CN104940371A - Chinese herbal medicine immunopotentiator for groupers - Google Patents
Chinese herbal medicine immunopotentiator for groupers Download PDFInfo
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- CN104940371A CN104940371A CN201510453933.0A CN201510453933A CN104940371A CN 104940371 A CN104940371 A CN 104940371A CN 201510453933 A CN201510453933 A CN 201510453933A CN 104940371 A CN104940371 A CN 104940371A
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- cortex phellodendri
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Abstract
The invention provides a Chinese herbal medicine immunopotentiator for groupers. The Chinese herbal medicine immunopotentiator comprises the following components in parts by weight: 20-30 parts of spatholobus stem, 15-25 parts of herba ecliptae, 10-20 parts of cortex phellodendri, 3-13 parts of coptis chinensis, 3-13 parts of fructus rubi, 3-13 parts of atractylodes macrocephala, 3-13 parts of peppermint and 3-13 parts of hemerocallis citrina baroni. The Chinese herbal medicine immunopotentiator is prepared from various green Chinese herbal medicines, small in toxic/side effect, unlikely to induct pathogenic bacteria resistance to drugs, low in pollution and price, and abundant in raw material resources; interaction of Chinese herbal medicines of spatholobus stem, herba ecliptae, cortex phellodendri, coptis chinensis, fructus rubi, atractylodes macrocephala, peppermint and hemerocallis citrina baroni which contain active ingredients is realized, so that not only is respiratory burst of leucocytes of the groupers improved, but also the leucocyte phagocytosis activity of the groupers is improved, the high average feed coefficient of the groupers is effectively reduced, the low survival rate of the groupers is increased, and the effect of immunopotentiator is excellent.
Description
Technical field
The present invention relates to field of feed additive technology, be specifically related to a kind of cabrilla Chinese medicine immunity enhancer.
Background technology
Epinephelus fin section, Epinephelus are water warm coastal waters bottom rare fish classes, its meat fertile fresh and tender, be of high nutritive value, deeply by consumers, supply falls short of demand.Because it is expensive, economic worth is high, and in recent years along with the development of culture fishery, Grouper cultivating scale goes from strength to strength, cultured output increases day by day, but the thing followed is its kinds of Diseases gets more and more, and the loss caused is also increasing.Disease and pest becomes one of key constraints of current China Grouper cultivating Sustainable Healthy Development.
Chinese herbal medicine is as green natural medicine, have that toxic and side effects is little, the many effects of multicomponent Mutiple Targets, not easily bring out the advantages such as pathogenic bacteria resistance to drugs, low stain, cheap, aboundresources, have broad application prospects in the disease control of Aquatic product non-nuisance.Though at present both at home and abroad existing a large amount of about the Chinese herbal medicine for Aquatic product diseases prevention and treatment as immunostimulant or antipathogen thing, but be all the result of use using for reference people's use or poultry Chinese medicine, and aquatic animal is from living environment or autoimmune function, and all there were significant differences with terrestrial animal, though add immunostimulant in epinephelus feed, but the mean feed between feeding period is high, survival rate is low, then the effect of immunostimulant is undesirable.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide the cabrilla Chinese medicine immunity enhancer that a kind of the mean feed is low, survival rate is high.
In order to achieve the above object, the technical scheme that the present invention takes is:
A kind of cabrilla Chinese medicine immunity enhancer, by its component of its parts by weight is: Caulis Spatholobi 20 ~ 30 parts, Herba Ecliptae 15 ~ 25 parts, Cortex Phellodendri 10 ~ 20 parts, Rhizoma Coptidis 3 ~ 13 parts, Fructus Rubi 3 ~ 13 parts, the Rhizoma Atractylodis Macrocephalae 3 ~ 13 parts, Herba Menthae 3 ~ 13 parts, 3 ~ 13 parts, Hemerocallis citrina Baroni.
As preferred component, by its component of its parts by weight be: Caulis Spatholobi 22 ~ 28 parts, Herba Ecliptae 17 ~ 23 parts, Cortex Phellodendri 12 ~ 18 parts, Rhizoma Coptidis 5 ~ 11 parts, Fructus Rubi 5 ~ 11 parts, the Rhizoma Atractylodis Macrocephalae 5 ~ 11 parts, Herba Menthae 5 ~ 11 parts, 5 ~ 11 parts, Hemerocallis citrina Baroni.
As preferred component, by its component of its parts by weight be: Caulis Spatholobi 24 ~ 26 parts, Herba Ecliptae 19 ~ 21 parts, Cortex Phellodendri 14 ~ 16 parts, Rhizoma Coptidis 7 ~ 9 parts, Fructus Rubi 7 ~ 9 parts, the Rhizoma Atractylodis Macrocephalae 7 ~ 9 parts, Herba Menthae 7 ~ 9 parts, 7 ~ 9 parts, Hemerocallis citrina Baroni.
As better composition, by its component of its parts by weight be: Caulis Spatholobi 25 parts, Herba Ecliptae 20 parts, Cortex Phellodendri 15 parts, Rhizoma Coptidis 8 parts, Fructus Rubi 8 parts, the Rhizoma Atractylodis Macrocephalae 8 parts, Herba Menthae 8 parts, 8 parts, Hemerocallis citrina Baroni.
Prepare the method for Chinese medicine immunity enhancer: namely take each component by weight, the baking oven being placed in 60 DEG C is dried at least after 10h, pulverizes with pulverizer, crosses mix homogeneously after 40 mesh sieves.
Crude drug of the present invention has following drug effect:
Caulis Spatholobi, the property of medicine is bitter, micro-sweet, and it contains the activity that flavone compound can improve cabrilla lymphokin activated killer cells and NK cell, also can promote the secretion of IL-3 and regulate hematocrit level, promoting leukocytic generation.
Herba Ecliptae, property of medicine sweet in the mouth, acid, cool in nature, it contains the flavone component of luteolin and quercetin, improving immunocompetence, also can stimulate cabrilla lymphopoiesis to transform, and improves cabrilla serum hemolysin, strengthen phagocytic activity and the NK cytoactive of the monokaryon-peritoneal macrophage of cabrilla, significantly improve the non-specific immunity such as bacterium enzyme, complement.
Cortex Phellodendri, the property of medicine is bitter, cold, and its chief active chemical composition alkaloids substance, can improve NBT positive cell number in cabrilla blood, can improve cabrilla leukocyte oxygen respiratory burst, also can improve cabrilla leukocytes phagocytic active.
Compared with prior art, the beneficial effect that the present invention has: the Caulis Spatholobi containing flavone compound, the Herba Ecliptae containing flavone component, the Cortex Phellodendri with alkaloids substance and Rhizoma Coptidis, Fructus Rubi, the Rhizoma Atractylodis Macrocephalae, Herba Menthae, these Chinese herbal medicine of Hemerocallis citrina Baroni are interacted, cabrilla leukocyte oxygen respiratory burst can be improved, also cabrilla leukocytes phagocytic can be improved active, the mean feed of effective reduction cabrilla is high and to improve survival rate low, immunostimulant effective.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described.
Embodiment 1
Take each component by weight: Caulis Spatholobi 30 parts, Herba Ecliptae 25 parts, Cortex Phellodendri 20 parts, Rhizoma Coptidis 13 parts, Fructus Rubi 3 parts, the Rhizoma Atractylodis Macrocephalae 3 parts, Herba Menthae 3 parts, 3 parts, Hemerocallis citrina Baroni.
Prepare immunostimulant: the baking oven each medical material being placed in 60 DEG C is dried at least after 10h, is ground into powder with pulverizer, cross mix homogeneously after 40 mesh sieves.
Consumption: the amount of adding the immunostimulant in epinephelus feed to is 0.1%.
Embodiment 2
Take each component by weight: Caulis Spatholobi 28 parts, Herba Ecliptae 23 parts, Cortex Phellodendri 18 parts, Rhizoma Coptidis 11 parts, Fructus Rubi 5 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, Herba Menthae 5 parts, 5 parts, Hemerocallis citrina Baroni.
Prepare immunostimulant: identical with embodiment 1.
Consumption: the amount of adding the immunostimulant in epinephelus feed to is 0.15%.
Embodiment 3
Take each component by weight: Caulis Spatholobi 25 parts, Herba Ecliptae 20 parts, Cortex Phellodendri 15 parts, Rhizoma Coptidis 8 parts, Fructus Rubi 8 parts, the Rhizoma Atractylodis Macrocephalae 8 parts, Herba Menthae 8 parts, 8 parts, Hemerocallis citrina Baroni.
Prepare immunostimulant: identical with embodiment 1.
Consumption: the amount of adding the immunostimulant in epinephelus feed to is 0.18%.
Embodiment 4
Take each component by weight: Caulis Spatholobi 23 parts, Herba Ecliptae 18 parts, Cortex Phellodendri 13 parts, Rhizoma Coptidis 6 parts, Fructus Rubi 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Herba Menthae 10 parts, 10 parts, Hemerocallis citrina Baroni.
Prepare immunostimulant: identical with embodiment 1.
Consumption: the amount of adding the immunostimulant in epinephelus feed to is 0.2%.
Embodiment 5
Take each component by weight: Caulis Spatholobi 20 parts, Herba Ecliptae 15 parts, Cortex Phellodendri 10 parts, Rhizoma Coptidis 3 parts, Fructus Rubi 13 parts, the Rhizoma Atractylodis Macrocephalae 13 parts, Herba Menthae 13 parts, 13 parts, Hemerocallis citrina Baroni.
Prepare immunostimulant: identical with embodiment 1.
Consumption: the amount of adding the immunostimulant in epinephelus feed to is 0.2%.
According to the immunostimulant that raw material in above-described embodiment 1 ~ 5 and preparation method thereof is made, add in epinephelus feed the cabrilla 3 months of feeding to, feeding effect is as shown in the table:
| Matched group | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | |
| Net cage number (only) | 40 | 40 | 40 | 40 | 40 | 40 |
| The mean feed | 1.55 | 1.37 | 1.35 | 1.32 | 1.38 | 1.40 |
| Feed coefficient reduces (%) | 11.6 | 13.0 | 14.9 | 11.0 | 10.0 | |
| Average survival | 75％ | 89％ | 90％ | 93％ | 87％ | 91％ |
| Survival rate improves (%) | 18.7 | 20.0 | 24.0 | 16.0 | 21.3 |
Experimental result shows: in the cycle of cabrilla cage culture, to use in this medicinal herbs immunostimulant as epinephelus feed additive, epinephelus feed does not reduce 11.6%, 13.0%, 14.9%, 11.0%, 10.0% than contrast component, on average reduces 12.1%; Survival rate improves 18.7%, 20.0%, 24.0%, 16.0%, 21.3% respectively, on average improves 20%.
It should be pointed out that above case is only the representational example of the present invention.Obviously, technical scheme of the present invention is not limited to above-described embodiment, can also have many degeneration.
Claims (4)
1. a cabrilla Chinese medicine immunity enhancer, is characterized in that, by its component of its parts by weight is: Caulis Spatholobi 20 ~ 30 parts, Herba Ecliptae 15 ~ 25 parts, Cortex Phellodendri 10 ~ 20 parts, Rhizoma Coptidis 3 ~ 13 parts, Fructus Rubi 3 ~ 13 parts, the Rhizoma Atractylodis Macrocephalae 3 ~ 13 parts, Herba Menthae 3 ~ 13 parts, 3 ~ 13 parts, Hemerocallis citrina Baroni.
2. a kind of cabrilla Chinese medicine immunity enhancer according to claim 1, it is characterized in that, by its component of its parts by weight be: Caulis Spatholobi 22 ~ 28 parts, Herba Ecliptae 17 ~ 23 parts, Cortex Phellodendri 12 ~ 18 parts, Rhizoma Coptidis 5 ~ 11 parts, Fructus Rubi 5 ~ 11 parts, the Rhizoma Atractylodis Macrocephalae 5 ~ 11 parts, Herba Menthae 5 ~ 11 parts, 5 ~ 11 parts, Hemerocallis citrina Baroni.
3. a kind of cabrilla Chinese medicine immunity enhancer according to claim 2, it is characterized in that, by its component of its parts by weight be: Caulis Spatholobi 24 ~ 26 parts, Herba Ecliptae 19 ~ 21 parts, Cortex Phellodendri 14 ~ 16 parts, Rhizoma Coptidis 7 ~ 9 parts, Fructus Rubi 7 ~ 9 parts, the Rhizoma Atractylodis Macrocephalae 7 ~ 9 parts, Herba Menthae 7 ~ 9 parts, 7 ~ 9 parts, Hemerocallis citrina Baroni.
4. a kind of cabrilla Chinese medicine immunity enhancer according to claim 3, is characterized in that, by its component of its parts by weight be: Caulis Spatholobi 25 parts, Herba Ecliptae 20 parts, Cortex Phellodendri 15 parts, Rhizoma Coptidis 8 parts, Fructus Rubi 8 parts, the Rhizoma Atractylodis Macrocephalae 8 parts, Herba Menthae 8 parts, 8 parts, Hemerocallis citrina Baroni.
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| CN201510453933.0A CN104940371A (en) | 2015-07-29 | 2015-07-29 | Chinese herbal medicine immunopotentiator for groupers |
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| CN201510453933.0A CN104940371A (en) | 2015-07-29 | 2015-07-29 | Chinese herbal medicine immunopotentiator for groupers |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106616050A (en) * | 2016-12-28 | 2017-05-10 | 青岛嘉瑞生物技术有限公司 | Biological method for preparing garrupa immunopotentiator from froggrass |
| CN107007618A (en) * | 2017-04-19 | 2017-08-04 | 天津农学院 | It is a kind of for the Radix Angelicae Sinensis polysaccharide immunopotentiator of grouper and its application |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104522310A (en) * | 2014-11-21 | 2015-04-22 | 滁州市长江渔业专业合作社 | Fish feed additive capable of clearing intestine and stopping diarrhea, and preparation method thereof |
-
2015
- 2015-07-29 CN CN201510453933.0A patent/CN104940371A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104522310A (en) * | 2014-11-21 | 2015-04-22 | 滁州市长江渔业专业合作社 | Fish feed additive capable of clearing intestine and stopping diarrhea, and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 孙树征等主编: "《口腔颌面肿瘤学》", 28 February 1995, 山东科学技术出版社 * |
| 胡元亮主编: "《新编中兽医验方与妙用》", 31 March 2009, 化学工业出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106616050A (en) * | 2016-12-28 | 2017-05-10 | 青岛嘉瑞生物技术有限公司 | Biological method for preparing garrupa immunopotentiator from froggrass |
| CN107007618A (en) * | 2017-04-19 | 2017-08-04 | 天津农学院 | It is a kind of for the Radix Angelicae Sinensis polysaccharide immunopotentiator of grouper and its application |
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Application publication date: 20150930 |