CN101190197B - Praziquantel chewable tablets for dog or cat - Google Patents
Praziquantel chewable tablets for dog or cat Download PDFInfo
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- CN101190197B CN101190197B CN2006101297152A CN200610129715A CN101190197B CN 101190197 B CN101190197 B CN 101190197B CN 2006101297152 A CN2006101297152 A CN 2006101297152A CN 200610129715 A CN200610129715 A CN 200610129715A CN 101190197 B CN101190197 B CN 101190197B
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Abstract
The invention discloses a praziquantel chewable tablet used for dogs and cats. The invention overcomes the poor palatability defect of the existing tablet to promote the thorough chewing absorption by dogs and cats, so as to effectively guarantee the medicine-supply dose, to enhance the cure rate of diseases of dogs and cats and to reduce the medicine waste. The tablet of the invention comprises the following components represented by weight-percentage: 1 to 5 percent of aspartame; 20 to 30 percent of a mixture of oral dextrose and degreased milk powder; the ratio of 1:1 to 1:4 between the oral dextrose and degreased milk powder in the mixture; 40 to 60 percent of excipient; 0.5 to 1 percent of glidant and 30 to 50 percent of praziquantel.
Description
Technical field
The present invention relates to the preparation technique of veterinary drug, particularly relate to palatability that a kind of dog cat uses chewable tablet preferably.
Background technology
Raising pets has long history in China.Along with growth in the living standard, the quantity of famous and precious dog, cat house pet increases gradually, and pet owners is also more and more paid attention to the quality of life of house pet.The dog cat is a mammal, the common disease that oneself is also arranged, the treatment of dog cat disease at present are mainly based on intravenous drip and intramuscular injection, and this therapeutic scheme often needs to raise the master and treats for the house pet of oneself time of arranging out specially, and, often cause the prognosis mala of disease in case treatment is interrupted.If can make initiatively oral administration medicine of dog cat, will solve this a series of problem, but tablet for animals few in number in the market often be difficult to apply because of its palatability difference.
Summary of the invention
The inventor is at the physiological characteristics of dog cat, broken through the shortcoming of existing tablet palatability difference, developed the chewable tablet that is applicable to dog cat taste, can make it fully chew post-absorption, effectively raise medicine utilization rate, guaranteed dosage, improved the cure rate of dog cat disease.
The object of the present invention is to provide a kind of chewable tablet that is used for dog cat disease treatment, it has good palatability, advantage that curative effect is high.
The composition of tablet of the present invention comprises: represent to be respectively aspartame 1-5% with percentage by weight, oral glucose and defatted milk powder mixture 20～30%, the ratio 1 of oral glucose, defatted milk powder: 1-1: 4 in the mixture; Excipient 40%～60%, fluidizer 0.5-1%, praziquantel 30-50%.
Described excipient comprises starch, dextrin, Icing Sugar, calcium sulfate or their mixture.
Described fluidizer comprises magnesium stearate, Pulvis Talci, micropowder silica gel or their mixture.
In order to obtain better effect, preferred ingredient is: aspartame 1-5%, oral glucose and defatted milk powder mixture 20～30%, the ratio 1 of oral glucose, defatted milk powder: 1-1: 4 in the mixture; Starch 40%～60%, magnesium stearate 0.5-1%, praziquantel 30-50%.
More preferably: aspartame 2%, oral glucose and defatted milk powder mixture 20%, the ratio 1 of oral glucose, defatted milk powder: 1-1: 4 in the mixture; Starch 42.5%, magnesium stearate 0.5%, praziquantel 35%
Tablet of the present invention can adopt the general process of industry, equipment preparation.The following method preparation of preferred employing comprises step:
1) with starch in 100 ℃ of dryings 1 hour, be cooled to room temperature; Afterwards respectively with the excipient of praziquantel, aspartame and equivalent with equivalent progressively increase the dilution method dilution, mixes, mistake 60 order fine screens three times obtain mixture A;
2) with mixture A and remaining excipient, oral glucose, defatted milk powder mix homogeneously, mixture B is standby;
3) glycerol and dehydrated alcohol are pressed 1: the mixed of 5-10 is even, adds polyvinylpyrrolidone afterwards, makes polyvinylpyrrolidone glycerol alcohol mixed solution, as binding agent;
4) the polyvinylpyrrolidone glycerol alcohol mixed solution of its volume 1/2 of adding in mixture B, mix homogeneously is as soft material;
5) granulate with 16 mesh sieves, 50 ℃ of aeration-dryings get dried particles.Accurately take by weighing lubricant and join in the dried granules, mixing, with 18 mesh sieve granulate, tabletting is promptly.
Beneficial effect: tablet of the present invention has been broken the blank of field of veterinary chewable tablet, broken through the shortcoming of existing oral tablet palatability difference, physiological characteristics at the dog cat, develop the chewable tablet that is applicable to dog cat taste, making it chew the back fully absorbs, effectively raise the cure rate of disease, reduced the waste of medicine.
The specific embodiment
In order to understand the present invention, further specify the present invention with embodiment below, but do not limit the present invention.
Embodiment 1: Praziquantel chewable tablets
Get starch 2400g in 100 ℃ of bakings 1 hour, be cooled to room temperature; Other gets praziquantel 1800g, aspartame 60g, with cooled starch with equivalent progressively increase dilution method dilution, mixes, cross 60 orders afterwards, fine screen three times must mixture A.Mixture A and oral glucose 600g, defatted milk powder 600g and starch 540g are put into the mixer mix homogeneously, mixture B, standby.Glycerol and dehydrated alcohol are got 2.5L after by 1: 10 mixed, make polyvinylpyrrolidone glycerol alcohol mixed solution to wherein adding polyvinylpyrrolidone 200g.
Stir down that gradation adds polyvinylpyrrolidone glycerol alcohol mixed solution in mixture B, to all adding, mix homogeneously, soft material that humidity is moderate.16 mesh sieves are granulated, 50 ℃ of aeration-dryings.Accurately take by weighing magnesium stearate 60g and be added in the dried granules, mixing is with 18 mesh sieve granulate, tabletting.Film-making is about 10000 altogether, and every heavy 0.6g contains praziquantel 0.18g.
Tablet of the present invention is mainly used in dog cat schistosomicide, also is used for taeniasis and cysticercosis.For oral administration: as once to measure dog, cat 2.5-5mg.Do not recommend with praziquantel be used for 4 ages in week with interior pup and 6 ages in week with interior kitten, but have the product of praziquantel and febantel compatibility to can be used for the dog and the cat at various ages, also can be used safely in the dog and the cat of pregnancy.
Test example 1:
Experimental animal: choose 12 public dogs of health of the different cultivars of Tianjin suburban district Canis familiaris L. field, be 1 years old half to two years old, carry out palatability testing.
Trial drug: trial drug is a tablet of the present invention, the tablet that control drug is produced for certain animal pharmaceutical factory, and the content specification is 0.2g.
Content of the test: 12 dogs are divided into two groups at random, test group and matched group, the test group tablet of the present invention of feeding, 1 of average every dog; The control drug of control group fed isodose, the palatability difference of observing both.
Result of the test: by being observed, the desire of searching for food of test dog finds that the test dog has the hope of well searching for food to preparation of the present invention, can be with the tablet eat everything up of being fed, opposite control drug is not tested dog and is ready to eat because palatability is relatively poor.
Can find that by this test tablet of the present invention has good palatability, feeding gets final product in the process of administration, makes its sick dog free choice feeding can reach the purpose of curing the disease.
Embodiment 2: Praziquantel chewable tablets
Get starch 2280g, praziquantel 2100g, aspartame 120g makes mixture A by embodiment 1 described method.
Mixture A and oral glucose 375g, defatted milk powder 1125g and starch 270g are put into the mixer mix homogeneously, mixture B, standby.Glycerol and dehydrated alcohol are got 2.5L by 1: 5 mixed after evenly, make polyvinylpyrrolidone glycerol alcohol mixed solution and make binding agent to wherein adding polyvinylpyrrolidone 200g.
Stir down that gradation adds polyvinylpyrrolidone glycerol alcohol mixed solution in mixture B, to all adding, mix homogeneously, soft material that humidity is moderate.Accurately take by weighing magnesium stearate 30g granulate, press embodiment 1 described method granulation, drying, granulate, tabletting.Film-making is about 10000 altogether, and every heavy 0.6g contains praziquantel 0.21g.
Embodiment 3: Praziquantel chewable tablets
Get starch 3300g, praziquantel 3000g, aspartame 300g, make mixture A by embodiment 1 described method.Mixture A and oral glucose 300g, defatted milk powder 900g and starch 300g are put into the mixer mix homogeneously, mixture B, standby.Glycerol and dehydrated alcohol are got 2.5L by 1: 10 mixed after evenly, make polyvinylpyrrolidone glycerol alcohol mixed solution and make binding agent to wherein adding polyvinylpyrrolidone 200g.
Stir down that gradation adds polyvinylpyrrolidone glycerol alcohol mixed solution in mixture B, to all adding, mix homogeneously, soft material that humidity is moderate.Accurately take by weighing magnesium stearate 30g granulate, press embodiment 1 described method granulation, drying, granulate, tabletting.Film-making is about 10000 altogether, and every heavy 0.6g contains praziquantel 0.3g.
Claims (3)
1. Praziquantel chewable tablets for dog or cat agent, it is characterized in that component and percentage by weight are: aspartame 1～5%, excipient 40%～60%, fluidizer 0.5～1%, praziquantel 30～50%, oral glucose and defatted milk powder mixture 20～30%, the ratio of mixture is: oral glucose: defatted milk powder=1: 1～1: 4, described excipient is starch, dextrin, Icing Sugar, calcium sulfate or their mixture, and described fluidizer is magnesium stearate, Pulvis Talci, micropowder silica gel or their mixture; The percentage by weight sum of described each component is 100%.
2. according to the described Praziquantel chewable tablets for dog or cat agent of claim 1, it is characterized in that component and percentage by weight are: aspartame 1～5%, starch 40%～60%, magnesium stearate 0.5～1%, praziquantel 30～50%, oral glucose and defatted milk powder mixture 20～30%, the ratio of oral glucose, defatted milk powder in the mixture=1: 1～1: 4; The percentage by weight sum of described each component is 100%.
3. according to the described Praziquantel chewable tablets for dog or cat agent of claim 1, it is characterized in that component and percentage by weight are: aspartame 2%, starch 42.5%, magnesium stearate 0.5%, praziquantel 35%, oral glucose and defatted milk powder mixture 20%, the ratio of mixture is: oral glucose: defatted milk powder=1: 1～1: 4.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006101297152A CN101190197B (en) | 2006-11-29 | 2006-11-29 | Praziquantel chewable tablets for dog or cat |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006101297152A CN101190197B (en) | 2006-11-29 | 2006-11-29 | Praziquantel chewable tablets for dog or cat |
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| Publication Number | Publication Date |
|---|---|
| CN101190197A CN101190197A (en) | 2008-06-04 |
| CN101190197B true CN101190197B (en) | 2010-10-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2006101297152A Active CN101190197B (en) | 2006-11-29 | 2006-11-29 | Praziquantel chewable tablets for dog or cat |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107157944A (en) * | 2017-05-24 | 2017-09-15 | 武威牛满加药业有限责任公司 | A kind of expelling parasite tablet for animals containing phagostimulant |
| CN107519169A (en) * | 2017-09-14 | 2017-12-29 | 中国疾病预防控制中心寄生虫病预防控制所 | A kind of composition for driving away echinococcus for canid and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1190002A (en) * | 1998-01-06 | 1998-08-12 | 周慧先 | Vermifuge composition for farm animal |
| CN1408352A (en) * | 2002-09-20 | 2003-04-09 | 单玉华 | Formula of iron-compensating agent chewing tablet |
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2006
- 2006-11-29 CN CN2006101297152A patent/CN101190197B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1190002A (en) * | 1998-01-06 | 1998-08-12 | 周慧先 | Vermifuge composition for farm animal |
| CN1408352A (en) * | 2002-09-20 | 2003-04-09 | 单玉华 | Formula of iron-compensating agent chewing tablet |
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| CN101190197A (en) | 2008-06-04 |
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| ASS | Succession or assignment of patent right |
Owner name: RUIPU ( TIANJIN ) BIOLOGICAL MEDICINE INDUSTRY CO. Free format text: FORMER OWNER: TIANJIN CITY RUNTUO BIOISYSTECH CO., LTD. Effective date: 20090731 |
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| C41 | Transfer of patent application or patent right or utility model | ||
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Effective date of registration: 20090731 Address after: Tianjin City, six Dongli Road Development Zone No. 6 Applicant after: Ruipu (Tianjin) Biological Pharmaceutical Co., Ltd. Address before: Tianjin City, six Dongli Road Development Zone No. 6 Applicant before: Tianjin Ringtop Biotechnology Co., Ltd. |
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