CN101879179A - Compound Ofloxacin solution and preparation method thereof - Google Patents
Compound Ofloxacin solution and preparation method thereof Download PDFInfo
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- CN101879179A CN101879179A CN2009100687450A CN200910068745A CN101879179A CN 101879179 A CN101879179 A CN 101879179A CN 2009100687450 A CN2009100687450 A CN 2009100687450A CN 200910068745 A CN200910068745 A CN 200910068745A CN 101879179 A CN101879179 A CN 101879179A
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Abstract
The invention discloses a compound Ofloxacin solution and a preparation method thereof, aiming at providing a solution with the advantages of treating digestive tract infections and respiratory tract infections of birds with rapid effect, treating both principal and secondary aspects of diseases and reducing drug-applied times and a preparation method thereof. The solution can be injected or orally taken and proper treating methods and administration approaches can be adopted according to disease states and the specific conditions of culturists. Every 100L of solutions comprises 1-10 kg of Ofloxacin, 3-15 kg of lincomycin hydrochloride, 0.05-0.5 kg of atropine sulfates, 0.2-2 kg of doxofylline, 0.01 kg of EDTA (Ethylene Diamine Tetraacetic Acid)-2Na, 10 kg of dimethylacetylamide and 0.5 L of hydrochloric acid. Because the Ofloxacin and the lincomycin hydrochloride are adopted as antibacterial components, the compound Ofloxacin solution can effectively solve the problems of bacterial drug resistance and takes effect on common bacteria causing the digestive tract infections and the respiratory tract infections; and meanwhile, the doxofylline can effectively relieve cough and asthma and inhibit respiratory symptoms, and the atropine sulfates have the rapid effects of inhibiting glandular secretion and reducing the liquid contents of digestive tracts and the respiratory tracts.
Description
Technical field
The present invention relates to a kind of compound Ofloxacin solution that is used for the treatment of fowl respiratory tract, digestive tract infection and preparation method thereof.
Background technology
Fowl respiratory tract, digestive tract infection are the diseases of the normal appearance of fowl in recent years, sick fowl shows as existing respiratory symptom, performance has situation such as diarrhoea dysentery etc. again, is mainly caused by mixed infections such as escherichia coli, Salmonella, mycoplasmas, and sick fowl undergrowth, morbidity are rapidly, mortality rate is very high.
At present, the trend of the oriented mixed type of disease, complicated development, add long-term breed, do not have the special aquaculture management of producing, simultaneously, the experience of culturist's medical diagnosis on disease aspect or the disease that grows with each passing hour, by common Therapeutic Method,, jumpbogroup is used inconvenient as single injection, and single oral administration does not reach the needs of quick treatment, the quick control state of an illness again.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, to provide a kind of and can treat fowl respiratory tract, digestive tract infection instant effect, and medication is flexible, and the fowl for the treatment of both the principal and secondary aspects of a disease is used compound Ofloxacin solution.
It is simple that another object of the present invention provides a kind of technology, and the above-mentioned fowl of realizing is easily used the preparation method of compound Ofloxacin solution.
The present invention is achieved through the following technical solutions:
A kind of compound Ofloxacin solution that is used for the treatment of fowl respiratory tract, digestive tract infection, it is characterized in that, consisting of of every 100L solution: ofloxacin 1～10kg, lincomycin hydrochloride 3～15kg, atropine sulfate 0.05～0.5kg, doxofylline 0.2～2kg, EDTA-2Na 0.01kg, dimethyl acetylamide 10kg, hydrochloric acid 0.5L, surplus is a water for injection.
A kind of above-mentioned preparation method that is used for the treatment of the compound Ofloxacin solution of fowl respiratory tract, digestive tract infection is characterized in that, comprises the steps:
(1) gets water for injection 50L, behind the dissolving EDTA-2Na 0.01kg, add hydrochloric acid 0.5L, after stirring, add ofloxacin 1～10kg, stirring and dissolving, after the dissolving, add lincomycin hydrochloride 3～15kg, atropine sulfate 0.05～0.5kg stirring and dissolving more successively.
(2) get dimethyl acetylamide 10kg, heating for dissolving doxofylline 0.2～2kg.
(3) combining step (1) and the prepared solution of step (2), after-teeming is penetrated water to 100L, is that 40% sodium hydroxide solution or mass percent concentration are that 10% hydrochloric acid solution is regulated pH value to 3.5～5.0 and promptly got fowl of the present invention and use compound Ofloxacin solution with mass percent concentration.Product after pH value meets the requirements with the fill of glass cillin bottle, adds butyl rubber plug, aluminium lid sealing, 100 ℃ of flowing steam sterilizations 30 minutes.
The preferable of wherein every 100L solution consists of: ofloxacin 2～6kg, lincomycin hydrochloride 5～10kg, atropine sulfate 0.1～0.3kg, doxofylline 0.5～1.5kg, EDTA-2Na 0.01kg, dimethyl acetylamide 10kg, hydrochloric acid 0.5L, surplus is a water for injection.
The best group of every 100L solution becomes: ofloxacin 4kg, and lincomycin hydrochloride 8kg, atropine sulfate 0.15kg, doxofylline 1kg, EDTA-2Na 0.01kg, dimethyl acetylamide 10kg, hydrochloric acid 0.5L, surplus is a water for injection.
Wherein, employed hydrochloric acid is commercially available analytical pure hydrochloric acid among the present invention.
The present invention has following technique effect:
The present invention is a compound preparation, adopts ofloxacin and lincomycin hydrochloride as antimicrobial component, has double effects, can effectively avoid the problem of bacterial drug resistance, and cause that to common the antibacterial of intestinal, respiratory tract infection is effective.Simultaneously, doxofylline effectively antitussive and antiasthmatic, suppress respiratory symptom, atropine sulfate suppresses glandular secretion, reduces digestive tract, respiratory tract fluid composition and play low-hanging fruit, treating both the principal and secondary aspects of a disease.
This product is for adopting a kind of solution of injection explained hereafter, not only can be by injection, but also can pass through the oral way administration, can be according to the situation rational use of drug of sick fowl morbidity, to rapid onset, the heavy employing injection of the state of an illness, treat that the state of an illness relaxes the back and adopts oral administration, the employing oral administration light slightly to the state of an illness, the force intensity that can lighten one's labor greatly like this, easy to use.This product broad-spectrum antiseptic is simultaneously avoided because of antibacterial produces drug resistance delay treatment opportunity to single antimicrobial component, and symptomatic treatment is accelerated disease recovery simultaneously, reduces economic loss.
Fowl of the present invention is simple with the preparation method technology of compound Ofloxacin solution, realizes easily.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
Embodiment 1
(1) get water for injection 50L, behind the dissolving EDTA-2Na 0.01kg, add hydrochloric acid 0.5L, after stirring, add ofloxacin 1kg, stirring and dissolving after the dissolving, adds lincomycin hydrochloride 15kg, atropine sulfate 0.5kg stirring and dissolving more successively.
(2) get dimethyl acetylamide 10kg, heating for dissolving doxofylline 0.2kg.
(3) the prepared solution of combining step 1 and step 2, after-teeming is penetrated water to 100L, is that 40% sodium hydroxide solution or mass percent concentration are that 10% hydrochloric acid solution is regulated pH value to 4.00 and promptly got fowl of the present invention and use compound Ofloxacin solution with mass percent concentration.After pH value meets the requirements,, add butyl rubber plug, aluminium lid sealing, 100 ℃ of flowing steam sterilizations 30 minutes with the fill of glass cillin bottle.
Embodiment 2
(1) get water for injection 50L, behind the dissolving EDTA-2Na 0.01kg, add hydrochloric acid 0.5L, after stirring, add ofloxacin 10kg, stirring and dissolving after the dissolving, adds lincomycin hydrochloride 3kg, atropine sulfate 0.05kg stirring and dissolving more successively.
(2) get dimethyl acetylamide 10kg, heating for dissolving doxofylline 2kg.
(3) the prepared solution of combining step 1 and step 2, after-teeming is penetrated water to 100L, is that 10% hydrochloric acid solution is regulated pH value to 4.20 and promptly got fowl of the present invention and use compound Ofloxacin solution with the sodium hydroxide solution of mass percent 40% or mass percent concentration.After pH value meets the requirements,, add butyl rubber plug, aluminium lid sealing, 100 ℃ of flowing steam sterilizations 30 minutes with the fill of glass cillin bottle.
Embodiment 3
(1) get water for injection 50L, behind the dissolving EDTA-2Na 0.01kg, add hydrochloric acid 0.5L, after stirring, add ofloxacin 2kg, stirring and dissolving after the dissolving, adds lincomycin hydrochloride 10kg, atropine sulfate 0.3kg stirring and dissolving more successively.
(2) get dimethyl acetylamide 10kg, heating for dissolving doxofylline 1.5kg.
(3) the prepared solution of combining step 1 and step 2, after-teeming is penetrated water to 100L, with the sodium hydroxide solution of mass percent 40% or mass percent concentration is that 10% hydrochloric acid solution is regulated pH value to 4.51 and promptly got fowl of the present invention and use compound Ofloxacin solution, after pH value meets the requirements, with the fill of glass cillin bottle, add the sealing of butyl rubber plug, aluminium lid, 100 ℃ of flowing steam sterilizations 30 minutes.
Embodiment 4
(1) get water for injection 50L, behind the dissolving EDTA-2Na 0.01kg, add hydrochloric acid 0.5L, after stirring, add ofloxacin 6kg, stirring and dissolving after the dissolving, adds lincomycin hydrochloride 5kg, atropine sulfate 0.1kg stirring and dissolving more successively.
(2) get dimethyl acetylamide 10kg, heating for dissolving doxofylline 0.5kg.
(3) the prepared solution of combining step 1 and step 2, after-teeming is penetrated water to 100L, with the sodium hydroxide solution of mass percent 40% or mass percent concentration is that 10% hydrochloric acid solution is regulated pH value to 3.82 and promptly got fowl of the present invention and use compound Ofloxacin solution, after pH value meets the requirements, with the fill of glass cillin bottle, add the sealing of butyl rubber plug, aluminium lid, 100 ℃ of flowing steam sterilizations 30 minutes.
Embodiment 5
(1) get water for injection 50L, behind the dissolving EDTA-2Na 0.01kg, add hydrochloric acid 0.5L, after stirring, add ofloxacin 5kg, stirring and dissolving after the dissolving, adds lincomycin hydrochloride 6kg, atropine sulfate 0.25kg stirring and dissolving more successively.
(2) get dimethyl acetylamide 10kg, heating for dissolving doxofylline 1.2kg.
(3) the prepared solution of combining step 1 and step 2, after-teeming is penetrated water to 100L, with the sodium hydroxide solution of mass percent 40% or mass percent concentration is that 10% hydrochloric acid solution is regulated pH value to 4.10 and promptly got fowl of the present invention and use compound Ofloxacin solution, after pH value meets the requirements, with the fill of glass cillin bottle, add the sealing of butyl rubber plug, aluminium lid, 100 ℃ of flowing steam sterilizations 30 minutes.
Embodiment 6
(1) get water for injection 50L, behind the dissolving EDTA-2Na 0.01kg, add hydrochloric acid 0.5L, after stirring, add ofloxacin 4kg, stirring and dissolving after the dissolving, adds lincomycin hydrochloride 8kg, atropine sulfate 0.15kg stirring and dissolving more successively.
(2) get dimethyl acetylamide 10kg, heating for dissolving doxofylline 1kg.
(3) the prepared solution of combining step 1 and step 2, after-teeming is penetrated water to 100L, with the sodium hydroxide solution of mass percent 40% or mass percent concentration is that 10% hydrochloric acid solution is regulated pH value to 4.22 and promptly got fowl of the present invention and use compound Ofloxacin solution, after pH value meets the requirements, with the fill of glass cillin bottle, add the sealing of butyl rubber plug, aluminium lid, 100 ℃ of flowing steam sterilizations 30 minutes.
Clinical trial:
Compound Ofloxacin solution of the present invention both can be used for the chicken class, also can be used for duck, goose etc.Be laboratory animal below with the chicken, the effect that is used for the treatment of the oral liquid of fowl respiratory tract, digestive tract infection of the present invention is experimentized.
1. laboratory animal:
1000 of the ill one-tenth of picked at random chickens, body weight is about 1kg.
2. experiment medicine
The compound Ofloxacin solution our unit development of the embodiment of the invention 6 preparations;
4% Ofloxacin solution our unit prepared in laboratory;
8% lincomycin hydrochloride injection our unit prepared in laboratory.
3. experimental technique:
Suffer from chicken with 1000 and be divided into four groups at random by body weight, 250 every group.
The A group does not give Drug therapy for the blank group.
The B group is treated usage with 4% Ofloxacin solution: drinking-water, every 1kg body weight 0.1ml, 2 times on the one, logotype 4 days.
The C group is treated usage with 8% lincomycin hydrochloride injection: intramuscular injection, every 1kg body weight 0.1ml, 2 times on the one, logotype 4 days.
The D group is treated usage with the compound ofloxacin injection of the embodiment of the invention 6 preparations: intramuscular injection in preceding 1 day, 2 times on the one, every 1kg body weight 0.1ml.2nd, 3 daily drinks, every 1kg body weight 0.1ml, 2 times on the one, logotype 2 days.
After the treatment beginning, every day, chicken health situation of change and dead animal distribution suffered from record, and treat and add up therapeutic effect after 5 days, wherein:
Invalid: as after referring to 5 days, to suffer from the chicken symptom and do not have obvious change, still keep the preceding symptom of treatment.
Effectively: after referring to 5 days, suffer from the chicken symptom and change, the effect before symptom is better than treating.
Cure: after referring to 5 days, transference cure is suffered from chicken and is got well.Its numeral is included in the significant digits.
Symptom is arranged during end: after referring to 5 days, suffer from chicken and still have certain symptom, its symptom performance is better than before the treatment or does not have change, suffers from chicken and does not cure.Its numeral has been included in the numeral of invalid number of elements and effective number of elements.
The relative weight gain rate: refer to use behind the medicine rate of body weight gain with respect to matched group.
Result of the test is as shown in table 1.
4. conclusion:
Analyze by statistics from the result of the test of table 1, the embodiment of the invention 6 is used for the treatment of compound Ofloxacin solution treatment group, 4% Ofloxacin solution treatment group and the 8% lincomycin hydrochloride injection group of digestive tract, respiratory tract and matched group difference extremely significantly (P＜0.01).Curative effect of the present invention is better than existing two kinds of medicines.
Table 1
Claims (6)
1. compound Ofloxacin solution that is used for the treatment of fowl respiratory tract, digestive tract infection, it is characterized in that, consisting of of every 100L solution: ofloxacin 1～10kg, lincomycin hydrochloride 3～15kg, atropine sulfate 0.05～0.5kg, doxofylline 0.2～2kg, EDTA-2Na 0.01kg, dimethyl acetylamide 10kg, hydrochloric acid 0.5L, surplus is a water for injection.
2. the compound Ofloxacin solution that is used for the treatment of fowl respiratory tract, digestive tract infection according to claim 1, it is characterized in that, consisting of of every 100L solution: ofloxacin 2～6kg, lincomycin hydrochloride 5～10kg, atropine sulfate 0.1～0.3kg, doxofylline 0.5～1.5kg, EDTA-2Na 0.01kg, dimethyl acetylamide 10kg, hydrochloric acid 0.5L, surplus is a water for injection.
3. the compound Ofloxacin solution that is used for the treatment of fowl respiratory tract, digestive tract infection according to claim 1, it is characterized in that, consisting of of every 100L solution: ofloxacin 4kg, lincomycin hydrochloride 8kg, atropine sulfate 0.15kg, doxofylline 1kg, EDTA-2Na 0.01kg, dimethyl acetylamide 10kg, hydrochloric acid 0.5L, surplus is a water for injection.
4. the described preparation method that is used for the treatment of the compound Ofloxacin solution of fowl respiratory tract, digestive tract infection of claim 1 is characterized in that, comprises the steps:
(1) gets water for injection 50L, behind the dissolving EDTA-2Na 0.01kg, add hydrochloric acid 0.5L, after stirring, add ofloxacin 1～10kg, stirring and dissolving, after the dissolving, add lincomycin hydrochloride 3～15kg, atropine sulfate 0.05～0.5kg stirring and dissolving more successively;
(2) get dimethyl acetylamide 10kg, heating for dissolving doxofylline 0.2～2kg;
(3) the prepared solution of combining step 1 and step 2, after-teeming is penetrated water to 100L, is that 40% sodium hydroxide solution or mass percent concentration are that 10% hydrochloric acid solution is regulated pH value to 3.5～5.0 and promptly got compound Ofloxacin solution of the present invention with mass percent concentration.
5. the preparation method that is used for the treatment of the compound Ofloxacin solution of fowl respiratory tract, digestive tract infection according to claim 4, it is characterized in that, consisting of of 100L solution: ofloxacin 2～6kg, lincomycin hydrochloride 5～10kg, atropine sulfate 0.1～0.3kg, doxofylline 0.5～1.5kg, EDTA-2Na 0.01kg, dimethyl acetylamide 10kg, hydrochloric acid 0.5L, surplus is a water for injection.
6. the preparation method that is used for the treatment of the compound Ofloxacin solution of fowl respiratory tract, digestive tract infection according to claim 4, it is characterized in that, consisting of of 100L solution: ofloxacin 4kg, lincomycin hydrochloride 8kg, atropine sulfate 0.15kg, doxofylline 1kg, EDTA-2Na 0.01kg, dimethyl acetylamide 10kg, hydrochloric acid 0.5L, surplus is a water for injection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100687450A CN101879179A (en) | 2009-05-05 | 2009-05-05 | Compound Ofloxacin solution and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100687450A CN101879179A (en) | 2009-05-05 | 2009-05-05 | Compound Ofloxacin solution and preparation method thereof |
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| CN101879179A true CN101879179A (en) | 2010-11-10 |
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| CN2009100687450A Pending CN101879179A (en) | 2009-05-05 | 2009-05-05 | Compound Ofloxacin solution and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102784108A (en) * | 2011-05-18 | 2012-11-21 | 兆科药业（合肥）有限公司 | Ulifloxacin water-soluble salt injection |
| CN103340878A (en) * | 2013-07-05 | 2013-10-09 | 成都乾坤动物药业有限公司 | Compound ofloxacin solution for veterinary use and preparation process of compound ofloxacin solution |
-
2009
- 2009-05-05 CN CN2009100687450A patent/CN101879179A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102784108A (en) * | 2011-05-18 | 2012-11-21 | 兆科药业（合肥）有限公司 | Ulifloxacin water-soluble salt injection |
| CN103340878A (en) * | 2013-07-05 | 2013-10-09 | 成都乾坤动物药业有限公司 | Compound ofloxacin solution for veterinary use and preparation process of compound ofloxacin solution |
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Application publication date: 20101110 |