CN110624016B - Composition for preventing and treating streptococcicosis of sturgeon and application thereof - Google Patents
Composition for preventing and treating streptococcicosis of sturgeon and application thereof Download PDFInfo
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Abstract
The invention provides a composition for preventing and treating streptococcicosis of sturgeon and application thereof, belonging to the technical field of aquatic disease control, wherein the composition comprises the following components: immunopotentiator, vitamin C, three-yellow powder, streptogramine and florfenicol. The composition is applied to sturgeon culture, the survival rate of sturgeons with streptococcal diseases can reach 80-90%, and the cross infection of large-area culture can be effectively prevented. The composition provided by the invention is convenient to use, small in dosage, short in treatment course, good in curative effect, capable of effectively killing streptococcus iniae, good in disease control effect of diseased fish, not easy to repeat, greatly improves the survival rate of diseased fish, and reduces the economic loss of farmers.
Description
Technical Field
The invention relates to the technical field of aquatic disease control, in particular to a composition for preventing and treating streptococcicosis of sturgeon and application thereof.
Background
Sturgeon (Sturgeon) is the oldest fish with large body size and long service life in the existing fishes in the world. In recent years, with the market promotion, the sturgeon industry is also developing toward large-scale specialization, and enterprises and individual culture units form a system step by step. However, the deterioration of the environment and the excessive application of the medicine bring corresponding problems, namely, the drug resistance of sturgeon pathogenic bacteria is continuously improved and changed, and the streptococcus iniae is particularly prominent. The lethal symptoms of sturgeon infection with streptococcus iniae are as follows: the anus is red and swollen, the blood is discharged around the mouth of the snout, the tail end of the intestinal tract is congested, the death rate is high, and the death rate is not effectively prevented and controlled to reach 90%.
Disclosure of Invention
The invention aims to provide a composition for preventing and treating streptococcicosis of sturgeons and application thereof.
In order to achieve the above object, the present invention provides the following technical solutions:
the invention provides a composition for preventing and treating streptococcicosis of sturgeon, which comprises the following components: immunopotentiator, vitamin C, three-yellow powder, streptogramine and florfenicol.
Preferably, the immunopotentiator comprises allicin.
Preferably, the mass ratio of the streptogramins to the florfenicol is 6-8: 2-4; the mass ratio of the immunopotentiator to the vitamin C to the three-yellow powder is 10-15: 1-2: 4-8.
The invention also provides application of the composition in the scheme in sturgeon culture, wherein the application comprises prevention and treatment;
the prevention comprises the steps of carrying out first disinfection on the net cage and carrying out second disinfection on sturgeon fries;
the treatment comprises feeding with immunopotentiator, vitamin C, SANHUANG powder, streptococcal agent and florfenicol; the feeding comprises the following steps: the mixture of the streptomycin and the florfenicol is fed, 6-8 days are taken as a treatment course, 2-4 treatment courses are fed, the interval between every two treatment courses is 6-8 days, and 6-8 days of the interval between every two treatment courses are fed with an immunopotentiator, vitamin C and tribasic yellow powder.
Preferably, the disinfectant used for the first disinfection comprises an iodine preparation and/or chlorine dioxide.
Preferably, the dosage of the iodine preparation is 200-300 mL per mu per meter of water depth; the dosage of the chlorine dioxide is 2-4 g/m3。
Preferably, the disinfectant used for the second disinfection comprises povidone iodine or glutaraldehyde water solution; the concentration of the povidone iodine is 45-55 ppm; the concentration of the glutaraldehyde water solution is 25-35 ppm.
Preferably, the second disinfection time is 3-5 min.
Preferably, the immunopotentiator, the vitamin C and the three-yellow powder are fed in a mode of mixing materials; the weight ratio of the immunopotentiator to the feed is 10-15: 1000; the weight ratio of the vitamin C to the feed is 1-2: 1000; the weight ratio of the three-yellow powder to the feed is 4-8: 1000.
Preferably, the feeding times of the streptomycin and the florfenicol are 1-3 times per day; the total feeding amount of the streptomycin and the florfenicol is 0.12-0.15 g per kilogram of fish bodies.
The invention has the beneficial effects that: the invention provides a composition for preventing and treating streptococcicosis of sturgeon, which comprises the following components: immunopotentiator, vitamin C, three-yellow powder, streptogramine and florfenicol. The composition is applied to sturgeon culture, the survival rate of sturgeons with streptococcal diseases can reach 80-90%, and the cross infection of large-area culture can be effectively prevented. The composition provided by the invention is convenient to use, small in dosage, short in treatment course, good in curative effect, capable of effectively killing streptococcus iniae, good in disease control effect of diseased fish, not easy to repeat, greatly improves the survival rate of diseased fish, and reduces the economic loss of farmers.
Detailed Description
The invention provides a composition for preventing and treating streptococcicosis of sturgeon, which comprises the following components: immunopotentiator, vitamin C, three-yellow powder, streptococcal agent and florfenicol; the mass ratio of the streptogramins to the florfenicol is preferably 6-8: 2-4, and more preferably 7: 3; the mass ratio of the immunopotentiator to the vitamin C to the three-yellow powder is preferably 10-15: 1-2: 4-8, and more preferably 12-14: 1.5-1.8: 6.
In the present invention, the immunopotentiator includes allicin; the immunopotentiator has the function of enhancing the nonspecific immunity resistance of the fish to pathogenic infection; the allicin has the function of enhancing the nonspecific immunity resistance of the fish to pathogenic infection and can also condition intestines and stomach; the immunopotentiator is from conventional commercial sources; the three-yellow powder mainly comprises rhubarb, scutellaria and phellodendron, and is from conventional markets; the vitamin C is from conventional market; the vitamin C and the three-yellow powder are used for feeding the sturgeon fries, so that the anti-stress capability of the sturgeon fries can be improved.
In the invention, the florfenicol can be irreversibly combined with a receptor site of a bacterial ribosome 50S subunit, blocks peptide acyl transfer, inhibits peptide chain extension from interfering protein synthesis, generates an antibacterial action and has stronger antibacterial action on aeromonas, vibrio, edwardsiella and the like; the streptomyces can treat bacterial diseases caused by aeromonas, pseudomonas fluorescens, edwardsiella tarda, vibrio anguillarum and the like; in the specific implementation process of the invention, the florfenicol is purchased from Beijing Baozhengtang biotechnology limited company; the streptomyces was purchased from Hengda Leao Biotechnology Ltd in Shanxi.
In the invention, the immunopotentiator, the vitamin C, the three-yellow powder, the streptomycin and the florfenicol in the composition are respectively and independently packaged.
The invention also provides application of the composition in the scheme in sturgeon culture, wherein the application comprises prevention and treatment;
the prevention comprises the steps of carrying out first disinfection on the net cage and carrying out second disinfection on sturgeon fries;
the treatment comprises feeding with immunopotentiator, vitamin C, SANHUANG powder, streptococcal agent and florfenicol; the feeding comprises the following steps: the mixture of the streptomycin and the florfenicol is fed, 6-8 days are taken as a treatment course, 2-4 treatment courses are fed, the interval between every two treatment courses is 6-8 days, and 6-8 days of the interval between every two treatment courses are fed with an immunopotentiator, vitamin C and tribasic yellow powder.
In the invention, the prevention comprises the first disinfection of the net cage; the disinfectant used for the first disinfection preferably comprises an iodine preparation and/or chlorine dioxide; the iodine preparation is preferably povidone iodine; the dosage of the iodine preparation is preferably 200-300 mL per mu per meter of water depth, and more preferably 250 mL; the preferable dosage of the chlorine dioxide is 2-4 g/m3More preferably 3g/m3(ii) a The first disinfection function is pathogen killing.
In the invention, the prevention comprises secondary disinfection of sturgeon fry; the disinfectant used for the second disinfection preferably comprises povidone iodine or glutaraldehyde aqueous solution; the concentration of the povidone iodine is preferably 45-55 ppm, and more preferably 50 ppm; the concentration of the glutaraldehyde water solution is preferably 25-35 ppm, and more preferably 30 ppm; the second disinfection time is preferably 3-5 min, and more preferably 4 min; preferably, the second disinfection mode is to adopt povidone iodine or glutaraldehyde water solution to dip and bath the sturgeon fries; the immersion bath is used for sterilizing sturgeon fry; and the sufficient dissolved oxygen of the water body is ensured in the dipping process.
In the invention, the prevention preferably further comprises net cage cleaning, and specifically comprises the cleaning of the net cage body and bottom stains and attachments.
In the invention, the prevention preferably further comprises feeding the fish fries with an immunopotentiator to enhance the nonspecific immunity resistance of the fish to pathogenic infection; the feeding mode is preferably bait mixing feeding; the feeding time is preferably 1-4 weeks, and more preferably 2-3 weeks; the feeding amount of the immunopotentiator is preferably 5 to 15 percent of the bait by weight, more preferably 8 to 12 percent of the bait by weight, and most preferably 10 percent of the bait by weight; the feeding amount of the bait is not particularly limited by the invention, and is subject to the conventional dosage in the field.
In the invention, the prevention preferably further comprises the step of feeding the sturgeon fries with vitamin C and three-yellow croaker powder so as to improve the anti-stress capability of the sturgeon fries; the feeding time is preferably before the disease high-incidence period; the feeding mode is preferably mixing feeding; the feeding amount of the vitamin C is preferably 1.2-1.8 g per kilogram of feed, and more preferably 1.5 g; the feeding amount of the three-yellow powder is preferably 4-8 g per kilogram of feed, and more preferably 6 g; the feeding amount of the feed is not particularly limited, and is subject to the conventional dosage in the field.
In the invention, the treatment comprises feeding by using an immunopotentiator, vitamin C, tribasic yellow powder, streptococcal agent and florfenicol; the feeding comprises the following steps: feeding after mixing the streptogramins and the florfenicol, taking 6-8 d as a treatment course, feeding for 2-4 treatment courses, wherein the interval between every two treatment courses is 6-8 d, and feeding the immunopotentiator, the vitamin C and the three-yellow powder every 6-8 d; the feeding time is preferably after disease occurrence, and is used for treating diseases.
In the invention, the immunopotentiator, the vitamin C and the three-yellow powder are preferably fed by mixing materials; the weight ratio of the immunopotentiator to the feed is preferably 10-15: 1000, and more preferably 12-14: 1000; the weight ratio of the vitamin C to the feed is preferably 1-2: 1000, and more preferably 1.5-1.8: 1000; the weight ratio of the three-yellow powder to the feed is preferably 4-8: 1000, and more preferably 6: 1000.
In the invention, the feeding times of the streptomycin and the florfenicol are preferably 1-3 times per day, more preferably 2 times per day, and more preferably once in the morning and at night; the total feeding amount of the streptomycin and the florfenicol is preferably 0.12-0.15 g per kilogram of fish bodies, and more preferably 0.13-0.14 g per kilogram of fish bodies.
In the present invention, the treatment preferably further comprises treating diseased fish; the step of treating the diseased fish comprises cleaning the diseased fish and disinfecting and deeply burying the diseased fish; the specific process for treating the diseased fish can be realized by adopting a conventional method in the field; the function of the treatment of diseased fish is to avoid the spread of pathogens.
In the invention, the treatment preferably further comprises sterilizing the aquaculture water body; the preferred mode of disinfecting the aquaculture water body comprises sprinkling a disinfectant or adopting a slow-release disinfectant hanging bag for disinfection; the disinfectant preferably comprises an iodine preparation and/or chlorine dioxide; the iodine preparation is preferably compound trioxodine; in the specific implementation process of the invention, the dosage of the iodine preparation and/or the chlorine dioxide is preferably splashed by one mu of dosage in the specification according to each net cage (6m multiplied by 6 m); the sprinkling speed is not specially limited, and the constant-speed sprinkling at the conventional speed can be adopted on the basis of the principle of less sprinkling and slow use; when the disinfection mode is a sprinkling disinfectant, the time for disinfecting the aquaculture water body is preferably more than or equal to 30 min; the invention forbids the copper sulfate and the strong chlorine essence to disinfect the culture water body.
The technical solutions provided by the present invention are described in detail below with reference to examples, but they should not be construed as limiting the scope of the present invention.
Example 1A farming method for the prevention and treatment of streptococcicosis in sturgeons
1. Prophylactic regimens
1) Net cage cleaning
Before throwing the seedlings, thoroughly decontaminating the culture net cage and the bottom to remove attachments, and using chlorine dioxide (3 g/m)3) Sterilizing the net cage to kill residual pathogen.
2) Sterilizing of seedlings
Soaking newly-entered fry with 50ppm povidone iodine for 3min before feeding fry, and placing into net cage, wherein the soaking process needs to be carried out with sufficient dissolved oxygen in water.
3) Enhancing resistance
The newly-thrown fry is added with allicin in bait according to 0.04g per kilogram of fish body and fed for 1 week to regulate intestines and stomach and enhance the nonspecific immunity resistance of the fish to pathogenic infection.
4) Preventing the onset of disease
Before the disease high-incidence period, the feed is additionally fed with vitamin C (1.5 g per kg of feed) and Sanhuang powder (6 g per kg of feed), so that the anti-stress capability of the fish is improved.
2. Treatment regimens
1) Diseased fish treatment
The fish which are discovered to be ill and dead need to be cleaned in time and disinfected and deeply buried, so as to avoid pathogen transmission.
2) Medical treatment
The streptomycin and the florfenicol are mixed and fed twice a day (once in the morning and at night), the immunopotentiator is added and fed every night, 7 days are taken as a treatment course, 3 treatment courses are used continuously, and the interval of each treatment course is 7 days. In the period of drug withdrawal, an immunopotentiator (12 g per kg of feed), vitamin C (1.5 g per kg of feed) and Chinese herbal medicine Sanhuang powder (6 g per kg of feed) are mixed and fed for feeding.
3) Water disinfection
The iodine preparation is adopted to be completely sprinkled for disinfection, the sprinkling is consistent with the principle of slow sprinkling, and the medicine is sprinkled at a uniform speed according to the dose of one mu on a specification of each net cage with the size of 6m multiplied by 6m and is used up for 35 min. (instructions for the preparation from iodine)
Example 2A farming method for the prevention and treatment of streptococcicosis in sturgeons
1. Prophylactic regimens
1) Net cage cleaning
Before seedling throwing, the culture net cage and the bottom are thoroughly decontaminated to remove attachments, and the net cage is disinfected by compound trioxodine (250 ml per mu and per meter of water depth) to kill residual pathogens.
2) Sterilizing of seedlings
30ppm glutaraldehyde solution is soaked for 5min before the newly-fed fry is put into a net cage, and the dissolved oxygen in water is sufficient when soaking.
3) Enhancing resistance
The newly-thrown fry is fed with allicin in the bait according to 10% of the daily ration for 1 week to regulate intestines and stomach and enhance the nonspecific immunity resistance of the fish to pathogenic infection.
4) Preventing the onset of disease
Before the disease high-incidence period, the feed is additionally fed with vitamin C (1.5 g per kg of feed) and Sanhuang powder (6 g per kg of feed), so that the anti-stress capability of the fish is improved.
2. Treatment regimens
1) Diseased fish treatment
The fish which are discovered to be ill and dead need to be cleaned in time and disinfected and deeply buried, so as to avoid pathogen transmission.
2) Medical treatment
The streptomycin and the florfenicol are mixed and fed twice a day (once in the morning and at night), the immunopotentiator is added and fed every night, 7 days are taken as a treatment course, 3 treatment courses are used continuously, and the interval of each treatment course is 7 days. In the period of drug withdrawal, an immunopotentiator (12 g per kg of feed), vitamin C (1.5 g per kg of feed) and Chinese herbal medicine Sanhuang powder (6 g per kg of feed) are mixed and fed for feeding.
3) Water disinfection
The chlorine dioxide is used for disinfection by fully sprinkling, the principle of slow sprinkling is to be adhered to, and the medicines are uniformly sprinkled according to the dosage of one mu on a specification of each net cage with the size of 6m multiplied by 6m and are used up for 40 min.
Example 3
Taking 200 diseased hybrid sturgeons with the size of 15-30 cm, and randomly extracting 50 hybrid sturgeons from each group of four groups (A, B, C, D) in the experiment. Group A is blank control group; group B is an immune enhancement group; group C is administration group; group D is dosing group + immune enhancing group.
The test process comprises the following steps:
group a was fed with normal feed twice a day during the entire test period;
and B group is fed with immunopotentiator, vitamin C and Sanhuang powder in a mixing manner in the whole test period, the dosage of the immunopotentiator (12 g per kg of feed), the dosage of the vitamin C (1.5 g per kg of feed) and the dosage of the Chinese herbal medicine Sanhuang powder (6 g per kg of feed) are combined in the morning and evening every day.
Group C was fed with strep-tezine and florfenicol twice a day (once in the morning and evening) for 7 days as a course of treatment, followed by 3 courses with 7 days intervals between each course of treatment.
Group D was fed with strepazidin and florfenicol twice a day (once in the morning and at night) during the test period, the immunopotentiator was combined with the feed every night for 7 days as a course of treatment, followed by 3 courses of treatment, with 7 days in each course of treatment. In the period of drug withdrawal, an immunopotentiator (12 g per kg of feed), vitamin C (1.5 g per kg of feed) and Chinese herbal medicine Sanhuang powder (6 g per kg of feed) are mixed and fed for feeding.
And (3) test results: after 3 treatment periods, group a died (43) tails with mortality (86%); group B died (29) tails with mortality of (58%); group C died (15) tails with mortality (30%); group D died (11) tails with a mortality rate of (22%); compared with the D group, the test shows that the mortality is the lowest, the survival rate reaches (78%), and the medicine has good treatment effect.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (8)
1. A composition for preventing and treating streptococcicosis of sturgeon comprises the following components: immunopotentiator, vitamin C, three-yellow powder, streptococcal agent and florfenicol;
the immunopotentiator is allicin;
the mass ratio of the streptogramins to the florfenicol is 6-8: 2-4; the mass ratio of the immunopotentiator to the vitamin C to the three-yellow powder is 10-15: 1-2: 4-8;
the traditional Chinese medicine raw materials of the three-yellow powder consist of rhubarb, scutellaria and phellodendron and are from conventional markets.
2. Use of a composition according to claim 1 for the manufacture of a medicament for the prophylaxis and treatment of streptococcicosis in sturgeon, wherein said use comprises prophylaxis and treatment;
the prevention comprises the steps of carrying out first disinfection on the net cage and carrying out second disinfection on sturgeon fries;
the treatment comprises feeding with immunopotentiator, vitamin C, SANHUANG powder, streptococcal agent and florfenicol; the feeding comprises the following steps: the mixture of the streptomycin and the florfenicol is fed, 6-8 days are taken as a treatment course, 2-4 treatment courses are fed, the interval between every two treatment courses is 6-8 days, and 6-8 days of the interval between every two treatment courses are fed with an immunopotentiator, vitamin C and tribasic yellow powder.
3. Use according to claim 2, wherein the disinfectant used for the first disinfection comprises an iodine preparation and/or chlorine dioxide.
4. The use according to claim 3, wherein the iodine formulation is used in an amount of 200-300 mL per acre per meter of water depth; the dosage of the chlorine dioxide is 2-4 g/m3。
5. The use according to claim 2, wherein the disinfectant used for the second disinfection comprises an aqueous solution of povidone-iodine or glutaraldehyde; the concentration of the povidone iodine is 45-55 ppm; the concentration of the glutaraldehyde water solution is 25-35 ppm.
6. Use according to claim 2, wherein the second sterilization takes place for a period of 3 to 5 min.
7. The use of claim 2, wherein the immunopotentiator, vitamin C and tribasic yellow powder are fed in a form of dressing; the weight ratio of the immunopotentiator to the feed is 10-15: 1000; the weight ratio of the vitamin C to the feed is 1-2: 1000; the weight ratio of the three-yellow powder to the feed is 4-8: 1000.
8. The use of claim 7, wherein the feeding times of the streptogramin and the florfenicol are 1-3 times per day; the total feeding amount of the streptomycin and the florfenicol is 0.12-0.15 g per kilogram of fish bodies.
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| CN102640722A (en) * | 2012-05-18 | 2012-08-22 | 湛江师范学院 | Control method of sepia streptococcicosis |
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| CN102640722A (en) * | 2012-05-18 | 2012-08-22 | 湛江师范学院 | Control method of sepia streptococcicosis |
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