CN101606945A - Compound sodium sulfadimidine injection liquid for pig and preparation method thereof - Google Patents
Compound sodium sulfadimidine injection liquid for pig and preparation method thereof Download PDFInfo
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- CN101606945A CN101606945A CNA2009103047386A CN200910304738A CN101606945A CN 101606945 A CN101606945 A CN 101606945A CN A2009103047386 A CNA2009103047386 A CN A2009103047386A CN 200910304738 A CN200910304738 A CN 200910304738A CN 101606945 A CN101606945 A CN 101606945A
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Abstract
The invention discloses a kind of compound sodium sulfadimidine injection liquid for pig and preparation method thereof, aim to provide a kind of treatment swine toxoplasmosis instant effect, treating both the principal and secondary aspects of a disease, reduce medication number of times and dosage, medication compound sodium sulfadimidine injection liquid and technology thereof easily is simple, easily the preparation method that realizes.Every 100L injection comprises: sulfadimidine sodium 5～20kg, lincomycin hydrochloride 1～10kg, aminophenazone 5～20kg, trimethoprim 1～4kg, sodium sulfite 0.2kg, EDTA-2Na0.01kg, propylene glycol 40kg, 95% ethanol 10kg, surplus is a water for injection.Injection of the present invention is by the several drugs rational proportion, and is fast to responding well to treatment of the toxoplasmosis of pig, treating both the principal and secondary aspects of a disease, and can effectively treat and pre-bacteriological protection secondary infection, reduce the pathogenic microorganism drug resistance, make pig recover to accelerate.Simultaneously, compound preparation of the present invention is injection, and is easy to use.
Description
Technical field
The present invention relates to a kind of compound sodium sulfadimidine injection liquid for pig and preparation method thereof.
Background technology
It is the common a kind of disease of pig that the pig toxoplasma infects, main clinical manifestation has hyperpyrexia, spirit is depressed, dyspnea, the obvious enlargement of lymph node, lower body part, have sharp ears have congestion speckle or large tracts of land cyanosis, prolongation along with the state of an illness, be easy to other bacterial infections of secondary, primary disease has very strong infectiousness, and mortality rate is very high.
Because primary disease is generally fallen ill in recent years, medication is spread unchecked, pathogen produces stronger drug resistance and causes common single drug therapeutic effect not good, and owing to there is not symptomatic treatment, or symptomatic treatment only, and can not treat disease fast and effectively, and cause pig death, bring very big loss for numerous culturists.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, providing a kind of can reduce the pathogenic microorganism drug resistance to sick, symptomatic treatment swine toxoplasmosis, and it is fast to respond well to treatment, clinical symptoms when energy alleviation trouble pig is ill, compound sodium sulfadimidine injection liquid for pig easy to use.
It is simple that another object of the present invention provides a kind of technology, easily the preparation method of the above-mentioned compound sodium sulfadimidine injection liquid for pig of realizing.
The present invention is achieved through the following technical solutions:
A kind of compound sodium sulfadimidine injection liquid for pig, it is characterized in that, consisting of of every 100L injection: sulfadimidine sodium 5～20kg, lincomycin hydrochloride 1～10kg, aminophenazone 5～20kg, trimethoprim 1～4kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, propylene glycol 40kg, 95% ethanol 10kg, surplus is a water for injection.
A kind of preparation method of compound sodium sulfadimidine injection liquid for pig is characterized in that, comprises the steps:
(1) gets water for injection 30L, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg, after the stirring and dissolving, add sulfadimidine sodium 5～20kg again, be stirred to whole dissolvings.
(2) get propylene glycol 40kg, be heated to about 80 ℃ dissolving trimethoprim 1～4kg, lincomycin hydrochloride 1～10kg, aminophenazone 5～20kg, all dissolve about postcooling to 50 ℃.
(3) combining step (1) and the prepared solution of step (2), add 95% ethanol 10kg, add water for injection again to 100L, stir, keep 15-20min, with mass percent concentration is that 40% sodium hydroxide solution or concentration of volume percent are that 10% hydrochloric acid solution is regulated pH value to 10.00～11.00, treats that medicinal liquid promptly makes compound sodium sulfadimidine injection liquid for pig of the present invention after clear and bright.
The preferable of wherein every 100L injection consists of: sulfadimidine sodium 8～15kg, lincomycin hydrochloride 3～7kg, aminophenazone 8～15kg, trimethoprim 1.6～3kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, propylene glycol 40kg, 95% ethanol 10kg, surplus is a water for injection.
The best group of every 100L injection becomes: sulfadimidine sodium 10kg, and lincomycin hydrochloride 5kg, aminophenazone 10kg, trimethoprim 2kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, propylene glycol 40kg, 95% ethanol 10kg, surplus is a water for injection.
The present invention has following technique effect:
Injection of the present invention is the compound preparation that sulfadimidine sodium and lincomycin hydrochloride are united use, adopt double effects, dual pressing down killed pathogenic microorganism, reduce pathogenic microorganism and produce chemical sproof probability, and the sensitivity of increase pathogenic microorganism, and cooperate the agent of sulfanilamide special synergistic, and antibiosis is have a trimethoprim of potentiation, the effect of resisting pathogenic microbes is strengthened greatly, cooperate the antipyretic and anti-inflammatory aminophenazone, can bring down a fever fast, several drugs is by the rational proportion to each amounts of components, fast to responding well to treatment of the toxoplasmosis of pig, treating both the principal and secondary aspects of a disease has reduced medication number of times and dosage, and can effectively treat and pre-bacteriological protection secondary infection, reduce the drug resistance of pathogenic microorganism, make pig recover to accelerate.Simultaneously, compound preparation of the present invention is injection, and is easy to use, and a drug just can reach the therapeutic effect of multiple medications.
The preparation method technology of compound sodium sulfadimidine injection liquid for pig of the present invention is simple, realizes easily.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
Embodiment 1
(1) gets water for injection 30L, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg, after the stirring and dissolving, add sulfadimidine sodium 5kg again, be stirred to whole dissolvings.
(2) get propylene glycol 40kg, be heated to about 80 ℃ dissolving trimethoprim 1kg, lincomycin hydrochloride 10kg, aminophenazone 20kg, all dissolve about postcooling to 50 ℃.
(3) combining step (1) and the prepared solution of step (2), add 95% ethanol 10kg, add water for injection again to 100L, stir, keep 15-20min, with mass percent concentration is that 40% sodium hydroxide solution or concentration of volume percent are that 10% hydrochloric acid solution is regulated pH value to 10.22, treats that medicinal liquid promptly makes compound sodium sulfadimidine injection liquid for pig of the present invention after clear and bright.
Embodiment 2
(1) get water for injection 30L, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg, after the stirring and dissolving, sulfadimidine sodium 20kg is stirred to whole dissolvings again.
(2) get propylene glycol 40kg, be heated to about 80 ℃ dissolving trimethoprim 4kg, lincomycin hydrochloride 1kg, aminophenazone 5kg, all dissolve about postcooling to 50 ℃.
(3) combining step (1) and the prepared solution of step (2), add 95% ethanol 10kg, add water for injection again to 100L, stir, keep 15-20min, with mass percent concentration is that 40% sodium hydroxide solution or concentration of volume percent are that 10% hydrochloric acid solution is regulated pH value to 10.55, treats that medicinal liquid promptly makes compound sodium sulfadimidine injection liquid for pig of the present invention after clear and bright.
Embodiment 3
(1) get water for injection 30L, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg, after the stirring and dissolving, sulfadimidine sodium 8kg is stirred to whole dissolvings again.
(2) get propylene glycol 40kg, be heated to about 80 ℃ dissolving trimethoprim 1.6kg, lincomycin hydrochloride 7kg, aminophenazone 15kg, all dissolve about postcooling to 50 ℃.
(3) combining step (1) and the prepared solution of step (2), add 95% ethanol 10kg, add water for injection again to 100L, stir, keep 15-20min, regulate pH value to 10.65 with the hydrochloric acid solution of mass percent concentration 40% sodium hydroxide solution or concentration of volume percent 10%, treat that medicinal liquid promptly makes compound sodium sulfadimidine injection liquid for pig of the present invention after clear and bright.
Embodiment 4
(1) get water for injection 30L, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg, after the stirring and dissolving, sulfadimidine sodium 15kg is stirred to whole dissolvings again.
(2) get propylene glycol 40kg, be heated to about 80 ℃ dissolving trimethoprim 3kg, lincomycin hydrochloride 3kg, aminophenazone 8kg, all dissolve about postcooling to 50 ℃.
(3) combining step (1) and the prepared solution of step (2), add 95% ethanol 10kg, add water for injection again to 100L, stir, keep 15-20min, with mass percent concentration is that 40% sodium hydroxide solution or concentration of volume percent are that 10% hydrochloric acid solution is regulated pH value to 10.00～11.00, treats that medicinal liquid promptly makes compound sodium sulfadimidine injection liquid for pig of the present invention after clear and bright.
Embodiment 5
(1) get water for injection 30L, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg, after the stirring and dissolving, sulfadimidine sodium 12kg is stirred to whole dissolvings again.
(2) get propylene glycol 40kg, be heated to about 80 ℃ dissolving trimethoprim 2.4kg, lincomycin hydrochloride 4kg, aminophenazone 9kg, all dissolve about postcooling to 50 ℃.
(3) combining step (1) and the prepared solution of step (2), add 95% ethanol 10kg, add water for injection again to 100L, stir, keep 15-20min, with mass percent concentration is that 40% sodium hydroxide solution or concentration of volume percent are that 10% hydrochloric acid solution is regulated pH value to 10.35, treats that medicinal liquid promptly makes compound sodium sulfadimidine injection liquid for pig of the present invention after clear and bright.
Embodiment 6
(1) get water for injection 30L, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg, after the stirring and dissolving, sulfadimidine sodium 10kg is stirred to whole dissolvings again.
(2) get propylene glycol 40kg, be heated to about 80 ℃ dissolving trimethoprim 2kg, lincomycin hydrochloride 5kg, aminophenazone 10kg, all dissolve about postcooling to 50 ℃.
(3) combining step (1) and the prepared solution of step (2), add 95% ethanol 10kg, add water for injection again to 100L, stir, keep 15-20min, regulate pH value to 10.75 with the hydrochloric acid solution of mass percent concentration 40% sodium hydroxide solution or concentration of volume percent 10%, treat that medicinal liquid promptly makes compound sodium sulfadimidine injection liquid for pig of the present invention after clear and bright.
Clinical experiment:
1. laboratory animal:
100 of the ill pigs of picked at random.
2. experiment medicine
The compound sodium sulfadimidine injection liquid for pig our unit development of the embodiment of the invention 6 preparations;
10% sodium sulfadimidine injection liquid our unit prepared in laboratory;
5% lincomycin hydrochloride injection our unit prepared in laboratory.
3 experimental techniques:
The A group does not give Drug therapy for the blank group.
The B group is treated usage with 10% sodium sulfadimidine injection liquid: intramuscular injection, every 1kg body weight 0.15ml, 2 times on the one, logotype 3 days.
The C group is treated usage with 5% lincomycin hydrochloride injection: every 1kg body weight 0.15ml, 2 times on the one, logotype 3 days.
The D group is treated usage with the porcine compound sulfadiazine sodium injection of the embodiment of the invention 6 preparations: intramuscular injection, every 1kg body weight 0.15ml, 1 time on the one, logotype 3 times.
After the treatment beginning, every day, the distribution of pig health situation of change suffered from record, and treat and add up therapeutic effect after 7 days, wherein:
Invalid: as after referring to 7 days, to suffer from the pig symptom and do not have obvious change, still keep the preceding symptom of treatment.
Effectively: after referring to 7 days, suffer from the pig symptom and change, the effect before symptom is better than treating.
Cure: after referring to 7 days, transference cure is suffered from pig and is got well.Its numeral is included in the significant digits.
Symptom is arranged during end: after referring to 7 days, suffer from pig and still have certain symptom, its symptom performance is better than before the treatment or does not have change, suffers from pig and does not cure.Its numeral has been included in the numeral of invalid number and effective number.
Experimental result is as shown in table 1.
4. conclusion:
Analyze by statistics from the experimental result of table 1, compound sodium sulfadimidine injection liquid for pig treatment group, 10% sodium sulfadimidine injection liquid treatment group and the 5% lincomycin hydrochloride injection group of the embodiment of the invention 6 preparations and matched group difference is (P＜0.01) extremely significantly.Curative effect of the present invention is better than existing two kinds of medicines.
Table 1
| Numbering | Group | Invalid number | Effective number | Cure a number | Symptom pig's head number is arranged during end | A dead number |
| ??A | Matched group | ??25 | ??0 | ??0 | ??5 | ??20 |
| ??B | The treatment of 10% sodium sulfadimidine injection liquid | ??10 | ??15 | ??8 | ??10 | ??7 |
| ??C | The treatment of 5% lincomycin hydrochloride injection | ??13 | ??12 | ??5 | ??12 | ??8 |
| ??D | The compound sodium sulfadimidine injection liquid treatment of the embodiment of the invention 6 | ??2 | ??23 | ??21 | ??2 | ??2 |
Claims (6)
1. compound sodium sulfadimidine injection liquid for pig, it is characterized in that, consisting of of every 100L injection: sulfadimidine sodium 5～20kg, lincomycin hydrochloride 1～10kg, aminophenazone 5～20kg, trimethoprim 1～4kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, propylene glycol 40kg, 95% ethanol 10kg, surplus is a water for injection.
2. compound sodium sulfadimidine injection liquid for pig according to claim 1, it is characterized in that, consisting of of every 100L injection: sulfadimidine sodium 8～15kg, lincomycin hydrochloride 3～7kg, aminophenazone 8～15kg, trimethoprim 1.6～3kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, propylene glycol 40kg, 95% ethanol 10kg, surplus is a water for injection.
3. compound sodium sulfadimidine injection liquid for pig according to claim 1, it is characterized in that, consisting of of every 100L injection: sulfadimidine sodium 10kg, lincomycin hydrochloride 5kg, aminophenazone 10kg, trimethoprim 2kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, propylene glycol 40kg, 95% ethanol 10kg, surplus is a water for injection.
4. the preparation method of the described porcine compound sulfadimidine sodium injection of claim 1 is characterized in that, comprises the steps:
(1) gets water for injection 30L, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg, after the stirring and dissolving, add sulfadimidine sodium 5～20kg again, be stirred to whole dissolvings;
(2) get propylene glycol 40kg, be heated to 80 ℃ of dissolving trimethoprim 1～4kg, lincomycin hydrochloride 1～10kg, aminophenazone 5～20kg, all dissolve postcooling to 50 ℃;
(3) combining step (1) and the prepared solution of step (2), add 95% ethanol 10kg, add water for injection again to 100L, stir, keep 15-20min, with mass percent concentration is that 40% sodium hydroxide solution or concentration of volume percent are that 10% hydrochloric acid solution is regulated pH value to 10.00～11.00, treats that medicinal liquid promptly makes compound sodium sulfadimidine injection liquid for pig of the present invention after clear and bright.
5. the preparation method of porcine compound sulfadimidine sodium according to claim 4, it is characterized in that, sulfadimidine sodium 8～15kg in every 100L injection, lincomycin hydrochloride 3～7kg, aminophenazone 8～15kg, trimethoprim 1.6～3kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, propylene glycol 40kg, 95% ethanol 10kg, surplus is a water for injection.
6. the preparation method of porcine compound sulfadimidine sodium according to claim 4, it is characterized in that, sulfadimidine sodium 10kg in every 100L injection, lincomycin hydrochloride 5kg, aminophenazone 10kg, trimethoprim 2kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, propylene glycol 40kg, 95% ethanol 10kg, surplus is a water for injection.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2009103047386A CN101606945A (en) | 2009-07-23 | 2009-07-23 | Compound sodium sulfadimidine injection liquid for pig and preparation method thereof |
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| CNA2009103047386A CN101606945A (en) | 2009-07-23 | 2009-07-23 | Compound sodium sulfadimidine injection liquid for pig and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101954084A (en) * | 2010-09-06 | 2011-01-26 | 北京大北农动物保健科技有限责任公司 | Medicinal composition for treating mixed infection in livestock and poultry and preparation method thereof |
| CN102091029A (en) * | 2010-12-10 | 2011-06-15 | 上海恒丰强动物药业有限公司 | Sulfadimidine solution and preparation method thereof |
| CN103494834A (en) * | 2013-10-12 | 2014-01-08 | 成都乾坤动物药业有限公司 | Anti-infectious veterinary pharmaceutical composition and preparation method and application thereof |
| CN103709109A (en) * | 2013-12-24 | 2014-04-09 | 福建省福抗药业股份有限公司 | Preparation method of sulfadimidine hydrosulfate |
| EP3049123A4 (en) * | 2013-09-26 | 2017-06-21 | Krzysztof Appelt | Catheter locking formulation and method to prepare same |
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2009
- 2009-07-23 CN CNA2009103047386A patent/CN101606945A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101954084A (en) * | 2010-09-06 | 2011-01-26 | 北京大北农动物保健科技有限责任公司 | Medicinal composition for treating mixed infection in livestock and poultry and preparation method thereof |
| CN101954084B (en) * | 2010-09-06 | 2015-06-17 | 北京大北农动物保健科技有限责任公司 | Medicinal composition for treating mixed infection in livestock and poultry and preparation method thereof |
| CN102091029A (en) * | 2010-12-10 | 2011-06-15 | 上海恒丰强动物药业有限公司 | Sulfadimidine solution and preparation method thereof |
| EP3049123A4 (en) * | 2013-09-26 | 2017-06-21 | Krzysztof Appelt | Catheter locking formulation and method to prepare same |
| US10335518B2 (en) | 2013-09-26 | 2019-07-02 | Krzysztof Appelt | Catheter locking formulation and method to prepare same |
| CN103494834A (en) * | 2013-10-12 | 2014-01-08 | 成都乾坤动物药业有限公司 | Anti-infectious veterinary pharmaceutical composition and preparation method and application thereof |
| CN103709109A (en) * | 2013-12-24 | 2014-04-09 | 福建省福抗药业股份有限公司 | Preparation method of sulfadimidine hydrosulfate |
| CN103709109B (en) * | 2013-12-24 | 2016-08-17 | 福建省福抗药业股份有限公司 | A kind of preparation method of sulfadimidine hydrosulfate |
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Application publication date: 20091223 |