CN1190002A - Vermifuge composition for farm animal - Google Patents

Abstract

The vermifuge consists of starch, cane sugar, levorotatory iminazole, manganese stearate, talculm powder and pyridone. Through retarding the effect of enzyme inside verm body and interfering the metabolism of verm, the vermifuge can repel three kinds of verms, including cestode, fluke and nematode in animal body without toxic side effect, and it has high effect especially to blood fluke. The vermifuge is special effect one to pig, ox, chicken, duck and other farm animals.

Description

Poultry anthelmintic " anthelmintic is clear "

The present invention relates to a kind of composite medicine for animals, especially the poultry anthelmintic.

At present, anthelmintic is of a great variety on the market, a kind ofly can not drive the parasitic medicine of three major types (silk ribbon, suction, nematicide) in the most body simultaneously but see; And the medicine praziquantel of treatment schistosomicide, take to cattle by therapeutic dose after, side reaction appears in great majority: the lighter's diarrhoea, heavy then miscarriage even dead, for this reason, have to expensive human and material resources, financial resources are handled side reaction, what have reduces dosage in order to reduce side reaction, do not have therapeutical effect.Thus, brought difficulty, for the radical cure schistosomicide has increased difficulty to prevention and cure of schistosomiasis work.

The object of the present invention is to provide and a kind ofly can drive three major types parasitic worm in the most animal body, and side effect is minimum, it is effective and can alleviate or avoid the vermifuge composition for farm animal of side reaction especially to treat schistosomicide.

In order to achieve the above object, the invention provides following technical scheme: develop a kind of composite medicine, has the polypide of inhibition endoenzyme, disturb the effect of polypide homergy, can be made into powder, tablet or other dosage form, be made up of starch, sucrose, levamisole, magnesium stearate, Pulvis Talci, praziquantel, its weight percentage is: starch 8%～30%, sucrose 0.5%～4%, levamisole 10%～50%, magnesium stearate 0.4%～5%, Pulvis Talci 1%～10%, praziquantel 40%～80%.

In producing process of the present invention, at first batching is made wet granular: after starch gelatinization, add sucrose, levamisole, praziquantel, Pulvis Talci, dried starch successively, the limit edged stirs, and fully mixes thoroughly, by stainless steel sift (12 or 16 order), makes granule then; Oven dry again: the wet granular of making is tiled in the container, puts in the baking oven and dry, bake out temperature is 30 ℃～50 ℃; Tabletting then: after the granule of oven dry weighed, add magnesium stearate by prescription, compacting is tablet in flakes.

Compared with prior art, the present invention has following tangible advantage:

1, anthelminthic effect is good, no side effects.

The present invention is through for many years clinical practice, and poultry are once thrown clothes or mix and raise, and deworming rates 100% is driven clean rate more than 95%, does not see any toxicity and side effect.Poultry is very fast parasite removing after taking medicine, and pig, the cattle polypide of taking medicine in back 24 hours is discharged, and a general defecation just can all eject worm, and ascaris suums are in the intestinal disintegrate individually.

For example: with the prescription of embodiment 1, in the domestic animal that local peasant household raises, 60 of optional test pigs, 12 of cattle, 12 of contrast pigs, tablet weight is organized oral administration by per kilogram of body weight medication 30mg, 40mg, 50mg, 60mg, and the dispensing back observes feces and helminthology cuts open inspection method judgement curative effect and toxicity and side effect fully.12～18 hours discharge polypides after consequently pig, cattle are taken medicine, deworming rates reaches 90.0%, 30mg/kg group drives that clean rate is 84.6%, to drive clean rate be that 90.3%, 50～60mg group is driven clean rate and reached 99.4% to the 40mg/kg group, the pork chop worm is maximum 69, the insect that has is not also discharged, disintegrate in intestinal, contrast pig infection rate 87.7%, 26.6 of average infection intensities, what test beefsteak worm was many has 0.62 kilogram, mainly is front and back dish trematodiasiss.

Use the prescription of embodiment 4 for another example, in the poultry that local peasant household raises, optional test chicken 123 plumages, duck 152 plumages, contrast chicken 31 plumages, duck 20 plumages, tablet weight is by per kilogram of body weight 40mg, 50mg, 60mg, 70mg dispensing, (feed or mix and raise) dispensing back observes feces and helminthology cuts open inspection method judgement curative effect and toxicity fully, chicken, duck are discharged polypide after about 2 hours, deworming rates reaches 100%, and driving clean rate: 40mg/kg group is 78.7%, 50mg/kg organizes is 81.6%, 60mg/kg organizes is 93.4%, 70mg/kg organizes is 99.4%; Usually having cestode, trematodiasis, nematicide to exist simultaneously in the feces that the test chicken and duck is discharged, all is the worm that lives, and many have cestode more than 100, matched group chicken and duck infection rate 97.2%, 88.3 of average infection intensities.

After the anthelmintic of test poultry, the fur light, food consumption reduces, and the productivity improves, and former skinny pig as bavin, cattle looked plump and sturdy in 1～2 month, in all experimental animals, all do not see side reaction.

2, raw material is easy to get, and technology is simple, and is with low cost.

The present invention is raw materials used, has all easily bought on market, and preparing process is also very simple, and production cost is low, and flower pesticide of a pig anthelmintic takes 0.3～1.0 yuan, can reduce cost 15～30 yuan; The cattle anthelmintic can be saved 30～60 yuan of poultry can rise in value 5～8 yuan, more inexpensive than Ivomec, to drive entozoa effect bigger, and curative effect is wider.

Below the invention will be further described by specific embodiment:

Embodiment 1: at first batching is made wet granular: after getting starch 20 gram gelatinizings, add sucrose 2 grams, levamisole 15 grams, praziquantel 50 grams, Pulvis Talci 2 grams, dried starch 10 grams successively, the limit edged stirs, and fully mixes thoroughly, by stainless steel sift (12 or 16 order), make granule then; Oven dry again: the wet granular of making is tiled in the container, puts in the baking oven and dry, bake out temperature is 30 ℃～50 ℃; Tabletting then: after the granule of oven dry weighed, add 1 gram magnesium stearate, compacting is tablet in flakes.

In the present embodiment, the weight percentage of its each component of compositions is: starch 30%, sucrose 2%, levamisole 15%, magnesium stearate 1%, Pulvis Talci 2%, praziquantel 50%.

Embodiment 2～6: each component prescription of compositions is as table 1, and preparation method is with embodiment 1.

Embodiment 2,3,5,6 is used for clinical trial, and curative effect is seen before and stated.

Table 1 poultry anthelmintic " anthelmintic is clear " prescription (unit of weight: gram)

Embodiment	The sliding left pyrrole fat stone of the hard sugarcane that forms sediment revolves quinoline powder acid Icing Sugar miaow ketone magnesium azoles
		????1 ????2 ????8 ????4 ????5 ????6	??30????1??????2??????2????15?????50 ??8?????0.5????0.5????1????50?????40 ??8?????0.4????0.6????1????10?????80 ??10????5??????4??????1????20?????60 ??10????2??????3??????10???25?????50 ??20????3??????2??????5????20?????50

Claims (2)

1, a kind of poultry anthelmintic " anthelmintic is clear ", has the polypide of inhibition endoenzyme, disturb the effect of polypide homergy, can be made into powder, tablet or other dosage form, it is characterized in that being made up of starch, sucrose, levamisole, magnesium stearate, Pulvis Talci, praziquantel, its weight percentage is: starch 8%～30%, sucrose 0.5%～4%, levamisole 10%～50%, magnesium stearate 0.4%～5%, Pulvis Talci 1%～10%, praziquantel 40%～80%.

2, the method for preparing claim 1 anthelmintic tablet is characterized in that having following process:

(1) batching system wet granular: after starch gelatinization, add sucrose, levamisole, praziquantel, Pulvis Talci, dried starch successively, the limit edged stirs, and fully mixes thoroughly, then

(2) under 30 ℃～50 ℃ temperature, dry, then

(3) add magnesium stearate by prescription, be pressed into tablet.