CN101190216A - Noramidopyrine chewable tablets for dog or cat - Google Patents

Abstract

The invention discloses an analgin chewable tablet used for dogs and cats. The invention overcomes the poor palatability defect of the existing tablet to promote the thorough chewing absorption by dogs and cats, so as to effectively guarantee the medicine-supply dose, to enhance the cure rate of diseases of dogs and cats and to reduce the medicine waste. The tablet of the invention comprises the following components represented by weight-percentage: 1 to 5 percent of aspartame; 20 to 30 percent of a mixture of oral dextrose and degreased milk powder; the ratio of 1:1 to 1:4 between the oral dextrose and degreased milk powder in the mixture; 40 to 60 percent of excipient; 0.5 to 1 percent of glidant and 30 to 50 percent of analgin.

Description

A kind of Noramidopyrine chewable tablets for dog or cat

Technical field

The present invention relates to the preparation technique of veterinary drug, particularly relate to palatability that a kind of dog cat uses chewable tablet preferably.

Background technology

Raising pets has long history in China.Along with growth in the living standard, the quantity of famous and precious dog, cat house pet increases gradually, and pet owners is also more and more paid attention to the quality of life of house pet.The dog cat is a mammal, the common disease that oneself is also arranged, the treatment of dog cat disease at present are mainly based on intravenous drip and intramuscular injection, and this therapeutic scheme often needs to raise the master and treats for the house pet of oneself time of arranging out specially, and, often cause the prognosis mala of disease in case treatment is interrupted.If can make initiatively oral administration medicine of dog cat, will solve this a series of problem, but tablet for animals few in number in the market often be difficult to apply because of its palatability difference.

Summary of the invention

The inventor is at the physiological characteristics of dog cat, broken through the shortcoming of existing tablet palatability difference, developed the chewable tablet that is applicable to dog cat taste, can make it fully chew post-absorption, effectively raise medicine utilization rate, guaranteed dosage, improved the cure rate of dog cat disease.

The object of the present invention is to provide a kind of chewable tablet that is used for dog cat disease treatment, it has good palatability, advantage that curative effect is high.

The composition of tablet of the present invention comprises: represent to be respectively aspartame 1-5% with percentage by weight, oral glucose and defatted milk powder mixture 20～30%, the ratio 1 of oral glucose, defatted milk powder: 1-1: 4 in the mixture; Excipient 40%～60%, fluidizer 0.5-1%, dipyrone 30-50%.

Described excipient comprises starch, dextrin, Icing Sugar, calcium sulfate or their mixture.

Described fluidizer comprises magnesium stearate, Pulvis Talci, micropowder silica gel or their mixture.

In order to obtain better effect, preferred ingredient is: aspartame 1-5%, oral glucose and defatted milk powder mixture 20～30%, the ratio 1 of oral glucose, defatted milk powder: 1-1: 4 in the mixture; Starch 40%～60%, magnesium stearate 0.5-1%, dipyrone 30-50%.

More preferably: aspartame 3%, oral glucose and defatted milk powder mixture 20%, the ratio 1 of oral glucose, defatted milk powder: 1-1: 4 in the mixture; Starch 40%, magnesium stearate 0.5%, dipyrone 36.5%.

Tablet of the present invention can adopt the general process of industry, equipment preparation.The following method preparation of preferred employing comprises step:

1) with starch in 100 ℃ of dryings 1 hour, be cooled to room temperature; Afterwards respectively with the excipient of dipyrone, aspartame and equivalent with equivalent progressively increase the dilution method dilution, mixes, mistake 60 order fine screens three times obtain mixture A;

2) with mixture A and remaining excipient, oral glucose, defatted milk powder mix homogeneously, mixture B is standby;

3) glycerol and dehydrated alcohol are pressed 1: the mixed of 5-10 is even, adds polyvinylpyrrolidone afterwards, makes polyvinylpyrrolidone glycerol alcohol mixed solution, as binding agent;

4) the polyvinylpyrrolidone glycerol alcohol mixed solution of its volume 1/2 of adding in mixture B, mix homogeneously is as soft material;

5) granulate with 16 mesh sieves, 50 ℃ of aeration-dryings get dried particles.Accurately take by weighing lubricant and join in the dried granules, mixing, with 18 mesh sieve granulate, tabletting is promptly.

Beneficial effect: tablet of the present invention has been broken the blank of field of veterinary chewable tablet, broken through the shortcoming of existing oral tablet palatability difference, physiological characteristics at the dog cat, develop the chewable tablet that is applicable to dog cat taste, making it chew the back fully absorbs, effectively raise the cure rate of disease, reduced the waste of medicine.

The specific embodiment

In order to understand the present invention, further specify the present invention with embodiment below, but do not limit the present invention.

Embodiment 1: Noramidopyrine chewable tablets

Get starch 2400g in 100 ℃ of bakings 1 hour, be cooled to room temperature; Other gets dipyrone 1800g, aspartame 60g, with cooled starch with equivalent progressively increase dilution method dilution, mixes, cross 60 orders afterwards, fine screen three times must mixture A.Mixture A and oral glucose 600g, defatted milk powder 600g and starch 540g are put into the mixer mix homogeneously, mixture B, standby.Glycerol and dehydrated alcohol are got 2.5L after by 1: 10 mixed, make polyvinylpyrrolidone glycerol alcohol mixed solution to wherein adding polyvinylpyrrolidone 200g.

Stir down that gradation adds polyvinylpyrrolidone glycerol alcohol mixed solution in mixture B, to all adding, mix homogeneously, soft material that humidity is moderate.16 mesh sieves are granulated, 50 ℃ of aeration-dryings.Accurately take by weighing magnesium stearate 60g and be added in the dried granules, mixing is with 18 mesh sieve granulate, tabletting.Film-making is about 10000 altogether, and every heavy 0.6g contains dipyrone 0.18g.

Tablet of the present invention is mainly used in myalgia, rheumatism, heat generation illness and colic etc.For oral administration: as once to measure dog 0.5-1g.

Test example 1:

Experimental animal: choose 12 public dogs of health of the different cultivars of Tianjin suburban district Canis familiaris L. field, be 1 years old half to two years old, carry out palatability testing.

Trial drug: trial drug is a tablet of the present invention, and control drug is the tablet that Shandong animal pharmaceutical factory produces, and the content specification is 0.3g.

Content of the test: 12 dogs are divided into two groups at random, test group and matched group, the test group tablet of the present invention of feeding, 1 of average every dog; The control drug of control group fed isodose, the palatability difference of observing both.

Result of the test: by being observed, the desire of searching for food of test dog finds that the test dog has the hope of well searching for food to preparation of the present invention, can be with the tablet eat everything up of being fed, opposite control drug is not tested dog and is ready to eat because palatability is relatively poor.

Can find that by this test tablet of the present invention has good palatability, feeding gets final product in the process of administration, makes its sick dog free choice feeding can reach the purpose of curing the disease.

Embodiment 2: Noramidopyrine chewable tablets

Get starch 2400g, dipyrone 2190g, aspartame 180g makes mixture A by embodiment 1 described method.

Mixture A and oral glucose 375g, defatted milk powder 1125g and starch 30g are put into the mixer mix homogeneously, mixture B, standby.Glycerol and dehydrated alcohol are got 2.5L by 1: 5 mixed after evenly, make polyvinylpyrrolidone glycerol alcohol mixed solution and make binding agent to wherein adding polyvinylpyrrolidone 200g.

Stir down that gradation adds polyvinylpyrrolidone glycerol alcohol mixed solution in mixture B, to all adding, mix homogeneously, soft material that humidity is moderate.Accurately take by weighing magnesium stearate 30g granulate, press embodiment 1 described method granulation, drying, granulate, tabletting.Film-making is about 10000 altogether, and every heavy 0.6g contains the about 0.22g of dipyrone.

Embodiment 3: Noramidopyrine chewable tablets

Get starch 3300g, dipyrone 3000g, aspartame 300g, make mixture A by embodiment 1 described method.Mixture A and oral glucose 360g, defatted milk powder 1440g and starch 300g are put into the mixer mix homogeneously, mixture B, standby.Glycerol and dehydrated alcohol are got 2.5L by 1: 10 mixed after evenly, make polyvinylpyrrolidone glycerol alcohol mixed solution and make binding agent to wherein adding polyvinylpyrrolidone 200g.

Stir down that gradation adds polyvinylpyrrolidone glycerol alcohol mixed solution in mixture B, to all adding, mix homogeneously, soft material that humidity is moderate.Accurately take by weighing magnesium stearate 30g granulate, press embodiment 1 described method granulation, drying, granulate, tabletting.Film-making is about 10000 altogether, and every heavy 0.6g contains dipyrone 0.3g.

Claims (4)

1. Noramidopyrine chewable tablets for dog or cat agent, it is characterized in that component and percentage by weight are: aspartame 1～5%, excipient 40%～60%, fluidizer 0.5～1%, dipyrone 30～50%, oral glucose and defatted milk powder mixture 20～30%, the ratio of mixture is: oral glucose: defatted milk powder=1: 1～1: 4.

Described excipient is starch, dextrin, Icing Sugar, calcium sulfate or their mixture.

Described fluidizer is magnesium stearate, Pulvis Talci, micropowder silica gel or their mixture.

2. according to the described Noramidopyrine chewable tablets for dog or cat agent of claim 1, it is characterized in that component and percentage by weight are: aspartame 1～5%, starch 40%～60%, magnesium stearate 0.5～1%, dipyrone 30～50%, oral glucose and defatted milk powder mixture 20～30%, the ratio of oral glucose, defatted milk powder in the mixture=1: 1～1: 4.

3. according to the described Noramidopyrine chewable tablets for dog or cat agent of claim 1, it is characterized in that component and percentage by weight are: aspartame 3%, starch 40%, magnesium stearate 0.5%, dipyrone 36.5%, oral glucose and defatted milk powder mixture 20%, the ratio of mixture is: oral glucose: defatted milk powder=1: 1～1: 4.

4. according to the preparation method of the described tablet of claim 1, it is characterized in that comprising step:

1) with starch in 100 ℃ of dryings 1 hour, be cooled to room temperature; Afterwards respectively with dipyrone, aspartame and equivalent excipient with equivalent progressively increase the dilution method dilution, mixes, mistake 60 order fine screens three times obtain mixture A;

2) with mixture A and remaining excipient, oral glucose, defatted milk powder mix homogeneously, mixture B is standby;

3) glycerol and dehydrated alcohol are pressed 1: the mixed of 5-10 is even, adds polyvinylpyrrolidone afterwards, makes polyvinylpyrrolidone glycerol alcohol mixed solution, as binding agent;

4) the polyvinylpyrrolidone glycerol alcohol mixed solution of its volume 1/2 of adding in mixture B, mix homogeneously is as soft material;

5) granulate with 16 mesh sieves, 50 ℃ of aeration-dryings get dried particles.The fluidizer that accurately takes by weighing recipe quantity joins in the dried granules, mixing, and with 18 mesh sieve granulate, tabletting is promptly.