CN101601676A - Compound hydrochloric acid oxytetracycline soluble powder and preparation method that the treatment spirochaeta gallinarum infects - Google Patents
Compound hydrochloric acid oxytetracycline soluble powder and preparation method that the treatment spirochaeta gallinarum infects Download PDFInfo
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- CN101601676A CN101601676A CNA2009103047333A CN200910304733A CN101601676A CN 101601676 A CN101601676 A CN 101601676A CN A2009103047333 A CNA2009103047333 A CN A2009103047333A CN 200910304733 A CN200910304733 A CN 200910304733A CN 101601676 A CN101601676 A CN 101601676A
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- spirochaeta
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- soluble powder
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Abstract
The invention discloses a kind of compound hydrochloric acid oxytetracycline soluble powder and preparation method that spirochaeta gallinarum infects for the treatment of, aim to provide a kind of treatment spirochaeta gallinarum and infect instant effect, safe in utilization, effectively and efficiently compound hydrochloric acid oxytetracycline soluble powder and preparation method.Consisting of by weight percentage: tetramycin hydrochloride 5～15%, Mequindox 5～15%, acetaminophen 5～20%, vitamin K
32%, surplus is an anhydrous glucose.The present invention adopts tetramycin hydrochloride and Mequindox to reduce the drug resistance of pathogen, improves therapeutic effect, simultaneously in conjunction with antipyretic acetaminophen and the vitamin K that hemostatic function is arranged
3, the treatment spirochaeta gallinarum infects instant effect, and curative effect is outstanding, and can effectively prevent other bacterial infections.
Description
Technical field
The present invention relates to a kind of compound hydrochloric acid oxytetracycline soluble powder that spirochaeta gallinarum infects that is used for the treatment of.
Background technology
It is the infectious disease that is caused by spirochaeta gallinarum that spirochaeta gallinarum infects, and clinical principal character is depressed for heating, spirit, loss of appetite or do not eat, and happiness drinking-water continues row's light green color loose stool etc.
Now because antibiotic medicine widely makes cause of disease produce stronger drug resistance, add being characterized as of the primary disease pathological characters such as declines, happiness drinking-water, hemorrhage, heating of searching for food, treat for numerous raisers and bring very big inconvenience, cause very big loss.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, to provide a kind of spirochaeta gallinarum of can treating to infect instant effect, the compound hydrochloric acid oxytetracycline soluble powder for the treatment of both the principal and secondary aspects of a disease.
The present invention is achieved through the following technical solutions:
A kind of compound hydrochloric acid oxytetracycline soluble powder that is used for the treatment of the spirochaeta gallinarum infection is characterized in that, is made up of following raw material by weight percentage: tetramycin hydrochloride 5～15%, Mequindox 5～15%, acetaminophen 5～20%, vitamin K
32%, surplus is an anhydrous glucose.
A kind of above-mentioned preparation method that is used for the treatment of the compound oxytetracycline soluble powder of spirochaeta gallinarum infection is characterized in that, comprises the steps: tetramycin hydrochloride, Mequindox, acetaminophen, vitamin K
3, after the anhydrous glucose pulverize separately sieves, get tetramycin hydrochloride 5～15% by weight percentage, Mequindox 5～15%, acetaminophen 5～20%, vitamin K
32%, the anhydrous glucose of surplus fully mixed 1 hour, behind the mixing, promptly got the compound hydrochloric acid oxytetracycline soluble powder that spirochaeta gallinarum infects that is used for the treatment of of the present invention.
Wherein preferable consisting of: tetramycin hydrochloride 8～12% by weight percentage, Mequindox 7～13%, acetaminophen 8～12%, vitamin K
32%, surplus is an anhydrous glucose.
Best group becomes: tetramycin hydrochloride 10% by weight percentage, Mequindox 10%, acetaminophen 10%, vitamin K
32%, surplus is an anhydrous glucose.
The present invention has following technique effect:
Compound hydrochloric acid oxytetracycline soluble powder of the present invention adopts two kinds of disease-resistant ultimate constituents: tetramycin hydrochloride and Mequindox, both share, can reduce the drug resistance of spirochaeta gallinarum greatly, improve disease-resistant former ability, and other antibacterials are also had stronger inhibition and killing action, can prevent the generation of other bacterial infections of secondary, simultaneously, in conjunction with the analgesic function of acetaminophen, vitamin K
3Hemostasis, suppress hemorrhage function, by the rational combination collocation of several drugs, the treatment spirochaeta gallinarum infects instant effect, prevents secondary infection, the cure rate height.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
With tetramycin hydrochloride, Mequindox, acetaminophen, vitamin K
3, to cross No. 5 sieves behind the anhydrous glucose pulverize separately standby.
Embodiment 1
Take by weighing tetramycin hydrochloride 5kg, Mequindox 15kg, acetaminophen 20kg, vitamin K after sieving
32kg, anhydrous glucose 58kg fully mixed 1 hour, promptly got the compound hydrochloric acid oxytetracycline soluble powder that treatment spirochaeta gallinarum of the present invention infects.
Embodiment 2
Take by weighing tetramycin hydrochloride 15kg, Mequindox 5kg, acetaminophen 5kg, vitamin K after sieving
32kg, anhydrous glucose 73kg fully mixed 1 hour, promptly got the compound hydrochloric acid oxytetracycline soluble powder that treatment spirochaeta gallinarum of the present invention infects.
Embodiment 3
Take by weighing tetramycin hydrochloride 8kg, Mequindox 13kg, acetaminophen 8kg, vitamin K after sieving
32kg, anhydrous glucose 69kg fully mixed 1 hour, promptly got the compound hydrochloric acid oxytetracycline soluble powder that treatment spirochaeta gallinarum of the present invention infects.
Embodiment 4
Take by weighing tetramycin hydrochloride 12kg, Mequindox 7kg, acetaminophen 12kg, vitamin K after sieving
32kg, anhydrous glucose 67kg fully mixed 1 hour, promptly got the compound hydrochloric acid oxytetracycline soluble powder that treatment spirochaeta gallinarum of the present invention infects.
Embodiment 5
Take by weighing tetramycin hydrochloride 11kg, Mequindox 9kg, acetaminophen 11kg, vitamin K after sieving
32kg, anhydrous glucose 67kg fully mixed 1 hour, promptly got the compound hydrochloric acid oxytetracycline soluble powder that treatment spirochaeta gallinarum of the present invention infects.
Embodiment 6
Take by weighing tetramycin hydrochloride 10kg, Mequindox 10kg, acetaminophen 10kg, vitamin K after sieving
32kg, anhydrous glucose 68kg fully mixed 1 hour, promptly got the compound hydrochloric acid oxytetracycline soluble powder that treatment spirochaeta gallinarum of the present invention infects.
Clinical trial:
1. laboratory animal:
1000 of the ill one-tenth of picked at random chickens, body weight is about about 1kg.
2. experiment medicine
The compound hydrochloric acid oxytetracycline soluble powder our unit development of the embodiment of the invention 6 preparations;
10% Mequindox powder our unit prepared in laboratory;
10% oxycycline soluble powder our unit prepared in laboratory.
3. experimental technique:
Suffer from chicken with 1000 and be divided into four groups at random by body weight, 250 every group.
The A group does not give Drug therapy for the blank group.
The B group is treated usage with 10% Mequindox powder: drinking-water, every 1L water 1g, 2 times on the one, logotype 4 days.
The C group is treated usage with 10% oxycycline soluble powder: drinking-water, every 1L water 1g, 2 times on the one, logotype 4 days.
The D group is treated usage with the compound hydrochloric acid oxytetracycline soluble powder of the embodiment of the invention 6 preparations: drinking-water, every 1L water 1g, 2 times on the one, logotype 3 days.
After the treatment beginning, every day, chicken health situation of change and dead animal distribution suffered from record, and treat and add up therapeutic effect after 7 days, wherein:
Invalid: as after referring to 7 days, to suffer from the chicken symptom and do not have obvious change, still keep the preceding symptom of treatment.
Effectively: after referring to 7 days, suffer from the chicken symptom and change, the effect before symptom is better than treating.
Cure: after referring to 7 days, transference cure is suffered from chicken and is got well.Its numeral is included in the significant digits.
Symptom is arranged during end: after referring to 7 days, suffer from chicken and still have certain symptom, its symptom performance is better than before the treatment or does not have change, suffers from chicken and does not cure.Its numeral has been included in the numeral of invalid number of elements and effective number of elements.
The relative weight gain rate: refer to use behind the medicine rate of body weight gain with respect to matched group.
Result of the test is as shown in table 1.
4. conclusion:
Analyze by statistics from the result of the test of table 1, the embodiment of the invention 6 is used for the treatment of compound hydrochloric acid oxytetracycline soluble powder treatment group, 10% Mequindox treated powder group and 10% oxycycline soluble powder group that spirochaeta gallinarum infects and matched group difference extremely remarkable (P＜0.01).Curative effect of the present invention is better than existing two kinds of medicines.
Table 1
| Numbering | Group | Invalid number of elements | Effective number of elements | Cure number of elements | Symptom chicken number is arranged during end | Dead number of elements | The relative weight gain rate % |
| ??A | Matched group | ??250 | ??0 | ??0 | ??132 | ??118 | ??0 |
| ??B | 10% Mequindox treated powder | ??185 | ??65 | ??50 | ??140 | ??60 | ??20.5 |
| ??C | The treatment of 10% oxycycline soluble powder | ??73 | ??177 | ??122 | ??74 | ??54 | ??62.3 |
| ??D | The compound hydrochloric acid oxytetracycline soluble powder of the embodiment of the invention 6 | ??26 | ??224 | ??205 | ??25 | ??20 | ??80.0 |
Claims (4)
1. one kind is used for the treatment of the compound hydrochloric acid oxytetracycline soluble powder that spirochaeta gallinarum infects, and it is characterized in that, is made up of following raw material by weight percentage: tetramycin hydrochloride 5～15%, Mequindox 5～15%, acetaminophen 5～20%, vitamin K3 2%, surplus is an anhydrous glucose.
2. the compound hydrochloric acid oxytetracycline soluble powder that is used for the treatment of the spirochaeta gallinarum infection according to claim 1, it is characterized in that, form by following raw material by weight percentage: tetramycin hydrochloride 8～12%, Mequindox 7～13%, acetaminophen 8～12%, vitamin K3 2%, surplus are anhydrous glucose.
3. the compound hydrochloric acid oxytetracycline soluble powder that is used for the treatment of the spirochaeta gallinarum infection according to claim 1, it is characterized in that, form by following raw material by weight percentage: tetramycin hydrochloride 10%, Mequindox 10%, acetaminophen 10%, vitamin K3 2%, surplus are anhydrous glucose.
4. the described preparation method that is used for the treatment of the compound hydrochloric acid oxytetracycline soluble powder that spirochaeta gallinarum infects of a claim 1, it is characterized in that, comprise the steps: tetramycin hydrochloride, Mequindox, acetaminophen, vitamin K3, after the anhydrous glucose pulverize separately sieves, get tetramycin hydrochloride 5～15% by weight percentage, Mequindox 5～15%, acetaminophen 5～20%, vitamin K3 2%, the anhydrous glucose of surplus fully mixed 1 hour, behind the mixing, promptly get the compound hydrochloric acid oxytetracycline soluble powder that spirochaeta gallinarum infects that is used for the treatment of of the present invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009103047333A CN101601676A (en) | 2009-07-23 | 2009-07-23 | Compound hydrochloric acid oxytetracycline soluble powder and preparation method that the treatment spirochaeta gallinarum infects |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009103047333A CN101601676A (en) | 2009-07-23 | 2009-07-23 | Compound hydrochloric acid oxytetracycline soluble powder and preparation method that the treatment spirochaeta gallinarum infects |
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| CN101601676A true CN101601676A (en) | 2009-12-16 |
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| CNA2009103047333A Pending CN101601676A (en) | 2009-07-23 | 2009-07-23 | Compound hydrochloric acid oxytetracycline soluble powder and preparation method that the treatment spirochaeta gallinarum infects |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102133206A (en) * | 2011-03-21 | 2011-07-27 | 郑州百瑞动物药业有限公司 | Oxytetracycline hydrochloride effervescent tablet for dairy cattle and preparation method thereof |
-
2009
- 2009-07-23 CN CNA2009103047333A patent/CN101601676A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102133206A (en) * | 2011-03-21 | 2011-07-27 | 郑州百瑞动物药业有限公司 | Oxytetracycline hydrochloride effervescent tablet for dairy cattle and preparation method thereof |
| CN102133206B (en) * | 2011-03-21 | 2012-05-30 | 郑州百瑞动物药业有限公司 | Oxytetracycline hydrochloride effervescent tablet for dairy cattle and preparation method thereof |
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Application publication date: 20091216 |