CN108992448B - Salt-containing degerming tablet for aquarium fish and preparation method thereof - Google Patents
Salt-containing degerming tablet for aquarium fish and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A61K31/51—Thiamines, e.g. vitamin B1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Abstract
The invention discloses a salt-containing degerming tablet for aquarium fishes and a preparation method thereof, belonging to the field of Chinese herbal medicines. The salt-containing degerming tablet for the aquarium fish comprises the following components in parts by weight: 10-30 parts of special culture salt, 10-20 parts of compound vitamin, 40-60 parts of compound mineral substance, 1-20 parts of methyl blue, 1-20 parts of malachite green, 5-15 parts of medicine, 1-10 parts of filler, 1-10 parts of adhesive, 1-10 parts of lubricant and 1-10 parts of effervescent disintegrant. The salt-containing degerming tablet for the aquarium fish has a good treatment effect on fungi and parasites, and is quick in effect and good in action effect; meanwhile, the preparation method is simple, and the tablets are convenient to transport and suitable for large-scale popularization and application.
Description
Technical Field
The invention relates to the technical field of aquarium fish culture, and particularly provides a salt-containing degerming tablet for aquarium fish and a preparation method thereof.
Background
The ornamental fish is fish with ornamental value, bright colors or peculiar shapes, and is favored by people due to gorgeous colors. However, in the feeding process, improper feeding can cause diseases or various defects of the fishes, and the ornamental value of the fishes is influenced.
In the prior art, when the ornamental fish is disinfected and treated, the first choice of medicine is the salt, and the salt is added to play a certain role in sterilization and prevention, but the effect on fish with existing diseases is small. In the prior art, related reports are also provided about a sterilization liquid which can not only treat and prevent diseases, but also sterilize water.
Patent CN102550609A discloses a marine organism aquaculture sterilization liquid, which can be used for treating and preventing common bacterial diseases of cultured ginseng, fish, shrimp and crab in the aquaculture process, and can also be used for purifying and disinfecting aquaculture water. The sterilization rate of various pathogenic bacteria bred in the breeding process reaches more than 99.999 percent, is nontoxic, nonirritating and unchangeable to the cultured crops, can perform the sterilization function on the culture water body, has long-acting antibacterial activity, can effectively maintain the water body environment, and reduces the chance of causing diseases to the cultured substances. Simple production process, low cost and no environmental pollution. However, the product of the invention can only prevent and treat related diseases, and related nutrient components are required to be added additionally to ensure the healthy growth of fishes, and meanwhile, the product of the invention is liquid and is difficult to transport.
Disclosure of Invention
The invention provides a salt-containing degerming tablet for ornamental fish and a preparation method thereof.
In order to solve the technical problems, the invention provides the following technical scheme:
the invention provides a salt-containing degerming tablet for aquarium fishes, which consists of the following components in parts by weight:
10-30 parts of special culture salt
10-20 parts of compound vitamin
40-60 parts of compound mineral
1-20 parts of methyl blue
1-20 parts of malachite green
5-15 parts of medicine
1-10 parts of filler
1-10 parts of adhesive
1-10 parts of lubricant
1-10 parts of effervescent disintegrant.
Preferably, the salt-containing sterilization tablet for the aquarium fish comprises the following components in parts by weight:
20-30 parts of special culture salt
15-20 parts of compound vitamin
50-60 parts of compound mineral
10-20 parts of methyl blue
10-20 parts of malachite green
10-15 parts of medicine
5-10 parts of filler
5-10 parts of adhesive
5-10 parts of lubricant
5-10 parts of effervescent disintegrant.
Preferably, the salt-containing sterilization tablet for the aquarium fish comprises the following components in parts by weight:
25 parts of special culture salt
20 portions of compound vitamin
55 parts of compound mineral
15 parts of methyl blue
10 portions of malachite green
15 portions of medicine
8 portions of filler
10 portions of adhesive
10 portions of lubricant
8 parts of effervescent disintegrant.
Further, the medicine is mequindox and/or furazolidone which are used simultaneously, and the weight ratio is 1: 1; the weight ratio of the methyl blue to the malachite green is 1.5: 1.
the mequindox is a broad-spectrum antibacterial drug, the antibacterial mechanism is to inhibit DNA synthesis of thalli, and the mequindox has strong inhibition effect on most bacteria. Has stronger effect on gram-negative bacteria. Meanwhile, the mequindox has good safety and good absorption after oral administration. Has special effects on bacterial muscle bleeding, gill cover bleeding, fin ray bleeding, body surface bleeding and visceral bleeding of fish. Has good curative effect on bacterial diseases such as enteritis, gill rot, red skin, vertical scale, exophthalmos, and the like of various fishes.
Furazolidone has certain antibacterial effect on gram positive bacteria and gram negative bacteria, and has antibacterial effect on salmonella, shigella, escherichia coli, proteus, streptococcus, staphylococcus and the like. The bacteria are not easy to generate drug resistance to furazolidone and have no cross drug resistance with sulfanilamide and antibiotics. Has good effect on fish enteritis and gill rot of fish.
The methyl blue has good treatment effect on fish ichthyophthiriasis, saprolegniasis, oral floss, scale frying, tail rot, gill rot, white mouth, skin diseases caused by the pipe worms and the trichina, and the like, wherein the treatment effect on the saprolegniasis is optimal.
Malachite green can be used for treating parasite, fungus or bacteria infection of fish or roe, and has special effect on saprolegniasis. Malachite green is also often used to treat freshwater aquatic products affected by parasites.
The mequindox and furazolidone are used as main components, the methyl blue and the malachite green are used as auxiliary components, and the four components act together to effectively treat and prevent diseases generated in the ornamental fish culture process.
Preferably, the vitamin complex is at least two of vitamin a, vitamin D3 and vitamin B2; the composite mineral is at least two of medical stone, bentonite and zeolite.
Generally, fish bodies cannot synthesize vitamins, but the vitamins play an important role in the metabolic process of the fish, and deficiency of the vitamins can cause metabolic disturbance and deficiency. Meanwhile, the mineral elements are important to the nutrition of the fish, and can effectively maintain the osmotic pressure balance between the body fluid of the fish and the surrounding water. However, the fish is poisoned chronically due to excessive addition, excessive mineral elements can inhibit the victory activity of enzyme and change the activity of biomacromolecule, thereby causing the change of the shape, physiology and behavior of the fish and being unfavorable for the growth of the fish. According to the invention, vitamins and mineral elements required by growth of fish are provided by adding the compound vitamins and compound minerals, so that deficiency caused by deficiency of vitamins and mineral elements in the growth process is avoided.
Preferably, the filler is one or more of starch, dextrin and microcrystalline cellulose.
Preferably, the adhesive is an ethanol solution with the concentration of PEG4000 or PEG6000 being 18wt% -20 wt%.
Preferably, the lubricant is one or more of ethanol, calcium stearate and sodium lauryl sulfate.
Further, the effervescent disintegrant is a mixture of 1: 1.2-1.5 of a mixture of sodium bicarbonate and citric acid.
The invention also provides a preparation method of the salt-containing degerming tablet for the aquarium fish, which comprises the following steps:
step 1: pulverizing the special salt for cultivation, compound vitamins, compound minerals, methyl blue, malachite green, medicine, filler, lubricant, and effervescent disintegrant, and sieving with 80-100 mesh sieve;
step 2: adding adhesive, granulating, drying at 50 deg.C, and tabletting to obtain salt-containing degerming tablet for aquarium fish.
Further, each tablet is 5-10g, and when the tablet is used for prevention, 1 tablet is put into 50L of water body every 3 days; when the diseased fish is treated, 0.5g of the tablet prepared by the invention is put into 1Kg of fish every day for 4-6 days, and then the feeding is changed into preventive feeding.
Compared with the prior art, the invention has the following beneficial effects:
the invention provides a salt-containing degerming tablet for aquarium fish and a preparation method thereof, wherein mequindox and furazolidone are taken as main components, and methyl blue and malachite green are taken as auxiliary components, so that bacteria can be killed quickly and efficiently, and diseases can be prevented; the invention also contains compound vitamins and compound minerals, provides relative nutrient substances for the growth of fishes and prevents deficiency diseases; the invention is prepared into tablets, is convenient to transport, has simple preparation method and is suitable for large-scale popularization and application.
Detailed Description
In order to make the technical problems, solutions and advantages of the present invention more apparent, specific embodiments will be described in detail below, but the present invention is by no means limited to these examples. The following description is only a preferred embodiment of the present invention, and is only for the purpose of explaining the present invention, and should not be construed as limiting the scope of the present invention. It should be understood that any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
The components used in the present invention are all commercially available products unless otherwise specified.
The invention provides a salt-containing degerming tablet for aquarium fishes and a preparation method thereof, and the specific embodiment is as follows.
Example 1
A salt-containing degerming tablet for aquarium fishes comprises the following components in parts by weight:
10 portions of special culture salt
10 portions of vitamin A
Vitamin D310 parts
20 portions of medical stone
20 portions of bentonite
20 parts of methyl blue
1 part of malachite green
Dysentery stopping 15 parts
Dextrin 10 parts
1 part of 18wt% PEG4000 ethanol solution
Ethanol 1 part
Sodium bicarbonate 0.45 part
0.55 part of citric acid.
Example 2
A salt-containing degerming tablet for aquarium fishes comprises the following components in parts by weight:
30 portions of special culture salt
2 portions of vitamin A
Vitamin D34 parts
24 parts of vitamin B
20 portions of medical stone
25 portions of bentonite
15 portions of zeolite
Methyl blue 1 part
20 portions of malachite green
Furazolidone 5 parts
Starch 1 portion
10 parts of ethanol solution of 18wt% PEG6000
10 portions of calcium stearate
Sodium bicarbonate 4.5 parts
5.5 parts of citric acid.
Example 3
A salt-containing degerming tablet for aquarium fishes comprises the following components in parts by weight:
20 portions of special culture salt
8 portions of vitamin A
Vitamin D36 parts
26 parts of vitamin B
20 portions of medical stone
Zeolite 30 parts
20 parts of methyl blue
10 portions of malachite green
Dysentery stopping 7.5 shares
Furazolidone 7.5 parts
10 portions of microcrystalline cellulose
10 parts of 20wt% PEG6000 ethanol solution
10 portions of lauryl sodium sulfate
Sodium bicarbonate 2.25 parts
2.75 parts of citric acid.
Example 4
A salt-containing degerming tablet for aquarium fishes comprises the following components in parts by weight:
30 portions of special culture salt
4 portions of vitamin A
Vitamin D37 parts
24 parts of vitamin B
10 portions of medical stone
30 portions of bentonite
20 portions of zeolite
10 parts of methyl blue
20 portions of malachite green
Dysentery stopping 5 parts
Furazolidone 5 parts
2 portions of starch
Dextrin 3 parts
10 parts of 20wt% PEG4000 ethanol solution
3 portions of calcium stearate
Sodium dodecyl sulfate 2 parts
Sodium bicarbonate 4.5 parts
5.5 parts of citric acid.
Example 5
A salt-containing degerming tablet for aquarium fishes comprises the following components in parts by weight:
25 parts of special culture salt
10 portions of vitamin A
Vitamin D38 parts
27 parts of vitamin B
15 portions of medical stone
20 portions of bentonite
20 portions of zeolite
15 parts of methyl blue
10 portions of malachite green
Dysentery stopping 7.5 shares
Furazolidone 7.5 parts
Dextrin 4 parts
Microcrystalline cellulose 4 parts
10 parts of 20wt% PEG46000 ethanol solution
3 portions of ethanol
2 portions of calcium stearate
Sodium dodecyl sulfate 5 parts
Sodium bicarbonate 3.6 parts
4.4 parts of citric acid.
Example 6
A salt-containing degerming tablet for aquarium fishes comprises the following components in parts by weight:
22 portions of special culture salt
6 portions of vitamin A
Vitamin D36 parts
26 parts of vitamin B
20 portions of medical stone
20 portions of bentonite
16 portions of zeolite
18 parts of methyl blue
Malachite green 12 parts
6 portions of mequindox
Furazolidone 6 parts
Dextrin 3 parts
Microcrystalline cellulose 5 parts
7 parts of 20wt% PEG46000 ethanol solution
Ethanol 1 part
3 portions of calcium stearate
Sodium dodecyl sulfate 5 parts
Sodium bicarbonate 3.6 parts
4.4 parts of citric acid.
The invention also provides a preparation method of the salt-containing degerming tablet for the aquarium fish, which comprises the following steps:
step 1: pulverizing the special salt for cultivation, compound vitamins, compound minerals, methyl blue, malachite green, medicine, filler, lubricant, and effervescent disintegrant, and sieving with 80-100 mesh sieve;
step 2: adding adhesive, granulating, drying at 50 deg.C, and tabletting to obtain salt-containing degerming tablet for aquarium fish.
Each tablet is 5-10g, and when the tablet is used for prevention, 1 tablet is put into 50L of water body every 3 days; when the diseased fish is treated, 0.5g of the tablet prepared by the invention is put into 1Kg of fish, 2 times a day for 4-6 days continuously, and then the preventive putting is carried out.
For space limitation, to further prove the effect of the salt-containing sterilizing tablet for aquarium fish prepared by the present invention, a comparative example was constructed as follows, taking only example 5 as an example.
Comparative example 1
This comparative example omits the multivitamin and the remaining components and amounts are the same as in example 5.
Comparative example 2
This comparative example omits the complex mineral, and the remaining components and amounts are the same as in example 5.
Comparative example 3
This comparative example omits methyl blue and the remaining components and amounts are the same as in example 5.
Comparative example 4
This comparative example omits malachite green and the remaining components and amounts are the same as in example 5.
Comparative example 5
This comparative example omits methyl blue and malachite green and the remaining components and amounts are the same as in example 5.
Comparative example 6
In the comparative example, mequindox is omitted, and the other components and the use amount are the same as those in example 5.
Comparative example 7
This comparative example omits furazolidone and the remaining components and amounts are the same as in example 5.
Comparative example 8
In the comparative example, mequindox and furazolidone are omitted, and the other components and the use amount are the same as those in example 5.
Comparative example 9
This comparative example omits the multivitamins and furazolidone and the remaining components and amounts are the same as in example 5.
The above comparative examples 1-6 were prepared and used in the same manner as provided by the present invention.
The tablets prepared in the above examples 1 to 6 and comparative examples 1 to 9 were tested for the control effect on common pathogenic bacteria of fish including myxococcus, trichobacter luciferin and other bacteria and on insects such as ichthyophthirius multifiliis, trichodina obliqua and the like.
16 glass aquariums containing 100L of water are filled with fully aerated tap water, the sewage is cleaned by a siphon method in the experimental process, the water is changed twice, the water change amount is 1/5 of the total water amount each time, the water temperature is 20-28 ℃, and the pH value is about 7, so that the aquarium is used for feeding goldfishes.
Screening goldfish to obtain goldfish with black fish body, congestion mouth, pale gill, scale falling off and other phenomena, and after autopsy analysis, the goldfish is found to be red skin, enteritis and gill rot caused by mixed infection of pseudomonas fluorescens, pseudomonas punctatus and myxococcus. The naturally occurring goldfishes were placed into the above aquariums, 50 in each glass aquarium. Respectively putting the bait containing the tablets prepared in the examples 1 to 6 and the comparative examples 1 to 9 of the invention into 15 aquariums, wherein the concentration of the tablets prepared in the invention is 1.5 percent of the bait, feeding the tablets for 2 times every day, and putting 2 tablets every 3 days after 6 days; the other aquarium was set as a control group and the same amount of bait was administered, but without the tablets of the present invention.
The death and survival of the fish bodies on days 1, 3, 6, 9, 15 and 30 after feeding the fish bodies in the above aquarium were observed as shown in Table 1.
TABLE 1
As can be seen from Table 1, the degerming tablet prepared by the invention has better effect on diseases such as red skin, enteritis, gill rot and the like caused by pseudomonas fluorescens, aeromonas punctata and myxococcus. Compared with the comparative example, the tablets prepared in the examples 1 to 6 of the invention have better effect on the 1 st day, and generally no fish die any more in the last 6 days, so that the disease can be better controlled; in comparative examples 1 to 9, some ingredients in the present invention were reduced, and the composition also had bactericidal effect, but had slow onset of action, and further, fish death occurred, and the death rate was much higher than that of the tablets prepared in the examples of the present invention, demonstrating that only the complete formulation of the present invention acts simultaneously, and the treatment effect on the above-mentioned diseases was the best.
The tablets prepared in the examples and comparative examples of the present invention were examined for their parasite control effects: putting 50 goldfishes in each aquarium, and carrying out parasite (such as ichthyophthirius multifiliis, syphonaptera and the like) infection experiments, wherein 1 piece of goldfishes is put in 50L of water in the experiment process, and the putting is carried out once every 3 days; the control group was not dosed with any drug and the observed effect is shown in table 2.
TABLE 2
As can be seen from Table 2, the degerming tablet prepared by the invention has better effect on fish parasites. Compared with the comparative example, the cure rate of the tablets prepared in the examples 1 to 6 is over 90 percent; in comparative examples 1 to 9, some ingredients of the present invention were reduced to exert a certain effect as compared with the control group, but the cure rate was much lower than that of the tablets prepared in the examples of the present invention, demonstrating that only the complete formulation of the present invention acts simultaneously and the treatment effect on the above-mentioned conditions is the best.
In conclusion, the salt-containing degerming tablet for the aquarium fish has a good treatment effect on fungi and parasites, and is quick in effect and good in action effect; meanwhile, the preparation method is simple, and the tablets are convenient to transport and suitable for large-scale popularization and application.
While the foregoing is directed to the preferred embodiment of the present invention, it will be understood by those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (4)
1. The salt-containing degerming tablet for the aquarium fishes is characterized by comprising the following components in parts by weight:
the medicine is mequindox and furazolidone; the weight ratio of the methyl blue to the malachite green is 1.5: 1;
the compound vitamin is at least two of vitamin A, vitamin D3 and vitamin B2; the composite mineral is at least two of medical stone, bentonite and zeolite;
the filler is one or more of starch, dextrin and microcrystalline cellulose;
the adhesive is an ethanol solution with the concentration of 18wt% -20wt% of PEG4000 or PEG 6000;
the lubricant is one or more of ethanol, calcium stearate and sodium dodecyl sulfate;
the effervescent disintegrant is prepared from the following components in a mass ratio of 1: 1.2-1.5 of a mixture of sodium bicarbonate and citric acid.
2. The salt-containing sterilization tablet for the aquarium fish according to claim 1, which is characterized by comprising the following components in parts by weight:
3. the salt-containing sterilization tablet for the aquarium fish according to claim 2, which is characterized by comprising the following components in parts by weight:
4. the method for preparing a salt-containing sterilizing tablet for aquarium fishes as claimed in any one of claims 1 to 3, comprising:
step 1: pulverizing the special salt for cultivation, compound vitamins, compound minerals, methyl blue, malachite green, medicine, filler, lubricant, and effervescent disintegrant, and sieving with 80-100 mesh sieve;
step 2: adding adhesive, granulating, drying at 50 deg.C, and tabletting to obtain salt-containing degerming tablet for aquarium fish.
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