CN109745557A - A kind of veterinary vaccine adjuvant and preparation method thereof and application method - Google Patents
A kind of veterinary vaccine adjuvant and preparation method thereof and application method Download PDFInfo
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- CN109745557A CN109745557A CN201910183042.6A CN201910183042A CN109745557A CN 109745557 A CN109745557 A CN 109745557A CN 201910183042 A CN201910183042 A CN 201910183042A CN 109745557 A CN109745557 A CN 109745557A
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- vitamin
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- rhizoma atractylodis
- atractylodis macrocephalae
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Abstract
The present invention relates to a kind of livestock and poultry pharmaceutical auxiliaries, more particularly to a kind of veterinary vaccine adjuvant, raw material components including following volume fraction: Radix Astragali extractive solution 15-30%, acanthopanax senticosus extract 10-20%, windproof extracting solution 5-10%, Rhizoma Atractylodis Macrocephalae extracting solution 5-10%, vitamin B1 >=0.05%, vitamin B6 >=0.1%, vitamin C >=0.3%, niacinamide >=0.8%；Surplus is antioxidant and pure water.The method can significantly improve IFN-γ levels, increase the expression of Macrophage Surface histocompatibility complex (MHC) II class molecule, enhance its antigen submission ability, macrophage phagocytic immunity is promoted to meet ability, significantly improve total IgG antibody level, activating complement classical pathway mediates bacteriolyze and cytotoxicity, neutralizes a toxin and viral；The proliferation for improving the lymphocyte of livestock and poultry, to enhance immune response, it is ensured that veterinary vaccines immune effect.
Description
Technical field
The present invention relates to a kind of livestock and poultry pharmaceutical auxiliaries more particularly to a kind of veterinary vaccine adjuvant and preparation method thereof and
Application method.
Background technique
Livestock and poultry are before and after vaccine inoculation, if its body cannot improve the immune response level that specific antigen stimulates
If, immune effect of vaccine will be very poor, or even therefore the antiviral functions and immune function that will affect livestock and poultry itself need
It to be used using special vaccine adjuvant cooperation vaccine.
Summary of the invention
For the present invention in order to solve above-mentioned defect existing in the prior art and deficiency, providing a kind of can significantly improve IFN-
γ is horizontal, increases the expression of Macrophage Surface histocompatibility complex (MHC) II class molecule, enhances its antigen submission ability,
Macrophage phagocytic immunity is promoted to meet ability, hence it is evident that improve total IgG antibody level, activating complement classical pathway mediates bacteriolyze
And cytotoxicity, it neutralizes a toxin and viral；The proliferation for improving the lymphocyte of livestock and poultry, to enhance immune response, really
Protect veterinary vaccine adjuvant of veterinary vaccines immune effect and preparation method thereof and application method.
Technical solution of the present invention: a kind of veterinary vaccine adjuvant, the raw material components including following volume fraction:
Radix Astragali extractive solution 15-30%,
Acanthopanax senticosus extract 10-20%,
Windproof extracting solution 5-10%,
Rhizoma Atractylodis Macrocephalae extracting solution 5-10%,
Vitamin B1 >=0.05%
Vitamin B6 >=0.1%
Vitamin C >=0.3%
Niacinamide >=0.8%；
Surplus is antioxidant and pure water.
The method can significantly improve IFN-γ levels, make Macrophage Surface histocompatibility complex (MHC) II class molecule
Expression increases, and enhances its antigen submission ability, and macrophage phagocytic immunity is promoted to meet ability, hence it is evident that improves total IgG antibody water
Flat, activating complement classical pathway mediates bacteriolyze and cytotoxicity, neutralizes a toxin and viral；Improve the lymphocyte of livestock and poultry
Proliferation, to enhance immune response, it is ensured that veterinary vaccines immune effect.
A kind of veterinary vaccine adjuvant, the raw material components including following volume fraction:
Radix Astragali extractive solution 20%,
Acanthopanax senticosus extract 15%,
Windproof extracting solution 7.5%,
Rhizoma Atractylodis Macrocephalae extracting solution 7.5%,
Vitamin B1 >=0.05%
Vitamin B6 >=0.1%
Vitamin C >=0.3%
Niacinamide >=0.8%；
Surplus is antioxidant and pure water.
A kind of veterinary vaccine adjuvant, the raw material components including following volume fraction:
Radix Astragali extractive solution 30%,
Acanthopanax senticosus extract 10%,
Windproof extracting solution 10%,
Rhizoma Atractylodis Macrocephalae extracting solution 5%,
Vitamin B1 >=0.05%
Vitamin B6 >=0.1%
Vitamin C >=0.3%
Niacinamide >=0.8%；
Surplus is antioxidant and pure water.
A kind of veterinary vaccine adjuvant, the raw material components including following volume fraction:
Radix Astragali extractive solution 10%,
Acanthopanax senticosus extract 20%,
Windproof extracting solution 5%,
Rhizoma Atractylodis Macrocephalae extracting solution 10%,
Vitamin B1 >=0.05%
Vitamin B6 >=0.1%
Vitamin C >=0.3%
Niacinamide >=0.8%；
Surplus is antioxidant and pure water.
A kind of production method of veterinary vaccine adjuvant, includes the following steps:
1) pure water steam heating extraction is added in Radix Astragali, wilsonii, radix saposhnikoviae and Rhizoma Atractylodis Macrocephalae according to the ratio；
2) filter out effective component it is cooling after Radix Astragali extractive solution, acanthopanax senticosus extract, windproof extracting solution and Rhizoma Atractylodis Macrocephalae extracting solution are mixed
Close liquid；
3) vitamin B1, vitamin B6, niacinamide, vitamin C and antioxidant are added in the mixed liquor and are uniformly mixed
To final products；
4) it finally carries out canned.
Preferably, the percent by volume of each extracting solution is as follows in final products obtained in the step 3): astragalus extraction
Liquid 20%, acanthopanax senticosus extract 15%, windproof extracting solution 7.5%, Rhizoma Atractylodis Macrocephalae extracting solution 7.5%.
Preferably, quality-volumetric concentration of each vitamin is as follows in final products obtained in the step 3): vitamin
B1 >=500mg/L, vitamin B6 >=1000mg/L, niacinamide >=8000mg/L, vitamin C >=3000mg/L.
Mixed drink: a kind of application method of veterinary vaccine adjuvant is taken, is continuously taken 7-10 days, often for 3 days before fowl poultry immune
The 1000ml vaccine adjuvant is added in 1000L water.
The method can significantly improve IFN-γ levels, make Macrophage Surface histocompatibility complex (MHC) II class molecule
Expression increases, and enhances its antigen submission ability, and macrophage phagocytic immunity is promoted to meet ability, hence it is evident that improves total IgG antibody water
Flat, activating complement classical pathway mediates bacteriolyze and cytotoxicity, neutralizes a toxin and viral；Improve the lymphocyte of livestock and poultry
Proliferation, to enhance immune response, it is ensured that veterinary vaccines immune effect.
Specific embodiment
The present invention will be further described in detail below with reference to specific embodiments, but is not to the scope of the present invention
Limitation.
Embodiment 1
A kind of veterinary vaccine adjuvant, the raw material components including following volume fraction:
Radix Astragali extractive solution 20%,
Acanthopanax senticosus extract 15%,
Windproof extracting solution 7.5%,
Rhizoma Atractylodis Macrocephalae extracting solution 7.5%,
Vitamin B1 >=0.05%
Vitamin B6 >=0.1%
Vitamin C >=0.3%
Niacinamide >=0.8%；
Surplus is antioxidant and pure water.
Embodiment 2
A kind of veterinary vaccine adjuvant, the raw material components including following volume fraction:
Radix Astragali extractive solution 30%,
Acanthopanax senticosus extract 10%,
Windproof extracting solution 10%,
Rhizoma Atractylodis Macrocephalae extracting solution 5%,
Vitamin B1 >=0.05%
Vitamin B6 >=0.1%
Vitamin C >=0.3%
Niacinamide >=0.8%；
Surplus is antioxidant and pure water.
Embodiment 3
A kind of veterinary vaccine adjuvant, the raw material components including following volume fraction:
Radix Astragali extractive solution 10%,
Acanthopanax senticosus extract 20%,
Windproof extracting solution 5%,
Rhizoma Atractylodis Macrocephalae extracting solution 10%,
Vitamin B1 >=0.05%
Vitamin B6 >=0.1%
Vitamin C >=0.3%
Niacinamide >=0.8%；
Surplus is antioxidant and pure water.
A kind of production method of veterinary vaccine adjuvant, includes the following steps:
1) pure water steam heating extraction is added in Radix Astragali, wilsonii, radix saposhnikoviae and Rhizoma Atractylodis Macrocephalae according to the ratio；
2) filter out effective component it is cooling after Radix Astragali extractive solution, acanthopanax senticosus extract, windproof extracting solution and Rhizoma Atractylodis Macrocephalae extracting solution are mixed
Close liquid；
3) vitamin B1, vitamin B6, niacinamide, vitamin C and antioxidant are added in the mixed liquor and are uniformly mixed
To final products；
4) it finally carries out canned.
The percent by volume of each extracting solution is as follows in final products obtained in step 3): Radix Astragali extractive solution 20%, wilsonii
Extracting solution 15%, windproof extracting solution 7.5%, Rhizoma Atractylodis Macrocephalae extracting solution 7.5%.
Quality-volumetric concentration of each vitamin is as follows in final products obtained in step 3): vitamin B1 >=500mg/
L, vitamin B6 >=1000mg/L, niacinamide >=8000mg/L, vitamin C >=3000mg/L.
Mixed drink: a kind of application method of veterinary vaccine adjuvant is taken, is continuously taken 7-10 days, often for 3 days before fowl poultry immune
The 1000ml vaccine adjuvant is added in 1000L water.
The present invention has oral adjuvant effect to vaccine immunity, can enhance the immune effect of vaccine, the mechanism of action is logical
After feeding vaccine adjuvant of the invention in advance, stimulation body produces nonspecific immune response, then when carrying out vaccine immunity,
It is horizontal that the immune response that body stimulates specific antigen can be enhanced.
The content of antioxidant in the present invention meets the critical field of oxidation preventive content in conventional vaccine adjuvant.
The present invention in use, it should be noted that item it is as follows:
It please don't be diluted with hot water when 1. using；
2. belonging to normal phenomenon if any a small amount of precipitating not affect the treatment.
Claims (8)
1. a kind of veterinary vaccine adjuvant, it is characterised in that: it includes the raw material components of following volume fraction:
Radix Astragali extractive solution 15-30%,
Acanthopanax senticosus extract 10-20%,
Windproof extracting solution 5-10%,
Rhizoma Atractylodis Macrocephalae extracting solution 5-10%,
Vitamin B1 >=0.05%
Vitamin B6 >=0.1%
Vitamin C >=0.3%
Niacinamide >=0.8%；
Surplus is antioxidant and pure water.
2. a kind of veterinary vaccine adjuvant according to claim 1, it is characterised in that: it includes the raw material of following volume fraction
Component:
Radix Astragali extractive solution 20%,
Acanthopanax senticosus extract 15%,
Windproof extracting solution 7.5%,
Rhizoma Atractylodis Macrocephalae extracting solution 7.5%,
Vitamin B1 >=0.05%
Vitamin B6 >=0.1%
Vitamin C >=0.3%
Niacinamide >=0.8%；
Surplus is antioxidant and pure water.
3. a kind of veterinary vaccine adjuvant according to claim 1, it is characterised in that: it includes the raw material of following volume fraction
Component:
Radix Astragali extractive solution 30%,
Acanthopanax senticosus extract 10%,
Windproof extracting solution 10%,
Rhizoma Atractylodis Macrocephalae extracting solution 5%,
Vitamin B1 >=0.05%
Vitamin B6 >=0.1%
Vitamin C >=0.3%
Niacinamide >=0.8%；
Surplus is antioxidant and pure water.
4. a kind of veterinary vaccine adjuvant according to claim 1, it is characterised in that: it includes the raw material of following volume fraction
Component:
Radix Astragali extractive solution 10%,
Acanthopanax senticosus extract 20%,
Windproof extracting solution 5%,
Rhizoma Atractylodis Macrocephalae extracting solution 10%,
Vitamin B1 >=0.05%
Vitamin B6 >=0.1%
Vitamin C >=0.3%
Niacinamide >=0.8%；
Surplus is antioxidant and pure water.
5. a kind of production method of veterinary vaccine adjuvant as described in claim 1, it is characterised in that: it includes the following steps:
1) pure water steam heating extraction is added in Radix Astragali, wilsonii, radix saposhnikoviae and Rhizoma Atractylodis Macrocephalae according to the ratio；
2) filter out effective component it is cooling after Radix Astragali extractive solution, acanthopanax senticosus extract, windproof extracting solution and Rhizoma Atractylodis Macrocephalae extracting solution are mixed
Close liquid；
3) vitamin B1, vitamin B6, niacinamide, vitamin C and antioxidant are added in the mixed liquor and are uniformly mixed
To final products；
4) it finally carries out canned.
6. the production method of veterinary vaccine adjuvant according to claim 5, it is characterised in that: obtained in the step 3)
The percent by volume of each extracting solution is as follows in final products: Radix Astragali extractive solution 20%, acanthopanax senticosus extract 15%, windproof extracting solution
7.5%, Rhizoma Atractylodis Macrocephalae extracting solution 7.5%.
7. the application method of veterinary vaccine adjuvant according to claim 5, it is characterised in that: obtained in the step 3)
Quality-volumetric concentration of each vitamin is as follows in final products: vitamin B1 >=500mg/L, vitamin B6 >=1000mg/L, cigarette
Amide >=8000mg/L, vitamin C >=3000mg/L.
8. a kind of application method of veterinary vaccine adjuvant as described in claim 1, it is characterised in that: mixed drink: in fowl poultry immune
It takes within first 3 days, continuously takes 7-10 days, the 1000ml vaccine adjuvant is added in every 1000L water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201910183042.6A CN109745557A (en) | 2019-03-12 | 2019-03-12 | A kind of veterinary vaccine adjuvant and preparation method thereof and application method |
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| CN201910183042.6A CN109745557A (en) | 2019-03-12 | 2019-03-12 | A kind of veterinary vaccine adjuvant and preparation method thereof and application method |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101669578A (en) * | 2009-09-24 | 2010-03-17 | 北京福乐维生物技术有限公司 | High efficiency livestock and poultry nutrition replenisher and preparation method thereof |
| CN103860656A (en) * | 2012-12-11 | 2014-06-18 | 洛阳惠中兽药有限公司 | Traditional Chinese medicinal composition, and preparation method and application thereof |
| CN108379577A (en) * | 2018-04-08 | 2018-08-10 | 江西牧威利元生物科技有限公司 | A kind of immunopotentiator of enhancing PEDV vaccine immune responses |
-
2019
- 2019-03-12 CN CN201910183042.6A patent/CN109745557A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101669578A (en) * | 2009-09-24 | 2010-03-17 | 北京福乐维生物技术有限公司 | High efficiency livestock and poultry nutrition replenisher and preparation method thereof |
| CN103860656A (en) * | 2012-12-11 | 2014-06-18 | 洛阳惠中兽药有限公司 | Traditional Chinese medicinal composition, and preparation method and application thereof |
| CN108379577A (en) * | 2018-04-08 | 2018-08-10 | 江西牧威利元生物科技有限公司 | A kind of immunopotentiator of enhancing PEDV vaccine immune responses |
Non-Patent Citations (1)
| Title |
|---|
| 丁安伟等: "《中药资源综合利用与产品开发》", 30 April 2013, 中国中医药出版社 * |
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Application publication date: 20190514 |