CN101190203A - Atropine sulfate chewable tablets for dog or cat - Google Patents
Atropine sulfate chewable tablets for dog or cat Download PDFInfo
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- CN101190203A CN101190203A CNA2006101297379A CN200610129737A CN101190203A CN 101190203 A CN101190203 A CN 101190203A CN A2006101297379 A CNA2006101297379 A CN A2006101297379A CN 200610129737 A CN200610129737 A CN 200610129737A CN 101190203 A CN101190203 A CN 101190203A
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- atropine sulfate
- oral glucose
- defatted milk
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Abstract
The invention discloses an atropine sulfate chewable tablet used for dogs and cats. The invention can overcome the disadvantage of the poor palatability of the existing tablets, promote dogs and cats to chew and adsorb fully, effectively ensure the dosage of administration, enhance the cure rate of feline or canine diseases and reduce the waste of medicine. The tablet of the invention includes the following components represented by weight-percentage respectively: 1-5 percent of aspartame, 20-30 percent of the mixture of oral glucose and skim milk powder, in which the ratio of oral glucose and skim milk powder is 1:1-1:4, 40-60 percent of excipient, 0.5-1 percent of glidant and 5-20 percent of atropine sulfate.
Description
Technical field
The present invention relates to the preparation technique of veterinary drug, particularly relate to palatability that a kind of dog cat uses chewable tablet preferably.
Background technology
Raising pets has long history in China.Along with growth in the living standard, the quantity of famous and precious dog, cat house pet increases gradually, and pet owners is also more and more paid attention to the quality of life of house pet.The dog cat is a mammal, the common disease that oneself is also arranged, the treatment of dog cat disease at present are mainly based on intravenous drip and intramuscular injection, and this therapeutic scheme often needs to raise the master and treats for the house pet of oneself time of arranging out specially, and, often cause the prognosis mala of disease in case treatment is interrupted.If can make initiatively oral administration medicine of dog cat, will solve this a series of problem, but tablet for animals few in number in the market often be difficult to apply because of its palatability difference.
Summary of the invention
The inventor is at the physiological characteristics of dog cat, broken through the shortcoming of existing tablet palatability difference, developed the chewable tablet that is applicable to dog cat taste, can make it fully chew post-absorption, effectively raise medicine utilization rate, guaranteed dosage, improved the cure rate of dog cat disease.
The object of the present invention is to provide a kind of chewable tablet that is used for dog cat disease treatment, it has good palatability, advantage that curative effect is high.
The composition of tablet of the present invention comprises: represent to be respectively aspartame 1-5% with percentage by weight, oral glucose and defatted milk powder mixture 20～30%, the ratio 1 of oral glucose, defatted milk powder: 1-1: 4 in the mixture; Excipient 40%～60%, fluidizer 0.5-1%, atropine sulfate 5～20%.
Described excipient comprises starch, dextrin, Icing Sugar, calcium sulfate or their mixture.
Described fluidizer comprises magnesium stearate, Pulvis Talci, micropowder silica gel or their mixture.
In order to obtain better effect, preferred ingredient is: aspartame 1-5%, oral glucose and defatted milk powder mixture 20～30%, the ratio 1 of oral glucose, defatted milk powder: 1-1: 4 in the mixture; Starch 40%～60%, magnesium stearate 0.5-1%, atropine sulfate 5～20%.
More preferably: aspartame 3.5%, oral glucose and defatted milk powder mixture 20%, the ratio 1 of oral glucose, defatted milk powder: 1-1: 4 in the mixture; Starch 60%, magnesium stearate 0.5%, atropine sulfate 16%
Tablet of the present invention can adopt the general process of industry, equipment preparation.The following method preparation of preferred employing comprises step:
1) with starch in 100 ℃ of dryings 1 hour, be cooled to room temperature; Afterwards respectively with atropine sulfate, aspartame and equivalent excipient with equivalent progressively increase the dilution method dilution, mixes, mistake 60 order fine screens three times obtain mixture A;
2) with mixture A and remaining excipient, oral glucose, defatted milk powder mix homogeneously, mixture B is standby;
3) glycerol and dehydrated alcohol are pressed 1: the mixed of 5-10 is even, adds polyvinylpyrrolidone afterwards, makes polyvinylpyrrolidone glycerol alcohol mixed solution, as binding agent;
4) the polyvinylpyrrolidone glycerol alcohol mixed solution of its volume 1/2 of adding in mixture B, mix homogeneously is as soft material;
5) granulate with 16 mesh sieves, 50 ℃ of aeration-dryings get dried particles.Accurately take by weighing lubricant and join in the dried granules, mixing, with 18 mesh sieve granulate, tabletting is promptly.
Beneficial effect: tablet of the present invention has been broken the blank of field of veterinary chewable tablet, broken through the shortcoming of existing oral tablet palatability difference, physiological characteristics at the dog cat, develop the chewable tablet that is applicable to dog cat taste, making it chew the back fully absorbs, effectively raise the cure rate of disease, reduced the waste of medicine.
The specific embodiment
In order to understand the present invention, further specify the present invention with embodiment below, but do not limit the present invention.
Embodiment 1: Atropine sulfate chewable tablets
Get starch 2400g in 100 ℃ of bakings 1 hour, be cooled to room temperature; Other gets atropine sulfate 300g, aspartame 60g, with cooled starch with equivalent progressively increase dilution method dilution, mixes, cross 60 orders afterwards, fine screen three times must mixture A.Mixture A and oral glucose 600g, defatted milk powder 600g and starch 2040g are put into the mixer mix homogeneously, mixture B, standby.Glycerol and dehydrated alcohol are got 2.5L after by 1: 10 mixed, make polyvinylpyrrolidone glycerol alcohol mixed solution to wherein adding polyvinylpyrrolidone 200g.
Stir down that gradation adds polyvinylpyrrolidone glycerol alcohol mixed solution in mixture B, to all adding, mix homogeneously, soft material that humidity is moderate.16 mesh sieves are granulated, 50 ℃ of aeration-dryings.Accurately take by weighing magnesium stearate 60g and be added in the dried granules, mixing is with 18 mesh sieve granulate, tabletting.Film-making is about 10000 altogether, every heavy 0.6g, sulfur acid atropine 0.05g.
Tablet of the present invention is mainly used in gastrointestinal smooth muscle spasm, sialism, organophosphate poisoning etc.For oral administration: as once to measure every 1kg body weight, dog, cat 0.02-0.04mg.
Attention: intestinal obstruction, urine retention etc. are suffered from the poultry forbidding; Poison and save the supportive and symptomatic treatment of appropriate to the occasion employing, can try out medicines antagonism such as physostigmine, fugitive barbiturates, chloral hydrate when being on wires.Forbidding phenothiazines medicine such as Post-treatment of Chlorpromazine.
Test example 1:
Experimental animal: choose 12 public dogs of health of the different cultivars of Tianjin suburban district Canis familiaris L. field, be 1 years old half to two years old, carry out palatability testing.
Trial drug: trial drug is a tablet of the present invention, the tablet that control drug is produced for certain animal pharmaceutical factory, and the content specification is 0.05g.
Content of the test: 12 dogs are divided into two groups at random, test group and matched group, the test group tablet of the present invention of feeding, 1 of average every dog; The control drug of control group fed isodose, the palatability difference of observing both.
Result of the test: by being observed, the desire of searching for food of test dog finds that the test dog has the hope of well searching for food to preparation of the present invention, can be with the tablet eat everything up of being fed, opposite control drug is not tested dog and is ready to eat because palatability is relatively poor.
Can find that by this test tablet of the present invention has good palatability, feeding gets final product in the process of administration, makes its sick dog free choice feeding can reach the purpose of curing the disease.
Embodiment 2: Atropine sulfate chewable tablets
Get starch 1170g, atropine sulfate 960g, aspartame 210g makes mixture A by embodiment 1 described method.
Mixture A and oral glucose 375g, defatted milk powder 1125g and starch 2430g are put into the mixer mix homogeneously, mixture B, standby.Glycerol and dehydrated alcohol are got 2.5L by 1: 5 mixed after evenly, make polyvinylpyrrolidone glycerol alcohol mixed solution and make binding agent to wherein adding polyvinylpyrrolidone 200g.
Stir down that gradation adds polyvinylpyrrolidone glycerol alcohol mixed solution in mixture B, to all adding, mix homogeneously, soft material that humidity is moderate.Accurately take by weighing magnesium stearate 30g granulate, press embodiment 1 described method granulation, drying, granulate, tabletting.Film-making is about 10000 altogether, every heavy 0.6g, sulfur acid atropine 0.096g.
Embodiment 3: Atropine sulfate chewable tablets
Get starch 1500g, atropine sulfate 1200, aspartame 300g, make mixture A by embodiment 1 described method.Mixture A and oral glucose 360g, defatted milk powder 1440g and starch 2100g are put into the mixer mix homogeneously, mixture B, standby.Glycerol and dehydrated alcohol are got 2.5L by 1: 10 mixed after evenly, make polyvinylpyrrolidone glycerol alcohol mixed solution and make binding agent to wherein adding polyvinylpyrrolidone 200g.
Stir down that gradation adds polyvinylpyrrolidone glycerol alcohol mixed solution in mixture B, to all adding, mix homogeneously, soft material that humidity is moderate.Accurately take by weighing magnesium stearate 30g granulate, press embodiment 1 described method granulation, drying, granulate, tabletting.Film-making is about 10000 altogether, every heavy 0.6g, sulfur acid atropine 0.18g.
Claims (4)
1. Atropine sulfate chewable tablets for dog or cat agent, it is characterized in that component and percentage by weight are: aspartame 1～5%, excipient 40%～60%, fluidizer 0.5～1%, atropine sulfate 5～20%, oral glucose and defatted milk powder mixture 20～30%, the ratio of mixture is: oral glucose: defatted milk powder=1: 1～1: 4.
Described excipient is starch, dextrin, Icing Sugar, calcium sulfate or their mixture.
Described fluidizer is magnesium stearate, Pulvis Talci, micropowder silica gel or their mixture.
2. according to the described Atropine sulfate chewable tablets for dog or cat agent of claim 1, it is characterized in that component and percentage by weight are: aspartame 1～5%, starch 40%～60%, magnesium stearate 0.5～1%, atropine sulfate 5～20%, oral glucose and defatted milk powder mixture 20～30%, the ratio of oral glucose, defatted milk powder in the mixture=1: 1～1: 4.
3. according to the described Atropine sulfate chewable tablets for dog or cat agent of claim 1, it is characterized in that component and percentage by weight are: aspartame 3.5%, starch 60%, magnesium stearate 0.5%, atropine sulfate 16%, oral glucose and defatted milk powder mixture 20%, the ratio of mixture is: oral glucose: defatted milk powder=1: 1～1: 4.
4. according to the preparation method of the described tablet of claim 1, it is characterized in that comprising step:
1) with starch in 100 ℃ of dryings 1 hour, be cooled to room temperature; Afterwards respectively with atropine sulfate, aspartame and equivalent excipient with equivalent progressively increase the dilution method dilution, mixes, mistake 60 order fine screens three times obtain mixture A;
2) with mixture A and remaining excipient, oral glucose, defatted milk powder mix homogeneously, mixture B is standby;
3) glycerol and dehydrated alcohol are pressed 1: the mixed of 5-10 is even, adds polyvinylpyrrolidone afterwards, makes polyvinylpyrrolidone glycerol alcohol mixed solution, as binding agent;
4) the polyvinylpyrrolidone glycerol alcohol mixed solution of its volume 1/2 of adding in mixture B, mix homogeneously is as soft material;
5) granulate with 16 mesh sieves, 50 ℃ of aeration-dryings get dried particles.The fluidizer that accurately takes by weighing recipe quantity joins in the dried granules, mixing, and with 18 mesh sieve granulate, tabletting is promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101297379A CN101190203A (en) | 2006-11-29 | 2006-11-29 | Atropine sulfate chewable tablets for dog or cat |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101297379A CN101190203A (en) | 2006-11-29 | 2006-11-29 | Atropine sulfate chewable tablets for dog or cat |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101190203A true CN101190203A (en) | 2008-06-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006101297379A Pending CN101190203A (en) | 2006-11-29 | 2006-11-29 | Atropine sulfate chewable tablets for dog or cat |
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| Country | Link |
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| CN (1) | CN101190203A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973629A (en) * | 2012-10-31 | 2013-03-20 | 河南牧翔动物药业有限公司 | Oral liquid for preventing and treating intestinal diseases of livestock and poultry and preparation method thereof |
| CN107648184A (en) * | 2017-11-23 | 2018-02-02 | 铜陵市东方矿冶机械有限责任公司 | Atropine sulfate is scattered and preparation method thereof again |
-
2006
- 2006-11-29 CN CNA2006101297379A patent/CN101190203A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973629A (en) * | 2012-10-31 | 2013-03-20 | 河南牧翔动物药业有限公司 | Oral liquid for preventing and treating intestinal diseases of livestock and poultry and preparation method thereof |
| CN102973629B (en) * | 2012-10-31 | 2014-10-22 | 河南牧翔动物药业有限公司 | Oral liquid for preventing and treating intestinal diseases of livestock and poultry and preparation method thereof |
| CN107648184A (en) * | 2017-11-23 | 2018-02-02 | 铜陵市东方矿冶机械有限责任公司 | Atropine sulfate is scattered and preparation method thereof again |
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Open date: 20080604 |