CN101297808B - Compound ofloxacin injection for fowl and preparation method thereof - Google Patents
Compound ofloxacin injection for fowl and preparation method thereof Download PDFInfo
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- CN101297808B CN101297808B CN2008100526435A CN200810052643A CN101297808B CN 101297808 B CN101297808 B CN 101297808B CN 2008100526435 A CN2008100526435 A CN 2008100526435A CN 200810052643 A CN200810052643 A CN 200810052643A CN 101297808 B CN101297808 B CN 101297808B
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Abstract
The invention discloses an avian compound ofloxacin injection and a preparation method thereof, which aims at providing the avian compound ofloxacin injection that has rapid onset of action for the treatment for avian colibacillosis, effectivity, high efficiency and can ease the diseased avian stress reactions, treat both manifestation and root cause of disease, reduce the times and dosage of drugfor being taken and reduce occurrence of the residual drugs exceeding the standards, and the preparation method that has simple technology and easy realization. Each 100l injection contains: 0.5 to 5kg of the ofloxacin, 3 to 15kg of neomycin sulfate, 0.2kg of sodium bisulfite, 500 to 2000ml of hydrochloric acid, 0.01kg of EDTA-2Na and 0.06kg of dexamethasone sodium phosphate. By adopting a compound preparation which combines anti-bacterial drugs and antibiotics for usage, and the combining usage of the ofloxacin, the neomycin sulfate and the dexamethasone sodium phosphate, the injection of the invention has rapid onset of action for avian colibacillosis, effectivity and high efficiency and can significantly ease the clinical symptoms caused by avian colibacillosis, treat both manifestation and root cause of disease, prevent the secondary infection and increase the weight of birds.
Description
Technical field
The present invention relates to a kind of compound ofloxacin injection for fowl and preparation method thereof.
Background technology
Chicken colibacillosis is the class commonly encountered diseases of chicken, comprises types such as escherichia coli airsacculitis, septicemia, salpingitis, peritonitis, brings very big loss to poultry husbandry.Escherichia coli are one of resident bacterium in Intestinum Gallus domesticus road, function with certain assist digestion, pathogenic 10～15% of the total bacteria count that accounts for is arranged, and do not have an attack of one's old illness usually, after environment changes, can cause morbidity, and have infectiousness, mainly pollute surrounding, utensil propagation, cause that chicken infects by defecate, but and other infection of secondary, mortality rate is higher.
The medicine of treatment chicken colibacillosis employing as ofloxacin, polygynax etc., mainly by oral medication, and uses separately at present.Owing to the absorption problem and because antibacterial produces drug resistance and sensitivity reduces, make therapeutic effect decline separately, have even readily good therapeutic effect, the meeting that has is because secondary infection causes the generation of other diseases.And the raiser is in order to treat disease, increases dosage or extends working time, and exceeds standard and drug residue occurs.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, to provide a kind of and can treat various birds colibacillosis, and instant effect can prevent to infect and secondary infection the compound ofloxacin injection for fowl for the treatment of both the principal and secondary aspects of a disease.
It is simple that another object of the present invention provides a kind of technology, easily the preparation method of the above-mentioned compound ofloxacin injection for fowl of realizing.
The present invention is achieved through the following technical solutions:
A kind of compound ofloxacin injection for fowl, it is characterized in that, every 100L injection is made by following component: ofloxacin 0.5～5kg, polygynax 3～15kg, sodium sulfite 0.2kg, hydrochloric acid 500～2000ml, EDTA-2Na 0.01kg, dexamethasone sodium phosphate 0.06kg, surplus is a water for injection.
The preferable content of each component is in wherein every 100L injection: ofloxacin 0.7～4kg, and polygynax 5～12kg, hydrochloric acid 700～1500ml, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, dexamethasone sodium phosphate 0.06kg, surplus is a water for injection.
The optimum content of each component is in every 100L injection: ofloxacin 0.7～4kg, and polygynax 5～12kg, hydrochloric acid 700～1500ml, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, dexamethasone sodium phosphate 0.06kg, surplus is a water for injection.
A kind of preparation method of compound ofloxacin injection for fowl is characterized in that, comprises the steps
(1) takes by weighing ofloxacin 0.5～5kg and put into water for injection 10-30L, add hydrochloric acid 500～2000ml again, be stirred to whole dissolvings;
(2) polygynax 3～15kg is put into water for injection 10-30L, be stirred to whole dissolvings after, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg, dexamethasone sodium phosphate 0.06kg more successively, be stirred to whole dissolvings;
(3) the prepared solution of combining step 1 and step 2 adds water for injection again to 100L, stirs, and keeps 15-20min, treats that medicinal liquid promptly makes compound ofloxacin injection for fowl of the present invention after clear and bright.
The preferable of wherein every 100L injection consists of: ofloxacin 0.7～4kg, and polygynax 5～12kg, hydrochloric acid 700～1500ml, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, dexamethasone sodium phosphate 0.06kg, surplus is a water for injection.
The best group of every 100L injection becomes: ofloxacin 2kg, and polygynax 10kg, hydrochloric acid 1000ml, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, dexamethasone sodium phosphate 0.06kg, surplus is a water for injection.
The present invention has following technique effect:
The compound preparation of the present invention for adopting antimicrobial drug and antibiotic to share, ofloxacin and polygynax are united use, adopt double effects, dual bacteriostasis and sterilization, reduce antibacterial and produce chemical sproof probability, and the sensitivity of increase antibacterial, add antiinflammatory, detoxifcation, the anti-allergic effects of dexamethasone sodium phosphate, and by to the rational proportion of each amounts of components, fast to responding well to treatment of the colibacillosis of birds, effectively and efficient, can alleviate and suffer from birds health stress, treating both the principal and secondary aspects of a disease can prevent secondary infection, increases the body weight of birds.Simultaneously, compound preparation of the present invention is an injection, helps absorbing.Because therapeutic process is accelerated, and has reduced medication number of times and dosage, can reduce and drug residue occurs and exceed standard.
The preparation method technology of compound ofloxacin injection for fowl of the present invention is simple, realizes easily.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
Embodiment 1
(1) takes by weighing ofloxacin 0.5kg and put into water for injection 10L, add hydrochloric acid 500ml again, be stirred to whole dissolvings;
(2) polygynax 15kg is put into water for injection 30L, be stirred to whole dissolvings after, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg, dexamethasone sodium phosphate 0.06kg more successively, be stirred to whole dissolvings;
(3) the prepared solution of combining step 1 and step 2 adds water for injection again to 100L, stirs, and keeps 15-20min, treats that medicinal liquid promptly makes compound ofloxacin injection for fowl of the present invention after clear and bright.
Embodiment 2
(1) takes by weighing ofloxacin 5kg and put into water for injection 30L, add hydrochloric acid 2000ml again, be stirred to whole dissolvings;
(2) polygynax 3kg is put into water for injection 10L, be stirred to whole dissolvings after, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg, dexamethasone sodium phosphate 0.06kg more successively, be stirred to whole dissolvings;
(3) the prepared solution of combining step 1 and step 2 adds water for injection again to 100L, stirs, and keeps 15-20min, treats that medicinal liquid promptly makes compound ofloxacin injection for fowl of the present invention after clear and bright.
Embodiment 3
(1) takes by weighing ofloxacin 0.7kg and put into water for injection 10L, add hydrochloric acid 700ml again, be stirred to whole dissolvings;
(2) polygynax 12kg is put into water for injection 30L, be stirred to whole dissolvings after, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg, dexamethasone sodium phosphate 0.06kg more successively, be stirred to whole dissolvings;
(3) the prepared solution of combining step 1 and step 2 adds water for injection again to 100L, stirs, and keeps 15-20min, treats that medicinal liquid promptly makes compound ofloxacin injection for fowl of the present invention after clear and bright.
Embodiment 4
(1) takes by weighing ofloxacin 4kg and put into water for injection 30L, add hydrochloric acid 1500ml again, be stirred to whole dissolvings;
(2) polygynax 5kg is put into water for injection 10L, be stirred to whole dissolvings after, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg, dexamethasone sodium phosphate 0.06kg more successively, be stirred to whole dissolvings;
(3) the prepared solution of combining step 1 and step 2 adds water for injection again to 100L, stirs, and keeps 15-20min, treats that medicinal liquid promptly makes compound ofloxacin injection for fowl of the present invention after clear and bright.
Embodiment 5
(1) takes by weighing ofloxacin 3kg and put into water for injection 20L, add hydrochloric acid 1200ml again, be stirred to whole dissolvings;
(2) polygynax 9kg is put into water for injection 20L, be stirred to whole dissolvings after, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg, dexamethasone sodium phosphate 0.06kg more successively, be stirred to whole dissolvings;
(3) the prepared solution of combining step 1 and step 2 adds water for injection again to 100L, stirs, and keeps 15-20min, treats that medicinal liquid promptly makes compound ofloxacin injection for fowl of the present invention after clear and bright.
Embodiment 6
(1) takes by weighing ofloxacin 2kg and put into water for injection 20L, add hydrochloric acid 1000ml again, be stirred to whole dissolvings;
(2) polygynax 10kg is put into water for injection 30L, be stirred to whole dissolvings after, add sodium sulfite 0.2kg, EDTA-2Na 0.01k g, dexamethasone sodium phosphate 0.06kg more successively, be stirred to whole dissolvings;
(3) the prepared solution of combining step 1 and step 2 adds water for injection again to 100L, stirs, and keeps 15-20min, treats that medicinal liquid promptly makes compound ofloxacin injection for fowl of the present invention after clear and bright.
Clinical trial:
1. laboratory animal:
1000 of the ill one-tenth of picked at random chickens, body weight is at 1～2kg.
2. experiment medicine
The compound ofloxacin injection our unit development of the embodiment of the invention 6 preparations;
Ofloxacin solution our unit prepared in laboratory;
Neomycin sulphate solution our unit prepared in laboratory.
3. experimental technique:
Suffer from chicken with 1000 and be divided into four groups at random by body weight, 250 every group.
The A group does not give Drug therapy for the blank group.
The B group is treated usage with the ofloxacin oral liquid: drinking-water, every 1kg body weight 10mg, 2 times on the one, logotype 4 days.
The C group is treated usage with neomycin sulfate oral solution: drinking-water, every 1kg body weight 20mg, 2 times on the one, logotype 4 days.
The D group is treated usage with the compound ofloxacin injection of the embodiment of the invention 6 preparations: intramuscular injection, every 1kg body weight 0.2ml, 1 time on the one, logotype 2 times.
After the treatment beginning, every day, fowl health situation of change and dead animal distribution suffered from record, and treat and add up therapeutic effect after 5 days, wherein:
Invalid: as after referring to 5 days, to suffer from the fowl symptom and do not have obvious change, still keep the preceding symptom of treatment.
Effectively: after referring to 5 days, suffer from the fowl symptom and change, the effect before symptom is better than treating.
Cure: after referring to 5 days, transference cure is suffered from fowl and is got well.Its numeral is included in the significant digits.
Symptom is arranged during end: after referring to 5 days, suffer from fowl and still have certain symptom, its symptom performance is better than before the treatment or does not have change, suffers from fowl and does not cure.Its numeral has been included in the numeral of invalid number of elements and effective number of elements.
The relative weight gain rate: refer to use behind the medicine rate of body weight gain with respect to matched group.
Result of the test is as shown in table 1.
4. conclusion:
Analyze by statistics from the result of the test of table 1, compound ofloxacin injection treatment group, ofloxacin oral liquid treatment group and neomycin sulfate oral solution group and matched group difference is (P＜0.01=extremely significantly.Curative effect of the present invention is better than existing two kinds of medicines.
Table 1
| Numbering | Group | Invalid number of elements | Effective number of elements | Cure number of elements | Symptom chicken number is arranged during end | Dead number of elements | The relative weight gain rate % |
| A | Matched group | 250 | 0 | 0 | 132 | 118 | 0 |
| B | The ofloxacin oral liquid treatment | 65 | 185 | 130 | 80 | 40 | 65.2 |
| C | The neomycin sulfate oral solution treatment | 73 | 177 | 122 | 74 | 54 | 20.5 |
| D | The compound ofloxacin injection treatment | 27 | 223 | 204 | 27 | 19 | 80.0 |
Claims (5)
1. compound ofloxacin injection for fowl, it is characterized in that, every 100L injection is made by following component: ofloxacin 0.5～5kg, polygynax 3～15kg, sodium sulfite 0.2kg, hydrochloric acid 500～2000ml, EDTA-2Na0.01kg, dexamethasone sodium phosphate 0.06kg, surplus is a water for injection.
2. compound ofloxacin injection for fowl according to claim 1, it is characterized in that, every 100L injection is made by following component: ofloxacin 0.7～4kg, polygynax 5～12kg, hydrochloric acid 700～1500ml, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, dexamethasone sodium phosphate 0.06kg, surplus is a water for injection.
3. the preparation method of a compound ofloxacin injection for fowl is characterized in that, comprises the steps:
(1) takes by weighing ofloxacin 0.5～5kg and put into water for injection 10-30L, add hydrochloric acid 500～2000ml again, be stirred to whole dissolvings;
(2) take by weighing polygynax 3～15kg and put into water for injection 10-30L, be stirred to whole dissolvings after, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg, dexamethasone sodium phosphate 0.06kg more successively, be stirred to whole dissolvings;
(3) the prepared solution of combining step 1 and step 2 adds water for injection again to 100L, stirs, and keeps 15-20min, treats that medicinal liquid promptly makes compound ofloxacin injection for fowl after clear and bright.
4. the preparation method of compound ofloxacin injection for fowl according to claim 3, it is characterized in that, ofloxacin 0.7～4kg in every 100L injection, polygynax 5～12kg, hydrochloric acid 700～1500ml, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, dexamethasone sodium phosphate 0.06kg, surplus is a water for injection.
5. the preparation method of compound ofloxacin injection for fowl according to claim 3, it is characterized in that, ofloxacin 2kg in every 100L injection, polygynax 10kg, hydrochloric acid 1000ml, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, dexamethasone sodium phosphate 0.06kg, surplus is a water for injection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100526435A CN101297808B (en) | 2008-04-08 | 2008-04-08 | Compound ofloxacin injection for fowl and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008100526435A CN101297808B (en) | 2008-04-08 | 2008-04-08 | Compound ofloxacin injection for fowl and preparation method thereof |
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| CN101297808A CN101297808A (en) | 2008-11-05 |
| CN101297808B true CN101297808B (en) | 2010-06-09 |
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| CN2008100526435A Expired - Fee Related CN101297808B (en) | 2008-04-08 | 2008-04-08 | Compound ofloxacin injection for fowl and preparation method thereof |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101843625B (en) * | 2010-03-30 | 2012-02-08 | 重庆巴仕迪动物药业有限公司 | Compound ofloxacin injection for livestock and preparation method thereof |
| CN102847160B (en) * | 2012-09-07 | 2014-05-21 | 广东大华农动物保健品股份有限公司 | Compound quinolone injection for livestock, and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1326735A (en) * | 2000-06-05 | 2001-12-19 | 诸城市信得药业有限责任公司 | Yangru ofloxacin and its production process |
| EP1262185A1 (en) * | 2001-05-30 | 2002-12-04 | New Pharma Research Sweden AB | Synergistic antibiotic compositions |
| CN101007164A (en) * | 2007-01-23 | 2007-08-01 | 天津生机集团有限公司 | Compound ofloxacin injection and its preparation method |
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2008
- 2008-04-08 CN CN2008100526435A patent/CN101297808B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1326735A (en) * | 2000-06-05 | 2001-12-19 | 诸城市信得药业有限责任公司 | Yangru ofloxacin and its production process |
| EP1262185A1 (en) * | 2001-05-30 | 2002-12-04 | New Pharma Research Sweden AB | Synergistic antibiotic compositions |
| CN101007164A (en) * | 2007-01-23 | 2007-08-01 | 天津生机集团有限公司 | Compound ofloxacin injection and its preparation method |
Non-Patent Citations (4)
| Title |
|---|
| 刘聚祥.我国部分地区鸡致病性大肠杆菌的耐药性检测与分析.河北农业大学学报30 5.2007,30(5),94-95. |
| 刘聚祥.我国部分地区鸡致病性大肠杆菌的耐药性检测与分析.河北农业大学学报30 5.2007,30(5),94-95. * |
| 杨建平等.猪病原性大肠杆菌对15种抗菌药物的药敏试验.河南农业科学 9.2002,(9),40-41. |
| 杨建平等.猪病原性大肠杆菌对15种抗菌药物的药敏试验.河南农业科学 9.2002,(9),40-41. * |
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