzyme liquid;
C. mushroom solution is put and is preheated to hydrolysis temperature 57 DEG C in a water bath, is joined in mushroom solution by enzyme liquid, constant temperature oscillator extracts 1.5h;
D. by extracting liquid filtering, filtrate is put in boiling water pot, and 14min boiling water bath goes out enzyme, obtains zyme extract;
E. zyme extract is cooled to room temperature, puts in centrifuge, centrifuging and taking supernatant, namely obtains enzyme and extracts polysaccharide liquid;
F. enzyme is extracted polysaccharide liquid to concentrate, dry, pulverize 70 mesh sieves, namely obtain lentinan powder;
(3) take vitamin A, vitamine D3, vitamin E, vitamin B1, vitamin B2, calcium pantothenate, vitamin B6, vitamin C, Vitamin K3, glutamic acid, folic acid, niacin, isoleucine, methionine, lysine, alanine, arginine, aspartic acid, cystine, valine, glycine, histidine, leucine, phenylalanine, proline, serine, threonine, tryptophan, panaxan, lentinan add that DEXTROSE ANHYDROUS is to full dose, fully mix, obtain Chinese medicine composite functional additive;
Step (1) (2) carry out in cleaning shop, and purity requirements is 300,000 grades, and other steps are carried out in GMP workshop.
Test with Additive On Chickens of the present invention, boar, its result of the test is as follows:
One, the impact of meat chicken production performance is tested:
1 test material and method
1.1 test material
1.1.1 experimental animal
80 ages in days soil Yellow Chicken (110 ages in days are delivered for sale); The fast large-scale Sanhuang broiler of 30 age in days (56 ages in days are delivered for sale).
1.1.2 test specimen
The present invention fills a prescription I, formula II, formula III; Speed mends 14; Wei Te mends; Brute force is visitd and is admittedly relaxed.
1.2 test sites: Guangxi Yulin;
1.3 experimental design
Choose 80 age in days soil Yellow Chicken 1200, be divided into 6 processed group at random, often organize 200, control group fed basal diet, 5 test group are fed basal diet, and the brute force of adding 1g in the morning with afternoon in drinking-water respectively visit admittedly relax, the present invention fills a prescription I, formula II, formula III, connect and feed 7 days, 14 days experimental periods.
1.4 feeding and management
Adopt conventional feeding and management.
1.5 testing indexs and method
1.5.1 production performance: weighed in units of individuality at 1,7,14 day respectively, and every day calculates feed consumption rate.
Calculate average feed intake, average daily gain and the price of deed.
1.6 data statistic analysis
Test data with average ± standard error (
± SE) represent, carry out one-way analysis of variance through SPSS14.0 statistical software, make Multiple range test by LSD method.
2 test results and analysis
The impact of the average daily ingestion amount of 2.1 Additive On Chickens of the present invention
Table 1 Additive On Chickens feed intake of the present invention affect g/ only
| Group | Control group | Brute force is visitd and is admittedly relaxed | Speed mends 14 | Additive formulations I of the present invention | Additive formulations II of the present invention | Additive formulations III of the present invention |
| 1 ~ 7 day | 52.29±1.41d | 59.46±1.39ac | 56.71±2.00cd | 60.57±2.31ac | 66.64±2.53b | 63.21±2.36ab |
| 8 ~ 14 days | 63.21±2.54ac | 66.32±2.54bc | 65.71±1.29ab | 59.89±1.54a | 70.00±2.44b | 68.00±1.64bc |
| 1 ~ 14 day | 57.75±2.06d | 62.89±1.69ac | 61.21±1.69acd | 60.23±1.33ad | 68.32±1.75b | 65.61±1.53bc |
Note: the 1. complete different person of same rower letter, represents significant difference (P<0.05); Containing same letter or non-marking-up mother person, represent difference not significantly (P>0.05); 2. following table herewith.
Result represents, in testing site, Guangxi (as table 1): 1 ~ 7 day, formula II comparatively control group, brute force visits group of admittedly relaxing, speed benefit 14, I significant difference of filling a prescription (P < 0.05), average daily ingestion amount improves 27.44%, 12.08%, 17.51%, 10.02% respectively, but not remarkable with formula III difference; Formula III comparatively control group, speed mend 14 improve 20.88% respectively, 11.46%(P < 0.05); It is remarkable that formula I, speed benefit 14 and brute force visit each group difference that admittedly relaxes, but all high than control group.8 ~ 14 days, formula II and brute force visit admittedly relax, speed mends 14, III difference of filling a prescription is not remarkable, improve 5.55% respectively, 6.53%, 2.94%(P > 0.05), with control group, fill a prescription I improve 10.74% respectively, 16.88%(P < 0.05).Between all the other groups, difference is remarkable, but III the highest to fill a prescription.Raise from the full phase, comparatively control group, brute force visit group of admittedly relaxing to formula II, speed mends 14, formula I improves 18.30% respectively, 8.63%, 7.11%, 13.43%(P < 0.05), improve 4.13%(P > 0.05 with formula III), formula III and brute force visit admittedly relax, speed mend 14 improve 4.33% respectively, 7.19%(P > 0.05).
The impact of 2.2 Additive On Chickens average daily gains of the present invention
Table 2 Additive On Chickens average daily gain of the present invention affect g/ only
| Group | Control group | Brute force is visitd and is admittedly relaxed | Speed mends 14 | Additive formulations I of the present invention | Additive formulations II of the present invention | Additive formulations III of the present invention |
| 1 ~ 7 day | 10.61±0.55c | 13.39±0.59b | 14.21±0.52b | 16.84±0.67a | 16.22±0.66a | 17.56±0.52a |
| 8 ~ 14 days | 13.59±0.58a | 14.48±0.85ab | 14.65±0.83ab | 13.63±0.51a | 16.03±0.50b | 13.81±0.68a |
| 1 ~ 14 day | 12.16±0.37d | 13.95±0.49c | 14.41±0.51bc | 15.29±0.37ab | 16.15±0.46a | 15.67±0.44a |
Result represents, in testing site, Guangxi (as table 3): comparatively control group, brute force visit group of admittedly relaxing, speed mends 14 significant differences (P < 0.05) for average daily gain in 1 ~ 7 day formula I, formula II, formula III, 58.72%, 52.87%, 65.50% is improve respectively compared with control group, with brute force visit admittedly relax compared with improve 25.77%, 21.13%, 31.14% respectively, 18.51%, 14.14%, 23.57% is improve respectively compared with mending 14 with speed, formula I, between formula II and formula III, difference is remarkable, but III the highest to fill a prescription.8 ~ 14 days, average daily gain formula II comparatively control group, formula I and formula III improve respectively 17.95%, 17.61% and 16.08%(P < 0.05), mends 14 with speed, brute force visit admittedly easyproly improve 9.49% respectively, 10.70%(P > 0.05).Raise from the full phase, average daily gain formula II, formula III comparatively control group, brute force visit admittedly relax, speed mends 14 othernesses significantly (P < 0.05), 32.81%, 28.82% is improve respectively compared with control group, with brute force visit admittedly relax compared with improve 15.77%, 12.33% respectively, improve 12.07%, 8.74% respectively compared with mending 14 with speed.Formula I, between formula II and formula III, difference is remarkable, but average daily gain is II the highest to fill a prescription.
The impact of 2.3 Additive On Chickens feed-weight ratio of the present invention
The impact (Guangxi Yulin) of table 3 Additive On Chickens feed-weight ratio of the present invention
| Group | Control group | Brute force is visitd and is admittedly relaxed | Speed mends 14 | Additive formulations I of the present invention | Additive formulations II of the present invention | Additive formulations III of the present invention |
| 1 ~ 7 day | 4.93±0.09c | 4.44±0.08bc | 3.99±0.19ab | 3.60±0.21a | 4.11±0.11ab | 3.60±0.21a |
| 8 ~ 14 days | 4.65±0.09 | 4.64±0.09 | 4.49±0.12 | 4.39±0.09 | 4.37±0.10 | 4.92±0.06 |
| 1 ~ 14 day | 4.78±0.08b | 4.53±0.06ab | 4.24±0.14ab | 3.97±0.23a | 4.24±0.08ab | 4.23±0.38ab |
Result represents, 1 ~ 7 day, and it is remarkable that formula I, formula II, formula III and speed mend 14 feed-weight ratio differences, but with fill a prescription I and formula III minimum, formula II is the highest.8 ~ 14 days, each group difference of feed-weight ratio was remarkable, but II minimum to fill a prescription.Raise situation from full phase, it is remarkable that formula I, formula II, formula III and speed mend 14 feed-weight ratio differences, but I minimum to fill a prescription.
3, conclusion
3.1 cumulated volume tests, add additive of the present invention and can improve average daily ingestion amount and average daily gain, and reduce feed-weight ratio, improve economic benefit in drinking-water.And it is II the most remarkable to fill a prescription.
Observe in 3.2 tests and find, adds additive of the present invention and respectively organize its body condition of test chicken comparatively control group is better, all can accelerate growth, improve the glossy degree of hair color, bright in color, promote that hat is red with hat greatly.
Two, additive on sow production performance impact test of the present invention
1, materials and methods
1.1 test materials, time and place
The experimental animal expected date of childbirth, 212 in-pigs in 27 days-March 22 February in 2015, is provided by Lian Yu Co., Ltd of Foshan City.
Test additive: additive of the present invention
Test period: on May 5,15 days ~ 2015 January in 2015
1.2 test groupings and process
212 sow stochastic averagina are divided into 2 groups, and test group adds additive of the present invention in feed, and control group does not add any additive.Product testing consumption situation sees the following form 4.
Table 4 is tested and is added scale
| Time | Test group (g/T) | Control group (g/T) |
| 15 days ~ January 29 January in 2015 | 500 | 0 |
| 30 days ~ February 12 January in 2015 | 0 | 0 |
| 13 days ~ February 26 February in 2015 | 500 | 0 |
| 27 days ~ March 5 February in 2015 | 0 | 0 |
| On March 6th, 2015 ~ farrowing | 500 | 0 |
1.3 testing index
Number born per litter, nest young number all alive, live young all weight, weak young rate, still birth rate, mummy rate and abnormal rate.
1.4 data processing
Biometric analysis is carried out to result of the test.
1.5 result of the tests see the following form 5
The impact of table 5 additive on sow production performance of the present invention
| Group | Nest number | Number born per litter/head | Nest young number/head all alive | The equal young weight/kg of nest | Weak young rate/% | Still birth rate/% | Mummy tire/% | Abnormal rate/% |
| Test group | 106 | 12.11±2.83 | 11.36±2.45 | 1.54±0.23 | 2.18 | 4.52 | 1.71 | 0 |
| Control group | 106 | 11.91±3.07 | 10.96±2.77 | 1.42±0.26 | 5.71 | 5.55 | 2.06 | 0 |
Table 6 additive of the present invention is on the impact of birth weaned piglets
| Group | Nest number | Produce survival number/head | Produce a number/head | Survival rate % | Produce weight kg | Turn group's nest mean head % | Turn the equal weight kg of group |
| Test group | 106 | 1162 | 1062 | 91 | 7.072 | 10.42 | 13.32 |
| Control group | 106 | 1152 | 1028 | 89 | 6.777 | 9.88 | 13.18 |
1.6 analysis of experiments
As seen from Table 5, the number born per litter of test group, nest all live young number and young all weight of living all higher than control group; The test group birth weak young rate of piglet, still birth rate, mummy rate and abnormal rate decrease 3.53% than control group, 1.03%, 0.35%, 0.32% respectively.Illustrate that in-pig uses additive of the present invention obviously can reduce the incidence of disease of birth piglet, and then improve the production performance of sow.
As seen from the table, the survival rate of test group piglet is higher than control group by 2%, average individual WEIGHT RATIO Comparative group height 0.14kg.The growing state of the piglet of visible test group is obviously better than control group piglet.
Claims (6)
1. a Chinese medicine composite functional additive, is characterized in that: be made up of the component of following weight portion:
Vitamin A 800 ~ 1,200 ten thousand IU, vitamine D3 80 ~ 1,200,000 IU, vitamin E 8 ~ 12g, VB11 ~ 3g, vitamin B2 3 ~ 5g, calcium pantothenate 8 ~ 12g, vitamin B6 1 ~ 2g, Catergen 0 ~ 30g, Vitamin K3 1 ~ 2g, glutamic acid 80 ~ 90mg, folic acid 400 ~ 600mg, niacin 10 ~ 30g, isoleucine 20 ~ 25g, methionine 30 ~ 60g, lysine 30 ~ 60g, alanine 11 ~ 13g, arginine 14 ~ 16g, aspartic acid 25 ~ 30g, cystine 1 ~ 2.5g, valine 25 ~ 30g, glycine 7 ~ 9g, histidine 10 ~ 12g, leucine 30 ~ 40g, phenylalanine 17 ~ 20g, proline 35 ~ 40g, serine 20 ~ 30g, threonine 15 ~ 20g, tryptophan 5 ~ 8g, panaxan 80 ~ 100g, lentinan 50g, auxiliary material DEXTROSE ANHYDROUS adds to 1000g.
2. a Chinese medicine composite functional additive, is characterized in that: be made up of the component of following weight portion:
Retinol1 0,000,000 IU, vitamine D3 1,000,000 IU, vitamin e1 0g, vitamin B12 g, vitamin B2 4g, calcium pantothenate 10g, vitamin B6 1.5g, Catergen 5g, Vitamin K3 1.5g, glutamic acid 85mg, folic acid 500mg, niacin 20g, isoleucine 23.6g, methionine 50g, lysine 50g, alanine 12.96g, arginine 15.6g, aspartic acid 27.8g, cystine 1.9g, valine 27.8g, glycine 8g, histidine 11.8g, leucine 35.4g, phenylalanine 19g, proline 3 9.2g, serine 24g, threonine 18.6g, tryptophan 6.4g, panaxan 100g, lentinan 50g, auxiliary material DEXTROSE ANHYDROUS adds to 1000g.
3. a preparation method for Chinese medicine composite functional additive, is characterized in that: comprise the steps:
(1) extraction of panaxan:
A. ginseng is cleaned after drying, cut into slices, pulverize, sieve, obtain ginseng pulverate;
B. soak at room temperature 20 ~ 200 minutes after ginseng pulverate being mixed with pure water, ultrasonic extraction 22 ~ 30 minutes, obtains extract;
C. said extracted liquid is filtered, supernatant is evaporated to 1/3 ~ 1/2 of original volume, obtains concentrate;
D. in concentrate, add the ethanol of mass concentration 95 ~ 98%, addition is 5 ~ 8 times of concentrate volume, and normal temperature leaves standstill 2 ~ 4 hours, obtains sediment;
E. by sediment freeze drying, pulverized 60 orders and obtained panaxan's powder;
(2) extraction of lentinan:
A. will cross the mushroom powder of 80 ~ 100 order granularities, 1 ~ 1.5h is soaked in 50 ~ 55 DEG C of water-baths, regulates PH to 6.5 ~ 6.8, obtains mushroom solution;
B. the ratio of papain, cellulase 2:1 is by mass percentage mixed into complex enzyme, the water-soluble solution of complex enzyme obtains the enzyme liquid that concentration is 1 ‰;
C. mushroom solution is put and is preheated to hydrolysis temperature 55 ~ 58 DEG C in a water bath, is joined in mushroom solution by enzyme liquid, constant temperature oscillator extracts 1-3h;
D. by extracting liquid filtering, filtrate is put in boiling water pot, and 10 ~ 15min boiling water bath goes out enzyme, obtains zyme extract;
E. zyme extract is cooled to room temperature, puts in centrifuge, centrifuging and taking supernatant, namely obtains enzyme and extracts polysaccharide liquid;
F. enzyme is extracted polysaccharide liquid to concentrate, dry, pulverize 60 ~ 80 mesh sieves, namely obtain lentinan powder;
(3) take vitamin A, vitamine D3, vitamin E, vitamin B1, vitamin B2, calcium pantothenate, vitamin B6, vitamin C, Vitamin K3, glutamic acid, folic acid, niacin, isoleucine, methionine, lysine, alanine, arginine, aspartic acid, cystine, valine, glycine, histidine, leucine, phenylalanine, proline, serine, threonine, tryptophan, panaxan, lentinan add that DEXTROSE ANHYDROUS is to full dose, fully mix, obtain Chinese medicine composite functional additive.
4. the preparation method of a kind of Chinese medicine composite functional additive according to claim 3, is characterized in that: the solution temperature of ultrasonic extraction described in step (1) b is 30 ~ 50 DEG C, ultrasonic power 150 ~ 200 watts.
5. the preparation method of a kind of Chinese medicine composite functional additive according to claim 3, is characterized in that: described in step (2) b, complex enzyme addition is 0.3% of mushroom powder dry mass.
6. the preparation method of a kind of Chinese medicine composite functional additive according to claim 3, is characterized in that: step (1) (2) carry out in cleaning shop, and purity requirements is 300,000 grades, and other steps are carried out in GMP workshop.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510759209.0A CN105248881A (en) | 2015-11-10 | 2015-11-10 | Composite functional traditional Chinese medicine additive and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510759209.0A CN105248881A (en) | 2015-11-10 | 2015-11-10 | Composite functional traditional Chinese medicine additive and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105248881A true CN105248881A (en) | 2016-01-20 |
Family
ID=55089080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510759209.0A Pending CN105248881A (en) | 2015-11-10 | 2015-11-10 | Composite functional traditional Chinese medicine additive and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105248881A (en) |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105519493A (en) * | 2016-01-28 | 2016-04-27 | 云龙庆明孵化科技有限公司 | Breeding method of geese |
| CN105852063A (en) * | 2016-04-18 | 2016-08-17 | 安徽坤大生物工程技术有限公司 | Sargassum fusiforme polysaccharide-rich nutrition and health care product |
| CN106541482A (en) * | 2016-09-29 | 2017-03-29 | 阜南县星光工艺品有限公司 | A kind of preparation method of formaldehydeless fire-resistant-chipboard |
| CN107594132A (en) * | 2017-10-30 | 2018-01-19 | 赣州播恩生物技术股份有限公司 | The feed addictive of pigling immunity can be improved |
| CN107821790A (en) * | 2017-11-30 | 2018-03-23 | 福建九为生物技术有限公司 | A kind of glycine creep mixed feed for piglets |
| CN107960543A (en) * | 2017-11-30 | 2018-04-27 | 福建九为生物技术有限公司 | A kind of suckling piglet glycine type additive premix |
| CN108041299A (en) * | 2017-11-30 | 2018-05-18 | 福建九为生物技术有限公司 | A kind of nonreactive compound feed for piglets |
| CN108651739A (en) * | 2018-07-30 | 2018-10-16 | 豆蕊米（成都）农业科技集团有限公司 | A kind of addition traditional Chinese medicine ingredients improve the formula for pig forage and preparation method thereof of resistance |
| CN110403111A (en) * | 2019-09-04 | 2019-11-05 | 贵州初好农业科技开发有限公司 | A kind of production method of roxburgh rose beverage |
| CN112655836A (en) * | 2020-12-18 | 2021-04-16 | 广西北海市旺海生物科技有限公司 | Compound feed beneficial to improving bone strength of broiler chicken |
| CN113080465A (en) * | 2021-04-23 | 2021-07-09 | 江苏金维氨生物工程有限公司 | Functional compound amino acid additive |
| CN113142398A (en) * | 2021-04-27 | 2021-07-23 | 张自力 | Functional feed additive for ruminants and preparation method thereof |
| CN113367247A (en) * | 2021-01-05 | 2021-09-10 | 安徽科技学院 | Feed additive for preventing broiler chicken myogastric and glandular gastritis |
| CN114601030A (en) * | 2022-04-02 | 2022-06-10 | 山西农业大学 | Polysaccharide composition for improving animal immunity and production performance and application thereof |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5410174A (en) * | 1977-06-17 | 1979-01-25 | Masaru Takeuchi | Feed producing method |
| CN101250234A (en) * | 2008-04-10 | 2008-08-27 | 北京联合大学生物化学工程学院 | Method for extracting ginseng polysaccharide |
| CN101669582A (en) * | 2009-09-22 | 2010-03-17 | 张永亮 | Compound polysaccharide feed stuff additive and application thereof |
| CN101669578A (en) * | 2009-09-24 | 2010-03-17 | 北京福乐维生物技术有限公司 | High efficiency livestock and poultry nutrition replenisher and preparation method thereof |
| CN102715390A (en) * | 2012-05-03 | 2012-10-10 | 湖北炎帝农业科技股份有限公司 | Liver-protecting functional food and preparation method thereof |
| CN103283977A (en) * | 2013-06-19 | 2013-09-11 | 苏兴 | Chinese herbal medicine compound amino acid feed additive and preparation method thereof |
| CN103652369A (en) * | 2013-12-04 | 2014-03-26 | 北京福乐维生物科技股份有限公司 | General-purpose livestock nano nutritional agent having anti-stress function and preparation method of the nutritional agent |
| CN104206732A (en) * | 2014-09-03 | 2014-12-17 | 河南牧翔动物药业有限公司 | Nutritional enhancer for pigs and poultry |
| CN104381602A (en) * | 2014-10-27 | 2015-03-04 | 广东金品动物营养有限公司 | Compound premix feed granules specially used for commercial poultry as well as preparation method and application of compound premix feed granules |
-
2015
- 2015-11-10 CN CN201510759209.0A patent/CN105248881A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5410174A (en) * | 1977-06-17 | 1979-01-25 | Masaru Takeuchi | Feed producing method |
| CN101250234A (en) * | 2008-04-10 | 2008-08-27 | 北京联合大学生物化学工程学院 | Method for extracting ginseng polysaccharide |
| CN101669582A (en) * | 2009-09-22 | 2010-03-17 | 张永亮 | Compound polysaccharide feed stuff additive and application thereof |
| CN101669578A (en) * | 2009-09-24 | 2010-03-17 | 北京福乐维生物技术有限公司 | High efficiency livestock and poultry nutrition replenisher and preparation method thereof |
| CN102715390A (en) * | 2012-05-03 | 2012-10-10 | 湖北炎帝农业科技股份有限公司 | Liver-protecting functional food and preparation method thereof |
| CN103283977A (en) * | 2013-06-19 | 2013-09-11 | 苏兴 | Chinese herbal medicine compound amino acid feed additive and preparation method thereof |
| CN103652369A (en) * | 2013-12-04 | 2014-03-26 | 北京福乐维生物科技股份有限公司 | General-purpose livestock nano nutritional agent having anti-stress function and preparation method of the nutritional agent |
| CN104206732A (en) * | 2014-09-03 | 2014-12-17 | 河南牧翔动物药业有限公司 | Nutritional enhancer for pigs and poultry |
| CN104381602A (en) * | 2014-10-27 | 2015-03-04 | 广东金品动物营养有限公司 | Compound premix feed granules specially used for commercial poultry as well as preparation method and application of compound premix feed granules |
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105519493A (en) * | 2016-01-28 | 2016-04-27 | 云龙庆明孵化科技有限公司 | Breeding method of geese |
| CN105852063A (en) * | 2016-04-18 | 2016-08-17 | 安徽坤大生物工程技术有限公司 | Sargassum fusiforme polysaccharide-rich nutrition and health care product |
| CN106541482A (en) * | 2016-09-29 | 2017-03-29 | 阜南县星光工艺品有限公司 | A kind of preparation method of formaldehydeless fire-resistant-chipboard |
| CN107594132B (en) * | 2017-10-30 | 2021-02-02 | 播恩集团股份有限公司 | Feed additive capable of improving immunity of piglets |
| CN107594132A (en) * | 2017-10-30 | 2018-01-19 | 赣州播恩生物技术股份有限公司 | The feed addictive of pigling immunity can be improved |
| CN107821790A (en) * | 2017-11-30 | 2018-03-23 | 福建九为生物技术有限公司 | A kind of glycine creep mixed feed for piglets |
| CN107960543A (en) * | 2017-11-30 | 2018-04-27 | 福建九为生物技术有限公司 | A kind of suckling piglet glycine type additive premix |
| CN108041299A (en) * | 2017-11-30 | 2018-05-18 | 福建九为生物技术有限公司 | A kind of nonreactive compound feed for piglets |
| CN108041299B (en) * | 2017-11-30 | 2020-12-29 | 福建九为生物技术有限公司 | Antibiotic-free piglet compound feed |
| CN107960543B (en) * | 2017-11-30 | 2020-12-29 | 福建九为生物技术有限公司 | Glycine-type additive premix feed for piglets |
| CN108651739A (en) * | 2018-07-30 | 2018-10-16 | 豆蕊米（成都）农业科技集团有限公司 | A kind of addition traditional Chinese medicine ingredients improve the formula for pig forage and preparation method thereof of resistance |
| CN110403111A (en) * | 2019-09-04 | 2019-11-05 | 贵州初好农业科技开发有限公司 | A kind of production method of roxburgh rose beverage |
| CN112655836A (en) * | 2020-12-18 | 2021-04-16 | 广西北海市旺海生物科技有限公司 | Compound feed beneficial to improving bone strength of broiler chicken |
| CN113367247A (en) * | 2021-01-05 | 2021-09-10 | 安徽科技学院 | Feed additive for preventing broiler chicken myogastric and glandular gastritis |
| CN113367247B (en) * | 2021-01-05 | 2023-11-14 | 安徽科技学院 | Feed additive for preventing stomach proventriculitis of broiler chickens |
| CN113080465A (en) * | 2021-04-23 | 2021-07-09 | 江苏金维氨生物工程有限公司 | Functional compound amino acid additive |
| CN113142398A (en) * | 2021-04-27 | 2021-07-23 | 张自力 | Functional feed additive for ruminants and preparation method thereof |
| CN114601030A (en) * | 2022-04-02 | 2022-06-10 | 山西农业大学 | Polysaccharide composition for improving animal immunity and production performance and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105248881A (en) | Composite functional traditional Chinese medicine additive and preparation method thereof | |
| CN101313731B (en) | Anti-stress feedstuff additive | |
| CN107319211A (en) | A kind of hirudinaria manillensis young perfect compound feed and preparation method thereof | |
| CN102919607B (en) | Chinese herbal medicine compound feed additive with anti-diarrhea function and improving pork quality | |
| CN101524114A (en) | Egg modified feed additive of plant polysaccharide and flavonoid extracts | |
| CN106721023A (en) | Increase the feed of piglet resistance | |
| CN104206710A (en) | Traditional Chinese medicinal feed additive containing N-carbamylglutamic acid, and its application | |
| CN109717329A (en) | A kind of river crab water-tolerant feed and preparation method thereof | |
| CN108771016A (en) | One boar Chinese herbal feed additive and its application | |
| CN106804904A (en) | A kind of cow feed additive of Chinese herbal medicine | |
| CN102726615A (en) | Vitamin E and trace element selenium aqueous solution and preparation method thereof | |
| CN105028911A (en) | Chinese medicinal herb feed additive containing Dendrobium officinale and feed containing additive | |
| CN101524113A (en) | Compound feed additive of plant polysaccharide and flavonoid extracts | |
| CN114586898A (en) | Feed additive for relieving young poultry transportation stress and preparation method and application thereof | |
| Ladokun et al. | Performance and egg quality characteristics of egg-type chickens as influenced by fluted pumpkin (Telfaria occidentalis) leaf extract | |
| KR20220006183A (en) | Feed additive using herbal medicine and method for manufacturing thereof | |
| Wady et al. | Effect of Adding Different Levels of Water Extract of the Pumpkin Leaves and Pumpkin Seeds Powder (Cucurbita moschata) in Some of The Productive Characteristics of Broiler | |
| CN104940371A (en) | Chinese herbal medicine immunopotentiator for groupers | |
| CN105232678A (en) | Traditional Chinese medicine granules capable of increasing egg yield of laying hens and preparing method thereof | |
| CN111096398A (en) | Feed additive for improving pig immunity and pig antiviral infection capacity | |
| CN104814269A (en) | Method for preparing feed additive from plant waste | |
| CN1836541A (en) | Chinese medicinal herb feedstuff additive for fowl and livestock | |
| CN104322905A (en) | Pig feed containing fennel dregs and preparation method thereof | |
| RU2817414C1 (en) | Method for improving immune status of young pigs using phytocomposition | |
| CN108576405A (en) | A kind of pure natural feed for increasing yield and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160120 |