CN102973629B - Oral liquid for preventing and treating intestinal diseases of livestock and poultry and preparation method thereof - Google Patents
Oral liquid for preventing and treating intestinal diseases of livestock and poultry and preparation method thereof Download PDFInfo
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- 239000007788 liquid Substances 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 244000144977 poultry Species 0.000 title claims abstract description 15
- 244000144972 livestock Species 0.000 title claims abstract description 12
- 208000028774 intestinal disease Diseases 0.000 title abstract 2
- 239000000284 extract Substances 0.000 claims abstract description 39
- 239000003814 drug Substances 0.000 claims abstract description 25
- 229920001661 Chitosan Polymers 0.000 claims abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 238000000605 extraction Methods 0.000 claims abstract description 19
- 229940079593 drug Drugs 0.000 claims abstract description 16
- 238000005189 flocculation Methods 0.000 claims abstract description 12
- 230000016615 flocculation Effects 0.000 claims abstract description 12
- 238000010438 heat treatment Methods 0.000 claims abstract description 12
- 239000012535 impurity Substances 0.000 claims abstract description 12
- 238000010992 reflux Methods 0.000 claims abstract description 12
- 239000006228 supernatant Substances 0.000 claims abstract description 12
- 229930003347 Atropine Natural products 0.000 claims abstract description 11
- VKJGBAJNNALVAV-UHFFFAOYSA-M Berberine chloride (TN) Chemical compound [Cl-].C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 VKJGBAJNNALVAV-UHFFFAOYSA-M 0.000 claims abstract description 11
- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 claims abstract description 11
- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 claims abstract description 11
- 229960000396 atropine Drugs 0.000 claims abstract description 11
- 239000012141 concentrate Substances 0.000 claims abstract description 5
- 238000002791 soaking Methods 0.000 claims abstract description 5
- 230000000968 intestinal effect Effects 0.000 claims description 12
- 230000002421 anti-septic effect Effects 0.000 claims description 10
- 201000010099 disease Diseases 0.000 claims description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- 239000003381 stabilizer Substances 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 7
- 239000004299 sodium benzoate Substances 0.000 claims description 7
- 235000010234 sodium benzoate Nutrition 0.000 claims description 7
- 229920001285 xanthan gum Polymers 0.000 claims description 7
- 239000000230 xanthan gum Substances 0.000 claims description 7
- 229940082509 xanthan gum Drugs 0.000 claims description 7
- 235000010493 xanthan gum Nutrition 0.000 claims description 7
- 238000007789 sealing Methods 0.000 claims description 5
- 230000001954 sterilising effect Effects 0.000 claims description 5
- 239000002671 adjuvant Substances 0.000 claims description 3
- 239000004615 ingredient Substances 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 2
- 241000287828 Gallus gallus Species 0.000 abstract description 14
- 150000001875 compounds Chemical class 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 4
- 230000008901 benefit Effects 0.000 abstract description 3
- 239000000273 veterinary drug Substances 0.000 abstract description 3
- 208000001848 dysentery Diseases 0.000 abstract description 2
- 239000000203 mixture Substances 0.000 abstract description 2
- 229940067866 dandelion extract Drugs 0.000 abstract 6
- 235000020691 dandelion extract Nutrition 0.000 abstract 6
- 239000001845 taraxacum officinale leaf extract Substances 0.000 abstract 6
- 229940126678 chinese medicines Drugs 0.000 abstract 3
- 229940126673 western medicines Drugs 0.000 abstract 3
- 238000009833 condensation Methods 0.000 abstract 2
- 230000005494 condensation Effects 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 241000245665 Taraxacum Species 0.000 abstract 1
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 abstract 1
- 238000005119 centrifugation Methods 0.000 abstract 1
- 239000000306 component Substances 0.000 abstract 1
- 230000003467 diminishing effect Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000005426 pharmaceutical component Substances 0.000 abstract 1
- 230000000576 supplementary effect Effects 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 235000013330 chicken meat Nutrition 0.000 description 9
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 8
- 210000003608 fece Anatomy 0.000 description 8
- 235000013594 poultry meat Nutrition 0.000 description 7
- 229960000583 acetic acid Drugs 0.000 description 4
- 238000007796 conventional method Methods 0.000 description 4
- 239000012362 glacial acetic acid Substances 0.000 description 4
- 206010059866 Drug resistance Diseases 0.000 description 3
- 102000002322 Egg Proteins Human genes 0.000 description 3
- 108010000912 Egg Proteins Proteins 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 210000004681 ovum Anatomy 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- 230000003068 static effect Effects 0.000 description 3
- SPFYMRJSYKOXGV-UHFFFAOYSA-N Baytril Chemical compound C1CN(CC)CCN1C(C(=C1)F)=CC2=C1C(=O)C(C(O)=O)=CN2C1CC1 SPFYMRJSYKOXGV-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 229960000740 enrofloxacin Drugs 0.000 description 2
- 235000021050 feed intake Nutrition 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 230000003340 mental effect Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 240000000233 Melia azedarach Species 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 239000003640 drug residue Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229940124307 fluoroquinolone Drugs 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 206010034754 petechiae Diseases 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 235000020989 red meat Nutrition 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry
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- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The invention discloses an oral liquid for preventing and treating intestinal diseases of livestock and poultry and a preparation method thereof, belonging to the technical field of veterinary drugs. Each 100 ml of the oral liquid contains the following effective components: 4.0 to 8.0 g of berberine hydrochloride, 90 to 96 ml of dandelion extract and 0.03 to 0.05 g of atropine. The dandelion extract is prepared through the following steps: soaking dandelion with water, carrying out heating reflux extraction twice, combining two liquid extracts, carrying out condensation, then adding 15 to 30 ml of a chitosan solution with a concentration of 0.5 to 2% into each 100 ml of a concentrate and successively carrying out flocculation for removal of impurities, centrifugation of a supernatant and condensation so as to obtain the dandelion extract. Each 1 ml of the dandelion extract is equal to 0.8 to 1.2 g of a crude drug. The oral liquid provided by the invention is a compound preparation of Chinese and western medicines; the dandelion extract, berberine hydrochloride and atropine are all used as pharmaceutical components, and through complex formulation of the Chinese and western medicines, the dandelion extract, berberine hydrochloride and atropine exert supplementary and synergistic effects to fully perform the advantages of the Chinese and western medicines; and the oral liquid has the efficacy of pain easing, inflammation diminishing, dysentery treating and the like. In use, each 100 ml of the oral liquid is mixed with 100 kg of water, livestock and poultry can be healed after taking the oral liquid for 2 to 3 days, and the advantages of a substantial effect and uneasy recurrence are obtained; and the oral liquid is applicable to exported chicken farms.
Description
Technical field
The invention belongs to veterinary drug technical field, relate to a kind of oral liquid of preventing and treating livestock and poultry intestinal canal diseases and preparation method thereof.
Background technology
In recent years, along with antibiotic a large amount of uses, particularly in growth of animals or poultry widely, not scientific and normally abuse of antibiotics, its drawback is also subject to people's attention day by day.The problem such as bacterial drug resistance and drug residue, is not only directly involved in the problem that poultry can be used without medicine, more relates to the mankind's health, so antibacterials, and the exploitation of especially anti-intestinal medicine is the Research Emphasis of each veterinary drug enterprises always.
Summary of the invention
The object of the present invention is to provide oral liquid of a kind of evident in efficacy, control livestock and poultry intestinal canal diseases of be difficult for producing drug resistance and preparation method thereof.The commodity that the applicant drafts oral liquid of the present invention are called: compound recipe connects the two clear oral liquids in Pu.
For achieving the above object, the technical scheme that the present invention takes is as follows:
Prevent and treat an oral liquid for livestock and poultry intestinal canal diseases, in every 100ml oral liquid, its effective ingredient is: berberine hydrochloride 4.0 ~ 8.0g, Herba Taraxaci extract 90 ~ 96ml, atropine 0.03 ~ 0.05g; Wherein Herba Taraxaci extract obtains by the following method: after getting Herba Taraxaci and soaking, heating and refluxing extraction secondary, merge extracted twice liquid, concentrated, then in every 100ml concentrated solution, add 0.5 ~ 2% chitosan solution of 15 ~ 30ml, after flocculation remove impurity, centrifugalize supernatant, concentrate and obtain Herba Taraxaci extract, every 1ml Herba Taraxaci extract is equivalent to crude drug 0.8 ~ 1.2g.
Preferably, Herba Taraxaci extract obtains by the following method: get 100g Herba Taraxaci and soak after 1 ~ 2h, heating and refluxing extraction secondary, each extraction adds water 500 ~ 1000ml, 1 ~ 2h for the first time, 0.5 ~ 1.5h, merges extracted twice liquid for the second time, 60 ~ 70 ℃ are concentrated into 400 ~ 600ml, then in every 100ml concentrated solution, add 0.5 ~ 2% chitosan solution of 15 ~ 30ml, after flocculation remove impurity, centrifugalize supernatant, be concentrated into 100ml and obtain Herba Taraxaci extract, every 1ml Herba Taraxaci extract is equivalent to crude drug 1g.
For increasing antiseptic property and the stability of oral liquid, in every 100ml oral liquid, contain adjuvant: antiseptic 0.2 ~ 0.3g, stabilizing agent 0.05 ~ 0.2g.
Further, described antiseptic is preferably sodium benzoate, and described stabilizing agent is preferably xanthan gum.
Preparation method, comprises the following steps:
(1), after getting Herba Taraxaci and soaking, heating and refluxing extraction secondary, merge extracted twice liquid, concentrated, then in every 100ml concentrated solution, add 0.5 ~ 2% chitosan solution of 15 ~ 30ml, after flocculation remove impurity, centrifugalize supernatant, concentrate and obtain Herba Taraxaci extract, every 1ml Herba Taraxaci extract is equivalent to crude drug 0.8 ~ 1.2g.
(2) get Herba Taraxaci extract 90 ~ 96ml that step (1) makes, add respectively 4.0 ~ 8.0g berberine hydrochloride, 0.03 ~ 0.05g atropine, stir, the pH value of adjusting solution is 5.0 ~ 7.0, then water is settled to 100ml, filtration, fill, sealing, sterilizing.
Preferably, Herba Taraxaci extract obtains by the following method: get 100g Herba Taraxaci and soak after 1 ~ 2h, heating and refluxing extraction secondary, each extraction adds water 500 ~ 1000ml, 1 ~ 2h for the first time, 0.5 ~ 1.5h, merges extracted twice liquid for the second time, 60 ~ 70 ℃ are concentrated into 400 ~ 600ml, then in every 100ml concentrated solution, add 0.5 ~ 2% chitosan solution of 15 ~ 30ml, after flocculation remove impurity, centrifugalize supernatant, be concentrated into 100ml and obtain Herba Taraxaci extract, every 1ml Herba Taraxaci extract is equivalent to crude drug 1g.
For increasing antiseptic property and the stability of oral liquid, in step (2), in Herba Taraxaci extract, add have 0.2 ~ 0.3g antiseptic, 0.05 ~ 0.2g stabilizing agent.Described antiseptic is preferably sodium benzoate, and described stabilizing agent is preferably xanthan gum.
In the present invention, 0.5 ~ 2% chitosan solution is prepared according to a conventional method, specifically can be: (1) take 1g glacial acetic acid add in 100ml water prepare 1%(w/v) acetum; (2) take 0.5 ~ 2g chitosan and add 1%(w/v) acetum 100ml, be stirred to and dissolve preparation 0.5 ~ 2%(w/v) chitosan solution.
Compound recipe on existing market connects only applicable people of the two clear granules in Pu, and is not suitable for poultry.The applicant, connecting on the basis of the two clear granules in Pu, by process modification, adds suitable composition, has prepared the clear oral liquid of Lian Pushuan, evident in efficacy through clinical trial, for clinic control animal and bird intestines pathogenic infection provides a kind of feasible selection.
The present invention is Chinese medicine and western medicine compound preparation, take Herba Taraxaci extract, berberine hydrochloride and atropine to combine as ingredient, composite by Chinese medicine and western medicine, and three plays mutually auxiliary, and synergism, gives full play to Chinese medicine and western medicine advantage, has analgesia, antiinflammatory, controls the effects such as dysentery.During use, 100ml oral liquid adds 100 kg of water, takes and can fully recover for 2 ~ 3 days, and effect is remarkable, is difficult for recurrence, can be used for exporting chicken house.
The specific embodiment
Below in conjunction with specific embodiment, technical scheme of the present invention is done further and introduced in detail, but protection scope of the present invention is not limited to this.
Embodiment 1
(1) get 100g Herba Taraxaci and soak after 2h, heating and refluxing extraction secondary, each extraction adds water 500ml, 1.5h for the first time, 1h, merges extracted twice liquid for the second time, and 60 ℃ are concentrated into 500ml, then in every 100ml concentrated solution, add 1% chitosan solution of 15ml, slowly stir after 2min, after the static flocculation remove impurity of room temperature 24h, centrifugalize supernatant, be concentrated into 100ml and obtain Herba Taraxaci extract, every 1ml Herba Taraxaci extract is equivalent to crude drug 1g.Wherein, 1% chitosan solution is prepared according to a conventional method, specifically can be: (1) take 1g glacial acetic acid add in 100ml water prepare 1%(w/v) acetum; (2) take 1g chitosan and add 1%(w/v) acetum 100ml, be stirred to and dissolve preparation 1%(w/v) chitosan solution.
(2) get the Herba Taraxaci extract 90ml that step (1) makes, add respectively 0.20g sodium benzoate, 0.03g atropine, 4.0g berberine hydrochloride, 0.05g xanthan gum, stirring, (use hydrochloric acid or/and sodium hydroxide solution, below in like manner) PH of adjustment solution is 5.0, by purified water, be settled to 100ml, filter, be up to the standards, fill, sealing, sterilizing.
Embodiment 2
(1) get 100g Herba Taraxaci and soak after 1h, heating and refluxing extraction secondary, each extraction adds water 800ml, 1h for the first time, 0.5h, merges extracted twice liquid for the second time, and 65 ℃ are concentrated into 400ml, then in every 100ml concentrated solution, add 2% chitosan solution of 20ml, slowly stir after 2min, after the static flocculation remove impurity of room temperature 24h, centrifugalize supernatant, be concentrated into 125ml and obtain Herba Taraxaci extract, every 1ml Herba Taraxaci extract is equivalent to crude drug 0.8g.Wherein, 2% chitosan solution is prepared according to a conventional method, specifically can be: (1) take 1g glacial acetic acid add in 100ml water prepare 1%(w/v) acetum; (2) take 2g chitosan and add 1%(w/v) acetum 100ml, be stirred to and dissolve preparation 2%(w/v) chitosan solution.
(2) get the Herba Taraxaci extract 93ml that step (1) makes, add respectively 0.25g sodium benzoate, 0.04g atropine, 6.0g berberine hydrochloride, 0.10g xanthan gum, stir, the PH that adjusts solution is 6.0, by purified water, be settled to 100ml, filter, be up to the standards, fill, sealing, sterilizing.
Embodiment 3
(1) get 100g Herba Taraxaci and soak after 1.5h, heating and refluxing extraction secondary, each extraction adds water 1000ml, 2h for the first time, 1.5h, merges extracted twice liquid for the second time, and 70 ℃ are concentrated into 600ml, then in every 100ml concentrated solution, add 0.5% chitosan solution of 30ml, slowly stir after 2min, after the static flocculation remove impurity of room temperature 24h, centrifugalize supernatant, be concentrated into 83ml and obtain Herba Taraxaci extract, every 1ml Herba Taraxaci extract is equivalent to crude drug 1.2g.Wherein, 0.5% chitosan solution is prepared according to a conventional method, specifically can be: (1) take 1g glacial acetic acid add in 100ml water prepare 1%(w/v) acetum; (2) take 0.5g chitosan and add 1%(w/v) acetum 100ml, be stirred to and dissolve preparation 0.5%(w/v) chitosan solution.
(2) get the Herba Taraxaci extract 96ml that step (1) makes, add respectively 0.30g sodium benzoate, 0.05g atropine, 8.0g berberine hydrochloride, 0.20g xanthan gum, stir, the PH that adjusts solution is 7.0, by purified water, be settled to 100ml, filter, be up to the standards, fill, sealing, sterilizing.
clinic Case
Huozhou, Linfen, Shanxi Province chicken house, 25 Day-old Broiler Chickens, chicken group moisture in feces is high, and feedstuff sample feces accounts for 30%, and red meat sample feces accounts for 30% of normal feces, and feed intake declines serious, is fragmentary death.
Analyse symptom: intestinal wall attenuation, there is petechia, the bag heart and bag liver, indivedual serious chickens, intestinal tube swelling, has Radix Dauci Sativae sample feces in intestinal wall, be tentatively diagnosed as enteritis.
Administrated method: by the administration in two batches of sick chicken, first connects the two clear oral liquids in Pu (oral liquid of embodiment 1 preparation) drinking-water administration with compound recipe, and 100ml adds 100 kg of water, be used in conjunction 3 days, second batch gives 5%(quality) enrofloxacin soluble powder, 100g adds in 100 kg of water, is used in conjunction 3.
Curative effect feedback: the chicken group medication mental status on the same day that uses compound recipe to connect the two clear oral liquids in Pu is clearly better, and feed intake increases, medication the 2nd day, dead without Ovum Gallus domesticus, medication is after 3 days, and chicken group feces is normal, substantially gets well.With 5% enrofloxacin soluble powder group, medication 3 days, chicken group mental attitude is not improved, feces is without Radix Dauci Sativae sample feces, but still have a large amount of loose stools to occur, dead Ovum Gallus domesticus number, may be relevant to fluoroquinolone antibiotics generation drug resistance with this batch of Ovum Gallus domesticus without obvious reduction.The visible newly oral liquid of development is obviously better than traditional antibiotic medicine, and can be used for exporting chicken house.
Claims (8)
1. prevent and treat an oral liquid for livestock and poultry intestinal canal diseases, it is characterized in that in every 100ml oral liquid, its effective ingredient is: berberine hydrochloride 4.0 ~ 8.0g, Herba Taraxaci extract 90 ~ 96ml, atropine 0.03 ~ 0.05g; Wherein Herba Taraxaci extract obtains by the following method: after getting Herba Taraxaci and soaking, heating and refluxing extraction secondary, merge extracted twice liquid, concentrated, then in every 100ml concentrated solution, add 0.5 ~ 2% chitosan solution of 15 ~ 30ml, after flocculation remove impurity, centrifugalize supernatant, concentrate and obtain Herba Taraxaci extract, every 1ml Herba Taraxaci extract is equivalent to crude drug 0.8 ~ 1.2g.
2. the oral liquid of control livestock and poultry intestinal canal diseases as claimed in claim 1, it is characterized in that Herba Taraxaci extract obtains by the following method: get 100g Herba Taraxaci and soak after 1 ~ 2h, heating and refluxing extraction secondary, each extraction adds water 500 ~ 1000ml, 1 ~ 2h for the first time, 0.5 ~ 1.5h for the second time, merge extracted twice liquid, 60 ~ 70 ℃ are concentrated into 400 ~ 600ml, then in every 100ml concentrated solution, add 0.5 ~ 2% chitosan solution of 15 ~ 30ml, after flocculation remove impurity, centrifugalize supernatant, be concentrated into 100ml and obtain Herba Taraxaci extract, every 1ml Herba Taraxaci extract is equivalent to crude drug 1g.
3. the oral liquid of control livestock and poultry intestinal canal diseases as claimed in claim 1 or 2, is characterized in that in every 100ml oral liquid, its adjuvant is: antiseptic 0.2 ~ 0.3g, stabilizing agent 0.05 ~ 0.2g.
4. the oral liquid of control livestock and poultry intestinal canal diseases as claimed in claim 3, is characterized in that: described antiseptic is sodium benzoate, and described stabilizing agent is xanthan gum.
5. a method of preparing the oral liquid of preventing and treating livestock and poultry intestinal canal diseases, is characterized in that comprising the following steps:
(1), after getting Herba Taraxaci and soaking, heating and refluxing extraction secondary, merge extracted twice liquid, concentrated, then in every 100ml concentrated solution, add 0.5 ~ 2% chitosan solution of 15 ~ 30ml, after flocculation remove impurity, centrifugalize supernatant, concentrate and obtain Herba Taraxaci extract, every 1ml Herba Taraxaci extract is equivalent to crude drug 0.8 ~ 1.2g;
(2) get Herba Taraxaci extract 90 ~ 96ml that step (1) makes, add respectively 4.0 ~ 8.0g berberine hydrochloride, 0.03 ~ 0.05g atropine, stir, the pH value of adjusting solution is 5.0 ~ 7.0, then water is settled to 100ml, filtration, fill, sealing, sterilizing.
6. preparation method as claimed in claim 5, it is characterized in that: Herba Taraxaci extract obtains by the following method: get 100g Herba Taraxaci and soak after 1 ~ 2h, heating and refluxing extraction secondary, each extraction adds water 500 ~ 1000ml, 1 ~ 2h for the first time, 0.5 ~ 1.5h for the second time, merge extracted twice liquid, 60 ~ 70 ℃ are concentrated into 400 ~ 600ml, then in every 100ml concentrated solution, add 0.5 ~ 2% chitosan solution of 15 ~ 30ml, after flocculation remove impurity, centrifugalize supernatant, be concentrated into 100ml and obtain Herba Taraxaci extract, every 1ml Herba Taraxaci extract is equivalent to crude drug 1g.
7. the preparation method as described in claim 5 or 6, is characterized in that: in step (2), add and have adjuvant in Herba Taraxaci extract: 0.2 ~ 0.3g antiseptic, 0.05 ~ 0.2g stabilizing agent.
8. preparation method as claimed in claim 7, is characterized in that: described antiseptic is sodium benzoate, and described stabilizing agent is xanthan gum.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210426438.7A CN102973629B (en) | 2012-10-31 | 2012-10-31 | Oral liquid for preventing and treating intestinal diseases of livestock and poultry and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210426438.7A CN102973629B (en) | 2012-10-31 | 2012-10-31 | Oral liquid for preventing and treating intestinal diseases of livestock and poultry and preparation method thereof |
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| CN102973629B true CN102973629B (en) | 2014-10-22 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1184649A (en) * | 1996-12-13 | 1998-06-17 | 广东省翁源县青云山中药厂 | Traditional Chinese Medicine- |
| CN1857360A (en) * | 2006-03-16 | 2006-11-08 | 江西聚仁堂药业有限公司 | Capsule for treating enteritis and dysentery and its preparing process |
| CN101190203A (en) * | 2006-11-29 | 2008-06-04 | 天津市润拓生物技术有限公司 | Atropine sulfate chewable tablets for dog or cat |
-
2012
- 2012-10-31 CN CN201210426438.7A patent/CN102973629B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1184649A (en) * | 1996-12-13 | 1998-06-17 | 广东省翁源县青云山中药厂 | Traditional Chinese Medicine- |
| CN1857360A (en) * | 2006-03-16 | 2006-11-08 | 江西聚仁堂药业有限公司 | Capsule for treating enteritis and dysentery and its preparing process |
| CN101190203A (en) * | 2006-11-29 | 2008-06-04 | 天津市润拓生物技术有限公司 | Atropine sulfate chewable tablets for dog or cat |
Non-Patent Citations (2)
| Title |
|---|
| 辨证论治家禽泄泻症;马莉萍;《养殖技术顾问》;20091031(第10期);61 * |
| 马莉萍.辨证论治家禽泄泻症.《养殖技术顾问》.2009,(第10期), |
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Denomination of invention: The invention relates to an oral liquid for preventing and treating intestinal diseases of livestock and poultry and a preparation method thereof Effective date of registration: 20211224 Granted publication date: 20141022 Pledgee: China Construction Bank Corporation Zhengzhou Railway Sub Branch Pledgor: HENAN SOAR VETERINARY PHARMACEUTICAL Co.,Ltd. Registration number: Y2021980016170 |
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Denomination of invention: An oral liquid for preventing and treating intestinal diseases in livestock and poultry and its preparation method Granted publication date: 20141022 Pledgee: China Construction Bank Corporation Zhengzhou Railway Sub Branch Pledgor: HENAN SOAR VETERINARY PHARMACEUTICAL Co.,Ltd.|HENAN MUXIANG BIOTECHNOLOGY Co.,Ltd. Registration number: Y2024980004821 |
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