CN107812002A - It is a kind of to be used for ornamental fish bacterium, virus, the medicine of parasite complex treatment - Google Patents
It is a kind of to be used for ornamental fish bacterium, virus, the medicine of parasite complex treatment Download PDFInfo
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- CN107812002A CN107812002A CN201711188875.9A CN201711188875A CN107812002A CN 107812002 A CN107812002 A CN 107812002A CN 201711188875 A CN201711188875 A CN 201711188875A CN 107812002 A CN107812002 A CN 107812002A
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- medicine
- dimetridazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Farming Of Fish And Shellfish (AREA)
Abstract
The invention discloses it is a kind of for ornamental fish bacterium, virus, parasite complex treatment medicine, belong to fish field of pharmaceutical technology.The product of the present invention is by levamisole hydrochloride, praziquantel, Dimetridazole or Dimetridazole derivative are as main ingredient composition, it wherein the ratio of each component is 60 80 parts of Dimetridazole or Dimetridazole derivative, 15 25 parts of levamisole hydrochloride, 8 12 parts of praziquantel, the parts by weight of Dimetridazole or Dimetridazole derivative for Dimetridazole weight grade in proportion, and tablet can according to circumstances be made, pulvis or liquid preparation, the medicine of the present invention is to flagellate, capillaria, roundworm, hookworm, the eliminating fish parasites such as tapeworm have killing effect, and there is killing action to anaerobic bacterias such as staphylococcus anaerobiuses, retain nitrobacteria simultaneously, fish growth can be promoted, improve fish resistance against diseases, do not influence water quality simultaneously.
Description
Technical field
The present invention relates to fish field of pharmaceutical technology, and in particular to one kind is used for ornamental fish bacterium, virus, parasite synthesis
The medicine for the treatment of.
Background technology
With the development of society, the living standard of people is gradually stepping up, also increasingly focus on the enjoyment of spirit level, see
Reward fish and aquarium have been increasingly becoming people and have been placed in ornamental article new in family, office, market.Ornamental fish is by its institute
Little in Spatial General 6 R, water source mobility is relatively small, and the generation for causing fish disease is easier if without changing in time.View and admire
Fish in breeding process inevitably by from feed, feeding environment, the bacterium only carried with cylinder other fishes, virus and
Parasitic infection, infected fish only not only lose ornamental value even death, economic loss are brought to culturist.Either family
Front yard, enterprise's culture of ornamental fish or intensive culture of ornamental fish field, raising water body will be much smaller with respect to aquaculture, mainly according to
Purified water by the nitrobacteria in circulated filter system.There has been no a kind of medicine in the market to ensure ornamental fish peace
Properly settled while complete and effectively kill epizoa in Fish, wide spectrum killing harmful bacteria, lifting fish anti-virus ability, together
When again do not damage nitrobacteria beneficial in aquarium.And culture of ornamental fish person does not possess the pharmacology knowledge of specialty mostly, such as
Fruit drug abuse is treated, and is not only difficult to suit the remedy to the case, it is easier to nitrobacteria is accidentally injured because of inappropriate medication, destroys cultivation water
The ecological balance of body, causes water quality deterioration, makes ornamental fish aggravation.
For this present invention propose it is a kind of for ornamental fish bacterium, virus, parasite complex treatment medicine, it is above-mentioned to solve
The problem of being mentioned in background technology.
The content of the invention
In view of the above-mentioned problems of the prior art, present invention offer is a kind of comprehensive for ornamental fish bacterium, virus, parasite
The medicine for the treatment of is closed, the medicine is with thin to that will not damage nitrification while epizoa in treatment fish body and bacterium infection
Bacterium, there is safe efficient, comprehensive therapeutic action.
To achieve these goals, the present invention is a kind of is used for ornamental fish bacterium, virus, the medicine of parasite complex treatment,
Component in the medicine includes levamisole hydrochloride, praziquantel, Dimetridazole or Dimetridazole derivative, the diformazan
Nitre imidazoles or Dimetridazole derivative, levamisole hydrochloride, praziquantel mix the main ingredient as medicine；
The weight proportion of the main ingredient each several part is：Dimetridazole or Dimetridazole derivative 60-80 parts, a hydrochloric acid left side
The parts by weight of rotation imidazoles 15-25 parts, praziquantel 8-12 parts, Dimetridazole or Dimetridazole derivative are Dimetridazole
In proportion, Dimetridazole or Dimetridazole derivative can effectively kill the fishes such as flagellate, trichomonad only internal original to the grade of weight
Raw parasite, and it is sterilized fungicidal spectrum and mainly covers anaerobic bacteria, has good treatment to fish In vivo infection caused by anaerobic bacteria
Imitate, and effectively prevent manslaughtering for the nitrobacteria in aquarium, in addition Dimetridazole or Dimetridazole derivative pair
Also promote ornamental fish growth and the gorgeous effect of body colour, levamisole hydrochloride can effectively drive away ascarifuge in fish enteron aisle and
Hookworm.Real levamisole hydrochloride has the function that promote fish immunity function to be favorably improved fish feels to bacterium and virus simultaneously
The resistance of dye, there is the effect of preferable for the vermin such as fish fluke and Dactylogyrus, Gyrodactylus and large-scale parasite.
Specifically, the composition in the medicine also includes pregelatinized starch, the medicine is left by Dimetridazole, hydrochloric acid
Rotation imidazoles, praziquantel, pregelatinized starch cross after 100 mesh sieves the pulvis mixed.
Specifically, the mass ratio of pregelatinized starch is 80%-90% in the medicine.
Specifically, the medicine is liquid preparation, and solution is pure water, and the main ingredient is by levamisole hydrochloride, pyrrole quinoline
Ketone, Dimetridazole Hydrochloride composition, and main ingredient concentration is 1%-5%.
Specifically, the composition in the medicine also includes water-solubleazone, and content of the water-solubleazone in medicine is
2ppm。
Specifically, the medicine is tablet, and the composition in the medicine also includes microcrystalline cellulose, and crystallite is fine in medicine
The mass ratio of dimension element is 70%-90%.
The beneficial effects of the invention are as follows：Dimetridazole, levamisole hydrochloride, pyrrole quinoline are included in the drug formulation of the present invention
Ketone, available for treatment flagellate, the fish such as trichomonad only internal protozoan parasite, drive away ascarifuge in fish enteron aisle and hookworm and
There is the effect of very strong to fish fluke and Dactylogyrus, in addition fungicidal spectrum of the invention mainly covers anaerobic bacteria, due to nitre
It is aerobic bacteria to change bacterium, so will not be manslaughtered to the nitrobacteria in aquarium, has certain targeting, in addition originally
Pulvis, tablet, liquid preparation can also be made to adapt to different demands in medicine according to actual conditions, in that context it may be convenient to quantitatively make
With can effectively be treated in ornamental fish body by the combination of main ingredient Dimetridazole or derivatives thereof, levamisole hydrochloride, praziquantel
Epizoa and bacterium infection, improve the resistance against diseases of ornamental fish.
Embodiment
With reference to specific embodiment, the invention will be further described, it is clear that described embodiment is only this hair
Bright part of the embodiment, rather than whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art are not having
There is the every other embodiment made and obtained under the premise of creative work, belong to the scope of protection of the invention.
Embodiment 1
A kind of to be used for ornamental fish bacterium, virus, the medicine of parasite complex treatment, its main ingredient is the group of following weight proportion
It is grouped into：By 60 parts of Dimetridazole, 15 parts of levamisole hydrochloride, 348 parts of processes 100 of 12 parts of praziquantel and pregelatinized starch
Purpose is sieved, and is mixed and made into pulvis, pregelatinized starch is easy to control the dosage of this medicine as diluent.
There is the phenomenon that a large amount of fancy carp food rations decline, vigor declines in Xuzhou fancy carp plant, in October, 2016,
Change a variety of feeds and lose improvement of ingesting, white purulence shape thing occurs in excrement, and infection visible peristalsis visible intestinal peristalsis point-like gas list is determined to feces examination
Born of the same parents bacterium, using manufactured pulvis in embodiment 1, is handled plant, sows this pulvis 50g's according to per cubic meter of water
Dosage, carry out full cylinder and splash, once, after repeating above-mentioned dosage and operating 6 days, the symptom of fish only, which has, substantially to be changed for addition in every 48 hours
Kind, fish excrement shaping, appetite is recovered, and the feces examination to fancy carp confirms that inflammation eliminates.
Embodiment 2
A kind of to be used for ornamental fish bacterium, virus, the medicine of parasite complex treatment, its main ingredient is the group of following weight proportion
It is grouped into：70 parts of Dimetridazole Hydrochloride, 20 parts of levamisole hydrochloride, 10 parts of praziquantel, due to the solubility of Dimetridazole
It is relatively low to be not easy that liquid preparation is made, therefore replaced using Dimetridazole Hydrochloride, above-mentioned medicine is mixed and is dissolved in 4900 parts pure
In water, add 0.01 part of water-solubleazone and liquid preparation is made, wherein water-solubleazone is to oleophylic, hydrophilic medicament and activity
Composition have it is obvious it is transdermal help oozing effect, make keratoderma and lipid interaction, reduce active principle to cuticula
The phase inversion temperature of lipid, adds mobility in gap, subtracts the diffusional resistance of medicine or active additive in cuticula
It is few, therefore the effect of oozing of very strong rush is played, absorption of the fish to medicine can be promoted, so as to increase effect.
Yancheng, Jiangsu Province ray fish culture field, introduce the wild import imperial crown black and white ray fish 13 of Brazil, raising one in July, 2016
Find that fish state is bad all the time after individual month, food refusal also occur with original ray fish in pond, get rid of head, stick up phenomena such as mouth, suspect wild
Raw fish carries pathogen, causes to infect.Dissection microscopy is only carried out to fish to find to have infected Hexamita, capillaria in vivo；The cheek
Portion infects Dactylogyrus, by liquid preparation made of embodiment 2, the ratio of 1L liquid preparations is added with per cubic meter of water, to disease
Fish daily dipping 2-3 hours, taken an evident turn for the better after being used in conjunction 3 days, symptom substantially eliminates after 7 days.
Embodiment 3
A kind of to be used for ornamental fish bacterium, virus, the medicine of parasite complex treatment, its main ingredient is the group of following weight proportion
It is grouped into：80 parts of Dimetridazole, 25 parts of levamisole hydrochloride, 8 parts of praziquantel, in addition the microcrystalline cellulose with 452 parts mix,
The degree of polymerization from microcrystalline cellulose is 5000, and tablet, convenience in transport and carrying is made by tabletting.
Always there are fancy carp infection variola disease in Shandong fancy carp plant, annual the time when autumn turns into winter, and fish body surface grows white dot,
Fish body is rapidly become thin, final dead, only chemically examines the fish that dies of illness confirmation infection herpesviral.The plant chooses a fish within 2016
Pond is tested using medicine of the present invention, and from June, tablet that embodiment of splashing weekly 3 makes, the medication of wherein main ingredient is dense
It is 10ppm to spend for concentration, is occurred then using the test tank of the medicine of the present invention without variola disease, other untapped cultivation fish ponds
Fish only still fall ill.
In summary, the present invention can effectively kill Hexamita, capillaria, roundworm, hookworm, tapeworm, fluke, common
Eliminating fish parasites are thin to actinomyces necrophorus, clostruidium, staphylococcus anaerobius, intestines vibrios, treponema bacterium etc.
Bacterium, have and significantly inhibit effect, lift fish anti-virus ability, promotion fish growth, safe range is larger, in addition can be with
Retain the nitrobacteria to benefit, and a variety of formulations can be made according to actual conditions, convenient operation and use.
Although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of changes, modification can be carried out to these embodiments, replace without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (6)
1. a kind of be used for ornamental fish bacterium, virus, the medicine of parasite complex treatment, it is characterised in that：Group in the medicine
Dividing includes levamisole hydrochloride, praziquantel, Dimetridazole or Dimetridazole derivative, Dimetridazole or the diformazan nitre
Imdazole derivatives, levamisole hydrochloride, praziquantel mix the main ingredient as medicine；
The weight proportion of the main ingredient each component is：Dimetridazole or Dimetridazole derivative 60-80 parts, the left-handed miaow of hydrochloric acid
The parts by weight of azoles 15-25 parts, praziquantel 8-12 parts, Dimetridazole or Dimetridazole derivative are Dimetridazole weight
Grade in proportion.
It is 2. according to claim 1 a kind of for ornamental fish bacterium, virus, the medicine of parasite complex treatment, its feature
It is：Composition in the medicine also includes pregelatinized starch, and the medicine is by Dimetridazole, levamisole hydrochloride, pyrrole
Quinoline ketone, pregelatinized starch cross after 100 mesh sieves the pulvis mixed.
It is 3. according to claim 2 a kind of for ornamental fish bacterium, virus, the medicine of parasite complex treatment, its feature
It is：The mass ratio of pregelatinized starch is 80%-90% in the medicine.
It is 4. according to claim 1 a kind of for ornamental fish bacterium, virus, the medicine of parasite complex treatment, its feature
It is：The medicine is liquid preparation, and solution is pure water, and the main ingredient is by levamisole hydrochloride, praziquantel, hydrochloride
Nitre imidazoles forms, and main ingredient concentration is 1%-5%.
It is 5. according to claim 4 a kind of for ornamental fish bacterium, virus, the medicine of parasite complex treatment, its feature
It is：Composition in the medicine also includes water-solubleazone, and content of the water-solubleazone in medicine is 2ppm.
It is 6. according to claim 1 a kind of for ornamental fish bacterium, virus, the medicine of parasite complex treatment, its feature
It is：The medicine is tablet, and the composition in the medicine also includes microcrystalline cellulose, the quality of microcrystalline cellulose in medicine
Ratio is 70%-90%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711188875.9A CN107812002A (en) | 2017-11-24 | 2017-11-24 | It is a kind of to be used for ornamental fish bacterium, virus, the medicine of parasite complex treatment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711188875.9A CN107812002A (en) | 2017-11-24 | 2017-11-24 | It is a kind of to be used for ornamental fish bacterium, virus, the medicine of parasite complex treatment |
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| Publication Number | Publication Date |
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| CN107812002A true CN107812002A (en) | 2018-03-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201711188875.9A Pending CN107812002A (en) | 2017-11-24 | 2017-11-24 | It is a kind of to be used for ornamental fish bacterium, virus, the medicine of parasite complex treatment |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115887451A (en) * | 2023-01-05 | 2023-04-04 | 山东国邦药业有限公司 | Levamisole hydrochloride tablet and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1190002A (en) * | 1998-01-06 | 1998-08-12 | 周慧先 | Vermifuge composition for farm animal |
-
2017
- 2017-11-24 CN CN201711188875.9A patent/CN107812002A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1190002A (en) * | 1998-01-06 | 1998-08-12 | 周慧先 | Vermifuge composition for farm animal |
Non-Patent Citations (2)
| Title |
|---|
| 刘雅丹: "《五彩缤纷的热带观赏鱼》", 30 June 2010, 中国社会出版社 * |
| 蒋高中: "《观赏鱼病防治800问》", 30 April 2013, 安徽科学技术出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115887451A (en) * | 2023-01-05 | 2023-04-04 | 山东国邦药业有限公司 | Levamisole hydrochloride tablet and preparation method thereof |
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180320 |
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| RJ01 | Rejection of invention patent application after publication |