CN101190201A - Folic acid chewable tablets for dog or cat - Google Patents
Folic acid chewable tablets for dog or cat Download PDFInfo
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- CN101190201A CN101190201A CNA2006101297311A CN200610129731A CN101190201A CN 101190201 A CN101190201 A CN 101190201A CN A2006101297311 A CNA2006101297311 A CN A2006101297311A CN 200610129731 A CN200610129731 A CN 200610129731A CN 101190201 A CN101190201 A CN 101190201A
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- folic acid
- milk powder
- oral glucose
- defatted milk
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Abstract
The invention discloses a folic acid chewable tablet used for dogs and cats. The invention can overcome the disadvantage of the poor palatability of the existing tablets, promote dogs and cats to chew and adsorb fully, effectively ensure the dosage of administration, enhance the cure rate of feline or canine diseases and reduce the waste of medicine. The tablet of the invention includes the following components represented by weight-percentage respectively: 1-5 percent of aspartame, 20-30 percent of the mixture of oral glucose and skim milk powder, in which the ratio of oral glucose and skim milk powder is 1:1-1:4, 40-60 percent of excipient, 0.5-1 percent of glidant and 10-30 percent of folic acid.
Description
Technical field
The present invention relates to the preparation technique of veterinary drug, particularly relate to palatability that a kind of dog cat uses chewable tablet preferably.
Background technology
Raising pets has long history in China.Along with growth in the living standard, the quantity of famous and precious dog, cat house pet increases gradually, and pet owners is also more and more paid attention to the quality of life of house pet.The dog cat is a mammal, the common disease that oneself is also arranged, the treatment of dog cat disease at present are mainly based on intravenous drip and intramuscular injection, and this therapeutic scheme often needs to raise the master and treats for the house pet of oneself time of arranging out specially, and, often cause the prognosis mala of disease in case treatment is interrupted.If can make initiatively oral administration medicine of dog cat, will solve this a series of problem, but tablet for animals few in number in the market often be difficult to apply because of its palatability difference.
Summary of the invention
The inventor is at the physiological characteristics of dog cat, broken through the shortcoming of existing tablet palatability difference, developed the chewable tablet that is applicable to dog cat taste, can make it fully chew post-absorption, effectively raise medicine utilization rate, guaranteed dosage, improved the cure rate of dog cat disease.
The object of the present invention is to provide a kind of folic acid chewable tablets agent that is used for dog cat disease treatment, it has good palatability, advantage that curative effect is high.
The object of the present invention is to provide a kind of folic acid chewable tablets agent that is used for dog cat disease treatment, it has good palatability, advantage that curative effect is high.
The composition of tablet of the present invention comprises: represent to be respectively aspartame 1-5% with percentage by weight, oral glucose and defatted milk powder mixture 20～30%, the ratio 1 of oral glucose, defatted milk powder: 1-1: 4 in the mixture; Excipient 40%～60%, fluidizer 0.5-1%, folic acid 10～30%.
Described excipient comprises starch, dextrin, Icing Sugar, calcium sulfate or their mixture.
Described fluidizer comprises magnesium stearate, Pulvis Talci, micropowder silica gel or their mixture.
In order to obtain better effect, preferred ingredient is: aspartame 1-5%, oral glucose and defatted milk powder mixture 20～30%, the ratio 1 of oral glucose, defatted milk powder: 1-1: 4 in the mixture; Starch 40%～60%, magnesium stearate 0.5-1%, folic acid 10～30%.
More preferably: aspartame 3.5%, oral glucose and defatted milk powder mixture 20%, the ratio 1 of oral glucose, defatted milk powder: 1-1: 4 in the mixture; Starch 56%, magnesium stearate 0.5%, folic acid 20%
Tablet of the present invention can adopt the preparation technique and the equipment preparation of industry routine.The following method preparation of preferred employing comprises step:
1) with starch in 100 ℃ of dryings 1 hour, be cooled to room temperature; Afterwards respectively with the excipient of folic acid, aspartame and equivalent with equivalent progressively increase the dilution method dilution, mixes, mistake 60 order fine screens three times obtain mixture A;
2) with mixture A and remaining excipient, oral glucose, defatted milk powder mix homogeneously, mixture B is standby;
3) will add polyvinylpyrrolidone in the dehydrated alcohol, make the polyvinylpyrrolidone alcohol mixed solution, as binding agent;
4) the polyvinylpyrrolidone alcohol mixed solution of its volume 1/2 of adding in mixture B, mix homogeneously is as soft material;
5) granulate with 16 mesh sieves, 50 ℃ of aeration-dryings get dried particles.Accurately take by weighing lubricant and join in the dried granules, mixing, with 18 mesh sieve granulate, tabletting is promptly.
Beneficial effect: tablet of the present invention has been broken the blank of field of veterinary chewable tablet, broken through the shortcoming of existing oral tablet palatability difference, physiological characteristics at the dog cat, develop the chewable tablet that is applicable to dog cat taste, making it chew the back fully absorbs, effectively raise the cure rate of disease, reduced the waste of medicine.
The specific embodiment
In order to understand the present invention, further specify the present invention with embodiment below, but do not limit the present invention.
Embodiment 1: folic acid chewable tablets
Get starch 2400g in 100 ℃ of bakings 1 hour, be cooled to room temperature; Other gets folic acid 600g, aspartame 60g, with cooled starch with equivalent progressively increase dilution method dilution, mixes, cross 60 orders afterwards, fine screen three times must mixture A.Mixture A and oral glucose 600g, defatted milk powder 600g and starch 1740g are put into the mixer mix homogeneously, mixture B, standby.Dehydrated alcohol is got 2.5L, make the polyvinylpyrrolidone alcohol mixed solution to wherein adding polyvinylpyrrolidone 200g.
Stir down that gradation adds the polyvinylpyrrolidone alcohol mixed solution in mixture B, to all adding, mix homogeneously, soft material that humidity is moderate.16 mesh sieves are granulated, 50 ℃ of aeration-dryings.Accurately take by weighing magnesium stearate 30g and be added in the dried granules, mixing is with 18 mesh sieve granulate, tabletting.Film-making is about 10000 altogether, and every heavy 0.6g contains folic acid 0.06g.
Tablet of the present invention is mainly used in dog, the cat anemia that control causes because of folic acid deficiency.For oral administration: as once to measure dog, cat 2.5-5mg.
Test example 1:
Experimental animal: choose 12 public dogs of health of the different cultivars of Tianjin suburban district Canis familiaris L. field, be 1 years old half to two years old, carry out palatability testing.
Trial drug: trial drug is a tablet of the present invention, and control drug is the tablet that Tianjin animal pharmaceutical factory produces, and the content specification is 0.06g.
Content of the test: 12 dogs are divided into two groups at random, test group and matched group, the test group tablet of the present invention of feeding, 1 of average every dog; The control drug of control group fed isodose, the palatability difference of observing both.
Result of the test: by being observed, the desire of searching for food of test dog finds that the test dog has the hope of well searching for food to preparation of the present invention, can be with the tablet eat everything up of being fed, opposite control drug is not tested dog and is ready to eat because palatability is relatively poor.
Can find that by this test tablet of the present invention has good palatability, feeding gets final product in the process of administration, makes its sick dog free choice feeding can reach the purpose of curing the disease.
Embodiment 2: folic acid chewable tablets
Get starch 1410g, folic acid 1200g, aspartame 210g makes mixture A by embodiment 1 described method.
Mixture A and oral glucose 375g, defatted milk powder 1125g and starch 1950g are put into the mixer mix homogeneously, mixture B, standby.Dehydrated alcohol is got 2.5L, make the polyvinylpyrrolidone alcohol mixed solution and make binding agent to wherein adding polyvinylpyrrolidone 200g.
Stir down that gradation adds the polyvinylpyrrolidone alcohol mixed solution in mixture B, to all adding, mix homogeneously, soft material that humidity is moderate.Accurately take by weighing magnesium stearate 30g granulate, press embodiment 1 described method granulation, drying, granulate, tabletting.Film-making is 10000 approximately, and every heavy 0.6g contains folic acid 0.12g.
Embodiment 3: folic acid chewable tablets
Get starch 2100g, folic acid 1800g, aspartame 300g, make mixture A by embodiment 1 described method.Mixture A and oral glucose 360g, defatted milk powder 1440g and starch 1500g are put into the mixer mix homogeneously, mixture B, standby.Dehydrated alcohol is got 2.5L, make the polyvinylpyrrolidone alcohol mixed solution and make binding agent to wherein adding polyvinylpyrrolidone 200g.
Stir down that gradation adds the polyvinylpyrrolidone alcohol mixed solution in mixture B, to all adding, mix homogeneously, soft material that humidity is moderate.Accurately take by weighing magnesium stearate 30g granulate, press embodiment 1 described method granulation, drying, granulate, tabletting.10000 of about altogether film-makings, every heavy 0.6g contains folic acid 0.18g.
Claims (4)
1. folic acid chewable tablets for dog or cat agent, it is characterized in that component and percentage by weight are: aspartame 1～5%, excipient 40%～60%, fluidizer 0.5～1%, folic acid 10-30%, oral glucose and defatted milk powder mixture 20～30%, the ratio of mixture is: oral glucose: defatted milk powder=1: 1～1: 4.
Described excipient is starch, dextrin, Icing Sugar, calcium sulfate or their mixture.
Described fluidizer is magnesium stearate, Pulvis Talci, micropowder silica gel or their mixture.
2. according to the described folic acid chewable tablets for dog or cat agent of claim 1, it is characterized in that component and percentage by weight are: aspartame 1～5%, starch 40%～60%, magnesium stearate 0.5～1%, folic acid 10-30%, oral glucose and defatted milk powder mixture 20～30%, the ratio of oral glucose, defatted milk powder in the mixture=1: 1～1: 4.
3. according to the described folic acid chewable tablets for dog or cat agent of claim 1, it is characterized in that component and percentage by weight are: aspartame 3.5%, starch 56%, magnesium stearate 0.5%, folic acid 20%, oral glucose and defatted milk powder mixture 20%, the ratio of mixture is: oral glucose: defatted milk powder=1: 1～1: 4.
4. according to the preparation method of the described tablet of claim 1, it is characterized in that comprising step:
1) with starch in 100 ℃ of dryings 1 hour, be cooled to room temperature; Afterwards respectively with folic acid, aspartame and equivalent excipient with equivalent progressively increase the dilution method dilution, mixes, mistake 60 order fine screens three times obtain mixture A;
2) with mixture A and remaining excipient, oral glucose, defatted milk powder mix homogeneously, mixture B is standby;
3) glycerol and dehydrated alcohol are pressed 1: the mixed of 5-10 is even, adds polyvinylpyrrolidone afterwards, makes polyvinylpyrrolidone glycerol alcohol mixed solution, as binding agent;
4) the polyvinylpyrrolidone glycerol alcohol mixed solution of its volume 1/2 of adding in mixture B, mix homogeneously is as soft material;
5) granulate with 16 mesh sieves, 50 ℃ of aeration-dryings get dried particles.The fluidizer that accurately takes by weighing recipe quantity joins in the dried granules, mixing, and with 18 mesh sieve granulate, tabletting is promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101297311A CN101190201A (en) | 2006-11-29 | 2006-11-29 | Folic acid chewable tablets for dog or cat |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101297311A CN101190201A (en) | 2006-11-29 | 2006-11-29 | Folic acid chewable tablets for dog or cat |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101190201A true CN101190201A (en) | 2008-06-04 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006101297311A Pending CN101190201A (en) | 2006-11-29 | 2006-11-29 | Folic acid chewable tablets for dog or cat |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101190201A (en) |
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2006
- 2006-11-29 CN CNA2006101297311A patent/CN101190201A/en active Pending
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| C06 | Publication | ||
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20080604 |