CN101669578A - High efficiency livestock and poultry nutrition replenisher and preparation method thereof - Google Patents

High efficiency livestock and poultry nutrition replenisher and preparation method thereof Download PDF

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CN101669578A
CN101669578A CN200910092775A CN200910092775A CN101669578A CN 101669578 A CN101669578 A CN 101669578A CN 200910092775 A CN200910092775 A CN 200910092775A CN 200910092775 A CN200910092775 A CN 200910092775A CN 101669578 A CN101669578 A CN 101669578A
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vitamin
grams
high efficiency
livestock
cobastab
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CN101669578B (en
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计成
马秋刚
孙智勇
范文娜
曹爱青
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Beijing Fule Life Support Technology Co ltd
Linyi Fule Life Support Technology Co ltd
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BEIJING FUWISH BIOTECHNOLOGY Co Ltd
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Abstract

The invention provides a high efficiency livestock and poultry nutrition replenisher and a preparation method thereof, and the nutrition replenisher contains various vitamins, amino acids and electrolyte. Simultaneously, the multi-stage premixing process is adopted by the high efficiency livestock and poultry nutrition replenisher, so that the high mixing uniformity of ultra-trace elements can beensured; and furthermore, sanguinarine is introduced into drinking water nutrition replenisher and is processed by peridium treatment, and emulsification treatment is carried out on liposoluble vitamins, so that good water-solubility can be guaranteed. The high efficiency livestock and poultry nutrition replenisher has comprehensive nutrition, leads all nutrient components to be supplemented witheach other, can effectively prevent deficiency of the vitamins and the amino acids, maintains electrolyte balance, regulates the metabolism of organism, improves the feed conversion rate and the anti-stress capability, stimulates the immune function, reduces the occurrence of diseases, and has remarkable economic and social benefits as well as broad market prospect.

Description

High efficiency nutritious replenishers of a kind of livestock and poultry and preparation method thereof
Technical field
The present invention relates to a kind of feed addictive, specifically, relate to a kind of high efficiency nutritious replenishers that can replenish animal and fowl fodder subalimentation and raising immunologic function of livestock and birds and preparation method thereof.
Background technology
Along with developing rapidly of intensification high-density rearing mode, the modern varieties breeding technique is when greatly improving livestock and poultry production performance, and livestock and poultry face that wean, commentaries on classics group, vaccine inoculation, heat stress, high yield etc. are many-sided stress.Under stress situation, livestock and poultry show as feed intake and reduce, and decomposition metabolism such as body protein, carbohydrate, fat strengthen, and anabolism reduces, and causes production performance to descend; The livestock and poultry body is because of a large amount of secretions of glucocorticoid, and immune level descends; Secretions such as follicle-stimulating hormone (FSH) (FSH), metakentrin (LH) are reduced, and the livestock and poultry reproductive performance descends, miscarriage, fetal anomaly or stillborn foetus, livestock and poultry body generation physiology pathology, deterioration in quality.Common irritability pork sex change in the production, egg product matter reduce, and show as PSE, DFD meat and egg size alleviates, egg content is thin, eggshell thinning, rate of broken eggs rise, eggshell fades and soft egg rate increase etc.
At above stress, reasonably nutritional supplementation can reduce and stress endanger from root.Discharge cortisone at the stressed condition lower body and can increase demand VC, VA, VE; Stress need a large amount of stimulations of mobilizing energy to tackle stressor by the situation lower body,, therefore need to increase the nutrition of B family vitamin because the B family vitamin is the coenzyme of biochemical metabolism; The interpolation of folic acid, VA, VE, VC has promoted the reproductive performance of livestock and poultry, and having reduced stress be to the influence of reproductive performance.Stress cause deterioration in quality in addition, poultry VD under the stress situation 3Obstacle appears in absorption, eggshell thinning, and albumen is thinning, and bone growth is bad, and embryonic development is stagnated.The hypovitaminosis symptom be difficult to judge, and the loss that symptom is brought when occurring is difficult to remedy, and adds vitaminization and lags behind, and is therefore particularly important in the timely replenishing vitamins nutrition of livestock and poultry particular time.
Under stress situation, reduce dietary protein content, raising amino acid levels and adjusting acid-base balance and can reduce and to endanger.The needs of protein, be actually amino acid whose needs, China's animal protein resource is in great shortage, imported fish meal can not satisfy the demand of aquaculture far away, and price constantly rises, and aquaculture cost increases, and cultures the now consumptions that adopt domestic fish meal to substitute imported fish meal of industry more, though crude protein can reach forage standard, often cause the deficiency of amino acid whose quality and quantity.The raiser who has is on the basis, the methionine and the lysine that are aided with import again, because the nutrition concertedness of single amino acid is poor, amino acid imbalance, reduce other and must amino acid whose utilization rate cause waste, therefore replenish amino acid comprehensively, keep amino acid whose whole machine balancing and can improve livestock and poultry production performance.
The immunopotentiator sanguinarine has antibiotic, anti-trypanosome, antitumor as a kind of Bian Ji isoquinoline alkaloid, improves many-sided pharmacological actions such as liver function.Clinically, also bringing into play enormous function at aspects such as treatment tumour, skin diseases.Be used for aquatic livestock in the herding industry as pest-resistant medicine, but it is also bright in both at home and abroad reporting that sanguinarine is used to improve the immunologic function of livestock and birds aspect, the present invention filters out best sanguinarine addition through a large amount of animal experiments, has improved animal immunizing power and anti-stress ability significantly.
For anti-stress ability and the immunity that improves body, can resist by feed and drinking-water usually stress additive.Though it is many to study the interpolation effect of single Antistress agent owing to stress be many-sided to the influence of animal, single anti-stress the additive effect limited, can not be fully or farthest eliminate or alleviate stress.Therefore, stress influence at difference, studying comprehensive nutrition Antistress agent can alleviate and stress endanger from root, and exploitation tailored version anti-stress nutrition replenishers are research directions from now on.Make in the process of water-soluble products at products such as vitamin, amino acid and alkaloids, be faced with many difficult problems.Vitamin A, D, E, K are liposoluble vitamins, and be water insoluble.Amino acid forms easily floccule in the aqueous solution, also have some feed addictives to be not easy to drink water, and stops up drinking-water system easily after being prepared into water-soluble products.Have the few element of some additions to be difficult to mix, mixture homogeneity becomes an important indicator weighing the product quality quality.On the other hand, have between some vitamins to have incompatibility, in the process of configuration feed, should prevent as far as possible that the raw material of incompatibility is placed directly in together.For example calcium pantothenate very easily absorbs water, and is stable in PH is the 5-7 scope, but the deamination inactivation that very easily absorbs water in sour environment is tired and sharply glided.And nicotinic acid is acid strong, and VC acidity is also strong, certainly will increase the decomposition of calcium pantothenate.Therefore, research mixture homogeneity and water-soluble good, the stable comprehensive nutrition Antistress agent of tiring become research direction from now on.
Summary of the invention
The purpose of this invention is to provide the high efficiency nutritious replenishers of a kind of livestock and poultry, can replenish each livestock and poultry comprehensively in stage, improve the immunity and the anti-stress ability of body comprehensively at the nutritional need of particular time.
Another object of the present invention provides the preparation method of the high efficiency nutritious replenishers of a kind of livestock and poultry, and it adopts multistage premixed technology, has guaranteed the high mixture homogeneity of ultramicro-element; And processed to alkaloid employing cyclodextrin bag, guaranteed good water-solubility.
In order to realize the object of the invention, a kind of high efficiency nutritious replenishers of the present invention, it comprises the active ingredient of following weight portion: vitamin A 20-40 part, vitamin D 2-10 part, vitamin e1 0-40 part, vitamin K 31-10 part, Cobastab 11-10 part, Cobastab 210-30 part, Cobastab 62-10 part, Cobastab 120.01-0.1 part, folic acid 0.1-1 part, niacinamide 10-40 part, calcium pantothenate 2-20 part, vitamin C 30-100 part, methionine 2-15 part, lysine 2-20 part, threonine 0.5-2 part, amino acid complex 0-40 part, electrolyte 30-100 part, compound sugar 100-500 part, sanguinarine 10-100 part, carrier 0-1000 part.
Preferably, it comprises the active ingredient of following weight parts:
Vitamin A 30-40 part, vitamin D 6-10 part, vitamin E 10-15 part, vitamin K 33-5 part, Cobastab 11-2 part, Cobastab 210-20 part, Cobastab 64-5 part, Cobastab 120.03-0.05 part, folic acid 0.2-0.5 part, niacinamide 20-30 part, calcium pantothenate 4-8 part, vitamin C 60-70 part, methionine 3-8 part, lysine 3-8 part, threonine 0.7-1 part, amino acid complex 20-40 part, electrolyte 60-90 part, compound sugar 200-300 part, sanguinarine 10-30 part, carrier 200-800 part.
Amino acid complex comprises following components in part by weight described in the high efficiency nutritious replenishers of the present invention: leucine 1-10 part: glutamic acid 1-10 part: aspartic acid 2-15 part: alanine 0.1-1 part: arginine 0.5-2 part: tyrosine 0.1-1 part: valine 0.5-1.5 part: phenylalanine 0.2-1 part: proline 0.5-1 part: serine 0.2-0.8 part.
Described electrolyte is made up of 1-10 part sodium acid carbonate, 0.5-5 part potassium sulfate, 0.5-5 part potassium chloride and 10-30 part ammonium chloride.
Described compound sugar is one or both of chitosan oligosaccharide and isomalto-oligosaccharide.
Described carrier is one or both of maltodextrin or glucose.
The high efficiency nutritious replenishers of livestock and poultry of the present invention also comprise the additive of following weight parts: emulsifying agent 10-50 part, anti-current powder 0.01-10 part is wrapped by sugared 20-70 part antioxidant 0.1-20 part, cyclodextrin 10-300 part, antistatic additive 10-100 part.
Described emulsifying agent is granular glycerine monostearate.
Described anti-current powder is silica.
Described bag, is made up of with 2: 6: 2 weight ratios arabinose, starch and sucrose by sugar.
Described antioxidant is an ethoxyquinoline.
Described cyclodextrin is HP-or sulfobutyl ether-beta-cyclodextrin, and it plays bag by the effect of sanguinarine.
Described antistatic additive is a mineral white oil.
The preparation method of the high efficiency nutritious replenishers of the present invention, it comprises the steps:
1) the water-soluble processing of liposoluble vitamin: mix with water earlier by antioxidant, the emulsifying agent of said ratio with vitamin A, vitamin D, vitamin E, vitamin K1/5-1/10 amount, stir colostric fluid; It is soluble in water by sugar to get bag then, and gelatinization handled 8-12 minute, makes encrusting substance matter complex liquid; Complex liquid is added in the colostric fluid, add while stirring, stirred 5-10 minute, adjust pH 7-8, and carry out homogeneous and handle, get emulsifying liquid, carry out drying at last and handle.
2) sanguinarine is mixed with cyclodextrin, ethanol, heating is back to sanguinarine and dissolves fully, flings to ethanol, obtains water-soluble inclusion compound.
3) adopt multistage premix to handle:
With the antioxidant mixing of the carrier of methionine, lysine, threonine, amino acid complex and 1/4-1/10 amount and 1/5-1/10 amount 15-20 minute, make intermediate 1 by said ratio;
With the carrier mixing of the antistatic additive of the anti-current powder of folic acid and 1/100-1/500 amount, 1/100-1/1000 amount, 1/50-1/200 amount 15-20 minute, make intermediate 2;
With the carrier mixing of the antioxidant of the anti-current powder of calcium pantothenate and 1/10-1/50 amount, 1/10-1/50 amount, 1/10-1/30 amount 10-20 minute, make intermediate 3;
With Cobastab 1, Cobastab 12With the carrier mixing of 1/50-1/200 amount 10-20 minute, make intermediate 4;
4) at last each step and residue all the components are mixed.
In the preparation process of the present invention mixture homogeneity is controlled at below 3%, product is water-soluble, mixture homogeneity is good.
The using method of the high efficiency nutritious replenishers of the present invention can be carried out in the following manner:
A: newborn piglet: spice: 500 gram/ton mixed feeds; Drinking-water :/1000 liters of 500 grams.
B: in big pig: spice: 500 gram/ton mixed feeds; Drinking-water :/2000 liters of 500 grams.
C: boar: spice: 1000 gram/ton mixed feeds; Drinking-water :/1000 liters of 500 grams.
D: young fowl: spice: 500 gram/ton mixed feeds; Drinking-water :/1000 liters of 500 grams.
E: egg fowl: spice: 500 gram/ton mixed feeds; Drinking-water: 500 gram/1000-2000 liters.
F poultry: spice: 1000 gram/ton mixed feeds; Drinking-water :/1000 liters of 500 grams.
The present invention utilizes internal metabolism reinforcement under weaned piglet, the growing and fattening pigs stress situation, and vitamin requirement raises, and special vitamin additions such as VE, VC of strengthening having anti-oxidation function and antistress function have been strengthened the VB relevant with grice diarrhoea 1, VB 2, vitamin such as nicotinic acid and pantothenic acid addition.At content problem in the present feed, strengthen the interpolation of lysine, threonine, methionine, tryptophan, and adopted best amino acid balance principle, according to amino acid whose balanced degree in the feed, replenished other amino acid whose content at random.Do not consider the electrolyte balance index at internal feed enterprise when the formula feed, influenced livestock and poultry cylinder electrolyte and acid-base balance, the present invention introduces dietary electrolyte balance in the prescription system, to each raw material mineral (K +, Na +, Cl -Deng) carry out reasonable proportioning.
Sanguinarine can improve the immunologic function of animal, and T lymphocyte and bone-marrow-derived lymphocyte are had spread effect, is widely used in people's anticancer hepatoprotective effect.The present invention filters out best sanguinarine addition through a large amount of animal experiments, and adopts unique processed technology of cyclodextrin bag, has guaranteed that sanguinarine is not subjected to the influence of vitamin etc., and has made it water-soluble fully.
The present invention is directed to the few VB of addition 1, VB 12Carried out premixed in the few alanine of vitamin and some additions, tyrosine etc. non-limiting amino acid; The folic acid that static behaviour is very strong is handled with antistatic additive and anti-current powder; At the calcium pantothenate of incompatibility being arranged with nicotinic acid, carried out premixed in advance, avoided nicotinic acid to contact with the direct of calcium pantothenate, prevented the reduction of tiring; Mixture homogeneity that various trace elements is high and good quality stability have been guaranteed by above-mentioned multistage premixing process.
The present invention is through a large amount of animal experiments, filter out pig and use best vitamin, amino acid, electrolyte, sanguinarine, compound sugar coupling prescription at particular time, various nutritional labelings complement each other, can effectively prevent vitamin, amino acid starvation, keep electrolyte balance, regulate body metabolism, improve food conversion ratio and anti-stress ability, excite immunologic function, reduce disease and take place, have remarkable economic efficiency and social benefit, market prospects are wide.
High efficiency nutritious replenishers of the present invention have following characteristics:
1. high efficiency nutritious replenishers of the present invention are vitamin, amino acid and electrolytical gold partner, effectively prevent livestock and poultry vitamin and amino acid starvation, maintenance cylinder electrolyte balance, promote animal growth and metabolism.
2. the present invention adopts finely disseminated pulvis, and is instant fully.
3. preparation technology's uniqueness of the present invention adopts multistage premixed technology, has guaranteed the high mixture homogeneity of ultramicro-element.
4. high efficiency nutritious replenishers of the present invention can prevent or slow down the stress reaction that livestock and poultry cause factors such as scorching summer and freezing winter, vaccine inoculation, disconnected beak, commentaries on classics group, ambient weather variations; Improve human body immune function and immunity inoculation effect, when animal falls ill, cooperate drug therapy, can accelerate the sick body rehabilitation.
5. high efficiency nutritious replenishers of the present invention can improve meat livestock and poultry weightening finish, reduce feedstuff-meat ratio, improve food conversion ratio.Use at the fowl egg-laying peak, can obviously prolong egg-laying peak, improve quality of egg, color, raising egg size, reduce the quantity of breaking eggshell, soft-preserved egg, husky lime-preserved egg.
6. high efficiency nutritious replenishers of the present invention can improve rate of fertilization, incubation rate, laying rate and the farrowing rate of kind of livestock and poultry.
Description of drawings
Fig. 1 is the influence of the high efficiency nutritious replenishers of the present invention to daily gain;
Fig. 2 is the influence of the high efficiency nutritious replenishers of the present invention to feedstuff-meat ratio;
Fig. 3 is that the high efficiency nutritious replenishers of the present invention are to the influence to the diarrhoea incidence.
The specific embodiment
Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.
Embodiment 1
The high efficiency nutritious replenishers of the livestock and poultry of present embodiment comprise following component: vitamin A 30 grams, vitamin D 6 grams, vitamin E 15 grams, vitamin K 33 grams, Cobastab 11.5 gram, Cobastab 210 grams, Cobastab 64 grams, Cobastab 120.05 gram, folic acid 0.3 gram, niacinamide 20 grams, calcium pantothenate 6 grams, vitamin C 60 grams, methionine 5 grams, lysine 5 grams, threonine 0.85 gram, amino acid complex 20 grams, electrolyte 80 grams, chitosan oligosaccharide 100 grams, isomalto-oligosaccharide 100 grams, sanguinarine 15 grams, maltodextrin 318.3 grams, glucose 200 grams, glycerine monostearate 15 grams, silica 3.11 grams, ethoxyquinoline 3.11 grams, mineral white oil 20.02 grams, HP-200 grams, arabinose 8 grams, starch 24 grams, sucrose 8 grams.
Proportioning between each composition of amino acid complex is: leucine 1.8: glutamic acid 2: aspartic acid 2: alanine 1: arginine 0.9: tyrosine 0.8: valine 0.9: phenylalanine 0.9: proline 0.7: serine 0.75.
Electrolytical ratio is a sodium acid carbonate 1: potassium sulfate 1: potassium chloride 2: ammonium chloride 20.
It follows these steps to preparation:
1) with vitamin A 30 grams, vitamin D 6 grams, vitamin E 15 grams, vitamin K 33 grams, glycerine monostearate 15 grams, ethoxyquinoline 0.5 gram mix, and add in 80 ml distilled waters, make colostric fluid in agitator; Get arabinose 8 gram, starch 24 grams, sucrose 8 grams then and be dissolved in 100 ml distilled waters, and gelatinization 10 minutes, encrusting substance matter complex liquid made; Complex liquid is added in the colostric fluid, add while stirring, stirred 5 minutes, adjust pH is made emulsion 8; Emulsion is put into homogenizer, make emulsifying liquid, emulsifying liquid is put into the dry processing of compatibility drier.
2) 15 gram sanguinarine are mixed with 200 gram HP-s, 1000ml ethanolic solution, heating is back to sanguinarine and dissolves fully, flings to ethanol, obtains water-soluble inclusion compound.
3) adopt multistage premixing process:
The first step is with methionine 5 grams, and lysine 5 restrains, threonine 0.85 gram, and intermediate was made in amino acid complex 20 grams, 100 gram maltodextrins and 0.5 gram ethoxyquinoline mixing in 15 minutes.
Second step restrained maltodextrins with 0.3 gram folic acid and 0.01 gram silica, 0.05 gram mineral white oil, 5 and mixes and made intermediate in 15 minutes.
The 3rd step restrained glucose with 6 gram calcium pantothenates and 0.1 gram silica, 0.1 gram ethoxyquinoline and 40 and mixes and made intermediate in 20 minutes;
The 4th step is with vitamin 1.5 gram B 1, 0.05 the gram Cobastab 12Mix and made intermediate in 20 minutes with 20 gram glucose;
4) at last with step 1), 2), 3) with 2 gram ethoxyquinolines, 80 gram electrolyte, 3 gram silica, 20 gram mineral white oils, chitosan oligosaccharides, 100 grams, isomalto-oligosaccharide 100 grams, 213.3 gram maltodextrins, 140 gram glucose mixed 15 minutes, were prepared into 1000 gram finished products.
The high efficiency nutritious supplement application of the livestock and poultry of present embodiment in livestock and poultry occur more greatly stress, vaccine inoculation or weaned piglet phase, boar breeding period, egg-laying peak.
Embodiment 2
The high efficiency nutritious replenishers of the livestock and poultry of present embodiment comprise following component: vitamin A 20 grams, vitamin D 2 grams, vitamin E 10 grams, vitamin K 31 gram, Cobastab 11 gram, Cobastab 210 grams, Cobastab 62 grams, Cobastab 120.01 gram, folic acid 0.1 gram, niacinamide 10 grams, calcium pantothenate 2 grams, vitamin C 30 grams, methionine 2 grams, lysine 2 grams, threonine 0.5 gram, electrolyte 50 grams, chitosan oligosaccharide 50 grams, isomalto-oligosaccharide 50 grams, sanguinarine 10 grams, maltodextrin 447.39 grams, glucose 300 grams, glycerine monostearate 10 grams, silica 3.11 grams, ethoxyquinoline 3.01 grams, mineral white oil 20.04 grams, HP-160 grams, arabinose 8 grams, starch 24 grams, sucrose 8 grams.
Electrolytical ratio is a sodium acid carbonate 1: potassium sulfate 1: potassium chloride 2: ammonium chloride 20.
It follows these steps to preparation:
1) with vitamin A 20 grams, vitamin D 2 grams, vitamin E 10 grams, vitamin K 31 gram, glycerine monostearate 10 gram, ethoxyquinoline 0.5 gram mix, and add in 80 ml distilled waters, and water temperature remains in 70 ℃ the agitator and makes colostric fluid; Get arabinose 8 gram, starch 24 grams, sucrose 8 grams then and be dissolved in 100 ml distilled waters, and gelatinization 10 minutes again, encrusting substance matter complex liquid made; Complex liquid is added in the colostric fluid, add while stirring, stirred 5 minutes, adjust pH is made emulsion 8; Emulsion is put into homogenizer, make emulsifying liquid, emulsifying liquid is put into the dry processing of compatibility drier.
2) 10 gram sanguinarine are mixed with 160 gram HP-s, 1000ml ethanolic solution, heating is back to sanguinarine and dissolves fully, flings to ethanol, obtains water-soluble inclusion compound.
3) adopt multistage premixing process:
The first step is with methionine 2 grams, and lysine 2 restrains, threonine 0.5 gram, and 100 gram maltodextrins and 0.4 gram ethoxyquinoline mix made intermediate in 15 minutes.
Second step restrained maltodextrins with 0.1 gram folic acid and 0.01 gram silica, 0.04 gram mineral white oil, 5 and mixes and made intermediate in 15 minutes.
The 3rd step restrained glucose with 2 gram calcium pantothenates and 0.1 gram silica, 0.1 gram ethoxyquinoline antioxidant and 40 and mixes and made intermediate in 20 minutes;
The 4th step is with vitamin 1 gram Cobastab 1, 0.01 the gram Cobastab 12Mix and made intermediate in 20 minutes with 10 gram glucose;
4) at last with step 1), 2), 3) with 2 gram ethoxyquinolines, 50 gram electrolyte, 3 gram silica, 20 gram mineral white oils, chitosan oligosaccharides, 50 grams, isomalto-oligosaccharide 50 grams, 342.39 gram maltodextrins, 250 gram glucose mixed 15 minutes, were prepared into 1000 gram finished products.
The high efficiency nutritious replenishers of the livestock and poultry of present embodiment can be applicable to each stage of its feeding.
Embodiment 3
The high efficiency nutritious replenishers of the livestock and poultry of present embodiment comprise following component: vitamin A 40 grams, vitamin D 10 grams, vitamin E 40 grams, vitamin K 310 grams, Cobastab 15 grams, Cobastab 230 grams, Cobastab 65 grams, Cobastab 120.1 gram, folic acid 1 gram, niacinamide 40 grams, calcium pantothenate 10 grams, vitamin C 80 grams, methionine 8 grams, lysine 8 grams, threonine 1 gram, amino acid complex 40 grams, electrolyte 100 grams, chitosan oligosaccharide 100 grams, isomalto-oligosaccharide 100 grams, sanguinarine 30 grams, maltodextrin 241.9 grams, glucose 100 grams, glycerine monostearate 50 grams, silica 5.6 grams, ethoxyquinoline 3.9 grams, mineral white oil 20.2 grams, HP-200 grams, arabinose 16 grams, starch 48 grams, sucrose 16 grams.
Electrolytical ratio is a sodium acid carbonate 1: potassium sulfate 1: potassium chloride 2: ammonium chloride 20.
Amino acid complex comprises following components in part by weight: leucine 10: glutamic acid 1: aspartic acid 15: alanine 0.1: arginine 0.5: tyrosine 1: valine 0.5: phenylalanine 0.2: proline 0.5: serine 0.2.
It follows these steps to preparation:
1) with vitamin A 40 grams, VD1 0 gram, vitamin E 40 grams, vitamin K 310 grams, glycerine monostearate 50 grams, ethoxyquinoline 1 gram mix, add? in the amount distilled water, water temperature remains in 70 ℃ the agitator and makes colostric fluid; Get arabinose 16 gram, starch 48 grams, sucrose 16 grams then and be dissolved in 250 ml distilled waters, and gelatinization 10 minutes again, encrusting substance matter complex liquid made; Complex liquid is added in the colostric fluid, add while stirring, stirred 5 minutes, adjust pH is made emulsion 8; Emulsion is put into homogenizer, make emulsifying liquid, emulsifying liquid is put into the dry processing of compatibility drier.
2) 30 gram sanguinarine are mixed with 200 gram HP-s, 1000ml ethanolic solution, heating is back to sanguinarine and dissolves fully, flings to ethanol, obtains water-soluble inclusion compound.
3) adopt multistage premixing process:
The first step is with methionine 8 grams, and lysine 8 restrains, threonine 1 gram, and 60 gram maltodextrins and 0.5 gram ethoxyquinoline mix made intermediate in 15 minutes.
Second step restrained maltodextrins with 1 gram folic acid and 0.1 gram silica, 0.2 gram mineral white oil, 5 and mixes and made intermediate in 15 minutes.
The 3rd step restrained glucose with 10 gram calcium pantothenates and 0.5 gram silica, 0.3 gram ethoxyquinoline and 30 and mixes and made intermediate in 20 minutes;
The 4th step is with vitamin 5 gram B 1, 0.1 the gram Cobastab 12, 30 gram glucose mix and to make intermediate in 20 minutes;
4) at last with step 1), 2), 3) mixed 15 minutes with 2 gram ethoxyquinolines, 100 gram electrolyte, 5 gram silica, 20 gram mineral white oils and 176.9 gram maltodextrins, chitosan oligosaccharides, 100 grams, isomalto-oligosaccharide 100 grams, 40 gram glucose, be prepared into 1000 and restrain finished products.
The high efficiency nutritious replenishers of the livestock and poultry of present embodiment can be applicable to during the extremely unbalanced or livestock and poultry serious disease of feed nutrition.
Embodiment 4
Preparation process is with embodiment 1, and different is that the high efficiency nutritious replenishers of the livestock and poultry of present embodiment comprise following component: vitamin A 35 grams, vitamin D 5 grams, vitamin E 30 grams, vitamin K 35 grams, Cobastab 110 grams, Cobastab 220 grams, Cobastab 610 grams, Cobastab 120.03 gram, folic acid 0.5 gram, niacinamide 30 grams, calcium pantothenate 4 grams, vitamin C 70 grams, methionine 15 grams, lysine 20 grams, threonine 2 grams, amino acid complex 30 grams, electrolyte 30 grams, chitosan oligosaccharide 200 grams, isomalto-oligosaccharide 100 grams, sanguinarine 100 grams, maltodextrin 341.9 grams, glucose 50 grams, glycerine monostearate 10 grams, silica 8.5 grams, ethoxyquinoline 10 grams, mineral white oil 40 grams, HP-300 grams, arabinose 15 grams, starch 30 grams, sucrose 20 grams.
Amino acid complex comprises following components in part by weight: leucine 1: glutamic acid 10: aspartic acid 8: alanine 0.5: arginase 12: tyrosine 0.1: valine 1.5: phenylalanine 1.0: proline 1: serine 0.8.
Test example 1
1 materials and methods
1.1 experimental design
Single-factor random experiment design is adopted in this test, if 5 processed group, promptly test 1 group, 2 groups of tests, 3 groups of tests, test 4 groups and test 5 groups, 5 test group are the embodiments of the invention 1 that add 100g, 200g, 300g, 400g and 500g per ton on the basal diet basis respectively.
1.2 experimental animal
Select 400 Ai Wei mattress meat chicks for use, be divided into 5 groups at random, establish 4 repetitions for every group, each repeats 20.
1.3 test daily ration
The test daily ration is consulted to formulate by Beijing Fuwish Biotechnology Co., Ltd and plant jointly.
1.4 feeding and management
Experimental animal is raised in cages, and the test cage is 4 ply formula breeding cages, free choice feeding and drinking-water, temperature, humidity and illumination in the control house.
1.5 testing index and method
Average daily gain: when on-test, claim to try the initial body weight of chicken, weigh weekly later on 1 time, weighed in 12 hours on an empty stomach, and do detail record, calculate the test average daily gain.
Average daily ingestion amount: add up the test chicken feed consumption rate weekly 1 time, clout reclaims, and calculates average daily ingestion amount.
Material anharmonic ratio: average daily ingestion amount/average daily gain.
Get 8 at random and butcher after weighing for every group after the off-test, separate duodenum, barnyard and ileum, measure the length and the weight of each section of enteron aisle respectively, and unit of account is heavy and the organ index.Heavy (the g)/length (cm) of unit weight (g/cm)=intestines, heavy (the g)/live-weight (g) of organ index (%)=organ.
1.6 data are handled
Data statistics adopts the ANOVA program among the SAS8.2 to carry out statistical analysis, uses Duncan ' s method to carry out multiple ratio.The result represents with " average ± standard deviation ".
2 results and analysis
2.1 the present invention is to the influence of meat chick production performance
The influence of table 1 pair meat chick production performance
The mensuration project Test 1 group Test 2 groups Test 3 groups Test 4 groups Test 5 groups
Average daily gain (g) ??53.38±2.14 ??53.32±2.09 ??53.46±2.35 ??53.35±1.35 ??53.42±2.63
Average daily ingestion amount (g) ??140.66±3.24 ??140.23±2.47 ??139.53±2.56 ??138.71±2.68 ??138.89±2.63
Material anharmonic ratio (F/G) ??2.64±0.84 ??2.63±0.23 ??2.61±0.86 ??2.60±0.56 ??2.60±1.22
As can be seen from Table 1, along with the increase material anharmonic ratio reduction of the present invention's addition in daily ration, test 5 groups than 1 group low 1.52% of test.
2.2 the present invention is to the influence of meat chick intestinal growth
The table 2 pair influence that meat chick duodenum grows
The mensuration project Length Weight Unit weight The organ index
Test
1 group ??23.13±1.47 ??6.61±0.44 ??0.28±0.02 ??0.37±0.01
Test 2 groups ??24.67±2.40 ??7.59±0.03 ??0.30±0.01 ??0.43±0.02
Test 3 groups ??25.28±1.52 ??7.94±0.62 ??0.31±0.02 ??0.43±0.01
Test 4 groups ??26.50±2.13 ??8.31±0.19 ??0.31±0.01 ??0.44±0.02
Test 5 groups ??26.70±2.07 ??8.50±0.81 ??0.31±0.02 ??0.44±0.01
The table 3 pair influence that meat chick jejunum grows
The mensuration project Length Weight Unit weight The organ index
Test
1 group ??49.47±2.29 ??11.68±0.40 ??0.23±0.01 ??0.67±0.03
Test 2 groups ??56.91±1.97 ??12.08±0.29 ??0.22±0.01 ??0.69±0.22
Test 3 groups ??57.37±1.15 ??12.51±0.07 ??0.22±0.01 ??0.70±0.01
Test 4 groups ??58.24±1.83 ??13.52±1.05 ??0.23±0.02 ??0.70±0.02
Test 5 groups ??59.76±4.33 ??13.78±0.96 ??0.23±0.01 ??0.71±0.03
The table 4 pair influence that meat chick ileum grows
The mensuration project Length Weight Unit weight The organ index
Test
1 group ??58.77±1.46 ??8.99±1.09 ??0.15±0.02 ??0.51±0.03
Test 2 groups ??58.47±2.14 ??9.74±1.05 ??0.17±0.01 ??0.51±0.02
Test 3 groups ??61.17±0.96 ??10.00±0.65 ??0.16±0.01 ??0.56±0.03
Test 4 groups ??61.33±1.32 ??10.39±0.51 ??0.17±0.02 ??0.56±0.02
Test 5 groups ??62.06±1.67 ??10.51±0.86 ??0.17±0.01 ??0.57±0.01
By table 2, table 3 and table 4 as can be seen, test unit weight of 2,3,4 and 5 groups of duodenums, jejunum and ileums and organ index are with the more increase of addition and in various degree increase of good fortune.
Test example 2
1 materials and methods
1.1 experimental animal and grouping
Select 60 of the close three way cross market pigs of the initial body weight of 28 ages in days, be divided into 4 processed group at random, the 4 kinds of diets of feeding respectively, 3 repetitions of each processed group, each repeats 5 pigs (male and female half and half).Test 1 group, 2 groups, 3 groups, 4 groups interpolation 0g per ton, 200g, 350g and 500g embodiments of the invention 2 on the basal diet basis.
1.2 common negotiation of basal diet Beijing Fuwish Biotechnology Co., Ltd and plant determined.
1.3 feeding and management
Feeding experiment is carried out on kind pig farm, Beijing.Each repeats test pig to raise in a hurdle.Test pig is only adopted unified management, and regularly the mode that feeds intake is raised, and day feeds 4 times, freely drinks water.Control the uniformity of feeding and management condition in phase in whole test as far as possible.Feeding period 20 days.
1.4 testing index and method
When on-test and end, the examination pig claims individual weight in 2d behind the 16h on an empty stomach the morning, respectively repeats pig diet consumption during the statistical test, calculates average daily gain, feed intake, feedstuff-meat ratio.Duration of test is observed the grice diarrhoea situation at any time.
1.5 data are handled
The ANOVA program of testing among all The data SAS8.2 is carried out statistical analysis, uses Duncan ' s method to carry out multiple ratio.
2 interpretations of result and discussion
Each processed group pig growth performance basic condition of duration of test sees Table 5.
The influence of table 5 pair production performance
Project Test 1 group Test 2 groups Test 3 groups Test 4 groups
Average starting weight (kg) ??6.56±0.27 ??6.66±0.39 ??6.76±0.25 ??6.85±0.35
Average end heavy (kg) ??12.12±0.72 ??12.71±0.62 ??13.37±0.52 ??13.70±0.69
Daily gain (g) ??278.92±14.1 ??302.5±12.5 ??330.3±12.5 ??342.4±12.5
Daily ingestion amount (g) ??543.9±24.7 ??548.6±30.5 ??550.5±29.6 ??554.7±27.6
Feedstuff-meat ratio (F/G) ??1.95 ??1.81 ??1.67 ??1.62
Diarrhoea incidence (%) ??3.75 ??2.69 ??2.28 ??1.25
From table 5 and Fig. 1-3 as can be seen, daily gain is the trend of increase with the increase of addition of the present invention, test 4 groups than 1 group high by 22.76% of test, feed intake slightly increases with the increase of addition of the present invention, but feedstuff-meat ratio significantly reduces with the increase of addition of the present invention, tests 4 groups than 1 group low 16.92% of test.The diarrhoea incidence significantly reduces with the increase of the present invention's addition in diet, test 4 groups than 1 group of minimizing 66.67% of test, reason may can provide energy source efficiently for the intestinal villus cell for additive in this product, promote the growth and the reparation of intestinal villus cell, can keep the normal 26S Proteasome Structure and Function of intestinal villus, thereby significantly reduce the diarrhoea incidence, promote the increase of feed intake, and then impel piglet growth to quicken, and reduce feedstuff-meat ratio, improve production performance.
The application study of test example 3 the present invention in egg kind chicken produces
1 materials and methods
1.1 experimental animal, basal diet and feeding and management
1.1.1 experimental animal is chosen 316 ages in days, the extra large blue brown shell layer that body weight is close.
1.1.2 common negotiation of basal diet Beijing Fuwish Biotechnology Co., Ltd and plant determined.
, feeding and management test chicken feeding manner raises in cages 3 chickens of every cage 1.1.3 being staged.Fed by the special messenger, feeding and management is identical, all adopts hand fed, free choice feeding and drinking-water, and artificial insemination, every day, light application time was 16 hours, intensity of illumination is 10 Luxs.Write down feed consumption rate, egg number, kind egg qualification rate, extremely naughty chicken number every day, the state of mind of observing chicken, drinking-water situation, fecal nature.Since the 15th day of experimental period, per 3 days was a collection of, selected the mensuration that qualified kind egg carries out rate of fertilization, incubation rate, strong young rate for every group continuous 6 batches.30 eggs of every group of extraction are at random surveyed egg size, shell thickness, Ha Shi unit when experimental period finishes.
1.2 experimental design
1.2.1 select 720 of the healthy extra large blue brown shell layers of 31 ages in days for use, be divided into control group and test group at random, each is handled and divides 6 repetitions, and each repeats 60.The phase of raising is 3 days in advance, two groups of basal diets of all feeding.The phase of raising in advance, every index difference of test group and control group observation was all not remarkable when finishing.33 days experimental periods, control group fed basal diet, the test group interpolation 500g embodiments of the invention 3 per ton of feeding.
1.2.2 test site and time test are carried out at Beijing kind chicken house; Test period from August 24 to September 21.
1.3 testing index and method
1.3.1 performance test
Average every feed consumption rate every day (g)=every day feed consumption rate/raising chicken number
Death rate (%)=is extremely washed in a pan chicken number/raising chicken and is counted * 100%
Average egg weight
Plant egg qualification rate (%)
1.3.2 egg product matter index determining
Shell thickness (mm) is measured blunt end, middle part, the sharp end of egg respectively and is averaged after getting shell thickness.
Ha Shi unit=100Log (H-1.7W 0.37+ 7.57) H-is dense albumen height, with milli
Rice is unit; W-is an egg size, is unit with the gram.
The minor axis of the major diameter/egg of egg shape index=egg
1.3.3 reproductive performance is measured
Rate of fertilization (%)=fertile egg number/go into incubation to count * 100%
Incubation rate (%)=chickling-surviving number/fertile egg is counted * 100%
Strong young rate (%)=strong young rate/several * 100% of emerging
1.4 data statistics and processing
Test all data and use the t check to carry out significance of difference analysis, data are represented with mean+SD.
2 results and analysis
2.1 influence to egg kind chicken production performance
The influence of table 6 pair egg kind chicken production performance
Project Control group Test group
Laying rate, % ??71.86±2.97 ??75.57±2.17
Death rate, % ??2.46±0.14 ??0.63±0.21
Average egg weight, g ??60.65±4.93 ??63.33±3.82
Average egg qualification rate, the % of planting ??92.44±1.53 ??95.72±1.96
Average daily ingestion amount, g ??101.76±8.42 ??109.27±7.83
By table 6 as seen, adding behind the present invention laying rate, average egg weight in the egg kind daily grain of chicken and on average planting the egg qualification rate increases, the test group laying rate is higher by 5.16% than control group, and the average egg weight test group increases by 4.42% than control group, and it is higher by 3.55% than control group on average to plant egg qualification rate test group.Death rate reduces after adding the present invention in the daily ration, and test group is than control group low 74.39%.
2.2 influence to egg product matter
The influence of table 7 pair egg product matter
Project Control group Test group
Shell thickness, mm ??0.338±0.027 ??0.359±0.036
Ha Shi unit ??80.36±5.26 ??85.73±5.12
The egg shape index ??1.302±2.24 ??1.308±3.28
As can be seen from Table 7, add in the diet that shell thickness and Ha Shi unit all increase behind the present invention, good shell thickness is generally about 0.33～0.35mm, shell thickness is when 0.25mm is following, can produce about 85% check, shell thickness is big more, and the fresh-keeping degree of egg is just high more, and the nutritive peculiarity holding time of egg is long more for a long time.Ha Shi unit is a freshness of weighing protein quality and egg, and the Hardgrove index of fresh-laid egg is more than 80, and dense albumen is high more, and egg is just fresh more, and Ha Shi unit is just big more, and Ha Shi unit is closely related with incubation rate.
2.3 influence to egg kind chicken reproductive performance
The influence of table 8 pair egg kind chicken reproductive performance
Project Control group Test group
Rate of fertilization, % ??93.78±2.75 ??95.66±1.36
Incubation rate, % ??82.37±4.31 ??86.99±1.64
Strong young rate, % ??88.32±3.47 ??93.79±1.36
As can be seen from Table 8, behind interpolation the present invention, rate of fertilization, incubation rate and strong young rate all improve in the diet, and the rate of fertilization test group is higher by 2.00% than control group, and the incubation rate test group is higher by 5.61% than control group, and strong young rate test group is higher by 6.19% than control group.
Though above the present invention is described in detail with a general description of the specific embodiments, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements all belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.

Claims (9)

1. the high efficiency nutritious replenishers of livestock and poultry is characterized in that it comprises the active ingredient of following weight portion: dehydroretinol 0-40 part, vitamin D 2-10 part, vitamin E 10-40 part, vitamin K 31-10 part, Cobastab 11-10 part, Cobastab 210-30 part, Cobastab 62-10 part, Cobastab 120.01-0.1 part, folic acid 0.1-1 part, niacinamide 10-40 part, calcium pantothenate 2-20 part, vitamin C 30-100 part, methionine 2-15 part, lysine 2-20 part, threonine 0.5-2 part, amino acid complex 0-40 part, electrolyte 30-100 part, compound sugar 100-500 part, sanguinarine 10-100 part, carrier 0-1000 part.
2. the high efficiency nutritious replenishers of livestock and poultry according to claim 1 is characterized in that it comprises the active ingredient of following weight parts:
Vitamin A 30-40 part, vitamin D 6-10 part, vitamin E 10-15 part, vitamin K 33-5 part, Cobastab 11-2 part, Cobastab 210-20 part, Cobastab 64-5 part, Cobastab 120.03-0.05 part, folic acid 0.2-0.5 part, niacinamide 20-30 part, calcium pantothenate 4-8 part, vitamin C 60-70 part, methionine 3-8 part, lysine 3-8 part, threonine 0.7-1 part, amino acid complex 20-40 part, electrolyte 60-90 part, compound sugar 200-300 part, sanguinarine 10-30 part, carrier 200-800 part.
3. the high efficiency nutritious replenishers of livestock and poultry according to claim 1 and 2, it is characterized in that described amino acid complex comprises following components in part by weight: leucine 1-10 part: glutamic acid 1-10 part: aspartic acid 2-15 part: alanine 0.1-1 part: arginine 0.5-2 part: tyrosine 0.1-1 part: valine 0.5-1.5 part: phenylalanine 0.2-1 part: proline 0.5-1 part: serine 0.2-0.8 part.
4. the high efficiency nutritious replenishers of livestock and poultry according to claim 1 and 2 is characterized in that, described electrolyte is made up of 1-10 part sodium acid carbonate, 0.5-5 part potassium sulfate, 0.5-5 part potassium chloride and 10-30 part ammonium chloride.
5. the high efficiency nutritious replenishers of livestock and poultry according to claim 1 and 2 is characterized in that described compound sugar is one or both of chitosan oligosaccharide and isomalto-oligosaccharide.
6. the high efficiency nutritious replenishers of livestock and poultry according to claim 1 and 2 is characterized in that described carrier is one or both of maltodextrin or glucose.
7. according to any high efficiency nutritious replenishers of described livestock and poultry of claim 1-6, it is characterized in that, the additive that also comprises following weight parts: emulsifying agent 10-50 part, anti-current powder 0.01-10 part, bag is by sugared 20-70 part, antioxidant 0.1-20 part, cyclodextrin 10-300 part, antistatic additive 10-100 part.
8. the high efficiency nutritious replenishers of livestock and poultry according to claim 7 is characterized in that, described emulsifying agent is granular glycerine monostearate; Described anti-current powder is silica; Described bag, is made up of with 2: 6: 2 weight ratios arabinose, starch and sucrose by sugar; Described antioxidant is an ethoxyquinoline; Described cyclodextrin is HP-or sulfobutyl ether-beta-cyclodextrin; Described antistatic additive is a mineral white oil.
9. prepare the method for any high efficiency nutritious replenishers of described livestock and poultry of claim 1-8, it is characterized in that it comprises the steps:
1) the water-soluble processing of liposoluble vitamin: mix with distilled water earlier by antioxidant, the emulsifying agent of said ratio with vitamin A, vitamin D, vitamin E, vitamin K, 1/5-1/10 amount, stir colostric fluid; It is soluble in water by sugar to get bag then, and gelatinization handled 8-12 minute, makes encrusting substance matter complex liquid; Complex liquid is added in the colostric fluid, add while stirring, stirred 5-10 minute, adjust pH 7-8, and carry out homogeneous and handle, get emulsifying liquid, carry out drying at last and handle;
2) sanguinarine is mixed with cyclodextrin, ethanol, heating is back to sanguinarine and dissolves fully, flings to ethanol, obtains water-soluble inclusion compound;
3) adopt multistage premix to handle:
With the antioxidant mixing of the carrier of methionine, lysine, threonine, amino acid complex and 1/4-1/10 amount and 1/5-1/10 amount 15-20 minute, make intermediate 1 by said ratio;
With the carrier mixing of the antistatic additive of the anti-current powder of folic acid and 1/100-1/500 amount, 1/100-1/1000 amount, 1/50-1/200 amount 15-20 minute, make intermediate 2;
With the carrier mixing of the antioxidant of the anti-current powder of calcium pantothenate and 1/10-1/50 amount, 1/10-1/50 amount, 1/10-1/30 amount 10-20 minute, make intermediate 3;
With Cobastab 1, Cobastab 12With the carrier mixing of 1/50-1/200 amount 10-20 minute, make intermediate 4;
4) at last each step and residue all the components are mixed.
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CN106962616A (en) * 2017-04-11 2017-07-21 南京佳果生物科技有限公司 A kind of Animal nutrition agent and preparation method thereof
CN107027976A (en) * 2017-06-19 2017-08-11 佛山市南海东方澳龙制药有限公司 Poultry Water Soluble Compound nutritious supplementary pharmaceutical and preparation method thereof
CN107397074A (en) * 2017-08-25 2017-11-28 鞍山兴达伟业矿物质科技有限公司 Improve the microelement pre-mix material for later stage eggshell quality of laying eggs
CN107683974A (en) * 2017-09-01 2018-02-13 武汉轻工大学 A kind of health beverage concentrate for promoting chick growth and preparation method thereof
CN107683974B (en) * 2017-09-01 2021-05-28 武汉轻工大学 Health care concentrated beverage for promoting growth of chicks and preparation method thereof
CN109123100A (en) * 2018-08-27 2019-01-04 佛山市正典生物技术有限公司 A kind of microcapsule feedstuff additive and preparation method thereof and animal and fowl fodder
CN108967735A (en) * 2018-10-11 2018-12-11 河北正合生物制药有限公司 A kind of feed addictive that can improve chicken intestinal institutional framework and growth performance
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CN115176755A (en) * 2022-06-09 2022-10-14 云南海大生物科技有限公司 Feeding method of Luchuan pigs

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